KR20090097973A - Hair loss prevention caffeine acetate sodium hyaluronate mixture and cosmetic composition for preventing hair loss comprising the mixture - Google Patents
Hair loss prevention caffeine acetate sodium hyaluronate mixture and cosmetic composition for preventing hair loss comprising the mixture Download PDFInfo
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- KR20090097973A KR20090097973A KR1020080023075A KR20080023075A KR20090097973A KR 20090097973 A KR20090097973 A KR 20090097973A KR 1020080023075 A KR1020080023075 A KR 1020080023075A KR 20080023075 A KR20080023075 A KR 20080023075A KR 20090097973 A KR20090097973 A KR 20090097973A
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- hair loss
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- 239000000203 mixture Substances 0.000 title claims abstract description 18
- 239000002537 cosmetic Substances 0.000 title claims abstract description 13
- 229920002385 Sodium hyaluronate Polymers 0.000 title claims abstract description 9
- 229940010747 sodium hyaluronate Drugs 0.000 title claims abstract description 9
- 230000003658 preventing hair loss Effects 0.000 title abstract description 10
- WXGTYYQGZXNKBV-UHFFFAOYSA-M sodium 1,3,7-trimethylpurine-2,6-dione acetate Chemical compound C(C)(=O)[O-].[Na+].N1(C)C(=O)N(C)C=2N=CN(C)C2C1=O WXGTYYQGZXNKBV-UHFFFAOYSA-M 0.000 title 1
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims abstract description 56
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 39
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229960001948 caffeine Drugs 0.000 claims abstract description 28
- 230000000694 effects Effects 0.000 claims abstract description 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 7
- 229960000583 acetic acid Drugs 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- -1 hair rinse Substances 0.000 claims description 3
- 239000002453 shampoo Substances 0.000 claims description 3
- 239000000443 aerosol Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000008266 hair spray Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001256 tonic effect Effects 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 abstract description 17
- 230000003676 hair loss Effects 0.000 abstract description 16
- 208000024963 hair loss Diseases 0.000 abstract description 16
- 210000003780 hair follicle Anatomy 0.000 abstract description 14
- 210000004761 scalp Anatomy 0.000 abstract description 14
- 229940088597 hormone Drugs 0.000 abstract description 8
- 239000005556 hormone Substances 0.000 abstract description 8
- 210000003491 skin Anatomy 0.000 abstract description 5
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 230000003656 anti-hair-loss Effects 0.000 abstract description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 10
- 229960003604 testosterone Drugs 0.000 description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000003779 hair growth Effects 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000000052 vinegar Substances 0.000 description 3
- 235000021419 vinegar Nutrition 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 230000009583 hair follicle growth Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000016507 interphase Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 235000003368 Ilex paraguariensis Nutrition 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 241000533293 Sesbania emerus Species 0.000 description 1
- AMMHDXLWLCQPML-UHFFFAOYSA-N [Na].N1(C)C(=O)N(C)C=2N=CN(C)C2C1=O Chemical group [Na].N1(C)C(=O)N(C)C=2N=CN(C)C2C1=O AMMHDXLWLCQPML-UHFFFAOYSA-N 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- RSIHSRDYCUFFLA-DYKIIFRCSA-N boldenone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 RSIHSRDYCUFFLA-DYKIIFRCSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- RSIHSRDYCUFFLA-UHFFFAOYSA-N dehydrotestosterone Natural products O=C1C=CC2(C)C3CCC(C)(C(CC4)O)C4C3CCC2=C1 RSIHSRDYCUFFLA-UHFFFAOYSA-N 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 210000000442 hair follicle cell Anatomy 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000020331 mate tea Nutrition 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 남성호르몬으로 인한 탈모에 억제 작용을 지닌 카페인을 아세트 산을 이용하여 두피로 침투시키고 히알우론산나트륨을 이용하여 카페인이 두피에 지속적으로 잔류하여 모낭에 직접적으로 탈모방지 작용을 하도록 고안된 탈모방지용 화장료 조성물에 관한 것으로, 본 발명에 의하면 카페인, 히알우론산나트륨, 아세트산 혼합물이 피부의 남성호르몬의 영향을 저해하여 인체의 어떠한 부작용도 일으키지 않으면서도 우수한 탈모방지 효과를 발휘한다.The present invention is a cosmetic for preventing hair loss designed to prevent caffeine having an inhibitory effect on hair loss due to male hormones into the scalp using acetic acid, and caffeine continuously in the scalp using sodium hyaluronate to directly prevent hair loss on hair follicles. The present invention relates to a composition, and according to the present invention, caffeine, sodium hyaluronate, and acetic acid mixture exhibit an excellent anti-hair loss effect without inhibiting the effects of male hormones on the skin without causing any side effects of the human body.
Description
본 발명은 남성호르몬으로 인한 탈모에 억제활성작용을 가지고 있는 카페인을 히알우론산나트륨과 혼합하여 피부의 습기를 유지하고 이에 피부침투력이 강력한 아세트산을 포함하는 탈모방지용 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition for preventing hair loss comprising acetic acid having a suppressive activity against male hair loss caused by male hormone and mixed with sodium hyaluronate to maintain the moisture of the skin and strong skin penetration.
탈모는 현대 사회의 각종 스트레스 및 환경오염, 각종 화장품 및 세발제의 사용과 유전적 요인 등으로 인해 나타나며, 발모 또는 육모에 대한 관심이 증가되고 있으나 의학적 지식 및 생리적 작용에 대해서는 아직 뚜렷한 성과를 보이지 않고 있으나 현재까지 밝혀진 탈모의 생리학적 원인은 남성 호르몬이 모낭 세포의 대사에 관여하면서 탈모증이 발생하는 것으로 알려져 있다. 호르몬에 의한 원인으로 해당 두피 모낭이 다른 쪽 모낭에 비해 더 빨리 휴지기에 들어가게 되고 이에 따라 휴지기의 모낭의 비율이 증가하고 성장기 모낭은 점차 줄어 탈모가 되는 것이다.Hair loss is caused by stress and environmental pollution in the modern society, the use of various cosmetics and hairdressing agents, and genetic factors.Increasing interest in hair growth or hair growth is not yet apparent in medical knowledge and physiological effects. However, the physiological cause of hair loss that has been discovered so far is known that alopecia occurs when testosterone is involved in the metabolism of hair follicle cells. Hormonal causes the scalp hair follicles to enter the resting phase faster than the other hair follicles, thereby increasing the proportion of hair follicles in the resting phase and hair follicles in the growing phase gradually decreases.
종래에는 이러한 탈모의 원인을 제거하기 보다 발모를 촉진하기 위한 약물이 사용되었다. 이러한 약물은 미합중국특허 제4, 596, 812호인 업존사(Hpjohn Co.Ltd)의 미녹시딜(Minoxidile)이 있다.Conventionally, drugs for promoting hair growth have been used rather than eliminating the cause of such hair loss. Such drugs include Minoxidil from Hpjohn Co. Ltd., US Pat. No. 4,596,812.
본 발명자는 탈모증상을 방지하기 위한 약물을 조사하던 중 카페인이 남성호르몬으로 인한 탈모를 방지한다는 연구사실(International Journal of Dermatology Volume 46 Issue 1 Page 27-35, January 2007 : T. W. Fischer MD, U. C. Hipler PhD, P. Elsner MD (2007) Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro )을 근거로 모낭에 직접적으로 카페인이 오랫동안 국소작용을 할 수 있는 화장료 조성을 발명하게 된 것이다.The inventors of the present invention found that caffeine prevents hair loss due to male hormones while investigating drugs to prevent hair loss. (International Journal of Dermatology Volume 46 Issue 1 , P. Elsner MD (2007) Effect of caffeine and testosterone on the proliferation of human hair follicles in Based on the in vitro ), caffeine directly in the hair follicles has been invented a cosmetic composition that can be localized for a long time.
카페인의 탈모방지 효과는 남성호르몬인 테스토스테론에 의한 피부의 수분 상실을 막아주며 디하이드로 테스토스테론에 의한 모낭을 수축 현상을 막아주는 것으로 나타났으며 탈모방지 효과를 나타내기 위한 카페인의 농도는 0.001%에서 0.005%에서 연구되었다.Caffeine prevents hair loss due to testosterone, a male hormone, and prevents hair follicle shrinkage caused by dehydrotestosterone. The caffeine concentration is 0.001% to 0.005 to prevent hair loss. Was studied in%.
이를 응용한 제품으로 카페인이 함유된 샴푸가 개발되어 있으나 카페인이 함유된 샴푸가 두피에 작용하는 시간이 짧다는 점이 단점이다.Although a shampoo containing caffeine has been developed as a product applying this, the disadvantage is that the shampoo containing caffeine acts on the scalp for a short time.
본 발명은 탈모의 원인인 모낭의 남성호르몬의 영향을 저해하는 카페인을 모낭에 직접적으로 오랫동안 작용하여 탈모를 방지하기 위한 카페인 및 이를 포함한 탈모방지용 화장료 조성물을 제공하는 것을 목적으로 한다.It is an object of the present invention to provide a caffeine for inhibiting the effects of male hormones of hair follicles, which causes hair loss, by directly acting on hair follicles for a long time to prevent hair loss and a cosmetic composition for preventing hair loss.
상기의 목적을 달성하기 위한 본 발명은 물, 히알우론산나트륨, 아세트산, 콜라겐 또는 이들 중 2 이상의 혼합물을 포함하여 이루어지는 그룹과 남성호르몬으로 인한 탈모를 방지하는 작용을 지는 카페인을 제공한다.The present invention for achieving the above object provides a group comprising a water, sodium hyaluronate, acetic acid, collagen or a mixture of two or more thereof and caffeine having the action of preventing hair loss due to male hormones.
또한 본 발명은 상기 탈모방지용 카페인을 포함하여 이루어짐을 특징으로 하는 탈모방지용 화장료 조성물을 제공한다.In another aspect, the present invention provides a cosmetic composition for preventing hair loss comprising the caffeine for preventing hair loss.
또한 본 발명은 상기 탈모방지용 화장료 조성물을 이용한 화장품을 제공한다.In another aspect, the present invention provides a cosmetic using the cosmetic composition for preventing hair loss.
이하, 본 발명을 보다 상세하게 설명하기로 한다.Hereinafter, the present invention will be described in more detail.
본 발명에서 탈모방지용 카페인은 화학식 C8H10O2N4. 3개의 메틸기를 가진 크산틴 구조로서 브라질의 커피콩에 1∼1.5%, 동양의 차 잎에 1~5%, 열대 아프리카의 콜라 열매에 3%, 파라과이의 마테차에 1∼2%, 브라질의 구아라나 종자에 3∼5% 존재하는 흥분성 성분으로 백색의 연한 결정이다. 찬물에는 녹기 어렵고 뜨거운 물에는 잘 녹으며 쓴맛이 있다. 녹차 등에서 뜨거운 물로 삼출시켜 타닌 등을 제거하고 단리(單離)할 수 있다. 또 디메틸요소·말론산을 출발물질로 하여 화학적으로 합성할 수도 있다. 식물 속에서의 합성은 그 밖의 퓨린염기와 마찬가지로 글리신·포름산·이산화탄소 등을 재료로 하여 합성된다. 또 3개가 존재하는 메틸기는 메티오닌에서 유래하고 있다. Caffeine for preventing hair loss in the present invention is represented by the formula C 8 H 10 O 2 N 4 . Xantine structure with three methyl groups: 1-1.5% in Brazilian coffee beans, 1-5% in oriental tea leaves, 3% in Cola fruits in tropical Africa, 1-2% in Mate tea in Paraguay, guar in Brazil Excitant component present in 3 to 5% of lana seeds. It is a white, light crystal. It is difficult to dissolve in cold water, melts well in hot water and has a bitter taste. Hot water can be exuded from green tea and the like to remove and isolate tannins. It is also possible to chemically synthesize dimethylurea-malonic acid as a starting material. Synthesis in plants is synthesized using glycine, formic acid, carbon dioxide and the like as other purine bases. In addition, three methyl groups exist from methionine.
T. W. Fischer등에 의해 연구된 바에 의하며 카페인의 탈모방지효과 연구결과는 다 음과 같다. 남성호르몬에 의한 탈모현상을 일으키는 두피의 모낭을 절취하여 시험관에서 120-192시간 배양을 할 때 실험물질을 넣지 않은 대조군과 카페인, 남성호르몬의 농도를 달리하여 주입한 실험군을 비교해 본 결과 5μg/mL의 테스토스테론을 주입한 군에서 모낭의 성장이 저해됨이 관찰되었고, 5μg/mL의 테스토스테론이 주입된 군에 0.001%와 0.005%의 카페인이 주입된 실험군에서 모낭의 성장이 활성화 됨이 관찰되었다. 또한 카페인을 단독으로 주입한 결과 모낭성장이 촉진되었다. Based on the research by T. W. Fischer et al., The results of caffeine anti-hair loss are as follows. When the hair follicles of the scalp causing male hair loss were removed and cultured in vitro for 120-192 hours, the control group containing no test substance and the experimental group injected with different concentrations of caffeine and male hormone were 5μg / mL. Inhibition of hair follicle growth was observed in the testosterone-injected group, and the growth of hair follicles was activated in the experimental group in which 0.001% and 0.005% caffeine were injected in the 5μg / mL testosterone-injected group. In addition, the injection of caffeine alone promoted hair follicle growth.
카페인이 남성형 탈모방지에 효과적임이 증명되었으나 카페인은 수용성인 관계로 두피를 통과하여 모낭까지 적절하게 전달되도록 하는 것이 중요하다. Although caffeine has been shown to be effective in preventing male-type hair loss, it is important that caffeine be soluble in the hair follicles through the scalp.
카페인이 두피를 침투하여 두피에 오랫동안 머무르기 위해서는 카페인을 효과적으로 두피에 침투하도록 하고, 두피에 오랫동안 잔류하게 하는 전달물질이 필요하며, 두피 침투를 위한 아세트산과 수분과 카페인을 오랫동안 잔류게 하는 히알우론산나트륨을 조합하여 카페인을 효과적으로 전달할 수 있는 물질조성을 발명하였다.In order for caffeine to penetrate the scalp and stay on the scalp for a long time, a caffeine is required to effectively penetrate the scalp, and a long-lasting substance on the scalp. By inventing a material composition that can effectively deliver caffeine.
아세트산은 식초등에 포함된 화학식은CH3COOH이다. 식초에서 나는 신맛이 아세트산에 의한 것으로, 식초에는 아세트산이 약 4%가량 포함되어 있다. 식초의 원료로 쓰이고 있어 아세트산을 초산이라고 부르기도 한다. 이러한 아세트산은 친지성과 친수성을 동시에 지니고 있어 생체 조직내 약물 전달 물질로 사용되고 있으며 두피에 수용성인 카페인과 히알우론산의 두피 내 침투를 용이하게 한다.Acetic acid is a chemical formula contained in vinegar, etc. is CH 3 COOH. The sour taste of vinegar is caused by acetic acid, which contains about 4% of acetic acid. Since it is used as a raw material of vinegar, acetic acid is also called acetic acid. Since acetic acid has both lipophilic and hydrophilic properties, it is used as a drug delivery material in biological tissues and facilitates the penetration of caffeine and hyaluronic acid that are soluble in the scalp into the scalp.
히알우론산나트륨은 천연화합물로서 생체의 피부 및 세포조직에 많이 분포되어 있으며 보습효과가 뛰어난 것으로 알려져 있어 화장품의 조성물질로 많이 사용되고 있다. 이러한 히알우론산의 특징을 이용하여 두피의 보습작용 및 수용성인 카페인이 히알우론산에서 서서히 방출되도록 혼합하여 오랫동안 카페인이 피부조직에 머무르며 두피의 모낭에 작용할 수 있다.Sodium hyaluronate is a natural compound that is widely distributed in the skin and tissues of the living body and is known to be excellent in moisturizing effects, and is widely used as a composition of cosmetics. By using the features of hyaluronic acid, the moisturizing action of the scalp and the water-soluble caffeine is mixed so as to be released slowly from the hyaluronic acid, caffeine can stay in the skin tissue for a long time and act on the hair follicles of the scalp.
탈모방지를 위한 카페인 히알우론산나트륨 아세트산 혼합물의 조성은 다음과 같이 실시할 수 있으며 물과 혼합하여 다음 예의 농도로 만든 후 이를 두피에 직접 하루 2~3회 탈모부위에 도포한다. The composition of the caffeine sodium hyaluronate acetic acid mixture to prevent hair loss can be carried out as follows, and mixed with water to make the concentration of the following example and apply it directly to the hair loss site 2-3 times a day.
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| KR20220124815A (en) * | 2020-02-25 | 2022-09-14 | 앰플리피카 인코포레이티드 | Composition and method for promoting hair growth |
| US20220331223A1 (en) * | 2021-04-14 | 2022-10-20 | Virtue Labs, LLC | Hair treatment compositions and methods of use |
| US11883519B2 (en) | 2017-06-26 | 2024-01-30 | Virtue Labs, LLC | Cosmetic compositions and methods of use |
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| US11883519B2 (en) | 2017-06-26 | 2024-01-30 | Virtue Labs, LLC | Cosmetic compositions and methods of use |
| US12208153B2 (en) | 2017-06-26 | 2025-01-28 | Virtue Labs, LLC | Cosmetic compositions and methods of use |
| KR20220124815A (en) * | 2020-02-25 | 2022-09-14 | 앰플리피카 인코포레이티드 | Composition and method for promoting hair growth |
| US20220331223A1 (en) * | 2021-04-14 | 2022-10-20 | Virtue Labs, LLC | Hair treatment compositions and methods of use |
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