KR20090091898A - Oral compositions containing luffa cylindrica - Google Patents

Abstract

The present invention relates to a composition for oral cavity containing slices or extracts of scrubber cucumber, or both, thereby smoothing blood flow in the gums and preventing and alleviating oral inflammation by anti-inflammatory and antibacterial activity.

Description

Oral compositions containing Loofah Cucumber {Oral compositions containing Luffa cylindrica}

The present invention relates to compositions for oral cavity containing fragments or extracts of scrubber cucumber, or both.

Lumpa cylindrical is a vine-like plant of annual fruit, also known as loofah, apple, hydrangea, aquatic plant, gulf, cheonraksa (天 絡 絲) or cheonra (天 羅). The stalk splits and lifts up with tendrils to wind up other objects. Leaves are palm-shaped, similar to cucumber leaves, and flowers run from July to October. A male flower blooms in front of each armpit, and a female flower blooms in leaf axle. Fruits ripen in October, about 30㎝ ~ 70㎝ long, like green cucumbers, and then green when ripe.

Young fruits are used for food, and mature fibers are mainly used to make axles for axles of railroad cars, to wash ships and decks, to rug bottoms, to cover women's hats, slippers and baskets. The name of the fruit comes from the use of this fibrous tissue as a loofah.

The scrubber ingredient so far discovered contains nutrients that supply various cells to control osmotic pressure, carotene that lowers heat and detoxification, and protein that also plays a role in immune and blood production and blood circulation. In addition, it contains various ingredients such as dietary fiber, calcium, potassium, iron, magnesium, and essential amino acids.

Scrub cucumbers are so tender that they cut off phlegm that causes a lot of heat in your body. By cooling hot blood, it promotes blood circulation, anti-inflammatory, and helps to treat constipation and sinusitis. In addition, scrubber seeds and leaves have a diuretic and detoxification effect, the skin and roots are known to have analgesic anti-inflammatory action. The sap coming from the cut surface of the stem of the loofah is edible and also used as a raw material for cosmetics.

Meanwhile, aminocaproic acid, vitamin E acetate (tocopherol acetate), allantoin and its derivatives, tranexamic acid, salt, pyridoxine (vitamin B6), and the like have been used for preventing or alleviating gum inflammation in existing oral compositions. In addition, Sanguinaria extract (US Pat. No. 4,689,216), Myrrh, Rhatany, Sage (Sage), which has been widely used in the private sector for thousands of years and is known to be effective in causing diseases of oral diseases. ), Extracts of chamomile, Echinacea (S.deRysky; Journal of Clinical Dentistry Vol.I, Supplement A. A22-24,1988), Sage and Rosemary Extracts of medicinal plants such as extracts (Japanese Patent Laid-Open No. 58-134013) and Hops extract (Japanese Patent Laid-Open No. 62-138420) were used for preventing or alleviating gum inflammation. However, as these materials, it was difficult to sufficiently achieve the effect of preventing or alleviating gum inflammation, and in some cases, an amount sufficient to exhibit efficacy by causing a change in the stability of the toothpaste in the toothpaste formulation in the formulation of the oral composition was applied. There was something difficult to do.

Accordingly, the present inventors studied a material that has an excellent effect on relieving oral inflammation and promotes blood flow in the gums and shows an excellent effect on the prevention of oral inflammation. Thus, slices or extracts of scrubbers in oral products including toothpaste have been studied. Although no direct or all of these have been applied directly, the fragments and / or extracts of these scrubbers have been found to have the same effect and have completed the present invention.

One object of the present invention is to provide a composition for oral cavity containing fragments or extracts of scrubber cucumber, or both.

Another object of the present invention as a formulation comprising the composition for oral cavity, to provide a toothpaste, mouthwash and mouthwash.

In one embodiment, the present invention relates to a composition for oral cavity containing fragments or extracts of scrubber cucumber, or both.

The loofah cucumber of the present invention is a vine-like plant of annual fruit, and refers to a plant also known as loofah, apple, hydrangea, achene, gulf, cheonraksa, cheonra or loofah. Sections and extracts of the scrubber cucumber of the present invention are derived from all parts of the root, stem, leaves, shells, fibers and the like of the scrubber cucumber, and are not limited to a part of the scrubber cucumber.

The slice of the scrubber cucumber of the present invention is a finely crushed scrubber cucumber 1 to 6 mm in size refers to a larger size than the powder form. When the slices of the scrubber cucumber is smaller than 1 mm, physical gum massage effects cannot be expected, and when the slices of the scrubber cucumber are larger than 6 mm, there is a problem in that the number of the pieces to be mixed is less than that of the scrubber cucumber. The slices of the scrubber cucumber are contained in an amount of 0.05 to 10% by weight, preferably 0.1 to 6% by weight, more preferably 0.5 to 5% by weight, based on the total weight of the composition for oral cavity of the present invention. When the content of the slices of the scrubber cucumber is less than 0.05% by weight, the effect is weak, if higher than 10% by weight, the composition and the stability of the composition is not good, there is a problem that the cost is too high compared to the increase in effect.

The extract of scrubber cucumber of the present invention can be prepared by a method for preparing an extract known in the art. That is, the scouring pad is dried and rinsed, and then extracted with a solvent, preferably water, purified water or one or more solvents selected from the group consisting of lower alcohols, normal hexane and 1,3-butylene glycol. More specifically, after washing the scrubber with water or purified water according to a conventional method, the drying treatment such as lyophilization, natural drying or hot air drying is performed according to a conventional method. Subsequently, after washing the dried scrubber cucumber, 500 ml of a solvent mixed with at least one of water, purified water, lower alcohol (for example, ethanol, methanol, butanol, etc.), normal hexane, 1,3-butylene glycol, and the like 50 g of scrubbers were immersed and filtered for 3 days, and then concentrated under reduced pressure to prepare an extract of scrubber cucumber of the present invention.

The extract of the scrubber cucumber is contained 0.01 to 2% by weight, preferably 0.05 to 2% by weight in the total weight of the composition for oral cavity of the present invention. At a concentration of less than 0.01% by weight of the extract content of the scrubber cucumber can not expect efficacy and effects on gingival inflammation, when exceeding 2.0% by weight is unsuitable for the stability of the product.

The composition for oral cavity of the present invention may contain each of the slices of the loofah cucumber or the extract of the loofah cucumber, or may contain both the slices of the loofah and cucumber extract. Preferably, the composition for oral cavity of the present invention contains both a slice of scrubber and an extract of scrubber. When both the fragment of the loofah cucumber and the extract of the loofah cucumber are contained in the composition for oral cavity of the present invention in an appropriate ratio within each content of the fragment of the loofah cucumber or the extract of the loofah cucumber.

The composition for oral cavity according to the present invention is effective in smoothing the blood flow in the gum by the gum massage effect, and preventing and alleviating the inflammation of the gum by anti-inflammatory and antibacterial action. This effect can be seen through the clinical experiment of the effect test example of the present specification, which is a composition for the oral cavity of the present invention to smooth the blood flow by physical massage of the gums and gums due to anti-inflammatory and antibacterial effect by the antibacterial component in the scrubber component It means that inflammation can be prevented and alleviated.

The fragments of the scrubber cucumber and the extract of scrubber cucumber contained in the composition for oral cavity according to the present invention are derived from the edible scrubber cucumber and are therefore almost nontoxic. Therefore, the composition for oral cavity of this invention is harmless to a human body, and can be used safely.

The composition for oral cavity according to the present invention is not particularly limited in the formulation, and specific examples may include formulations such as toothpaste, mouthwash, mouthwash, gum, candy, oral spray, and mouthwash.

As an example, when the composition for oral cavity of the present invention is a toothpaste formulation, it may contain an abrasive, a humectant, a binder, a foaming agent, a sweetening agent, a pH adjusting agent, a preservative, an active ingredient, a fragrance, a brightener, a pigment, a solvent, and the like. . In addition, the toothpaste can be applied to the tube of the existing ointment (paste) in the form of formulation and packaging of the final product.

Examples of the abrasive include precipitated silica, silica gel, zirconium silicate, calcium dihydrogen phosphate, anhydrous calcium dihydrogen phosphate, hydrous alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate and aluminum silicate. . The abrasive component may be added alone or in combination of two or more thereof in an amount of 5 to 60 wt% based on the total weight of the composition. Although the particle size of an abrasive | polishing agent changes with kinds, it is preferable to use the thing whose average particle diameter is 20 micrometers or less.

The humectant is an essential ingredient in the preparation of the ointment formulation, it prevents dry solidification when the toothpaste is exposed to the air and gives a shine to the surface of the toothpaste, and also serves to sweeten the toothpaste depending on the type. Examples of the humectant include concentrated glycerin (98%), glycerin (85%), sorbitol aqueous solution (70%), amorphous sorbitol aqueous solution (70%), ziitol, polyethylene glycols and propylene glycol, and the like. May be added alone or in combination of two or more of 40 to 70% by weight based on the total weight of the composition.

The binder serves to prevent the solid powder and liquid components from being separated, and is essential in the ointment toothpaste. The binder can be used as long as it is a water-soluble polymer. Examples of commonly used components include sodium carboxymethyl cellulose derived from cellulose, carrageenan extracted from seaweed, and xanthan gum obtained from metabolism of microorganisms. The binder component alone or in combination of two or more thereof may be added in an amount of 0.1 to 5% by weight, preferably 0.1 to 2% by weight, based on the total weight of the composition.

The foaming agent acts to easily remove foreign substances in the oral cavity by enhancing the feeling of use of the product, aiding in the cleaning action, and speeding up the dispersion and penetration of other active ingredients and reducing the interfacial tension. As the foaming agent, sodium lauryl sulfate, an anionic surfactant, is mainly used.A copolymer of polyoxyethylene polyoxypropylene (polyoxamer), polyoxyethylene cured castor oil, poly Oxyethylene sorbitan fatty acid ester and the like can be used. The foaming agent component may be added at 0.1 to 2% by weight relative to the total weight of the composition.

As the sweetener, saccharin sodium, aspartame, stevioside, xylitol, and licorice may be used alone or in combination of two or more, and may be used in an amount of 0.05 to 5 wt% based on the total weight of the composition.

The pH adjusting agent includes sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, sodium citrate, citric acid, tartaric acid, and the like. The preservatives include methyl paraoxyanmic acid (methylparaben), propyl paraoxybenzoic acid, and benzoic acid. Sodium may be used alone or in combination of two or more thereof.

As the active ingredient, a fluoride which forms a fluorine film on the teeth to be strong against acid (lactic acid), which is a metabolite of cavities, and aminocapronic acid, allantoin and allantoin derivatives and vitamins for preventing periodontal disease can be used simultaneously. Triclosan or the like may be used alone or in combination of two or more for the purpose of inhibiting the growth of harmful microorganisms in the oral cavity to promote oral hygiene.

The fragrance may be mixed with a suitable amount of peppermint oil, spearmint oil, menthol, anetol and the like, titanium dioxide may be used as the brightener, food coloring, purified water, ethanol, etc. may be used as the pigment. Can be.

The above ingredients are used to prepare a conventional toothpaste manufacturing method.

As an example, when the composition for oral cavity of the present invention is a formulation of a mouthwash or mouthwash, the above-described abrasives, wetting agents, binders, sweeteners, pH adjusting agents, preservatives, active ingredients, fragrances, brighteners, pigments, solvents And the like. Using the above ingredients, it is prepared according to a conventional method for preparing a mouthwash or mouthwash.

The composition for oral cavity of the present invention has an effect of preventing and alleviating oral inflammation by anti-inflammatory and antimicrobial activity along with the gum massage effect, can greatly contribute to oral health hygiene through the prevention and treatment of oral diseases.

Hereinafter, the present invention will be described in more detail with reference to the following examples and comparative examples. However, these are only illustrations for aiding understanding of the present invention, and the scope of the present invention is not limited thereto.

Example  1 to 7 and Comparative example

Oral compositions according to the present invention (Examples 1 to 7) and conventional oral and in particular toothpaste compositions (comparative examples) were prepared for comparison with the composition ratios as shown in Table 1 below.

The specific manufacturing method thereof is as follows. After drying the scrubber bark, fibers, stems, leaves, roots and crushed to a size of about 1 ~ 6 mm to prepare a slice of the scrubber cucumber, the extract was further extracted with ethanol or purified water to prepare an extract of scrubber cucumber. .

Disperse the binder and other additives (fragrance, saccharin), etc. in the wetting agent, add an active ingredient such as an abrasive and stir for about 30 minutes, add a foaming agent, a scouring pad, and a perfume component, and then stir for 20 minutes under vacuum. A product was obtained.

division Name Example Comparative example One 2 3 4 5 6 7 abrasive Precipitated silica 20.0 20.0 20.0 20.0 20.0 20.0 20.0 20.0 Humectant Concentrated glycerin (98%) 40.0 - 20.0 - 25.0 - - - Sorbitol aqueous solution (70%) - 50.0 30.0 40.0 40.0 40.0 35.0 40.0 Zyritol 1.0 - - 1.0 - - - Foam Sodium Lauryl Sulfate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Poloxamer - - - 0.5 - - - - Binder Carboxymethyl Cellulose Sodium 0.2 0.4 - 0.2 - 0.8 - 0.2 Xanthan Gum 0.5 - 0.8 0.5 0.6 0.2 - 0.5 Carrageenan - 0.5 - 0.8 - 0.5 1.0 - Scrubber Extract Scrubber Extract - - 1.0 - - 0.1 1.5 - Scrubber cutting (mm) 1.0 x1.0 x1.0 0.3 3.0 - - - - - - 3.0 x3.0 x3.0 - - - - 2.0 - - - 6.0 x6.0 x6.0 - - 1.0 3.0 - - - - Fluoride Sodium fluoride 0.22 - - 0.22 - 0.22 0.22 0.22 Sodium Fluoride - 0.76 0.76 - 0.76 - - - additive Spices 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Saccharin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Purified water Up to 100% by weight Unit: weight%

Effect Test Example 1 : Evaluation of clinical oral inflammation relieving effect

In order to clinically confirm the oral inflammation relieving effect of the composition for oral cavity of Examples 1 to 7, 320 men and women 20 to 40 years old suffering from oral inflammation were selected and divided into eight groups. After the oral examination of marginal and papillary gingiva of upper and lower jaw according to Loe and Silness gingival score criteria, the test subjects were compared with the use groups of Examples 1 to 7 so that the test results were not different. Yes divided into groups. To provide the same toothbrush and brushed in the habitual method to record the score in the same manner as in Table 2 at the stage of 3 months to obtain the results shown in Table 3.

score Contents 0 points Normal gingiva 1 point Mild gingivitis (when the gingiva has a light color change) 2 points Moderate gingivitis (when bleeding due to gloss, redness, swelling, swelling or pressurization of the gingiva surface) 3 points High gingivitis (when the gingiva has significant redness and swelling, ulcers, and natural bleeding)

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative example Early 0.82 ± 0.53 0.86 ± 0.49 0.81 ± 0.51 0.81 ± 0.48 0.85 ± 0.39 0.84 ± 0.45 0.82 ± 0.55 0.84 ± 0.50 6 months 0.75 ± 0.38 0.61 ± 0.42 0.40 ± 0.49 0.47 ± 0.38 0.55 ± 0.51 0.55 ± 0.38 0.43 ± 0.47 0.83 ± 0.52 Significance 1 p <0.05 p <0.05 p <0.05 p <0.05 p <0.05 p <0.05 p <0.05 p ＞ 0.05 Significance 2 p <0.05 p <0.05 p <0.05 p <0.05 p <0.05 p <0.05 p <0.05 -

Significance 1: gingival t-valuation at the beginning of the trial and at 6 months

Significance 2: t-test with Comparative Example after 6 months

As shown in the results of Table 3, the gingival index of the group using the composition for oral cavity prepared in Examples 1 to 7 was statistically significantly reduced, and also statistically significant differences with the composition of the comparative example. From the above results, the composition for oral cavity according to the present invention was evaluated to be superior to the oral inflammation relieving effect compared to the conventional toothpaste.

Effect Test Example 2: Gum blood flow promotion effect of the gum massage

In order to evaluate the inflammatory relieving effect of the composition for oral cavity of the present invention, the blood flow promoting effect by the loofah massage of the loofah section was compared by measuring the change in the blood flow of the gum before and after brushing with a laser Doppler Flowmeter (LDF).

That is, the change in gum blood flow rate was measured using LDF (Laser Doppler Flowmeter, Perimed System 5000) at the stage of 3 months after the test for the patients in Effect Test Example 1, and the result was measured by t-verification. And the effect of the toothpaste composition prepared in Comparative Example was compared. The results are shown in Table 4 below.

division Example Comparative example One 2 3 4 5 6 7 Before brushing 11.4 ± 1.5 11.9 ± 1.6 12.3 ± 1.6 12.5 ± 1.5 10.3 ± 1.7 11.5 ± 1.5 10.7 ± 1.6 11.8 ± 1.5 After brushing 19.4 ± 1.5 26.9 ± 1.6 35.9 ± 1.6 34.4 ± 1.5 30.1 ± 1.7 27.9 ± 1.5 34.9 ± 1.6 16.9 ± 1.5 valence p <0.05 p <0.05 p <0.05 p <0.05 p <0.05 p <0.05 p <0.05 -

As can be seen in Table 4, the composition of Examples 1 to 7 containing scrubber cucumber showed a significantly higher gum blood flow promoting effect than the comparative example.

Effect Test Example 3 Comparative Evaluation of Stability of Toothpaste Composition

The toothpaste compositions prepared in Examples and Comparative Examples were stored at room temperature and 40 ° C., respectively, and the state stability of the toothpaste compositions was evaluated at regular intervals according to the following criteria.

Evaluation criteria

◎ Very good: smooth surface, no phase separation, no discoloration, normal toothpaste.

O Relatively good: slight discoloration and only slightly rough surface or slightly poor tube entrance.

∇ relatively poor: phase separation and discoloration.

X Very poor: severe phase separation or discoloration, gas generation or hardening.

time lapse Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative example 1 month Room temperature ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ 40 degrees ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ 3 months Room temperature ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ 40 degrees ◎ ◎ ◎ ◎ ◎ ◎ ◎ ○ 6 months Room temperature ◎ ◎ ◎ ◎ ◎ ◎ ◎ ○ 40 degrees ○ ○ ○ ○ ○ ○ ○ ∇ 12 months Room temperature ◎ ◎ ◎ ◎ ◎ ◎ ◎ ∇ 40 degrees ○ ○ ○ ○ ○ ○ ○ ∇

As can be seen from Table 5, the compositions for oral cavity according to the present invention of Examples 1 to 7 were evaluated to secure a level of stability equal to or higher than that of the composition prepared in Comparative Example in state stability. From these results, the composition for oral cavity according to the present invention is excellent in oral inflammation relieving effect and gum blood flow promoting effect, compared to the conventional gum disease prevention toothpaste, tooth decay prevention and plaque removal toothpaste, and also in stability It was found to be excellent.

Claims (7)

A composition for oral cavity, comprising a slice or an extract of loofah cucumber, or both. The composition for oral cavity according to claim 1, wherein the slice size of the scrubber cucumber is 1.0 to 6.0 mm. The composition for oral cavity according to claim 1, wherein the slices of the scrubber cucumber are 0.05 to 10% by weight based on the total weight of the composition. The composition for oral cavity of claim 1, wherein the extract of scrubber cucumber is extracted using at least one solvent selected from the group consisting of water, ethanol, methanol, butanol, normal hexane, and 1,3-butylene glycol. The composition for oral cavity according to claim 1, wherein the extract of scrubber cucumber is 0.01 to 2.0 wt% based on the total weight of the composition. The oral composition according to claim 1, further comprising at least one selected from the group consisting of an abrasive, a humectant, a binder, a foaming agent, a sweetening agent, a pH adjusting agent, a preservative, an active ingredient, a fragrance, a brightener, a coloring agent, and a solvent. The composition for oral cavity according to claim 1, wherein the composition for oral cavity has any one formulation selected from the group consisting of toothpaste, mouthwash, mouthwash, gum, candy, mouthwash and mouthwash.