KR20080076260A - Personal care products in tablet or pellet form - Google Patents

Abstract

The present invention relates to a personal care product comprising an active substance having a functional group capable of covalent bonding with hair and / or skin, characterized in that it is in the form of a tablet or pellet containing such active substance and a blowing agent, a disintegrant or a mixture thereof. It is done. The personal care product according to the present invention is capable of keeping the active substance, which is a reactive substance whose reaction activity is significantly reduced by reaction with water, to prevent the deterioration of the functional group, thereby facilitating long-term storage. It is possible to improve convenience and portability. The active substance used in the present invention can provide semipermanent cosmetic properties to the hair and / or skin by covalently binding to the hair and / or skin.

Description

Tablet or pellet type of personal care product

The present invention relates to a personal care product comprising an active substance having a functional group capable of covalently bonding to hair and / or skin, and more particularly, to a personal care product having improved storage stability, ease of use and portability. It is about.

Personal care products refer to products having the effect of cleansing and / or conditioning the skin or hair, and various methods for increasing the effects such as softness, moistness, smoothness, elasticity, etc. along with the cleaning effect have been steadily studied. However, even if the effect is good, in most cases it is a one-off case.

Therefore, research is being conducted on products whose effects on the skin or hair are not limited to one-off but persist permanently. Japanese Patent Laid-Open No. 2004-182731 discloses a method of activating hair without reducing it, having a functional group for covalently bonding the active compound as a cosmetic to hair, and applying it to the hair to form a covalent bond. Patent 2001-513804 describes the fixation of covalent bonds to active compounds after reduction of disulfide bonds in hair. In addition, Korean Patent Publication No. 10-2006-0035343 is a hair coating composition containing a polyethylene glycol derivative, wherein the polyethylene glycol derivative in the composition is covalently bonded to cystine or amine of the hair, so that the surface of the hair is surrounded by a polymer layer. It is described that it can be used as a semi-permanent hair coating composition rather than a one-off by increasing the thickness of the polymer and transferring the positive properties of the polymer to the hair.

However, in the case of an active substance including a functional group capable of covalent bonding with the skin and / or hair, it is necessary to control the moisture in order to maintain the activity of the functional group, otherwise the reaction activity of the functional group may be changed over time. As it becomes lower, it is difficult to maintain the continuous effect through covalent bonds. In addition, the liquid form of the personal care composition has a disadvantage in that handling, such as transportation, storage is inconvenient.

Therefore, the technical problem to be achieved by the present invention is not only can the active substance is covalently bonded to the hair and / or skin to impart a continuous effect on the hair and / or skin, but also the active degradation of the active material reactor is prevented can be stored for a long time To provide a personal care product that is easy to use and store.

In order to achieve the above technical problem, the present invention is an active material having a functional group that can be covalently bonded to the hair and / or skin is replaced by the main chain and the main chain having cosmetic properties; And it provides a personal care product in the form of a tablet (tablet) or pellet (pellet) characterized in that it comprises a disintegrant, a blowing agent or a mixture thereof.

The present invention also provides a personal care product; And it provides a personal care product kit comprising a specific solvent for dissolving and using such a personal care product.

The present invention is to prepare a composition consisting of an active material comprising a functional group capable of covalently bonding to the hair and / or skin and additives to help achieve the object of the present invention in the form of tablets or pellets to prevent deactivation of the functional group, the user To improve the ease of use, disintegrating agents, blowing agents or mixtures thereof in tablets or pellets are readily dissolved in the solvent when in use. The personal care products in tablet or pellet form according to the present invention allow water to be dissolved in a solvent, which is the main substrate, when applied to hair and / or skin, so that the adsorption of the active substance to the hair and / or skin is maximized. These actives can be covalently bound to hair and / or skin to maintain their effects.

Hereinafter, a personal care product in tablet or pellet form according to the present invention will be described in more detail.

The present invention is an active substance having a main chain having a cosmetic characteristic and a functional group which is substituted in the main chain and can be covalently bonded to hair or skin; And disintegrants, blowing agents or mixtures thereof that help dissolve in solvents. The present invention provides a personal care product in the form of tablets or pellets.

The main chain in the active substance which can covalently bond with the hair and / or skin may be washed, trimmed, protected, blocked, moisturized, dyed, pigmented, discolored, restricted, deodorized, preserved, refreshed, depilated, Hair growth, hair loss prevention, wool, anti-inflammatory, fragrance, aroma, whitening, anti-aging, wrinkle improvement, convergence, relaxation, shrinkage, sebum control, exfoliation, antiseptic, anti-inflammatory, yangyang, deodorant, antihistamine, anti-seborrhea, blood circulation, UV It is a substance that gives cosmetically beneficial properties such as blocking and promoting skin metabolism. Such cosmetically beneficial substances include oily or oily materials such as silicones, fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols and ester oils; Surfactants used for the purpose of emulsification, solubilization, etc .; High molecular compounds used for the purpose of moisturizing, thickening, film formation, or the like as a powder thereof; Ultraviolet absorbers; Antioxidants; Metal ion sequestrants; Color materials such as dyes and pigments; Medicines such as vitamins, animal and plant extracts, hormones, enzymes, amino acids, peptides, proteins and the like; Spices; Dye derivatives; Sunscreen ingredients; sugars; Preservatives and the like, but is not limited thereto.

The active substance is preferably a copolymer including a ethylene glycol monomer unit and a propylene glycol monomer unit as a conditioning component, and such conditioning component may be usefully used to impart a continuous moisturizing effect and oiliness to hair or skin. In the case of polyethylene glycol composed only of ethylene glycol monomer units, it has an excellent moisturizing effect but is poor in imparting oily feeling that shows a conditioning effect. The conditioning component in which the propylene glycol monomer unit is introduced into the polymer together with the ethylene glycol monomer unit can provide a moisturizing effect and oiliness at the same time. Copolymers comprising propylene glycol monomer units and ethylene glycol monomer units can be in block, crossover, graft, dendrimer, multibranched, or combinations thereof, so long as the purpose of imparting a moisturizing effect and oiliness is not impaired. Other monomers can be further copolymerized. As will be described later, such a copolymer has a functional group capable of covalent bonding with a residue on the surface of the hair or skin.

The functional group covalently bonded to the hair and / or skin of the active substance is carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine , Isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinimidyl ester, imidazole, oxy Oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitryle compound , Acrylic or methacrylic esters, crotonic acid or its esters (crotonic acid or esters), cinnamic acid or its esters (cinnamic acid or est) er), styrene and derivatives thereof, butadiene, vinyl ether, vinyl ketone, vinyl ketone, maleic acid ester derived from vinyl or activated vinyl, carboxylic acid, acetal Or hemi acetals, disulfides, amino or hemi aminos, cyclic carbonates, lactones, thioractones or azolactones, ketones, general formula RX (R is an alkyl group, an aryl group, an aralkyl group, a ring or Unsaturated rings, and X is I, Br, or Cl), but is not limited thereto. An example of the reaction of a protein residue of the skin or hair with a polymer having a functional group is illustrated in Schemes 1-12 of Korean Patent Publication No. 10-2006-0035343, which is incorporated herein by reference.

Such functional groups are covalently bound to thiol, hydroxyl, carboxyl or amine residues present in the hair or skin.

The active material having such a functional group preferably contains 0.01 to 90% by weight relative to the total weight of the tablet or pellet. If the active material having a functional group is less than 0.01% by weight, the effect is very insignificant problem, when containing more than 90% by weight is difficult to formulate.

Personal care products in tablet or pellet form according to the invention comprise disintegrants, blowing agents or mixtures thereof in order to facilitate dissolution in solvents in use, preferably including blowing agents, more preferably blowing agents and disintegrating agents. do.

As the disintegrant, starch, hydroxyethyl starch, hydroxypropyl starch, lactose, sorbitol powder, mannitol powder, microcrystalline cellulose, hydroxypropyl cellulose, polyprastone, etc. may be used, but is not limited thereto. Such a disintegrant may include 1 to 95% by weight relative to the total weight of the tablet or pellets, when the content of the disintegrant is less than 1% by weight, the disintegrating effect may have a very slight problem, and exceeds 95% by weight If contained, the formulation is difficult. The content of the disintegrant is determined by the desired dissolution rate of the tablet or pellets.

The blowing agent comprises two components of carbonate and acid (preferably organic acid), the content of which blowing agent component can be determined according to the desired dissolution rate of the tablet or pellet.

In the personal care product of the present invention, carbonates that react with acid to form bubbles for promoting dissolution include sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, calcium carbonate, potassium carbonate, magnesium carbonate, calcium hydrogen carbonate, potassium hydrogen carbonate and the like. May be used, but is not limited thereto, sodium bicarbonate (heavy bath, NaHCO ₃ ) is most preferred.

In the personal care product of the present invention, the acid which reacts with carbonate to form bubbles for promoting dissolution includes citric acid, tartaric acid, fumaric acid, succinic acid, adipic acid, maleic acid, acetic acid, ascorbic acid, benzoic acid and formic acid. Fumaric acid, succinic acid, boric acid, phosphoric acid, lactic acid, and the like may be used, but are not limited thereto, and citric acid is most preferred.

In order to further improve storage stability in the personal care products of the present invention, the carbonates or acids may be coated with water-soluble polymers that respectively block contact with other ingredients.

Personal care products in the form of tablets or pellets of the present invention also further comprise conventional additives, such as excipients, binders, glidants, and the like, for preparing tablets or pellets without departing from the object of the present invention. Such tablets or pellets may be prepared by conventional manufacturing methods well known in the art. For example, in the case of tablets, the prepared powder or granules are prepared by tableting in a uniform form using a conventional tableting machine.

The invention also relates to the aforementioned personal care products; And a solvent for dissolving such personal care product in use.

The solvents are water, acid or base components for pH adjustment, thickening components for viscosity adjustment of solvents, conditioning ingredients effective for hair and / or skin, catalysts for enhancing reactivity, chelating ingredients, preservatives, flavors, fragrances or oily conditioning It may include components included in conventional water-soluble preparations, such as surfactants for solubilizing the components.

 More specifically, in the present invention, the solvent used as a dissolving agent in the use of a personal care product is acetic acid, ammonium bicarbonate, ammonium carbonate, ammonium phosphate, Ascorbic Acid, Benzoic Acid, Citric Acid, Formic Acid, Fumaric Acid, Maleic Acid, Potassium Bicarbonate, Podadium Borate, Potassium Carbonate, Potassium Citrate, Potassium Phosphate, Sodium Bicarbonate, Sodium Carbonate, Sodium Citrate, Sodium Puma Latex, succinic acid, sodium succinate, sodium benzoate, sodium acetate, boric acid, sodium borate, phosphoric acid, sodium phosphate, lactic acid, sodium lactate, sodium phosphate (monobasic), sodium phosphate (dibasic), Such as sodium hydroxide Thickening components such as alginate, cellulose derivatives, quence seed gum, pectin, pullulan, xanthan gum, non-gum, carboxyvinyl polymer, acrylic acid polymer, laponite, etc. It may include.

     In addition, the solvent of the second agent included in the kit of the present invention includes a glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, PEG (poly ethylene glycol) (300, 400, 1500, Moisturizing components such as polyhydric alcohols such as polyhydric alcohols, hyaluronic acid salts, maltitol, and amino acids such as pyrrolidone carboxylic acid, and the like, and also include vegetable oils and oil components such as ester oil or olive oil, jojoba oil and silicone. And various hair or skin conditioning ingredients such as vitamins, amino acid derivatives, animal and vegetable extracts, hyaluronic acid, ceramides, collagen, elastin, cationic polymers, cationic surfactants, proteins, peptides, and the like. On the other hand, solubilizers such as POE oleyl alcohol ether to solubilize the oil component in addition to the main components, fragrance, genariol, linariol or vegetable essential oil fragrance having aroma and aroma effect, methyl paraben, ethyl paraben for microbial stability, Preservatives such as propylparaben, methylchloroisothiazolinone, methylisothiazolinone, and antifading agents such as EDTA4 Na and EDTA2 Na for preventing the discoloration or discoloration of the contents may be contained together.

In addition, the tablets or pellets, or the solvent of the present invention may be a catalyst for promoting the reactivity of the active ingredient to react with the hair and / or skin; Anionic, nonionic, cationic or amphoteric surfactants; Sunscreens; Provitamins; Anionic, nonionic, cationic or amphoteric unfixed polymers; Mineral, vegetable or synthetic oils; Ceramides and pseudoceramides; Linear or cyclic, modified or unmodified volatile or nonvolatile silicones; Oxidizing agents; Any component selected from additives conventionally used in cosmetic compositions intended to be applied to hair or skin, such as reducing agents, may be included within the scope of not impairing the object of the present invention.

The active material with the reactor contained in the personal care product of the present invention reacts with hair and / or skin in a reasonably fast time, resulting in covalent bonding. These covalently linked actives do not fall off during normal cleaning due to shampoos, detergents, soaps, etc. and can remain attached to hair and / or skin almost permanently, and such actives on the surface of hair and / or skin It has beneficial functions such as softness, moistness, smoothness, and sun protection.

Hereinafter, examples will be described in order to describe the present invention in more detail. However, embodiments according to the present invention may be modified in many different forms, and the scope of the present invention should not be construed as being limited by the embodiments described below. The embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

<Production of Examples and Comparative Examples>

To prepare a personal care product in the form of tablets with the ingredients and contents shown in Table 1 below. In the case of Example 1-6, the raw materials shown in Table 1 were mixed in a powder state, and tablets having a diameter of 20 mm, a thickness of 4 mm, and a weight of 2.5 g were made using a tableting machine, and Comparative Example 1-6 simply mixed these compositions in powder form. It was.

ingredient Example Comparative example One 2 3 4 5 6 One 2 3 4 5 6 PEG / PPG (800/200) Block Copolymer-hydroxysuccinimidyl ester 10 - - 10 - - 10 - - 10 - - PEG / PPG (800/200) Block Copolymer-maleimide - 10 - - 10 - - 10 - - 10 - PEG / PPG (800/200) Block Copolymer-isocyanate - - 10 - - 10 - - 10 - - 10 NaHC0 ₃ 50 50 50 50 50 50 50 50 50 50 50 50 Citric acid 20 20 20 20 20 20 20 20 20 20 20 20 Sorbitol granules 20 20 20 - - - 20 20 20 - - - Manitol Granules - - - 20 20 20 - - - 20 20 20 Formulation refine powder

In Table 1, PEG / PPG (800/200) means a copolymer having an average molecular weight of 800 and 200, respectively, of the ethylene glycol monomer unit and the propylene glycol monomer unit.

<Evaluation of Examples and Comparative Examples>

After the tablet of Example 1-6 prepared by the above method and the powder of Comparative Example 1-6 were stored at 25 ° C. and 55% relative humidity for one week, two tablets of Example 1-6 were compared. In the case of Example 1-6, 10 g of powder was added to 50 g of a solution of pH 9 prepared in the composition of Table 2 below, and each composition was treated with a hair skein to evaluate moisturizing persistence, thereby deactivating the reactor in response to hair and skin. It was evaluated.

Raw material Content (% by weight) water Input to 100 Sodium Phosphate Dibasic 0.4 Polyquaternium-10 0.5 PEG 400 1.0 Hydrolyzed Wheat Protein 1.0 Methylchloroisothiazolinone Methylisothiazolinone 0.01

Moisturizing Persistence Assessment

For each composition, the moisture retention while hair was dried after shampooing was measured using a hairdresser having a length of 20 cm and a weight of 10 g. The hairdresser prepared first was washed with 5% sodium lauroyl sulfate solution and dried. After dissolving the product of Comparative Example 1-6 or Example 1-6 in 50 g of the liquid composition of Table 2 above, the hairdresser was treated with each solution for 20 minutes and washed with running water. This was repeated 5 times of washing, rinsing and drying with 10% sodium lauroyl sulfate solution and removing water with a towel to add tress and water weight to about 13 g. This hairtress was placed on the balance at 25 ℃ and 55% relative humidity, and after 12 hours, the weight change was measured as moisturizing rate (%) = ((later weight-initial weight) / initial weight) × 100 to confirm the moisturizing effect. The results are shown in Table 3 below.

Initial weight Weight later Later weight-initial weight Moisturizing rate (%) Example 1 10.00 10.23 0.23 2.3 Example 2 10.00 10.27 0.27 2.7 Example 3 10.00 10.24 0.24 2.4 Example 4 10.00 10.25 0.25 2.5 Example 5 10.00 10.28 0.28 2.8 Example 6 10.00 10.30 0.30 3.0 Comparative Example 1 10.00 10.04 0.04 0.4 Comparative Example 2 10.00 10.07 0.07 0.7 Comparative Example 3 10.00 10.05 0.05 0.5 Comparative Example 4 10.00 10.04 0.04 0.4 Comparative Example 5 10.00 10.03 0.03 0.3 Comparative Example 6 10.00 10.05 0.05 0.5

As shown in Table 3, it was evaluated that the embodiments of the tablet form under the same conditions, the moisture retaining power is superior to the comparative examples in the powder state. It can be covalently bonded to the hydrophilic polyethylene / propylene glycol to the hair because it does not lower the functional group activity that reacts with the hair and / or skin when made into tablets, and as a result can exhibit an excellent moisturizing effect even after washing.

As such, a personal care product in the form of tablets or pellets of the present invention in which the active substance is covalently bound to the hair and / or skin and gives a semi-permanently lasting effect is characterized by By keeping it in a dry state and dissolving it in a solvent immediately before use, it is possible not only to prevent the deactivation of the active substance, but also to handle storage and use. In addition, the personal care product in tablet or pellet form of the present invention has a convenience in use that is easy to dissolve in a solvent, including a disintegrant and / or blowing agent.

Claims (7)

An active substance having a main chain having cosmetic properties and a functional group substituted with the main chain and covalently bound to hair or skin; And Disintegrants, blowing agents or mixtures thereof A personal care product in the form of a tablet or pellet, characterized in that it comprises a. The method of claim 1, wherein the functional group is carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, aziridine, isocyanate, Thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylamidazole ), Imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile compound, acrylic acid or methacrylic acid Acrylic or methacrylic esters, crotonic acid or esters thereof, cinnamic acid or esters thereof (cinnamic acid or esters), styrene and derivatives thereof, Vinyl or activated vinyl derived from butadiene, vinyl ether, vinyl ketone, maleic acid ester, carboxylic acid, acetal or hemi acetal, disulfide, amine Or hemiamine, cyclic carbonate, lactone, thioractone or azolactone, ketone and general formula RX (R is an alkyl group, aryl group, aralkyl group, ring or unsaturated ring, X is I, Br or Cl And at least one selected from the group consisting of: a personal care product. The personal care product of claim 1, wherein the functional group is covalently bound to a thiol, hydroxyl, carboxyl or amine residue present in the hair or skin. The personal care product according to claim 1, wherein the main chain is a copolymer comprising an ethylene glycol monomer unit and a propylene glycol monomer unit. The method of claim 1, wherein the disintegrant is any one selected from the group consisting of starch, hydroxyethyl starch, hydroxypropyl starch, lactose, sorbitol powder, mannitol powder, microcrystalline cellulose, hydroxypropyl cellulose and polyprastone. Personal care product characterized by the above. The personal care product of claim 1 wherein the blowing agent consists of a carbonate and an acid. The personal care product of any one of claims 1 to 6; And Solvents used by dissolving the personal care products Personal care product kit comprising a.