KR20060107375A - Wool, hair growth agent - Google Patents
Wool, hair growth agent Download PDFInfo
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- KR20060107375A KR20060107375A KR1020060031432A KR20060031432A KR20060107375A KR 20060107375 A KR20060107375 A KR 20060107375A KR 1020060031432 A KR1020060031432 A KR 1020060031432A KR 20060031432 A KR20060031432 A KR 20060031432A KR 20060107375 A KR20060107375 A KR 20060107375A
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- wool
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- raising agent
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- 210000002268 wool Anatomy 0.000 title claims abstract description 100
- 230000003779 hair growth Effects 0.000 title claims abstract description 62
- 210000004209 hair Anatomy 0.000 claims abstract description 66
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 42
- 235000010855 food raising agent Nutrition 0.000 claims abstract description 40
- 239000000284 extract Substances 0.000 claims abstract description 27
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims abstract description 18
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 18
- 229940114124 ferulic acid Drugs 0.000 claims abstract description 18
- 235000001785 ferulic acid Nutrition 0.000 claims abstract description 18
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims abstract description 18
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 18
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- 235000019165 vitamin E Nutrition 0.000 claims abstract description 18
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims abstract description 17
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 10
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract description 7
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- 235000011187 glycerol Nutrition 0.000 abstract description 5
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract description 5
- 229960000367 inositol Drugs 0.000 abstract description 5
- 239000004006 olive oil Substances 0.000 abstract description 5
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- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 abstract description 5
- 229960000984 tocofersolan Drugs 0.000 abstract description 5
- 229950008882 polysorbate Drugs 0.000 abstract description 3
- 229920000136 polysorbate Polymers 0.000 abstract description 3
- 239000002076 α-tocopherol Substances 0.000 abstract description 3
- 235000004835 α-tocopherol Nutrition 0.000 abstract description 3
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 abstract description 2
- 239000011627 DL-alpha-tocopherol Substances 0.000 abstract description 2
- 229960005150 glycerol Drugs 0.000 abstract 1
- 210000004761 scalp Anatomy 0.000 description 26
- 238000012360 testing method Methods 0.000 description 16
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N DL-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 239000006000 Garlic extract Substances 0.000 description 1
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- 229940087168 alpha tocopherol Drugs 0.000 description 1
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- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- -1 ferulic acid ester Chemical class 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000020706 garlic extract Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
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- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940092258 rosemary extract Drugs 0.000 description 1
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- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
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- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 150000003611 tocopherol derivatives Chemical class 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
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- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
본 발명은 뛰어난 양모·육모효과를 갖는 양모·육모제를 제공하는 것에 관한 것이다.The present invention relates to providing a wool / hair raising agent having excellent wool / hair growth effects.
양모·육모제는 수층과 유층으로 이루어진다. 수층은 알콜, 1,3-부틸렌 글리콜, 글리세린, 이노시톨, 인삼 엑기스, 삼백초 엑기스, 페룰산, 올리브잎 엑기스 및 물을 함유하여 이루어진다. 유층은 d-α-토코페롤(천연)과 dl-α-아세트산토코페롤(합성)로 이루어진 비타민 E, 올리브 오일, 올리브 스쿠알란, 오리자놀, 폴리소르베이트를 함유하여 이루어진다. Wool and hair-growing agents consist of an aqueous layer and an oil layer. The aqueous layer consists of alcohol, 1,3-butylene glycol, glycerin, inositol, ginseng extract, 300 sec extract, ferulic acid, olive leaf extract and water. The oil layer contains vitamin E consisting of d-α-tocopherol (natural) and dl-α-tocopherol (synthetic), olive oil, olive squalane, oryzanol, and polysorbate.
양모, 육모, 삼백초 엑기스, 페룰산, 올리브잎 엑기스, 폴리소르베이트 Wool, hair growth, triticale extract, ferulic acid, olive leaf extract, polysorbate
Description
도 1은 실시예에서 양모·육모제 사용전의 두피의 상태를 확대하여 도시한 설명도이다. Figure 1 is an explanatory view showing an enlarged state of the scalp before using the wool, hair growth agent in the embodiment.
도 2는 실시예에서 양모·육모제 사용후 30일째의 두피의 상태를 도시한 설명도이다. FIG. 2 is an explanatory diagram showing the state of the scalp on the 30th day after using the wool / hair care agent in the Example.
도 3은 실시예에서 양모·육모제 사용후 90일째의 두피의 상태를 도시한 설명도이다. Figure 3 is an explanatory view showing the state of the scalp on the 90th day after using the wool, hair care agent in the Example.
본 발명은 두피 등에 도포함으로써 양모(養毛), 육모(育毛) 및 발모(發毛)의 효과가 얻어지는 양모·육모제에 관한 것이다.TECHNICAL FIELD The present invention relates to a wool and hair growth agent in which the effects of wool, hair growth and hair growth are obtained by applying to the scalp and the like.
종래부터, 여러가지의 식물 엑기스가 양모·육모 성분로서 사용되고 있다. 예를 들면, 인삼 엑기스는 혈행을 촉진시키는 작용 또는 모근, 모모세포(毛母細胞)를 활성화시키는 작용을 갖는 성분으로서, 많이 사용되고 있다. 또한, 비타민 E( 토코페롤)은 항산화작용(활성산소를 제거하는 작용), 혈행 촉진작용, 혈관 확장작용 등을 갖고 있는 것이 공지되어 있다.Conventionally, various plant extracts have been used as wool and hair growth components. For example, ginseng extract is widely used as a component having a function of promoting blood circulation or activating hair roots and hair cells. It is also known that vitamin E (tocopherol) has antioxidant activity (removing free radicals), blood circulation promoting action, vasodilation action and the like.
또한, 예를 들면, 일본 공개특허공보 제(평)5-310526호에서는 페룰산(ferulic acid) 또는 γ-오리자놀을 함유하는 세포 분화 촉진제가 개시되어 있다. 이에 따르면, 생체에 장애를 일으키지 않고, 육모, 발모를 촉진할 수 있다. 또한, 일본 공개특허공보 제(평)5-310526호의 실시예에는 미량의 d-α-토코페롤을 첨가하여 이루어진 세포 분화 촉진제가 기재되어 있다. For example, Japanese Patent Laid-Open No. 5-310526 discloses a cell differentiation promoter containing ferulic acid or γ-orizanol. According to this, hair growth and hair growth can be promoted without causing an obstacle to a living body. In addition, the Example of Unexamined-Japanese-Patent No. 5-310526 describes the cell differentiation promoter which adds trace amount of d- (alpha) -tocopherol.
그러나, 양모·육모효과를 한층 뛰어나게 하는 데는 일본 공개특허공보 제(평)5-310526호 등의 기술로는 불충분하다. 즉, 뛰어난 양모·육모효과를 얻기 위해서는 각 성분의 조합이 중요하고, 각 성분의 배합에 새로운 연구가 필요해진다. However, the technique such as Japanese Patent Application Laid-Open No. Hei 5-310526 is insufficient to further improve the wool and hair-growing effects. That is, the combination of each component is important in order to obtain the outstanding wool and hair growth effect, and new research is required for the combination of each component.
본 발명은 이러한 종래의 문제점을 감안하여 이루어진 것이며, 뛰어난 양모·육모효과를 갖는 양모·육모제를 제공하고자 하는 것이다. This invention is made | formed in view of such a conventional problem, and it aims at providing the wool / hair care agent which has the outstanding wool / hair growth effect.
제1 발명은 인삼 엑기스, 삼백초 엑기스 및 페룰산을 함유하는 식물 엑기스와, 올리브잎 엑기스를 함유함을 특징으로 하는 양모·육모제이다(청구항 1). The first invention is a wool and hair growth agent comprising ginseng extract, triticale extract and ferulic acid plant extract, and olive leaf extract (claim 1).
본 발명의 양모·육모제는 양모, 육모작용을 갖는 인삼 엑기스, 삼백초 엑기 스 및 페룰산을 함유하는 식물 엑기스와, 항산화작용 등을 갖는 올리브잎 엑기스를 함유하고 있다.The wool / hair raising agent of the present invention contains wool, a plant extract containing ginseng extract having a hair growth action, three hundred sec extract and ferulic acid, and an olive leaf extract having an antioxidant action and the like.
따라서, 식물 엑기스에 의한 양모, 육모작용이 올리브잎 엑기스에 의한 항산화작용 등을 받아, 효과적으로 두피에 작용할 수 있다. Therefore, wool and hair growth by plant extracts are subjected to antioxidant activity by olive leaf extract and can effectively act on the scalp.
따라서, 본 발명의 양모·육모제에 따르면, 두발, 속눈썹, 눈썹 등에 대해 뛰어난 양모·육모효과를 나타낼 수 있다. Therefore, according to the wool / hair raising agent of this invention, it can exhibit the outstanding wool / hair growth effect with respect to hair, eyelashes, eyebrows, etc.
제2 발명은 인삼 엑기스, 삼백초 엑기스 및 페룰산을 함유하는 식물 엑기스와, 올리브잎 엑기스를 함유하는 수층과, γ-오리자놀 및 비타민 E를 함유하는 유층으로 이루어짐을 특징으로 하는 양모·육모제이다(청구항 2).The second invention is a wool and hair-growing agent, comprising a plant extract containing ginseng extract, triticale extract and ferulic acid, an aqueous layer containing olive leaf extract, and an oil layer containing γ-orizanol and vitamin E (claims) 2).
본 발명의 양모·육모제는 수층과 유층의 2층으로 이루어지며 사용할 때에는 교반함으로써 수층과 유층을 혼합시킨다. The wool / hair raising agent of this invention consists of two layers, an aqueous layer and an oil layer, and when used, it mixes an aqueous layer and an oil layer by stirring.
그리고, 수층은 양모, 육모작용을 갖는 인삼 엑기스, 삼백초 엑기스 및 페룰산을 함유하는 식물 엑기스와, 항산화작용 등을 갖는 올리브잎 엑기스를 함유하여 이루어진다. 또한, 유층은 항산화작용 및 혈행 촉진작용, 노화 방지작용 등을 갖는 γ-오리자놀 및 비타민 E를 함유하여 이루어진다. The aqueous layer comprises wool, ginseng extract having a hair growth effect, plant extract containing 300 seconds extract and ferulic acid, and olive leaf extract having an antioxidant action and the like. In addition, the oil layer contains γ-orizanol and vitamin E having antioxidant action, blood circulation promoting action, anti-aging action and the like.
따라서, 수층에서 식물 엑기스에 의한 양모, 육모작용이 수층에서 올리브잎 엑기스에 의한 항산화작용 등과, 유층에서 γ-오리자놀 및 비타민 E에 의한 항산화작용 등을 받아, 효과적으로 두피에 작용할 수 있다. Therefore, wool and hair growth by plant extracts in the aqueous layer may be subjected to antioxidant activity by olive leaf extract in the aqueous layer, and antioxidant activity by γ-orizanol and vitamin E in the oil layer, and may effectively act on the scalp.
따라서, 본 발명의 양모·육모제에 의해서도, 두발, 속눈썹, 눈썹 등에 대해 뛰어난 양모·육모효과를 나타낼 수 있다. Therefore, the wool / hair growth agent of the present invention can also exhibit excellent wool / hair growth effects for hair, eyelashes, eyebrows and the like.
또한, 제1, 제2 발명에서 말하는 양모·육모효과란 양모 및 육모의 효과를 말할 뿐만 아니라, 발모의 효과도 포함시켜 말한다. In addition, the wool and hair-growth effect referred to in the 1st, 2nd invention says not only the effect of wool and hair growth, but also the effect of hair growth.
[발명을 실시하기 위한 최선의 형태] Best Mode for Carrying Out the Invention
상기한 본 발명에서 바람직한 실시 형태에 관하여 설명한다. Preferred embodiments of the present invention described above will be described.
제1, 제2 발명에서 삼백초 엑기스란 삼백초(삼백초과)의 전체 초본으로부터 추출한 것을 말한다. 또한, 페룰산으로서는 페룰산 자체 또는 이의 유도체의 하나 이상을 사용할 수 있다. 또한, 상기 올리브잎 엑기스는 물푸레 나무과의 올리브 잎으로부터 추출한 것으로 할 수 있다. In the first and second inventions, the three hundred second extract refers to an extract extracted from the whole herb of three hundred seconds (over three hundred). As ferulic acid, one or more of ferulic acid itself or a derivative thereof can be used. The olive leaf extract may be extracted from an olive leaf of the ash tree.
또한, 제2 발명에서 γ-오리자놀이란 페룰산에스테르를 함유하는 것을 말한다. 또한, 비타민 E로서는 천연 또는 합성의 어느 것도 사용할 수 있으며. 토코페롤 또는 아세트산토코페롤 등의 토코페롤 유도체의 하나 이상으로 할 수 있다. 또한, 비타민 E는 α-토코페롤, 아세트산-α-토코페롤 등의 α체로 하는 것이 바람직하다. In addition, in 2nd invention, (gamma) -orizonol means what contains a ferulic acid ester. As the vitamin E, either natural or synthetic can be used. At least one of tocopherol derivatives, such as tocopherol or tocopherol acetate. In addition, it is preferable to make vitamin E into alpha bodies, such as alpha-tocopherol and acetic acid alpha-tocopherol.
또한, 양모·육모제는 보습제를 함유하는 것이 바람직하다(청구항 2). 이 경우에는 양모·육모제에서 적절한 보습효과를 얻을 수 있다. Moreover, it is preferable that a wool / hair raising agent contains a moisturizing agent (claim 2). In this case, proper moisturizing effect can be obtained from wool and hair restorer.
또한, 보습제는 예를 들면, 이노시톨, 1.3BG(1,3-부틸렌 글리콜), 글리세린, 프로필렌글리콜, 소르비톨 등의 하나 이상으로 할 수 있다. The moisturizing agent may be, for example, at least one of inositol, 1.3BG (1,3-butylene glycol), glycerin, propylene glycol, sorbitol and the like.
또한, 양모·육모제는 알콜을 함유하고 있으며, 양모·육모제의 전체에 대한 알콜의 배합율은 3 내지 10중량%인 것이 바람직하다(청구항 3).Moreover, it is preferable that the wool / hair raising agent contains alcohol, and the compounding ratio of alcohol with respect to the whole wool and hair raising agent is 3 to 10 weight% (claim 3).
이 경우에는, 양모·육모제의 전체에 대한 알콜의 배합율을 3 내지 10중량%로 적게 억제함으로써 양모·육모제에 의한 양모·육모효과를 한층 뛰어나게 할 수 있다. In this case, by suppressing the compounding ratio of the alcohol to the whole of the wool / hair care agent to 3 to 10% by weight, the wool / hair growth effect by the wool / hair care agent can be further improved.
그런데, 알콜은 식물 엑기스 및 올리브잎 엑기스의 용매로 할 수 있는 한편, 휘발성을 갖고 있으며, 두피에 자극을 준다. 따라서, 알콜의 배합율은 10중량% 이하로 하는 것이 바람직하다. 한편, 알콜의 배합율이 3중량% 미만으로 되면, 식물 엑기스 및 올리브잎 엑기스 등을 양모·육모제 중 또는 수층 중에 함유시키는 것이 곤란해진다. By the way, alcohol can be used as a solvent of plant extract and olive leaf extract, while being volatile and irritating the scalp. Therefore, it is preferable to make the compounding ratio of alcohol into 10 weight% or less. On the other hand, when the blending ratio of alcohol is less than 3% by weight, it is difficult to contain plant extracts, olive leaf extracts, and the like in the wool / hair raising agent or in the aqueous layer.
또한, 알콜로서는 예를 들면, 에틸 알콜(에탄올) 등을 사용할 수 있다. Moreover, ethyl alcohol (ethanol) etc. can be used as alcohol, for example.
또한, 양모·육모제는 올리브 스쿠알란을 함유하는 것이 바람직하다(청구항 4). 이 경우에는, 양모·육모제에서 올리브 스쿠알란에 의한 보습효과, 두피의 유연효과, 산화 피지의 용해효과, 알콜분의 자극 완화효과 등을 얻을 수 있다. Moreover, it is preferable that a wool / hair raising agent contains olive squalane (claim 4). In this case, the moisturizing effect of olive squalane, the softening effect of the scalp, the dissolving effect of oxidized sebum, the stimulating effect of alcohol content, etc. can be obtained in the wool / hair raising agent.
또한, 올리브 스쿠알란은 물푸레 나무과의 올리브의 과실로부터 추출한 오일로 할 수 있다.In addition, olive squalane can be used as the oil extracted from the fruit of the olive of the ash tree.
또한, 양모·육모제는 올리브 오일을 함유하는 것이 바람직하다. 이 경우에는 양모·육모제에서 보습효과 등을 한층 향상시킬 수 있다.Moreover, it is preferable that a wool / hair growth agent contains olive oil. In this case, the moisturizing effect and the like can be further improved in the wool / hair raising agent.
또한, 유층에서 비타민 E의 배합율은 1 내지 5중량%인 것이 바람직하다(청구항 5). 이 경우에는 비타민 E의 배합율을 1 내지 5중량%로 많게 함으로써 한층 뛰어난 양모·육모효과를 얻을 수 있다.In addition, the blending ratio of vitamin E in the oil layer is preferably 1 to 5% by weight (claim 5). In this case, by further increasing the blending ratio of vitamin E to 1 to 5% by weight, an excellent wool and hair growth effect can be obtained.
또한, 유층은 분산제를 함유하는 것이 바람직하다(청구항 6). 이 경우에는 분산제에 의해 수층 중에서 유층을 용이하게 분산시킬 수 있다. Moreover, it is preferable that an oil layer contains a dispersing agent (claim 6). In this case, an oil layer can be easily disperse | distributed in an aqueous layer with a dispersing agent.
분산제로서는, 예를 들면, 폴리소르베이트, 올레산소르비탄, PEG-40 수소첨가 피마자유 등을 사용할 수 있다.As a dispersing agent, polysorbate, sorbate oleate, PEG-40 hydrogenated castor oil, etc. can be used, for example.
[실시예]EXAMPLE
다음에 본 발명의 양모·육모제에 따른 실시예에 관해 도면과 함께 설명한다. Next, the Example which concerns on the wool, the hair raising agent of this invention is demonstrated with drawing.
본 발명의 예의 양모·육모제는 인삼 엑기스, 삼백초 엑기스 및 페룰산을 함유하는 식물 엑기스, 올리브잎 엑기스를 함유하는 수층, γ-오리자놀 및 비타민 E를 함유하는 유층으로 이루어진다. The wool / hair raising agent of the example of this invention consists of a ginseng extract, a plant extract containing a three hundred sec extract, and a ferulic acid, an aqueous layer containing an olive leaf extract, an oil layer containing (gamma) -orizanol and vitamin E.
하기에 본 발명의 예의 양모·육모제를 상세하게 설명한다. The wool / hair raising agent of the example of this invention is demonstrated in detail below.
본 발명의 예의 수층은 알콜, 1,3-부틸렌 글리콜(보습제), 글리세린(보습제), 이노시톨(보습제), 삼백초 엑기스(양모·육모 성분), 페룰산(양모·육모 성분), 올리브잎 엑기스(항산화제), 방부제, 착향료 및 물을 함유하여 이루어진다. The aqueous layer of the example of this invention is alcohol, 1, 3- butylene glycol (humidifier), glycerin (humidifier), inositol (humidifier), three hundred sec extract (wool, hair growth component), ferulic acid (wool, hair growth component), olive leaf extract (Antioxidant), antiseptic, flavor and water.
또한, 본 발명의 예의 유층은 d-α-토코페롤(천연)과 dl-α-아세트산토코페롤(합성)으로 이루어진 비타민 E(항산화작용, 혈행 촉진작용, 노화 방지작용 등), 올리브 오일(보습작용, 두피의 유연작용, 산화 피지의 용해작용, 알콜분의 자극 완화작용 등), 올리브 스쿠알란(보습작용, 두피의 유연작용, 산화 피지의 용해작용, 알콜분의 자극 완화작용 등), 오리자놀(항산화작용, 혈행 촉진작용, 노화 방지작용 등) 및 분산제를 함유하여 이루어진다. In addition, the oil layer of the example of the present invention is vitamin E (antioxidation, blood circulation promoting, anti-aging, etc.) consisting of d-α-tocopherol (natural) and dl-α-tocopherol (synthesis), olive oil (moisturizing, Softening of the scalp, dissolution of oxidized sebum, stimulation of alcohol content, etc.), olive squalane (moisturizing, softening of the scalp, dissolution of oxidized oil, stimulation of alcohol content, etc.), orrizol , Blood circulation promoting action, anti-aging action) and dispersant.
또한, 수층은 상기 성분 이외에, 다음의 양모·육모 성분을 함유하여 이루어진다. 이러한 양모·육모 성분은 인삼 엑기스, 모란 엑기스, 참피나무 엑기스, 연명초 엑기스, 광대 수염 엑기스, 아루니카 엑기스, 화란 겨자 엑기스, 우엉 엑기스, 서양 노랑별 풀 엑기스, 마늘 엑기스, 소나무 엑기스, 로즈마리 엑기스 및 로마 카밀레 엑기스를 함유하는 것이다. In addition to the above components, the aqueous layer contains the following wool and hair growth components. These ingredients include ginseng extract, peony extract, basswood extract, lotus extract, clown beard extract, arunicar extract, fever mustard extract, burdock extract, western yellow starch extract, garlic extract, pine extract, rosemary extract and It contains Roman camomile extract.
또한, 본 발명의 예의 수층에서 알콜의 배합율은 양모·육모제의 전체에 대하여 10중량%로 되어 있다. 또한, 유층에서 비타민 E의 배합율은 양모·육모제의 전체에 대하여 4중량%로 되어 있다. In addition, in the water layer of the example of this invention, the compounding ratio of alcohol is 10 weight% with respect to the whole wool and hair raising agent. In addition, the compounding ratio of vitamin E in an oil layer is 4 weight% with respect to the whole wool and hair raising agent.
본 발명의 예의 양모·육모제를 제조함에서는 γ-오리자놀, 비타민 E 등의 각 유층 성분을 계량하여 혼합하며, 이러한 혼합물을 가열하여 균일하게 용해하며, 유층분으로 한다. 또한, 알콜, 인삼 엑기스, 삼백초 엑기스, 페룰산 및 올리브잎 엑기스 등의 각 수층 성분을 물에 가하여 혼합하며, 이러한 혼합물을 균일하게 용해하여, 수층분으로 한다. 다음에 유층분을 교반하면서 수층분에 가하여, 이것을 믹서에 걸어 균일하게 분산시켜 유화상의 양모·육모제를 제조한다. 다음에 이러한 양모·육모제는 예를 들면, 보관용, 시판용 등의 빈 등에 투입한다.In the production of the wool / hair raising agent of the example of the present invention, each oil layer component such as γ-orizanol and vitamin E is weighed and mixed, and the mixture is heated to be uniformly dissolved to form an oil layer powder. In addition, each aqueous layer component such as alcohol, ginseng extract, triticale extract, ferulic acid and olive leaf extract is added to water and mixed, and the mixture is dissolved uniformly to form a water layer. Next, the oil layer powder is added to the water layer powder while stirring, which is then uniformly dispersed in a mixer to prepare an emulsified wool / hair raising agent. Next, such a wool / hair raising agent is put into bins, such as storage and commercial use, for example.
또한, 양모·육모제는 방치하면 수층과 유층으로 분리되므로 교반 혼합하고 나서(예: 양모·육모제가 들어간 빈 등을 잘 흔들고 나서) 두피 등에 사용한다. In addition, the wool and hair restorer is separated into an aqueous layer and an oil layer when it is left, and is used after scrubbing and mixing (for example, by shaking a blank containing a wool and hair raising agent well).
당해 예의 양모·육모제는 피부에 좋은 성분을 배합하여, 두피를 건강한 상태로 함으로써 머리털의 트러블을 해소하는 것이다. The wool / hair raising agent of the said example mix | blends the components which are good for skin, and removes the trouble of a hair by bringing a scalp to a healthy state.
당해 예의 양모·육모제에서 수층 및 유층을 구성하는 각 성분의 원료명 및 배합율(중량%)을 표 1에 기재한다. 당해 예의 수층 및 유층을 구성하는 각 성분의 원료명 및 배합율은 발명자가 연구·시험을 거듭하여 뛰어나게 양모·육모효과를 갖는 것을 확인 시험한 것이다. Table 1 shows raw material names and blending ratios (% by weight) of the components constituting the aqueous layer and the oil layer in the wool / hair raising agent of the example. The raw material name and compounding ratio of each component which comprise the water layer and the oil layer of the said example are the test which confirmed that the inventor had the wool and hair-growth effect outstanding repeatedly by research and test.
(두발의 확인 시험) (Confirmation test of the hair)
하기에 본 발명의 예의 양모·육모제를 수인의 피시험자의 두피에 도포하여, 양모·육모효과를 확인한 예를 기재한다. Below, the example which applied the hair and hair growth agent of the example of this invention to the scalp of several test subjects, and confirmed the wool and hair-growth effect is described.
본 확인 시험에서는 피시험자는 객관적으로 탈모증이라고 알 수 있는 사람으로 하며, 10명의 피시험자에 대해 두피에서 탈모 부분을 습하게 할 정도로 양모·육모제를 매일 1회 도포한다. 그리고, 1주째, 2주째, 30일째, 60일째, 90일째에 두피에 생긴 변화를 표 2에 기재한다. In this confirmatory test, the subjects are objectively known as alopecia, and 10 subjects are applied with a wool and hair growth agent once daily to moisten the hair loss part of the scalp. Table 2 shows changes in the scalp at 1 week, 2 weeks, 30 days, 60 days, and 90 days.
표 2에서 △는 빠진 모발의 감소, 머리털의 윤기의 증가, 두피의 붉은 빛 또는 검버섯의 감소 등의 효과를 확인할 수 있는 것을 나타낸다. 또한, ○은 양모, 육모 또는 발모(새로운 모발의 발생, 모발의 성장 등)을 확인할 수 있는 것을 나타낸다. 또한, ◎은 모발이 충분하게 성장하는 동시에 이의 수도 증가하여, 탈모 부분의 일부가 통상적인 보통의 두발로 된 것을 나타낸다. △ in Table 2 indicates that the effect of the reduction of the missing hair, the increase in the gloss of the hair, the red light of the scalp or the reduction of the mushrooms can be confirmed. ○ indicates that wool, hair growth or hair growth (new hair development, hair growth, etc.) can be confirmed. Also,? Indicates that the hair grows sufficiently and at the same time, the number thereof increases, so that a part of the hair loss part is made of ordinary ordinary hair.
동표에서 10명의 피시험자 중에 1명에 관해서는 2주째, 5명에 관해서는 30일째에 양모, 육모 또는 발모의 효과가 확인될 수 있다. 또한, 모든 피시험자에 관해 90일째에는 양모, 육모 또는 발모의 효과를 확인할 수 있다. 또한, 모든 피시험자에 관해 1주째에는 빠진 모발의 감소, 두피의 개선 등의 무엇인가의 효과를 확인할 수 있다. 본 결과에서 양모·육모제에 따르면 뛰어난 양모·육모효과를 나타낼 수 있는 것을 알았다. In the table, the effect of wool, hair growth, or hair growth can be confirmed at 2 weeks for 1 out of 10 subjects and 30 days for 5 people. In addition, the effects of wool, hair growth or hair growth can be confirmed on day 90 for all subjects. In addition, all the subjects can confirm the effects of any hair loss and improvement of the scalp at the first week. In this result, it was found that according to the wool and hair raising agent, it could exhibit excellent wool and hair growth effects.
또한, 도 1 내지 도 3에는 상기 피시험자 중의 1명에 관해 양모·육모제를 사용할 때에 두발의 발모, 육모의 상태를 나타내는 사진이다. 각 도면에서 흑색의 대략 직선상의 부분이 머리털을 나타내며, 기타 회색 부분이 두피을 나타낸다. 또한, 각 도면의 사진은 직경 3 mm의 렌즈에 의한 200배의 스코프 사진이다. 1 to 3 are photographs showing the state of hair growth and hair growth of hair when one of the test subjects uses the wool / hair growth agent. In each figure, the black approximately straight portion represents the hair and the other gray portion represents the scalp. In addition, the photograph of each figure is 200 times the scope photograph by the lens of diameter 3mm.
도 1은 양모·육모제를 사용하기 전의 두피 상태를 나타내는 사진이며, 연약한 머리털이 2, 3개 보이는 정도이며, 두피도 붉은 빛을 띄는 상태를 나타내고 있다. 1 is a photograph showing the state of the scalp before using the wool and hair-growing agent, and shows two or three fragile hairs, and the scalp also shows a reddish state.
도 2는 양모·육모제의 사용을 개시하고 나서 30일째의 두피의 상태를 나타내는 사진이며, 두피의 붉은 빛이 감소되며 또한 머리털이 이의 개체수가 증가하는 동시에 굵어지는 상태를 나타내고 있다. Fig. 2 is a photograph showing the condition of the scalp on the 30th day after the use of the wool / hair raising agent, showing the reddish color of the scalp, and the hairs being thickened at the same time as their population increased.
도 3은 양모·육모제의 사용을 개시하고 나서 90일째의 두피 상태를 나타내는 사진이며, 머리털이 한층 굵어지고 통상적인 보통의 굵기까지 성장하고 있는 상태를 나타내고 있다. Fig. 3 is a photograph showing the state of the scalp on the 90th day after the use of the wool / hair raising agent, showing a state in which the hair grows thicker and grows to the usual normal thickness.
이들 사진으로부터도 알 수 있는 바와 같이 양모·육모제에 의한 양모·육모효과는 뛰어난 것을 확인할 수 있다. As can be seen from these photographs, it can be confirmed that the wool / hair growth effect by the wool / hair raising agent is excellent.
(두발의 비교 확인시험)(Comparison confirmation test of hair)
본 비교 확인시험에서는 실시예 1의 양모·육모제(발명품)에서의 뛰어난 양모·육모효과와 비교하기 위해 올리브잎 엑기스, 페룰산, 비타민 E 및 γ-오리자놀을 함유하지 않는 양모·육모제(비교품)에 관해서도 확인 시험을 실시한다.In this comparative confirmation test, in order to compare with the excellent wool and hair growth effects of the wool and hair growth agent (invention) of Example 1, wool and hair growth agent (comparative product) containing no olive leaf extract, ferulic acid, vitamin E and γ-orizanol The verification test is also conducted.
비교품에서 수층 및 유층을 구성하는 각 성분의 원료명 및 배합율(중량%)을 표 3에 기재한다. Table 3 shows raw material names and blending ratios (% by weight) of the components constituting the water layer and the oil layer in the comparative product.
본 비교 확인시험에서는 피시험자는 객관적으로 탈모증이라고 알 수 있는 사람으로 하며, 5명의 피시험자에 대해 두피에서 탈모 부분을 습하게 할 정도로 비교품을 매일 1회 도포한다. 그리고, 30일째, 60일째, 90일째에 두피에 생긴 변화를 표 4에 기재한다. In this comparative confirmation test, the test subjects are objectively identified as alopecia, and 5 test subjects apply a comparative product once daily to moisten the hair loss part of the scalp. And the change in the scalp on the 30th, 60th and 90th day is shown in Table 4.
표 4에서 -는 별로 변화를 확인할 수 없음을 나타낸다. △는 빠진 모발의 감소, 두피의 붉은 빛 또는 검버섯의 감소 등의 효과를 확인할 수 있음을 나타낸다. -In Table 4 indicates that the change cannot be confirmed very much. Δ indicates that effects such as reduced hair loss, redness of the scalp, or a reduction of spots can be confirmed.
동표에서 5명의 피시험자 중의 4명에 관해서는 90일째에 빠진 모발의 감소, 두피의 붉은 빛 또는 검버섯의 감소 등의 효과를 확인할 수 있지만, 모든 피시험자에 관해 90일째에도 양모, 육모 또는 발모의 효과를 확인할 수 없다. In the table, 4 of 5 test subjects can see the effects of hair loss on day 90, redness of scalp, or blemishes, but not on day 90 of all subjects. The effect cannot be confirmed.
본 결과로부터 올리브잎 엑기스, 페룰산, 비타민 E 및 γ-오리자놀을 함유하지 않는 양모·육모제(비교품)에서는 뛰어난 양모·육모효과를 나타낼 수 없음을 알았다. From the results, it was found that the wool and hair growth agent (comparative product) containing no olive leaf extract, ferulic acid, vitamin E and γ-orizanol could not exhibit excellent wool and hair growth effects.
(속눈썹의 확인 시험) (Confirmation test of eyelashes)
또한, 양모·육모제의 속눈썹에 대한 효과의 확인 시험도 실시한다. 본 확인 시험에서는 10명의 여성 피시험자에 대해 속눈썹이 돋아나는 부분을 습기차게 할 정도로 매일 1회 도포한다. 그리고, 1주째, 2주째, 3주째, 3주째, 60일째에 속눈썹이 생기는 변화를 표 5에 기재한다. In addition, a confirmation test of the effect on the eyelashes of the wool and the hair raising agent is also performed. In this test, 10 female subjects were applied once daily to moisten their lashes. In Table 5, changes in eyelashes occurring at the first, second, third, third, and sixty days are described.
표 5에서 -는 별로 변화를 확인할 수 없는 것을 나타낸다. 또한, △는 속눈썹이 튼튼하게 나오고 빠지기 어렵게 되는 등의 효과를 확인할 수 있는 것을 나타낸다. ○는 속눈썹의 양모, 육모 또는 발모(새로운 모발의 발생, 모발의 성장 등)를 확인할 수 있는 것을 나타낸다. 또한, ◎은 속눈썹 전체가 짙어지는 동시에 길어지고, 속눈썹 전체의 볼륨이 증가되는 것을 나타낸다.-In Table 5 indicates that the change cannot be confirmed very much. In addition, (triangle | delta) shows that the effect that a lashes are firmly come out and it is hard to fall out is confirmed. ○ indicates that the eyelashes, hair growth or hair growth (new hair development, hair growth, etc.) of the eyelashes can be confirmed. In addition, (double-circle) shows that the whole eyelashes become thick and long, and the volume of the whole eyelashes increases.
동표에서 10명의 피시험자 중에 2명에 관해서는 2주째에 9명에 관해서는 30일째에 속눈썹의 양모, 육모 또는 발모의 효과를 확인할 수 있다. 또한, 모든 피시험자에 관해 4주째에는 양모, 육모 또는 발모의 효과를 확인할 수 있으며 또한 60일째에는 속눈썹 전체의 볼륨 증가의 효과를 확인할 수 있다. In this table, the effect of eyelash wool, hair growth, or hair growth on eyelashes can be confirmed for 2 out of 10 subjects and 2 days for 9 weeks and 30 days for 9 patients. In addition, for all subjects, the effect of wool, hair growth, or hair growth can be confirmed at 4 weeks, and at 60 days, the effect of increasing the volume of the entire eyelashes can be confirmed.
본 결과로부터 양모·육모제에 따르면 속눈썹에 대하여도 뛰어난 양모·육모효과를 나타낼 수 있는 것을 알았다. 또한 상세한 것은 생략하지만, 양모·육모제에 따르면 눈썹에 대하여도 뛰어난 양모·육모효과를 나타낼 수 있는 것을 알았다. From the results, it was found that according to the wool and hair-growing agent, it is possible to exhibit excellent wool and hair-growing effects on the eyelashes. Although details are omitted, it has been found that according to the wool / hair raising agent, excellent wool / hair growth effects can be exhibited on the eyebrows.
본 발명에 의해 뛰어난 양모·육모효과를 갖는 양모·육모제가 제공된다.According to the present invention, there is provided a wool / hair raising agent having excellent wool / hair growth effects.
Claims (7)
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| Application Number | Priority Date | Filing Date | Title |
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| JP2005111119A JP2006290767A (en) | 2005-04-07 | 2005-04-07 | Hair-fostering/growing agent |
| JPJP-P-2005-00111119 | 2005-04-07 |
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| KR102120245B1 (en) * | 2019-11-01 | 2020-06-08 | 변은진 | Method for operating eyebrow growth |
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| US8632816B2 (en) | 2007-12-17 | 2014-01-21 | Elc Management, Llc | Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same |
| US20100040696A1 (en) * | 2008-08-12 | 2010-02-18 | Ilse Sente | Composite Particles Having An Antioxidant-Based Protective System, And Topical Compositions Comprising The Same |
| JP5872752B2 (en) * | 2009-02-19 | 2016-03-01 | 株式会社ツツミプランニング | Hair nourishing agent with ability to dissolve sebum cured product |
| WO2012068714A1 (en) * | 2010-11-22 | 2012-05-31 | Chen Han-Min | Hair growth promoter |
| JP6011128B2 (en) * | 2011-08-09 | 2016-10-19 | 花王株式会社 | Emulsified cosmetic for eyebrows or eyelashes |
| JP6192036B2 (en) * | 2013-05-14 | 2017-09-06 | オリザ油化株式会社 | Raw materials for eyelash cosmetics and eyelash cosmetics using the same |
| JP2014208714A (en) * | 2014-08-13 | 2014-11-06 | 株式会社ツツミプランニング | Hair tonic with dissolution ability of sebum-hardened product blocking pore |
| CN106999402B (en) * | 2014-10-09 | 2020-10-27 | 梅迪普罗都司股份有限公司 | eyelash cleaner |
| KR102093040B1 (en) | 2018-10-31 | 2020-05-22 | 김현수 | Composition for external use for hair growth and hair growth |
| IT202300003315A1 (en) * | 2023-02-24 | 2024-08-24 | Giuliani Spa | COMPOSITION TO IMPROVE THE AESTHETIC APPEARANCE OF HAIR AND PROMOTE ITS GROWTH |
| IT202300003327A1 (en) * | 2023-02-24 | 2024-08-24 | Giuliani Spa | COMPOSITION TO IMPROVE THE AESTHETIC APPEARANCE OF HAIR AND PROMOTE ITS GROWTH |
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| JPH05310526A (en) * | 1992-05-07 | 1993-11-22 | Eisai Co Ltd | Cell differentiation promotor |
| JPH0725731A (en) * | 1993-07-08 | 1995-01-27 | Kyodo Kumiai Ratesuto | Hair tonic |
| JPH1017440A (en) * | 1996-07-02 | 1998-01-20 | Hoyu Co Ltd | Hair growing and restoring agent |
| JP4083831B2 (en) * | 1996-11-20 | 2008-04-30 | 株式会社カネボウ化粧品 | Skin preparation |
| JP2001288048A (en) * | 2000-03-31 | 2001-10-16 | Shiseido Co Ltd | Composition for scalp and hair |
| JP4093735B2 (en) * | 2000-06-13 | 2008-06-04 | 花王株式会社 | Emulsified external skin preparation |
| JP4321955B2 (en) * | 2000-08-22 | 2009-08-26 | 株式会社マンダム | Hair restorer composition |
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