KR20030092696A - The formulation and preparation of antiinflammatory & poulticing plaster and various topical products - Google Patents

Abstract

The present invention contains glycol, salicylic acid glycol, camphor, ketoprofen, hulubipropene, pyrocampam, and the like, which are pharmacologically active substances such as mugwort, or baekbaek, gardenia, horse chestnut seed extract, etc. Anti-inflammatory analgesic, poultice, prepared by the usual method by adding skin irritants such as vanyl butyl ether, benzyl nicotinate, tocopherol nicotinate, vigor, garlic, ginger, and gardenia The present invention relates to a patch or other external agent that provides a moxibustion effect, or to a patch or other external agent such as gels, creams, ointments and sprays, prepared by adding a self-heating material such as zeolite, activated carbon, alumina, silica gel and bentonite Anti-inflammatory analgesic, poultice, moisturizing patch or other external preparations such as gels, creams, ointments and sprays. The anti-inflammatory analgesic adhesive patch which provides, poultice, moxibustion effects will first or on other external application of a gel, cream, ointment, spray or the like.

Description

Compositions and preparation methods of anti-inflammatory analgesic, steaming and moxibustion of new composition or other external preparations such as gels, creams, ointments and sprays, and methods for preparing the same {The formulation and preparation of antiinflammatory & poulticing plaster and various topical products}

The present invention is a patch containing wormwood, salicylic acid glycol, camphor, ketoprofen, hulubipropene, pyrocampum, etc., of medicinal herbs or anti-inflammatory analgesic ingredients such as mugwort, yellow white, gardenia, horse chestnut seed extract, etc. Or other external preparations such as gels, creams, ointments, sprays, etc., new antimicrobial analgesic, steaming, moisturizing agents or gels, creams, ointments, sprays, etc. It relates to a composition of other external preparations and a method for producing the same.

In particular, the wormwood, called wormwood, is called Ae-yeop (艾葉), which has a warm scent, and enters the trigeminal penis, which warms the blood vessels and warms the humidity. ) To remove the cold container (冷 痛).

Mugwort has been used for a variety of purposes, such as treatment of sub-digestive blood (허 下 血), cold cold pain (虛寒 冷 痛), skin eczema (皮膚 濕疹).

In addition, moxibustion moxibustion is used for promoting the warm energy and blood circulation of wormwood along with the heat stimulation caused by the burning of wormwood to promote the function of tissue cells, cardiac blood, immunity, and pain treatment. Especially, wormwood is called wormwood steamed arthritis or stiffness It is still frequently used in the treatment of arthritis or stiffness by steaming the area.

The mugwort steaming pack is developed to make it easier to use. This is a mugwort steaming method designed to be more portable and reusable by putting mugwort together in a pack containing a pyrogenic object.

However, since it contains a pyrogenic substance and shows high temperature up to 80 ℃, it may cause burns.However, it can be used several times.However, if a lump occurs, it is difficult to reuse.If a small hole is generated in the pack due to excessive force during heating, There is a disadvantage that can not be.

It is an object of the present invention to provide a wormwood patch that can be used by adhering to the skin surface of arthritis or stiff areas without side effects.

In light of this, the present inventors have completed the present invention by discovering that an external patch for adhering and acting on the skin surface of arthritis or stiffening area using wormwood as an active ingredient can be safely and simply used instead of wormwood steaming.

The mugwort steamed patch of the present invention contains additives used in the manufacture of conventional patch together with 1 to 30% of mugwort as a main ingredient and 0.001 to 0.5% of skin irritant. Mugwort used in the present invention can be used as it is dried, milled or extracted with water or a suitable organic solvent, or juice obtained by squeezing the wormwood.

Skin irritants are used to give a warm feeling, and there may be used vanylbutyl butyl ether, benzyl nicotinate, tocopherol nicotinate, vigor, garlic, ginger, gardenia and the like which have never been used before.

The mugwort steamed patch of the present invention is prepared by uniformly combining the usual additives such as adsorbents and thickeners used in the manufacture of conventional patch by using mugwort as a main ingredient and skin stimulant as auxiliary ingredients, and then forming the paste on the surface. do.

In detail, one or more components of powdered components such as kaolin, bentonite, zinc oxide, titanium oxide, silicic anhydride, and the like added with one or more components of polyhydric alcohols such as glycerin, sorbitol, and propylene glycol are used as a sorbent.

At least one component of polymer adhesives such as gelatin, gum arabic, alginate, sodium carboxymethyl cellulose, vinyl acetate, acrylic resin, polybutene, polybutene, polyethylene glycol monostearate, polyvinyl alcohol is used as a thickener. .

If necessary, skin protectants such as tocopherol, preservatives, flavors or pigments associated with the main ingredient may be added.

In addition to this, self-heating materials such as zeolite, activated carbon, alumina, silica gel and bentonite can be added to increase the effect of mugwort steaming by adding a heating function.

The present invention provides safe and easy to use anti-inflammatory analgesic, poultice, a patch having a moxibustion effect or other external preparations such as gels, creams, ointments, sprays.

The mugwort steaming patch of the present invention can be easily carried and used conveniently than conventional mugwort steaming or mugwort steaming packs, and can safely exhibit the effects of mugwort steaming without any concern such as burns.

Hereinafter, the present invention will be described with reference to specific examples, but the present invention is not limited only to these examples.

However, the% described in the present specification and examples means weight%.

Example 1

Mugwort X ----------------------------- 10%

Gelatin ---------------------------- 3%

Titanium Oxide ---------------------------- 1%

Glycerin -------------------------- 30%

Polyethylene Glycol Monostearate -------------- 0.1%

Polyvinyl Alcohol ----------------------- 3%

Sodium Polyacrylate ---------------------- 3.5%

Carboxymethyl Cellulose Sodium ----------------- 2.4%

Vanylbutylbutyl ether ---------------------- 0.02%

Salicylic Acid Methyl ------------------------ 2%

Paraoxybenzoic Acid Methyl --------------------- 0.18%

Paraoxybenzoic acid propyl ------------------- 0.02%

Copper Chlorophyll Sodium ----------------------- Correct

Mugwort flavor -----------------------------

Purified Water --------------------------- Proper

After 10 g of titanium oxide was suspended in purified water, 1 g of polyethylene glycol monostearate and 30 g were added thereto, followed by warm dissolution and cooling. Then, 100 g of mugwort extract (based on solids) and an appropriate amount of copper chlorophyll sodium were well mixed.

35 g of sodium carboxymethyl cellulose sodium polyacrylate was dispersed in 300 g of glycerin, 30 g of polyvinyl alcohol was dissolved in a portion of purified water, and 0.2 g of vanyl butyl ether and an appropriate amount of mugwort were dissolved in 20 g of salicylic acid.

Separately, 1.8 g of paraoxybenzoic acid and 0.2 g of propyl paraoxybenzoate were dissolved in a portion of purified water.

The paste was prepared by mixing a salicylic acid methyl solution, a glycerin suspension, a polyvinyl alcohol solution, and a preservative solution in the mugwort-containing purified water admixture.

The paste was well inverted onto a nonwoven fabric and dried at 60 ° C. for 10 minutes to cover the polyethylene film and cut to an appropriate size to prepare a mugwort patch.

Example 2

Mugwort extract ---------------------------- 5%

Kaolin ---------------------------- 6%

Gelatin ---------------------------- 5.9%

Titanium Oxide ---------------------------- 1%

Zeolite --------------------------- 3%

Glycerin --------------------------- 22%

Sorbitol -------------------------- 10%

Carboxymethyl Cellulose Sodium ---------------- 3%

Sodium Polyacrylate --------------------- 3%

Polyethylene Glycol Monostearate ------------- 1%

Vanylbutylbutyl ether ---------------------- 0.005%

Polyvinyl Alcohol ----------------------- 3%

Sodium Polyacrylate --------------------- 3.5%

Benzyl Nicotinate --------------------- 0.04%

Paraoxybenzoic Acid Butyl ------------------ 0.1%

Yellow No. 4 ------------------------- Correct

Blue No. 2 ------------------------- Cumulus

Mugwort flavor ---------------------------

Purified Water -------------------------- Proper

A portion of purified water was dissolved by heating 1.0 g of paraoxybenzoic acid, and a suitable amount of Yellow No. 4 and blue No. 2 were mixed. Was dispersed in 250 g of glycerin.

After 10 g of titanium oxide was suspended in the remaining purified water, 10 g of polyethylene glycol monostearate, 59 g of gelatin, and 100 g of sorbitol were added thereto, followed by warming and suspending 60 g of kaolin.

Mugwort extract 50g (based on solids) was mixed with the admixture, and then mixed with preservatives, a dye solution, and 10g in order, and finally, an appropriate amount of mugwort flavor was mixed to prepare a paste.

This paste was inverted well on a nonwoven fabric to prepare a mugwort steamed patch.

Example 3

Mugwort X -------------------------- 2%

Gelatin ------------------------- 20%

Polyvinyl Alcohol ---------------------- 4.5%

Methyl Cellulose ---------------------- 2%

1,2-propandiol, 3-[[5-methyl-2- (1-methylethyl) cyclohexyl]] --0.5%

Glycerin ------------------------- 30%

Kaolin -------------------------- 15%

Sodium Polyacrylate -------------------- 1%

Polybutene -------------------------- 3%

Tocopherol Acetate ------------------------- 0.3%

Paraoxybenzoic Acid Methyl -------------------- 0.18%

Paraoxybenzoic acid propyl ------------------- 0.02%

Copper Chlorophyll Sodium -----------------------

Mugwort flavor -----------------------------

Purified Water --------------------------- Proper

1.8 g of paraoxybenzoic acid and 0.2 g of paraoxybenzoic acid were dissolved in a portion of purified water under heating, and then cooled. Then, an appropriate amount of copper chlorophyll sodium and 50 g of polyvinyl alcohol were added thereto to dissolve.

Separately, 20 g of methyl cellulose, 10 g of sodium polyacrylate, 30 g of polybutene, and 3 g of tocopherol acetate were added sequentially to 300 g of glycerin and dispersed.

200 g of gelatin was added to the remaining purified water to dissolve it, cooled, and disperse 160 g of kaolin.

Mugwort extract 20g (solid basis) was mixed with this blend, and then mixed with a preservative, a pigment solution, and red pepper x 2g, and finally, an appropriate amount of mugwort flavor was mixed to prepare a paste.

The paste was well inverted onto a nonwoven fabric and dried at 60 ° C. for 10 minutes to cover the polyethylene film and cut to an appropriate size to prepare a mugwort patch.

Example 4

Mugwort X ----------------------------------- 3%

Gelatin --------------------------------- 14%

Polyvinyl Alcohol ------------------------------ 9%

Kaolin ---------------------------------- 12%

Sodium Polyacrylate ---------------------------- 5%

Sorbitol ----------------------------------- 5%

Propylene Glycol ------------------------------- 13%

Vanylbutylbutyl ether --------------------------- 0.03%

Salicylic Acid Methyl -------------------------------- 3%

Diphenhydramine Hydrochloride ---------------------------- 0.05%

Paraoxybenzoic acid butyl --------------------------- 0.1%

Copper Chlorophyll Sodium -----------------------------

Mugwort flavor -----------------------------------

Purified Water ----------------------------------- Proper

140 g of gelatin and 50 g of sorbitol were added to the purified water to dissolve it in warm order, and 120 g of kaolin was added and suspended. Then, 30 g of mugwort extract (based on solids), 0.5 g of diphenhydramine hydrochloride, and an appropriate amount of copper chlorophyll sodium were mixed well.

50 g of sodium polyacrylate was dispersed in 130 g of propylene glycol, warmly dissolved in 90 g of polyvinyl alcohol in a portion of purified water, and 0.3 g of vanyl butyl ether and an appropriate amount of mugwort were dissolved in 30 g of methyl salicylate.

Separately, 1.0 g of paraoxybenzoic acid butyl was heated and dissolved in a part of purified water. The paste was prepared by mixing the salicylic acid methyl solution, the propylene glycol suspension solution, the polyvinyl alcohol solution, and the preservative solution in this order.

The paste was intimately attached to a nonwoven fabric, dried at 60 ° C. for 10 minutes, covered with a polyethylene film, and cut into appropriate sizes to prepare a wormwood patch.

.

Claims (3)

Herbal medicines that can be used in the present invention include wormwood or gardenia, gardenia, mackerel, horse chestnut seed, yukari, peppermint, licorice, ginseng, or the like, or its extracts, etc. As pharmacologically active substances, ketoprofen, ibuprofen, roxofene, flubiprofen, pyroxicam, tenoxycam, auranopine, indomethacin, ketorolac, tenidaf, felbinac, diclofenacdiethylammonium, Etodorak, indomethacinpalnesyl, camphor, salicylic acid salts can be used, and any pharmacologically active substance that can be used can use any pharmacologically active substance known in the prior art without particular limitation. Vanyl butyl ether (Phone, 4- (butoxymethyl) -2-methoxy), benzyl nicotinate, 1,2-propandiol, 3-[[5-methyl-2- (1-methylethyl) cyclohexyl]] Cl3H26O3), tocopherol nicotinate, vigor, garlic, ginger, gardenia patch or other external preparations such as gels, creams, ointments, sprays A patch or other external preparation such as gel, cream, ointment or spray used by adding a self-heating substance to the ingredient composition of claim 1 Claim 2 as a self-heating material zeolite, activated carbon, alumina, silica gel, bentonite, saturated carbon adsorbing carbon monoxide (CO) in the copper chloride compound, clay, tourmaline, resin, silica, shale (clay), limestone, polymer, etc. Patches or gels containing SiO 2, Al 2 O 3, Fe 2 O 3, MgO, CaO, Na 2 O, K 2 O, Alite, Belite, Aluminate, Ferrite, etc., which may contain or be exemplified as components of the self-heating substance Other external preparations such as creams, ointments and sprays