KR20030084135A - Inhibition Tools for Streptococcus mutans - Google Patents
Inhibition Tools for Streptococcus mutans Download PDFInfo
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- KR20030084135A KR20030084135A KR1020020022657A KR20020022657A KR20030084135A KR 20030084135 A KR20030084135 A KR 20030084135A KR 1020020022657 A KR1020020022657 A KR 1020020022657A KR 20020022657 A KR20020022657 A KR 20020022657A KR 20030084135 A KR20030084135 A KR 20030084135A
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- 241000194019 Streptococcus mutans Species 0.000 title abstract description 3
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000000956 alloy Substances 0.000 claims abstract description 16
- 229910045601 alloy Inorganic materials 0.000 claims abstract description 16
- 229910052751 metal Inorganic materials 0.000 claims abstract description 16
- 239000002184 metal Substances 0.000 claims abstract description 16
- 241000894006 Bacteria Species 0.000 claims abstract description 10
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 6
- 239000011777 magnesium Substances 0.000 claims abstract description 6
- 150000002739 metals Chemical class 0.000 claims abstract description 6
- 229910052702 rhenium Inorganic materials 0.000 claims abstract description 6
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000004140 cleaning Methods 0.000 claims abstract description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000007772 electrode material Substances 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 239000011344 liquid material Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 210000000214 mouth Anatomy 0.000 abstract description 11
- 208000002925 dental caries Diseases 0.000 abstract description 7
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract description 4
- 229910052802 copper Inorganic materials 0.000 abstract description 4
- 239000010949 copper Substances 0.000 abstract description 4
- 238000005260 corrosion Methods 0.000 abstract description 4
- 230000007797 corrosion Effects 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 239000000919 ceramic Substances 0.000 abstract description 3
- 238000010276 construction Methods 0.000 abstract description 3
- 239000010977 jade Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract description 2
- 239000002131 composite material Substances 0.000 abstract description 2
- 231100000676 disease causative agent Toxicity 0.000 abstract description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract description 2
- 229910052737 gold Inorganic materials 0.000 abstract description 2
- 239000010931 gold Substances 0.000 abstract description 2
- 229910052709 silver Inorganic materials 0.000 abstract description 2
- 239000004332 silver Substances 0.000 abstract description 2
- 230000009897 systematic effect Effects 0.000 abstract description 2
- 238000012795 verification Methods 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 description 4
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000010970 precious metal Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000003749 cleanliness Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B15/00—Other brushes; Brushes with additional arrangements
- A46B15/0002—Arrangements for enhancing monitoring or controlling the brushing process
- A46B15/0016—Arrangements for enhancing monitoring or controlling the brushing process with enhancing means
- A46B15/0022—Arrangements for enhancing monitoring or controlling the brushing process with enhancing means with an electrical means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
- C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
- C02F1/467—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection; by electrooxydation or by electroreduction
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Environmental & Geological Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Water Supply & Treatment (AREA)
- Organic Chemistry (AREA)
- Hydrology & Water Resources (AREA)
- Electrochemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dentistry (AREA)
- Epidemiology (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
본 발명은 구강 내에 존재하는 충치 원인 균으로 알려진 뮤탄스 구균(Streptococcus mutans)의 치아 부착을 억제하는 효과를 가지는 장치의 구성에 관한 것으로서, 기술적으로는 금속의 표준 전위차에 의한 부식반응의 원리를 응용하는 것이다. 이미 항균 작용을 하는 장치들로서 천연 옥이나 세라믹 등의 소재를 혼합하여 만든 복합소재에 의해 구체화되지 않은 여러 세균들을 살균할 수 있다는 장치들이 나와 있으나, 그 효과의 체계적인 입증은 어려운 상태이다. 본 발명에서는 음극으로서 작용하는 금속으로 마그네슘과 일정 함량의 알루미늄, 레늄으로 구성된 합금을 이용하여 표준 전지를 구성하게 되면 부식반응이 진행되는 원리에 의해 구강 내에 잔존하는 뮤탄스 구균의 수가 크게 감소하게 됨을 확인하였다. 이때 양극으로서 작용하는 금속으로서는 금과 은, 동 등의 범용 금속이 모두 효과가 있으나, 그 정도에 있어 차이가 있다 하겠다. 본 발명에서 고안된 장치들을 실시함에 있어서는 여러 형태의 장치가 가능하여 칫솔 등의 구강 세정 장치는 물론이고, 구형 또는 다른 형태의 소형 장치를 구성하여 수분동안 구강 내에 정치하면 뮤탄스 구균의 감소에 따라 치아의 충치 예방 효과가 있을 것이다.The present invention relates to the construction of a device having an effect of inhibiting tooth adhesion of Streptococcus mutans , known as the causative agent of caries present in the oral cavity, and technically applying the principle of corrosion reaction by standard potential difference of metals. It is. Already, there are devices that can kill various bacteria that are not embodied by composite materials made by mixing materials such as natural jade or ceramic as antibacterial devices, but the systematic verification of the effect is difficult. In the present invention, when a standard battery is formed by using an alloy composed of magnesium, a predetermined amount of aluminum and rhenium as a metal serving as a cathode, the number of mutans cocci remaining in the oral cavity is greatly reduced due to the principle of corrosion reaction. Confirmed. At this time, as a metal acting as an anode, all of general-purpose metals such as gold, silver, and copper are effective, but there are differences in the degree thereof. In implementing the devices devised in the present invention, various types of devices are possible, so as to form an oral cleaning device such as a toothbrush, and a small or spherical device of a spherical shape or another type, and standing in the oral cavity for a few minutes to reduce the amount of mutans cocci. Will be effective in preventing caries.
Description
종래부터 일상생활에서 발생하는 각종 세균에 의한 질병을 방지하기 위한 노력들이 있어 왔으며, 최근에는 보다 구체화 된 제품들이 출시되고 있다. 천연 옥이나 세라믹 분말 등을 상품 제조 단계에서 혼합하여 신비스러운 작용에 의해 청결이 유지된다거나, 원적외선의 효과에 의해 살균이 유지된다는 등의 주장이 있어 왔다. 또한 전통적으로 귀금속류들이 살균효과가 있다는 믿음으로 칫솔의 헤드 부위에 여러 가지 방법에 의해 귀금속의 조각을 식재하면 살균효과가 있다는 주장도 있다(공개번호 특1999-007559). 그러나 이러한 주장은 그 살균 효과가 체계적이고도 정량, 정성적인 입증이 어려울 뿐만 아니라, 각종 세균에 대해 나타나는 효과의 정도가 상이함에도 그 대상을 구체적으로 특정하지 않는 오류를 내포하고 있다.Conventionally, efforts have been made to prevent diseases caused by various bacteria occurring in daily life, and more recently, more specific products have been released. There have been claims that natural jade, ceramic powder, and the like are mixed in a product manufacturing step to maintain cleanliness by a mysterious action, or sterilization is maintained by the effect of far infrared rays. There is also a belief that traditionally, precious metals have a bactericidal effect, and that planting pieces of the precious metal by various methods on the head of the toothbrush has a bactericidal effect (see Publication No. 1999-007559). However, this claim is not only difficult to systematically quantitatively and qualitatively prove the bactericidal effect, but also includes an error that does not specifically specify the object even though the degree of effect on various bacteria is different.
본 발명은 위의 장치들과 달리 음극으로서 사용되는 금속의 특별한 조성에의해 이루어진 합금이 여러 세균들에 대한 살균효과가 있음은 물론이고, 특히 구강내의 충치 원인 균인 뮤탄스 구균에 대한 치아 부착 억제 효과가 뛰어남을 알아 내어 본 발명을 완성하였다.The present invention, unlike the above devices, the alloy made by a special composition of the metal used as the negative electrode has a bactericidal effect against a variety of bacteria, as well as the effect of inhibiting tooth adhesion to mutans cocci, in particular the cause of caries in the mouth Was found to complete the present invention.
본 발명은 위에서 기술한 바와 같이 여러 살균효과를 주장하는 장치들이 구체적으로 특정되지 않고 있으나, 마그네슘과 알루미늄, 레늄으로 구성된 특별한 음극 역할 금속에 의해 구강 내의 충치 원인 균인 뮤탄스 구균의 치아 부착 억제 효과가 뛰어난 장치 및 그 구성 방법을 제공하고자 한다.The present invention is not specifically specified devices that claim various sterilization effects as described above, but by the special cathode role metal composed of magnesium, aluminum, rhenium, the effect of inhibiting tooth adhesion of mutans cocci, the cause of tooth decay in the oral cavity, An excellent device and a method of constructing the same are provided.
도 1은 주요 3성분 합금의 X-선 회절 곡선을 나타낸 그림이다.1 is a diagram showing the X-ray diffraction curve of the main three-component alloy.
도 2는 주요 3성분 합금과 동으로 구성된 전극의 접촉 시간에 따른 타액 속의 뮤탄스 구균 감소를 보여주는 그림이다.2 is a diagram showing the reduction of mutans cocci in saliva with the contact time of the electrode consisting of the main three-component alloy and copper.
상기의 목적을 달성하기 위하여 본 발명의 구성 및 작용에 대하여 구체적으로 명확하게 기술하며, 마그네슘과 알루미늄, 레늄으로 구성된 특별한 음극 금속의 역할 및 바람직한 실시 예를 제공한다.The construction and operation of the present invention are specifically described in order to achieve the above object, and provide a role and a preferred embodiment of a special cathode metal composed of magnesium, aluminum, and rhenium.
본 발명은 구강 내에 존재하는 충치 원인 균으로 알려진 뮤탄스 구균(Streptococcus mutans)의 치아 부착을 억제하는 효과를 가지는 장치의 구성에 관한 것으로, 금속의 표준 전위차에 의한 부식반응의 원리를 응용하는 것이다. 이미 항균 작용을 하는 장치들이 다양하게 제작되고, 여러 분야에서 이용되고 있으나, 대개는 천연 옥이나 세라믹 등의 소재를 혼합하여 만든 복합소재에 의한 것으로서 그 효과의 현상과 대상이 구체화되지 않은 단점을 가지고 있으며, 더욱이 그 효과의 체계적이고도 정량적인 입증은 어려운 상태이다. 그러나 본 발명에서는 음극으로서 작용하는 금속이 특별히 고안되었으며, 이는 일정 함량비의 마그네슘과알루미늄, 레늄으로 이루어진 합금인 것으로, 도 1과 같이 X-선 회절 분석 데이터에서 주요 3성분의 음극 합금이 형성된 것을 확인 할 수 있다. 이를 이용하여 표준 전지를 구성하게 되면 부식반응이 진행되는 원리에 의해 생활 세균들의 감소 효과 있으며, 특히 구강 내에 잔존하는 뮤탄스 구균의 수가 크게 감소하게 됨을 확인하였다.The present invention relates to the construction of a device having an effect of inhibiting tooth adhesion of Streptococcus mutans , known as the causative agent of caries present in the oral cavity, and to the application of the principle of corrosion reaction by standard potential difference of metal. Already, anti-bacterial devices have been manufactured in various ways and used in various fields, but most of them are composite materials made by mixing materials such as natural jade or ceramics. Moreover, the systematic and quantitative demonstration of the effect is difficult. However, in the present invention, a metal that functions as a negative electrode has been specially designed, which is an alloy composed of magnesium, aluminum, and rhenium in a certain content ratio. As shown in FIG. 1, a main three-component negative electrode alloy is formed in the X-ray diffraction analysis data. You can check. It was confirmed that when the standard battery was constructed using this, the corrosion reaction proceeded to reduce the living bacteria, and in particular, the number of mutans cocci remaining in the oral cavity was greatly reduced.
세균의 감소 효과를 위한 일정 전위차를 얻을 수 있기 위해 전극을 구성하는 방법은 다양할 수 있겠으며, 양극으로서 작용하는 금속으로서는 금과 은, 동 등의 범용 금속이 모두 효과가 있다. 그러나 전위차의 정도에 있어서는 많은 차이가 있다 하겠다. 따라서 양극의 물질에도 불구하고 위의 3성분 합금에 의해 그 효과가 나타난다는 점이 본 발명의 특징이라 하겠다. 또한 본 발명에서 고안된 장치들을 실시함에 있어서는 여러 형태의 장치가 가능하여 칫솔 등의 구강 세정 장치는 물론이고, 구형 또는 다른 형태의 소형 장치를 구성하여 수분동안 구강 내에 정치하면 뮤탄스 구균의 감소에 따라 치아의 충치 예방 효과가 있을 것이다In order to obtain a constant potential difference for reducing the bacteria, the electrode may be configured in various ways. As the metal serving as the anode, general metals such as gold, silver, and copper are effective. However, there are many differences in the degree of potential difference. Therefore, it is a feature of the present invention that the effect appears by the above three-component alloy despite the material of the positive electrode. In addition, in the implementation of the devices designed in the present invention, various types of devices are possible, as well as oral cleaning devices such as toothbrushes, and spherical or other types of small devices, which are left in the oral cavity for a few minutes, according to the reduction of mutans cocci. It will help prevent tooth decay
이하의 실시예들은 본 발명을 예증하기 위한 것으로서 본 발명의 범위를 국한시키는 것으로 이해되어져서는 안 된다.The following examples are intended to illustrate the invention and should not be understood as limiting the scope of the invention.
실시예 1Example 1
본 발명에 의해 고안된 주요 3성분 합금을 음극으로 하고, 범용의 동을 양극으로 하여 전극을 구성한 예로 설명하였다.As an example, the main tricomponent alloy devised by the present invention is used as the cathode, and the general purpose copper is used as the anode.
먼저 두 금속을 일정 거리를 유지하도록 보통의 칫솔에 장착한 후 준비된 타액 속의 뮤탄스 구균의 수를 측정하였다. 타액은 파라핀 자극에 의해 얻어 예비처리 후 배양하여 사용하였다. 도 2는 타액 속의 뮤탄스 구균이 본 발명에 의해 고안된 전극과의 접촉에 의해 감소됨을 보여주는 실험 결과이며, 분안에 약 %의 뮤탄스 구균이 감소되었음을 알 수 있다.First, the two metals were mounted on a common toothbrush to maintain a certain distance, and then the number of mutans cocci in the prepared saliva was measured. Saliva was obtained by paraffin stimulation and cultured after pretreatment. 2 is an experimental result showing that mutans cocci in saliva is reduced by contact with an electrode devised by the present invention, and it can be seen that about% mutans cocci were reduced in minutes.
실시예 2Example 2
위와 유사한 효과를 얻기 위해, 본 발명에 의해 고안된 주요 3성분 합금과 범용의 양극 역할 금속을 설치한 장치를 구성하는 예로서, 구강내에 직접 삽입하여 일정시간 동안 유지시키는 장치가 구성 될 수 있다. 이들의 형태는 구형이 무난하겠으나, 여타의 형태도 가능할 것이며, 구강내에 정치될 수 있을 만큼 그 크기가 작으면 사용하기에 더욱 용이할 것이다. 여기에서 본 발명에 의해 고안된 주요 3성분 합금이 음극으로서의 작용을 하는 것이 특징이라 할 수 있다.In order to obtain a similar effect to the above, as an example of configuring a device installed with the main three-component alloy and the general purpose role metal devised by the present invention, the device can be configured to be inserted directly into the oral cavity for a certain time. These forms may be spherical, but other forms may be possible, and may be easier to use if they are small enough to be left in the oral cavity. Here, it can be said that the main three-component alloy devised by the present invention functions as a cathode.
실시예 3Example 3
위와 유사한 효과를 얻기 위해 고안된 장치들이 여타의 목적으로 응용될 수 있다. 이때에는 두 전극을 유지시키기 위한 매질을 필요로 할 것이며, 보통의 액체이면 무난 할 것이다. 그 예로 정수기의 필터에 본 발명에 의해 고안된 주요 3성분 합금과 여타의 양극 금속으로 전극을 구성하면 음용수 내의 세균 감소 효과를 나타내는 효율 좋은 장치를 구성할 수 있다.Devices designed to achieve a similar effect to the above can be applied for other purposes. This will require a medium to hold the two electrodes, and a normal liquid would be acceptable. For example, if the electrode is composed of the main three-component alloy and other anode metals devised by the present invention in the filter of the water purifier, it is possible to construct an efficient device exhibiting the effect of reducing bacteria in drinking water.
본 발명에 의해 고안된 주요 3성분 합금과 양극을 형성하는 범용 금속에 의해 구강내 치아에 부착되는 뮤탄스 구균이 크게 감소하는 효과를 나타내게 되어, 이를 이용한 장치에 의해 치아의 충치 발생율을 크게 줄일 수 있으며, 여타의 세균에 대해서도 그 효과가 나타나므로 구강을 통해 발생되는 질병의 발생을 크게 줄일 수 있다. 뿐만 아니라 크기와 형태를 자유롭게 얻을 수 있으므로 많은 분야에 다양하게 응용이 가능하다. 바람직하게는 액상의 매질에 의해 전파되는 세균들을 크게 줄일 수 있는 장치들 즉, 음용수 처리를 위해 정수기에 부착할 수 있는 장치, 식품의 운반이나 보관시 위생적으로 저장 안정성을 높일 수 있는 장치들을 고안하는데 많은 응용이 있을 것이다.The mutans cocci attached to the oral teeth by the main three-component alloy devised by the present invention and the general-purpose metal forming the anode can be greatly reduced, and the incidence of tooth decay can be greatly reduced by the device using the same. In addition, the effect is shown to other bacteria can greatly reduce the occurrence of diseases occurring through the oral cavity. In addition, since the size and shape can be freely obtained, various applications are possible. Preferably, to devise a device that can greatly reduce the bacteria propagated by the liquid medium, that is, a device that can be attached to the water purifier for treatment of drinking water, a device that can increase the hygienic storage stability when transporting or storing food. There will be many applications.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4027393A (en) * | 1975-09-19 | 1977-06-07 | Sybron Corporation | Method of in vivo sterilization of surgical implantables |
| US4126937A (en) * | 1977-03-23 | 1978-11-28 | Sybron Corporation | Material and method for introducing ionic silver to dental pulp |
| KR20010022825A (en) * | 1997-08-14 | 2001-03-26 | 페리오딘틱스, 인크. | Use of locally delivered metal ions for treatment of periodontal disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4027393A (en) * | 1975-09-19 | 1977-06-07 | Sybron Corporation | Method of in vivo sterilization of surgical implantables |
| US4126937A (en) * | 1977-03-23 | 1978-11-28 | Sybron Corporation | Material and method for introducing ionic silver to dental pulp |
| KR20010022825A (en) * | 1997-08-14 | 2001-03-26 | 페리오딘틱스, 인크. | Use of locally delivered metal ions for treatment of periodontal disease |
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