KR20030059953A - Fungicide and insecticide composition for house dust-mite control - Google Patents

Abstract

PURPOSE: A composition of the agent for controlling house dust mites is provided which contains o-phenylphenol, together with a pyrethroid insecticide. The agent is safe to the human body and has excellent bactericidal and insecticidal effects. CONSTITUTION: A composition of the bactericidal and insecticidal agent for controlling house dust mites contains 0.1 to 30% by weight of o-phenylphenol, a pyrethroid insecticide and a solvent. The solvent is water or ethanol. The formulation type of the composition is aerosol. The mites having a size of 0.1 to 0.5mm are selected from Dermatophagoides farinae, Dermatophagoides pteronyssinus, Tyrophagus putrescentiae or the like. The pyrethroid insecticide is selected from the group consisting of allethrin, d-cis/trans allethrin, d-trans allethrin, bioallethrin, d,d-cis/trans prallethrin, permethrin, resmethrin, d-resmethrin, phthalthrin and d-phenothrin.

Description

Fungicidal and insecticide compositions for combating dust mites {FUNGICIDE AND INSECTICIDE COMPOSITION FOR HOUSE DUST-MITE CONTROL}

The present invention relates to a sterilization and insecticide composition for combating dust mites, and more particularly safe to the human body, having a dust dust insect pesticidal effect, and a fungicidal effect against fungi and bacteria, in particular o-phenylphenol pyrethroid The present invention relates to a sterilizing and insecticide composition for combating house dust mites, in which ο-phenylphenol acts as an insecticide cooperative agent to add insecticidal function to house dust mites.

Dust mites, fungi, and bacteria have recently become a major cause of pediatric asthma, dermatitis and allergic diseases in general residential areas.

House dust mites are 0.1 to 0.5 mm in size and easily dispersed in the air, so they can easily be polluted anywhere in the house. In addition, human skin, cuticles, and dandruff are good foods for house dust mites, so bedding, beds, sofas, carpets, etc., are ideal places for environmental conditions such as temperature and humidity. It becomes a hotbed.

The main species of house dust mites in residential spaces are Dermatophagoides farinae , Dermatophagoides pteronyssinus , and Tyrophagus putrescentiae . Allergens caused by house dust mites are not directly caused by house dust mites, but the excretion of house dust mites and decomposed products of dead individuals.

In order to reduce allergic diseases by separating house dust mites from allergens, first of all, house dust mites such as house dust can be reduced in food and house dust mite-related covers are put on the bedding or bed to block the inhalation of house dust mite-related substances. There is a way. However, the former method can reduce allergic diseases to some extent, but cannot be a fundamental solution, and the latter method has a problem of high price and many inconveniences.

House dust mite is a major pest of allergic causes that are positive in more than 80-90% of patients suffering from allergic diseases, there is no fundamental preventive measures yet. In addition, mold and bacteria are less serious than house dust mites, but are causing various diseases including allergic diseases in the same living space as house dust mites.

Allergic diseases caused by fungi and bacteria are mostly respiratory diseases, of which fungi are more problematic, which form allergens and spores as contaminants. Spores consist of one to three cells that float easily in the air and contaminate every corner of the house, like house dust mites, and isolate and identify contaminants, such as beds, sofas, and carpets, as a result of Cladosporium , Alterna Liao (Alternaria), the contaminants, such as Aspergillus (Aspergillus), Penny room Solarium (Penicillium) was isolated as the main mold.

Fungi can normally exist throughout the year in residential areas, and during nutrient growth with hyphae, when the environment worsens, they form spores as part of the reproductive growth, which often begins in spring, most often in July. Lose.

Usually fungi and bacteria can directly cause allergic diseases, but they live in the same place as house dust mites, which are the main cause of allergic diseases, and can be used to feed the house dust mites, which can help the house dust mite grow quickly. Big.

There are many ways to isolate allergens, which are the causes of allergic diseases, from the human body, but it is difficult to keep the bed mattresses, carpets, sofas, etc. in hot water over 60 ℃ to keep them clean from time to time. Expensive house dust mite prevention cover should be used for sofas, and house dust mites such as carpets, fabrics, curtains, stuffed animals, carpets, and the like must be removed from materials that can propagate.

Currently, some household pesticides and fungicides are used in various formulations to remove allergens such as house dust mites, molds and bacteria. Among them, aerosol formulations are used the most.

Conventional pesticides of household aerosol insecticides used in the past used organophosphorus insecticides such as dichlobos (DDVP), but nowadays it is a similar synthetic component of pyrethrin, a pesticide component of insect pests, which is a human safety pyrethroid insecticide Is mainly used.

In addition, disinfectants commonly used in household disinfection products include methylisothiazolinone, imidazolidinyl urea, 2,4,4-trichloro-2-hydroxy diphenyl ether (2,4). , 4-trichloro-2-hydroxy diphenylether, thiabendazole, DMDM hydantoin, and the like, ο-phenylphenol.

Insecticides and fungicides, which are usually used for home use, are also important for prescription pesticides and bactericidal effects, but human safety is also very important when directly inhaling or inhaling the human body.

Therefore, there is a need for further research on fungicides and insecticides that are safe for the human body and have excellent insecticidal effects on house dust mites, and fungi and fungi.

In order to solve the above problems, an object of the present invention is to provide an excellent human safety, house dust mite insecticidal effect, and excellent disinfection effect against mold, bacteria, house dust mite sterilization, and pesticide composition.

Another object of the present invention is to provide a sterilizing and insecticide composition for house dust mite eradication that can be added to the insecticide function of ο-phenylphenol acts as an insecticide cooperative agent when o-phenylphenol is mixed with a pyrethroid insecticide will be.

Figure 1 is a graph showing the insecticidal properties over time for the house dust mite of the sterilizing and insecticide composition prepared in the embodiment of the present invention.

In order to achieve the above object, the present invention

a) ο-phenylphenol;

b) pyrethroid insecticides; And

c) solvent

It provides a house dust mite eradication and insecticide composition for combating.

Hereinafter, the present invention will be described in detail.

The inventors of the present invention studied a pesticide and fungicide composition that is not only safe for the human body but also has excellent insecticidal effect on house dust mites. As a result of using a mixture of ο-phenylphenol and a pyrethroid-based insecticide, ο-phenylphenol is an insecticide cooperative (synergist) has been confirmed that can add a pesticidal function for house dust mite, based on this, the present invention was completed.

The bactericidal and insecticidal composition of the present invention simultaneously exhibits the insecticidal effect against house dust mite insecticide by the human safety pyrethroid insecticide and mold and bacteria caused by ο-phenylphenol, especially the ο-phenylphenol which is a bactericidal component. It acts as a pesticidal synergist that increases the insecticidal effect on the insecticide, which can significantly improve the insecticidal effect.

Ο-phenylphenol of the a) used in the present invention is preferably included in an amount of 0.1 to 30% by weight relative to the bactericidal and insecticide composition, and when the content is less than 0.1% by weight, sterilization, and Insecticidal effect is insignificant, and if it exceeds 30% by weight there is a problem that can not expect a proportional improvement effect.

The ο-phenylphenol not only functions to disinfect fungi, bacteria, and remove the house dust mite, but also has its own insecticidal effect on the house dust mite, and adds a sterilization function when used in combination with the pyrethroid insecticide of b). Can be used as an insecticide cooperative agent. In addition, the ο-phenylphenol is excellent in human safety and suitable for use as a home disinfectant (cosmetic raw material standard collection, Jangwongi).

In addition, fungi and bacteria are different in eukaryotic and prokaryotic cell structure, so there is a difference in sterilization mechanism, and there are few fungicides that have a bactericidal effect on eukaryotes and prokaryotes using a single bactericidal component. As shown in Table 1, there is an effect showing the bactericidal effect on the mold and bacteria at the same time.

division ο-phenylphenol concentration (%) 0.001 0.005 0.01 mold Aspergillus niger × × ○ Penicillium sp. × △ ○ Yeast △ ○ ○ Germ Staphylococcus aureus ○ ○ ○ Pseudomonas sp. △ ○ ○ [Note] ○: Excellent, △: Normal, ×: None

The pyrethroid insecticide of b) used in the present invention is preferably included in an amount of 0.1 to 30% by weight based on the bactericidal and insecticide composition, and examples thereof include allerthrin, di-cis / trans allerthrin and di-trans allerin. Trilin, bio alltrin, di, di-cis / trans praletrin, permethrin, resmethrin, di-lesmethrin, phthaltrin, cypermethrin, or di-phenotrine.

The insecticidal mechanism of the house dust mite of the pyrethroid insecticide is a shock company through the over-excitation of the nervous system by inhibiting the acetylcholinesterase action of the same nervous system as that of the common insect.

The solvent of c) includes the residual amount, and may be used alone or in combination with water or ethanol. In the present invention, ethanol was applied to be easily applied to house dust mites, which are causes of allergic diseases, and molds, bacteria, and the like, sofas, beds, and carpets.

The bactericidal, and insecticide compositions of the present invention can be prepared and used in any formulation, such as aerosols, liquids, gels, powders, solids, pellets, and are preferably aerosol formulations. Nematicides of the aerosol formulations are prepared by conventional methods. In addition, the bactericidal and pesticide compositions may further include solvents, surfactants, emulsifiers, swelling and flow-enhancing agents, aqueous emulsions, or surfactants known in the art.

The sterilization of the aerosol formulation, and the pesticide composition contains 70 to 30% by weight of the sterilization and insecticide composition of the present invention, and 30 to 70% by weight of the propellant. The problem is that it remains. As the propellant, liquefied natural gas, dimethyl ester, compressed air, compressed nitrogen, or the like may be used.

Hereinafter, preferred examples are provided to help understanding of the present invention, but the following examples are merely to illustrate the present invention, and the scope of the present invention is not limited to the following examples.

EXAMPLE

Example

An aerosol solution for combating dust mites was prepared by dissolving 0.11% by weight of di-phenotrine, 0.624% by weight of phthaline, and 0.15% by weight of? -Phenylphenol as a pyrethroid insecticide. An aerosol was prepared by mixing the aerosol stock solution and the propellant in a volume ratio of 60:40 by using natural liquefied petroleum gas as the propellant.

Comparative Example 1

An aerosol stock solution for combating house dust mites was prepared by dissolving 0.11% by weight of di-phenotrine and 0.624% by weight of phthaline as a pyrethroid insecticide in a solvent of ethanol. An aerosol was prepared by mixing the aerosol stock solution and the propellant in a volume ratio of 60:40 by using natural liquefied petroleum gas as the propellant.

Comparative Example 2

0.15% by weight of? -phenylphenol was dissolved in ethanol as a solvent to prepare an aerosol stock solution for combating dust mites. An aerosol was prepared by mixing the aerosol stock solution and the propellant in a volume ratio of 60:40 by using natural liquefied petroleum gas as the propellant.

Comparative Example 3

An aerosol was prepared by mixing an aerosol stock solution and a propellant in a volume ratio of 60:40, using only ethanol as a stock solution without using a dust mite extinguishing agent.

Experimental Example 1

Immediately before the experiment was sprayed in a beaker in advance to receive the aerosol stock solution prepared in Examples and Comparative Examples 1 to 3, and then laid a cotton fabric on the bottom of 5 cm Shaale, breeding at 25 ℃ breeding temperature and 80% relative humidity About 20 to 30 grains of mite ( Dermatophagoides pteronyssinus ) were thinly sliced on cotton fabric. Thereafter, 50 µl of the stock solution was dropped using a micro pipette, and the stock solution was spread evenly over the cotton cloth laid on the bottom, and the reaction of house dust mites over time was observed. At this time, the 5 cm Shaale dropping the stock solution was immediately transferred to the stereoscopic microscope to observe the reaction, the results are shown in Table 2, and FIG.

division 0 min 1 minute 2 mins 4 mins 8 mins 12 mins 20 minutes Example 0 5 14 38 67 92 100 Comparative Example 1 0 0 7 25 54 80 94 Comparative Example 2 0 0 0 7 7 12 12 Comparative Example 3 0 0 0 0 3 3 3

Table 2, and Figure 1, Comparative Example 1, ο aerosol of the embodiment containing both a pyrethroid-based insecticide and ο-phenylphenol of the present invention includes a pyrethroid-based insecticide having an insecticidal effect on house dust mites As compared with the aerosol of Comparative Example 2 containing only phenylphenol, and Comparative Example 3 containing no pesticidal component, it was confirmed to exhibit excellent insecticidal effect.

Comparative Example 4

Except for using the kerosene, a conventional aerosol solvent in place of ethanol as a solvent in the above embodiment was carried out in the same manner as in the above embodiment.

Experimental Example 2

Dissatisfaction with the aerosol using the kerosene solvent of Comparative Example 4 as a result of using the aerosol sample prepared in Example and Comparative Example 4 for 40 people, and using the kerosene solvent of Comparative Example 4 to evaluate satisfaction Satisfaction with respect to the aerosol of the embodiment using the ethanol solvent according to the present invention was excellent as 4.2).

As described above, the house dust mite sterilization and insecticide composition of the present invention is safe to the human body, and has a house dust mite insecticidal effect, and a fungicidal effect against mold, bacteria, in particular o-phenylphenol pyrethroid When used in combination with insecticides, ο-phenylphenol acts as an insecticide co-agent, which has the advantage of adding insecticidal function against house dust mites. In addition, it is effective in removing house dust mites, which are a major cause of allergic diseases, in modern residential living spaces, where the spread of sofas, carpets, beds, etc. is gradually increased due to the convenience of living.

Claims (5)

a) ο-phenylphenol; b) pyrethroid insecticides; And c) solvent House dust mites eradication and insecticide composition for combating. The method of claim 1, Sterilization and insecticide composition for combating house dust mite, wherein the ο-phenylphenol of a) is contained in an amount of 0.1 to 30% by weight based on the bactericidal and insecticide composition. The method of claim 1, The pyrethroid insecticides of b) are allerthrin, di-cis / trans allerthrin, di-trans allerthrin, bio allerthrin, di, di-cis / trans praletrin, permethrin, resmethrin, di-res A bactericidal and insecticide composition for combating house dust mites selected from the group consisting of metrin, phthaltrin, cypermethrin, and di-phenotrine. The method of claim 1, Sterilizing and insecticide composition for combating house dust mite, wherein the solvent of c) is water or ethanol. The method of claim 1, The bactericidal and insecticide composition for combating house dust mite, wherein the bactericidal and insecticide composition is an aerosol formulation.