KR20020067038A - Personal care articles comprising anionic polymer coacervate compositions - Google Patents

Abstract

The present invention relates to a substantially dry disposable personal care article comprising:

a) a water insoluble substrate comprising a nonwoven layer; And

b) a therapeutically potent member disposed adjacent to the water-insoluble substrate, wherein the therapeutically potent member comprises, from a water insoluble substrate, from about 10% to about 1000% by weight of a therapeutically effective composition comprising:

1) a safe effective amount of anionic polymer;

2) a safe effective amount of cationic surfactant

Wherein the composition forms coacervate when the article is exposed to water. These articles have been found to be particularly useful for personal cleansing applications, that is to say for the skin and hair. Accordingly, the present invention also relates to methods of cleansing and / or therapeutic treatments (eg, conditioning) of skin and hair with the articles of the invention.

Description

Personal care article containing anionic polymer coacervate composition {PERSONAL CARE ARTICLES COMPRISING ANIONIC POLYMER COACERVATE COMPOSITIONS}

Personal care products, especially cleansing and conditioning products, have conventionally been marketed in various forms such as bar soaps, creams, lotions, and gels. Typically, these products have been tried to satisfy many criteria that are acceptable to consumers. Such criteria include cleansing effects, skin feel, gentleness to the skin, hair and eye mucosa, and foam volume. An ideal personal cleanser should gently cleanse the skin or hair, cause little or no irritation, and leave no heavy detergent deposits on the skin or hair during frequent use or excessively dry the skin or hair.

It is also highly desirable to obtain such cleansing and conditioning efficacy in disposable products. Disposable products are convenient because they do not need to be carried or stored in cumbersome bottles, rods, tubs, tubes and other forms of clutter, including cleansing products and other products that can provide therapeutic or cosmetic benefits. In addition, sponges, washcloths, or widely reused cleansing tools may exhibit undesirable characteristics due to bacterial propagation, unpleasant odors, and other repeated use, and thus are disposable products compared to the use of such tools. This is more hygienic.

The articles of the present invention surprisingly provide cleansing and / or therapeutic efficacy effective to the skin and hair in a simple, inexpensive and hygienic manner. The present invention provides the simplicity of having to carry, store, or use separate tools (such as washcloths or sponges), cleansers and / or therapeutic efficacy products. Such articles are simple to use because they are in the form of single-use disposable personal care articles or multiple disposable articles useful for cleansing as well as application of therapeutic or cosmetic agonists. In addition, the articles are suitable for use in or with another personal care tool designed for wider use. In this case, the article of the present invention is disposed in or attached to a separate personal care tool, such as a bath towel or washcloth, which is not disposable. In addition, the disposable article of the present invention may be detachably attached to a handle or grip suitable for moving on the surface to be cleansed and / or therapeutically treated (eg, conditioned).

In a preferred embodiment the articles of the invention are suitable for personal care applications, but are car care, marine vessel care, furniture which are surfaces or areas which require cleansing and / or application of agonists such as, for example, waxes, conditioners, UV protectants, etc. It may also be useful in various other industries such as care, animal care, and the like.

In a preferred embodiment of the invention, the article is suitable for personal care applications and is useful for cleansing and / or conditioning skin, hair and similar keratinous surfaces requiring such treatment. Consumers use the article by moistening these articles with water and rubbing them into the area to be treated. The article consists of a water insoluble substrate and a lack of therapeutic efficacy. Without being bound by theory, it is believed that the nonwoven layer of the substrate, in particular, enhances cleansing and peeling and optimizes the delivery and deposition of therapeutic or cosmetic agonists that may be contained in the article.

Summary of the Invention

The present invention relates to a substantially dry disposable personal care article, comprising:

a) a water insoluble substrate comprising a nonwoven layer; And

b) a therapeutically potent member disposed adjacent to the water-insoluble substrate, wherein the therapeutically potent member contains from about 10% to about 1000% by weight of the therapeutically potent composition containing, relative to the water-insoluble substrate:

1) a safe effective amount of anionic polymer;

2) a safe effective amount of cationic surfactant;

Wherein the composition forms coacervate when the article is exposed to water.

The invention also relates to a method for cleansing and / or conditioning the skin and hair, comprising a) wetting the article with water and b) contacting the skin or hair with the wetted article.

All percentages and ratios used herein are by weight unless otherwise indicated, and all measurements are made at 25 ° C., unless otherwise specified. The present invention may contain, consist of, or consist essentially of the essential and optional ingredients and members described herein.

In the description of the invention, various embodiments and / or individual features are disclosed. As will be apparent to the skilled practitioner, all combinations of the above embodiments and features are possible and can achieve a preferred implementation of the invention.

All documents referenced herein, including patents, patent applications, and published publications, are incorporated herein by reference in their entirety.

The present invention relates to disposable personal care articles suitable for cleansing and / or therapeutic treatments of skin, hair, and any other areas requiring cleansing and / or therapeutic treatments. The article comprises a water insoluble substrate comprising a nonwoven layer, and a therapeutically effective member disposed adjacent to the water insoluble substrate, wherein the member is a safe effective amount of anionic polymer and a safe effective amount of A therapeutically effective composition containing a cationic surfactant is contained at from about 10% to about 1000% by weight relative to the water insoluble substrate, which composition forms coacervate when the article is exposed to water.

Consumers use the article by moistening the article with water and rubbing it to the area to be cleansed and / or therapeutically treated (eg, conditioned).

The invention also includes a method of cleansing and / or conditioning the skin and hair using the article of the invention.

As used herein, the term "disposable" means, in a general sense, an article that is disposed of or disposed of after a limited number of uses, preferably less than 25, more preferably less than about 10, and most preferably less than about 2 total uses. It is used to mean.

As used herein, the phrase "substantially dry" indicates that the article of the invention is less than about 0.95 gms, preferably less than about 0.75 gms, more preferably less than about 0.5 gms, even more preferably less than about 0.25 gms, more More preferably less than about 0.15 gms, most preferably less than about 0.1 gms. Determination of water retention is discussed later.

The personal care article of the present invention contains the following essential ingredients.

Water Insoluble Substrate

The article of the present invention comprises a water insoluble substrate comprising at least one nonwoven layer or ply. Preferably, this nonwoven layer is non-abrasive. "Non-wear" as used herein means that the layer is described below, wherein the layer is greater than about 15, preferably greater than about 30, more preferably greater than about 50, even more preferably greater than about 70, most preferably greater than about 80 By wear value is meant the wear value measured by the methodology. Preferably, the substrate layer, in use, is soft and pleasant to the consumer skin.

Without being bound by theory, the water-insoluble substrate enhances cleansing and / or therapeutic treatments. The substrate may have the same or different texture on each side such that the grabbing side of the article has the same or different texture as the skin / site contact surface. The substrate can serve as an efficient foaming and peeling tool. By being in physical contact with the skin or hair, the substrate significantly aids in cleansing and removing dirt, makeup, dead skin, and other residues. However, in a preferred embodiment, the substrate is non-abrasive or non-frictional to the skin.

Suitable materials for the nonwoven layer are selected from the group consisting of cellulosic nonwovens, sponges (ie, both natural and synthetic), molded films, batting, and combinations thereof. Preferably, the layer consists of cellulosic nonwovens, molded films, lofty bets, foams, sponges, reticular foams, vacuum formed laminates, scrims, polymeric nets and combinations thereof. It includes a material selected from the group consisting of. More preferably, the nonwoven layer comprises a material selected from the group consisting of cellulosic nonwovens, non-lofty nonwovens, molded films, lofty bets, and combinations thereof. As used herein, "nonwoven" means that the layer does not comprise knitted fibers, but that the layer does not need to contain any fibers, for example molded films, sponges, foams, scrims, and the like. If the layer comprises fibers, the fibers can be carded randomly (ie randomly arranged) or carded (ie, carded orientated primarily in one direction). In addition, the layer may be a composite comprising additional layers, ie combinations of plies, and random, carded fibers.

In one embodiment, the nonwoven layer of the substrate comprises a bet. Preferably, the nonwoven layer is ropey, non-abrasive, and low density. As used herein, a “lofty” has a density of about 0.00005 g / cm ³ to about 0.1 g / cm ³ , preferably about 0.001 g / cm ³ to about 0.09 g / cm ³ , and 5 gms / in ^2. In the range from about 0.04 inches to about 2 inches. The nonwoven layer comprising the batting preferably comprises a synthetic material. As used herein, "synthetic" means that the material is obtained primarily from various artificial materials or additionally modified natural materials. Suitable synthetic materials include acetate fibers, acrylic fibers, cellulose ester fibers, modacryl fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, foamed polyethylene, foamed polyurethanes, and combinations thereof However, it is not limited to this. Preferred synthetic materials, in particular fibers, can be selected from the group consisting of nylon fibers, rayon fibers, polyolefin fibers, polyester fibers, and combinations thereof. Preferred polyolefin fibers are fibers selected from the group consisting of polyethylene, polypropylene, polybutylene, polypentene, and combinations and copolymers thereof. More preferred polyolefin fibers are fibers selected from the group consisting of polyethylene, polypropylene, and combinations and copolymers thereof. Preferred polyester fibers are fibers selected from the group consisting of polyethylene terephthalate, polybutylene terephthalate, polycyclohexylenedimethylene terephthalate, and combinations and copolymers thereof. More preferred polyester fibers are fibers selected from the group consisting of polyethylene terephthalate, polybutylene terephthalate, and combinations and copolymers thereof. Most preferred synthetic fibers contain monochromatic short polyester fibers containing polyethylene terephthalate homopolymers. Suitable synthetic materials include monochromatic monocomponent (ie, chemically homogeneous) fibers, multicomponent fibers (ie, in which more than one type of material constitutes each fiber), and multicomponent fibers (ie, larger fibers intertwined in some way). Synthetic fibers containing at least two distinct filament types), and combinations thereof. Preferred fibers include bicomponent fibers, multicomponent fibers, and combinations thereof. The bicomponent fibers may be in a core-sheath arrangement or side by side arrangement. In each case, the nonwoven layer may contain a combination of fibers containing the materials listed above or a fiber containing a combination of materials listed above.

For core-sheath fibers, preferably, the core contains a material selected from the group consisting of polyesters, polyolefins, and combinations thereof having a Tg of at least about 10 ° C. higher than the sheath material. Conversely, the sheath of the bicomponent fiber is preferably selected from the group consisting of polyolefins having a Tg of at least about 10 ° C. lower than the core material, polyester polyolefins having a Tg of at least about 10 ° C. lower than the core material, and combinations thereof. Contains substance

In any case of a side by side arrangement, a core-sheath arrangement, or a monochromatic single component arrangement, the fibers of the nonwoven layer may exhibit a helical or vortex or corrugated arrangement, in particular bicomponent fibers.

The batting nonwoven layer may also contain natural fibers.

In addition, the fibers of the batting nonwoven layer preferably have an average thickness of about 0.5 microns to about 150 microns. More preferably, the average thickness of the fibers is from about 5 microns to about 75 microns. In even more preferred embodiments, the average thickness of the fibers is from about 8 microns to about 40 microns. In addition, the fibers of the nonwoven layer can have various sizes. That is, the fibers of the nonwoven layer may contain fibers having different average thicknesses. In addition, the cross section of the fibers may be round, flat, oval, oval or otherwise shaped.

In another embodiment, the nonwoven layers of the invention may be joined together in a composite, ie, continuously (eg, lamination, etc.) or in a discontinuous pattern or at the outer edges (or perimeters) of the layers and / or at separate locations. By binding only one may contain a material having one or more plies of the same or different suitable materials that are physically superimposed. For example, the nonwoven layer may further contain a composite selected from the group consisting of fibrous nonwovens, sponges, foams, reticulated foams, polymeric nets, scrims, vacuum formed laminates, molded films and molded film composites. The nonwoven layer preferably contains a molded film composite comprising one or more nonwovens and one or more molded films, the layers of which are vacuum molded. Suitable molded film composites include, but are not limited to, vacuum laminated composite molded film materials formed by combining a molded film and a carded polypropylene nonwoven having a basis weight of 30 gsm.

In another preferred embodiment, the nonwoven layer is voided. The voids in the nonwoven layer of the water insoluble substrate will typically have an average diameter in the range of about 0.5 mm to 5 mm. More preferably, the size of the pores will range from about 1 mm to 4 mm in average diameter. Preferably, up to about 10% of the voids in the nonwoven layer of the substrate will be outside of this size range. More preferably, about 5% or less of the voids in the nonwoven layer will fall outside of this size range. For voids whose shape is not circular, the "diameter" of the voids refers to the diameter of the circular openings having the same surface area as the openings of the non-circular voids.

Within the nonwoven layer, the voids will typically be present at a frequency of about 0.5 to 12 voids per straight centimeter. More preferably, the pores in the surface of the layer will be present at a frequency of about 1.5 to 6 pores per straight centimeter.

The voids should be located at least in the nonwoven layer. The voids need not protrude completely from one surface of the nonwoven layer to the other. However, they may be so. Additionally, the voids may or may not be located in the nonwoven layer of the substrate such that the entire article may be voided through its entire volume.

The voids may be formed in the nonwoven layer of the water insoluble substrate as the water insoluble substrate or layer thereof is formed or fabricated. Alternatively, the voids may be formed in the nonwoven layer after the substrate comprising the layer is fully formed.

The nonwoven layer can contain various natural and synthetic fibers or materials. As used herein, "natural" means that the substance is derived from a plant, animal, insect or by-product of a plant, animal, and insect. Conventional base starting materials are generally fibrous webs containing any of conventional synthetic or natural woven length fibers or combinations thereof.

Non-limiting examples of natural materials useful in the present invention include, but are not limited to, silk fibers, keratin fibers and cellulosic fibers. Non-limiting examples of keratinous fibers include those selected from the group consisting of wool fibers, camel hair fibers and the like. Non-limiting examples of cellulosic fibers include those selected from the group consisting of wood pulp fibers, cotton fibers, hemp fibers, jute fibers, flax fibers and combinations thereof. In the present invention, cellulosic fiber materials are preferred.

Non-limiting examples of synthetic materials useful in the present invention include acetate fibers, acrylic fibers, cellulose ester fibers, modacryl fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, foamed polyethylene, foams Polyurethanes and combinations thereof. Examples of suitable synthetic materials include acrylics such as acryliclan, creslan, and acrylonitrile-based fibers, orlons; Cellulose ester fibers such as cellulose acetate, arnell and aselle; Polyamides such as nylon (eg, nylon 6, nylon 66, nylon 610, etc.); Polyesters such as fortrel, cordel, and polyethylene terephthalate fibers, polybutylene terephthalate fibers, darkons; Polyolefins such as polypropylene, polyethylene; Polyvinyl acetate fibers; Foamed polyurethanes and combinations thereof. These or other suitable fibers and nonwovens made from them are typically described in Riedel, "Nonwoven Bonding Methods and Materials", Nonwoven World (1987); The Encyclopedia Americana , Vol. 11, pp. 147-153, and 26, pp. 566-581 (1984); U.S. Patent 4,891,227 (Thaman et al., Issued January 2, 1990); And US Pat. No. 4,891,228, all of which are incorporated herein by reference in their entirety.

Nonwovens made from natural materials, most commonly, consist of a web or sheet formed on a fine wire screen from a liquid suspension of fibers. CA Hampel et al., The Encyclopedia of Chemistry , 3rd edition, 1973, pp. 793-795 (1973); The Encyclopedia Americana , Vol. 21, pp. 376-383 (1984); And GA Smook, Handbook of Pulp and Paper Technologies , Technical Association for the Pulp and Paper Industry (1986); These are hereby incorporated by reference in their entirety.

Natural material nonwovens useful in the present invention can be obtained from a wide variety of commercial sources. Non-limiting examples of commercially available suitable paper layers useful herein include the following: Airtex (An embossed, airlaid cellulosic layer with a basis weight of about 71 gsy, available from James River, Green Bay, WI); And Walkisoft (Embossed and pneumatic cellulose based, with a basis weight of about 75 gsy, available from Walkisoft USA, Mount Holly, NC.).

Additional suitable nonwoven materials include US Pat. No. 4,447,294 (Osborn, issued May 8, 1984, May 8), each of which is incorporated herein by reference in its entirety; No. 4,603,176 (Bjorkquist, issued July 29, 1986); No. 4,981,557 (Bjorkquist, issued January 1, 1991); 5,085,736 (Bjorkquist, issued February 4, 1992); No. 5,138,002 (Bjorkquist, issued August 8, 1992); No. 5,262,007 (Phan et al., Nov. 16, 1993); No. 5,264,082 (Phan et al., Issued Nov. 23, 1993); No. 4,637,859 to Trokhan, issued January 20, 1987; No. 4,529,480 (Trokhan, issued July 16, 1985); No. 4,687,153 (McNeil, issued Aug. 18, 1987); 5,223,096 (Phan et al., Issued June 29, 1993); And 5,679,222 to Rasch et al., Issued October 21, 1997.

Methods of making nonwovens are well known in the art. Typically, these nonwovens can be produced by air-laying, water laying, melt blowing, coformimg, spunbonding, or carding processes, where the fibers or filaments are first It is cut from long strands to the desired length, passed through a water or air stream, and then fibrously loaded air or water is passed through the screen and deposited on the screen. The resulting layer is then subjected to one or more different types of bonding processes, regardless of the method of manufacture or composition thereof, to fix the individual fibers together to form a self-sustained web. In the present invention, the nonwoven layer can be prepared by a variety of processes, such as, but not limited to, air entanglement, hydroentanglement, thermal bonding, and combinations of these processes.

Nonwovens made from synthetic materials useful in the present invention can be obtained from a wide variety of commercial sources. Non-limiting examples of suitable nonwoven layer materials useful herein include: HEF 40-047 (pore containing about 50% rayon and 50% polyester and having a basis weight of about 61 grams per square meter (gsm) Wet tangled material formed, available from Veratec, Inc., Walpole, MA; HEF 140-102 (a pore formed wet entangled material containing about 50% rayon and 50% polyester and having a basis weight of about 67 gsm, available from Veratec, Inc., Walpole, MA); Novonet149-616 (a thermally bonded lattice pattern material containing about 100% polypropylene and having a basis weight of about 60 gsm, available from Veratec, Inc., Walpole, MA); Novonet149-801 (a heat bonded grating pattern material containing about 69% rayon, about 25% polypropylene and about 6% cotton and having a basis weight of about 90 gsm, available from Veratec, Inc., Walpole, MA); Novonet149-191 (a heat bonded lattice pattern material containing about 69% rayon, about 25% polypropylene and about 6% cotton and having a basis weight of about 120 gsm, available from Veratec, Inc, Walpole, MA); HEF Nubtex 149-801 (nubbed, pore formed wet entangled material containing about 100% polyester and having a basis weight of about 84 gsm, available from Veratec, Inc., Walpole, MA); Keybak951V (a dry formed pore formed material containing about 75% rayon, about 25% acrylic fiber and having a basis weight of about 51 gsm, available from Chicopee, New Brunswick, NJ); Keybak1368 (porous material containing about 75% rayon, about 25% polyester and having a basis weight of about 47 gsm, available from Chicopee, New Brunswick, NJ); Douralace1236 (porous, wet entangled material containing about 100% rayon and having a basis weight of about 48 gsm to about 138 gsm, available from Chicopee, New Brunswick, NJ); Douralace5904 (porous, wet entangled material containing about 100% polyester and having a basis weight of about 48 gsm to about 138 gsm, available from Chicopee, New Brunswick, NJ); ChicopeeCarded wet containing 5763 (about 70% rayon, about 30% polyester, and optionally up to about 5% w / w latex binder (based on acrylate or EVA) and having a basis weight of about 60 gsm to about 90 gsm Entangled material (8 × 6 pores per inch, 3 × 2 pores per cm), available from Chicopee, New Brunswick, NJ); Chicopee9900 series (e.g. Chicopee 9931, 62 gsm, 50/50 rayon / polyester, and Chicopee 9950, 50 gsm, 50/50 rayon / polyester) (50% rayon / 50% polyester to 0% rayon / 100% A carded, wet entangled material containing a fiber composition of polyester or 100% rayon / 0% polyester and having a basis weight of about 36 gsm to about 84 gsm; sold by Chicopee, New Brunswick, NJ); Sontara 8868 (wet entangled material containing about 50% cellulose and about 50% polyester and having a basis weight of about 72 gsm, sold by Dupont Chemical Corp.). Preferred nonwoven base materials have a basis weight of about 24 gsm to about 96 gsm, more preferably about 36 gsm to about 84 gsm, most preferably about 42 gsm to about 78 gsm.

The nonwoven layer can also be a polymeric mesh sponge described in European Patent Application No. 702550 A1, published March 27, 1996, which is hereby incorporated by reference in its entirety. The polymeric mesh sponge comprises a plurality of plies of extruded tubular reticulated mesh made of strong flexible polymers or nylons such as addition polymers of olefin monomers and polyamides of polycarboxylic acids.

The nonwoven layer may also include a molded film and a composite, ie, a multi-ply material that includes a molded film. Preferably, the molding film comprises plastic that tends to be soft on the skin. Suitable soft plastic molded films include, but are not limited to, polyolefins such as low density polyethylene (LDPE). In the case where the nonwoven layer comprises a plastic molding film, it is preferable that the nonwoven layer is voided, such as a macropore or a micropore, so that the layer is fluid permeable. In one embodiment, the nonwoven layer comprises only microporous plastic molded films. The surface modifications of the micropores, ie the protruding sides, are preferably located on the inner surface of the second layer and preferably towards the interior of the substrate, ie the member of the therapeutic efficacy. Without wishing to be bound by theory, in certain embodiments involving voids having a petal shaped edge surface deformation, when the surface deformation of the voids is directed towards a therapeutically potent member, the application of pressure to the article by hand results in the petaled edge of the surface deformation. It is believed that prolonging the useful life of the article is achieved by creating a number of valves on the inner surface of the layer that, in fact, meter out the therapeutically potent member contained in the article by folding it inside.

In another embodiment, the nonwoven layer comprises a plastic molded film having both micropores and macropores. In this embodiment, the nonwoven layer is well suited for contacting the site to be treated therapeutically while providing a cloth-like feel of the microporous formed film. Preferably, in this embodiment, the surface deformation of the micropores is opposite to the surface deformation of the macropores on the nonwoven layer. In such a case, it is believed that the large voids form rich bubbles by maximizing the overall wetting / lathering of the article by the three-dimensional thickness formed from the surface deformation under constant pressure and reduced pressure during use of the article.

In any case, the nonwoven layer comprising the molded film has at least about 100 voids / cm ² , more preferably at least 500 voids / cm ² , even more preferably at least about 1000 voids / cm ² , most preferably Preferably a substrate having at least about 1500 voids / cm ² . More preferred embodiments of the invention range from about 5 cm ³ / cm ² -s to about 70 cm ³ / cm ² -s, more preferably from about 10 cm ³ / cm ² -s to about 50 cm ³ / cm ^2- s, most preferably a nonwoven layer having a water flow rate from about 15 cm ³ / cm ² -s to about 40 cm ³ / cm ² -s.

Suitable molding films and composites comprising molding films useful for the nonwoven layers of the present invention are commonly assigned in US Pat. No. 4,342,314 to Radel et al., Issued August 3, 1982, which is hereby incorporated by reference in its entirety. Co-pending Application US Serial No. 08 / 326,571 and PCT Application US95 / 07435 (filed June 12, 1995, published January 11, 1996) and US Pat. No. 4,629,643 (Curro et al., 12, 1986). Per month, but not limited thereto. Further, the nonwoven layer can be a molded film composite that includes one or more nonwovens and one or more molded films in which the layer is vacuum formed. Suitable molded film composites include, but are not limited to, vacuum laminated composite molded film materials formed by combining a carded polypropylene nonwoven having a basis weight of 30 gsm with a molded film.

In addition, the nonwoven layer and any additional layers are preferably bonded to each other to maintain the integrity of the article. The bond can be used for spot bonds (eg hot point bonds), continuous connections (eg, stacking, etc.) to discontinuous patterns, or bonds at the outer edge (or periphery) of the layer and / or at separate locations. Or combinations thereof. When spot bonds are used in the present article, the spot bonds are preferably separated by a distance of about 1 cm or more. However, in any example, the bonds can be arranged such that geometric shapes and patterns, such as diamonds, circles, squares, etc., are created on the outer surfaces of the resulting articles and layers.

It is also contemplated that in the articles of the present invention the nonwoven layer and any additional layers may be surface modified to form a single composite layer with two sides having different textures. Thus, in fact, it can be understood that a water insoluble substrate comprises a single composite layer with double textured sides or surfaces.

In any case, the bonding area present between the nonwoven layer and any additional layer is about 50% or less, preferably about 15% or less, more preferably about 10% or less, most preferably of the total surface area of the layer. It is preferably about 8% or less.

Each layer discussed herein includes two or more surfaces, i.e., an inner surface and an outer surface, each of which may have the same or different textures and degrees of polishing. Preferably, the article of the invention comprises a substrate and therefore comprises a soft layer on the skin. However, different texture substrates can occur with the use of different combinations of materials or with different fabrication processes or combinations thereof. For example, dual textured water insoluble substrates can be made to provide a personal care article that has the advantage of having a more abrasive face for peeling and a softer, absorbent face for mild cleansing and / or therapeutic treatments. In addition, by making the individual layers of the substrate have different shades, it may help the user to further distinguish the surface.

In addition, each of the layers of the article and the article itself can be made into a wide variety of shapes and shapes, such as flat pads, thick pads, thin sheets, ball tools, indefinite tools. The exact size of the layer will depend on the intended use and article properties, and the surface area may range from about 1 in ² to about several hundred in ² . Particularly convenient layers and articles forms have a surface area of about 5 in ² to about 200 in ² , preferably about 6 in ² to about 120 in ² , more preferably about 15 in ² to about 100 in ² , and a thickness of about Square, round, rectangular, hourglass, mitt or egg-shaped, from 0.5 mm to about 50 mm, more preferably from about 1 mm to about 25 mm, more preferably from about 2 mm to about 20 mm Included, but not limited to.

Wear Value Methodology

Abrasion values represent the "non-abrasion" properties of the nonwoven layer of the article. The nonwoven layer of the present invention is mildly peeled but not rough to the skin. Thus, the wear value measurement involves using a mechanical device to rub the substrate along the test surface and then using the different analytical techniques to examine the scratch marks produced on the test surface.

The following apparatus is required for the methodology.

1. Martindale Toothbrush Wear and Wear Tester: Model 103, serial number 103-1386 / 2 and above. James H. Heal and Co. Ltd. Manufactured by Martindale 07-01-88. Textile test and QC device. Foot area: 43 x 44 mm. 1 Kg weight.

2. 11 x 8 cm of capped polystyrene pieces. Clean general purpose polystyrene layer on white, high impact polystyrene, for example EMA model supply no. SS-20201L.

3. The substrate to be tested.

4. Glossimeters, eg Sheen Tri-Microgloss 20-60-85.

The plastic protective coating on the side to be scratched is removed and rinsed with ethanol (no paper is used) to produce a piece of polystyrene for scratches. Place the pieces on a non-wear surface and allow the pieces to air dry. The polystyrene pieces are then attached to the bottom of the Martindale abrasion tester using tape along the edges. In the center under the path of the scrubbing device, the pieces are aligned with the length of the pieces in the direction of movement. Cut a 2.5 "x 2.5" substrate sample. Align the machine direction of the substrate in the reciprocating direction, and attach the substrate sample to the scrubbing foot of the Martindale abrasion tester using double sided tape. Secure the scrubbing foot assembly to the instrument with the provided screws. A 1 kg weight is applied to the top of the scrubbing foot assembly and ensures that the scrubbing foot moves in only one direction (front and rear). Cover the entire Martindale abrasion tester with a safety screen. Set up and run the machine to perform 50 cycles per minute (frequency = 0.833 Hz). Once the machine has stopped, the foot assembly is removed and the piece of polystyrene is lifted off the bottom of the machine. A label indicating that this substrate was used is placed on the polystyrene and stored in a plastic bag.

The pieces are then analyzed. The pieces are placed on a black cardboard board and five or more samples of the same substrate are analyzed to obtain a reproducible average. The glossmeter is placed at right angles (with the light beam perpendicular to the scratches) and centered over the scratched side of the polystyrene piece. A 20 ° angle is selected and the sample is measured to calculate the wear value. As the wear value decreases, the scratch or non-wear characteristics of the substrate increase.

Lack of therapeutic efficacy

The article of the present invention further contains a safe effective amount of a therapeutically potent absence. The potency member is disposed adjacent to the water insoluble substrate and contains about 10% to about 1000% by weight of the therapeutically potent composition relative to the water insoluble substrate. The potent composition further contains a safe effective amount of anionic polymer and a safe effective amount of cationic surfactant, wherein the composition forms coacervate when the article is exposed to water.

Anionic polymer

Articles of the invention may contain a safe effective amount of anionic polymers. Suitable anionic polymers include polyacrylic acid polymers, polyacrylamide polymers, copolymers of acrylic acid, acrylamides, and other natural or synthetic polymers (eg, polystyrenes, polybutenes, polyurethanes, etc.), naturally occurring rubbers, and combinations thereof. It may be selected from the group consisting of. Suitable rubbers include alginate (eg propylene glycol alginate), pectin, chitosan (eg chitosan lactate), and modified rubbers (eg starch octenyl succinate), and combinations thereof. Preferred anionic polymers are selected from the group consisting of polyacrylic acid polymers, polyacrylamide polymers, copolymers of acrylic acid, chitosan, alginates, pectins, and combinations thereof. Preferred articles of the invention comprise anionic polymers having from about 0.01% to about 20%, more preferably from about 0.05% to about 10%, most preferably from about 0.1% to about 5% by weight of the coacervate forming composition It is contained in weight%.

Cationic surfactant

Articles of the invention contain a safe effective amount of cationic surfactant. Preferably, the article comprises about 10% to about 1,000% by weight of surfactant based on the water-insoluble substrate, preferably about 50% to about 600% by weight, more preferably about 100% to about 250% by weight It is contained in%.

In one embodiment, the cationic surfactant is a foaming surfactant. Suitable cationic foaming surfactants include, but are not limited to, fatty amines, di-fatty quaternary amines, tri-fatty quaternary amines, imidazolinium quaternary amines, and combinations thereof. Suitable fatty amines include monoalkyl quaternary amines such as cetyltrimethylammonium bromide. Suitable quaternary amines are dialkylamidoethyl hydroxyethylmonium methosulfates. However, fatty amines are preferred. If the cationic foaming surfactant is the main foaming surfactant of the cleansing member, it is preferred to use a foaming booster. In addition, it has been found that nonionic surfactants are particularly useful in combination with such foaming surfactants.

Cationic surfactants, on the other hand, are typically categorized as non-foaming surfactants but can be used in the articles of the present invention, provided they do not adversely affect the desired efficacy of the article.

Non-limiting examples of cationic surfactants useful herein are described in McCutcheon's, Detergents and Emulsifiers , North American Edition (1986), allured Publishing Corporation; And McCutcheon's, Functional Materials , North American Edition (1992); All of which are incorporated herein by reference in their entirety.

Non-limiting examples of cationic surfactants useful herein include cationic alkyl ammonium salts such as those having the formula:

_{R 1 R 2 R 3 R 4} N + X -

(Wherein, R ₁ has a carbon number of from about 12 to about 18 alkyl groups, or having from about 12 to about 18 aromatic, it is selected from an aryl or alkaryl group; R _2, R _3, and R ₄ are hydrogen, having from about 1 Independently selected from alkyl groups from about 18 to about 18, or aromatic, aryl or alkaryl groups from about 12 to about 18 carbon atoms; X is chloride, bromide, iodide, acetate, phosphate, nitrate, sulfate, methyl sulfate, Anion selected from ethyl sulfate, tosylate, lactate, citrate, glycolate, and mixtures thereof). Additionally, the alkyl group may also contain ether linkages, or hydroxy or amino group substituents (eg, the alkyl group may contain polyethylene glycol and polypropylene glycol moieties).

More preferably, R ₁ is an alkyl group having from about 12 to about 18 carbon atoms; R ₂ is selected from hydrogen or an alkyl group having from about 1 to about 18 carbon atoms; R ₃ and R ₄ are independently selected from hydrogen or an alkyl group having from about 1 to about 3 carbon atoms; X is as described in the paragraph above.

Most preferably, R ₁ is an alkyl group having from about 12 to about 18 carbon atoms; R ₂ , R ₃ , and R ₄ are selected from hydrogen or alkyl groups of about 1 to about 3 carbon atoms; X is as described above.

Alternatively, other useful cationic surfactants include amino-amides, wherein R ₁ in the formula is alternatively R ₅ CO- (CH ₂ ) _n -wherein R ₅ is about 12 to about 22 alkyl groups, n is an integer of about 2 to about 6, more preferably about 2 to about 4, most preferably about 2 to about 3. Non-limiting examples of such cationic emulsifiers include stearamidopropyl PG-dimonium chloride phosphate, stearamidopropyl ethyldimonium etosulphate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearamidopropyl Dimethyl cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride, stearamidopropyl dimethyl ammonium lactate, and mixtures thereof.

Non-limiting examples of quaternary ammonium salt cationic surfactants include cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium Bromide, lauryl dimethyl ammonium chloride, lauryl dimethyl ammonium bromide, stearyl dimethyl ammonium chloride, stearyl dimethyl ammonium bromide, cetyl trimethyl ammonium chloride, cetyl trimethyl ammonium bromide, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl Trimethyl Ammonium Chloride, Stearyl Trimethyl Ammonium Bromide, Lauryl Dimethyl Ammonium Chloride, Stearyl Dimethyl Cetyl Ditallow Dimethyl Ammonium Chlora Dide, disetyl ammonium chloride, disetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide, distearyl ammonium chloride, distearyl ammonium bromide, dicetyl methyl ammonium chloride, dicetyl methyl ammonium bromide, dilauryl methyl ammonium Chloride, dilauryl methyl ammonium bromide, distearyl methyl ammonium chloride, distearyl dimethyl ammonium chloride, distearyl methyl ammonium bromide, and mixtures thereof. Additional quaternary ammonium salts include those in which the C ₁₂ to C ₂₂ alkyl carbon chain is derived from tallow fatty acids or coconut fatty acids. The term "tallow" is typically C ₁₆ to C ₁₈ refers to an alkyl group derived from having a mixture of alkyl chain, tallow fatty acids (usually hydrogenated tallow fatty acids) in the range. The term "coconut" refers to an alkyl group derived from coconut fatty acids, typically having a mixture of alkyl chains in the range of C ₁₂ to C ₁₄ . Examples of quaternary ammonium salts derived from such tallow and coconut sources include ditallow dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, di (hydrogenated tallow) dimethyl ammonium chloride, di (hydrogenated tallow) dimethyl ammonium acetate, Ditallow Dipropyl Ammonium Phosphate, Ditlow Dimethyl Ammonium Nitrate, Di (coconutalkyl) dimethyl Ammonium Chloride, Di (coconutalkyl) dimethyl Ammonium Bromide, Tallow Ammonium Chloride, Coconut Ammonium Chloride, Stearamidopropyl PG-Dimonium Chloride Phosphate, Stearamidopropyl Ethyldimonium Ethosulfate, Stearamidopropyl Dimethyl (Mistyl Acetate) Ammonium Chloride, Stearamidopropyl Dimethyl Cetearyl Ammonium Tosylate, Stearamidopropyl Dimethyl Ammonium Chlora De, stearic amido propyl dimethyl ammonium also include lactate, and mixtures thereof.

Preferred cationic surfactants useful herein include the group consisting of dilauryl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dimyristyl dimethyl ammonium chloride, dipalmityl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, and mixtures thereof Included are those selected from.

Without being bound by theory, it is believed that the anionic polymer and the cationic surfactant coexist in the form of coacervate upon exposure to an aqueous medium. As used herein, "coacervate" means the associated phase separation of a countercharged polymer and a surfactant or polymer and a polymer resulting from dilution of the product. The result is coacervate, which is an aqueous gel-like substance formed. Once formed, the coacervate alone in the present composition can improve the appearance of dry skin once applied. Moreover, the coacervate can act as a mechanism for the deposition of absence of therapeutic efficacy, thereby facilitating the substantivity of the agent to the skin. As the direct adherence of skin and / or hair increases, the efficacy of the formulation increases.

Surface-to-Saturation Ratio Methodology

The article of the invention comprises substantially no therapeutic efficacy on the surface of the substrate. The expression “substantially on the surface of the substrate” means that the surface-to-saturation ratio is greater than about 1.25, preferably greater than about 1.5, more preferably greater than about 2.0, even more preferably greater than about 2.25, most preferably 2.5. It means exceed. Surface to saturation ratio is the ratio of measurement of agonists on the surface of the substrate. These measurements were obtained using an Attenuated Total Reflectance (ATR) FT-IR spectrometer well known to those skilled in the art of analytical chemistry.

Many existing methods of applying conditioning agents to substrates utilize processes and / or product rheology that are inadequate for the purposes of the present invention. For example, if the conditioning agent is applied to the entire substrate in a so-called "dip and nip" process, which is a process of soaking the substrate web into a fluid bath of conditioning agent and then pressing the substrate web through a metering roll, There is no opportunity for effective direct delivery of the composition out of the fabric and onto other surfaces during use. In addition, many articles of the present invention utilize sufficient loading of conditioning agents onto a substrate to provide an effective overall body benefit, which generally requires a loading rate of about 100 to 200 weight percent based on the weight of the dry substrate. . Known personal care tools utilizing such high loading levels essentially avoid coping with the aesthetic problems that may arise from these high loadings by evenly distributing the loading throughout the substrate, including inside the substrate. The Applicant surprisingly finds that a high loading of conditioning agent can be maintained on the surface of the article, which advantageously allows the direct delivery of the agonist from the substrate to the surface to be treated during use, while the opportunity of the present invention can be met. It has been found that the composition can deliver improved aesthetics.

The measurement procedure is as follows.

Instrument setup : A BioRad FTS-7 spectrometer manufactured by Bio Rad Labs of the Digital Laboratory Division (Cambridge, MA) was used to collect infrared spectra. Typically, 100 scans were measured at a resolution of 4 cm ^-1 . Acquisition Optics is available from Graseby Specac, Inc. It consists of a 60-degree ZnSe ATR crystal of the flat plate manufactured by (located in Fairfield, CT). Data was collected at 25 ° C., and Galactic Industries Corp. Analyzes were performed using Grams 386 software distributed by Salem, NH. The crystals were washed with a suitable solvent before the measurement. Samples were placed on ATR crystals and kept under a constant 4 kg weight.

Experimental procedure

(1) Measure the reference (background) spectrum of the washed and air dried cells.

(2) First, a substrate to which no agonist is applied is selected, and the selected substrate includes an outer surface of the article. The substrate is placed on top of the ATR crystal, which is the outer surface for the crystal. First, the substrate is placed flat on the measuring table. Then 4 kg weight is added on the substrate. The spectrum is then measured (typically 100 scans at 4 cm ^-1 resolution). Since the absorbance of the substrate alone is confirmed, the substrate serves as an internal standard. Identify the major substrate peaks and wavelength numbers.

(3) The above procedure is repeated for the description of the article to which the agonist is applied. Does not correspond to a substrate peak as previously observed; Or identify the peak height of the primary agonist, which is the highest observed peaks that correspond to the previously observed substrate peaks but show a significant percentage increase in absorbance due to the presence of the conditioning agent. The number of wavelengths and the absorbance of several agonist peaks are recorded.

(4) From the spectrum measured in the third step, a substrate peak generated at the number of wavelengths measured in the second step but not corresponding to one of the primary agonist peaks selected in the third step is selected. The absorbance and the selected number of wavelengths are recorded from the absorbance spectrum of the third step.

(5) The ratio of the peak height of each agonist determined in step 3 to the peak height of the substrate measured in step 4 is calculated. The highest number of groups represents the surface to saturation ratio of the article.

The following includes some examples:

materials* Substrate peak and peak height conditioner for hair Conditioner peak height ratio Batting (blending of polyester bonded with 70% PET / PE bicomponent fiber) 0.0865 (C = O peak at 1710 cm ^-1 ) Glycerin (CO peak at 1030 cm ^-1 ) 0.181 2.09 Batting (blending of polyester bonded with 70% PET / PE bicomponent fiber) 0.0865 (C = O peak at 1710 cm ^-1 ) Hydrocarbons (CH peak at 2923 cm ^-1 ) 0.160 1.85 Wet Tangle 70% Rayon / 30% Polyester 0.0333 (C = O peak at 1710 cm ^-1 ) Glycerin (CO peak at 1030 cm ^-1 ) 0.0684 2.05

This type of substrate is readily available, for example, from PGI Nonwovens (Benson, NC).

Moisture Retention Methodology

As described above, the articles of the present invention are considered to be "substantially dry." As used herein, the phrase "substantially dry" indicates that the article of the invention is less than about 0.95 gms, preferably less than about 0.75 gms, more preferably less than about 0.5 gms, even more preferably less than about 0.25 gms, even more. Preferably less than about 0.15 gms, most preferably less than about 0.1 gms. The moisture retention is a measure of the dry feel that users perceive as opposed to a "wet" wipe when touching an article of the present invention.

In order to determine the moisture retention of products based on this article and other disposable substrates, the following equipment and materials are needed.

Bounty white paper towel Procter & Gamble SKU 37000 63037 Base Weight = 42.14 gsm Scale Exactly 0.0g Lexan 0.5 "thick, large enough to cover completely and weighs 1000g Weight 2000g weight or combination even at 2000g

Then, two paper towels are weighed separately and each weight is recorded. A piece of paper towel is placed on a flat surface (eg lab bench). Place the sample item on the towel. Place another piece of paper towel on top of the specimen. The lexan is then placed and the 2000 g weight (s) is placed on the sandwiched specimen. Wait for 1 minute. After 1 minute, the weight (s) and lexan are removed. Weigh the top and bottom paper towels and record the weight.

For both the top and bottom paper towels, the moisture retention is calculated by subtracting the initial paper towel weight from the final weight (after 1 minute). The weight difference obtained for the paper towels of the top and bottom are summed. Assuming that a large number of articles have been tested, the moisture retention is calculated by averaging the total weight differences.

Composite article embodiment

The article of the present invention may also be packaged together with additional articles suitable to provide a separate efficacy, such as aesthetic, therapeutic, functional, etc., not provided individually or by the main article, to form a personal care kit. Can be. The additional article of such personal care kit preferably comprises a water-insoluble substrate comprising at least one layer and a cleansing member containing a therapeutically potent member or foaming surfactant disposed or incorporated in the substrate layer of the additional article. It contains.

Additional articles of the invention may also provide functional efficacy in addition to or in place of therapeutic or aesthetic efficacy. By way of example, the accessory article may be useful as a drying tool suitable for use in assisting the removal of water from the skin or hair after the shower or bath is over.

Multiple Chamber Embodiment

In addition, the article of the present invention may comprise one or more chambers. These chambers or compartments result from the connection (eg, bonding) of the substrate layers to each other at various locations to define the enclosed area. Such chambers are useful, for example, to separate various article members from one another, such as to separate a surfactant containing cleansing member and a conditioning agent. Separated article members that provide therapeutic or aesthetic or cleansing efficacy may include solubilizing, emulsifying, mechanically moving, perforating, popping, rupturing, squeezing or delaminating the substrate layer that forms part of the chamber. It may be released from the chambers in a variety of ways, including, but not limited to.

Any member

Articles of the invention may include a variety of other members conventionally used in the form of a given product, provided they do not unacceptably alter the efficacy of the invention. The optional members must be suitable for application to human skin and hair, i.e. when incorporated into an article, they are free of excessive toxicity, incompatibility, instability, allergic reactions, etc. without any serious medical or formulator judgment of human skin. Should be suitable for use in contact with The CTFA Cosmetic Ingredient Handbook, 2nd Edition (1992) describes a wide variety of non-limiting cosmetic and pharmaceutical ingredients commonly used in the skin care industry, suitable for use in the articles of the present invention. Examples of member groups include: enzymes, abrasives, skin dermabrasions, absorbents, aesthetic elements such as fragrances, pigments, pigments / colorants, essential oils, skin sensitizers, astringents and the like (eg, clove oil, Menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, hamamelis distillate, antiacne agents (eg resorcinol, sulfur, salicylic acid, erythromycin, zinc, etc.), caking Inhibitors, antifoams, additional antibacterial agents (e.g., iodopropyl butylcarbamate), antioxidants, binders, biological additives, buffers, bulking agents, chelating agents, chemical additives, colorants, cosmetic astringents, Cosmetic biocides, denaturants, drug astringents, external analgesics, film formers or materials, such as polymers to aid film formability and direct adhesion of compositions, such as eicosene and vinyl Copolymers of pyrrolidone), wetting agents, opacifying agents, pH adjusting agents, propellants, reducing agents, sequestering agents, skin whitening agents (or lightening agents) (e.g. hydroquinone, kojic acid, ascorbic acid, magnesium ascorbyl phosphate, ascorbyl) Glucosamine), skin soothing and / or healing agents (such as panthenol and derivatives (such as ethyl panthenol), aloe vera, pantothenic acid and derivatives thereof, allantoin, bisabolol, and dipotassium glycyrizinate), prevention of skin wrinkles, Skin treatment agents (eg, alpha-hydroxy acids such as lactic acid and glycolic acid and beta-hydroxy acids such as salicylic acid), including agents for delaying, retarding, and / or reversing, thickeners, hydrocolloids, certain zeolites, And vitamins and derivatives thereof (eg, tocopherol, tocopherol acetate, beta carotene, retinic acid, retinol, retinoids, retinyl palmitate, niacin, Niacinamide and the like). Articles of the invention may include carrier members known in the art. The carrier may comprise one or more compatible liquid or solid filler diluents or vehicles suitable for application to the skin or hair.

The article of the present invention may optionally comprise one or more of the above optional members. Preferred articles include vitamin compounds, skin treatments, anti acne, anti-wrinkle agents, anti-skin atrophy agents, anti-inflammatory agents, local anesthetics, artificial tanning and tanning promoters, antibacterial agents, antifungal agents, antiviral agents, enzymes, sunscreens, antioxidants, skin And optionally contains a safe effective amount of a therapeutically effective absence comprising a therapeutic agent selected from the group consisting of dermabrasions, and combinations thereof. As used herein, “safely effective amount” is sufficient to significantly induce a positive effect or benefit, but serious side effects (eg, excessive toxicity or allergic reactions) are low enough to avoid, ie, reasonable within the scope of sound medical judgment. By amount of compound or absence that provides a ratio of efficacy to risk.

Any absence useful herein can be categorized by treatment or aesthetic efficacy or their assumed mode of action. However, it should be understood that any absence useful herein may in some cases provide more than one treatment or aesthetic effect or act through more than one mode of action. Accordingly, the categorization herein is for convenience and is not intended to limit the absence of any particular application or listed applications. Also, where applicable, pharmaceutically acceptable salts in the absence are useful herein.

Cationic polymer

The personal care composition of the present invention may optionally contain a safe effective amount of cationic polymer. The cationic polymer can be selected from the group consisting of natural backbone quaternary ammonium polymers, synthetic backbone quaternary ammonium polymers, natural backbone amphoteric polymers, synthetic backbone amphoteric polymers, and combinations thereof.

More preferably, the cationic polymer is polyquaternium-4, polyquaternium-10, polyquaternium-24, PG-hydroxyethylcellulose alkyldiammonium chloride, guar hydroxypropyltrimonium chloride, hydride Natural backbone quaternary ammonium polymers selected from the group consisting of oxypropylgua hydroxypropyltrimonium chloride, and combinations thereof; Polyquaternium-2, Polyquaternium-6, Polyquaternium-7, Polyquaternium-11, Polyquaternium-16, Polyquaternium-17, Polyquaternium-18, Polyquaternium-28, Polyquater Nium-32, polyquaternium-37, polyquaternium-43, polyquaternium-44, polyquaternium-46, polymethacylamidopropyl trimonium chloride, acrylamidopropyl trimonium chloride / acrylamide copolymer Synthetic backbone quaternary ammonium polymers selected from the group consisting of; Natural backbone amphoteric polymers selected from the group consisting of chitosan, quaternized proteins, hydrolyzed proteins and combinations thereof; Polyquaternium-22, polyquaternium-39, polyquaternium-47, adipic acid / dimethylaminohydroxypropyl diethylenetriamine copolymer, polyvinylpyrrolidone / dimethylaminoethyl methacrylate copolymer, vinyl Caprolactam / polyvinylpyrrolidone / dimethylaminoethylmethacrylate copolymer, vinyl caprolactam / polyvinylpyrrolidone / dimethylaminopropylmethacrylamide terpolymer, polyvinylpyrrolidone / dimethylaminopropylmethacrylamide And synthetic backbone amphoteric polymers selected from the group consisting of copolymers, polyamines, and combinations thereof. Even more preferably, the cationic polymer is a synthetic backbone amphoteric polymer. Even more preferably the cationic polymer is a polyamine.

When the cationic polymer is a polyamine, the cationic polyamine polymer is preferably selected from the group consisting of polyethyleneimine, polyvinylamine, polypropyleneimine, polylysine and combinations thereof. Even more preferably, the cationic polyamine polymer is polyethyleneimine.

In certain embodiments where the cationic polymer is a polyamine, the polyamine can be modified hydrophobicly or hydrophilically. In this example, the cationic polyamine polymer is selected from the group consisting of benzylated polyamines, ethoxylated polyamines, propoxylated polyamines, alkylated polyamines, amidated polyamines, esterified polyamines, and combinations thereof. The coacervate forming composition comprises cationic polymer at about 0.01% to about 20%, more preferably about 0.05% to about 10%, most preferably about 0.1% to about 5% by weight of the coacervate forming composition. It contains.

The composition of the present invention contains from about 0.01% to about 20%, more preferably from about 0.05% to about 10%, most preferably from about 0.1% to about 5% by weight of the cationic polymer do.

Hydrophobic Conditioning Agent

Articles of the present invention may contain one or more hydrophobic conditioning agents useful for imparting conditioning efficacy to the skin or hair during use of the article. The article of the present invention comprises a hydrophobic conditioning agent with respect to the water-insoluble substrate, preferably from about 0.5% to about 1,000% by weight, more preferably from about 1% to about 200% by weight, most preferably about 10% by weight. To about 100% by weight.

The hydrophobic conditioning agent may be selected from one or more hydrophobic conditioning agents such that the weighted arithmetic mean solubility parameter of the hydrophobic conditioning agent is 10.5 or less. Based on the above mathematical definition of solubility parameters, for example, for hydrophobic conditioning agents containing two or more compounds, the weighted arithmetic mean solubility parameter required, i.e. 10.5, even when the individual solubility parameter of one of the compounds is greater than 10.5 It can be seen that the following can be achieved.

Solubility parameters are well known to formulation chemists in the art and are routinely used as guidelines for determining compatibility and solubility of materials within the formulation process.

The solubility parameter δ of a chemical compound is defined as the square root of the aggregation energy density of that compound. Typically, the solubility parameter of a compound is calculated from the tabulated values of the molar volume of the component of the compound and the addition group contribution to the heat of vaporization using the formula:

(Wherein, Σ _i E _i = sum of contribution of heat of vaporization addition group, Σ _i m _i = sum of contribution of molar volume addition group).

Standard tabulations of heat of vaporization and molar volume adder contributions to a wide variety of atoms and groups of atoms are described in Barton, AFM Handbook of Solubility Parameters , CRC Press, Chapter 6, Table 3, pp, which is incorporated herein by reference in its entirety. . 64-66 (1985). The solubility parameter equation, in its entirety, which is reflected by reference in its entirety, [Fedors, RF, "A Method for Estimating Both the Solubility Parameters and Molar Volumes of Liquids", Polymer Engineering and Science, vol. 14, no. 2, pp. 147-154 (February 1974).

The solubility parameter follows the mixture law that the solubility parameter for a mixture of substances is given by the weighted arithmetic mean (ie, weighted average) of the solubility parameters for each component of the mixture. Handbook of Chemistry and Physics , 57th edition, CRC Press, p. C-726 (1976-1977).

Formulation chemists typically use and report solubility parameters in (cal / cm 3) ^1/2 units. In Handbook of Solubility Parameters , the tabulated values of addition group contribution to the heat of vaporization are reported in kJ / mol. However, these formulated heat of vaporization values are easily converted to cal / mol using the following well known correlation:

1 J / mol = 0.239006 cal / mol and 1000 J = 1 kJ

Gordon, AJ et al., The Chemist's Companion , John Wiley & Sons, pp. 456-463, (1972).

In addition, the solubility parameters for a wide variety of chemicals are tabulated. A tabulation of solubility parameters is shown in the Handbook of Solubility Parameters cited above. See also, "Solubility Effects In Product, Package, Penetration, And Preservation", CD Vaughan, Cosmetics and Toiletries , vol. 103, October 1988, pp. 47-69].

Non-limiting examples of hydrophobic conditioning agents include mineral oil, petrolatum, lecithin, hydrogenated lecithin, lanolin, lanolin derivatives, branched chain hydrocarbons of C7 to C40, C1 to C30 alcohol esters of C1 to C30 carboxylic acids, C2 C1-C30 alcohol ester of ˜C30 dicarboxylic acid, monoglyceride of C1-C30 carboxylic acid, diglyceride of C1-C30 carboxylic acid, triglyceride of C1-C30 carboxylic acid, ethylene of C1-C30 carboxylic acid Glycol monoesters, ethylene glycol diesters of C1-C30 carboxylic acids, propylene glycol monoesters of C1-C30 carboxylic acids, propylene glycol diesters of C1-C30 carboxylic acids, C1-C30 carboxylic acid monoesters of sugar, and Polyester, polydialkylsiloxane, polydiarylsiloxane, polyalkoxysiloxane, cyclomethicone of 3 to 9 silicon atoms, vegetable oil, hydrogenated vegetable oil, polypropylene glycol C4 ~ And those selected from the group consisting of C20 alkyl ethers, di C8 to C30 alkyl ethers, and combinations thereof.

Mineral oils, also known as petroleum liquids, are mixtures of liquid hydrocarbons obtained from petroleum. The Merck Index, 10th edition, no. 7048, p., Incorporated herein by reference in their entirety. 1033 (1983) and the International Cosmetic Ingredient Dictionary, 5th edition, vol. 1, p. 415-417 (1993).

Petroleum, also known as petroleum jelly, is a colloidal system of non-chain solid hydrocarbons and high boiling liquid hydrocarbons, most of which are contained within micelles. The Merck Index, 10th edition, no. 7047, p., Incorporated herein by reference in their entirety. 1033 (1983); Schindler, Drug. Cosmet. Ind. , 89 , 36-37, 76, 78-80, 82 (1961); And International Cosmetic Ingredient Dictionary, 5th edition, vol. 1, p. 537 (1993).

Lecithin is also useful as a hydrophobic conditioning agent. It is a naturally occurring mixture of diglycerides of certain fatty acids, linked to choline esters of phosphoric acid.

Useful herein are straight and branched chain hydrocarbons having about 7 to about 40 carbon atoms. Non-limiting examples of such hydrocarbon materials include dodecane, isododecane, squalane, cholesterol, hydrogenated polyisobutylene, docoic acid (ie, C ₂₂ hydrocarbons), hexadecane, isohexadecane (Presperse (South Plainfield, NJ) Permethyl) Hydrocarbons sold as 101A). Also useful are C7-C40 isoparaffins, which are C7-C40 branched hydrocarbons. Polydecenes, branched liquid hydrocarbons, are also useful here, which are commercially available under the trade name Puresyn 100 from Mobile Chemical (Edison, NJ). And Puresyn 3000 It is marketed by.

Also useful are C1-C30 alcohol esters of C1-C30 carboxylic acids and C2-C30 dicarboxylic acids, including straight and branched chain materials, as well as aromatic derivatives. Moreover, monoglyceride of C1-C30 carboxylic acid, diglyceride of C1-C30 carboxylic acid, triglyceride of C1-C30 carboxylic acid, ethylene glycol monoester of C1-C30 carboxylic acid, C1-C30 carboxylic acid Esters such as ethylene glycol diesters, propylene glycol monoesters of C1-C30 carboxylic acids, and propylene glycol diesters of C1-C30 carboxylic acids are also useful. Straight chain, branched and aryl carboxylic acids are also included here. Propoxylated and ethoxylated derivatives of these materials are also useful. Non-limiting examples include diisopropyl sebacate, diisopropyl adipate, isopropyl myristate, isopropyl palmitate, myristyl propionate, ethylene glycol distearate, 2-ethylhexyl palmitate, isodecyl neopenta Noate, di-2-ethylhexyl maleate, cetyl palmitate, myristyl myristate, stearyl stearate, cetyl stearate, behenyl behenate, dioctyl maleate, dioctyl sebacate, diisopropyl adipate Cetyl octanoate, diisopropyl dilinoleate, caprylic / capric triglycerides, PEG-6 caprylic / capric triglycerides, PEG-8 caprylic / capric triglycerides, and combinations thereof Water is included.

Various C1-C30 monoesters and polyesters of sugars and related materials are also useful. The ester is derived from sugar or polyol moieties and one or more carboxylic acid moieties. Depending on its constituent acids and sugars, the esters may be in liquid or solid form at room temperature. Examples of liquid esters include: glucose tetraoleate, glucose tetraester of soybean oil fatty acid (unsaturated), mannose tetraester of mixed soybean oil fatty acid, galactose tetraester of oleic acid, arabinose tetraester of linoleic acid, xylose Tetralinoleate, galactose pentaoleate, sorbitol tetraoleate, sorbitol hexaester of unsaturated soybean oil fatty acid, xylitol pentaoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, sucrose Octaoleate, and mixtures thereof. Examples of solid esters include: sorbitol hexaester, wherein the carboxylic acid ester moiety is palmitoleate and arachidate in a 1: 2 molar ratio; Octaesters of raffinose, wherein the carboxylic acid ester moiety is linoleate and behenate in a 1: 3 molar ratio; Heptaester of maltose wherein the esterified carboxylic acid moiety is a 3: 4 molar ratio of sunflower seed oil fatty acid and lignocerate; Octaesters of sucrose in which the esterified carboxylic acid moiety is a 2: 6 molar ratio of oleate and behenate; And octaesters of sucrose wherein the esterified carboxylic acid moiety is a 1: 3: 4 molar ratio of laurate, linoleate and behenate. Preferred solid materials are sucrose polyesters having a degree of esterification of 7 to 8 and C18 mono- and / or di-unsaturated and behenic fatty acids having molar ratios of 1: 7 to 3: 5 of the unsaturated: behenic moiety. Particularly preferred solid sugar polyesters are octaesters of sucrose with about 7 behenic fatty acid moieties and about 1 oleic acid moiety present in the molecule. Other materials include cottonseed or soybean oil fatty acid esters of sucrose. Such ester materials are described in US Pat. No. 2,831,854, US Pat. No. 4,005,196 (Jandacek, issued Jan. 25, 1977), each of which is incorporated herein by reference in its entirety; U.S. Patent 4,005,195 (Jandacek, issued Jan. 25, 1977); U.S. Patent 5,306,516 (Letton et al., April 26, 1994); U.S. Patent No. 5,306,515 to Letton et al., Issued April 26, 1994; US Patent No. 5,305,514 to Letton et al., Issued April 26, 1994; U.S. Patent 4,797,300 (Jandacek et al., Issued January 10, 1989); US Patent No. 3,963,699 (Rizzi et al., Issued June 15, 1976); U.S. Patent 4,518,772 (Volpenhein, issued May 21, 1985); And US Pat. No. 4,517,360 (Volpenhein, issued May 21, 1985).

Nonvolatile silicones such as polydialkylsiloxanes, polydiarylsiloxanes, and polyalkoxysiloxanes are also useful oils. These silicones are described in US Pat. No. 5,069,897 (Orr, issued Dec. 3, 1991), which is incorporated herein by reference in its entirety. The polyalkylsiloxanes correspond to the general formula R ₃ SiO [R ₂ SiO] _x SiR ₃ (wherein R is an alkyl group (preferably R is methyl or ethyl, more preferably methyl) and x is the desired molecular weight Is an integer of about 500 or less chosen to achieve). Commercially available polyalkylsiloxanes include polydimethylsiloxanes, also known as dimethicones; Non-limiting example of this is Vicasil Series (sold by General Electric Company), and Dow Corning 200 series (Dow Corning Corporation sold). Specific examples of polydimethylsiloxanes useful herein include Dow Corning having a viscosity of 10 centistokes and a boiling point above 200 ° C. 225 fluids and Dow Corning with viscosities of 50,350, and 12,500 centistokes and boiling points above 200 ° C., respectively. 200 fluids are included. Further, a polymerizable material corresponding to the general formula [(CH ₂ ) ₃ SiO _1/2 ] _x [SiO ₂ ] _y , wherein x is an integer from about 1 to about 500, and y is from about 1 to about 500 Also useful are substances such as trimethylsiloxysilicate, which is an integer. Commercially available trimethylsiloxysilicates are prepared from Dow Corning, a mixture with dimethicone. It is sold as 593 fluid. Dimethiconol, which is a hydroxy terminated dimethyl silicone, is also useful here. These materials may be represented by the general formulas R ₃ SiO [R ₂ SiO] _x SiR ₂ OH and HOR ₂ SiO [R ₂ SiO] _x SiR ₂ OH (wherein R is an alkyl group (preferably R is methyl or Ethyl, more preferably methyl), and x is an integer of about 500 or less selected to achieve the desired molecular weight). Commercial dimethiconols are typically sold as a mixture with dimethicone or cyclomethicone (eg, Dow Corning 1401, 1402, and 1403 fluid). Polyalkylaryl siloxanes are also useful herein, with polymethylphenyl siloxanes having a viscosity of about 15 to about 65 centistokes at 25 ° C. These materials are available, for example, as SF 1075 methylphenyl fluids sold by General Electric Company and 556 cosmetic grade phenyl trimethicone fluids sold by Dow Corning Corporation. Alkylated silicones such as methyldecyl silicone and methyloctyl silicone are also useful here and are commercially available from General Electric Company. Also useful are alkyl modified siloxanes, such as alkyl methicones and alkyl dimethicones, wherein the alkyl chains contain 10 to 50 carbons. Such siloxanes are sold under the trade names ABIL WAX 9810 (C ₂₄ -C ₂₈ alkyl methicone) sold by Goldschmidt and SF1632 (cetearyl methicone sold by General Electric Company).

Vegetable oils and hydrogenated vegetable oils are also useful here. Examples of vegetable oils and hydrogenated vegetable oils include safflower oil, castor oil, coconut oil, cottonseed oil, menhaden oil, palm seed oil, palm oil, peanut oil, soybean oil, rapeseed oil, flaxseed oil, rice bran oil. , Pine oil, sesame oil, sunflower seed oil, hydrogenated safflower oil, hydrogenated castor oil, hydrogenated coconut oil, hydrogenated cottonseed oil, hydrogenated menheiden oil, hydrogenated palm seed oil, hydrogenated palm oil, hydrogenated peanut oil, hydrogenated soybean oil, hydrogenated rapeseed oil, Hydrogenated flaxseed oil, hydrogenated rice bran oil, hydrogenated sesame oil, hydrogenated sunflower seed oil, and mixtures thereof.

Also useful here are C 4 -C 20 alkyl ethers of polypropylene glycol, C 1 -C 20 carboxylic acid esters of polypropylene glycol, and di-C 8 -C 30 alkyl ethers. Non-limiting examples of these materials include PPG-14 butyl ether, PPG-15 stearyl ether, dioctyl ether, dodecyl octyl ether, and mixtures thereof.

Hydrophobic chelating agents are also useful herein as hydrophobic conditioning agents. Suitable materials are described in US Pat. No. 4,387,244 (Scanlon et al., June 7, 1983), and co-pending US patent applications Ser. Nos. 09 / 258,747 and 09 / 259,485 (February 26, 1999 Schwartz et al. Filed under the name of.

Hydrophilic Conditioning Agent

Articles of the invention may optionally contain one or more hydrophilic conditioning agents. Non-limiting examples of hydrophilic conditioning agents include polyhydric alcohols, polypropylene glycols, polyethylene glycols, ureas, pyrrolidone carboxylic acids, ethoxylated and / or propoxylated C3 to C6 diols and triols, alpha-hydroxy C2 to C6 carboxylic acids, ethoxylated and / or propoxylated sugars, polyacrylic acid copolymers, sugars having up to about 12 carbon atoms, sugar alcohols up to about 12 carbon atoms, and mixtures thereof. Specific examples of useful hydrophilic conditioning agents include urea; Guanidine; Glycolic acid and glycolate salts (eg, ammonium and quaternary alkyl ammonium); Lactic acid and lactate salts (eg, ammonium and quaternary alkyl ammonium); Sucrose, fructose, glucose, erutrose, erythritol, sorbitol, mannitol, glycerol, hexanetriol, propylene glycol, butylene glycol, hexylene glycol and the like; Polyethylene glycols such as PEG-2, PEG-3, PEG-30, PEG-50, PPG-9, PPG-12, PPG-15, PPG-17, PPG-20, PPG-26, PPG-30, PPG- Polypropylene glycol such as 34; Alkoxylated glucose; Hyaluronic acid; Cationic skin conditioning polymers (eg, quaternary ammonium polymers such as polyquaternium polymers); And materials such as mixtures thereof. In particular, glycerol is the preferred hydrophilic conditioning agent in the articles of the present invention. In addition, various forms of aloe vera (eg, aloe vera gel), chitosan and chitosan derivatives such as chitosan lactate, lactamide monoethanolamine; Acetamide monoethanolamine; And materials such as mixtures thereof are also useful. Propoxylated glycerol as described in propoxylated glycerol described in US Pat. No. 4,976,953 (Orr et al., Dec. 11, 1990), which is incorporated herein by reference in its entirety.

The absence of therapeutic efficacy can be made in a variety of forms. In one embodiment of the invention, the absence of therapeutic efficacy is in the form of an emulsion. For example, oil-in-water, oil-in-oil, oil-in-oil, and oil-in-oil emulsions are useful here. As used in connection with emulsions, "water" can refer to water as well as water-soluble or water miscible materials such as glycerin.

Preferred absences of therapeutic efficacy include emulsions further comprising an aqueous phase and an oil phase. As will be understood by one skilled in the art, a given member will be distributed primarily in the water phase or oil phase depending on the water solubility / dispersibility of the therapeutic agonist in the absence. In one embodiment, the oil phase contains at least one hydrophobic conditioning agent. In another embodiment, the aqueous phase contains one or more hydrophilic conditioning agents.

The therapeutically potent members of the present invention, in emulsion form, generally contain an aqueous phase and an oily or lipidic phase. Suitable oils or lipids may be derived from animals, plants or petroleum and may be natural or synthetic (ie artificial). Such oils are those discussed in the hydrophobic conditioning agent section above. Suitable waterborne members include the hydrophilic conditioning agents discussed above. Preferred emulsion forms include aqueous emulsions in oils, aqueous emulsions in silicones, and other reverse phase emulsions. In addition, preferred emulsions also contain hydrophilic conditioning agents, such as glycerin, which allow the production of glycerin-type emulsions in oil.

In the emulsion form, the absence of therapeutic efficacy will preferably further contain from about 1% to about 10% by weight, more preferably from about 2% to about 5% by weight of the emulsifier relative to the absence of therapeutic efficacy. . The emulsifier may be nonionic, anionic or cationic. Suitable emulsifications are described, for example, in US Pat. No. 3,755,560 (Dickert et al., Aug. 28, 1973); U.S. Patent 4,421,769 (Dixon et al., Issued December 20, 1983); And McCutcheon's Detergents and Emulsifiers , North American Edition, p. 317-324 (1986). In addition, the absence of therapeutic efficacy in the form of emulsions may contain antifoams to minimize foaming upon application to the skin. Defoamers include high molecular weight silicone and other materials well known in the art for such use.

The absence of therapeutic efficacy may also be in the form of microemulsions. As used herein, "microemulsion" refers to a thermodynamically stable mixture of two immiscible solvents (one apolar and the other polar) stabilized by a surfactant which is an amphiphilic molecule. Preferred microemulsions include aqueous microemulsions in oil.

Vitamin compounds

Articles of the present invention may contain vitamin compounds, precursors, and derivatives thereof. These vitamin compounds may be in natural or synthetic form. Suitable vitamin compounds include vitamin A (eg, beta carotene, retinoic acid, retinol, retinoid, retinyl palmitate, retinyl propionate, etc.), vitamin B (eg, niacin, niacinamide, riboflavin, pantothenic acid, etc.), vitamins C (eg, ascorbic acid, etc.), vitamin D (eg, ergosterol, ergocalciferol, cholecalciferol, etc.), vitamin E (eg, tocopherol acetate, etc.), and vitamin K (eg, phytonadione, mena Diones, pthiocols, etc.) compounds, including but not limited to.

In particular, articles of the present invention may contain a safe effective amount of a vitamin B ₃ compound. The vitamin B ₃ compound is co-pending US application Ser. No. 08 / 834,010 (1997), which is incorporated herein by reference in its entirety. It is particularly useful for regulating skin conditions, as described in the application filed on Apr. 11, 2011) (corresponding to WO 97/39733 A1 published October 30, 1997). The therapeutic member of the present invention is preferably about 0.01% to about 50%, more preferably about 0.1% to about 10%, even more preferably about 0.5% to about 10%, even more preferably about 1% To about 5%, most preferably about 2% to about 5% of a vitamin B ₃ compound.

As used herein, a "vitamin B ₃ compound" is a compound having the formula: Derivatives thereof; And salts of any of the foregoing:

Wherein R is -CONH ₂ (ie niacinamide), -COOH (ie nicotinic acid) or -CH ₂ OH (ie nicotinyl alcohol).

Examples of the above-mentioned derivatives of the vitamin B ₃ compound include nicotinic acid esters including non-vascular expanding esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxides and niacinamide N-oxides. .

Examples of suitable vitamin B ₃ compounds are well known in the art and include a number of sources such as Sigma Chemical Company (St. Louis, MO); Commercially available from ICN Biomedicals, Inc. (Irvin, CA) and Aldrich Chemical Company (Milwaukee, WI)

Vitamin compounds may be included as substantially pure substances or as extracts obtained by suitable physical and / or chemical isolation from natural sources (eg, plants).

Skin treatments

Articles of the invention may contain one or more skin treatments. Suitable skin treatments include those effective for the prevention, delay, arrest, and / or reversal of skin wrinkles. Examples of suitable skin treatments include, but are not limited to, alpha-hydroxy acids such as lactic acid and glycolic acid and beta-hydroxy acids such as salicylic acid.

Antiacne medication

Examples of anti-acne agents useful in the articles of the present invention include keratinizing agents such as salicylic acid (o-hydroxybenzoic acid), derivatives of salicylic acid such as 5-octanoyl salicylic acid, and resorcinol; Retinoids such as retinoic acid and derivatives thereof (eg cis and trans); Sulfur-containing D and L amino acids and derivatives and salts thereof, in particular N-acetyl derivatives thereof, preferred examples being N-acetyl-L-cysteine; Lipoic acid; Antibiotics and antibacterial agents such as benzoyl peroxide, octopirox, tetracycline, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'-trichlorovanylide, Azelaic acid and derivatives thereof, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, ethyl acetate, clindamycin and meclocycline; Sebostats such as flavonoids; And bile salts such as scynmnol sulfate and derivatives thereof, deoxycholate, and cholate.

Anti Wrinkle and Skin Atrophy

Examples of antiwrinkle and anti-skin atrophy agents useful in the articles of the invention include retinoic acid and derivatives thereof (eg, cis and trans); Retinol; Retinyl esters; Niacinamide, salicylic acid and derivatives thereof; Sulfur containing D and L amino acids and derivatives and salts thereof, in particular N-acetyl derivatives, as preferred examples thereof, N-acetyl-L-cysteine; Thiols such as ethane thiol; Hydroxy acid, phytic acid, lipoic acid; Lysophosphatidic acid, and skin dermabrasions (eg, phenol, etc.).

NSAIDs

Examples of NSAIDS useful in the articles of the invention include, but are not limited to, the following categories: propionic acid derivatives; Acetic acid derivatives; Phenoic acid derivatives; Biphenylcarboxylic acid derivatives; And oxycam. All of these NSAIDS are fully described in US Pat. No. 4,985,459 (Sunshine et al., Issued January 15, 1991), which is incorporated herein by reference in its entirety. Examples of useful NSAIDS are acetyl salicylic acid, ibuprofen, naproxen, benoxapropene, flurbiprofen, phenofene, fenbufen, ketoprofen, indoprofen, pirprofen, carpropene, oxaprozin , Pranopropene, miroprofen, thioxapropene, supropene, aminopropene, thiapropenic acid, flupropene and bucloxic acid. Also useful are steroidal anti-inflammatory drugs, including hydrocortisone and the like.

Local anesthetics

Examples of topical anesthetics useful in the articles herein include benzocaine, lidocaine, bupivacaine, chlorprocaine, dibucaine, ethidocaine, mepivacaine, tetracaine, diclonin, hexylcaine, procaine, cocaine, Ketamine, pramoxin, phenol, and pharmaceutically acceptable salts thereof.

Artificial tanning agents and tanning accelerators

Examples of artificial tanning agents and tanning accelerators useful in the articles of the present invention include, but are not limited to, dihydroxyacetaone, tyrosine, tyrosine esters such as ethyl tyrosinate, and phospho-DOPA.

Antibacterial and Antifungal Agents

Examples of antibacterial and antifungal agents useful in the articles of the invention include β-lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4'-trichloro-2'-hydride Oxydiphenyl ether, 3,4,4'-trichlorocarbanilide, phenoxyethanol, phenoxy propanol, phenoxyisopropanol, doxycycline, capremycin, chlorhexidine, chlortetracycline, oxytetracycline, clindamycin, ethambutol, Hexamidine, isethionate, metronidazole, pentamidine, gentamicin, kanamycin, linenemycin, metacycline, metheneamine, minocycline, neomycin, netylmycin, paromomycin, streptomycin, tobramycin, myconazole, tetra Cyclin Hydrochloride, Erythromycin, Zinc Erythromycin, Erythromycin Estoleate, Erythromycin Arate, Amikacin Sulfate, Doxycycline Hydrochloride, Capreomycin Sulfate, Chlorhexidine Gluconate, Chlorhexidine Hydrochloride, Chlortetracycline Hydrochloride, Oxytetracycline Hydrochloride, Clindamycin Hydrochloride, Etambutol Hydrochloride, Metronidazole Hydrochloride , Pentamidine hydrochloride, gentamicin sulfate, kanamycin sulfate, linenemycin hydrochloride, metacycline hydrochloride, metheneamine hypofulate, metheneamine mandelate, minocycline hydrochloride, neomycin sulfate, netylmycin sulfate , Paromomycin sulfate, streptomycin sulfate, tobramycin sulfate, myconazole hydrochloride, amanfadine hydrochloride, amanpadin sulfate , Octopyrox, parachlorometa xylenol, nystatin, tolnaftate, zinc pyrithione and clotrimazole.

Antiviral agents

The article of the present invention may further contain one or more antiviral agents. Suitable antiviral agents include, but are not limited to, metal salts (eg, silver nitrate, copper sulfate, iron chloride, and the like), and organic acids (eg, malic acid, salicylic acid, succinic acid, benzoic acid, and the like). In particular, compositions containing additional suitable antiviral agents include, but are not limited to, co-pending US patent application Ser. No. 09 / 421,084 (Beerse et al.), Filed October 19, 1999; 09 / 421,131 (Biedermann et al.); 09 / 420,646 to Morgan et al .; And 09 / 421,179 (Page et al.).

enzyme

Articles of the invention may optionally comprise one or more enzymes. Preferably, such enzymes are dermatologically acceptable. Suitable enzymes include, but are not limited to, keratinase, protease, amylase, subtilisin, and the like.

Sunscreen

Sunscreens are also useful here. A wide variety of sunscreen agents are disclosed in US Pat. No. 5,087,445 to Haffey et al., Feb. 11, 1992, all of which are incorporated herein by reference in their entirety; US Patent No. 5,073,372 (Turner et al., Issued Dec. 17, 1991); US Patent No. 5,073,371 (Turner et al., Issued Dec. 17, 1991); And Segarin et al., Cosmetics Science and Technology, Chapter VIII, p. 189 and below. Non-limiting examples of sunscreens useful in the compositions of the present invention include 2-ethylhexyl p -methoxycinnamate, 2-ethylhexyl N, N-dimethyl- p -aminobenzoate, p -aminobenzoic acid, 2-phenylbenz Imidazole-5-sulfonic acid, octocrylene, oxybenzone, homomentyl salicylate, octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, 4-isopropyl dibenzoylmethane, 3- Benzylidene camphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof. Other useful sunscreens include US Pat. No. 4,937,370 (Sabatelli, issued June 26, 1990); And US Pat. No. 4,999,186 to Sabatelli et al., Issued March 12, 1991, both of which are incorporated herein by reference in their entirety. Particularly preferred examples of such sunscreens include 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, 4-N, N- (4-hydroxydibenzoylmethane) 2-ethylhexyl) methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) -methylaminobenzoic acid ester of 2-hydroxy-4- (2-hydroxyethoxy) benzophenone, 4- (2 4-N, N- (2-ethylhexyl) -methylaminobenzoic acid ester of -hydroxyethoxy) dibenzoylmethane, and mixtures thereof. The exact amount of sunscreen that can be used will depend on the sunscreen chosen and the desired sunscreen index (SPF) to be achieved. SPF is a commonly used measure of sunscreen protection against erythema. The Federal Register , Vol. 43, No. 166, pp. 38206-38269, August 25, 1978].

Hydrocolloid

Hydrocolloids may also optionally be included in the articles of the present invention. Hydrocolloids are known in the art and assist in extending the useful life of the surfactant contained in the cleansing members of the present invention, allowing the article to last through one or more entire showers or baths. Suitable hydrocolloids include xanthan gum, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxylpropyl cellulose, methyl and ethyl cellulose, natural rubbers, gudras guar gum, soybean rubber, natural starch, deionized starch ( Starch octenyl succinate) and the like, but is not limited thereto.

Pyrogenic zeolite

Zeolites and other compounds, which exothermic when combined with water, may also optionally be included in the articles of the present invention.

Structured conditioning agents

Articles of the present invention may optionally contain structured conditioning agents. Suitable structured conditioning agents include, but are not limited to, vesicular structures such as ceramides, liposomes, and the like.

Hydrogel-forming Polymeric Gelling Agent

In certain embodiments of the invention, the article may optionally contain an hydrogel forming polymeric gelling agent and an aqueous gel formed from water, ie, a "hydrogel". More specifically, the hydrogel is contained within the cleansing absence or the therapeutic efficacy of the article. In the presence of an aqueous gel, the article is preferably from about 0.1% to about 100%, more preferably from about 3% to about 50%, most preferably from about 5% to about 5% by weight relative to the water insoluble substrate 35 wt% of the hydrogel forming polymeric gelling agent calculated based on the dry weight of the hydrogel forming polymeric gelling agent.

In general, the hydrogel forming polymeric gelling agent material of the present invention is at least partially crosslinked polymer made from polymerizable unsaturated acid containing monomers that are water soluble or water soluble upon hydrolysis. This includes monoethylenically unsaturated compounds having one or more hydrophilic radicals, including but not limited to olefinically unsaturated acids and anhydrides comprising one or more carbon-carbon olefinic double bonds. For these monomers, water soluble means that the monomer is dissolved in deionized water at a level of at least 0.2%, preferably at least 1.0% at 25 ° C.

In the polymerization, the monomeric units as mentioned above are generally from about 25 mol% to 99.99 mol%, more preferably from about 50 mol% to 99.99 mol%, most preferably at least about 75 mol% of the polymeric gelling agent material. Phosphorus (based on the dry weight of the polymer), acid-containing monomers.

The hydrogel forming polymeric gelling agent here is preferably partially crosslinked to a high enough degree so that the resulting polymer does not exhibit a glass transition temperature (Tg) of less than about 140 ° C., and therefore the same terms as used herein. "Hydrogel forming polymeric gelling agent" shall mean a polymer that meets these parameters. Preferably, the hydrogel forming polymeric gelling agent has no Tg below about 180 ° C., more preferably no Tg at temperatures above about 300 ° C. prior to degradation of the polymer. The Tg can be measured by differential scanning calorimetry (DSC) performed at a heating rate of 20.0 ° C./minute using a sample of 5 mg or less. Tg is calculated as the midpoint between the start point and the end point of the heat flow change corresponding to the glass transition on the DSC heat capacity heating curve. The use of DSC to measure Tg is well known in the art, see [B. Cassel and MP DiVito, "Use of DSC To Obtain Accurate Thermodynamic and Kinetic Data", American Laboratory, January 1994, pp 14-19, and [B. Wunderlich, Thermal Analysis , Academic Press, Inc., 1990.

Hydrogel-forming polymeric materials are characterized as highly absorbent and may retain water in the absorbed or “gel” state. Preferred hydrogel forming polymeric gelling agents herein can absorb at least about 40 g, preferably at least about 60 g / g, more preferably at least about 80 g / g of water (deionized water) per gram of gelling agent. There will be. Such values, referred to herein as "absorption capacities", can be measured according to the procedures in the absorption capacities "teabag" test described above.

The hydrogel forming polymeric gelling agent will generally be at least partially crosslinked. Suitable crosslinkers are well known in the art and include, for example, (1) compounds having two or more polymerizable double bonds; (2) compounds having at least one polymerizable double bond and at least one functional group reactive with an acid containing monomer material; (3) compounds having at least two functional groups reactive with acid-containing monomer materials; And (4) a polyvalent metal compound capable of forming an ionic crosslinking portion.

Crosslinking agents having two or more polymerizable double bonds include (i) di- or polyvinyl compounds such as divinylbenzene and divinyltoluene; (ii) di- or polyesters of polyols and unsaturated mono- or polycarboxylic acids, including, for example, di- or triacrylic acid esters of polyols such as ethylene glycol, trimethylol propane, glycerin, or polyoxyethylene glycol ; (iii) bisacrylamides such as N, N-methylenebisacrylamide; (iv) carbamyl esters obtainable by reacting polyisocyanates with hydroxyl group containing monomers; (v) di- or polyallyl ethers of polyols; (vi) di- or polyallyl esters of polycarboxylic acids such as diallyl phthalate, diallyl adipate and the like; (vii) monoallyl esters of polyols and esters of unsaturated mono- or polycarboxylic acids, such as acrylic acid esters of polyethylene glycol monoallyl ethers; And (viii) di- or triallyl amines.

Crosslinking agents having at least one polymerizable double bond and at least one functional group reactive with an acid containing monomeric material include N-methylol acrylamide, glycidyl acrylate and the like. Suitable crosslinkers having two or more functional groups reactive with acid containing monomer materials include glyoxal; Polyols such as ethylene glycol and glycerol; Polyamines such as alkylene diamines (eg ethylene diamine), polyalkylene polyamines, polyepoxides, di- or polyglycidyl ethers and the like. Suitable multivalent metal crosslinkers capable of forming ionic crosslinks include, for example, oxides, hydroxides and weak acid salts of alkaline earth metals (eg calcium, magnesium) and zinc, including calcium oxide and zinc diacetate (eg , Carbonates, acetates, and the like).

Many of the aforementioned types of crosslinkers are described in more detail in US Pat. No. 4,076,663 (Masuda et al., Feb. 28, 1978), and US Pat. No. 4,861,539 (Allen et al., Aug. 29, 1989). , Both of which are incorporated herein by reference. Preferred crosslinkers include di- or polyesters, bisacrylamides, and di- or triallyl amines of unsaturated mono- or polycarboxylic monoallyl esters of polyols. Specific examples of particularly preferred crosslinking agents include N, N'-methylenebisacrylamide and trimethylol propane triacrylate.

The crosslinker will generally comprise from about 0.001 mole percent to 5 mole percent of the resulting hydrogel forming polymeric material. More generally, the crosslinker will comprise from about 0.01 mole percent to 3 mole percent of the hydrogel forming polymeric gelling agent used herein.

The hydrogel forming polymeric gelling agents can be used here in partially neutralized form. For the purposes of the present invention, such materials are considered partially neutralized when at least 25 mol%, preferably at least 50 mol%, of the monomers used to form the polymer are acid group containing monomers neutralized with a base. Suitable base cations for neutralization include hydroxides of alkali and alkaline earth metals (eg KOH, NaOH), ammonium, substituted ammonium, and amino alcohols (eg 2-amino-2-methyl-1,3-propanediol, diethanol Amines, and amines such as 2-amino-2-methyl-1-propanol). The above percentage of total monomers used which are neutralized acid group containing monomers is referred to herein as "degree of neutralization". The degree of neutralization will preferably not exceed 98%.

Hydrogel forming polymeric gelling agents suitable for use herein are well known in the art and are described, for example, in US Pat. No. 4,076,663 (Masuda et al., Feb. 28, 1978); U.S. Patent 4,062,817 (Westerman, issued Dec. 13, 1977); U.S. Patent 4,286,082 (Tsubakimoto et al., Issued August 25, 1981); US Patent No. 5,061,259 (Goldman et al., Issued October 29, 1991); And US Pat. No. 4,654,039 (Brandt et al., Issued March 31, 1987), each of which is incorporated herein by reference in its entirety.

Hydrogel forming polymeric gelling agents suitable for use herein are also described in US Pat. No. 4,731,067 (Le-Khac, issued March 15, 1988), US Pat. No. 4,743,244 (Le-Khac, May 10, 1988). ), US Patent No. 4,813,945 (Le-Khac, issued March 21, 1989), US Patent No. 4,880,868 (Le-Khac, issued November 14, 1989), US Patent No. 4,892,533 (Le-Khac, Issued January 9, 1990), US Pat. No. 5,026,784 (Le-Khac, issued June 25, 1991), US Pat. No. 5,079,306 (Le-Khac, issued January 7, 1992), US Pat. 5,151,465 (Le-Khac, issued September 29, 1992), US Pat. Nos. 4,861,539 (Allen, Farrer, and Flesher, issued August 29, 1989), and US Pat. No. 4,962,172 (Allen, Farrer, and Flesher, issued October 9, 1990, each of which is incorporated herein by reference in their entirety.

Suitable hydrogel-forming polymeric gelling agents in particle form include Hoechst Celanese Corporation (Portsmouth, VA, USA) (Sanwet ^™ superabsorbent polymer), Nippon Shokubai, (Japan) (Aqualic ^™ such as L-75, L-76), And Dow Chemical Company (Midland, MI, USA) (Dry Tech ^™ ).

Hydrogel-forming polymeric gelling agents in fiber form are commercially available from Camelot Technologies Inc. (Leominster, MA, USA) (Fibersorb ^™ such as SA 7200H, SA 7200M, SA 7000L, SA 7000, and SA 7300).

Articles of the invention may also contain other hydrophilic gelling agents. These include relatively low degree of crosslinking and carboxylic acid containing polymers as described above, except for those having a Tg of less than 140 ° C., as well as various other water soluble or colloidal water soluble polymers such as cellulose ethers (eg hydroxyethyl cellulose, methyl cellulose, Hydroxypropylmethyl cellulose), polyvinylpyrrolidone, polyvinylalcohol, guar rubber, hydroxypropyl guar rubber and xanthan rubber. Preferred among these additional hydrophilic gelling agents are acid containing polymers, in particular carboxylic acid containing polymers. Particular preference is given to water soluble polymers of acrylic acid crosslinked with polyalkenyl polyethers of polyhydric alcohols, and optionally acrylate esters or polyfunctional vinylidene monomers.

Preferred copolymers useful in the present invention include 95% to 99% by weight of an olefinically unsaturated carboxyl monomer selected from the group consisting of acrylic acid, methacrylic acid and ethacrylic acid; From about 1% to about 3.5% by weight of acrylate ester of the formula:

(Wherein R is an alkyl radical having 10 to 30 carbon atoms and R ₁ is hydrogen, methyl or ethyl); And 0.1 to 0.6 weight percent of a polymerizable crosslinked polyalkenyl polyether of a polyhydric alcohol containing more than one alkenyl ether group per molecule (the parent polyhydric alcohol contains three or more carbon atoms and three or more hydroxyl groups). It is the polymer of the monomer mixture containing in weight%.

Preferably, these polymers contain from about 96% to about 97.9% by weight acrylic acid and from about 2.5% to about 3.5% by weight acrylic acid ester, wherein the alkyl group has 12 to 22 carbon atoms and R ₁ is methyl And most preferably, the acrylate ester is stearyl methacrylate. Preferably, the amount of crosslinked polyalkenyl polyether monomer is about 0.2% to 0.4% by weight. Preferred crosslinked polyalkenyl polyether monomers are allyl pentaerythritol, trimethylolpropane diallylether or allyl sucrose. These polymers are fully described in US Pat. No. 4,509,949, issued by Huang et al., April 5, 1985, which is incorporated herein by reference.

Another preferred copolymer useful in the present invention is a polymer containing two or more monomeric components, one of which is a monomeric olefinically unsaturated carboxylic acid and the other of which is a polyalkenyl polyether of a polyhydric alcohol. If desired, additional monomeric materials may be present in the monomeric mixture, even in predominant proportions.

The first monomeric component useful for producing the carboxyl polymer is an olefinically unsaturated carboxylic acid containing at least one activated carbon-carbon olefinic double bond, and at least one carboxyl group. Preferred carboxyl monomers are acrylic acids having the general structure:

Wherein R ² is a substituent selected from the group consisting of hydrogen, halogen, and cyanogen (—C═N) groups, monovalent alkyl radicals, monovalent alkali radicals and monovalent cycloaliphatic radicals). Among the classes, acrylic acid, methacrylic acid, and ethacrylic acid are most preferred. Another useful carboxyl monomer is maleic anhydride or maleic acid. The amount of acid used will be about 95.5 wt% to about 98.9 wt%.

Secondary monomeric components useful in the production of these carboxyl polymers have more than one alkenyl ether group per molecule, such as alkenyl groups in which olefinic double bonds are attached to terminal methylene groups CH ₂ = C <. Polyalkenyl polyethers.

Additional monomeric materials that may be present in the polymer include, for example, polyfunctional vinylidene containing two or more terminal CH ₂ <groups, including butadiene, isoprene, divinyl benzene, divinyl naphthylene, allyl acrylate, and the like. Monomers are included. Such polymers are fully described in US Pat. No. 2,798,053 (Brown, issued July 2, 1957), which is incorporated herein by reference in its entirety.

Examples of carboxylic acid copolymers useful in the present invention include Carbomer 934, Carbomer 941, Carbomer 950, Carbomer 951, Carbomer 954, Carbomer 980, Carbomer 981, Carbomer 1342, Acrylate / C10-30 Alkyl acrylate cross polymers (Carbopol 934, Carbopol 941, Carbopol 950, Carbopol 951, Carbopol 954, Carbopol 980, Carbopol 981, Carbopol 1342, and Pemulen series, each available from BF Goodrich).

Other carboxylic acid copolymers useful in the present invention include the sodium salts of acrylic acid / acrylamide copolymers sold under the trade name Hostaceren PN73 by Hoechst Celanese Corporation. Also included are hydrogel polymers sold under the trade name HYPAN hydrogel by Lipo Chemicals Inc. These hydrogels consist of crystalline flicks of nitrate on the C-C backbone with various other pendant groups such as carboxyl, amide, and amidine. Examples thereof will include HYPAN SA 100 H, a polymer powder commercially available from Lipo Chemical.

Neutralizers used to neutralize the acid groups of these polymers include those described above.

Cleansing parts

The article of the present invention may optionally contain a cleansing member further containing one or more surfactants. The cleansing member is disposed adjacent to the nonwoven layer of the water insoluble substrate. The article of the present invention comprises a surfactant at about 10% to about 1,000%, preferably from about 50% to about 600%, more preferably from about 100% to about 250% by weight relative to the water-insoluble substrate It contains. In addition, the articles of the invention preferably contain at least about 1 g of surfactant based on the weight of the water-insoluble substrate. Thus, the cleansing member can be added to the substrate without requiring a drying process.

The surfactant of the cleansing member is preferably a foaming surfactant. As used herein, “bubbling surfactant” means a surfactant that, when combined with water, produces a foam or foam when mechanically stirred. Since the increased foam is important for consumers as an indication of the cleansing effect, such surfactants are preferred. In certain embodiments, the surfactant or combination of surfactants is mild. As used herein, “mild” means a conventional rod soap matrix (eg, Lever 2000) in which not only surfactants but also articles of the invention contain at least a combination of natural soaps and synthetic surfactants. And Zest It means that the skin is gentler than). The method of measuring the mildness or vice versa of a surfactant containing article is based on the skin barrier destruction test. In this test, the milder the surfactant, the less disruptive the skin barrier is. Skin barrier destruction is measured by the relative amount of radiolabeled (tritium labeled) water (3H-H ₂ O) that flows from the test solution through the skin epidermis into the physiological buffer contained in the dialysate chamber. The test is described in TJ Franz, J. Invest. Dermatol. , 1975, 64, pp. 190-195; And US Pat. No. 4,673,525 (Small et al., June 16, 1987), both of which are incorporated herein by reference in their entirety. Other test methodologies for measuring the mildness of a surfactant, well known to those skilled in the art, can also be used.

A wide variety of foaming surfactants are useful herein and are selected from the group consisting of anionic foaming surfactants, nonionic foaming surfactants, cationic foaming surfactants, amphoteric foaming surfactants and mixtures thereof. It is included.

Anionic Foaming Surfactants

Non-limiting examples of anionic foaming surfactants useful in the compositions of the present invention are described in McCutcheon's, Detergents and Emulsifiers , North American edition (1986), Allured Publishing Corporation; McCutcheon's, Functional Materials , North American Edition (1992); And US Pat. No. 3,929,678 to Laughlin et al., Issued Dec. 30, 1975, each of which is incorporated herein by reference in its entirety.

A wide variety of anionic surfactants are potentially useful herein. Non-limiting examples of anionic foaming surfactants include alkyl and alkyl ether sulfates, sulfated monoglycerides, sulfonated olefins, alkyl aryl sulfonates, primary or secondary alkane sulfonates, alkyl sulfosuccinates, acyl taurates , Acyl isethionate, alkyl glyceryl ether sulfonate, sulfonated methyl ester, sulfonated fatty acid, alkyl phosphate, acyl glutamate, acyl sarcosinate, alkyl sulfoacetate, acylated peptide, alkyl ether carboxylate, acyl lactylate , Anionic fluorosurfactants, and combinations thereof. Combinations of anionic surfactants can be used effectively in the present invention.

Suitable anionic surfactants for use in the cleansing members include alkyl and alkyl ether sulfates. The materials each have the formula R ¹ O—SO ₃ M and R ¹ (CH ₂ H ₄ O) _x —O—SO ₃ M, wherein R ¹ is saturated or unsaturated, branched or unbranched, having from about 8 to about carbon atoms An alkyl group of 24, x is from 1 to 10, and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. Such alkyl sulphates are typically prepared by sulphating monohydric alcohols (about 8 to about 24 carbon atoms) using sulfur trioxide, or by other known sulphating techniques. Such alkyl ether sulfates are typically prepared by sulfated condensation products of ethylene oxide and monohydric alcohols (about 8 to about 24 carbon atoms). These alcohols may be derived from or synthesized from fats such as coconut oil or tallow. Specific examples of alkyl sulfates that can be used in the cleansing member are the sodium, ammonium, potassium, magnesium or TEA salts of lauryl or myristyl sulfate. Examples of alkyl ether sulfates that can be used include ammonium, sodium, magnesium, or TEA laureth-3 sulfate.

Another suitable class of anionic surfactants are sulfated monoglycerides in the form of R ¹ CO—O—CH ₂ —C (OH) H—CH ₂ —O—SO ₃ M, wherein R ¹ is saturated or Unsaturated, branched or unbranched alkyl group having about 8 to about 24 carbon atoms, M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine, and monoethanolamine. They are typically prepared by reaction of glycerin with fatty acids (about 8 to about 24 carbon atoms) to produce monoglycerides, which are then sulfated with sulfur trioxide. An example of sulfated monoglycerides is sodium cocomonoglyceride sulfate.

Other suitable anionic surfactants include olefin sulfonates in the form of R ¹ SO ₃ M, wherein R ¹ is a mono olefin having from about 12 to about 24 carbon atoms, M is ammonium, sodium, potassium, magnesium, triethanolamine, Water soluble cations such as diethanolamine and monoethanolamine. The compound is prepared by sulfonating the alpha olefin with un complexed sulfur trioxide, and then neutralizing the acid reaction mixture under conditions such that all of the sultones formed during the reaction are hydrolyzed to produce the corresponding hydroxyalkanesulfonate. Can be prepared. Examples of sulfonated olefins are sodium C14 / C16 alpha olefin sulfonates.

Other suitable anionic surfactants include linear alkylbenzene sulfonates in the form of R ¹ -C ₆ H ₄ -SO ₃ M, wherein R ¹ is a saturated or unsaturated, branched or unbranched alkyl group having from about 8 to about 24 carbon atoms. And M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. They are formed by sulfonating linear alkyl benzene with sulfur trioxide. Examples of such anionic surfactants are sodium dodecylbenzene sulfonate.

Other anionic surfactants suitable for cleansing members include primary or secondary alkane sulfonates in the form of R ¹ SO ₃ M, wherein R ¹ is saturated or unsaturated, branched or unbranched alkyl having about 8 to about 24 carbon atoms. And M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These are generally produced by sulfonation of paraffins using sulfur dioxide in the presence of chlorine and ultraviolet light or by other known sulfonation methods. The sulfonation can occur at the secondary or primary position of the alkyl chain. Examples of alkanesulfonates useful herein are alkali metal or ammonium C13 to C17 paraffin sulfonates.

Still other suitable anionic surfactants include alkyl sulfosuccinates, which include disodium N-octadecylsulfosuccinate; Diammonium lauryl sulfosuccinate; Tetrasodium N- (1,2-dicarboxyethyl) -N-octadecylsulfosuccinate; Diamyl ester of sodium sulfosuccinic acid; Dihexyl ester of sodium sulfosuccinic acid; And dioctyl esters of sodium sulfosuccinic acid.

Taurates based on taurine, also known as 2-aminoethanesulfonic acid, are also useful. Examples of taurates include N-alkyltaurines, such as those prepared by reacting dodecylamine with sodium isethionate, as described in detail in US Pat. No. 2,658,072, which is incorporated herein by reference in its entirety. Other examples based on taurine include acyl taurine formed by reacting n-methyl taurine with fatty acids (about 8 to about 24 carbon atoms).

Another class of anionic surfactants suitable for use in cleansing members is acyl isethionate. Said acyl isethionate typically has the formula R ¹ CO—O—CH ₂ CH ₂ SO ₃ M, wherein R ¹ is an alkyl group having from about 10 to about 30 carbon atoms that is saturated or unsaturated, branched or unbranched, and M is Cation. These are typically formed by reacting fatty acids (about 8 to about 30 carbon atoms) with alkali metal isethionates. Non-limiting examples of such acyl isethionates include ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate and mixtures thereof.

Another suitable anionic surfactant is alkylglyceryl ether sulfonate in the form of R ¹ -OCH ₂ -C (OH) H-CH ₂ -SO ₃ M, wherein R ¹ is saturated or unsaturated, branched or unbranched. Phosphorus is an alkyl group having from about 8 to about 24 carbon atoms, and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These can be formed by reacting epichlorohydrin and sodium bisulfite with fatty alcohols (about 8 to about 24 carbon atoms) or by other known methods. One example is sodium cocoglyceryl ether sulfonate.

Other suitable anionic surfactants include sulfonated fatty acids in the form of R ¹ -CH (SO ₄ ) -COOH and sulfonated methyl esters in the form of R ¹ -CH (SO ₄ ) -CO-O-CH ₃ , wherein R ¹ is an alkyl group having from about 8 to about 24 carbon atoms which is saturated or unsaturated, branched or unbranched. These may be formed by sulfonating fatty acids or alkyl methyl esters (about 8 to about 24 carbon atoms) with sulfur trioxide or by other known sulfonation techniques. Examples include alpha sulfonated coconut fatty acids and lauryl methyl esters.

Other anionic materials include phosphates such as monoalkyl, dialkyl, and trialkyl phosphate salts formed by reaction of phosphorus pentoxide with monohydric alcohols having about 8 to about 24 carbon atoms, branched or unbranched. They can also be formed by other known phosphate methods. Examples of this class of surfactants are sodium mono or dilaurylphosphate.

Other anionic materials include acyl glutamate corresponding to the formula R ¹ CO-N (COOH) -CH ₂ CH ₂ -CO ₂ M, wherein R ¹ is saturated or unsaturated, branched or unbranched, having from about 8 to about carbon atoms About 24 alkyl or alkenyl groups, and M is a water soluble cation. Non-limiting examples thereof include sodium lauroyl glutamate and sodium cocoyl glutamate.

Other anionic materials include alkanoyl sarcosinates corresponding to the formula R ¹ CON (CH ₃ ) —CH ₂ CH ₂ —CO ₂ M, wherein R ¹ is saturated or unsaturated, branched or unbranched, containing about carbon number 10 to about 20 alkyl or alkenyl groups, and M is a water soluble cation. Non-limiting examples thereof include sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, and ammonium lauroyl sarcosinate.

Other anionic materials include alkyl ether carboxylates corresponding to the formula R ^1- (OCH ₂ CH ₂ ) _x -OCH ₂ -CO ₂ M, wherein R ¹ is saturated or unsaturated, branched or unbranched carbon number About 8 to about 24 alkyl or alkenyl groups, x is 1 to 10, and M is a water soluble cation. Non-limiting examples thereof include sodium laureth carboxylate.

Other anionic materials include acyl lactylates corresponding to the formula R ¹ CO— [O—CH (CH ₃ ) —CO] _x —CO ₂ M, wherein R ¹ is saturated or unsaturated, branched or unbranched An alkyl or alkenyl group having from about 8 to about 24 carbon atoms, x is 3, and M is a water soluble cation. Non-limiting examples thereof include sodium cocoyl lactylate.

Other anionic materials include carboxylates, non-limiting examples of which include sodium lauroyl carboxylate, sodium cocoyl carboxylate, and ammonium lauroyl carboxylate. Anionic fluorosurfactants may also be used.

Other anionic materials include, by way of example, natural soaps derived from saponification of vegetable and / or animal fats and oils, including sodium laurate, sodium myristate, palmitate, stearate, tallowate, cocoate.

Any mating cation M can be used for the anionic surfactant. Preferably, the counter cation is selected from the group consisting of sodium, potassium, ammonium, monoethanolamine, diethanolamine, and triethanolamine. More preferably, the counter cation is ammonium.

Nonionic Foaming Surfactant

Non-limiting examples of nonionic foaming surfactants used in the compositions of the present invention include those published by McCutcheon's, Detergents and Emulsifiers , North American edition (1986), allured Publishing Corporation; And McCutcheon's Functional Materials , North American Edition (1992), all of which are incorporated herein by reference in their entirety.

Nonionic foaming surfactants useful herein include those selected from the group consisting of alkyl glucosides, alkyl polyglucosides, polyhydroxy fatty acid amides, alkoxylated fatty acid esters, sucrose esters, amine oxides, and mixtures thereof.

Alkyl glucosides and alkyl polyglucosides are useful here, and they are broadly condensed with long chain alcohols, such as C8-30 alcohols, with sugars or starches, or sugars or starch polymers, ie glycosides or polyglycosides. It can be defined as a product. The compound may be represented by the formula (S) _n- OR, wherein S is a sugar moiety such as glucose, fructose, mannose, and galactose; n is an integer of about 1 to about 1000, and R is an alkyl group of C8-30. Examples of long chain alcohols from which the alkyl group can be derived include decyl alcohol, cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol and the like. Preferred examples of such surfactants include those in which S is a glucose moiety, R is a C8-20 alkyl group, and n is an integer from about 1 to about 9. Examples of such commercially available surfactants include decyl polyglucoside (commercially available from Henkel as APG 325 CS) and lauryl polyglucoside (commercially available from Henkel as APG 600 CS and 625 CS). Sucrose ester surfactants such as sucrose cocoate and sucrose laurate are also useful.

Other useful nonionic surfactants include polyhydroxy fatty acid amide surfactants, and more specific examples include glucosamide corresponding to the following chemical structure:

Wherein R ¹ is H, C ₁ -C ₄ alkyl, 2-hydroxyethyl, 2-hydroxy-propyl, preferably C ₁ -C ₄ alkyl, more preferably methyl or ethyl, most preferably Is methyl; R ² is C ₅ to C ₃₁ alkyl or alkenyl, preferably C ₇ to C ₁₉ alkyl or alkenyl, more preferably C ₉ to C ₁₇ alkyl or alkenyl, most preferably C ₁₁ ˜C ₁₅ alkyl or alkenyl; Z is a polyhydroxyhydrocarbyl moiety having a linear hydrocarbyl chain having three or more hydroxyls directly linked to the chain, or an alkoxylation thereof (preferably ethoxylated or propoxy) Is a derivative). Z is preferably a sugar moiety selected from the group consisting of glucose, fructose, maltose, lactose, galactose, mannose, xylose and mixtures thereof. Particularly preferred surfactants corresponding to this structure are coconut alkyl N-methyl glucoside amides (ie, wherein the R ² CO- moiety is derived from coconut oil fatty acids). Methods of preparing compositions containing polyhydroxy fatty acid amides are described, for example, in British Patent Specification No. 809,060 (published February 18, 1959, Thomas Hedley & Co., Ltd.); US Patent No. 2,965,576 (ER Wilson, issued December 20, 1960); US Patent No. 2,703,798 (AM Schwartz, issued March 8, 1955); And US Pat. No. 1,985,424 (Piggott, issued Dec. 25, 1934); Each of which is incorporated herein by reference in its entirety.

Other examples of nonionic surfactants include amine oxides. The amine oxide corresponds to the general formula R ₁ R ₂ R ₃ N → O, wherein R ₁ represents about 8 to about 18 carbon atoms, 0 to about 10 ethylene oxide moieties, and 0 to about 1 glyceryl moiety Containing an alkyl, alkenyl or monohydroxy alkyl radical, wherein R ₂ and R ₃ are from about 1 to about 3 carbon atoms, and from 0 to about 1 hydroxy group such as methyl, ethyl, propyl, hydroxyethyl, Or hydroxypropyl radicals. The arrow in the above formula is a conventional indication of a semipolar bond. Examples of amine oxides suitable for use in the present invention include dimethyl-dodecylamine oxide, oleyldi (2-hydroxyethyl) amine oxide, dimethyloctylamine oxide, dimethyl-decylamine oxide, dimethyl-tetra Decylamine oxide, 3,6,9-trioxaheptadecyldiethylamine oxide, di (2-hydroxyethyl) -tetradecylamine oxide, 2-dodecoxyethyldimethylamine oxide, 3-dode Cooxy-2-hydroxypropyldi (3-hydroxypropyl) amine oxide, dimethylhexadecylamine oxide.

Non-limiting examples of preferred nonionic surfactants for use herein include C8-C14 glucose amides, C8-C14 alkyl polyglucosides, sucrose cocoate, sucrose laurate, laumine oxide, cocoamine oxide, And mixtures thereof.

Amphoteric Foaming Surfactant

As used herein, the term "amphoteric foaming surfactant" is also intended to encompass zwitterionic surfactants, well known to those skilled in the art as a subset of amphoteric surfactants. will be.

A wide variety of amphoteric foaming surfactants can be used in the compositions of the present invention. Those widely described as derivatives of aliphatic secondary and tertiary amines, preferably wherein the nitrogen is in the cationic state, the aliphatic radicals are straight or branched chains, and one of the radicals is an ionizable water soluble group such as carboxy, Particularly useful are those containing sulfonates, sulfates, phosphates, or phosphonates.

Non-limiting examples of amphoteric surfactants useful in the compositions of the present invention include McCutcheon's, Detergents and Emulsifiers , North American edition (1986), published by Allured Publishing Corporation; And McCutcheon's, Functional Materials , North American Edition (1992), all of which are incorporated herein by reference in their entirety.

Non-limiting examples of amphoteric or zwitterionic surfactants include those selected from the group consisting of betaine, sultaine, hydroxysultine, alkyliminoacetate, iminodialkanoate, aminoalkanoate, and mixtures thereof. have.

Examples of betaines include coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl alphacarboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, cetyl dimethyl betaine (available from Lonza Corp. as Lonzaine 16SP), Lauryl bis- (2-hydroxyethyl) carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, lauryl bis- (2-hydroxypropyl) alpha-carboxyethyl betaine, coco dimethyl sulfopropyl betaine , Lauryl dimethyl sulfoethyl betaine, lauryl bis- (2-hydroxyethyl) sulfopropyl betaine, amidobetaine and amidosulfobetaine (herein RCONH (CH ₂ ) ₃ radicals on the nitrogen atom of betaine Attached), oleyl betaine (available as amphoteric Velvetex OLB-50 from Henkel), and cocamidopropyl betaine (available as Velvetex BK-35 and BA-35 from Henkel) .

Examples of sulfines and hydroxysultaines include materials such as cocamidopropyl hydroxysultine (available as Mirataine CBS from Rhone-Poulenc).

Amphoteric surfactants having the following structure are preferred for use herein:

Wherein R ¹ is unsubstituted, saturated or unsaturated, straight or branched alkyl having from about 9 to about 22 carbon atoms. Preferred R ¹ has about 11 to about 18 carbon atoms, more preferably about 12 to about 18 carbon atoms; Even more preferably about 14 to about 18 carbon atoms; m is an integer from 1 to about 3, more preferably from about 2 to about 3, even more preferably from about 3; n is 0 or 1, preferably 1; R ² and R ³ are those selected from the group consisting of alkyl having 1 to about 3 carbon atoms and unsubstituted or monosubstituted with a hydroxy group, preferred R ² and R ³ are CH ₃ ; X is selected from the group consisting of CO ₂ , SO ₃ and SO ₄ ; R ⁴ has 1 to about 5 carbon atoms and is selected from the group consisting of saturated or unsaturated, straight or branched, unsubstituted or monosubstituted hydroxy groups. When X is CO ₂ , R ⁴ preferably has 1 or 3, more preferably 1. When X is SO ₃ or SO ₄ , R ⁴ preferably has about 2 to about 4 carbon atoms, more preferably 3.

Examples of amphoteric surfactants of the invention include the following compounds:

Cetyl dimethyl betaine (also known as cetyl betaine, CTFA designation)

Cocamidopropyl Betaine

(Wherein the carbon number of R is about 9 to about 13),

Cocamidopropyl Hydroxy Sultine

Wherein R has from about 9 to about 13 carbon atoms.

Examples of other useful amphoteric surfactants are alkyliminoacetates, and iminodialkanoates and aminoalkanoates of the general formulas RN [(CH ₂ ) _m CO ₂ M] ₂ and RNH (CH ₂ ) _m CO ₂ M Wherein m is 1 to 4, R is C ₈ to C ₂₂ alkyl or alkenyl, and M is H, alkali metal, alkaline earth metal ammonium, or alkanol ammonium. Also included are imidazolinium and ammonium derivatives. Specific examples of suitable amphoteric surfactants include N-higher alkyl aspartic acids, sodium 3-dodecyl-aminopropionate, sodium, such as those prepared according to the teachings of US Pat. No. 2,438,091, which is incorporated herein by reference in its entirety. 3-dodecylaminopropane sulfonate; And products described in US Pat. No. 2,528,378, marketed under the trade name “Miranol,” and incorporated herein by reference in its entirety. Other examples of useful amphoteric materials include amphoteric phosphates such as coamidopropyl PG-dimonium chloride phosphate (available as Monaquat PTC from Mona Corp.). Also useful are ampoacetates, such as disodium lauroampodiacetate, sodium lauroampoacetate, and mixtures thereof.

Preferred foaming surfactants are ammonium lauroyl sarcosinate, sodium tridecetate sulfate, sodium lauroyl sarcosinate, ammonium laureth sulfate, sodium laureth sulfate, ammonium lauryl sulfate, sodium lauryl Sulfate, ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, sodium cetyl sulfate, sodium monolauryl phosphate, sodium cocoglyceryl ether sulfonate, sodium C ₉ -C ₂₂ Anionic foaming surfactants selected from the group consisting of soap, and combinations thereof; Nonionic foaming surfactants selected from the group consisting of laumine oxide, cocoamine oxide, decyl polyglucose, lauryl polyglucose, sucrose cocoate, C12-14 glucosamide, sucrose laurate, and combinations thereof field; Cationic foaming surfactants selected from the group consisting of fatty amines, di-fatty quaternary amines, tri-fatty quaternary amines, imidazolinium quaternary amines, and combinations thereof; Consisting of an amphoteric foaming surfactant selected from the group consisting of disodium lauroampodiacetate, sodium lauroampoacetate, cetyl dimethyl betaine, cocoamidopropyl betaine, cocoamidopropyl hydroxy sultaine, and combinations thereof Selected from the group.

Chelator

Articles of the invention may also include a safe effective amount of a chelator or chelating agent. As used herein, "chelator" or "chelating agent" means an active agent capable of removing metal ions from the system by forming a complex such that the metal ions cannot readily participate or catalyze chemical reactions. The introduction of chelating agents is particularly useful to provide protection against UV radiation, which can contribute to excessive scaling or skin texture changes, and other environmental factors that can cause skin damage.

A safe effective amount of chelating agent can be added to the compositions of the present invention, preferably from about 0.1% to about 10%, more preferably from about 1% to about 5% of the composition. Examples of chelators useful herein include US Pat. No. 5,487,884 (Bissett et al., Issued January 30, 1996); International Publication No. 91/16035 (Bush et al., Published October 31, 1995); And International Publication No. 91/16034 (Bush et al., Published October 31, 1995). Preferred chelators useful in the compositions of the present invention are furyldioxime and derivatives thereof.

Flavonoids

Articles of the invention may optionally include a flavonoid compound. Flavonoids are described extensively in US Pat. Nos. 5,686,082 and 5,686,367, both of which are incorporated herein by reference in their entirety. Flavonoids suitable for use in the present invention include flavanones selected from the group consisting of unsubstituted flavanones, monosubstituted flavanones, and mixtures thereof; A chalcone selected from the group consisting of unsubstituted chalcones, monosubstituted chalcones, disubstituted chalcones, trisubstituted chalcones, and mixtures thereof; flavones selected from the group consisting of unsubstituted flavones, monosubstituted flavones, disubstituted flavones, and mixtures thereof; One or more isoflavones; Coumarins selected from the group consisting of unsubstituted coumarins, monosubstituted coumarins, disubstituted coumarins, and mixtures thereof; Chromones selected from the group consisting of unsubstituted chromones, monosubstituted chromons, disubstituted chromons, and mixtures thereof; One or more dicoumarol; One or more chromanones; One or more chromanols; Their isomers (eg cis / trans isomers); And mixtures thereof. As used herein, the term "substituted" means a flavonoid in which one or more hydrogen atoms of the flavonoids are independently replaced by hydroxyl, C1-C8 alkyl, C1-C4 alkoxyl, O-glycoside, or the like, or a mixture of such substituents. .

Examples of suitable flavonoids include unsubstituted flavanones, monohydroxy flavanones (eg, 2′-hydroxy flavanones, 6-hydroxy flavanones, 7-hydroxy flavanones, and the like), monoalkoxy flavanones (eg 5-methoxy flavanone, 6-methoxy flavanone, 7-methoxy flavanone, 4'-methoxy flavanone, etc.), unsubstituted chalcones (especially unsubstituted trans-chalcones), monohydroxy chalcones (eg, 2'-hydroxy chalcone, 4'-hydroxy chalcone, etc.), dihydroxy chalcone (eg 2 ', 4-dihydroxy chalcone, 2', 4'-dihydroxy chalcone, 2,2'-di Hydroxy chalcone, 2 ', 3-dihydroxy chalcone, 2', 5'-dihydroxy chalcone, and the like, and trihydroxy chalcone (eg, 2 ', 3', 4'-trihydroxy chalcone, 4) , 2 ', 4'-trihydroxy chalcone, 2,2', 4'-trihydroxy chalcone, etc.), unsubstituted flavone, 7,2'-dihydroxy flavone, 3 ', 4'-dihydroxy Naphthoflavones, 4'-hydroxy flavones, 5,6-benzoflavones, and 7,8-benzople Labon, unsubstituted isoflavones, dydzein (7,4'-dihydroxy isoflavones), 5,7-dihydroxy-4'-methoxy isoflavones, soybean isoflavones (mixture extracted from soybeans), Unsubstituted coumarin, 4-hydroxy coumarin, 7-hydroxy coumarin, 6-hydroxy-4-methyl coumarin, unsubstituted chromone, 3-formyl chromone, 3-formyl-6-isopropyl chromone, Unsubstituted dicoumarol, unsubstituted chromanone, unsubstituted chromanol and mixtures thereof, but are not limited thereto.

Unsubstituted flavanones, methoxy flavanones, unsubstituted chalcones, 2 ', 4-dihydroxy chalcones and mixtures thereof are preferred for use herein. Most preferred are unsubstituted flavanones, unsubstituted chalcones (especially trans isomers), and mixtures thereof.

These may be synthetic or obtained as extracts from natural sources (eg plants). The natural source material may further be derivatized (eg, glycoside, ester or ether derivatives prepared after extraction from the natural source). Flavonoid compounds useful herein include a number of sources, such as Indofine Chemical Company, Inc. (Somerville, New Jersey), Steraloids, Inc. (Wilton, New Hampshire), and Aldrich Chemical Company, Inc. (Milwaukee, Wisconsin).

Mixtures of the above flavonoid compounds may also be used.

The flavonoid compounds described herein are preferably present at a concentration of about 0.01% to about 20%, more preferably about 0.1% to about 10%, most preferably about 0.5% to about 5% in the present invention.

Sterol

Articles of the invention may include a safe effective amount of one or more sterol compounds. Examples of useful sterol compounds include cytosterol, stigmasterol, campestrol, brassicasterol, lanosterol, 7-dehydrocholesterol, and mixtures thereof. They may be of synthetic origin (eg phytosterols) or extracted from natural sources such as botanical sources.

Anticellulite

Articles of the invention may also include a safe effective amount of an anticellulite agent. Suitable formulations may include, but are not limited to, xanthine compounds (eg, caffeine, theophylline, theobromine, and aminophylline).

Skin lightening

The article of the present invention may comprise a skin lightening agent. When used, the composition preferably comprises a skin lightening agent from about 0.1% to about 10% by weight, more preferably from about 0.2% to about 5% by weight, more preferably from about 0.5% by weight to the composition. About 2% by weight. Suitable skin lightening agents include those known in the art, including kojic acid, arbutin, ascorbic acid and derivatives thereof such as magnesium ascorbyl phosphate or sodium ascorbyl phosphate or other salts of ascorbyl phosphate. Skin lightening agents suitable for use herein are also co-pending patent application serial no. 08 / 479,935, filed June 7, 1995 in the name of Hillebrand, and corresponding PCT application US 95/07432, June 1995 12 day application); And co-pending patent application Ser. No. 08 / 390,152, filed Feb. 24, 1995 in the name of Kalla L. Kvalnes, Mitchell A. DeLong, Barton J. Bradbury, Curtis B. Motley, and John D. Carter. And those described in the corresponding PCT application US 95/02809 (filed March 1, 1995, published September 8, 1995).

Binder

The article of the present invention may optionally comprise a binder. A binder or binding material is useful for sealing several layers of the article to one another to maintain the integrity of the article. The binder may be in various forms including, but not limited to, spraying, webs, individual layers, bonding fibers, and the like. Suitable binders may include latex, polyamides, polyesters, polyolefins and combinations thereof.

Additional layers

In other embodiments, the articles of the present invention are recognized by those skilled in the art as distinct and distinct from the nonwoven layer, but in some respects may include one or more additional layers attached to the nonwoven layer. The additional layer is suitable for enhancing the overall grippability of the side of the article closest to the hand or other means, in order to exert a mechanical action on the surface to be cleansed. The additional layer is also suitable for enhancing the soft feel of the side of the article in contact with the site to be cleansed. In all cases, these additional layers may be referred to as layers of consecutive numbers, eg third layer, fourth layer, etc., in addition to the two layers essential for the article of the present invention.

Suitable additional layers can be expanded macroscopically. As used herein, “macroexpanded” refers to a web, ribbon, adapted to the surface of a three-dimensional molded structure such that both surfaces exhibit a three-dimensional molded pattern of surface deformations corresponding to the macroscopic cross section of the molded structure, and As a film, when the vertical distance between the observer's eye and the web plane is about 12 inches, the web, ribbon, and film are individually distinguishable from normal naked eyes (ie normal naked eyes with 20/20 vision), including the pattern. Means.

As used herein, "embossed" means that the molding structure of the material exhibits a pattern consisting primarily of protruding protrusions. On the other hand, "debossed" refers to the case where the shaped structure of the material exhibits a pattern consisting mainly of recessed capillary networks.

Preferred macroscopically expanded films include molded films that are structurally elastic films. Such films are described in US Pat. No. 5,554,145 to Roe et al., Sep. 10, 1996, which is incorporated herein by reference in its entirety.

Suitable materials for use in additional layers having a thickness of at least 1 millimeter include, but are not limited to, the web materials disclosed in US Pat. No. 5,518,801 to Chappell et al., Issued May 21, 1996, which is incorporated herein by reference in its entirety. It doesn't work.

Manufacturing method

Personal care articles of the present invention may include, but are not limited to, sprinkling, dip coating, spraying, slot coating, and roll delivery (eg, pressure rolls or kiss rolls). By adding a therapeutically potent member to a suitable sheet of nonwoven layer. Thereafter, the sheet of residual layer is placed on the first layer sheet, but not always, but preferably through the absence of therapeutic efficacy. The sheets are closed together by conventional sealing methods, including but not limited to heat, pressure, glue, ultrasound, and the like. Heat sealers can vary in design and, if sealing is not possible, low melt heat sealable fibrous webs, such as the polyamide fibrous web known as Wonder Under (Pellon, H.Levinson & Co., Chicago, IL). An intercalation layer of can be used between the layers for the above and other examples without changing the effectiveness or utility of the article. Thereafter, the sealed sheets are divided into units suitable for consumer use. Optional manufacturing steps may include calendaring, drying, creping, shrinking, stretching, or other mechanical deformation to flatten the article.

Methods of Delivery and Cleansing of Therapeutic or Aesthetic Agonists for Skin or Hair

The invention also relates to a method of cleansing the skin and / or hair with the personal care article of the invention. These methods include the following steps: a) a water insoluble substrate comprising a nonwoven layer; And a therapeutically effective member disposed adjacent to the water-insoluble substrate, wherein the member comprises a therapeutically effective composition containing a safe effective amount of an anionic polymer and a safe effective amount of cationic surfactant relative to the water insoluble substrate. 10 wt% to about 1000 wt%, wherein the composition wets a substantially dry disposable personal care article containing the article) and forms coacervate when the article is exposed to water; And b) contacting the wet article with skin or hair.

The article of the invention is water activated and therefore must be wetted with water before use. As used herein, "water activated" means that the present invention is provided to the consumer in a dry form used after wetting with water. If the articles of the present invention comprise foaming surfactants, they have been found to "activate" or foam upon contact with water and further stirring. Thus, the article is wetted by immersing it in water or placing it under a stream of water. If the article of the present invention contains a foaming surfactant, foam may be produced from the article by mechanically stirring and / or deforming the article before or during the contact with the skin or hair. The resulting foam is useful for cleansing the skin or hair. During the cleansing process and subsequent rinsing with water, any therapeutic or aesthetic agonist is deposited on the skin or hair. Deposition of therapeutic or aesthetic agonists is enhanced by incorporation of one or more deposition aids as well as physical contact of skin or hair with the substrate.

The following examples further illustrate and demonstrate embodiments within the scope of the invention. In the examples below, all components are listed by activity level. The examples are given for illustrative purposes only and are not to be construed as limiting the invention, as various changes are possible without departing from the spirit and scope of the invention.

Ingredients are identified by chemical name or CTFA name.

I. Cleansing parts

Example 1

Representative powdery cleansing members for articles of the invention are prepared in the following manner.

Cut 40.0 gms of bar soap containing the following ingredients:

ingredient weight% Soap (Magnesium and Sodium) 80.16 water 11.50 Stearic acid 5.70 NaCl 1.10 EDTA 0.25 Spices 1.15 Others (including pigments) 0.14 total 100

The bar soap pieces are combined with sodium bicarbonate in a ratio of 90:10 by weight. The mixture is ground in a standard three roll mill. The flakes are collected and stored in a suitable sealed container.

Example 2

Representative cleansing members comprising the following components are prepared.

ingredient weight% Decylpolyglucose 12.0 Cocamidopropyl Betaine 12.0 Sodium Lauroyl Sarcosinate 12.0 Butylene Glycol 3.6 PEG 14M 1.8 Polyquaternium-10 0.9 Dex panthenol 0.7 Phenoxyethanol 0.5 Benzyl alcohol 0.5 Methylparaben 0.45 Propylparaben 0.25 Disodium EDTA 0.2 water 55.1

Example 3

Representative cleansing members comprising the following components are prepared.

ingredient weight% Monosodium lauroyl glutamate 22.0 Cocamidopropyl Betaine 2.0 Sodium chloride 1.0 glycerin 2.5 water 72.5

The components are heated with gentle stirring together until homogeneous.

II. Lack of therapeutic efficacy

Example 4

The following components are mixed to prepare a representative skin conditioning member.

ingredient Example 4 SEFA * Cotonate 48.0 SEFA * Behenate 12.0 Petroleum 10.0 Glyceryl Tribehenate 5.0 Cholesterol ester 25.0

* SEFA is an acronym for sucrose esters of fatty acids.

¹ Hamplex TNP, Hampshire Chemical Co.

Example 5

Representative conditioning members for articles of the invention are made in the following manner.

ingredient Example 5 Hydrophobic Phase: SEFA * Cotonate 15.5 SEFA * Behenate 8.0 Tribehenin 6.0 Petroleum 4.0 C10-C30 Cholesterol / Lanosterol Ester 13.0 PEG 30 dipolyhydroxystearate ³ 3.0 Hydrophilic phase: glycerin 42.30 PVM / MA Decadiene Crosspolymer ⁴ 0.25 Sodium hydroxide (10% solution) 0.25 Gelatin Active Skin Care Ingredients: Panthenol 2.50 Nicotinamide 2.50 Urea 2.50 Allantoin 0.20

* SEFA is an acronym for sucrose esters of fatty acids.

¹ Available as Dow Corning by AMS-C30

² Marketed as Abil WE-09 by Goldschmidt

³ Marketed as Arlacel P135 by ICI

⁴ Stabileze 06 available from ISP

Process for all emulsions:

The hydrophobic phase is heated to 70 ° C., the hydrophobic active skin care component is added and stirred until homogeneous. The hydrophilic active skin care component and the hydrophilic phase component are premixed and, if necessary, gently heated to dissolve or disperse them. They are added slowly to the hydrophobic phase and stirring continues. Homogenize (high shear mixer; ultrasonic homogenizer; or high pressure homogenizer such as Microfluidizer from Microfluidics Corp.). It is applied immediately to the substrate surface or rapidly cooled to below room temperature in ice or ice water. If necessary, store in a controlled environment under nitrogen for chemical stability.

Examples 6-11

Representative conditioning members for articles of the invention are made in the following manner.

Part A Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 Sodium lauroyl ether sulfate (SLES, added as 27% active) 15.0 6.51 6.20 5.9 Cocamidopropyl Betaine ¹ 13.5 5.85 5.57 5.82 5.19 5.3 Sodium Lauroyl Sarcosinate ² 1.35 0.60 0.57 6.01 5.36 0.54 Decylpolyglucose ³ 5.80 5.18 Lauryl alcohol 1.31 0.56 0.54 0.54 Polyethylene imine ⁴ 7.87 3.38 3.22 2.64 2.36 3.2 Citric acid (added as 50% aqueous solution) 0.32 0.11 0.11 0.09 Tetrasodium EDTA 0.28 Sulfuric acid 5.4 2.37 2.25 2.2 Preservative 0.62 0.45 0.43 2.86 2.55 0.3 Sodium sulfate 7.9 3.47 3.21 3.0 glycerin 26.45 56.7 46.4 44.1 39.36 44.8 Sorbitol 5.0 SEFA * Cotonate 12.8 SEFA * Behenate 8.0

Part B-Polymer Gelling Agent

Gelatin 4.2 Polyacrylamide and Isoparaffin ⁵ 7.5 Polyurethane latex in 50% isopropanol ⁶ 34.1 Polyacrylate Copolymer ⁷ 7.5 Polystyrene Sulfonate Copolymer ⁸ 1.1 Chitosan lactate 5.4

Part C-Physical Gelling Agents

12-hydroxystearic acid 10.0 10.66 Stearyl alcohol 10.0 20.0 20.0 7.11 15.0

* SEFA is an acronym for sucrose esters of fatty acids.

¹ Marketed as Tegobetaine F by Goldschmidt

² available as Hamposyl L-30 (type 721) which is 31% active by Hampshire Chemical

³ Henkel sold as Plantaren 2000NP

⁴ Nippon Shokubai Co. Commercially available as Epomin SP-018 (molecular weight approx. 1800)

⁵ BF Goodrich available as Carbopol Ultrez

⁶ marketed by BF Goodrich as Sancure 2710 (prepared as a premix containing about 20% polymer, 30% water, 50% IPA)

⁶ Seppic Corp. Available on Sepigel 305

⁷ marketed as AQ38S by Eastman Chemical

The surfactant and fatty alcohol are blended with a slow impeller mixer while heating to 65 ° C. The heat is removed and allowed to cool to 65 ° C. with continued mixing. Add cationic polymer and stir until homogeneous. The remaining Part A component is added slowly with stirring. Homogenize to disperse SEFA as an emulsion. Titrate with concentrated sulfuric acid until the pH reaches about 6.5. The Part A composition is spread on a tray and dried in a suitable (vacuum or convection) oven at a temperature below 65 ° C. until essentially no water remains, to prepare a dry mixture. The dried Part A component is combined with the polymeric gelling agent from Part B and heated to dissolve or disperse. The resulting composition is combined with a physical gelling agent. Heat to melt and dissolve the gelling agent in the composition. Apply to substrate surface (s) or cool to room temperature.

Examples 12-17

Representative conditioning members for articles of the invention are prepared as described in Examples 6-11 using the following components.

Part A Example 12 Example 13 Example 14 Example 15 Example 16 Example 17 Sodium Lauroyl Sarcosinate ¹ 8.87 11.4 10.8 10.8 Polyethylene imine ² 7.39 7.50 7.50 9.5 9.0 9.0 water 4.43 3.00 3.00 5.7 5.4 5.4 Sulfuric acid 6.36 Quantity Quantity 8.1 7.7 7.7 Air freshener, other glycerin 34.45 52.5 45.0 41.3 39.25 34.25 Propylene glycol 2.50 Urea 2.50 2.50 2.0 1.9 1.9 Panthenol 2.0 1.9 1.9 Nicotinamide 2.50 2.50 2.0 1.9 1.9 Salicylic acid Polymethylsilsesquioxane ³ 4.20 4.20 Mica, Pearlescent 3.85 3.85 Stearylmethicone wax 5.0 SEFA Cotonate 5.0 Petroleum 5.0

Part B-Polymer Gelling Agent

Gelatin 0.1 Polyacrylamide and Isoparaffin ⁴ 16.0 12.0 12.0

Part C-Physical Gelling Agents

12-hydroxystearic acid 12.0 12.0 10.5 Carnauba Wax 18.0 14.1 14.1 Stearyl alcohol 8.0 8.0 7.0

¹ Marketed as Hamposyl L-95 (dry) by Hampshire Chemical

² Nippon Shokubai Co. Epomin SP-018 (molecular weight: about 1800) available from

³ Kobo, Inc. Available from Tospearl 145A

⁴ Seppic Corp. Available on Sepigel 305

III. Intermediate personal care supplies

Example 18

Representative skin cleansing articles are made in the following manner.

4 g of the cleansing member of Example 2 is applied to one side of a permeable fusible web comprising low melt heat sealable polyamide fibers. The permeable web is Wonder Under (manufactured by Pelon, H. Levinson & Co. (Chicago, Ill.)). The cleansing member is applied to an oval area of approximately 13 cm x 18 cm. The cleansing member is air dried. A layer of 2 oz / yd ² polyester batter cut to the same size as the web is laid over the fusible web. The polyester batting has a basis weight of 2 oz / yd ² and comprises fiber blends of average diameters of about 23 microns and 40 microns, with at least a portion of them being corrugated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. Betting is considered to be thermally bonded without the use of adhesives. The nonwoven layer is placed under the fusible web to form the second side of the article. Nonwovens are spunlace blends of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, which are hydroapertured to form holes of about 2 mm diameter and have a basis weight of about 70 gsm. The shape of the article is an ellipse of about 122 mm x 160 mm. Heat-sealing molds using pressure-platen heat seals such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA), which seal the layers together in a lattice pattern using point bonds. Each about 4 mm in diameter, about 51 individual suture points are uniformly distributed. Trim the items and prepare them for use.

Example 19

Representative skin cleansing articles are made in the following manner.

The cleansing member of Example 2 was continuously extruded through the coating head into four lines, each separated by a distance of 20 mm, 40 mm and 20 mm, measuring the width across the web to be a pair of parallel lines on each side of the web. To one side of the first base material. The cleansing member is extruded at a rate such that 4.4 g of cleansing member per output article is produced. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, hydrated to form holes of about 2 mm diameter, with a basis weight of about 70 gsm. A second web, an airlaid Lofty low density bet, is continuously injected over the first substrate and placed in contact with the surfactant containing layer. The bet comprises a blend of 30% 15 denier PET fibers, 35% 3 denier bicomponent fibers with PET core and PE sheath and 10% denier bicomponent fibers 35% of the same core-sheath composition, with a basis weight per square meter About 100 grams (gsm). The web is continuously injected into an ultrasonic suture that sutures in a dot pattern that includes a grid of 4 mm diameter suture points evenly distributed throughout the web. The web is cut into individual articles of about 120 mm × 160 mm rectangular size with rounded corners, with a total of about 51 seams per article.

IV. Personal Care Articles of the Invention

Example 20

Representative skin cleansing and conditioning articles are made in the following manner.

3 g of the skin conditioning composition of Example 12 is applied to each side of the finished article of Example 18 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Example 21

Representative skin cleansing and conditioning articles are made in the following manner.

3 g of the skin conditioning composition of Example 5 is applied to each side of the finished article of Example 19 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Example 22

Representative skin cleansing and conditioning articles are made in the following manner.

3 g of the skin conditioning composition of Example 4 is applied to each side of the finished article of Example 19 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Example 23

Representative skin cleansing and conditioning articles are made in the following manner.

3 g of the skin conditioning composition of Example 12 is applied to each side of the finished article of Example 19 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Examples 24-31

Using the skin conditioning compositions of Examples 6-10, and 15-17, representative skin cleansing and conditioning articles are prepared in the following manner.

4 g of cleansing member of Example 2 are evenly spread by hand over the loft bet. The bet comprises a blend of 30% 15 denier PET fibers, 35% 3 denier bicomponent fibers with PET core and PE sheath and 10% denier bicomponent fibers 35% of the same core-sheath composition, about 100 grams per square meter Air laid Lofty low density bets with a basis weight of (gsm). A cleansing member-coated side of the batting with a fibrous nonwoven layer of approximately 65 gsm in base weight and a wet entangled blend of 55% cellulose and 45% polyester (commercially available as Technicloth II from Texwipe Company (Saddle River, NJ)) Lay on. The layers are sutured together using a peristaltic suture plate using an unheated plate with inverted thimble reservoirs evenly distributed in a hexagonal grid pattern. The thimble reservoir is about 1.2 cm in diameter at the base and about 2 cm apart from the center-center. Land portions between the dimples on the non-heated plate are concave several mm inwards to form interconnected furrows. The heating plate has an outer ridge that exactly fits into the furrow on the land portion of the unheated plate. The heating plate is in contact with the cellulose / polyester substrate and heat sealed using a pressure plate heat seal device such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). The resulting unfinished article has a significant thimble with raised batting face and shorter dimples or “buttons” with raised cellulose / polyester base face of the article, both sides being easy to grip. The article is cut into about 120 mm x 160 mm rectangles. 3 g of skin conditioning composition per article is pipetted into the furrow while the composition is hot to cool and solidify. Pack the goods until use.

Examples 32-33

Representative skin cleansing and conditioning articles are prepared using the skin conditioning compositions of Examples 13 and 14 in the following manner.

The 120 mm x 160 mm cut surface of the substrate is immersed in the composition bath until its weight increases to about 8 g to apply the liquid cleansing member of Example 3 to the first substrate. The substrate comprises a blend of 30% 15 denier PET fibers, 35% 3 denier bicomponent fibers with PET core and PE sheath and 10% denier bicomponent fibers 35% of the same core-sheath composition, and about 100 grams per square meter ( bet with a basis weight of gsm). Dry the substrate. A spunlace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, which is hydrated to form pieces of a second substrate having a pore diameter of about 2 mm and a basis weight of about 70 gsm. Place over the substrate. The substrates are stitched together using an ultrasonic suture that sutures in a dot pattern that includes a lattice of 4 mm diameter suture points distributed evenly over the article. The composition is injected through an injection reservoir maintained at about 60 ° C. and a slotted rolling device having a machined 1.5 mm gap to apply 4 g of skin conditioning composition evenly over both sides of the article. The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Example 34

Representative skin cleansing and conditioning articles are made in the following manner.

4 g of cleansing member of Example 2 are evenly spread by hand over the loft bet. The batting comprises a polyester fiber of about 30 micron average diameter and is a 4 oz / sq yd polyester batting, cut to 130 mm x 175 mm and bonded with an adhesive, for example Stearns Textiles (Cincinnati, OH Is sold as Mountain Mist Extra Heavy Batting # 205. A fibrous nonwoven layer having a basis weight of about 65 gsm and a wet entangled blend of 55% cellulose and 45% polyester (commercially available as Technicloth II from Texwipe Company (Saddle River, NJ)) was applied to the surfactant coating side of the batting. Lay on. The layers are stitched together using a peristaltic suture plate using an unheated plate having an inverted thimble reservoir evenly distributed in a hexagonal grid pattern. The thimble reservoir is about 1.2 cm in diameter at the base and about 1.5 cm apart from the center-center. Land portions between the dimples on the unheated plate look upwards a few mm to form ridges that are connected to each other. The heating plate has an outer furrow that exactly fits into the elevation of the unheated plate. The heating plate is in contact with the cellulose / polyester substrate and heat sealed using a pressure plate heat seal device such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). The resulting unfinished article has a three-dimensional feature on both sides that facilitates foaming and is easy to grab during use and slip along the skin surface. The article is cut into about 120 mm x 160 mm rectangles.

Skin Conditioning Reversal Emulsion Paste is prepared for use with this article as follows:

ingredient % PEG 30-dipolyhydroxystearate 3.0 SEFA Cotonate 20.0 Petroleum 4.0 Tribehenin 5.0 C10-C30 Cholesterol / Lanosterol Ester 13.0 SEFA Behenate 5.0 glycerin 50.0

The fat-soluble component is heated to 70 ° C. while stirring. Glycerin is added slowly with vigorous stirring. Homogenize the composition. Skin conditioning reversal emulsion paste is pipetted hot into the pressed area on the cellulose / polyester side of the article. The composition is quickly cooled to a semisolid paste. Pack the goods until use.

Example 35

Representative skin conditioning articles are prepared in the following manner using the skin conditioning composition of Example 7.

The coating composition is divided into four strips, each 5 mm wide, separated by a distance of 20 mm, 40 mm and 20 mm so that the width across the web is measured and a pair of parallel lines on each side of the web. It is continuously extruded through and applied to one side of the first substrate. The composition is extruded at a rate that yields 3 g of composition per finished article. The substrate is a spunlace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, hydrated to form pores of about 2 mm diameter with a basis weight of about 70 gsm. A second web, an airlaid lofty low density bet, is continuously infused over the first substrate and placed in contact with the first substrate on a side that does not contain the skin conditioning composition. The bet comprises a blend of 30% 15 denier PET fibers, 35% 3 denier bicomponent fibers with PET core and PE sheath and 10% denier bicomponent fibers 35% of the same core-sheath composition, with a basis weight per square meter It is about 100 grams (gsm). The web is continuously injected into an ultrasonic suture that sutures in a dot pattern that includes a grid of 4 mm diameter suture points evenly distributed throughout the web. The web is cut into individual articles of about 120 mm × 160 mm rectangular size with rounded corners having a total of about 51 suture points per article.

Example 36

An exemplary skin conditioning article is prepared using the skin conditioning composition of Example 16 in the following manner.

The conditioning composition is continuously run through the coating head in four strips, each 5 mm wide, separated at a distance of 20 mm, 40 mm and 20 mm so that the width across the web is measured and a pair of parallel lines on each side of the web. It extrudes and apply | coats to one side of a 1st base material. The composition is extruded at a rate such that 1.1 g of the composition is produced per finished article. The substrate is a spunlace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, hydrated to form pores of about 2 mm diameter and having a basis weight of about 70 gsm. A second web, an airlaid lofty low density bet, is continuously infused over the first substrate and placed in contact with the first substrate on a side that does not contain the skin conditioning composition. The bet comprises a blend of 10% 15 denier PET fibers, 50% 3 denier bicomponent fibers with a PET core and PE sheath and 10% denier bicomponent fibers of 40% of the same core-sheath composition, with a basis weight per square meter. About 80 grams (gsm). The web is continuously injected into an ultrasonic suture that sutures in a dot pattern that includes a grid of 4 mm diameter suture points distributed evenly over the web. The web is cut into individual articles of about 120 mm x 90 mm rectangular size with rounded corners, with a total of about 51 seams per article. The article is convenient for application to narrower areas of the skin, such as the face, elbows, necks and / or feet.

Example 37

A representative skin cleansing and conditioning article is prepared using the skin conditioning composition of Example 16.

The cleansing member of Example 2 was continuously extruded through the coating head into four lines, each separated by a distance of 20 mm, 40 mm and 20 mm, measuring the width across the web to be a pair of parallel lines on each side of the web. To one side of the first base material. The cleansing member is extruded at a rate such that 0.52 g of cleansing member per output article is produced. The substrate is a spunlace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, hydrated to form pores of about 2 mm diameter with a basis weight of about 70 gsm. A second substrate web, an airlaid lofty low density bet, is continuously injected over the first substrate and placed in contact with the surfactant layer. The bet comprises a blend of 10% 15 denier PET fibers, 50% 3 denier bicomponent fibers with a PET core and PE sheath and 10% denier bicomponent fibers of 40% of the same core-sheath composition, with a basis weight per square meter. It is about 100 grams (gsm). The same third substrate web as the second substrate web is continuously injected over the second substrate web and placed in contact with the second substrate. The web is continuously injected into an ultrasonic suture that sutures in a dot pattern that includes a grid of 4 mm diameter suture points distributed evenly over the web. From the hot reservoir pumped through the slot dye, slot coating the skin conditioning composition on both sides of the substrate web (added about 55 gsm per side) at a ratio equal to 1.25 g of the skin conditioning composition per final article, and the composition is external to the article. Pass the cooling fan to cool rapidly on the surface. The web is cut into individual articles of about 120 mm x 90 mm rectangular size with rounded corners.

Example 38

Representative skin cleansing and conditioning articles are made in the following manner.

The substrate is produced by an air laying process. A first thin web of 20 gsm continuous polypropylene filamentated fiber is injected into a continuous molding screen. Cellulose (Kraft fiber) comprising the second web is airlaid on the first web at a rate of 100 gsm. The surfactant composition of Example 1 is co-metered with cellulose fibers at a rate of about 80 gsm. The same third web as the first web is injected into the air- laid cellulose. The substrate is prepared by thermally bonding the edges and point-sealing approximately 51, 3 mm points of a 10 inch by 8.5 inch rectangular section of the composite web. The skin conditioning composition of Example 15 is melted and slot coated evenly on both sides of the article at a rate of 3 g of composition per article or 1.5 g per side and cooled rapidly. Keep the package until you use it.

Example 39

Representative skin cleansing and conditioning articles are made in the following manner.

The article of Example 38 is prepared except that a biodegradable polylactic acid polymer is used instead of polypropylene to prepare a biodegradable article.

Claims (10)

A substantially dry disposable personal care article, the article comprising: a) water insoluble substrate; And b) a therapeutically potent member disposed adjacent to the water-insoluble substrate, wherein the therapeutically potent member contains from 10% to 1000% by weight of a therapeutically potent composition containing, relative to the water-insoluble substrate: 1) a safe effective amount of anionic polymer; 2) a safe effective amount of cationic surfactant Wherein the composition forms coacervate when the article is exposed to water. The article of claim 1, wherein the nonwoven layer comprises fibers selected from the group consisting of natural fibers, synthetic fibers, and combinations thereof. 3. The method of claim 1 or 2, wherein the nonwoven layer comprises a material selected from the group consisting of cellulosic nonwovens, sponges (ie, both natural and synthetic), molded films, batting, and combinations thereof. Item characterized by. The method of claim 1, wherein the anionic polymer is a polyacrylic acid polymer, a polyacrylamide polymer, a copolymer of acrylic acid, acrylamide, and other natural or synthetic polymers, naturally derived rubbers, and combinations thereof. Article, characterized in that selected from the group consisting of. 5. The cationic surfactant according to claim 1, wherein the cationic surfactant consists of fatty amines, di-fatty quaternary amines, tri-fatty quaternary amines, imidazolinium quaternary amines, and combinations thereof. An article selected from the group. The method of claim 1, wherein the absence of therapeutic efficacy is a vitamin compound, a skin treatment agent, an anti-acne agent, an anti-wrinkle agent, an anti-skin atrophy agent, an anti-inflammatory agent, a local anesthetic agent, an artificial tanning agent and a tanning promoter, Further comprising a therapeutic agonist selected from the group consisting of antibacterial agents, antifungal agents, antiviral agents, enzymes, sunscreen agents, antioxidants, skin dermabrasion agents, hydrophobic conditioning agents, hydrophilic conditioning agents, and combinations thereof. article. The article according to any one of claims 1 to 6, which further contains a cationic polymer. A method of conditioning skin and / or hair, the method comprising the following steps: a) wetting the article according to claim 1; And b) contacting the skin and / or hair with a moistened article. 9. The article according to claim 1, wherein the article further contains a foaming surfactant. A method of cleansing skin and / or hair, the method comprising the following steps: a) wetting the article according to claim 1; And b) contacting the skin and / or hair with a moistened article.