KR20010043111A - Ｃ형 간염 바이러스성 감염과 관련된 질환의 효소적 핵산치료제 - Google Patents
Ｃ형 간염 바이러스성 감염과 관련된 질환의 효소적 핵산치료제 Download PDFInfo
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- KR20010043111A KR20010043111A KR1020007011999A KR20007011999A KR20010043111A KR 20010043111 A KR20010043111 A KR 20010043111A KR 1020007011999 A KR1020007011999 A KR 1020007011999A KR 20007011999 A KR20007011999 A KR 20007011999A KR 20010043111 A KR20010043111 A KR 20010043111A
- Authority
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- South Korea
- Prior art keywords
- ribozyme
- rna
- region
- artificial sequence
- stem
- Prior art date
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- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 73
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 72
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 72
- 230000002255 enzymatic effect Effects 0.000 title claims abstract description 45
- 201000010099 disease Diseases 0.000 title claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 4
- 238000010306 acid treatment Methods 0.000 title description 2
- 208000010710 hepatitis C virus infection Diseases 0.000 title 1
- 230000010076 replication Effects 0.000 claims abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 1550
- 102000053642 Catalytic RNA Human genes 0.000 claims description 1478
- 108090000994 Catalytic RNA Proteins 0.000 claims description 1476
- 108091092562 ribozyme Proteins 0.000 claims description 1476
- 241000711549 Hepacivirus C Species 0.000 claims description 1025
- 238000000034 method Methods 0.000 claims 27
- 102000002227 Interferon Type I Human genes 0.000 claims 14
- 108010014726 Interferon Type I Proteins 0.000 claims 14
- 238000012986 modification Methods 0.000 claims 9
- 230000004048 modification Effects 0.000 claims 9
- 210000004962 mammalian cell Anatomy 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 108700026244 Open Reading Frames Proteins 0.000 claims 6
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 4
- 238000002651 drug therapy Methods 0.000 claims 4
- 230000000977 initiatory effect Effects 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 4
- 238000011191 terminal modification Methods 0.000 claims 4
- 230000005026 transcription initiation Effects 0.000 claims 4
- 230000005030 transcription termination Effects 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 206010019663 Hepatic failure Diseases 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 102000003996 Interferon-beta Human genes 0.000 claims 2
- 108090000467 Interferon-beta Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000007882 cirrhosis Effects 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 229960001388 interferon-beta Drugs 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- ODDDVFDZBGTKDX-VPCXQMTMSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]pyrimidine-2,4-dione Chemical group C1=CC(=O)NC(=O)N1[C@]1(C)O[C@H](CO)[C@@H](O)[C@H]1O ODDDVFDZBGTKDX-VPCXQMTMSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 208000000857 Hepatic Insufficiency Diseases 0.000 claims 1
- 108091092195 Intron Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 241000251131 Sphyrna Species 0.000 description 1964
- 108090001102 Hammerhead ribozyme Proteins 0.000 description 527
- 101150058502 Acaca gene Proteins 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/122—Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
C형 간염의 발현 및/또는 복제를 조절하는 효소적 핵산 분자.
Description
SEQUENCE LISTING
＜110＞ RIBOZYME PHARMACEUTICALS, INC.
2950 Wilderness Place
Boulder, Colorado 80301
USA
＜120＞ ENZYMATIC NUCLEIC ACID TREATMENT OF
DISEASES OR CONDITIONS RELATED TO HEPATITIS C
VIRUS INFECTION
＜130＞ 241/078-PCT
＜140＞ PCT/US99/09027
＜141＞ 1999-04-26
＜150＞ 09/274,553
＜151＞ 1999-03-23
＜150＞ 09/257,608
＜151＞ 1999-02-25
＜150＞ 60/100,842
＜151＞ 1998-09-18
＜150＞ 60/083,217
＜151＞ 1998-04-27
＜160＞ 3118
＜170＞ FastSEQ for Windows Version 3.0
＜210＞ 1
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1
cuacugucuu cacgc 15
＜210＞ 2
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2
aaagcgucua gccau 15
＜210＞ 3
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3
agcgucuagc caugg 15
＜210＞ 4
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 4
ugagugucgu gcagc 15
＜210＞ 5
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 5
gagccauagu ggucu 15
＜210＞ 6
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 6
uaguggucug cggaa 15
＜210＞ 7
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 7
ggugaguaca ccgga 15
＜210＞ 8
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 8
accggguccu uucuu 15
＜210＞ 9
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 9
ggguccuuuc uugga 15
＜210＞ 10
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 10
gguccuuucu uggau 15
＜210＞ 11
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 11
guugggucgc gaaag 15
＜210＞ 12
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 12
aaggccuugu gguac 15
＜210＞ 13
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 13
gggugcuugc gagug 15
＜210＞ 14
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 14
gggaggucuc guaga 15
＜210＞ 15
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 15
gaggucucgu agacc 15
＜210＞ 16
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 16
gucucguaga ccgug 15
＜210＞ 17
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 17
uaaaccucaa agaaa 15
＜210＞ 18
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 18
caaacguaac accaa 15
＜210＞ 19
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 19
caaccgucgc ccaca 15
＜210＞ 20
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 20
gagcggucac aaccu 15
＜210＞ 21
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 21
guaaggucau cgaua 15
＜210＞ 22
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 22
uuuuuuuuuu uuuuu 15
＜210＞ 23
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 23
gguggcucca ucuua 15
＜210＞ 24
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 24
gcuccaucuu agccc 15
＜210＞ 25
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 25
uccaucuuag cccua 15
＜210＞ 26
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 26
ccaucuuagc ccuag 15
＜210＞ 27
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 27
uagcccuagu cacgg 15
＜210＞ 28
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 28
cccuagucac ggcua 15
＜210＞ 29
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 29
cacggcuagc uguga 15
＜210＞ 30
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 30
gaaagguccg ugagc 15
＜210＞ 31
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 31
gcgugaacug augaggccgu uaggccgaaa caguag 36
＜210＞ 32
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 32
auggcuacug augaggccgu uaggccgaaa cgcuuu 36
＜210＞ 33
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 33
ccauggccug augaggccgu uaggccgaaa gacgcu 36
＜210＞ 34
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 34
gcugcaccug augaggccgu uaggccgaaa cacuca 36
＜210＞ 35
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 35
agaccaccug augaggccgu uaggccgaaa uggcuc 36
＜210＞ 36
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 36
uuccgcacug augaggccgu uaggccgaaa ccacua 36
＜210＞ 37
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 37
uccggugcug augaggccgu uaggccgaaa cucacc 36
＜210＞ 38
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 38
aagaaagcug augaggccgu uaggccgaaa cccggu 36
＜210＞ 39
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 39
uccaagacug augaggccgu uaggccgaaa ggaccc 36
＜210＞ 40
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 40
auccaagcug augaggccgu uaggccgaaa aggacc 36
＜210＞ 41
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 41
cuuucgccug augaggccgu uaggccgaaa cccaac 36
＜210＞ 42
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 42
guaccaccug augaggccgu uaggccgaaa ggccuu 36
＜210＞ 43
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 43
cacucgccug augaggccgu uaggccgaaa gcaccc 36
＜210＞ 44
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 44
ucuacgacug augaggccgu uaggccgaaa ccuccc 36
＜210＞ 45
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 45
ggucuaccug augaggccgu uaggccgaaa gaccuc 36
＜210＞ 46
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 46
cacgguccug augaggccgu uaggccgaaa cgagac 36
＜210＞ 47
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 47
uuucuuucug augaggccgu uaggccgaaa gguuua 36
＜210＞ 48
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 48
uuggugucug augaggccgu uaggccgaaa cguuug 36
＜210＞ 49
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 49
ugugggccug augaggccgu uaggccgaaa cgguug 36
＜210＞ 50
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 50
agguugucug augaggccgu uaggccgaaa ccgcuc 36
＜210＞ 51
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 51
uaucgaucug augaggccgu uaggccgaaa ccuuac 36
＜210＞ 52
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 52
aaaaaaacug augaggccgu uaggccgaaa aaaaaa 36
＜210＞ 53
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 53
uaagaugcug augaggccgu uaggccgaaa gccacc 36
＜210＞ 54
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 54
gggcuaacug augaggccgu uaggccgaaa uggagc 36
＜210＞ 55
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 55
uagggcucug augaggccgu uaggccgaaa gaugga 36
＜210＞ 56
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 56
cuagggccug augaggccgu uaggccgaaa agaugg 36
＜210＞ 57
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 57
ccgugaccug augaggccgu uaggccgaaa gggcua 36
＜210＞ 58
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 58
uagccgucug augaggccgu uaggccgaaa cuaggg 36
＜210＞ 59
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 59
ucacagccug augaggccgu uaggccgaaa gccgug 36
＜210＞ 60
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 60
gcucacgcug augaggccgu uaggccgaaa ccuuuc 36
＜210＞ 61
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 61
uauggugcug augagncgaa agugucg 27
＜210＞ 62
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 62
gguccugcug augagncgaa aggcugc 27
＜210＞ 63
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 63
cucccggcug augagncgaa agggggg 27
＜210＞ 64
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 64
uuccgcacug augagncgaa accacua 27
＜210＞ 65
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 65
uccggugcug augagncgaa acucacc 27
＜210＞ 66
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 66
uccuggccug augagncgaa auuccgg 27
＜210＞ 67
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 67
uugaucccug augagncgaa agaaagg 27
＜210＞ 68
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 68
aggcauucug augagncgaa agcgggu 27
＜210＞ 69
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 69
acucggccug augagncgaa agcaguc 27
＜210＞ 70
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 70
ccaacaccug augagncgaa acucggc 27
＜210＞ 71
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 71
gcgaccccug augagncgaa acacuac 27
＜210＞ 72
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 72
cuuucgccug augagncgaa acccaac 27
＜210＞ 73
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 73
caggcagcug augagncgaa accacaa 27
＜210＞ 74
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 74
agcaccccug augagncgaa aucaggc 27
＜210＞ 75
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 75
cacucgccug augagncgaa agcaccc 27
＜210＞ 76
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 76
ucuacgacug augagncgaa accuccc 27
＜210＞ 77
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 77
ggucuaccug augagncgaa agaccuc 27
＜210＞ 78
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 78
cacgguccug augagncgaa acgagac 27
＜210＞ 79
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 79
ggaacuucug augagncgaa acguccu 27
＜210＞ 80
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 80
gcccgggcug augagncgaa acuugac 27
＜210＞ 81
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 81
cgcccggcug augagncgaa aacuuga 27
＜210＞ 82
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 82
acgaucucug augagncgaa accaccg 27
＜210＞ 83
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 83
cacaccccug augagncgaa acguggg 27
＜210＞ 84
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 84
gucuucccug augagncgaa agucgcg 27
＜210＞ 85
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 85
cguucggcug augagncgaa agucuuc 27
＜210＞ 86
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 86
ccguucgcug augagncgaa aagucuu 27
＜210＞ 87
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 87
agguugccug augagncgaa accguuc 27
＜210＞ 88
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 88
uuggggacug augagncgaa agguugu 27
＜210＞ 89
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 89
ccuugggcug augagncgaa auagguu 27
＜210＞ 90
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 90
ggucggccug augagncgaa agccuug 27
＜210＞ 91
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 91
caggccccug augagncgaa acccucg 27
＜210＞ 92
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 92
ccaggcucug augagncgaa agcccag 27
＜210＞ 93
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 93
ccaagggcug augagncgaa acccagg 27
＜210＞ 94
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 94
aggggcccug augagncgaa aggguac 27
＜210＞ 95
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 95
ugccauacug augagncgaa aggggcc 27
＜210＞ 96
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 96
auugccacug augagncgaa agagggg 27
＜210＞ 97
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 97
gugacagcug augagncgaa agccauc 27
＜210＞ 98
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 98
gcggggucug augagncgaa acaggag 27
＜210＞ 99
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 99
aggccggcug augagncgaa agccgcg 27
＜210＞ 100
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 100
ccccaaccug augagncgaa aggccgg 27
＜210＞ 101
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 101
gggcccccug augagncgaa acuaggc 27
＜210＞ 102
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 102
uuacccacug augagncgaa auugcgc 27
＜210＞ 103
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 103
uaucgaucug augagncgaa accuuac 27
＜210＞ 104
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 104
ggguauccug augagncgaa augaccu 27
＜210＞ 105
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 105
gugagggcug augagncgaa aucgaug 27
＜210＞ 106
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 106
gucggcgcug augagncgaa agccgca 27
＜210＞ 107
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 107
ggucggccug augagncgaa aagccgc 27
＜210＞ 108
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 108
cggaaugcug augagncgaa accccau 27
＜210＞ 109
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 109
cgagcggcug augagncgaa auguacc 27
＜210＞ 110
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 110
acgagcgcug augagncgaa aauguac 27
＜210＞ 111
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 111
cgccgaccug augagncgaa agcggaa 27
＜210＞ 112
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 112
gggcgcccug augagncgaa acgagcg 27
＜210＞ 113
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 113
cgccccccug augagncgaa agggggg 27
＜210＞ 114
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 114
gaacccgcug augagncgaa acaccau 27
＜210＞ 115
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 115
ccuccagcug augagncgaa acccgga 27
＜210＞ 116
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 116
uccuccacug augagncgaa aacccgg 27
＜210＞ 117
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 117
uguugcgcug augagncgaa aguucac 27
＜210＞ 118
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 118
accgggccug augagncgaa aguuccc 27
＜210＞ 119
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 119
aaagagccug augagncgaa accgggc 27
＜210＞ 120
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 120
agagaaacug augagncgaa agcaacc 27
＜210＞ 121
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 121
ugccucacug augagncgaa acacaau 27
＜210＞ 122
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 122
uaugcaucug augagncgaa aucaugc 27
＜210＞ 123
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 123
cgcagggcug augagncgaa acgcacc 27
＜210＞ 124
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 124
ucucccgcug augagncgaa acgcagg 27
＜210＞ 125
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 125
uucuccccug augagncgaa aacgcag 27
＜210＞ 126
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 126
acaacggcug augagncgaa aggcguu 27
＜210＞ 127
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 127
acccaaccug augagncgaa acgggag 27
＜210＞ 128
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 128
gcuaccccug augagncgaa acaacgg 27
＜210＞ 129
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 129
ugagcgccug augagncgaa acccaac 27
＜210＞ 130
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 130
gcaaguccug augagncgaa acguggc 27
＜210＞ 131
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 131
aacgagccug augagncgaa agucgac 27
＜210＞ 132
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 132
ccccaaccug augagncgaa agcaagu 27
＜210＞ 133
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 133
ccgcccccug augagncgaa acgagca 27
＜210＞ 134
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 134
ggaacagcug augagncgaa aagcggc 27
＜210＞ 135
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 135
cggaacacug augagncgaa aaagcgg 27
＜210＞ 136
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 136
auggcggcug augagncgaa acagaaa 27
＜210＞ 137
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 137
cauggcgcug augagncgaa aacagaa 27
＜210＞ 138
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 138 ccccacgcug augagncgaa acauggc 27
＜210＞ 139
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 139
gaaaacgcug augagncgaa auccgca 27
＜210＞ 140
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 140
cgaggaacug augagncgaa acggauc 27
＜210＞ 141
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 141
acgaggacug augagncgaa aacggau 27
＜210＞ 142
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 142
gacgaggcug augagncgaa aaacgga 27
＜210＞ 143
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 143
agacgagcug augagncgaa aaaacgg 27
＜210＞ 144
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 144
gaccugacug augagncgaa acauggc 27
＜210＞ 145
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 145
gugaccucug augagncgaa auacaug 27
＜210＞ 146
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 146
augcggucug augagncgaa accugau 27
＜210＞ 147
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 147
uauccaccug augagncgaa acagcuu 27
＜210＞ 148
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 148
gccaccacug augagncgaa auccacg 27
＜210＞ 149
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 149
ccgcuagcug augagncgaa acucccc 27
＜210＞ 150
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 150
ggcccgccug augagncgaa aggacuc 27
＜210＞ 151
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 151
aguaggccug augagncgaa aggcccg 27
＜210＞ 152
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 152
ggaauagcug augagncgaa aggcaag 27
＜210＞ 153
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 153
cauggaacug augagncgaa aguaggc 27
＜210＞ 154
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 154
accauggcug augagncgaa auaguag 27
＜210＞ 155
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 155
caccaugcug augagncgaa aauagua 27
＜210＞ 156
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 156
acuuguccug augagncgaa auggagc 27
＜210＞ 157
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 157
cugagcgcug augagncgaa acuuguc 27
＜210＞ 158
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 158
ccugagccug augagncgaa aacuugu 27
＜210＞ 159
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 159
caucccucug augagncgaa agcgaac 27
＜210＞ 160
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 160
uauaggucug augagncgaa auggggc 27
＜210＞ 161
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 161
cucgguacug augagncgaa aggugau 27
＜210＞ 162
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 162
ccagcagcug augagncgaa aaggccu 27
＜210＞ 163
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 163
ggugcgucug augagncgaa augccag 27
＜210＞ 164
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 164
aggugcgcug augagncgaa aaugcca 27
＜210＞ 165
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 165
cacugcccug augagncgaa aggugcg 27
＜210＞ 166
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 166
gguacgacug augagncgaa accacac 27
＜210＞ 167
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 167
cagguaccug augagncgaa auaccac 27
＜210＞ 168
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 168
acgcaggcug augagncgaa acgauac 27
＜210＞ 169
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 169
caccugccug augagncgaa acgcagg 27
＜210＞ 170
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 170
uacacugcug augagncgaa accacac 27
＜210＞ 171
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 171
ccacuaccug augagncgaa acagggc 27
＜210＞ 172
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 172
uccccaccug augagncgaa acaacag 27
＜210＞ 173
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 173
ccggacccug augagncgaa aucgguc 27
＜210＞ 174
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 174
ggcaccgcug augagncgaa accgauc 27
＜210＞ 175
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 175
uuauacgcug augagncgaa aggggca 27
＜210＞ 176
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 176
ccaguuacug augagncgaa acguagg 27
＜210＞ 177
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 177
ccccagucug augagncgaa auacgua 27
＜210＞ 178
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 178
acagccacug augagncgaa accaguu 27
＜210＞ 179
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 179
uacagcccug augagncgaa aaccagu 27
＜210＞ 180
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 180
auccaugcug augagncgaa acagcca 27
＜210＞ 181
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 181
uugcacgcug augagncgaa agggccc 27
＜210＞ 182
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 182
ccccccccug augagncgaa auguugc 27
＜210＞ 183
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 183
gguugcccug augagncgaa acccccc 27
＜210＞ 184
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 184
ucaaggucug augagncgaa agguugc 27
＜210＞ 185
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 185
gcagguccug augagncgaa aggugag 27
＜210＞ 186
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 186
uuugugucug augagncgaa aguggcc 27
＜210＞ 187
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 187
uuuugugcug augagncgaa aaguggc 27
＜210＞ 188
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 188
uggcccccug augagncgaa agccaca 27
＜210＞ 189
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 189
agguguucug augagncgaa accaugg 27
＜210＞ 190
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 190
uaggugucug augagncgaa aaccaug 27
＜210＞ 191
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 191
ccuuaaacug augagncgaa augguaa 27
＜210＞ 192
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 192
aaccuuacug augagncgaa agauggu 27
＜210＞ 193
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 193
cagcacucug augagncgaa agccugu 27
＜210＞ 194
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 194
gcagcaccug augagncgaa aagccug 27
＜210＞ 195
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 195
aggucgccug augagncgaa acgcucu 27
＜210＞ 196
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 196
gagcucccug augagncgaa aucuguc 27
＜210＞ 197
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 197
gcgggcucug augagncgaa agcuccg 27
＜210＞ 198
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 198
ugucgugcug augagncgaa acagcag 27
＜210＞ 199
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 199
ucugaugcug augagncgaa aggugga 27
＜210＞ 200
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 200
auguucucug augagncgaa auggagg 27
＜210＞ 201
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 201
cguccaccug augagncgaa auguucu 27
＜210＞ 202
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 202
aggcacacug augagncgaa acgcgcg 27
＜210＞ 203
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 203
gguucuccug augagncgaa agggcgg 27
＜210＞ 204
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 204
cguugagcug augagncgaa accacca 27
＜210＞ 205
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 205
ccgcguucug augagncgaa aggacca 27
＜210＞ 206
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 206
cuugaugcug augagncgaa accaggc 27
＜210＞ 207
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 207
ugcccuucug augagncgaa auguacc 27
＜210＞ 208
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 208
ccccaggcug augagncgaa accagcc 27
＜210＞ 209
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 209
cagagcacug augagncgaa augccgc 27
＜210＞ 210
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 210
ccguacacug augagncgaa agcauau 27
＜210＞ 211
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 211
cacgccgcug augagncgaa acagagc 27
＜210＞ 212
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 212
ccagcagcug augagncgaa agcagga 27
＜210＞ 213
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 213
auggcgucug augagncgaa agcccgu 27
＜210＞ 214
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 214
cauggcgcug augagncgaa aagcccg 27
＜210＞ 215
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 215
guauugucug augagncgaa accacca 27
＜210＞ 216
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 216
aguauugcug augagncgaa aaccacc 27
＜210＞ 217
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 217
gauaaagcug augagncgaa auuguaa 27
＜210＞ 218
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 218
ggugauacug augagncgaa aguauug 27
＜210＞ 219
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 219
uggugaucug augagncgaa aaguauu 27
＜210＞ 220
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 220
acgcacacug augagncgaa augcgcc 27
＜210＞ 221
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 221
cacgcaccug augagncgaa aaugcgc 27
＜210＞ 222
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 222
gagggggcug augagncgaa acccaca 27
＜210＞ 223
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 223
acauugacug augagncgaa agggggg 27
＜210＞ 224
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 224
ggacauucug augagncgaa agagggg 27
＜210＞ 225
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 225
ccccccgcug augagncgaa acauuga 27
＜210＞ 226
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 226
aggaugacug augagncgaa agcaucg 27
＜210＞ 227
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 227
ggaggaucug augagncgaa auagcau 27
＜210＞ 228
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 228
ugaggagcug augagncgaa augauag 27
＜210＞ 229
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 229
augugagcug augagncgaa aggauga 27
＜210＞ 230
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 230
cacaugucug augagncgaa aggagga 27
＜210＞ 231
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 231
ucgcagucug augagncgaa auggcag 27
＜210＞ 232
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 232
uggacgucug augagncgaa auggccu 27
＜210＞ 233
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 233
uuggacgcug augagncgaa aauggcc 27
＜210＞ 234
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 234
ccauuugcug augagncgaa acguaau 27
＜210＞ 235
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 235
cuucaugcug augagncgaa aggccau 27
＜210＞ 236
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 236
gcuucaucug augagncgaa aaggcca 27
＜210＞ 237
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 237
aauccugcug augagncgaa agcgggg 27
＜210＞ 238
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 238
ugggccccug augagncgaa auccugu 27
＜210＞ 239
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 239
ggucucgcug augagncgaa aggcccg 27
＜210＞ 240
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 240
ccaccgccug augagncgaa aggucuc 27
＜210＞ 241
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 241
agaagaccug augagncgaa acgggcu 27
＜210＞ 242
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 242
cagagaacug augagncgaa acgacgg 27
＜210＞ 243
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 243
gucagagcug augagncgaa agacgac 27
＜210＞ 244
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 244
aggugaucug augagncgaa aucuugg 27
＜210＞ 245
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 245
cccaggucug augagncgaa augaucu 27
＜210＞ 246
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 246
ccaagaucug augagncgaa auguccc 27
＜210＞ 247
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 247
gucccaacug augagncgaa augaugu 27
＜210＞ 248
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 248
caguccccug augagncgaa agaugau 27
＜210＞ 249
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 249
gggcggacug augagncgaa acgggca 27
＜210＞ 250
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 250
ucgggcgcug augagncgaa agacggg 27
＜210＞ 251
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 251
ccagaagcug augagncgaa aucuccc 27
＜210＞ 252
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 252
gggcaagcug augagncgaa agucgcc 27
＜210＞ 253
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 253
ugggggccug augagncgaa aggaguc 27
＜210＞ 254
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 254
aggccgucug augagncgaa auggggg 27
＜210＞ 255
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 255
ggccugucug augagncgaa aggcuag 27
＜210＞ 256
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 256
ccacuugcug augagncgaa accuccc 27
＜210＞ 257
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 257
accacuucug augagncgaa aaccucc 27
＜210＞ 258
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 258
cgguggacug augagncgaa accacuu 27
＜210＞ 259
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 259
gcgguggcug augagncgaa aaccacu 27
＜210＞ 260
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 260
ugcggugcug augagncgaa aaaccac 27
＜210＞ 261
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 261
acggucccug augagncgaa acacaca 27
＜210＞ 262
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 262
ggucuuucug augagncgaa agccggc 27
＜210＞ 263
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 263
ggccggccug augagncgaa agggucu 27
＜210＞ 264
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 264
gccccggcug augagncgaa aggcgca 27
＜210＞ 265
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 265
guaagggcug augagncgaa acgcgcc 27
＜210＞ 266
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 266
uguaaggcug augagncgaa aacgcgc 27
＜210＞ 267
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 267
auggugucug augagncgaa agggaac 27
＜210＞ 268
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 268
cauggugcug augagncgaa aagggaa 27
＜210＞ 269
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 269
gaggucccug augagncgaa agcuacc 27
＜210＞ 270
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 270
ccagauacug augagncgaa agguccg 27
＜210＞ 271
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 271
gaccagacug augagncgaa agagguc 27
＜210＞ 272
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 272
gugaccacug augagncgaa auagagg 27
＜210＞ 273
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 273
gucucgucug augagncgaa accagau 27
＜210＞ 274
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 274
gcaccggcug augagncgaa augacgu 27
＜210＞ 275
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 275
cgcaccgcug augagncgaa aaugacg 27
＜210＞ 276
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 276
cuccccccug augagncgaa accguca 27
＜210＞ 277
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 277
gggacagcug augagncgaa aggcucc 27
＜210＞ 278
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 278
ucuggggcug augagncgaa acaguag 27
＜210＞ 279
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 279
gccaccccug augagncgaa aagagcc 27
＜210＞ 280
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 280
aagggcacug augagncgaa agcagug 27
＜210＞ 281
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 281
ugccccgcug augagncgaa agggcag 27
＜210＞ 282
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 282
gugcccccug augagncgaa aagggca 27
＜210＞ 283
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 283
agaugcccug augagncgaa acagcgu 27
＜210＞ 284
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 284
cccggaacug augagncgaa augccua 27
＜210＞ 285
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 285
agcccggcug augagncgaa agaugcc 27
＜210＞ 286
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 286
cagcccgcug augagncgaa aagaugc 27
＜210＞ 287
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 287
ccuucgccug augagncgaa acccccc 27
＜210＞ 288
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 288
ggcacuucug augagncgaa agugcuc 27
＜210＞ 289
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 289
ggcugcgcug augagncgaa acgcagc 27
＜210＞ 290
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 290
uaccuugcug augagncgaa acccuug 27
＜210＞ 291
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 291
uggcggccug augagncgaa acagaug 27
＜210＞ 292
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 292
caguucucug augagncgaa auguugg 27
＜210＞ 293
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 293
ugguccucug augagncgaa accccag 27
＜210＞ 294
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 294
cuuaccacug augagncgaa aggugga 27
＜210＞ 295
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 295
aggaacucug augagncgaa accauag 27
＜210＞ 296
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 296
ggcaaggcug augagncgaa acuuacc 27
＜210＞ 297
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 297
cggcaagcug augagncgaa aacuuac 27
＜210＞ 298
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 298
cgucggccug augagncgaa aggaacu 27
＜210＞ 299
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 299
cacauaucug augagncgaa augauau 27
＜210＞ 300
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 300
caucacacug augagncgaa auuauga 27
＜210＞ 301
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 301
gguccagcug augagncgaa acugugc 27
＜210＞ 302
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 302
gcacgaccug augagncgaa agccgcg 27
＜210＞ 303
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 303
cgagcaccug augagncgaa acgagcc 27
＜210＞ 304
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 304
cgguggccug augagncgaa agcacga 27
＜210＞ 305
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 305
uccucaacug augagncgaa auuuggg 27
＜210＞ 306
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 306
aguguugcug augagncgaa acagagc 27
＜210＞ 307
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 307
agaagggcug augagncgaa aucucuc 27
＜210＞ 308
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 308
cgaggggcug augagncgaa auggccu 27
＜210＞ 309
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 309
uggccuccug augagncgaa aggggga 27
＜210＞ 310
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 310
cccccuucug augagncgaa auggccu 27
＜210＞ 311
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 311
cuucuugcug augagncgaa aguggca 27
＜210＞ 312
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 312
cggcauucug augagncgaa auuccga 27
＜210＞ 313
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 313
aauacgccug augagncgaa acggcau 27
＜210＞ 314
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 314
ccgguaacug augagncgaa acgcuac 27
＜210＞ 315
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 315
ccccggucug augagncgaa auacgcu 27
＜210＞ 316
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 316
accccggcug augagncgaa aauacgc 27
＜210＞ 317
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 317
ucgguaucug augagncgaa acggaca 27
＜210＞ 318
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 318
uagucggcug augagncgaa augacgg 27
＜210＞ 319
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 319
ucuccgccug augagncgaa agucggu 27
＜210＞ 320
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 320
accggugcug augagncgaa agcccgu 27
＜210＞ 321
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 321
ugcaguccug augagncgaa aucaccg 27
＜210＞ 322
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 322
ugagcgccug augagncgaa acaccgc 27
＜210＞ 323
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 323
ccguugucug augagncgaa agcgcga 27
＜210＞ 324
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 324
ucauacccug augagncgaa agcacag 27
＜210＞ 325
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 325
gagcucacug augagncgaa accaagc 27
＜210＞ 326
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 326
cgggcgucug augagncgaa agcucau 27
＜210＞ 327
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 327
cugacugcug augagncgaa agucuca 27
＜210＞ 328
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 328
gcaaccucug augagncgaa acuguag 27
＜210＞ 329
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 329
agcccgccug augagncgaa accugac 27
＜210＞ 330
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 330
uucaggucug augagncgaa agcccgc 27
＜210＞ 331
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 331
auucaggcug augagncgaa aagcccg 27
＜210＞ 332
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 332
ccuggugcug augagncgaa auucagg 27
＜210＞ 333
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 333
gacgggccug augagncgaa acccugg 27
＜210＞ 334
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 334
ccuggcacug augagncgaa acgggca 27
＜210＞ 335
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 335
aacuccacug augagncgaa auggucc 27
＜210＞ 336
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 336
gguaugccug augagncgaa accaggu 27
＜210＞ 337
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 337
ggcuuggcug augagncgaa augcuac 27
＜210＞ 338
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 338
ggagccucug augagncgaa agcccug 27
＜210＞ 339
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 339
uagccuacug augagncgaa acagcag 27
＜210＞ 340
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 340
ccuagcccug augagncgaa auacagc 27
＜210＞ 341
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 341
uagugaccug augagncgaa accucca 27
＜210＞ 342
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 342
ugcuagucug augagncgaa acgaccu 27
＜210＞ 343
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 343
caggugccug augagncgaa agugacg 27
＜210＞ 344
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 344
cuccgcccug augagncgaa accagca 27
＜210＞ 345
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 345
cugcaagcug augagncgaa acuccgc 27
＜210＞ 346
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 346
gagcugccug augagncgaa aggacuc 27
＜210＞ 347
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 347
caggcaacug augagncgaa augcggc 27
＜210＞ 348
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 348
gucaggccug augagncgaa auaugcg 27
＜210＞ 349
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 349
accacaccug augagncgaa accgguu 27
＜210＞ 350
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 350
acaaaaucug augagncgaa auccuac 27
＜210＞ 351
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 351
cgggaaccug augagncgaa acagccg 27
＜210＞ 352
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 352
ugucgggcug augagncgaa acaacag 27
＜210＞ 353
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 353
cugucggcug augagncgaa aacaaca 27
＜210＞ 354
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 354
cugcuugcug augagncgaa acugcuc 27
＜210＞ 355
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 355
ucugcuucug augagncgaa aacugcu 27
＜210＞ 356
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 356
accacggcug augagncgaa agcagcg 27
＜210＞ 357
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 357
ccaccugcug augagncgaa acuccac 27
＜210＞ 358
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 358
aggccuccug augagncgaa agggccc 27
＜210＞ 359
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 359
ugcccagcug augagncgaa aggccuc 27
＜210＞ 360
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 360
uugcccacug augagncgaa aaggccu 27
＜210＞ 361
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 361
aguggaucug augagncgaa agccugc 27
＜210＞ 362
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 362
gaguggacug augagncgaa aagccug 27
＜210＞ 363
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 363
gauguugcug augagncgaa acaggag 27
＜210＞ 364
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 364
agauguucug augagncgaa aacagga 27
＜210＞ 365
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 365
gaggagccug augagncgaa aguugag 27
＜210＞ 366
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 366
cugggagcug augagncgaa agcgagu 27
＜210＞ 367
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 367
gaaggcccug augagncgaa aagcagc 27
＜210＞ 368
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 368
gcccacgcug augagncgaa aggccga 27
＜210＞ 369
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 369
cgcccaccug augagncgaa aaggccg 27
＜210＞ 370
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 370
caccggccug augagncgaa augccgg 27
＜210＞ 371
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 371
ugcugcccug augagncgaa auggccg 27
＜210＞ 372
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 372
caaggcccug augagncgaa augcugc 27
＜210＞ 373
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 373
ccuuccccug augagncgaa aggccua 27
＜210＞ 374
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 374
cgcuccacug augagncgaa agcccgc 27
＜210＞ 375
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 375
aagccaccug augagncgaa agugcac 27
＜210＞ 376
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 376
accuuaacug augagncgaa agccacg 27
＜210＞ 377
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 377
gaccuuacug augagncgaa aagccac 27
＜210＞ 378
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 378
ugaccuucug augagncgaa aaagcca 27
＜210＞ 379
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 379
augaccucug augagncgaa aaaagcc 27
＜210＞ 380
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 380
cgcucaucug augagncgaa accuuaa 27
＜210＞ 381
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 381
cucggcgcug augagncgaa agggcgc 27
＜210＞ 382
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 382
gcaaguucug augagncgaa accaggu 27
＜210＞ 383
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 383
agcaagucug augagncgaa aaccagg 27
＜210＞ 384
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 384
uggcaggcug augagncgaa agcaagu 27
＜210＞ 385
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 385
gccggggcug augagncgaa agaggau 27
＜210＞ 386
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 386
ccccgaccug augagncgaa accaggg 27
＜210＞ 387
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 387
cgacccccug augagncgaa acgacca 27
＜210＞ 388
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 388
cacacaccug augagncgaa accccga 27
＜210＞ 389
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 389
gacgcagcug augagncgaa auugcug 27
＜210＞ 390
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 390
acgugcccug augagncgaa acgcagg 27
＜210＞ 391
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 391
cgaagcgcug augagncgaa acgcuau 27
＜210＞ 392
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 392
gcgaagccug augagncgaa aacgcua 27
＜210＞ 393
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 393
ccccgcgcug augagncgaa agcgaac 27
＜210＞ 394
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 394
uuugcaucug augagncgaa augccgu 27
＜210＞ 395
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 395
ccuggaacug augagncgaa aguucgg 27
＜210＞ 396
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 396
gcccuggcug augagncgaa auaguuc 27
＜210＞ 397
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 397
cgcccugcug augagncgaa aauaguu 27
＜210＞ 398
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 398
guaguggcug augagncgaa agucccc 27
＜210＞ 399
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 399
cguagugcug augagncgaa aaguccc 27
＜210＞ 400
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 400
cgucacgcug augagncgaa aguggaa 27
＜210＞ 401
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 401
ggcauuucug augagncgaa acguugu 27
＜210＞ 402
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 402
ggugaagcug augagncgaa auucggg 27
＜210＞ 403
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 403
cggugaacug augagncgaa aauucgg 27
＜210＞ 404
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 404
uucggugcug augagncgaa agaauuc 27
＜210＞ 405
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 405
auucggucug augagncgaa aagaauu 27
＜210＞ 406
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 406
cccgucccug augagncgaa auucggu 27
＜210＞ 407
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 407
ccugugccug augagncgaa accgcac 27
＜210＞ 408
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 408
cggagcgcug augagncgaa accugug 27
＜210＞ 409
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 409
cacgccgcug augagncgaa agcguac 27
＜210＞ 410
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 410
cguaggacug augagncgaa aggucug 27
＜210＞ 411
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 411
cccguagcug augagncgaa agagguc 27
＜210＞ 412
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 412
ccucccgcug augagncgaa aggagag 27
＜210＞ 413
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 413
ggaaugucug augagncgaa acauccu 27
＜210＞ 414
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 414
cgaccugcug augagncgaa aauguga 27
＜210＞ 415
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 415
ugagccccug augagncgaa accugga 27
＜210＞ 416
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 416
auugguucug augagncgaa agcccga 27
＜210＞ 417
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 417
aaccaggcug augagncgaa auugguu 27
＜210＞ 418
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 418
gugaccccug augagncgaa accaggu 27
＜210＞ 419
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 419
gagcugucug augagncgaa acccaac 27
＜210＞ 420
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 420
cgcauggcug augagncgaa agcugug 27
＜210＞ 421
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 421
gccagcccug augagncgaa acguuua 27
＜210＞ 422
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 422
ggggggacug augagncgaa acccccu 27
＜210＞ 423
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 423
gagggggcug augagncgaa agacccc 27
＜210＞ 424
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 424
ggccaagcug augagncgaa agggggg 27
＜210＞ 425
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 425
gcuggcccug augagncgaa aggaggg 27
＜210＞ 426
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 426
agcugaacug augagncgaa agcuggc 27
＜210＞ 427
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 427
cgcagaccug augagncgaa auuggcu 27
＜210＞ 428
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 428
aggcgcacug augagncgaa acaauug 27
＜210＞ 429
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 429
gccacagcug augagncgaa agguugg 27
＜210＞ 430
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 430
ccgcucgcug augagncgaa agcgggu 27
＜210＞ 431
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 431
uccgcuccug augagncgaa aagcggg 27
＜210＞ 432
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 432
caacggacug augagncgaa acuuccc 27
＜210＞ 433
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 433
uaugggccug augagncgaa acgcggg 27
＜210＞ 434
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 434
gugcccacug augagncgaa augggca 27
＜210＞ 435
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 435
ggguugucug augagncgaa auccggg 27
＜210＞ 436
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 436
aggguugcug augagncgaa aauccgg 27
＜210＞ 437
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 437
ggacucucug augagncgaa acagugg 27
＜210＞ 438
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 438
aggacuccug augagncgaa aacagug 27
＜210＞ 439
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 439
uaguccgcug augagncgaa acuuuuc 27
＜210＞ 440
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 440
agggacgcug augagncgaa aguccgg 27
＜210＞ 441 ＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 441
ccggaggcug augagncgaa acguagu 27
＜210＞ 442
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 442
accgccgcug augagncgaa agggacg 27
＜210＞ 443
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 443
aggcggccug augagncgaa augggca 27
＜210＞ 444
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 444
cccguggcug augagncgaa aggcggc 27
＜210＞ 445
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 445
cacggugcug augagncgaa acucugu 27
＜210＞ 446
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 446
gucuuagcug augagncgaa agccagc 27
＜210＞ 447
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 447
aaagucucug augagncgaa aguagcc 27
＜210＞ 448
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 448
cugccgacug augagncgaa agucuua 27
＜210＞ 449
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 449
gcugccgcug augagncgaa aagucuu 27
＜210＞ 450
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 450
agcugcccug augagncgaa aaagucu 27
＜210＞ 451
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 451
ggccgaccug augagncgaa auccgga 27
＜210＞ 452
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 452
aacggcccug augagncgaa acgaucc 27
＜210＞ 453
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 453
cgcuguccug augagncgaa acggccg 27
＜210＞ 454
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 454
cauggagcug augagncgaa aguacga 27
＜210＞ 455
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 455
gggcaugcug augagncgaa aggagua 27
＜210＞ 456
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 456
cccccuccug augagncgaa agggggg 27
＜210＞ 457
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 457
ucgcugacug augagncgaa aucaggg 27
＜210＞ 458
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 458
cgucgcucug augagncgaa agaucag 27
＜210＞ 459
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 459
agaccaacug augagncgaa acccguc 27
＜210＞ 460
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 460
guagacccug augagncgaa agacccg 27
＜210＞ 461
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 461
cacgguacug augagncgaa accaaga 27
＜210＞ 462
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 462
cucacggcug augagncgaa agaccaa 27
＜210＞ 463
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 463
agcagaccug augagncgaa augucgu 27
＜210＞ 464
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 464
agcagcacug augagncgaa acgaugu 27
＜210＞ 465
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 465
ggacauucug augagncgaa agcagca 27
＜210＞ 466
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 466
uguguagcug augagncgaa acauuga 27
＜210＞ 467
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 467
acgcguucug augagncgaa augggca 27
＜210＞ 468
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 468
acugcggcug augagncgaa auguugu 27
＜210＞ 469
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 469
cguccagcug augagncgaa acuugca 27
＜210＞ 470
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 470
gucccggcug augagncgaa agugguc 27
＜210＞ 471
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 471
agaaguucug augagncgaa agccuua 27
＜210＞ 472
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 472
cuacggacug augagncgaa agaaguu 27
＜210＞ 473
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 473
uucuacgcug augagncgaa auagaag 27
＜210＞ 474
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 474
cuucuuccug augagncgaa acggaua 27
＜210＞ 475
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 475
aaauuuacug augagncgaa auuuggc 27
＜210＞ 476
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 476
ccaaauucug augagncgaa agauuug 27
＜210＞ 477
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 477
auagccacug augagncgaa auuuaga 27
＜210＞ 478
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 478
cauagcccug augagncgaa aauuuag 27
＜210＞ 479
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 479
ugccccacug augagncgaa agccaaa 27
＜210＞ 480
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 480
cggagcgcug augagncgaa auguggu 27
＜210＞ 481
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 481
ccacacgcug augagncgaa agcggau 27
＜210＞ 482
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 482
auacgaucug augagncgaa aggcgag 27
＜210＞ 483
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 483
aauacgacug augagncgaa aaggcga 27
＜210＞ 484
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 484
ggaauaccug augagncgaa auaaggc 27
＜210＞ 485
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 485
gaauccgcug augagncgaa acgagga 27
＜210＞ 486
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 486
guacuggcug augagncgaa auccgua 27
＜210＞ 487
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 487
aggagagcug augagncgaa acuggaa 27
＜210＞ 488
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 488
ugcccagcug augagncgaa agaguac 27
＜210＞ 489
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 489
ggaacuccug augagncgaa acccgcu 27
＜210＞ 490
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 490
caccaggcug augagncgaa acucaac 27
＜210＞ 491
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 491
ucaccagcug augagncgaa aacucaa 27
＜210＞ 492
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 492
uuucuuucug augagncgaa auuucca 27
＜210＞ 493
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 493
gcgacuucug augagncgaa auggccu 27
＜210＞ 494
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 494
cgugagccug augagncgaa acuuuau 27
＜210＞ 495
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 495
gcuccgucug augagncgaa agcgacu 27
＜210＞ 496
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 496
cgauguacug augagncgaa agccgcu 27
＜210＞ 497
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 497
cccgaugcug augagncgaa agagccg 27
＜210＞ 498
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 498
ggccccccug augagncgaa auguaga 27
＜210＞ 499
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 499
cggcgaucug augagncgaa accgcag 27
＜210＞ 500
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 500
ccggcgacug augagncgaa aaccgca 27
＜210＞ 501
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 501
caccggccug augagncgaa auaaccg 27
＜210＞ 502
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 502
ccgcagccug augagncgaa agucguc 27
＜210＞ 503
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 503
gcagcuccug augagncgaa acaggcc 27
＜210＞ 504
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 504
aguccugcug augagncgaa agcuuug 27
＜210＞ 505
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 505
cguucaccug augagncgaa agcaucg 27
＜210＞ 506
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 506
uaacgaccug augagncgaa aggucgu 27
＜210＞ 507
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 507
agauaaccug augagncgaa acaaggu 27
＜210＞ 508
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 508
cacagaucug augagncgaa acgacaa 27
＜210＞ 509
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 509
gggggcacug augagncgaa aguaccu 27
＜210＞ 510
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 510
caagucgcug augagncgaa auucugg 27
＜210＞ 511
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 511
guuggagcug augagncgaa agcauga 27
＜210＞ 512
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 512
cacguugcug augagncgaa aggagca 27
＜210＞ 513
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 513
uuugccgcug augagncgaa augcguc 27
＜210＞ 514
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 514
cccgugccug augagncgaa agggggg 27
＜210＞ 515
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 515
gggcgcacug augagncgaa acaugau 27
＜210＞ 516
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 516
ugcccaucug augagncgaa agguggg 27
＜210＞ 517
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 517
uugcccacug augagncgaa aaggugg 27
＜210＞ 518
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 518
gucaucacug augagncgaa aaucauc 27
＜210＞ 519
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 519
aagaagucug augagncgaa agucauc 27
＜210＞ 520
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 520
aucugaccug augagncgaa auccagg 27
＜210＞ 521
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 521
uagaucucug augagncgaa acaaucc 27
＜210＞ 522
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 522
ccccguacug augagncgaa aucugac 27
＜210＞ 523
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 523
ggccccgcug augagncgaa agaucug 27
＜210＞ 524
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 524
guuuccucug augagncgaa aggcaug 27
＜210＞ 525
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 525
guacccccug augagncgaa aguuucc 27
＜210＞ 526
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 526
agggcggcug augagncgaa accccaa 27
＜210＞ 527
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 527
gacucgccug augagncgaa agggcgg 27
＜210＞ 528
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 528
gucuccacug augagncgaa acucgca 27
＜210＞ 529
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 529
uagcgcgcug augagncgaa acacuuc 27
＜210＞ 530
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 530
aguagcccug augagncgaa agcgcgg 27
＜210＞ 531
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 531
gggacagcug augagncgaa agccuag 27
＜210＞ 532
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 532
cccuuggcug augagncgaa acaguag 27
＜210＞ 533
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 533
cagcuggcug augagncgaa acgcggc 27
＜210＞ 534
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 534
gcuggaccug augagncgaa aguccag 27
＜210＞ 535
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 535
ccagcugcug augagncgaa acaaguc 27
＜210＞ 536
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 536
agcaacgcug augagncgaa accagcu 27
＜210＞ 537
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 537
cagcaaccug augagncgaa aaccagc 27
＜210＞ 538
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 538
aaccagccug augagncgaa acgaacc 27
＜210＞ 539
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 539
ugugauacug augagncgaa augucuc 27
＜210＞ 540
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 540
gcugugacug augagncgaa auauguc 27
＜210＞ 541
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 541
aggcugucug augagncgaa auauaug 27
＜210＞ 542
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 542
ggcacgacug augagncgaa acaggcu 27
＜210＞ 543
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 543
guaggagcug augagncgaa aggcacc 27
＜210＞ 544
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 544
aaaguagcug augagncgaa aguaggc 27
＜210＞ 545
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 545
cggaaagcug augagncgaa aggagua 27
＜210＞ 546
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 546
cuacggacug augagncgaa aguagga 27
＜210＞ 547
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 547
ccuacggcug augagncgaa aaguagg 27
＜210＞ 548
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 548
cccuacgcug augagncgaa aaaguag 27
＜210＞ 549
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 549
cuacccccug augagncgaa acggaaa 27
＜210＞ 550
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 550
agaugcccug augagncgaa accccua 27
＜210＞ 551
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 551
gcagguacug augagncgaa augccua 27
＜210＞ 552
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 552
gagcaggcug augagncgaa agaugcc 27
＜210＞ 553
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 553
gguugggcug augagncgaa agcaggu 27
＜210＞ 554
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 554
gagugaucug augagncgaa agcuccc 27
＜210＞ 555
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 555
cuggagucug augagncgaa auuagcu 27
＜210＞ 556
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 556
uggccugcug augagncgaa agugauu 27
＜210＞ 557
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 557
gauggcccug augagncgaa auuggcc 27
＜210＞ 558
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 558
cgacacucca ccaua 15
＜210＞ 559
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 559
gcagccucca ggacc 15
＜210＞ 560
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 560
ccccccuccc gggag 15
＜210＞ 561
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 561
uaguggucug cggaa 15
＜210＞ 562
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 562
ggugaguaca ccgga 15
＜210＞ 563
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 563
ccggaauugc cagga 15
＜210＞ 564
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 564
ccuuucuugg aucaa 15
＜210＞ 565
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 565
acccgcucaa ugccu 15
＜210＞ 566
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 566
gacugcuagc cgagu 15
＜210＞ 567
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 567
gccgaguagu guugg 15
＜210＞ 568
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 568
guaguguugg gucgc 15
＜210＞ 569
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 569
guugggucgc gaaag 15
＜210＞ 570
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 570
uugugguacu gccug 15
＜210＞ 571
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 571
gccugauagg gugcu 15
＜210＞ 572
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 572
gggugcuugc gagug 15
＜210＞ 573
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 573
gggaggucuc guaga 15
＜210＞ 574
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 574
gaggucucgu agacc 15
＜210＞ 575
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 575
gucucguaga ccgug 15
＜210＞ 576
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 576
aggacgucaa guucc 15
＜210＞ 577
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 577
gucaaguucc cgggc 15
＜210＞ 578
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 578
ucaaguuccc gggcg 15
＜210＞ 579
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 579
cgguggucag aucgu 15
＜210＞ 580
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 580
cccacguugg gugug 15
＜210＞ 581
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 581
cgcgacuagg aagac 15
＜210＞ 582
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 582
gaagacuucc gaacg 15
＜210＞ 583
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 583
aagacuuccg aacgg 15
＜210＞ 584
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 584
gaacggucgc aaccu 15
＜210＞ 585
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 585
acaaccuauc cccaa 15
＜210＞ 586
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 586
aaccuauccc caagg 15
＜210＞ 587
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 587
caaggcucgc cgacc 15
＜210＞ 588
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 588
cgaggguagg gccug 15
＜210＞ 589
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 589
cugggcucag ccugg 15
＜210＞ 590
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 590
ccuggguacc cuugg 15
＜210＞ 591
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 591
guacccuugg ccccu 15
＜210＞ 592
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 592
ggccccucua uggca 15
＜210＞ 593
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 593
ccccucuaug gcaau 15
＜210＞ 594
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 594
gauggcuccu gucac 15
＜210＞ 595
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 595
cuccugucac cccgc 15
＜210＞ 596
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 596
cgcggcuccc ggccu 15
＜210＞ 597
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 597
ccggccuagu ugggg 15
＜210＞ 598
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 598
gccuaguugg ggccc 15
＜210＞ 599
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 599
gcgcaaucug gguaa 15
＜210＞ 600
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 600
guaaggucau cgaua 15
＜210＞ 601
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 601
aggucaucga uaccc 15
＜210＞ 602
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 602
caucgauacc cucac 15
＜210＞ 603
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 603
ugcggcuucg ccgac 15
＜210＞ 604
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 604
gcggcuucgc cgacc 15
＜210＞ 605
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 605
augggguaca uuccg 15
＜210＞ 606
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 606
gguacauucc gcucg 15
＜210＞ 607
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 607
guacauuccg cucgu 15
＜210＞ 608
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 608
uuccgcucgu cggcg 15
＜210＞ 609
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 609
cgcucgucgg cgccc 15
＜210＞ 610
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 610
ccccccuagg gggcg 15
＜210＞ 611
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 611
augguguccg gguuc 15
＜210＞ 612
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 612
uccggguucu ggagg 15
＜210＞ 613
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 613
ccggguucug gagga 15
＜210＞ 614
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 614
gugaacuacg caaca 15
＜210＞ 615
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 615
gggaacuugc ccggu 15
＜210＞ 616
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 616
gcccgguugc ucuuu 15
＜210＞ 617
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 617
gguugcucuu ucucu 15
＜210＞ 618
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 618
auuguguaug aggca 15
＜210＞ 619
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 619
gcaugaucau gcaua 15
＜210＞ 620
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 620
ggugcguacc cugcg 15
＜210＞ 621
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 621
ccugcguucg ggaga 15
＜210＞ 622
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 622
cugcguucgg gagaa15
＜210＞ 623
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 623
aacgccuccc guugu 15
＜210＞ 624
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 624
cucccguugu ugggu 15
＜210＞ 625
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 625
ccguuguugg guagc 15
＜210＞ 626
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 626
guuggguagc gcuca 15
＜210＞ 627
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 627
gccacgucga cuugc 15
＜210＞ 628
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 628
gucgacuugc ucguu 15
＜210＞ 629
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 629
acuugcucgu ugggg 15
＜210＞ 630
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 630
ugcucguugg ggcgg 15
＜210＞ 631
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 631
gccgcuuucu guucc 15
＜210＞ 632
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 632
ccgcuuucug uuccg 15
＜210＞ 633
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 633
uuucuguucc gccau 15
＜210＞ 634
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 634
uucuguuccg ccaug 15
＜210＞ 635
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 635
gccauguacg ugggg 15
＜210＞ 636
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 636
ugcggauccg uuuuc 15
＜210＞ 637
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 637
gauccguuuu ccucg 15
＜210＞ 638
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 638
auccguuuuc cucgu 15
＜210＞ 639
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 639
uccguuuucc ucguc 15
＜210＞ 640
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 640
ccguuuuccu cgucu 15
＜210＞ 641
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 641
gccauguauc agguc 15
＜210＞ 642
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 642
cauguaucag gucac 15
＜210＞ 643
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 643
aucaggucac cgcau 15
＜210＞ 644
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 644
aagcugucgu ggaua 15
＜210＞ 645
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 645
cguggauaug guggc 15
＜210＞ 646
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 646
ggggaguccu agcgg 15
＜210＞ 647
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 647
gaguccuagc gggcc 15
＜210＞ 648
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 648
cgggccuugc cuacu 15
＜210＞ 649
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 649
cuugccuacu auucc 15
＜210＞ 650
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 650
gccuacuauu ccaug 15
＜210＞ 651
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 651
cuacuauucc auggu 15
＜210＞ 652
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 652
uacuauucca uggug 15
＜210＞ 653
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 653
gcuccaucga caagu 15
＜210＞ 654
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 654
gacaaguucg cucag 15
＜210＞ 655
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 655
acaaguucgc ucagg 15
＜210＞ 656
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 656
guucgcucag ggaug 15
＜210＞ 657
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 657
gccccaucac cuaua 15
＜210＞ 658
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 658
aucaccuaua ccgag 15
＜210＞ 659
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 659
aggccuuacu gcugg 15
＜210＞ 660
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 660
cuggcauuac gcacc 15
＜210＞ 661
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 661
uggcauuacg caccu 15
＜210＞ 662
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 662
cgcaccucgg cagug 15
＜210＞ 663
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 663
gugugguauc guacc 15
＜210＞ 664
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 664
gugguaucgu accug 15
＜210＞ 665
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 665
guaucguacc ugcgu 15
＜210＞ 666
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 666
ccugcgucgc aggug 15
＜210＞ 667
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 667
guguggucca gugua 15
＜210＞ 668
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 668
gcccuguugu agugg 15
＜210＞ 669
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 669
cuguuguagu gggga 15
＜210＞ 670
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 670
gaccgaucgg uccgg 15
＜210＞ 671
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 671
gaucgguccg gugcc 15
＜210＞ 672
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 672
ugccccuacg uauaa 15
＜210＞ 673
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 673
ccuacguaua acugg 15
＜210＞ 674
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 674
uacguauaac ugggg 15
＜210＞ 675
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 675
aacugguuug gcugu 15
＜210＞ 676
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 676
acugguuugg cugua 15
＜210＞ 677
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 677
uggcuguaca uggau 15
＜210＞ 678
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 678
gggcccuccg ugcaa 15
＜210＞ 679
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 679
gcaacaucgg ggggg 15
＜210＞ 680
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 680
ggggggucgg caacc 15
＜210＞ 681
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 681
gcaaccucac cuuga 15
＜210＞ 682
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 682
cucaccuuga ccugc 15
＜210＞ 683
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 683
ggccacuuac acaaa 15
＜210＞ 684
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 684
gccacuuaca caaaa 15
＜210＞ 685
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 685
uguggcucgg ggcca 15
＜210＞ 686
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 686
ccaugguuaa caccu 15
＜210＞ 687
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 687
caugguuaac accua 15
＜210＞ 688
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 688
uuaccaucuu uaagg 15
＜210＞ 689
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 689
accaucuuua agguu 15
＜210＞ 690
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 690
acaggcuuag ugcug 15
＜210＞ 691
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 691
caggcuuagu gcugc 15
＜210＞ 692
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 692
agagcguugc gaccu 15
＜210＞ 693
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 693
gacagaucgg agcuc 15
＜210＞ 694
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 694
cggagcucag cccgc 15
＜210＞ 695
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 695
cugcugucca cgaca 15
＜210＞ 696
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 696
uccaccucca ucaga 15
＜210＞ 697
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 697
ccuccaucag aacau 15
＜210＞ 698
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 698
agaacaucgu ggacg 15
＜210＞ 699
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 699
cgcgcgucug ugccu 15
＜210＞ 700
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 700
ccgcccuaga gaacc 15
＜210＞ 701
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 701
uggugguccu caacg 15
＜210＞ 702
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 702
ugguccucaa cgcgg 15
＜210＞ 703
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 703
gccugguaca ucaag 15
＜210＞ 704
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 704
gguacaucaa gggca 15
＜210＞ 705
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 705
ggcugguccc ugggg 15
＜210＞ 706
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 706
gcggcauaug cucug 15
＜210＞ 707
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 707
auaugcucug uacgg 15
＜210＞ 708
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 708
gcucuguacg gcgug 15
＜210＞ 709
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 709
uccugcuccu gcugg 15
＜210＞ 710
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 710
acgggcuuac gccau 15
＜210＞ 711
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 711
cgggcuuacg ccaug 15
＜210＞ 712
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 712
uggugguuac aauac 15
＜210＞ 713
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 713
ggugguuaca auacu 15
＜210＞ 714
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 714
uuacaauacu uuauc 15
＜210＞ 715
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 715
caauacuuua ucacc 15
＜210＞ 716
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 716
aauacuuuau cacca 15
＜210＞ 717
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 717
ggcgcauuug ugcgu 15
＜210＞ 718
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 718
gcgcauuugu gcgug 15
＜210＞ 719
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 719
uguggguccc cccuc 15
＜210＞ 720
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 720
ccccccucuc aaugu 15
＜210＞ 721
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 721
ccccucucaa ugucc 15
＜210＞ 722
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 722
ucaauguccg ggggg 15
＜210＞ 723
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 723
cgaugcuauc auccu 15
＜210＞ 724
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 724
augcuaucau ccucc 15
＜210＞ 725
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 725
cuaucauccu ccuca 15
＜210＞ 726
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 726
ucauccuccu cacau 15
＜210＞ 727
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 727
uccuccucac augug 15
＜210＞ 728
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 728
cugccauaac ugcga 15
＜210＞ 729
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 729
aggccauuac gucca 15
＜210＞ 730
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 730
ggccauuacg uccaa 15
＜210＞ 731
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 731
auuacgucca aaugg 15
＜210＞ 732
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 732
auggccuuca ugaag 15
＜210＞ 733
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 733
uggccuucau gaagc 15
＜210＞ 734
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 734
ccccgcuaca ggauu 15
＜210＞ 735
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 735
acaggauugg gccca 15
＜210＞ 736
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 736
cgggccuacg agacc 15
＜210＞ 737
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 737
gagaccuugc ggugg 15
＜210＞ 738
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 738
agcccgucgu cuucu 15
＜210＞ 739
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 739
ccgucgucuu cucug 15
＜210＞ 740
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 740
gucgucuucu cugac 15
＜210＞ 741
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 741
ccaagaucau caccu 15
＜210＞ 742
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 742
agaucaucac cuggg 15
＜210＞ 743
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 743
gggacaucau cuugg 15
＜210＞ 744
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 744
acaucaucuu gggac 15
＜210＞ 745
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 745
aucaucuugg gacug 15
＜210＞ 746
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 746
ugcccgucuc cgccc 15
＜210＞ 747
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 747
cccgucuccg cccga 15
＜210＞ 748
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 748
gggagauacu ucugg 15
＜210＞ 749
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 749
ggcgacuccu ugccc 15
＜210＞ 750
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 750
gacuccuugc cccca 15
＜210＞ 751
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 751
cccccaucac ggccu 15
＜210＞ 752
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 752
cuagccucac aggcc 15
＜210＞ 753
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 753
gggagguuca agugg 15
＜210＞ 754
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 754
ggagguucaa guggu 15
＜210＞ 755
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 755
aagugguuuc caccg 15
＜210＞ 756
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 756
agugguuucc accgc 15
＜210＞ 757
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 757
gugguuucca ccgca 15
＜210＞ 758
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 758
uguguguugg accgu 15
＜210＞ 759
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 759
gccggcucaa agacc 15
＜210＞ 760
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 760
agacccuagc cggcc 15
＜210＞ 761
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 761
ugcgccuccc ggggc 15
＜210＞ 762
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 762
ggcgcguucc cuuac 15
＜210＞ 763
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 763
gcgcguuccc uuaca 15
＜210＞ 764
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 764
guucccuuac accau 15
＜210＞ 765
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 765
uucccuuaca ccaug 15
＜210＞ 766
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus ＜400＞ 766
gguagcucgg accuc 15
＜210＞ 767
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 767
cggaccucua ucugg 15
＜210＞ 768
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 768
gaccucuauc ugguc 15
＜210＞ 769
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 769
ccucuaucug gucac 15
＜210＞ 770
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 770
aucuggucac gagac 15
＜210＞ 771
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 771
acgucauucc ggugc 15
＜210＞ 772
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 772
cgucauuccg gugcg 15
＜210＞ 773
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 773
ugacggucgg gggag 15
＜210＞ 774
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 774
ggagccuacu guccc 15
＜210＞ 775
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 775
cuacuguccc ccaga 15
＜210＞ 776
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 776
ggcucuucgg guggc 15
＜210＞ 777
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 777
cacugcucug cccuu 15
＜210＞ 778
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 778
cugcccuucg gggca 15
＜210＞ 779
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 779
ugcccuucgg ggcac 15
＜210＞ 780
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 780
acgcuguagg caucu 15
＜210＞ 781
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 781
uaggcaucuu ccggg 15
＜210＞ 782
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 782
ggcaucuucc gggcu 15
＜210＞ 783
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 783
gcaucuuccg ggcug 15
＜210＞ 784
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 784
gggggguugc gaagg 15
＜210＞ 785
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 785
gagcacuaaa gugcc 15
＜210＞ 786
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 786
gcugcguacg cagcc 15
＜210＞ 787
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 787
caaggguaca aggua 15
＜210＞ 788
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 788
caucuguugc cgcca 15
＜210＞ 789
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 789
ccaacaucag aacug 15
＜210＞ 790
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 790
cugggguaag gacca 15
＜210＞ 791
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 791
uccaccuaug guaag 15
＜210＞ 792
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 792
cuaugguaag uuccu 15
＜210＞ 793
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 793
gguaaguucc uugcc 15
＜210＞ 794
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 794
guaaguuccu ugccg 15
＜210＞ 795
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 795
aguuccuugc cgacg 15
＜210＞ 796
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 796
auaucauaau augug 15
＜210＞ 797
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 797
ucauaauaug ugaug 15
＜210＞ 798
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 798
gcacaguccu ggacc 15
＜210＞ 799
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 799
cgcggcucgu cgugc 15
＜210＞ 800
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 800
ggcucgucgu gcucg 15
＜210＞ 801
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 801
ucgugcucgc caccg 15
＜210＞ 802
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 802
cccaaauauu gagga 15
＜210＞ 803
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 803
gcucugucca acacu 15
＜210＞ 804
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 804
gagagauccc cuucu 15
＜210＞ 805
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 805
aggccauccc ccucg 15
＜210＞ 806
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 806
ucccccucga ggcca 15
＜210＞ 807
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 807
aggccaucaa ggggg 15
＜210＞ 808
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 808
ugccacucca agaag 15
＜210＞ 809
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 809
ucggaaucaa ugccg 15
＜210＞ 810
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 810
augccguagc guauu 15
＜210＞ 811
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 811
guagcguauu accgg 15
＜210＞ 812
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 812
agcguauuac cgggg 15
＜210＞ 813
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 813
gcguauuacc ggggu 15
＜210＞ 814
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 814
uguccgucau accga 15
＜210＞ 815
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 815
ccgucauacc gacua 15
＜210＞ 816
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 816
accgacuagc ggaga 15
＜210＞ 817
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 817
acgggcuaca ccggu 15
＜210＞ 818
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 818
cggugaucga cugca 15
＜210＞ 819
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 819
gcggugucgc gcuca 15
＜210＞ 820
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 820
ucgcgcucac aacgg 15
＜210＞ 821
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 821
cugugcuugg uauga 15
＜210＞ 822
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 822
gcuugguaug agcuc 15
＜210＞ 823
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 823
augagcucac gcccg 15
＜210＞ 824
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 824
ugagacuaca gucag 15
＜210＞ 825
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 825
cuacagucag guugc 15
＜210＞ 826
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 826
gucagguugc gggcu 15
＜210＞ 827
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 827
gcgggcuuac cugaa 15
＜210＞ 828
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 828
cgggcuuacc ugaau 15
＜210＞ 829
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 829
ccugaauaca ccagg 15
＜210＞ 830
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 830
ccaggguugc ccguc 15
＜210＞ 831
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 831
ugcccgucug ccagg 15
＜210＞ 832
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 832
ggaccaucug gaguu 15
＜210＞ 833
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 833
accugguagc auacc 15
＜210＞ 834
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 834
guagcauacc aagcc 15
＜210＞ 835
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 835
cagggcucag gcucc 15
＜210＞ 836
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 836
cugcuguaua ggcua 15
＜210＞ 837
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 837
gcuguauagg cuagg 15
＜210＞ 838
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 838
uggaggucgu cacua 15
＜210＞ 839
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 839
aggucgucac uagca 15
＜210＞ 840
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 840
cgucacuagc accug 15
＜210＞ 841
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 841
ugcugguagg cggag 15
＜210＞ 842
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 842
gcggaguccu ugcag 15
＜210＞ 843
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 843
gaguccuugc agcuc 15
＜210＞ 844
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 844
gccgcauauu gccug 15
＜210＞ 845
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 845
cgcauauugc cugac 15
＜210＞ 846
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 846
aaccgguagu guggu 15
＜210＞ 847
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 847
guaggaucau uuugu 15
＜210＞ 848
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 848
cggcuguugu ucccg 15
＜210＞ 849
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 849
cuguuguucc cgaca 15
＜210＞ 850
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 850
uguuguuccc gacag 15
＜210＞ 851
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 851
gagcaguuca agcag 15
＜210＞ 852
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 852
agcaguucaa gcaga 15
＜210＞ 853
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 853
cgcugcuccc guggu 15
＜210＞ 854
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 854
guggagucca ggugg 15
＜210＞ 855
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 855
gggcccuuga ggccu 15
＜210＞ 856
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 856
gaggccuucu gggca 15
＜210＞ 857
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 857
aggccuucug ggcaa 15
＜210＞ 858
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 858
gcaggcuuau ccacu 15
＜210＞ 859
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 859
caggcuuauc cacuc 15
＜210＞ 860
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 860
cuccuguuca acauc 15
＜210＞ 861
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 861
uccuguucaa caucu 15
＜210＞ 862
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 862
cucaacucgc uccuc 15
＜210＞ 863
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 863
acucgcuccu cccag 15
＜210＞ 864
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 864
gcugcuucgg ccuuc 15
＜210＞ 865
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 865
ucggccuucg ugggc 15
＜210＞ 866
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 866
cggccuucgu gggcg 15
＜210＞ 867
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 867
ccggcauugc cggug 15
＜210＞ 868
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 868
cggccauugg cagca 15
＜210＞ 869
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 869
gcagcauagg ccuug 15
＜210＞ 870
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 870
uaggccuugg gaagg 15
＜210＞ 871
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 871
gcgggcuaug gagcg 15
＜210＞ 872
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 872
gugcacucgu ggcuu 15
＜210＞ 873
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 873
cguggcuuuu aaggu 15
＜210＞ 874
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 874
guggcuuuua agguc 15
＜210＞ 875
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 875
uggcuuuuaa gguca 15
＜210＞ 876
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 876
ggcuuuuaag gucau 15
＜210＞ 877
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 877
uuaaggucau gagcg 15
＜210＞ 878
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 878
gcgcccuccg ccgag 15
＜210＞ 879
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 879
accugguuaa cuugc 15
＜210＞ 880
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 880
ccugguuaac uugcu 15
＜210＞ 881
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 881
acuugcuccc ugcca 15
＜210＞ 882
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 882
auccucuccc ccggc 15
＜210＞ 883
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 883
cccuggucgu cgggg 15
＜210＞ 884
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 884
uggucgucgg ggucg 15
＜210＞ 885
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 885
ucggggucgu gugug 15
＜210＞ 886
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 886
cagcaauccu gcguc 15
＜210＞ 887
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 887
ccugcgucgg cacgu 15
＜210＞ 888
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 888
auagcguucg cuucg 15
＜210＞ 889
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 889
uagcguucgc uucgc 15
＜210＞ 890
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 890
guucgcuucg cgggg 15
＜210＞ 891
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 891
acggcaucau gcaaa 15
＜210＞ 892
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 892
ccgaacuauu ccagg 15
＜210＞ 893
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 893
gaacuauucc agggc 15
＜210＞ 894
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 894
aacuauucca gggcg 15
＜210＞ 895
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 895
ggggacuucc acuac 15
＜210＞ 896
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 896
gggacuucca cuacg 15
＜210＞ 897
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 897
uuccacuacg ugacg 15
＜210＞ 898
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 898
acaacguaaa augcc 15
＜210＞ 899
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 899
cccgaauucu ucacc 15
＜210＞ 900
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 900
ccgaauucuu caccg 15
＜210＞ 901
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 901
gaauucuuca ccgaa 15
＜210＞ 902
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 902
aauucuucac cgaau 15
＜210＞ 903
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 903
accgaauugg acggg 15
＜210＞ 904
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 904
gugcgguugc acagg 15
＜210＞ 905
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 905
cacagguacg cuccg 15
＜210＞ 906
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 906
guacgcuccg gcgug 15
＜210＞ 907
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 907
cagaccucuc cuacg 15
＜210＞ 908
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 908
gaccucuccu acggg 15
＜210＞ 909
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 909
cucuccuacg ggagg 15
＜210＞ 910
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 910
aggaugucac auucc 15
＜210＞ 911
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 911
ucacauucca ggucg 15
＜210＞ 912
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 912
uccaggucgg gcuca 15
＜210＞ 913
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 913
ucgggcucaa ccaau 15
＜210＞ 914
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 914
aaccaauacc ugguu 15
＜210＞ 915
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 915
accugguugg gucac 15
＜210＞ 916
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 916
guugggucac agcuc 15
＜210＞ 917
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 917
cacagcuccc augcg 15
＜210＞ 918
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 918
uaaacguagg cuggc 15
＜210＞ 919
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 919
agggggucuc ccccc 15
＜210＞ 920
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 920
ggggucuccc cccuc 15
＜210＞ 921
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 921
ccccccuccu uggcc 15
＜210＞ 922
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 922
cccuccuugg ccagc 15
＜210＞ 923
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 923
gccagcucuu cagcu 15
＜210＞ 924
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 924
agccaauugu cugcg 15
＜210＞ 925
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 925
caauugucug cgccu 15
＜210＞ 926
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 926
ccaaccuccu guggc 15
＜210＞ 927
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 927
acccgcuucg agcgg 15
＜210＞ 928
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 928
cccgcuucga gcgga 15
＜210＞ 929
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 929
gggaaguauc cguug 15
＜210＞ 930
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 930
cccgcguugc ccaua 15
＜210＞ 931
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 931
ugcccauaug ggcac 15
＜210＞ 932
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 932
cccggauuac aaccc 15
＜210＞ 933
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 933
ccggauuaca acccu 15
＜210＞ 934
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 934
ccacuguuag agucc 15
＜210＞ 935
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 935
cacuguuaga guccu 15
＜210＞ 936
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 936
gaaaaguccg gacua 15
＜210＞ 937
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 937
ccggacuacg ucccu 15
＜210＞ 938
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 938
acuacguccc uccgg 15
＜210＞ 939
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 939
cgucccuccg gcggu 15
＜210＞ 940
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 940
ugcccauugc cgccu 15
＜210＞ 941
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 941
gccgccuacc acggg 15
＜210＞ 942
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 942
acagagucca ccgug 15
＜210＞ 943
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 943
gcuggcuacu aagac 15
＜210＞ 944
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 944
ggcuacuaag acuuu 15
＜210＞ 945
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 945
uaagacuuuc ggcag 15
＜210＞ 946
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 946
aagacuuucg gcagc 15
＜210＞ 947
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 947
agacuuucgg cagcu 15
＜210＞ 948
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 948
uccggaucgu cggcc 15
＜210＞ 949
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 949
ggaucgucgg ccguu 15
＜210＞ 950
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 950
cggccguuga cagcg 15
＜210＞ 951
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 951
ucguacuccu ccaug 15
＜210＞ 952
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 952
uacuccucca ugccc 15
＜210＞ 953
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 953
ccccccuuga ggggg 15
＜210＞ 954
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 954
cccugaucuc agcga 15
＜210＞ 955
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 955
cugaucucag cgacg 15
＜210＞ 956
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 956
gacgggucuu ggucu 15
＜210＞ 957
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 957
cgggucuugg ucuac 15
＜210＞ 958
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 958
ucuuggucua ccgug 15
＜210＞ 959
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 959
uuggucuacc gugag 15
＜210＞ 960
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 960
acgacaucgu cugcu 15
＜210＞ 961
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 961
acaucgucug cugcu 15
＜210＞ 962
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 962
ugcugcucaa ugucc 15
＜210＞ 963
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 963
ucaauguccu acaca 15
＜210＞ 964
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 964
ugcccaucaa cgcgu 15
＜210＞ 965
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 965
acaacauccc gcagu 15
＜210＞ 966
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 966
ugcaaguccu ggacg 15
＜210＞ 967
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 967
gaccacuacc gggac 15
＜210＞ 968
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 968
uaaggcuaaa cuucu 15
＜210＞ 969
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 969
aacuucuauc cguag 15
＜210＞ 970
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 970
cuucuauccg uagaa 15
＜210＞ 971
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 971
uauccguaga agaag 15
＜210＞ 972
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 972
gccaaaucua aauuu 15
＜210＞ 973
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 973
caaaucuaaa uuugg 15
＜210＞ 974
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 974
ucuaaauuug gcuau 15
＜210＞ 975
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 975
cuaaauuugg cuaug 15
＜210＞ 976
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 976
uuuggcuaug gggca 15
＜210＞ 977
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 977
accacauccg cuccg 15
＜210＞ 978
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 978
auccgcuccg ugugg 15
＜210＞ 979
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 979
cucgccuuau cguau 15
＜210＞ 980
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 980
ucgccuuauc guauu 15
＜210＞ 981
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 981
gccuuaucgu auucc 15
＜210＞ 982
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 982
uccucguacg gauuc 15
＜210＞ 983
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 983
uacggauucc aguac 15
＜210＞ 984
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 984
uuccaguacu cuccu 15
＜210＞ 985
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 985
guacucuccu gggca 15
＜210＞ 986
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 986
agcggguuga guucc 15
＜210＞ 987
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 987
guugaguucc uggug 15
＜210＞ 988
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 988
uugaguuccu gguga 15
＜210＞ 989
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 989
uggaaaucaa agaaa 15
＜210＞ 990
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 990
aggccauaaa gucgc 15
＜210＞ 991
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 991
auaaagucgc ucacg 15
＜210＞ 992
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 992
agucgcucac ggagc 15
＜210＞ 993
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 993
agcggcucua caucg 15
＜210＞ 994
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 994
cggcucuaca ucggg 15
＜210＞ 995
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 995
ucuacaucgg gggcc 15
＜210＞ 996
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 996
cugcgguuau cgccg 15
＜210＞ 997
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 997
ugcgguuauc gccgg 15
＜210＞ 998
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 998
cgguuaucgc cggug 15
＜210＞ 999
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 999
gacgacuagc ugcgg 15
＜210＞ 1000
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1000
ggccugucga gcugc 15
＜210＞ 1001
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1001
caaagcucca ggacu 15
＜210＞ 1002
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1002
cgaugcucgu gaacg 15
＜210＞ 1003
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1003
acgaccuugu cguua 15
＜210＞ 1004
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1004
accuugucgu uaucu 15
＜210＞ 1005
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1005
uugucguuau cugug 15
＜210＞ 1006
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1006
agguacucug ccccc 15
＜210＞ 1007
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1007
ccagaauacg acuug 15
＜210＞ 1008
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1008
ucaugcuccu ccaac 15
＜210＞ 1009
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1009
ugcuccucca acgug 15
＜210＞ 1010
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1010
gacgcauccg gcaaa 15
＜210＞ 1011
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1011
ccccccuugc acggg 15
＜210＞ 1012
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1012
aucauguaug cgccc 15
＜210＞ 1013
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1013
cccaccuuau gggca 15
＜210＞ 1014
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1014
ccaccuuaug ggcaa 15
＜210＞ 1015
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1015
gaugauuuug augac 15
＜210＞ 1016
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1016
gaugacucac uucuu 15
＜210＞ 1017
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1017
ccuggauugu cagau 15
＜210＞ 1018
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1018
ggauugucag aucua 15
＜210＞ 1019
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1019
gucagaucua cgggg 15
＜210＞ 1020
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1020
cagaucuacg gggcc 15
＜210＞ 1021
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1021
caugccucag gaaac 15
＜210＞ 1022
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1022
ggaaacuugg gguac 15
＜210＞ 1023
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1023
uugggguacc gcccu 15
＜210＞ 1024
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1024
ccgcccuugc gaguc 15
＜210＞ 1025
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1025
ugcgagucug gagac 15
＜210＞ 1026
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1026
gaaguguccg cgcua 15
＜210＞ 1027
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1027
ccgcgcuagg cuacu 15
＜210＞ 1028
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1028
cuaggcuacu guccc 15
＜210＞ 1029
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1029
cuacuguccc aaggg 15
＜210＞ 1030
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1030
gccgcguccc agcug 15
＜210＞ 1031
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1031
cuggacuugu ccagc 15
＜210＞ 1032
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1032
gacuugucca gcugg 15
＜210＞ 1033
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1033
agcugguucg uugcu 15
＜210＞ 1034
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1034
gcugguucgu ugcug 15
＜210＞ 1035
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1035
gguucguugc ugguu 15
＜210＞ 1036
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1036
gagacauaua ucaca 15
＜210＞ 1037
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1037
gacauauauc acagc 15
＜210＞ 1038
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1038
cauauaucac agccu 15
＜210＞ 1039
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1039
agccugucuc gugcc 15
＜210＞ 1040
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1040
ggugccuacu ccuac 15
＜210＞ 1041
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1041
gccuacuccu acuuu 15
＜210＞ 1042
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1042
uacuccuacu uuccg 15
＜210＞ 1043
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1043
uccuacuuuc cguag 15
＜210＞ 1044
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1044
ccuacuuucc guagg 15
＜210＞ 1045
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1045
cuacuuuccg uaggg 15
＜210＞ 1046
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1046
uuuccguagg gguag 15
＜210＞ 1047
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1047
uagggguagg caucu 15
＜210＞ 1048
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1048
uaggcaucua ccugc 15
＜210＞ 1049
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1049
ggcaucuacc ugcuc 15
＜210＞ 1050
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1050
accugcuccc caacc 15
＜210＞ 1051
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1051
gggagcuaau cacuc 15
＜210＞ 1052
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1052
agcuaaucac uccag 15
＜210＞ 1053
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1053
aaucacucca ggcca 15
＜210＞ 1054
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1054
ggccaauagg ccauc 15
＜210＞ 1055
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1055
cgccccccug augagncgaa aucgggg 27
＜210＞ 1056
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1056
agugauccug augagncgaa auggugg 27
＜210＞ 1057
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1057
ggggagucug augagncgaa aucuaug 27
＜210＞ 1058
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1058
cacagggcug augagncgaa agugauc 27
＜210＞ 1059
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1059
aagacagcug augagncgaa aguuccu 27
＜210＞ 1060
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1060
gcgugaacug augagncgaa acaguag 27
＜210＞ 1061
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1061
cugcgugcug augagncgaa agacagu 27
＜210＞ 1062
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1062
ucugcgucug augagncgaa aagacag 27
＜210＞ 1063
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1063
auggcuacug augagncgaa acgcuuu 27
＜210＞ 1064
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1064
ccauggccug augagncgaa agacgcu 27
＜210＞ 1065
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1065
ucauacucug augagncgaa acgccau 27
＜210＞ 1066
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1066
cucauaccug augagncgaa aacgcca 27
＜210＞ 1067
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1067
acacucacug augagncgaa acuaacg 27
＜210＞ 1068
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1068
gcugcaccug augagncgaa acacuca 27
＜210＞ 1069
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1069
agaccaccug augagncgaa auggcuc 27
＜210＞ 1070
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1070
aagaaagcug augagncgaa acccggu 27
＜210＞ 1071
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1071
uccaagacug augagncgaa aggaccc 27
＜210＞ 1072
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1072
auccaagcug augagncgaa aaggacc 27
＜210＞ 1073
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1073
gauccaacug augagncgaa aaaggac 27
＜210＞ 1074
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1074
gcggguucug augagncgaa auccaag 27
＜210＞ 1075
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1075
acgcccacug augagncgaa aucucca 27
＜210＞ 1076
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1076
cacgccccug augagncgaa aaucucc 27
＜210＞ 1077
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1077
guaccaccug augagncgaa aggccuu 27
＜210＞ 1078
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1078
gguuuagcug augagncgaa auucgug 27
＜210＞ 1079
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1079
ugagguucug augagncgaa aggauuc 27
＜210＞ 1080
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1080
uuucuuucug augagncgaa agguuua 27
＜210＞ 1081
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1081
uaggugucug augagncgaa acguuug 27
＜210＞ 1082
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1082
gcggcggcug augagncgaa agguguu 27
＜210＞ 1083
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1083
caccaaccug augagncgaa aucugac 27
＜210＞ 1084
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1084
cuccacccug augagncgaa acgaucu 27
＜210＞ 1085
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1085
acacguacug augagncgaa acuccac 27
＜210＞ 1086
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1086
aacacgucug augagncgaa aacucca 27
＜210＞ 1087
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1087
caacacgcug augagncgaa aaacucc 27
＜210＞ 1088
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1088
gcgcggccug augagncgaa acacgua 27
＜210＞ 1089
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1089
cuuccaccug augagncgaa agguugc 27
＜210＞ 1090
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1090
auugcgccug augagncgaa accuccg 27
＜210＞ 1091
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1091
augaccucug augagncgaa acccaga 27
＜210＞ 1092
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1092
cgcacgucug augagncgaa aggguau 27
＜210＞ 1093
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1093
accccaucug augagncgaa aggucgg 27
＜210＞ 1094
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1094
auagagacug augagncgaa agagcaa 27
＜210＞ 1095
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1095
gauagagcug augagncgaa aagagca 27
＜210＞ 1096
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1096
agauagacug augagncgaa aaagagc 27
＜210＞ 1097
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1097
gaagauacug augagncgaa agaaaga 27
＜210＞ 1098
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1098
aggaagacug augagncgaa agagaaa 27
＜210＞ 1099
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1099
agaggaacug augagncgaa auagaga 27
＜210＞ 1100
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1100
caagaggcug augagncgaa agauaga 27
＜210＞ 1101
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1101
ccaagagcug augagncgaa aagauag 27
＜210＞ 1102
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1102
gggccaacug augagncgaa aggaaga 27
＜210＞ 1103
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1103
cagggcccug augagncgaa agaggaa 27
＜210＞ 1104
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1104
caaacagcug augagncgaa acagcag 27
＜210＞ 1105
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1105
auggucacug augagncgaa acaggac 27
＜210＞ 1106
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1106
gaugguccug augagncgaa aacagga 27
＜210＞ 1107
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1107
aagcuggcug augagncgaa augguca 27
＜210＞ 1108
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1108
uaagcggcug augagncgaa agcuggg 27
＜210＞ 1109
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1109
auaagcgcug augagncgaa aagcugg 27
＜210＞ 1110
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1110
accugaucug augagncgaa agcggaa 27
＜210＞ 1111
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1111
caccugacug augagncgaa aagcgga 27
＜210＞ 1112
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1112
cgcaccucug augagncgaa auaagcg 27
＜210＞ 1113
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1113
cagcccgcug augagncgaa augcguu 27
＜210＞ 1114
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1114
gacauggcug augagncgaa acagccc 27
＜210＞ 1115
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1115
cauucgucug augagncgaa acauggu 27
＜210＞ 1116
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1116
ugaguugcug augagncgaa agcaguc 27
＜210＞ 1117
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1117
aaugcuucug augagncgaa aguugga 27
＜210＞ 1118
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1118
cauacaccug augagncgaa augcuug 27
＜210＞ 1119
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1119
ccgggggcug augagncgaa augcaug 27
＜210＞ 1120
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1120
ugggagucug augagncgaa agcgcua 27
＜210＞ 1121
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1121
agcguggcug augagncgaa agugagc 27
＜210＞ 1122
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1122
uggccgccug augagncgaa agcgugg 27
＜210＞ 1123
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1123
uagugggcug augagncgaa augcugg 27
＜210＞ 1124
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1124
auugucgcug augagncgaa agugggg 27
＜210＞ 1125
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1125
ggcgucgcug augagncgaa auugucg 27
＜210＞ 1126
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1126
gaacagacug augagncgaa agcggcc 27
＜210＞ 1127
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1127
auccgcacug augagncgaa agguccc 27
＜210＞ 1128
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1128
gggagaccug augagncgaa aggaaaa 27
＜210＞ 1129
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1129
acugggacug augagncgaa acgagga 27
＜210＞ 1130
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1130
caacuggcug augagncgaa agacgag 27
＜210＞ 1131
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1131
ggugaaccug augagncgaa acuggga 27
＜210＞ 1132
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1132
gaaggugcug augagncgaa acaacug 27
＜210＞ 1133
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1133
agaaggucug augagncgaa aacaacu 27
＜210＞ 1134
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1134
aggcgagcug augagncgaa aggugaa 27
＜210＞ 1135
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1135
gaggcgacug augagncgaa aagguga 27
＜210＞ 1136
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1136
gcgaggccug augagncgaa agaaggu 27
＜210＞ 1137
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1137
uaccggccug augagncgaa aggcgag 27
＜210＞ 1138
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1138
ugucucacug augagncgaa accggcg 27
＜210＞ 1139
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1139
aguccugcug augagncgaa acugucu 27
＜210＞ 1140
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1140
auugagccug augagncgaa auugcag 27
＜210＞ 1141
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1141
auagauucug augagncgaa agcaauu 27
＜210＞ 1142
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1142
cgggauacug augagncgaa auugagc 27
＜210＞ 1143
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1143
gccgggacug augagncgaa agauuga 27
＜210＞ 1144
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1144
uggccggcug augagncgaa auagauu 27
＜210＞ 1145
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1145
auauccccug augagncgaa agccaug 27
＜210＞ 1146
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1146
aucaucacug augagncgaa aucccaa 27
＜210＞ 1147
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1147
uguaggccug augagncgaa accaguu 27
＜210＞ 1148
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1148
gcuguugcug augagncgaa aggcgac 27
＜210＞ 1149
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1149
acaccaccug augagncgaa agggcug 27
＜210＞ 1150
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1150
uaacugccug augagncgaa acaccac 27
＜210＞ 1151
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1151
ccggagucug augagncgaa acugcga 27
＜210＞ 1152
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1152
uccggagcug augagncgaa aacugcg 27
＜210＞ 1153
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1153
ggauccgcug augagncgaa aguaacu 27
＜210＞ 1154
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1154
cuuguggcug augagncgaa auccgga 27
＜210＞ 1155
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1155
aagaccucug augagncgaa agcccag 27
＜210＞ 1156
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1156
caaucaacug augagncgaa accuuag 27
＜210＞ 1157
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1157
cacaauccug augagncgaa agaccuu 27
＜210＞ 1158
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1158
acaucaccug augagncgaa aucaaga 27
＜210＞ 1159
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1159
aaagagucug augagncgaa acaucac 27
＜210＞ 1160
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1160
caaagagcug augagncgaa aacauca 27
＜210＞ 1161
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1161
cggcaaacug augagncgaa aguaaca 27
＜210＞ 1162
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1162
gccggcacug augagncgaa agaguaa 27
＜210＞ 1163
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1163
cgccggccug augagncgaa aagagua 27
＜210＞ 1164
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1164
ccccguccug augagncgaa acgccgg 27
＜210＞ 1165
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1165
uguaagucug augagncgaa accccgu 27
＜210＞ 1166
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1166
gucgugucug augagncgaa agugacc 27
＜210＞ 1167
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1167
ugucgugcug augagncgaa aagugac 27
＜210＞ 1168
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1168
agcuugccug augagncgaa acccccc 27
＜210＞ 1169
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1169
guguggccug augagncgaa agcuugc 27
＜210＞ 1170
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1170
aggacgucug augagncgaa acgcucu 27
＜210＞ 1171
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1171
gaagaagcug augagncgaa acgugac 27
＜210＞ 1172
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1172
ggugaagcug augagncgaa aggacgu 27
＜210＞ 1173
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1173
gggugaacug augagncgaa aaggacg 27
＜210＞ 1174
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1174
uugggugcug augagncgaa agaagga 27
＜210＞ 1175
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1175
cuugggucug augagncgaa aagaagg 27
＜210＞ 1176
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1176
ugagcugcug augagncgaa auucucu 27
＜210＞ 1177
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1177
uguuuaucug augagncgaa agcugga 27
＜210＞ 1178
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1178
ugguguucug augagncgaa augagcu 27
＜210＞ 1179
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1179
uccuguucug augagncgaa augugcc 27
＜210＞ 1180
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1180
guugaggcug augagncgaa auucauu 27
＜210＞ 1181
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1181
cgguguucug augagncgaa agggauu 27
＜210＞ 1182
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1182
ggcaaagcug augagncgaa acccggu 27
＜210＞ 1183
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1183
cggcaaacug augagncgaa aacccgg 27
＜210＞ 1184
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1184
ugcggcacug augagncgaa agaaccc 27
＜210＞ 1185
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1185
gugcggccug augagncgaa aagaacc 27
＜210＞ 1186
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1186
ugcguagcug augagncgaa acagugc 27
＜210＞ 1187
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1187
gugcguacug augagncgaa aacagug 27
＜210＞ 1188
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1188
gugugcgcug augagncgaa agaacag 27
＜210＞ 1189
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1189
cgaguugcug augagncgaa acuugug 27
＜210＞ 1190
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1190
acgaguucug augagncgaa aacuugu 27
＜210＞ 1191
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1191
uccggaccug augagncgaa aguugaa 27
＜210＞ 1192
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1192
gcauccgcug augagncgaa acgaguu 27
＜210＞ 1193
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1193
gucgaugcug augagncgaa agcugca 27
＜210＞ 1194
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1194
ggcucggcug augagncgaa auaggug 27
＜210＞ 1195
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1195
agguccccug augagncgaa aggcucg 27
＜210＞ 1196
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1196
ggccucucug augagncgaa auccagg 27
＜210＞ 1197
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1197
cagcagucug augagncgaa aggccuc 27
＜210＞ 1198
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1198
gaaacagcug augagncgaa acacugg 27
＜210＞ 1199
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1199
ggggugacug augagncgaa acaguac 27
＜210＞ 1200
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1200
uggggugcug augagncgaa aacagua 27
＜210＞ 1201 ＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1201
uuggggucug augagncgaa aaacagu 27
＜210＞ 1202
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1202
uguugagcug augagncgaa agcagca 27
＜210＞ 1203
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1203
uuguugacug augagncgaa aagcagc 27
＜210＞ 1204
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1204
uguuguucug augagncgaa agaagca 27
＜210＞ 1205
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1205
cuuggugcug augagncgaa acccagu 27
＜210＞ 1206
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1206
ucuuggucug augagncgaa aacccag 27
＜210＞ 1207
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1207
cgaaagccug augagncgaa auccgug 27
＜210＞ 1208
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1208
cuuccgacug augagncgaa agcaauc 27
＜210＞ 1209
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1209
gcuuccgcug augagncgaa aagcaau 27
＜210＞ 1210
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1210
ugcuucccug augagncgaa aaagcaa 27
＜210＞ 1211
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1211
auacacccug augagncgaa agguguu 27
＜210＞ 1212
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1212
ucaacuacug augagncgaa acaccua 27
＜210＞ 1213
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1213
agucaaccug augagncgaa auacacc 27
＜210＞ 1214
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1214
gguaguccug augagncgaa acuauac 27
＜210＞ 1215
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1215
guaugggcug augagncgaa agucaac 27
＜210＞ 1216
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1216
gagccugcug augagncgaa augggua 27
＜210＞ 1217
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1217
agugccacug augagncgaa agccugu 27
＜210＞ 1218
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1218
gcaggggcug augagncgaa agugcca 27
＜210＞ 1219
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1219
uaaaguucug augagncgaa acagugc 27
＜210＞ 1220
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1220
gaugguacug augagncgaa aguugac 27
＜210＞ 1221
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1221
agauggucug augagncgaa aaguuga 27
＜210＞ 1222
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1222
aagauggcug augagncgaa aaaguug 27
＜210＞ 1223
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1223
uaaccuucug augagncgaa aagaugg 27
＜210＞ 1224
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1224
cuaaccucug augagncgaa aaagaug 27
＜210＞ 1225
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1225
acauccucug augagncgaa accuuaa 27
＜210＞ 1226
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1226
uacaucccug augagncgaa aaccuua 27
＜210＞ 1227
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1227
ccccacacug augagncgaa acauccu 27
＜210＞ 1228
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1228
ucuccuccug augagncgaa aguccag 27
＜210＞ 1229
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1229
aacagggcug augagncgaa agugucu 27
＜210＞ 1230
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1230
gaacaggcug augagncgaa aaguguc 27
＜210＞ 1231
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1231
gugaaggcug augagncgaa acaggga 27
＜210＞ 1232
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1232
ggugaagcug augagncgaa aacaggg 27
＜210＞ 1233
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1233
gguggugcug augagncgaa aggaaca 27
＜210＞ 1234
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1234
ggguggucug augagncgaa aaggaac 27
＜210＞ 1235
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1235
gagccggcug augagncgaa agggugg 27
＜210＞ 1236
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1236
guggacacug augagncgaa agccggu 27
＜210＞ 1237
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1237
accagugcug augagncgaa acagagc 27
＜210＞ 1238
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1238
uggaucacug augagncgaa accagug 27
＜210＞ 1239
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1239
guggauccug augagncgaa aaccagu 27
＜210＞ 1240
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1240
ggaggugcug augagncgaa aucaaac 27
＜210＞ 1241
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1241
guacaggcug augagncgaa acugcac 27
＜210＞ 1242
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1242
uauaccgcug augagncgaa acaggua 27
＜210＞ 1243
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1243
gacccuacug augagncgaa accguac 27
＜210＞ 1244
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1244
cugaccccug augagncgaa auaccgu 27
＜210＞ 1245
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1245
aaccgcucug augagncgaa acccuau 27
＜210＞ 1246
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1246
aggagaccug augagncgaa accgcug 27
＜210＞ 1247
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1247
caaaggacug augagncgaa acaaccg 27
＜210＞ 1248
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1248
cacaaagcug augagncgaa agacaac 27
＜210＞ 1249
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1249
gaucacacug augagncgaa aggagac 27
＜210＞ 1250
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1250
ugaucaccug augagncgaa aaggaga 27
＜210＞ 1251
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1251
cccauuucug augagncgaa aucacaa 27
＜210＞ 1252
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1252
cacgauacug augagncgaa acuccca 27
＜210＞ 1253
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1253
aacacgacug augagncgaa auacucc 27
＜210＞ 1254
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1254
gcaacaccug augagncgaa auauacu 27
＜210＞ 1255
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1255
gaaaagccug augagncgaa acacgau 27
＜210＞ 1256
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1256
gaaggaacug augagncgaa agcaaca 27
＜210＞ 1257
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1257
agaaggacug augagncgaa aagcaac 27
＜210＞ 1258
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1258
gagaaggcug augagncgaa aaagcaa 27
＜210＞ 1259
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1259
ggagaagcug augagncgaa aaaagca 27
＜210＞ 1260
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1260
ccaggagcug augagncgaa aggaaaa 27
＜210＞ 1261
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1261
gccaggacug augagncgaa aaggaaa 27
＜210＞ 1262
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1262
ccgccagcug augagncgaa agaagga 27
＜210＞ 1263
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1263
cauccaccug augagncgaa agcaggc 27
＜210＞ 1264
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1264
ccugggccug augagncgaa aucagca 27
＜210＞ 1265
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1265
ggccaggcug augagncgaa acgccgc 27
＜210＞ 1266
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1266
aggagagcug augagncgaa augccau 27
＜210＞ 1267
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1267
aaggagacug augagncgaa aaugcca 27
＜210＞ 1268
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1268
ggaaggacug augagncgaa agaaugc 27
＜210＞ 1269
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1269
aaggaagcug augagncgaa agagaau 27
＜210＞ 1270
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1270
cacaaggcug augagncgaa aggagag 27
＜210＞ 1271
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1271
acacaagcug augagncgaa aaggaga 27
＜210＞ 1272
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1272
aaaacaccug augagncgaa aggaagg 27
＜210＞ 1273
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1273
acagaaacug augagncgaa acacaag 27
＜210＞ 1274
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1274
cacagaacug augagncgaa aacacaa 27
＜210＞ 1275
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1275
gcacagacug augagncgaa aaacaca 27
＜210＞ 1276
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1276
ggcacagcug augagncgaa aaaacac 27
＜210＞ 1277
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1277
cggcacacug augagncgaa aaaaaca 27
＜210＞ 1278
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1278
ggagcagcug augagncgaa agcagcg 27
＜210＞ 1279
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1279
ugguggucug augagncgaa acgccag 27
＜210＞ 1280
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1280
gugguggcug augagncgaa aacgcca 27
＜210＞ 1281
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1281
uccacaccug augagncgaa augcagc 27
＜210＞ 1282
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1282
cuacaaacug augagncgaa accaccc 27
＜210＞ 1283
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1283
ccuacaacug augagncgaa aaccacc 27
＜210＞ 1284
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1284
accuacacug augagncgaa aaaccac 27
＜210＞ 1285
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1285
gaccuaccug augagncgaa aaaacca 27
＜210＞ 1286
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1286
uuagacccug augagncgaa acaaaaa 27
＜210＞ 1287
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1287
aguauuacug augagncgaa accuaca 27
＜210＞ 1288
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1288
agaguaucug augagncgaa agaccua 27
＜210＞ 1289
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1289
ucaagagcug augagncgaa auuagac 27
＜210＞ 1290
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1290
aggucaacug augagncgaa aguauua 27
＜210＞ 1291
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1291
caagguccug augagncgaa agaguau 27
＜210＞ 1292
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1292
uggugaccug augagncgaa aggucaa 27
＜210＞ 1293
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1293
guguggucug augagncgaa acaaggu 27
＜210＞ 1294
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1294
cacuuugcug augagncgaa agugugg 27
＜210＞ 1295
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1295
ggcgaggcug augagncgaa acacuuu 27
＜210＞ 1296
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1296
uggcgagcug augagncgaa aacacuu 27
＜210＞ 1297
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1297
gccuggccug augagncgaa aggaaca 27
＜210＞ 1298
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1298
accauaucug augagncgaa agccugg 27
＜210＞ 1299
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1299
accaccacug augagncgaa augagcc 27
＜210＞ 1300
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1300
cuggugacug augagncgaa aaaguau 27
＜210＞ 1301
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1301
cccuggucug augagncgaa auaaagu 27
＜210＞ 1302
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1302
caaagaucug augagncgaa agcucug 27
＜210＞ 1303
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1303
ugucaaacug augagncgaa auuagcu 27
＜210＞ 1304
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1304
aaugucacug augagncgaa agauuag 27
＜210＞ 1305
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1305
uaauguccug augagncgaa aagauua 27
＜210＞ 1306
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1306
guuuggucug augagncgaa augucaa 27
＜210＞ 1307
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1307
aguuuggcug augagncgaa aauguca 27
＜210＞ 1308
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1308
cgagcagcug augagncgaa aguuugg 27
＜210＞ 1309
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1309
gaauggccug augagncgaa agcagga 27
＜210＞ 1310
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1310
gaccgagcug augagncgaa auggcga 27
＜210＞ 1311
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1311
ggaccgacug augagncgaa aauggcg 27
＜210＞ 1312
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1312
gcggacccug augagncgaa agaaugg 27
＜210＞ 1313
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1313
augagcgcug augagncgaa accgaga 27
＜210＞ 1314
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1314
gcaccaucug augagncgaa agcggac 27
＜210＞ 1315
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1315
cagccugcug augagncgaa agcacca 27
＜210＞ 1316
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1316
uacaaagcug augagncgaa acggcau 27
＜210＞ 1317
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1317
gcguacacug augagncgaa aguacgg 27
＜210＞ 1318
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1318
cgcguaccug augagncgaa aaguacg 27
＜210＞ 1319
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1319
gagcgcgcug augagncgaa acaaagu 27
＜210＞ 1320
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1320
agccccucug augagncgaa agcgcgu 27
＜210＞ 1321
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1321
cacgaaucug augagncgaa agccccu 27
＜210＞ 1322
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1322
gcacgaacug augagncgaa aagcccc 27
＜210＞ 1323
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1323
augcacgcug augagncgaa auaagcc 27
＜210＞ 1324
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1324
caugcaccug augagncgaa aauaagc 27
＜210＞ 1325
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1325
ccgcacccug augagncgaa acaugca 27
＜210＞ 1326
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1326
cuccggccug augagncgaa acuuucc 27
＜210＞ 1327
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1327
acguacgcug augagncgaa accuguc 27
＜210＞ 1328
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1328
auagacgcug augagncgaa acguacc 27
＜210＞ 1329
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1329
ggucauacug augagncgaa acguacg 27
＜210＞ 1330
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1330
auggucacug augagncgaa agacgua 27
＜210＞ 1331
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1331
gggguaacug augagncgaa augguca 27
＜210＞ 1332
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1332
gcggggucug augagncgaa agauggu 27
＜210＞ 1333
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1333
agcggggcug augagncgaa aagaugg 27
＜210＞ 1334
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1334
cgggcuccug augagncgaa acugcca 27
＜210＞ 1335
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1335
ugucagacug augagncgaa aagacga 27
＜210＞ 1336
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1336
caugucacug augagncgaa agaagac 27
＜210＞ 1337
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1337
gucccagcug augagncgaa aguaucu 27
＜210＞ 1338
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1338
ggucccacug augagncgaa aaguauc 27
＜210＞ 1339
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1339
ucaaugccug augagncgaa aucggcc 27
＜210＞ 1340
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1340
gcccuuccug augagncgaa augcuau 27
＜210＞ 1341
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1341
uugggcgcug augagncgaa aggccgu 27
＜210＞ 1342
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1342
aaccaagcug augagncgaa aggcccc 27
＜210＞ 1343
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1343
ugcaacccug augagncgaa aguaggc 27
＜210＞ 1344
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1344
acaaugccug augagncgaa accaagu 27
＜210＞ 1345
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1345
uaguaaccug augagncgaa augcaac 27
＜210＞ 1346
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1346
ggcuagucug augagncgaa acaaugc 27
＜210＞ 1347
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1347
aggcuagcug augagncgaa aacaaug 27
＜210＞ 1348
＜211＞ 27 ＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1348
gugaggccug augagncgaa aguaaca 27
＜210＞ 1349
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1349
ccccuuccug augagncgaa accuggu 27
＜210＞ 1350
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1350
caggaaacug augagncgaa auugugu 27
＜210＞ 1351
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1351
gccaggacug augagncgaa agauugu 27
＜210＞ 1352
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1352
cgccaggcug augagncgaa aagauug 27
＜210＞ 1353
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1353
ucgccagcug augagncgaa aaagauu 27
＜210＞ 1354
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1354
caccauucug augagncgaa acgcagg 27
＜210＞ 1355
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1355
acaccaucug augagncgaa aacgcag 27
＜210＞ 1356
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1356
cguggaacug augagncgaa acggucc 27
＜210＞ 1357
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1357
gccguggcug augagncgaa agacggu 27
＜210＞ 1358
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1358
cgccgugcug augagncgaa aagacgg 27
＜210＞ 1359
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1359
uuugggucug augagncgaa auugggc 27
＜210＞ 1360
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1360
auuagugcug augagncgaa acauuug 27
＜210＞ 1361
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1361
ucuacaucug augagncgaa aguguac 27
＜210＞ 1362
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1362
cuugguccug augagncgaa acauuag 27
＜210＞ 1363
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1363
agccgaccug augagncgaa aggucuu 27
＜210＞ 1364
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1364
gccagcccug augagncgaa acgaggu 27
＜210＞ 1365
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1365
uccgagccug augagncgaa accgcag 27
＜210＞ 1366
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1366
ccggaaucug augagncgaa acgucag 27
＜210＞ 1367
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1367
aauaggacug augagncgaa acggguc 27
＜210＞ 1368
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1368
caaauagcug augagncgaa agacggg 27
＜210＞ 1369
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1369
cuucaaacug augagncgaa aggagac 27
＜210＞ 1370
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1370
cccuucacug augagncgaa auaggag 27
＜210＞ 1371
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1371
gcccuuccug augagncgaa aauagga 27
＜210＞ 1372
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1372
acccgaacug augagncgaa agcccuu 27
＜210＞ 1373
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1373
ccacccgcug augagncgaa agagccc 27
＜210＞ 1374
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1374
ggguaugcug augagncgaa aguccac 27
＜210＞ 1375
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1375
cggguaucug augagncgaa aagucca 27
＜210＞ 1376
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1376
caacgggcug augagncgaa augaagu 27
＜210＞ 1377
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1377
uagacuccug augagncgaa acgggua 27
＜210＞ 1378
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1378
uuccauacug augagncgaa acucaac 27
＜210＞ 1379
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1379
guuuccacug augagncgaa agacuca 27
＜210＞ 1380
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1380
cgcauagcug augagncgaa aguuucc 27
＜210＞ 1381
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1381
gaccgcacug augagncgaa aguaguu 27
＜210＞ 1382
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1382
gaccgggcug augagncgaa accgcau 27
＜210＞ 1383
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1383
ccgugaacug augagncgaa accgggg 27
＜210＞ 1384
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1384
guccgugcug augagncgaa agaccgg 27
＜210＞ 1385
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1385
uguccgucug augagncgaa aagaccg 27
＜210＞ 1386
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1386
gggagaucug augagncgaa aguuguc 27
＜210＞ 1387
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1387
cgggggacug augagncgaa augaguu 27
＜210＞ 1388
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1388
gccggggcug augagncgaa agaugag 27
＜210＞ 1389
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1389
ucugcggcug augagncgaa acggccg 27
＜210＞ 1390
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1390
cacuuggcug augagncgaa augucug 27
＜210＞ 1391
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1391
ccacuugcug augagncgaa aaugucu 27
＜210＞ 1392
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1392
gcguguacug augagncgaa augggcc 27
＜210＞ 1393
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1393
gagcgugcug augagncgaa agauggg 27
＜210＞ 1394
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1394
ccaguggcug augagncgaa agcgugu 27
＜210＞ 1395
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1395
ggacgagcug augagncgaa accuugu 27
＜210＞ 1396
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1396
ucaggaccug augagncgaa aguaccu 27
＜210＞ 1397
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1397
gguucagcug augagncgaa acgagua 27
＜210＞ 1398
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1398
ggcaacacug augagncgaa auggguu 27
＜210＞ 1399
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1399
aaaaccccug augagncgaa agguggc 27
＜210＞ 1400
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1400
gccccaacug augagncgaa acccaag 27
＜210＞ 1401
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1401
cgccccacug augagncgaa aacccaa 27
＜210＞ 1402
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1402
acgcccccug augagncgaa aaaccca 27
＜210＞ 1403
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1403
agacauacug augagncgaa acgcccc 27
＜210＞ 1404
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1404
uuagacacug augagncgaa auacgcc 27
＜210＞ 1405
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1405
ugccuuacug augagncgaa acauaua 27
＜210＞ 1406
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1406
ugugccucug augagncgaa agacaua 27
＜210＞ 1407
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1407
gggucggcug augagncgaa accaugu 27
＜210＞ 1408
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1408
ccguggucug augagncgaa auggucc 27
＜210＞ 1409
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1409
cccguggcug augagncgaa aaugguc 27
＜210＞ 1410
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1410
aguacgucug augagncgaa auggggg 27
＜210＞ 1411
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1411
gguggagcug augagncgaa acgugau 27
＜210＞ 1412
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1412
auaggugcug augagncgaa aguacgu 27
＜210＞ 1413
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1413
cccccagcug augagncgaa acaucca 27
＜210＞ 1414
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1414
gcccccacug augagncgaa aacaucc 27
＜210＞ 1415
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1415
gauaucacug augagncgaa aggcgcc 27
＜210＞ 1416
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1416
auuaugacug augagncgaa aucauag 27
＜210＞ 1417
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1417
auauuaucug augagncgaa auaucau 27
＜210＞ 1418
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1418
gucaguucug augagncgaa aguggca 27
＜210＞ 1419
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1419
gguaguccug augagncgaa agucagu 27
＜210＞ 1420
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1420
aggauggcug augagncgaa agucgag 27
＜210＞ 1421
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1421
ugcccagcug augagncgaa augguag 27
＜210＞ 1422
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1422
cugugcccug augagncgaa augccca 27
＜210＞ 1423
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1423
ggaggcgcug augagncgaa agcggug 27
＜210＞ 1424
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1424
gaucccgcug augagncgaa aggcgua 27
＜210＞ 1425
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1425
gguaacccug augagncgaa aucccgg 27
＜210＞ 1426
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1426
gcacggucug augagncgaa accgauc 27
＜210＞ 1427
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1427
ggcacggcug augagncgaa aaccgau 27
＜210＞ 1428
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1428
ccuccuccug augagncgaa auauuug 27
＜210＞ 1429
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1429
uuggacacug augagncgaa agccacc 27
＜210＞ 1430
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1430
gccauagcug augagncgaa aggggau 27
＜210＞ 1431
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1431
ugccauacug augagncgaa aagggga 27
＜210＞ 1432
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1432
cuugccacug augagncgaa agaaggg 27
＜210＞ 1433
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1433
aaaaugacug augagncgaa augccuu 27
＜210＞ 1434
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1434
agaaaaucug augagncgaa agaugcc 27
＜210＞ 1435
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1435
ggcagaacug augagncgaa augagau 27
＜210＞ 1436
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1436
uggcagacug augagncgaa aaugaga 27
＜210＞ 1437
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1437
guggcagcug augagncgaa aaaugag 27
＜210＞ 1438
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1438
aguggcacug augagncgaa aaaauga 27
＜210＞ 1439
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1439
uugcggccug augagncgaa agcucau 27
＜210＞ 1440
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1440
gaggccucug augagncgaa acagcuu 27
＜210＞ 1441
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1441
ugauucccug augagncgaa aggccug 27
＜210＞ 1442
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1442
acgucaacug augagncgaa accccgg 27
＜210＞ 1443
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1443
acacguccug augagncgaa agacccc 27
＜210＞ 1444
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1444
uaugacgcug augagncgaa acacguc 27
＜210＞ 1445
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1445
cgauaaccug augagncgaa acaucuc 27
＜210＞ 1446
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1446
ccacgaucug augagncgaa acgacau 27
＜210＞ 1447
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1447
gccacgacug augagncgaa aacgaca 27
＜210＞ 1448
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1448
uugccaccug augagncgaa auaacga 27
＜210＞ 1449
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1449
gucauuacug augagncgaa agcgucu 27
＜210＞ 1450
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1450
ccgucaucug augagncgaa agagcgu 27
＜210＞ 1451
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1451
cgagucacug augagncgaa agucacc 27
＜210＞ 1452
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1452
ccgaguccug augagncgaa aagucac 27
＜210＞ 1453
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1453
gaucacccug augagncgaa agucaaa 27
＜210＞ 1454
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1454
ucugggucug augagncgaa acacaug 27
＜210＞ 1455
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1455
ugaaauccug augagncgaa acugucu 27
＜210＞ 1456
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1456
aagcugacug augagncgaa aucgacu 27
＜210＞ 1457
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1457
caagcugcug augagncgaa aaucgac 27
＜210＞ 1458
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1458
ccaagcucug augagncgaa aaaucga 27
＜210＞ 1459
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1459
gggaucccug augagncgaa agcugaa 27
＜210＞ 1460
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1460
aagguggcug augagncgaa auccaag 27
＜210＞ 1461
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1461
aaugguacug augagncgaa agguggg 27
＜210＞ 1462
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1462
caauggucug augagncgaa aaggugg 27
＜210＞ 1463
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1463
ucaauggcug augagncgaa aaaggug 27
＜210＞ 1464
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1464
ucgucuccug augagncgaa augguaa 27
＜210＞ 1465
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1465
ccucccccug augagncgaa accccug 27
＜210＞ 1466
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1466
accuguacug augagncgaa augccuc 27
＜210＞ 1467
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1467
aaaccugcug augagncgaa agaugcc 27
＜210＞ 1468
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1468
agucacacug augagncgaa accugua 27
＜210＞ 1469
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1469
gagucaccug augagncgaa aaccugu 27
＜210＞ 1470
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1470
ucucccgcug augagncgaa agucaca 27
＜210＞ 1471
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1471
caugccccug augagncgaa agggccg 27
＜210＞ 1472
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1472
agaaucgcug augagncgaa acaugcc 27
＜210＞ 1473
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1473
aagaauccug augagncgaa aacaugc 27
＜210＞ 1474
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1474
accgaagcug augagncgaa aucgaac 27
＜210＞ 1475
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1475
gaccgaacug augagncgaa aaucgaa 27
＜210＞ 1476
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1476
aggaccgcug augagncgaa agaaucg 27
＜210＞ 1477
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1477
caggacccug augagncgaa aagaauc 27
＜210＞ 1478
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1478
cacacagcug augagncgaa accgaag 27
＜210＞ 1479
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1479
cgcgucacug augagncgaa agcacuc 27
＜210＞ 1480
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1480
uucccagcug augagncgaa acuccag 27
＜210＞ 1481
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1481
uuucccacug augagncgaa aacucca 27
＜210＞ 1482
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1482
cugugaacug augagncgaa acgcuuu 27
＜210＞ 1483
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1483
gccugugcug augagncgaa agacgcu 27
＜210＞ 1484
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1484
ggccugucug augagncgaa aagacgc 27
＜210＞ 1485
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1485
ugugggucug augagncgaa aggccug 27
＜210＞ 1486
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1486
gggcauccug augagncgaa auguggg 27
＜210＞ 1487
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1487
ggacaggcug augagncgaa agugggc 27
＜210＞ 1488
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1488
gggacagcug augagncgaa aaguggg 27
＜210＞ 1489
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1489
gguuuggcug augagncgaa acaggaa 27
＜210＞ 1490
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1490
guaagggcug augagncgaa aguuguc 27
＜210＞ 1491
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1491
gguaaggcug augagncgaa aaguugu 27
＜210＞ 1492
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1492
accaggucug augagncgaa agggaag 27
＜210＞ 1493
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1493
uaccaggcug augagncgaa aagggaa 27
＜210＞ 1494
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1494
ggaggugcug augagncgaa agccuga 27
＜210＞ 1495
＜211＞ 27
＜212＞ RNA ＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1495
cacgaugcug augagncgaa aggugga 27
＜210＞ 1496
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1496
aucccaccug augagncgaa auggagg 27
＜210＞ 1497
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1497
cacauuucug augagncgaa aucccac 27
＜210＞ 1498
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1498
cguaugacug augagncgaa acacuuc 27
＜210＞ 1499
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1499
gccguaucug augagncgaa agacacu 27
＜210＞ 1500
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1500
uaagccgcug augagncgaa augagac 27
＜210＞ 1501
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1501
uagguuucug augagncgaa agccgua 27
＜210＞ 1502
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1502
guagguucug augagncgaa aagccgu 27
＜210＞ 1503
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1503
ugcagcgcug augagncgaa agguuua 27
＜210＞ 1504
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1504
cggcucccug augagncgaa agccuau 27
＜210＞ 1505
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1505
cauuuugcug augagncgaa acggcuc 27
＜210＞ 1506
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1506
ucauuuucug augagncgaa aacggcu 27
＜210＞ 1507
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1507
ugagggucug augagncgaa aucucau 27
＜210＞ 1508
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1508
gaugugucug augagncgaa aggguga 27
＜210＞ 1509
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1509
guuauggcug augagncgaa augugug 27
＜210＞ 1510
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1510
auuuggucug augagncgaa augggau 27
＜210＞ 1511
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1511
caugaugcug augagncgaa auuuggu 27
＜210＞ 1512
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1512
ccaugaucug augagncgaa aauuugg 27
＜210＞ 1513
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1513
augccaucug augagncgaa augaauu 27
＜210＞ 1514
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1514
gucggcccug augagncgaa acaugca 27
＜210＞ 1515
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1515
gcggccacug augagncgaa agcugca 27
＜210＞ 1516
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1516
ccacaaucug augagncgaa accacac 27
＜210＞ 1517
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1517
uacccaccug augagncgaa augacca 27
＜210＞ 1518
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1518
augaucccug augagncgaa acccaca 27
＜210＞ 1519
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1519
cggacaacug augagncgaa augaucc 27
＜210＞ 1520
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1520
ccggacacug augagncgaa aaugauc 27
＜210＞ 1521
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1521
cccggaccug augagncgaa aaaugau 27
＜210＞ 1522
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1522
ccucccgcug augagncgaa acaaaau 27
＜210＞ 1523
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1523
gguagagcug augagncgaa acuuccc 27
＜210＞ 1524
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1524
cccgguacug augagncgaa aggacuu 27
＜210＞ 1525
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1525
cucccggcug augagncgaa agaggac 27
＜210＞ 1526
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1526
uucaucgcug augagncgaa acucccg 27
＜210＞ 1527
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1527
uuucauccug augagncgaa aacuccc 27
＜210＞ 1528
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1528
gaggugucug augagncgaa aggcgca 27
＜210＞ 1529
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1529
uguaaggcug augagncgaa aggugug 27
＜210＞ 1530
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1530
ucgaugucug augagncgaa agggagg 27
＜210＞ 1531
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1531
uucgaugcug augagncgaa aagggag 27
＜210＞ 1532
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1532
ccuguuccug augagncgaa auguaag 27
＜210＞ 1533
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1533
gcucggccug augagncgaa agcugca 27
＜210＞ 1534
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1534
gcaaccccug augagncgaa agugccu 27
＜210＞ 1535
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1535
uugcagccug augagncgaa acccgag 27
＜210＞ 1536
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1536
gcugaugcug augagncgaa aguucca 27
＜210＞ 1537
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1537
cgcugaucug augagncgaa aaguucc 27
＜210＞ 1538
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1538
ucccgcucug augagncgaa augaagu 27
＜210＞ 1539
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1539
aauacugcug augagncgaa aucccgc 27
＜210＞ 1540
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1540
ugcuaaacug augagncgaa acuguau 27
＜210＞ 1541
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1541
ccugcuacug augagncgaa auacugu 27
＜210＞ 1542
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1542
gccugcucug augagncgaa aauacug 27
＜210＞ 1543
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1543
agccugccug augagncgaa aaauacu 27
＜210＞ 1544
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1544
cagagugcug augagncgaa auaagcc 27
＜210＞ 1545
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1545
ccaggcacug augagncgaa aguggau 27
＜210＞ 1546
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1546
gugaugccug augagncgaa aucgcgg 27
＜210＞ 1547
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1547
caucagucug augagncgaa augcuau 27
＜210＞ 1548
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1548
ggcugugcug augagncgaa augccau 27
＜210＞ 1549
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1549
aggcugucug augagncgaa aaugcca 27
＜210＞ 1550
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1550
ggugauacug augagncgaa aggcugu 27
＜210＞ 1551
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1551
cuggugacug augagncgaa agaggcu 27
＜210＞ 1552
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1552
gacuggucug augagncgaa auagagg 27
＜210＞ 1553
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1553
gugagcgcug augagncgaa acuggug 27
＜210＞ 1554
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1554
ggguggucug augagncgaa agcggac 27
＜210＞ 1555
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1555
aggagggcug augagncgaa auucugg 27
＜210＞ 1556
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1556
ugaacagcug augagncgaa aggguau 27
＜210＞ 1557
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1557
ccccuaacug augagncgaa auguuga 27
＜210＞ 1558
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1558
ucccccucug augagncgaa agauguu 27
＜210＞ 1559
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1559
auccccccug augagncgaa aagaugu 27
＜210＞ 1560
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1560
gcgaguucug augagncgaa agcagcc 27
＜210＞ 1561
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1561
gcacuggcug augagncgaa aggagcg 27
＜210＞ 1562
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1562
aaggccgcug augagncgaa agcagca 27
＜210＞ 1563
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1563
uguccaccug augagncgaa agcaccu 27
＜210＞ 1564
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1564
ccgccagcug augagncgaa augucca 27
＜210＞ 1565
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1565
cccgccacug augagncgaa aaugucc 27
＜210＞ 1566
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1566
agggagccug augagncgaa aguuaac 27
＜210＞ 1567
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1567
gggagagcug augagncgaa auggcag 27
＜210＞ 1568
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1568
cgggggacug augagncgaa aggaugg 27
＜210＞ 1569
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1569
cgaacgccug augagncgaa aucagcc 27
＜210＞ 1570
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1570
accccgccug augagncgaa aagcgaa 27
＜210＞ 1571
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1571
acguggucug augagncgaa accccgc 27
＜210＞ 1572
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1572
ugggggacug augagncgaa acguggu 27
＜210＞ 1573
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1573
gugggggcug augagncgaa aacgugg 27
＜210＞ 1574
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1574
cguggggcug augagncgaa aaacgug 27
＜210＞ 1575
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1575
aggcacgcug augagncgaa agugcgu 27
＜210＞ 1576
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1576
ucugagucug augagncgaa acacgug 27
＜210＞ 1577
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1577
aggaucucug augagncgaa aguuaca 27
＜210＞ 1578
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1578
uggagagcug augagncgaa aucugag 27
＜210＞ 1579
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1579
ggcuggacug augagncgaa aggaucu 27
＜210＞ 1580
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1580
gaggcugcug augagncgaa agaggau 27
＜210＞ 1581
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1581
ugauggucug augagncgaa aggcugg 27
＜210＞ 1582
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1582
gcugagucug augagncgaa augguga 27
＜210＞ 1583
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1583
agcagcucug augagncgaa agugaug 27
＜210＞ 1584
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1584
acuggugcug augagncgaa agccucu 27
＜210＞ 1585
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1585
cacuggucug augagncgaa aagccuc 27
＜210＞ 1586
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1586
ccucauucug augagncgaa auccacu 27
＜210＞ 1587
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1587
uccucaucug augagncgaa aauccac 27
＜210＞ 1588
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1588
uggcgugcug augagncgaa agcaguc 27
＜210＞ 1589
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1589
cgagccgcug augagncgaa agcaugg 27
＜210＞ 1590
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1590
uagccaccug augagncgaa agccgga 27
＜210＞ 1591
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1591
cauccuucug augagncgaa agccacg 27
＜210＞ 1592
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1592
agucccacug augagncgaa acauccu 27
＜210＞ 1593
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1593
caguccccug augagncgaa aacaucc 27
＜210＞ 1594
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1594
ccgugcacug augagncgaa auccagu 27
＜210＞ 1595
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1595
gucaguccug augagncgaa acaccgu 27
＜210＞ 1596
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1596
ggucuugcug augagncgaa agucagu 27
＜210＞ 1597
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1597
aggucuucug augagncgaa aagucag 27
＜210＞ 1598
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1598
uggacugcug augagncgaa agccagg 27
＜210＞ 1599
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1599
gagcuugcug augagncgaa acuggag 27
＜210＞ 1600
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1600
ucggcagcug augagncgaa agcuugg 27
＜210＞ 1601
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1601
ucccggccug augagncgaa auuucgg 27
＜210＞ 1602
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1602
agaaaggcug augagncgaa acucccg 27
＜210＞ 1603
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1603
gagaagacug augagncgaa agggacu 27
＜210＞ 1604
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1604
ugagaagcug augagncgaa aagggac 27
＜210＞ 1605
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1605
augagaacug augagncgaa aaaggga 27
＜210＞ 1606
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1606
gcaugagcug augagncgaa agaaagg 27
＜210＞ 1607
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1607
ggcaugacug augagncgaa aagaaag 27
＜210＞ 1608
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1608
uuggcaucug augagncgaa agaagaa 27
＜210＞ 1609
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1609
ucccuugcug augagncgaa acccgcg 27
＜210＞ 1610
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1610
cccgccacug augagncgaa acucccu 27
＜210＞ 1611
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1611
guccggucug augagncgaa auuugug 27
＜210＞ 1612
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1612
uguccggcug augagncgaa aauuugu 27
＜210＞ 1613
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1613
cguuuuucug augagncgaa acauguc 27
＜210＞ 1614
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1614
cucauggcug augagncgaa accguuu 27
＜210＞ 1615
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1615
ccucaugcug augagncgaa aaccguu 27
＜210＞ 1616
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1616
gcccaaccug augagncgaa auccuca 27
＜210＞ 1617
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1617
uaggccccug augagncgaa acgaucc 27
＜210＞ 1618
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1618
cagguuucug augagncgaa aggccca 27
＜210＞ 1619
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1619
gauggggcug augagncgaa acguucc 27
＜210＞ 1620
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1620
ugaugggcug augagncgaa aacguuc 27
＜210＞ 1621
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1621
acgcguucug augagncgaa augggga 27
＜210＞ 1622
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1622
uguggugcug augagncgaa acgcguu 27
＜210＞ 1623
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1623
cgccgggcug augagncgaa agggugu 27
＜210＞ 1624
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1624
cuccacgcug augagncgaa acucuuc 27
＜210＞ 1625
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1625
cccgcgucug augagncgaa aucucca 27
＜210＞ 1626
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1626
acccgcgcug augagncgaa aaucucc 27
＜210＞ 1627
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1627
guggucacug augagncgaa acccguc 27
＜210＞ 1628
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1628
gggccggcug augagncgaa accuggc 27
＜210＞ 1629
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1629
gaccuggcug augagncgaa augugac 27
＜210＞ 1630
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1630
uggaagucug augagncgaa agcacug 27
＜210＞ 1631
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1631
agcauggcug augagncgaa agugagc 27
＜210＞ 1632
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1632
gagcaugcug augagncgaa aagugag 27
＜210＞ 1633
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1633
ggucggucug augagncgaa agcaugg 27
＜210＞ 1634
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1634
aauguggcug augagncgaa agggguc 27
＜210＞ 1635
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1635
cugcugucug augagncgaa auguggg 27
＜210＞ 1636
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1636
ucugcugcug augagncgaa aaugugg 27
＜210＞ 1637
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1637
cuacguucug augagncgaa agccguc 27
＜210＞ 1638
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1638
cuagcugcug augagncgaa agagcug 27
＜210＞ 1639
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1639
gcuagcucug augagncgaa aagagcu 27
＜210＞ 1640
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1640
aauuggccug augagncgaa agcugaa 27
＜210＞ 1641
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1641
uucaaggcug augagncgaa aggcgca 27
＜210＞ 1642
＜211＞ 27
＜212＞ RNA
＜213＞ ArtificialSequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1642
cuucaagcug augagncgaa aaggcgc 27
＜210＞ 1643
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1643
ugccuuccug augagncgaa aggaagg 27
＜210＞ 1644
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1644
uggugggcug augagncgaa agugcau 27
＜210＞ 1645
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1645
guccgggcug augagncgaa agucaug 27
＜210＞ 1646
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1646
ccucgaucug augagncgaa aggucag 27
＜210＞ 1647
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1647
uggccuccug augagncgaa augaggu 27
＜210＞ 1648
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1648
cacgggucug augagncgaa auguuuc 27
＜210＞ 1649
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1649
auucucucug augagncgaa acuccac 27
＜210＞ 1650
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1650
accaccucug augagncgaa auucucu 27
＜210＞ 1651
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1651
ccaaaaucug augagncgaa accaccu 27
＜210＞ 1652
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1652
aguccaacug augagncgaa auuacca 27
＜210＞ 1653
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1653
gaguccacug augagncgaa aauuacc 27
＜210＞ 1654
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1654
agagucccug augagncgaa aaauuac 27
＜210＞ 1655
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1655
gucgaaacug augagncgaa aguccaa 27
＜210＞ 1656
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1656
gggucgacug augagncgaa agagucc 27
＜210＞ 1657
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1657
cgggucgcug augagncgaa aagaguc 27
＜210＞ 1658
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1658
gcggguccug augagncgaa aaagagu 27
＜210＞ 1659
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1659
ugcaacgcug augagncgaa auacuuc 27
＜210＞ 1660
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1660
cugcugccug augagncgaa acggaua 27
＜210＞ 1661
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1661
uucgcagcug augagncgaa aucucug 27
＜210＞ 1662
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1662
cuucuugcug augagncgaa auuuucg 27
＜210＞ 1663
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1663
gggggggcug augagncgaa acuucuu 27
＜210＞ 1664
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1664
cggggggcug augagncgaa aacuucu 27
＜210＞ 1665
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1665
aacagugcug augagncgaa aggguug 27
＜210＞ 1666
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1666
uuuccagcug augagncgaa acucuaa 27
＜210＞ 1667
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1667
gguauugcug augagncgaa agggccc 27
＜210＞ 1668
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1668
gaggcggcug augagncgaa auuggag 27
＜210＞ 1669
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1669
uuccgugcug augagncgaa aggcggu 27
＜210＞ 1670
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1670
ucagaaccug augagncgaa accgucc 27
＜210＞ 1671
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1671
cugucagcug augagncgaa acaaccg 27
＜210＞ 1672
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1672
ucugucacug augagncgaa aacaacc 27
＜210＞ 1673
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1673
ggcagaacug augagncgaa acacggu 27
＜210＞ 1674
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1674
aaggcagcug augagncgaa agacacg 27
＜210＞ 1675
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1675
caaggcacug augagncgaa aagacac 27
＜210＞ 1676
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1676
cuccgcccug augagncgaa aggcaga 27
＜210＞ 1677
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1677
cgauccgcug augagncgaa agcugcc 27
＜210＞ 1678
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1678
ugaucggcug augagncgaa aggggcg 27
＜210＞ 1679
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1679
gaggucucug augagncgaa aucggga 27
＜210＞ 1680
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1680
gucgucacug augagncgaa aggucug 27
＜210＞ 1681
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1681
aacgucacug augagncgaa auucuuu 27
＜210＞ 1682
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1682
acgacuccug augagncgaa acgucag 27
＜210＞ 1683
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1683
ggaguaccug augagncgaa acucaac 27
＜210＞ 1684
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1684
ggaggagcug augagncgaa acgacuc 27
＜210＞ 1685
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1685
ccaugugcug augagncgaa aggacau 27
＜210＞ 1686
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1686
auggcgucug augagncgaa aucaggg 27
＜210＞ 1687
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1687
guugcuccug augagncgaa acgcguu 27
＜210＞ 1688
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1688
cagcagacug augagncgaa aguugcu 27
＜210＞ 1689
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1689
cgcagcacug augagncgaa agaguug 27
＜210＞ 1690
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1690
uuguggucug augagncgaa acgcagc 27
＜210＞ 1691
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1691
uggcauacug augagncgaa accaugu 27
＜210＞ 1692
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1692
uguggcacug augagncgaa agaccau 27
＜210＞ 1693
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1693
caaaggucug augagncgaa accuucu 27
＜210＞ 1694
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1694
ucugucacug augagncgaa aggugac 27
＜210＞ 1695
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1695
gucuguccug augagncgaa aagguga 27
＜210＞ 1696
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1696
ucuccuucug augagncgaa agcacgu 27
＜210＞ 1697
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1697
aacugugcug augagncgaa acgccuu 27
＜210＞ 1698
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1698
uagccuucug augagncgaa acugugg 27
＜210＞ 1699
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1699
uuagccucug augagncgaa aacugug 27
＜210＞ 1700
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1700
cggauagcug augagncgaa aguuuag 27
＜210＞ 1701
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1701
acggauacug augagncgaa aaguuua 27
＜210＞ 1702
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1702
uuggccgcug augagncgaa auguggg 27
＜210＞ 1703
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1703
uuuggcccug augagncgaa aaugugg 27
＜210＞ 1704
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1704
gguuccgcug augagncgaa acguccu 27
＜210＞ 1705
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1705
ugcuggacug augagncgaa agguucc 27
＜210＞ 1706
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1706
cuugcugcug augagncgaa auagguu 27
＜210＞ 1707
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1707
ugugguucug augagncgaa auggccu 27
＜210＞ 1708
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1708
auguggucug augagncgaa aauggcc 27
＜210＞ 1709
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1709
ugguguccug augagncgaa auuggug 27
＜210＞ 1710
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1710
uugccaucug augagncgaa auggugg 27
＜210＞ 1711
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1711
cgcagaacug augagncgaa acuucac 27
＜210＞ 1712
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1712
acgcagacug augagncgaa aacuuca 27
＜210＞ 1713
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1713
gacgcagcug augagncgaa aaacuuc 27
＜210＞ 1714
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1714
ggacgcacug augagncgaa aaaacuu 27
＜210＞ 1715
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1715
ccgguugcug augagncgaa acgcaga 27
＜210＞ 1716
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1716
auaaggccug augagncgaa agcuggc 27
＜210＞ 1717
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1717
cugggaacug augagncgaa acgauaa 27
＜210＞ 1718
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1718
gucugggcug augagncgaa auacgau 27
＜210＞ 1719
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1719
ggucuggcug augagncgaa aauacga 27
＜210＞ 1720
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1720
auacacgcug augagncgaa acuccca 27
＜210＞ 1721
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1721
cauacaccug augagncgaa aacuccc 27
＜210＞ 1722
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1722
ucucgcacug augagncgaa acacgaa 27
＜210＞ 1723
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1723
ucguaaacug augagncgaa agccauu 27
＜210＞ 1724
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1724
cgucguacug augagncgaa agagcca 27
＜210＞ 1725
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1725
acgucgucug augagncgaa aagagcc 27
＜210＞ 1726
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1726
cacgucgcug augagncgaa aaagagc 27
＜210＞ 1727
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1727
ggguggacug augagncgaa accacgu 27
＜210＞ 1728
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1728
aagggugcug augagncgaa agaccac 27
＜210＞ 1729
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1729
ccugaggcug augagncgaa agggugg 27
＜210＞ 1730
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1730
gccugagcug augagncgaa aagggug 27
＜210＞ 1731
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1731
acggccucug augagncgaa aggaagg 27
＜210＞ 1732
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1732
guacgagcug augagncgaa agcccau 27
＜210＞ 1733
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1733
uccguaccug augagncgaa aggagcc 27
＜210＞ 1734
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1734
aguacugcug augagncgaa aauccgu 27
＜210＞ 1735
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1735
cccaggacug augagncgaa aguacug 27
＜210＞ 1736
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1736
aagcccacug augagncgaa agggcuu 27
＜210＞ 1737
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1737
auacgagcug augagncgaa agcccau 27
＜210＞ 1738
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1738
cauacgacug augagncgaa aagccca 27
＜210＞ 1739
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1739
gucauaccug augagncgaa agaagcc 27
＜210＞ 1740
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1740
ggugucacug augagncgaa acgagaa 27
＜210＞ 1741
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1741
ugagucacug augagncgaa agcagcg 27
＜210＞ 1742
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1742
uugaguccug augagncgaa aagcagc 27
＜210＞ 1743
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1743
gacuguucug augagncgaa agucaaa 27
＜210＞ 1744
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1744
ucucagucug augagncgaa acuguug 27
＜210＞ 1745
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1745
caacacgcug augagncgaa augucgc 27
＜210＞ 1746
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1746
acuccuccug augagncgaa acacgga 27
＜210＞ 1747
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1747
guagauucug augagncgaa acuccuc 27
＜210＞ 1748
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1748
auugguacug augagncgaa auugacu 27
＜210＞ 1749
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1749
acauuggcug augagncgaa agauuga 27
＜210＞ 1750
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1750
aagucaccug augagncgaa acauugg 27
＜210＞ 1751
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1751
gggggcccug augagncgaa agucaca 27
＜210＞ 1752
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1752
uuugaaucug augagncgaa agucagg 27
＜210＞ 1753
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1753
ccuuuugcug augagncgaa auuaguc 27
＜210＞ 1754
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1754
cccuuuucug augagncgaa aauuagu 27
＜210＞ 1755
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1755
gugagggcug augagncgaa auugccg 27
＜210＞ 1756
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1756
agcaugucug augagncgaa aggguau 27
＜210＞ 1757
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1757
uuucaagcug augagncgaa agcaugu 27
＜210＞ 1758
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1758
ggcuuuccug augagncgaa aguagca 27
＜210＞ 1759
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1759
ucacagacug augagncgaa aacgaca 27
＜210＞ 1760
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1760
uuucacacug augagncgaa auaacga 27
＜210＞ 1761
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1761
agacucgcug augagncgaa aggcucg 27
＜210＞ 1762
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1762
ccgugaacug augagncgaa acucgua 27
＜210＞ 1763
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1763
cuccgugcug augagncgaa agacucg 27
＜210＞ 1764
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1764
ccuccgucug augagncgaa aagacuc 27
＜210＞ 1765
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1765
cuagucacug augagncgaa agccucc 27
＜210＞ 1766
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1766
gaguacccug augagncgaa agucaua 27
＜210＞ 1767
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1767
ggcagagcug augagncgaa accuagu 27
＜210＞ 1768
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1768
caacucccug augagncgaa agucgua 27
＜210＞ 1769
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1769
uguuauccug augagncgaa acuccaa 27
＜210＞ 1770
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1770
augaugucug augagncgaa aucaacu 27
＜210＞ 1771
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1771
ggagcaucug augagncgaa auguuau 27
＜210＞ 1772
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1772
cgcgacccug augagncgaa acacguu 27
＜210＞ 1773
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1773
cgugcgccug augagncgaa accgaca 27
＜210＞ 1774
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1774
gagguagcug augagncgaa acacucu 27
＜210＞ 1775
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1775
agugaggcug augagncgaa aguacac 27
＜210＞ 1776
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1776
cacgagucug augagncgaa agguagu 27
＜210＞ 1777
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1777
ggaucaccug augagncgaa agugagg 27
＜210＞ 1778
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1778
gugguggcug augagncgaa aucacga 27
＜210＞ 1779
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1779
guguguccug augagncgaa agcuguc 27
＜210＞ 1780
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1780
uugacugcug augagncgaa agugugu 27
＜210＞ 1781
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1781
aggaguucug augagncgaa acuggag 27
＜210＞ 1782
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1782
uagccagcug augagncgaa aguugac 27
＜210＞ 1783
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1783
uguugcccug augagncgaa agccagg 27
＜210＞ 1784
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1784
acaugaucug augagncgaa auguugc 27
＜210＞ 1785
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1785
cauacaucug augagncgaa augaugu 27
＜210＞ 1786
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1786
ucaucaacug augagncgaa aucaucc 27
＜210＞ 1787
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1787
agucauccug augagncgaa aaaucau 27
＜210＞ 1788
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1788
ggagaagcug augagncgaa agugagu 27
＜210＞ 1789
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1789
uggagaacug augagncgaa aagugag 27
＜210＞ 1790
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1790
gauggagcug augagncgaa agaagug 27
＜210＞ 1791
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1791
ggauggacug augagncgaa aagaagu 27
＜210＞ 1792
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1792
aaggaugcug augagncgaa agaagaa 27
＜210＞ 1793
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1793
cuagaagcug augagncgaa auggaga 27
＜210＞ 1794
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1794
gggcuagcug augagncgaa aggaugg 27
＜210＞ 1795
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1795
ugggcuacug augagncgaa aaggaug 27
＜210＞ 1796
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1796
ccugggccug augagncgaa agaagga 27
＜210＞ 1797
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1797
ccuuuuccug augagncgaa agcuguu 27
＜210＞ 1798
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1798
auggagucug augagncgaa acaggcc 27
＜210＞ 1799
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1799
aauggagcug augagncgaa aacaggc 27
＜210＞ 1800
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1800
cucaaugcug augagncgaa aguaaca 27
＜210＞ 1801
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1801
guggcuccug augagncgaa auggagu 27
＜210＞ 1802
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1802
guagguccug augagncgaa aguggcu 27
＜210＞ 1803
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1803
ucugaggcug augagncgaa aggucaa 27
＜210＞ 1804
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1804
augaucucug augagncgaa agguagg 27
＜210＞ 1805
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1805
guugaaucug augagncgaa aucugag 27
＜210＞ 1806
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1806
gucguugcug augagncgaa augaucu 27
＜210＞ 1807
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1807
agucguucug augagncgaa aaugauc 27
＜210＞ 1808
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1808
gaccaugcug augagncgaa agucguu 27
＜210＞ 1809
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1809
gcgcuaacug augagncgaa accaugg 27
＜210＞ 1810
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1810
augcgcucug augagncgaa agaccau 27
＜210＞ 1811
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1811
aaugcgccug augagncgaa aagacca 27
＜210＞ 1812
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1812
gagugagcug augagncgaa augcgcu 27
＜210＞ 1813
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1813
ggagugacug augagncgaa aaugcgc 27
＜210＞ 1814
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1814
auggagucug augagncgaa agaaugc 27
＜210＞ 1815
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1815
aacuaugcug augagncgaa agugaga 27
＜210＞ 1816
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1816
gaguaaccug augagncgaa auggagu 27
＜210＞ 1817
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1817
ggagagucug augagncgaa acuaugg 27
＜210＞ 1818
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1818
uggagagcug augagncgaa aacuaug 27
＜210＞ 1819
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1819
accuggacug augagncgaa aguaacu 27
＜210＞ 1820
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1820
ucaccugcug augagncgaa agaguaa 27
＜210＞ 1821
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1821
cccuauucug augagncgaa aucucac 27
＜210＞ 1822
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1822
gccaccccug augagncgaa auugauc 27
＜210＞ 1823
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1823
aggcaugcug augagncgaa agccacc 27
＜210＞ 1824
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1824
gaggcaucug augagncgaa aagccac 27
＜210＞ 1825
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1825
cuggccccug augagncgaa augucuc 27
＜210＞ 1826
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1826
gaagaggcug augagncgaa acuugcc 27
＜210＞ 1827
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1827
aguugaacug augagncgaa agguacu 27
＜210＞ 1828
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1828
ccaguugcug augagncgaa agaggua 27
＜210＞ 1829
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1829
cccaguucug augagncgaa aagaggu 27
＜210＞ 1830
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1830
ugguccucug augagncgaa acugccc 27
＜210＞ 1831
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1831
ugaguuucug augagncgaa agcuugg 27
＜210＞ 1832
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1832
uuggagucug augagncgaa aguuuga 27
＜210＞ 1833
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1833
gggauugcug augagncgaa agugagu 27
＜210＞ 1834
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1834
cggccggcug augagncgaa auuggag 27
＜210＞ 1835
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1835
ccgcugucug augagncgaa accagca 27
＜210＞ 1836
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1836
cccgcugcug augagncgaa aaccagc 27
＜210＞ 1837
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1837
cgggcaccug augagncgaa agacagg 27
＜210＞ 1838
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1838
ccacauacug augagncgaa accagcg 27
＜210＞ 1839
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1839
accacaucug augagncgaa aaccagc 27
＜210＞ 1840
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1840
caccacacug augagncgaa aaaccag 27
＜210＞ 1841
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1841
aaaagggcug augagncgaa auggccu 27
＜210＞ 1842
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 1842
aaaaaaacug augagncgaa aggggau 27
＜210＞ 1843
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1843
ccccgauugg gggcg 15
＜210＞ 1844
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1844
ccaccauaga ucacu 15
＜210＞ 1845
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1845
cauagaucac ucccc 15
＜210＞ 1846
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1846
gaucacuccc cugug 15
＜210＞ 1847
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1847
aggaacuacu gucuu 15
＜210＞ 1848
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1848
cuacugucuu cacgc 15
＜210＞ 1849
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1849
acugucuuca cgcag 15
＜210＞ 1850
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1850
cugucuucac gcaga 15
＜210＞ 1851
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1851
aaagcgucua gccau 15
＜210＞ 1852
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1852
agcgucuagc caugg 15
＜210＞ 1853
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1853
auggcguuag uauga 15
＜210＞ 1854
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1854
uggcguuagu augag 15
＜210＞ 1855
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1855
cguuaguaug agugu 15
＜210＞ 1856
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1856
ugagugucgu gcagc 15
＜210＞ 1857
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1857
gagccauagu ggucu 15
＜210＞ 1858
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1858
accggguccu uucuu 15
＜210＞ 1859
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1859
ggguccuuuc uugga 15
＜210＞ 1860
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1860
gguccuuucu uggau 15
＜210＞ 1861
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1861
guccuuucuu ggauc 15
＜210＞ 1862
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1862
cuuggaucaa cccgc 15
＜210＞ 1863
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1863
uggagauuug ggcgu 15
＜210＞ 1864
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1864
ggagauuugg gcgug 15
＜210＞ 1865
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1865
aaggccuugu gguac 15
＜210＞ 1866
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1866
cacgaauccu aaacc 15
＜210＞ 1867
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1867
gaauccuaaa ccuca 15
＜210＞ 1868
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1868
uaaaccucaa agaaa 15
＜210＞ 1869
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1869
caaacguaac accua 15
＜210＞ 1870
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1870
aacaccuacc gccgc 15
＜210＞ 1871
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1871
gucagaucgu uggug 15
＜210＞ 1872
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1872
agaucguugg uggag 15
＜210＞ 1873
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1873
guggaguuua cgugu 15
＜210＞ 1874
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1874
uggaguuuac guguu 15
＜210＞ 1875
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1875
ggaguuuacg uguug 15
＜210＞ 1876
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1876
uacguguugc cgcgc 15
＜210＞ 1877
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1877
gcaaccucgu ggaag 15
＜210＞ 1878
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1878
cggaggucgc gcaau 15
＜210＞ 1879
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1879
ucuggguaag gucau 15
＜210＞ 1880
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1880
auacccucac gugcg 15
＜210＞ 1881
＜211＞ 15
＜212＞ RNA ＜213＞ Hepatitis C Virus
＜400＞ 1881
ccgaccucau ggggu 15
＜210＞ 1882
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1882
uugcucuuuc ucuau 15
＜210＞ 1883
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1883
ugcucuuucu cuauc 15
＜210＞ 1884
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1884
gcucuuucuc uaucu 15
＜210＞ 1885
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1885
ucuuucucua ucuuc 15
＜210＞ 1886
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1886
uuucucuauc uuccu 15
＜210＞ 1887
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1887
ucucuaucuu ccucu 15
＜210＞ 1888
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1888
ucuaucuucc ucuug 15
＜210＞ 1889
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1889
cuaucuuccu cuugg 15
＜210＞ 1890
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1890
ucuuccucuu ggccc 15
＜210＞ 1891
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1891
uuccucuugg cccug 15
＜210＞ 1892
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1892
cugcuguccu guuug 15
＜210＞ 1893
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1893
guccuguuug accau 15
＜210＞ 1894
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1894
uccuguuuga ccauc 15
＜210＞ 1895
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1895
ugaccauccc agcuu 15
＜210＞ 1896
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1896
cccagcuucc gcuua 15
＜210＞ 1897
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1897
ccagcuuccg cuuau 15
＜210＞ 1898
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1898
uuccgcuuau caggu 15
＜210＞ 1899
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1899
uccgcuuauc aggug 15
＜210＞ 1900
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1900
cgcuuaucag gugcg 15
＜210＞ 1901
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1901
aacgcauccg ggcug 15
＜210＞ 1902
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1902
gggcuguacc auguc 15
＜210＞ 1903
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1903
accaugucac gaaug 15
＜210＞ 1904
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1904
gacugcucca acuca 15
＜210＞ 1905
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1905
uccaacucaa gcauu 15
＜210＞ 1906
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1906
caagcauugu guaug 15
＜210＞ 1907
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1907
caugcauacc cccgg 15
＜210＞ 1908
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1908
uagcgcucac uccca 15
＜210＞ 1909
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1909
gcucacuccc acgcu 15
＜210＞ 1910
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1910
ccacgcucgc ggcca 15
＜210＞ 1911
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1911
ccagcauccc cacua 15
＜210＞ 1912
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1912
ccccacuacg acaau 15
＜210＞ 1913
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1913
cgacaauacg acgcc 15
＜210＞ 1914
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1914
ggccgcuuuc uguuc 15
＜210＞ 1915
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1915
gggaccucug cggau 15
＜210＞ 1916
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1916
uuuuccucgu cuccc 15
＜210＞ 1917
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1917
uccucgucuc ccagu 15
＜210＞ 1918
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1918
cucgucuccc aguug 15
＜210＞ 1919
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1919
ucccaguugu ucacc 15
＜210＞ 1920
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1920
caguuguuca ccuuc 15
＜210＞ 1921
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1921
aguuguucac cuucu 15
＜210＞ 1922
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1922
uucaccuucu cgccu 15
＜210＞ 1923
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1923
ucaccuucuc gccuc 15
＜210＞ 1924
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1924
accuucucgc cucgc 15
＜210＞ 1925
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1925
cucgccucgc cggua 15
＜210＞ 1926
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1926
cgccgguaug agaca 15
＜210＞ 1927
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1927
agacaguaca ggacu 15
＜210＞ 1928
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1928
cugcaauugc ucaau 15
＜210＞ 1929
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1929
aauugcucaa ucuau 15
＜210＞ 1930
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1930
gcucaaucua ucccg 15
＜210＞ 1931
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1931
ucaaucuauc ccggc 15
＜210＞ 1932
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1932
aaucuauccc ggcca 15
＜210＞ 1933
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1933
cauggcuugg gauau 15
＜210＞ 1934
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1934
uugggauaug augau 15
＜210＞ 1935
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1935
aacuggucgc cuaca 15
＜210＞ 1936
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1936
gucgccuaca acagc 15
＜210＞ 1937
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1937
cagcccuagu ggugu 15
＜210＞ 1938
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1938
guggugucgc aguua 15
＜210＞ 1939
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1939
ucgcaguuac uccgg 15
＜210＞ 1940
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1940
cgcaguuacu ccgga 15
＜210＞ 1941
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1941
aguuacuccg gaucc 15
＜210＞ 1942
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1942
uccggauccc acaag 15
＜210＞ 1943
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1943
cugggcuaag gucuu 15
＜210＞ 1944
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1944
cuaaggucuu gauug 15
＜210＞ 1945
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1945
aaggucuuga uugug 15
＜210＞ 1946
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1946
ucuugauugu gaugu 15
＜210＞ 1947
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1947
gugauguuac ucuuu 15
＜210＞ 1948
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1948
ugauguuacu cuuug 15
＜210＞ 1949
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1949
uguuacucuu ugccg 15
＜210＞ 1950
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1950
uuacucuuug ccggc 15
＜210＞ 1951
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1951
uacucuuugc cggcg 15
＜210＞ 1952
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1952
ccggcguuga cgggg 15
＜210＞ 1953
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1953
acggggucac uuaca 15
＜210＞ 1954
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1954
ggucacuuac acgac 15
＜210＞ 1955
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1955
gucacuuaca cgaca 15
＜210＞ 1956
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1956
ggggggucgc aagcu 15
＜210＞ 1957
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1957
gcaagcucgc cacac 15
＜210＞ 1958
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1958
agagcgucac guccu 15
＜210＞ 1959
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1959
gucacguccu ucuuc 15
＜210＞ 1960
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1960
acguccuucu ucacc 15
＜210＞ 1961
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1961
cguccuucuu caccc 15
＜210＞ 1962
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1962
uccuucuuca cccaa 15
＜210＞ 1963
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1963
ccuucuucac ccaag 15
＜210＞ 1964
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1964
agagaaucca gcuca 15
＜210＞ 1965
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1965
uccagcucau aaaca 15
＜210＞ 1966
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1966
agcucauaaa cacca 15
＜210＞ 1967
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1967
ggcacaucaa cagga 15
＜210＞ 1968
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1968
aaugaauccc ucaac 15
＜210＞ 1969
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1969
aaucccucaa caccg 15
＜210＞ 1970
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1970
accggguucu uugcc 15
＜210＞ 1971
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1971
ccggguucuu ugccg 15
＜210＞ 1972
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1972
ggguucuuug ccgca 15
＜210＞ 1973
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1973
gguucuuugc cgcac 15
＜210＞ 1974
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1974
gcacuguucu acgca 15
＜210＞ 1975
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1975
cacuguucua cgcac 15
＜210＞ 1976
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1976
cuguucuacg cacac 15
＜210＞ 1977
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1977
cacaaguuca acucg 15
＜210＞ 1978
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1978
acaaguucaa cucgu 15
＜210＞ 1979
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1979
uucaacucgu ccgga 15
＜210＞ 1980
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1980
aacucguccg gaugc 15
＜210＞ 1981
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1981
ugcagcucca ucgac 15
＜210＞ 1982
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1982
caccuauacc gagcc 15
＜210＞ 1983
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1983
cgagccuagg gaccu 15
＜210＞ 1984
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1984
ccuggaucag aggcc 15
＜210＞ 1985
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1985
gaggccuuac ugcug 15
＜210＞ 1986
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1986
ccaguguacu guuuc 15
＜210＞ 1987
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1987
guacuguuuc acccc 15
＜210＞ 1988
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1988
uacuguuuca cccca 15
＜210＞ 1989
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1989
acuguuucac cccaa 15
＜210＞ 1990
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1990
ugcugcuucu caaca 15
＜210＞ 1991
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1991
gcugcuucuc aacaa 15
＜210＞ 1992
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1992
ugcuucucaa caaca 15
＜210＞ 1993
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1993
acuggguuca ccaag 15
＜210＞ 1994
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1994
cuggguucac caaga 15
＜210＞ 1995
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1995
cacggauugc uuucg 15
＜210＞ 1996
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1996
gauugcuuuc ggaag 15
＜210＞ 1997
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1997
auugcuuucg gaagc 15
＜210＞ 1998
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1998
uugcuuucgg aagca 15
＜210＞ 1999
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 1999
aacaccuagg uguau 15
＜210＞ 2000
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2000
uagguguaua guuga 15
＜210＞ 2001
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2001
gguguauagu ugacu 15
＜210＞ 2002
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2002
guauaguuga cuacc 15
＜210＞ 2003
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2003
guugacuacc cauac 15
＜210＞ 2004
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2004
uacccauaca ggcuc 15
＜210＞ 2005
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2005
acaggcucug gcacu 15
＜210＞ 2006
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2006
uggcacuacc ccugc 15
＜210＞ 2007
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2007
gcacugucaa cuuua 15
＜210＞ 2008
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2008
gucaacuuua ccauc 15
＜210＞ 2009
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2009
ucaacuuuac caucu 15
＜210＞ 2010
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2010
caacuuuacc aucuu 15
＜210＞ 2011
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2011
ccaucuuuaa gguua 15
＜210＞ 2012
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2012
caucuuuaag guuag 15
＜210＞ 2013
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2013
uuaagguuag gaugu 15
＜210＞ 2014
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2014
uaagguuagg augua 15
＜210＞ 2015
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2015
aggauguaug ugggg 15
＜210＞ 2016
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2016
cuggacucga ggaga 15
＜210＞ 2017
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2017
agacacuucc cuguu 15
＜210＞ 2018
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2018
gacacuuccc uguuc 15
＜210＞ 2019
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2019
ucccuguucc uucac 15
＜210＞ 2020
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2020
cccuguuccu ucacc 15
＜210＞ 2021
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2021
uguuccuuca ccacc 15
＜210＞ 2022
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2022
guuccuucac caccc 15
＜210＞ 2023
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus ＜400＞ 2023
ccacccuacc ggcuc 15
＜210＞ 2024
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2024
accggcucug uccac 15
＜210＞ 2025
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2025
gcucugucca cuggu 15
＜210＞ 2026
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2026
cacugguuug aucca 15
＜210＞ 2027
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2027
acugguuuga uccac 15
＜210＞ 2028
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2028
guuugaucca ccucc 15
＜210＞ 2029
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2029
gugcaguacc uguac 15
＜210＞ 2030
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2030
uaccuguacg guaua 15
＜210＞ 2031
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2031
guacgguaua ggguc 15
＜210＞ 2032
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2032
acgguauagg gucag 15
＜210＞ 2033
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2033
auagggucag cgguu 15
＜210＞ 2034
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2034
cagcgguugu cuccu 15
＜210＞ 2035
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2035
cgguugucuc cuuug 15
＜210＞ 2036
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2036
guugucuccu uugug 15
＜210＞ 2037
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2037
gucuccuuug ugauc 15
＜210＞ 2038
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2038
ucuccuuugu gauca 15
＜210＞ 2039
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2039
uugugaucaa auggg 15
＜210＞ 2040
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2040
ugggaguaua ucgug 15
＜210＞ 2041
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2041
ggaguauauc guguu 15
＜210＞ 2042
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2042
aguauaucgu guugc 15
＜210＞ 2043
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2043
aucguguugc uuuuc 15
＜210＞ 2044
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2044
uguugcuuuu ccuuc 15
＜210＞ 2045
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2045
guugcuuuuc cuucu 15
＜210＞ 2046
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2046
uugcuuuucc uucuc 15
＜210＞ 2047
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2047
ugcuuuuccu ucucc 15
＜210＞ 2048
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2048
uuuuccuucu ccugg 15
＜210＞ 2049
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2049
uuuccuucuc cuggc 15
＜210＞ 2050
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2050
uccuucuccu ggcgg 15
＜210＞ 2051
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2051
gccugcuugu ggaug 15
＜210＞ 2052
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2052
ugcugauagc ccagg 15
＜210＞ 2053
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2053
gcggcguccc uggcc 15
＜210＞ 2054
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2054
auggcauucu cuccu 15
＜210＞ 2055
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2055
uggcauucuc uccuu 15
＜210＞ 2056
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2056
gcauucucuc cuucc 15
＜210＞ 2057
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2057
auucucuccu uccuu 15
＜210＞ 2058
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2058
cucuccuucc uugug 15
＜210＞ 2059
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2059
ucuccuuccu ugugu 15
＜210＞ 2060
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2060
ccuuccuugu guuuu 15
＜210＞ 2061
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2061
cuuguguuuu ucugu 15
＜210＞ 2062
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2062
uuguguuuuu cugug 15
＜210＞ 2063
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2063
uguguuuuuc ugugc 15
＜210＞ 2064
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2064
guguuuuucu gugcc 15
＜210＞ 2065
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2065
uguuuuucug ugccg 15
＜210＞ 2066
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2066
cgcugcuccu gcucc 15
＜210＞ 2067
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2067
cuggcguuac cacca 15
＜210＞ 2068
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2068
uggcguuacc accac 15
＜210＞ 2069
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2069
gcugcaucgu gugga 15
＜210＞ 2070
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2070
gggugguuuu uguag 15
＜210＞ 2071
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2071
ggugguuuuu guagg 15
＜210＞ 2072
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2072
gugguuuuug uaggu 15
＜210＞ 2073
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2073
ugguuuuugu agguc 15
＜210＞ 2074
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2074
uuuuuguagg ucuaa 15
＜210＞ 2075
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2075
uguaggucua auacu 15
＜210＞ 2076
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2076
uaggucuaau acucu 15
＜210＞ 2077
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2077
gucuaauacu cuuga 15
＜210＞ 2078
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2078
uaauacucuu gaccu 15
＜210＞ 2079
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2079
auacucuuga ccuug 15
＜210＞ 2080
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2080
uugaccuugu cacca 15
＜210＞ 2081
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2081
accuugucac cacac 15
＜210＞ 2082
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2082
ccacacuaca aagug 15
＜210＞ 2083
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2083
aaaguguucc ucgcc 15
＜210＞ 2084
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2084
aaguguuccu cgcca 15
＜210＞ 2085
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2085
uguuccucgc caggc 15
＜210＞ 2086
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2086
ccaggcucau auggu 15
＜210＞ 2087
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2087
ggcucauaug guggu 15
＜210＞ 2088
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2088
auacuuuauc accag 15
＜210＞ 2089
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2089
acuuuaucac caggg 15
＜210＞ 2090
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2090
cagagcuaau cuuug 15
＜210＞ 2091
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2091
agcuaaucuu ugaca 15
＜210＞ 2092
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2092
cuaaucuuug acauu 15
＜210＞ 2093
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2093
uaaucuuuga cauua 15
＜210＞ 2094
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2094
uugacauuac caaac 15
＜210＞ 2095
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2095
ugacauuacc aaacu 15
＜210＞ 2096
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2096
ccaaacuccu gcucg 15
＜210＞ 2097
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2097
uccugcucgc cauuc 15
＜210＞ 2098
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2098
ucgccauucu cgguc 15
＜210＞ 2099
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2099
cgccauucuc ggucc 15
＜210＞ 2100
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2100
ccauucucgg uccgc 15
＜210＞ 2101
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2101
ucucgguccg cucau 15
＜210＞ 2102
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2102
guccgcucau ggugc 15
＜210＞ 2103
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2103
uggugcucca ggcug 15
＜210＞ 2104
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2104
augccguacu uugua 15
＜210＞ 2105
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2105
ccguacuuug uacgc 15
＜210＞ 2106
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2106
cguacuuugu acgcg 15
＜210＞ 2107
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2107
acuuuguacg cgcuc 15
＜210＞ 2108
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2108
acgcgcucag gggcu 15
＜210＞ 2109
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2109
aggggcuuau ucgug 15
＜210＞ 2110
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2110
ggggcuuauu cgugc 15
＜210＞ 2111
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2111
ggcuuauucg ugcau 15
＜210＞ 2112
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2112
gcuuauucgu gcaug 15
＜210＞ 2113
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2113
ugcauguugg ugcgg 15
＜210＞ 2114
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2114
ggaaaguagc cggag 15
＜210＞ 2115
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2115
gacagguacg uacgu 15
＜210＞ 2116
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2116
gguacguacg ucuau 15
＜210＞ 2117
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2117
cguacgucua ugacc 15
＜210＞ 2118
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2118
uacgucuaug accau 15
＜210＞ 2119
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2119
ugaccaucuu acccc 15
＜210＞ 2120
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2120
accaucuuac cccgc 15
＜210＞ 2121
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2121
ccaucuuacc ccgcu 15
＜210＞ 2122
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2122
uggcaguaga gcccg 15
＜210＞ 2123
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2123
ucgucuucuc ugaca 15
＜210＞ 2124
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2124
gucuucucug acaug 15
＜210＞ 2125
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2125
agauacuucu gggac 15
＜210＞ 2126
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2126
gauacuucug ggacc 15
＜210＞ 2127
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2127
ggccgauagc auuga 15
＜210＞ 2128
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2128
auagcauuga agggc 15
＜210＞ 2129
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2129
acggccuacg cccaa 15
＜210＞ 2130
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2130
ggggccuacu ugguu 15
＜210＞ 2131
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2131
gccuacuugg uugca 15
＜210＞ 2132
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2132
acuugguugc auugu 15
＜210＞ 2133
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2133
guugcauugu uacua 15
＜210＞ 2134
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2134
gcauuguuac uagcc 15
＜210＞ 2135
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2135
cauuguuacu agccu 15
＜210＞ 2136
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2136
uguuacuagc cucac 15
＜210＞ 2137
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2137
accaggucga agggg 15
＜210＞ 2138
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2138
acacaaucuu uccug 15
＜210＞ 2139
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2139
acaaucuuuc cuggc 15
＜210＞ 2140
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2140
caaucuuucc uggcg 15
＜210＞ 2141
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2141
aaucuuuccu ggcga 15
＜210＞ 2142
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2142
ccugcguuaa uggug 15
＜210＞ 2143
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2143
cugcguuaau ggugu 15
＜210＞ 2144
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2144
ggaccgucuu ccacg 15
＜210＞ 2145
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2145
accgucuucc acggc 15
＜210＞ 2146
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2146
ccgucuucca cggcg 15
＜210＞ 2147
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2147
gcccaaucac ccaaa 15
＜210＞ 2148
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2148
caaauguaca cuaau 15
＜210＞ 2149
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2149
guacacuaau guaga 15
＜210＞ 2150
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2150
cuaauguaga ccaag 15
＜210＞ 2151
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2151
aagaccucgu cggcu 15
＜210＞ 2152
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2152
accucgucgg cuggc 15
＜210＞ 2153
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2153
cugcgguagc ucgga 15
＜210＞ 2154
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2154
cugacgucau uccgg 15
＜210＞ 2155
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2155
gacccgucuc cuauu 15
＜210＞ 2156
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2156
cccgucuccu auuug 15
＜210＞ 2157
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2157
gucuccuauu ugaag 15
＜210＞ 2158
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2158
cuccuauuug aaggg 15
＜210＞ 2159
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2159
uccuauuuga agggc 15
＜210＞ 2160
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2160
aagggcucuu cgggu 15
＜210＞ 2161
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2161
gggcucuucg ggugg 15
＜210＞ 2162
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2162
guggacuuca uaccc 15
＜210＞ 2163
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2163
uggacuucau acccg 15
＜210＞ 2164
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2164
acuucauacc cguug 15
＜210＞ 2165
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2165
uacccguuga gucua 15
＜210＞ 2166
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2166
guugagucua uggaa 15
＜210＞ 2167
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2167
ugagucuaug gaaac 15
＜210＞ 2168
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2168
ggaaacuacu augcg 15
＜210＞ 2169
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2169
aacuacuaug cgguc 15
＜210＞ 2170
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2170
augcgguccc cgguc 15
＜210＞ 2171
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2171
ccccggucuu cacgg 15
＜210＞ 2172
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2172
ccggucuuca cggac 15
＜210＞ 2173
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2173
cggucuucac ggaca 15
＜210＞ 2174
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2174
gacaacucau cuccc 15
＜210＞ 2175
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2175
aacucaucuc ccccg 15
＜210＞ 2176
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2176
cucaucuccc ccggc 15
＜210＞ 2177
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2177
cggccguacc gcaga 15
＜210＞ 2178
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2178
cagacauucc aagug 15
＜210＞ 2179
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2179
agacauucca agugg 15
＜210＞ 2180
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2180
ggcccaucua cacgc 15
＜210＞ 2181
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2181
cccaucuaca cgcuc 15
＜210＞ 2182
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2182
acacgcuccc acugg 15
＜210＞ 2183
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2183
acaagguacu cgucc 15
＜210＞ 2184
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2184
agguacucgu ccuga 15
＜210＞ 2185
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2185
uacucguccu gaacc 15
＜210＞ 2186
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2186
aacccaucug uugcc 15
＜210＞ 2187
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2187
gccaccuugg guuuu 15
＜210＞ 2188
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2188
cuuggguuuu ggggc 15
＜210＞ 2189
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2189
uuggguuuug gggcg 15
＜210＞ 2190
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2190
uggguuuugg ggcgu 15
＜210＞ 2191
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2191
ggggcguaua ugucu 15
＜210＞ 2192
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2192
ggcguauaug ucuaa 15
＜210＞ 2193
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2193
uauaugucua aggca 15
＜210＞ 2194
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2194
uaugucuaag gcaca 15
＜210＞ 2195
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2195
acaugguacc gaccc 15
＜210＞ 2196
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2196
ggaccauuac cacgg 15
＜210＞ 2197
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2197
gaccauuacc acggg 15
＜210＞ 2198
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2198
cccccaucac guacu 15
＜210＞ 2199
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2199
aucacguacu ccacc 15
＜210＞ 2200
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2200
acguacucca ccuau 15
＜210＞ 2201
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2201
uggauguucu ggggg 15
＜210＞ 2202
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2202
ggauguucug ggggc 15
＜210＞ 2203
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2203
ggcgccuaug auauc 15
＜210＞ 2204
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2204
cuaugauauc auaau 15
＜210＞ 2205
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2205
augauaucau aauau 15
＜210＞ 2206
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2206
ugccacucaa cugac 15
＜210＞ 2207
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2207
acugacucga cuacc 15
＜210＞ 2208
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2208
cucgacuacc auccu 15
＜210＞ 2209
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2209
cuaccauccu gggca 15
＜210＞ 2210
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2210
ugggcaucgg cacag 15
＜210＞ 2211
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2211
caccgcuacg ccucc 15
＜210＞ 2212
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2212
uacgccuccg ggauc 15
＜210＞ 2213
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2213
ccgggaucgg uuacc 15
＜210＞ 2214
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2214
gaucgguuac cgugc 15
＜210＞ 2215
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2215
aucgguuacc gugcc 15
＜210＞ 2216
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2216
caaauauuga ggagg 15
＜210＞ 2217
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2217
gguggcucug uccaa 15
＜210＞ 2218
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2218
auccccuucu auggc 15
＜210＞ 2219
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2219
uccccuucua uggca 15
＜210＞ 2220
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2220
cccuucuaug gcaag 15
＜210＞ 2221
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2221
aaggcaucuc auuuu 15
＜210＞ 2222
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2222
ggcaucucau uuucu 15
＜210＞ 2223
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2223
aucucauuuu cugcc 15
＜210＞ 2224
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2224
ucucauuuuc ugcca 15
＜210＞ 2225
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2225
cucauuuucu gccac 15
＜210＞ 2226
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2226
ucauuuucug ccacu 15
＜210＞ 2227
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2227
augagcucgc cgcaa 15
＜210＞ 2228
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2228
aagcugucag gccuc 15
＜210＞ 2229
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2229
caggccucgg aauca 15
＜210＞ 2230
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2230
ccggggucuu gacgu 15
＜210＞ 2231
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2231
ggggucuuga cgugu 15
＜210＞ 2232
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2232
gacguguccg ucaua 15
＜210＞ 2233
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2233
gagaugucgu uaucg 15
＜210＞ 2234
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2234
augucguuau cgugg 15
＜210＞ 2235
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2235
ugucguuauc guggc 15
＜210＞ 2236
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2236
ucguuaucgu ggcaa 15
＜210＞ 2237
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2237
agacgcucua augac 15
＜210＞ 2238
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2238
acgcucuaau gacgg 15
＜210＞ 2239
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2239
ggugacuuug acucg 15
＜210＞ 2240
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2240
gugacuuuga cucgg 15
＜210＞ 2241
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2241
uuugacucgg ugauc 15
＜210＞ 2242
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2242
caugugucac ccaga 15
＜210＞ 2243
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2243
agacagucga uuuca 15
＜210＞ 2244
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2244
agucgauuuc agcuu 15
＜210＞ 2245
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2245
gucgauuuca gcuug 15
＜210＞ 2246
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2246
ucgauuucag cuugg 15
＜210＞ 2247
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2247
uucagcuugg auccc 15
＜210＞ 2248
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2248
cuuggauccc accuu 15
＜210＞ 2249
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2249
cccaccuuua ccauu 15
＜210＞ 2250
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2250
ccaccuuuac cauug 15
＜210＞ 2251
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2251
caccuuuacc auuga 15
＜210＞ 2252
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2252
uuaccauuga gacga 15
＜210＞ 2253
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2253
cagggguagg ggagg 15
＜210＞ 2254
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2254
gaggcaucua caggu 15
＜210＞ 2255
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2255
ggcaucuaca gguuu 15
＜210＞ 2256
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2256
uacagguuug ugacu 15
＜210＞ 2257
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2257
acagguuugu gacuc 15
＜210＞ 2258
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2258
ugugacuccg ggaga 15
＜210＞ 2259
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2259
cggcccucgg gcaug 15
＜210＞ 2260
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2260
ggcauguucg auucu 15
＜210＞ 2261
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2261
gcauguucga uucuu 15
＜210＞ 2262
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2262
guucgauucu ucggu 15
＜210＞ 2263
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2263
uucgauucuu cgguc 15
＜210＞ 2264
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2264
cgauucuucg guccu 15
＜210＞ 2265
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2265
gauucuucgg uccug 15
＜210＞ 2266
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2266
cuucgguccu gugug 15
＜210＞ 2267
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2267
gagugcuaug acgcg 15
＜210＞ 2268
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2268
cuggaguucu gggaa 15
＜210＞ 2269
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2269
uggaguucug ggaaa 15
＜210＞ 2270
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2270
aaagcgucuu cacag 15
＜210＞ 2271
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2271
agcgucuuca caggc 15
＜210＞ 2272
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2272
gcgucuucac aggcc 15
＜210＞ 2273
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2273
caggccucac ccaca 15
＜210＞ 2274
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2274
cccacauaga ugccc 15
＜210＞ 2275
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2275
gcccacuucc ugucc 15
＜210＞ 2276
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2276
cccacuuccu guccc 15
＜210＞ 2277
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2277
uuccuguccc aaacc 15
＜210＞ 2278
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2278
gacaacuucc cuuac 15
＜210＞ 2279
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2279
acaacuuccc uuacc 15
＜210＞ 2280
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2280
cuucccuuac cuggu 15
＜210＞ 2281
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2281
uucccuuacc uggua 15
＜210＞ 2282
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2282
ucaggcucca ccucc 15
＜210＞ 2283
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2283
uccaccucca ucgug 15
＜210＞ 2284
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2284
ccuccaucgu gggau 15
＜210＞ 2285
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2285
gugggaucaa augug 15
＜210＞ 2286
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2286
gaagugucuc auacg 15
＜210＞ 2287
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2287
agugucucau acggc 15
＜210＞ 2288
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2288
gucucauacg gcuua 15
＜210＞ 2289
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2289
uacggcuuaa accua 15
＜210＞ 2290
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2290
acggcuuaaa ccuac 15
＜210＞ 2291
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2291
uaaaccuacg cugca 15
＜210＞ 2292
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2292
auaggcuagg agccg 15
＜210＞ 2293
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2293
gagccguuca aaaug 15
＜210＞ 2294
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2294
agccguucaa aauga 15
＜210＞ 2295
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2295
augagaucac ccuca 15
＜210＞ 2296
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2296
ucacccucac acauc 15
＜210＞ 2297
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2297
cacacauccc auaac 15
＜210＞ 2298
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2298
aucccauaac caaau 15
＜210＞ 2299
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2299
accaaauuca ucaug 15
＜210＞ 2300
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2300
ccaaauucau caugg 15
＜210＞ 2301
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2301
aauucaucau ggcau 15
＜210＞ 2302
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2302
ugcaugucgg ccgac 15
＜210＞ 2303
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2303
ugcagcucug gccgc 15
＜210＞ 2304
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2304
guguggucau ugugg 15
＜210＞ 2305
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2305
uggucauugu gggua 15
＜210＞ 2306
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2306
uguggguagg aucau 15
＜210＞ 2307
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2307
ggaucauuuu guccg 15
＜210＞ 2308
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2308
gaucauuuug uccgg 15
＜210＞ 2309
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2309
aucauuuugu ccggg 15
＜210＞ 2310
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2310
auuuuguccg ggagg 15
＜210＞ 2311
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2311
gggaaguccu cuacc 15
＜210＞ 2312
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2312
aaguccucua ccggg 15
＜210＞ 2313
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2313
guccucuacc gggag 15
＜210＞ 2314
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2314
cgggaguucg augaa 15
＜210＞ 2315
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2315
gggaguucga ugaaa 15
＜210＞ 2316
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2316
ugcgccucac accuc 15
＜210＞ 2317
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2317
cacaccuccc uuaca 15
＜210＞ 2318
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2318
ccucccuuac aucga 15
＜210＞ 2319
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2319
cucccuuaca ucgaa 15
＜210＞ 2320
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2320
cuuacaucga acagg 15
＜210＞ 2321
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2321
ugcagcucgc cgagc 15
＜210＞ 2322
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2322
aggcacucgg guugc 15
＜210＞ 2323
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2323
cucggguugc ugcaa 15
＜210＞ 2324
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2324
uggaacuuca ucagc 15
＜210＞ 2325
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2325
ggaacuucau cagcg 15
＜210＞ 2326
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2326
acuucaucag cggga 15
＜210＞ 2327
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2327
gcgggauaca guauu 15
＜210＞ 2328
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2328
auacaguauu uagca 15
＜210＞ 2329
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2329
acaguauuua gcagg 15
＜210＞ 2330
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2330
caguauuuag caggc 15
＜210＞ 2331
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2331
aguauuuagc aggcu 15
＜210＞ 2332
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2332
ggcuuaucca cucug 15
＜210＞ 2333
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2333
auccacucug ccugg 15
＜210＞ 2334
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2334
ccgcgauagc aucac 15
＜210＞ 2335
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2335
auagcaucac ugaug 15
＜210＞ 2336
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2336
auggcauuca cagcc 15
＜210＞ 2337
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2337
uggcauucac agccu 15
＜210＞ 2338
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2338
acagccucua ucacc 15
＜210＞ 2339
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2339
agccucuauc accag 15
＜210＞ 2340
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2340
ccucuaucac caguc 15
＜210＞ 2341
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2341
caccaguccg cucac 15
＜210＞ 2342
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2342
guccgcucac caccc 15
＜210＞ 2343
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2343
ccagaauacc cuccu 15
＜210＞ 2344
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2344
auacccuccu guuca 15
＜210＞ 2345
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2345
ucaacaucuu agggg 15
＜210＞ 2346
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2346
aacaucuuag gggga 15
＜210＞ 2347
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2347
acaucuuagg gggau 15
＜210＞ 2348
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2348
ggcugcucaa cucgc 15
＜210＞ 2349
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2349
cgcuccuccc agugc 15
＜210＞ 2350
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2350
ugcugcuucg gccuu 15
＜210＞ 2351
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2351
aggugcuugu ggaca 15
＜210＞ 2352
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2352
uggacauucu ggcgg 15
＜210＞ 2353
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2353
ggacauucug gcggg 15
＜210＞ 2354
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2354
guuaacuugc ucccu 15
＜210＞ 2355
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2355
cugccauccu cuccc 15
＜210＞ 2356
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2356
ccauccucuc ccccg 15
＜210＞ 2357
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2357
ggcugauagc guucg 15
＜210＞ 2358
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2358
uucgcuucgc ggggu 15
＜210＞ 2359
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2359
gcgggguaac cacgu 15
＜210＞ 2360
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2360
accacguuuc cccca 15
＜210＞ 2361
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2361
ccacguuucc cccac 15
＜210＞ 2362
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2362
cacguuuccc ccacg 15
＜210＞ 2363
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2363
acgcacuacg ugccu 15
＜210＞ 2364
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2364
cacguguaac ucaga 15
＜210＞ 2365
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2365
uguaacucag auccu 15
＜210＞ 2366
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2366
cucagauccu cucca 15
＜210＞ 2367
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2367
agauccucuc cagcc 15
＜210＞ 2368
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2368
auccucucca gccuc 15
＜210＞ 2369
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2369
ccagccucac cauca 15
＜210＞ 2370
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2370
ucaccaucac ucagc 15
＜210＞ 2371
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2371
caucacucag cugcu 15
＜210＞ 2372
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2372
agaggcuuca ccagu 15
＜210＞ 2373
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2373
gaggcuucac cagug 15
＜210＞ 2374
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2374
aguggauuaa ugagg 15
＜210＞ 2375
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2375
guggauuaau gagga 15
＜210＞ 2376
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2376
gacugcucca cgcca 15
＜210＞ 2377
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2377
ccaugcuccg gcucg 15
＜210＞ 2378
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2378
uccggcucgu ggcua 15
＜210＞ 2379
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2379
cguggcuaaa ggaug 15
＜210＞ 2380
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2380
aggauguuug ggacu 15
＜210＞ 2381
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2381
ggauguuugg gacug 15
＜210＞ 2382
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2382
acuggauaug cacgg 15
＜210＞ 2383
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2383
acgguguuga cugac 15
＜210＞ 2384
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2384
acugacuuca agacc 15
＜210＞ 2385
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2385
cugacuucaa gaccu 15
＜210＞ 2386
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2386
ccuggcucca gucca 15
＜210＞ 2387
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2387
cuccagucca agcuc 15
＜210＞ 2388
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2388
ccaagcuccu gccga 15
＜210＞ 2389
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2389
ccgaaauugc cggga 15
＜210＞ 2390
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2390
cgggaguccc uuucu 15
＜210＞ 2391
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2391
agucccuuuc uucuc 15
＜210＞ 2392
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2392
gucccuuucu ucuca 15
＜210＞ 2393
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2393
ucccuuucuu cucau 15
＜210＞ 2394
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2394
ccuuucuucu caugc 15
＜210＞ 2395
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2395
cuuucuucuc augcc 15
＜210＞ 2396
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2396
uucuucucau gccaa 15
＜210＞ 2397
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2397
cgcggguaca aggga 15
＜210＞ 2398
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2398
agggagucug gcggg 15
＜210＞ 2399
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2399
cacaaauuac cggac 15
＜210＞ 2400
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2400
acaaauuacc ggaca 15
＜210＞ 2401
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2401
gacaugucaa aaacg 15
＜210＞ 2402
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2402
aaacgguucc augag 15
＜210＞ 2403
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2403
aacgguucca ugagg 15
＜210＞ 2404
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2404
ugaggaucgu ugggc 15
＜210＞ 2405
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2405
ggaucguugg gccua 15
＜210＞ 2406
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2406
ugggccuaaa accug 15
＜210＞ 2407
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2407
ggaacguucc ccauc 15
＜210＞ 2408
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2408
gaacguuccc cauca 15
＜210＞ 2409
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2409
uccccaucaa cgcgu 15
＜210＞ 2410
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2410
aacgcguaca ccaca 15
＜210＞ 2411
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2411
acacccuccc cggcg 15
＜210＞ 2412
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2412
gaagaguacg uggag 15
＜210＞ 2413
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2413
uggagauuac gcggg 15
＜210＞ 2414
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2414
ggagauuacg cgggu 15
＜210＞ 2415
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2415
gacggguaug accac 15
＜210＞ 2416
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2416
gccagguccc ggccc 15
＜210＞ 2417
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2417
gucacauucc agguc 15
＜210＞ 2418
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2418
cagugcucac uucca 15
＜210＞ 2419
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2419
gcucacuucc augcu 15
＜210＞ 2420
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2420
cucacuucca ugcuc 15
＜210＞ 2421
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2421
ccaugcucac cgacc 15
＜210＞ 2422
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2422
gaccccuccc acauu 15
＜210＞ 2423
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2423
cccacauuac agcag 15
＜210＞ 2424
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2424
ccacauuaca gcaga 15
＜210＞ 2425
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2425
gacggcuaaa cguag 15
＜210＞ 2426
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2426
cagcucuuca gcuag 15
＜210＞ 2427
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2427
agcucuucag cuagc 15
＜210＞ 2428
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2428
uucagcuagc caauu 15
＜210＞ 2429
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2429
ugcgccuucc uugaa 15
＜210＞ 2430
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2430
gcgccuuccu ugaag 15
＜210＞ 2431
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2431
ccuuccuuga aggca 15
＜210＞ 2432
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2432
augcacuacc cacca 15
＜210＞ 2433
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2433
caugacuccc cggac 15
＜210＞ 2434
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2434
cugaccucau cgagg 15
＜210＞ 2435
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2435
accucaucga ggcca 15
＜210＞ 2436
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2436
gaaacaucac ccgug 15
＜210＞ 2437
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2437
guggagucag agaau 15
＜210＞ 2438
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2438
agagaauaag guggu 15
＜210＞ 2439
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2439
aggugguaau uuugg 15
＜210＞ 2440
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2440
ugguaauuuu ggacu 15
＜210＞ 2441
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2441
gguaauuuug gacuc 15
＜210＞ 2442
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2442
guaauuuugg acucu 15
＜210＞ 2443
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2443
uuggacucuu ucgac 15
＜210＞ 2444
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2444
ggacucuuuc gaccc 15
＜210＞ 2445
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2445
gacucuuucg acccg 15
＜210＞ 2446
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2446
acucuuucga cccgc 15
＜210＞ 2447
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2447
gaaguauccg uugca 15
＜210＞ 2448
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2448
uauccguugc agcag 15
＜210＞ 2449
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2449
cagagauccu gcgaa 15
＜210＞ 2450
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2450
cgaaaaucca agaag 15
＜210＞ 2451
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2451
aagaaguucc ccccc 15
＜210＞ 2452
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2452
agaaguuccc ccccg 15
＜210＞ 2453
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2453
caacccucca cuguu 15
＜210＞ 2454
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2454
uuagaguccu ggaaa 15
＜210＞ 2455
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2455
gggcccucca auacc 15
＜210＞ 2456
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2456
cuccaauacc gccuc 15
＜210＞ 2457
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2457
accgccucca cggaa 15
＜210＞ 2458
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2458
ggacgguugu ucuga 15
＜210＞ 2459
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2459
cgguuguucu gacag 15
＜210＞ 2460
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2460
gguuguucug acaga 15
＜210＞ 2461
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2461
accgugucuu cugcc 15
＜210＞ 2462
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2462
cgugucuucu gccuu 15
＜210＞ 2463
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2463
gugucuucug ccuug 15
＜210＞ 2464
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2464
ucugccuugg cggag 15
＜210＞ 2465
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2465
ggcagcuccg gaucg 15
＜210＞ 2466
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2466
cgccccuccc gauca 15
＜210＞ 2467
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2467
ucccgaucag accuc 15
＜210＞ 2468
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2468
cagaccucug acgac 15
＜210＞ 2469
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2469
aaagaaucug acguu 15
＜210＞ 2470
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2470
cugacguuga gucgu 15
＜210＞ 2471
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2471
guugagucgu acucc 15
＜210＞ 2472
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2472
gagucguacu ccucc 15
＜210＞ 2473
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2473
auguccuaca caugg 15
＜210＞ 2474
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2474
cccugaucac gccau 15
＜210＞ 2475
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2475
aacgcguuga gcaac 15
＜210＞ 2476
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2476
agcaacucuc ugcug 15
＜210＞ 2477
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2477
caacucucug cugcg 15
＜210＞ 2478
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2478
gcugcgucac cacaa 15
＜210＞ 2479
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2479
acauggucua ugcca 15
＜210＞ 2480
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2480
auggucuaug ccaca 15
＜210＞ 2481
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2481
agaaggucac cuuug 15
＜210＞ 2482
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2482
gucaccuuug acaga 15
＜210＞ 2483
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2483
ucaccuuuga cagac 15
＜210＞ 2484
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2484
acgugcucaa ggaga 15
＜210＞ 2485
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2485
aaggcgucca caguu 15
＜210＞ 2486
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2486
ccacaguuaa ggcua 15
＜210＞ 2487
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2487
cacaguuaag gcuaa 15
＜210＞ 2488
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2488
cuaaacuucu auccg 15
＜210＞ 2489
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2489
uaaacuucua uccgu 15
＜210＞ 2490
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2490
cccacauucg gccaa 15
＜210＞ 2491
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2491
ccacauucgg ccaaa 15
＜210＞ 2492
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2492
aggacguccg gaacc 15
＜210＞ 2493
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2493
ggaaccuauc cagca 15
＜210＞ 2494
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2494
aaccuaucca gcaag 15
＜210＞ 2495
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2495
aggccauuaa ccaca 15
＜210＞ 2496
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2496
ggccauuaac cacau 15
＜210＞ 2497
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2497
caccaauuga cacca 15
＜210＞ 2498
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2498
ccaccaucau ggcaa 15
＜210＞ 2499
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2499
gugaaguuuu cugcg 15
＜210＞ 2500
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2500
ugaaguuuuc ugcgu 15
＜210＞ 2501
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2501
gaaguuuucu gcguc 15
＜210＞ 2502
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2502
aaguuuucug cgucc 15
＜210＞ 2503
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2503
ucugcgucca accgg 15
＜210＞ 2504
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2504
gccagcucgc cuuau 15
＜210＞ 2505
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2505
uuaucguauu cccag 15
＜210＞ 2506
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2506
aucguauucc cagac 15
＜210＞ 2507
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2507
ucguauuccc agacc 15
＜210＞ 2508
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2508
ugggaguucg uguau 15
＜210＞ 2509
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2509
gggaguucgu guaug 15
＜210＞ 2510
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2510
uucguguaug cgaga 15
＜210＞ 2511
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2511
aauggcucuu uacga 15
＜210＞ 2512
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2512
uggcucuuua cgacg 15
＜210＞ 2513
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2513
ggcucuuuac gacgu 15
＜210＞ 2514
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2514
gcucuuuacg acgug 15
＜210＞ 2515
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2515
acguggucuc caccc 15
＜210＞ 2516
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2516
guggucucca cccuu 15
＜210＞ 2517
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2517
ccacccuucc ucagg 15
＜210＞ 2518
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2518
cacccuuccu caggc 15
＜210＞ 2519
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2519
ccuuccucag gccgu 15
＜210＞ 2520
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2520
augggcuccu cguac 15
＜210＞ 2521
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2521
ggcuccucgu acgga 15
＜210＞ 2522
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2522
acggauucca guacu 15
＜210＞ 2523
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2523
caguacucuc cuggg 15
＜210＞ 2524
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2524
aagcccuaug ggcuu 15
＜210＞ 2525
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2525
augggcuucu cguau 15
＜210＞ 2526
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2526
ugggcuucuc guaug 15
＜210＞ 2527
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2527
ggcuucucgu augac 15
＜210＞ 2528
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2528
uucucguaug acacc 15
＜210＞ 2529
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2529
cgcugcuuug acuca 15
＜210＞ 2530
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2530
gcugcuuuga cucaa 15
＜210＞ 2531
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2531
uuugacucaa caguc 15
＜210＞ 2532
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2532
caacagucac ugaga 15
＜210＞ 2533
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2533
gcgacauccg uguug 15
＜210＞ 2534
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2534
uccguguuga ggagu 15
＜210＞ 2535
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2535
gaggagucaa ucuac 15
＜210＞ 2536
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2536
agucaaucua ccaau 15
＜210＞ 2537
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2537
ucaaucuacc aaugu 15
＜210＞ 2538
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2538
ccaauguugu gacuu 15
＜210＞ 2539
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2539
ugugacuugg ccccc 15
＜210＞ 2540
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2540
ccugacuaau ucaaa 15
＜210＞ 2541
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2541
gacuaauuca aaagg 15
＜210＞ 2542
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2542
acuaauucaa aaggg 15
＜210＞ 2543
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2543
cggcaauacc cucac 15
＜210＞ 2544
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2544
auacccucac augcu 15
＜210＞ 2545
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2545
acaugcuacu ugaaa 15
＜210＞ 2546
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2546
ugcuacuuga aagcc 15
＜210＞ 2547
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2547
ugucguuauc uguga 15
＜210＞ 2548
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2548
ucguuaucug ugaaa 15
＜210＞ 2549
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2549
cgagccuacg agucu 15
＜210＞ 2550
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2550
uacgagucuu cacgg 15
＜210＞ 2551
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2551
cgagucuuca cggag 15
＜210＞ 2552
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2552
gagucuucac ggagg 15
＜210＞ 2553
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2553
ggaggcuaug acuag 15
＜210＞ 2554
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2554
uaugacuagg uacuc 15
＜210＞ 2555
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2555
acuagguacu cugcc 15
＜210＞ 2556
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2556
uacgacuugg aguug 15
＜210＞ 2557
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2557
uuggaguuga uaaca 15
＜210＞ 2558
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2558
aguugauaac aucau 15
＜210＞ 2559
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2559
auaacaucau gcucc 15
＜210＞ 2560
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2560
aacgugucgg ucgcg 15
＜210＞ 2561
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2561
ugucggucgc gcacg 15
＜210＞ 2562
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2562
agaguguacu accuc 15
＜210＞ 2563
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2563
guguacuacc ucacu 15
＜210＞ 2564
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2564
acuaccucac ucgug 15
＜210＞ 2565
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2565
ccucacucgu gaucc 15
＜210＞ 2566
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2566
ucgugauccc accac 15
＜210＞ 2567
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2567
gacagcuaga cacac 15
＜210＞ 2568
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2568
acacacucca gucaa 15
＜210＞ 2569
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2569
cuccagucaa cuccu 15
＜210＞ 2570
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2570
gucaacuccu ggcua 15
＜210＞ 2571
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2571
ccuggcuagg caaca 15
＜210＞ 2572
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2572
gcaacaucau caugu 15
＜210＞ 2573
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2573
acaucaucau guaug 15
＜210＞ 2574
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2574
ggaugauuuu gauga 15
＜210＞ 2575
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2575
augauuuuga ugacu 15
＜210＞ 2576
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2576
acucacuucu ucucc 15
＜210＞ 2577
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2577
cucacuucuu cucca 15
＜210＞ 2578
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2578
cacuucuucu ccauc 15
＜210＞ 2579
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2579
acuucuucuc caucc 15
＜210＞ 2580
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2580
uucuucucca uccuu 15
＜210＞ 2581
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2581
ucuccauccu ucuag 15
＜210＞ 2582
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2582
ccauccuucu agccc 15
＜210＞ 2583
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2583
cauccuucua gccca 15
＜210＞ 2584
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2584
uccuucuagc ccagg 15
＜210＞ 2585
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2585
aacagcuuga aaagg 15
＜210＞ 2586
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2586
ggccuguuac uccau 15
＜210＞ 2587
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2587
gccuguuacu ccauu 15
＜210＞ 2588
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2588
uguuacucca uugag 15
＜210＞ 2589
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2589
acuccauuga gccac 15
＜210＞ 2590
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2590
agccacuuga ccuac 15
＜210＞ 2591
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2591
uugaccuacc ucaga 15
＜210＞ 2592
＜211＞ 15＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2592
ccuaccucag aucau 15
＜210＞ 2593
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2593
cucagaucau ucaac 15
＜210＞ 2594
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2594
agaucauuca acgac 15
＜210＞ 2595
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2595
gaucauucaa cgacu 15
＜210＞ 2596
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2596
aacgacucca ugguc 15
＜210＞ 2597
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2597
ccauggucuu agcgc 15
＜210＞ 2598
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2598
auggucuuag cgcau 15
＜210＞ 2599
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2599
uggucuuagc gcauu 15
＜210＞ 2600
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2600
agcgcauucu cacuc 15
＜210＞ 2601
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2601
gcgcauucuc acucc 15
＜210＞ 2602
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2602
gcauucucac uccau 15
＜210＞ 2603
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2603
ucucacucca uaguu 15
＜210＞ 2604
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2604
acuccauagu uacuc 15
＜210＞ 2605
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2605
ccauaguuac ucucc 15
＜210＞ 2606
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2606
cauaguuacu cucca 15
＜210＞ 2607
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2607
aguuacucuc caggu 15
＜210＞ 2608
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2608
uuacucucca gguga 15
＜210＞ 2609
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2609
gugagaucaa uaggg 15
＜210＞ 2610
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2610
gaucaauagg guggc 15
＜210＞ 2611
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2611
gguggcuuca ugccu 15
＜210＞ 2612
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2612
guggcuucau gccuc 15
＜210＞ 2613
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2613
gagacaucgg gccag 15
＜210＞ 2614
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2614
ggcaaguacc ucuuc 15
＜210＞ 2615
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2615
aguaccucuu caacu 15
＜210＞ 2616
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2616
uaccucuuca acugg 15
＜210＞ 2617
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2617
accucuucaa cuggg 15
＜210＞ 2618
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2618
gggcaguaag gacca 15
＜210＞ 2619
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2619
ccaagcucaa acuca 15
＜210＞ 2620
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2620
ucaaacucac uccaa 15
＜210＞ 2621
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2621
acucacucca auccc 15
＜210＞ 2622
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2622
cuccaauccc ggccg 15
＜210＞ 2623
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2623
ugcugguuac agcgg 15
＜210＞ 2624
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2624
gcugguuaca gcggg 15
＜210＞ 2625
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2625
ccugucucgu gcccg 15
＜210＞ 2626
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2626
cgcugguuua ugugg 15
＜210＞ 2627
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2627
gcugguuuau guggu 15
＜210＞ 2628
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2628
cugguuuaug uggug 15
＜210＞ 2629
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2629
aggccauccc cuuuu 15
＜210＞ 2630
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2630
auccccuuuu uuuuu 15
＜210＞ 2631
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2631
cccccaagaa ggggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2632
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2632
cgugaaagaa guagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2633
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2633
ccuggaagaa gcacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2634
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2634
gcauugagaa gguuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2635
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2635
cuaucaagaa guacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2636
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2636
gugggcagaa guagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2637
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2637
ccugugagaa gcggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2638
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2638
ccaacgagaa gaccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2639
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2639
gguugcagaa guucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2640
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2640
ccucggagaa gcgaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2641
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2641
uacccaagaa gagcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2642
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2642
gccgggagaa gcggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2643
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2643
caacuaagaa gggaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2644
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2644
ccggggagaa guggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2645
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2645
cggcgaagaa gcacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2646
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2646
caugagagaa gcgaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2647
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2647
ccgacgagaa gaauaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2648
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2648
aagagcagaa gggcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2649
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2649
caggacagaa gggcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2650
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2650
aaacagagaa gcagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2651
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2651
uggucaagaa ggacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2652
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2652
agcggaagaa gggaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2653
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2653
cugauaagaa gaagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2654
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2654
aguuggagaa gucaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2655
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2655
cccaacagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2656
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2656
gaaagcagaa gcccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2657
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2657
acagaaagaa gccgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2658
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2658
uggcggagaa gaaaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2659
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2659
aaacggagaa gcagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2660
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2660
gaggaaagaa gaucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2661
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2661
gugaacagaa gggaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2662
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2662
cacuagagaa guugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2663
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2663
ugugggagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2664
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2664
auccacagaa gcuuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2665
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2665
ucucugagaa ggccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2666
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2666
uuuaugagaa ggauaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2667
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2667
ugugccagaa gccaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2668
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2668
guucagagaa guccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2669
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2669
gcguagagaa gugcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2670
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2670
cugggcagaa ggacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2671
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2671
agcugcagaa ggccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2672
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2672
cgauggagaa gcagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2673
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2673
aaugccagaa guaaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2674
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2674
gggugaagaa guacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2675
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2675
cacuacagaa gggcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2676
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2676
ggaccgagaa gucgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2677
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2677
gcaccgagaa gaucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2678
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2678
cagcacagaa gucuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2679
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2679
uugagaagaa gcacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2680
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2680
uguggcagaa gcguaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2681
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2681
ccguggagaa ggucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2682
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2682
aaagcaagaa guggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2683
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2683
gcuccgagaa guccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2684
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2684
gcagcgagaa gagcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2685
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2685
agcagcagaa ggcuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2686
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2686
gacagcagaa gcggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2687
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2687
guggacagaa gcagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2688
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2688
gucgugagaa gcagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2689
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2689
ugaaggagaa gggaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2690
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2690
ggacagagaa gguaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2691
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2691
ccagugagaa gagcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2692
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2692
ggagacagaa gcugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2693
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2693
gcgcgcagaa gccaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2694
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2694
uccacaagaa ggcaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2695
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2695
gcuaucagaa gcauaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2696
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2696
cucuagagaa gccuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2697
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2697
aaugccagaa gcucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2698
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2698
guaccaagaa gcacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2699
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2699
aggagcagaa gccaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2700
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2700
agcaggagaa gcggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2701
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2701
agcaggagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2702
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2702
aacgccagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2703
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2703
ugggugagaa gcacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2704
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2704
auggcgagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2705
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2705
ugagcgagaa gagaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2706
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2706
accaugagaa gaccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2707
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2707
gaagacagaa ggcuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2708
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2708
gagacgagaa guccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2709
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2709
ggcggaagaa ggcaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2710
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2710
ccuucgagaa gagaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2711
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2711
gcuaucagaa ggucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2712
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2712
ggcguaagaa gugaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2713
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2713
guggaaagaa guccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2714
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2714
ucuuugagaa ggcgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2715
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2715
cuuuugagaa ggcuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2716
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2716
caugccagaa gacgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2717
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2717
auagagagaa gagcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2718
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2718
aaugacagaa gcauaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2719
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2719
caccgcagaa gcgcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2720
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2720
ucccccagaa gucaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2721
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2721
cuggggagaa guagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2722
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2722
agacggagaa ggggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2723
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2723
auaggaagaa ggucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2724
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2724
gggcagagaa guggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2725
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2725
ccgaagagaa gagcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2726
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2726
gcacacagaa gcccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2727
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2727
agacucagaa gguaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2728
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2728
accgggagaa gcauaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2729
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2729
cgugaaagaa ggggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2730
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2730
cgguacagaa ggggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2731
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2731
guacgcagaa ggcaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2732
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2732
cccuugagaa gcguaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2733
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2733
ggcggcagaa gaugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2734
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2734
guugggagaa guacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2735
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2735
uccaccagaa gcaaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2736
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2736
agucgaagaa guugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2737
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2737
guccagagaa gugcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2738
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2738
cgcuccagaa gucuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2739
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2739
acgacgagaa gcgcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2740
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2740
guguugagaa gagcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2741
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2741
ccgcuaagaa guauaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2742
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2742
uagagcagaa guugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2743
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2743
gaaaucagaa gucuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2744
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2744
gauccaagaa gaaaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2745
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2745
cccgagagaa guucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2746
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2746
acacagagaa gaagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2747
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2747
agucucagaa ggcgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2748
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2748
cuggcaagaa ggcaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2749
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2749
guuuggagaa ggaaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2750
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2750
gguuuaagaa guauaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2751
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2751
cuauacagaa ggggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2752
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2752
auuuugagaa gcucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2753
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2753
caggucagaa gacaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2754
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2754
cuccagagaa gccgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2755
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2755
ggccagagaa gcaaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2756
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2756
aacaacagaa ggccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2757
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2757
gggaacagaa gccgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2758
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2758
ucggcgagaa gcauaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2759
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2759
ugcuugagaa gcucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2760
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2760
gggagcagaa gccuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2761
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2761
cacgggagaa gcggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2762
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2762
uucccaagaa gaguaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2763
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2763
aaugccagaa gugaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2764
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2764
gauagaagaa gugaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2765
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2765
ugagcgagaa ggugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2766
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2766
guggugagaa gacuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2767
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2767
auguugagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2768
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2768
gaguugagaa gccaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2769
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2769
ggccgaagaa gcacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2770
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2770
cacgaaagaa gaagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2771
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2771
guccucagaa gaggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2772
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2772
gcuaucagaa gguuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2773
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2773
gagaggagaa gaguaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2774
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2774
uggugaagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2775
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2775
uucagcagaa gaguaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2776
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2776
cucuucagaa gcugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2777
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2777
gcguggagaa guccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2778
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2778
gccacgagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2779
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2779
cuugaaagaa gucaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2780
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2780
agcuugagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2781
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2781
aauuucagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2782
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2782
cacaugagaa ggugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2783
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2783
ucauggagaa guuuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2784
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2784
cucuucagaa gccaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2785
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2785
uucgggagaa gggaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2786
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2786
cugugcagaa gcacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2787
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2787
ggagagagaa gcacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2788
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2788
caugggagaa gugaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2789
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2789
ugccacagaa gguuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2790
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2790
ggagggagaa gugaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2791
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2791
cugaagagaa ggccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2792
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2792
gucagcagaa ggggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2793
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2793
gaugagagaa gcguaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2794
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2794
gcucgaagaa ggucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2795
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2795
ugcugcagaa gauaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2796
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2796
guuguaagaa gggcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2797
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2797
gacguaagaa ggacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2798
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2798
gugguaagaa gcaaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2799
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2799
cguggaagaa guauaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2800
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2800
cagaacagaa guccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2801
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2801
cgccaaagaa gaagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2802
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2802
auccggagaa gccgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2803
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2803
ccgacgagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2804
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2804
gucaacagaa gacgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2805
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2805
gcugucagaa gccgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2806
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2806
gggaggagaa gucgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2807
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2807
ggucugagaa ggagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2808
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2808
ucagagagaa gaucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2809
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2809
accgucagaa gaggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2810
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2810
cucaacagaa gauuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2811
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2811
gcugagagaa ggguaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2812
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2812
uugagcagaa gacgaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2813
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2813
acauugagaa gcagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2814
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2814
ggcgugagaa gggcaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2815
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2815
uugaugagaa gcuuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2816
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2816
ugacgcagaa gagaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2817
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2817
cuugcaagaa gucaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2818
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2818
gggggcagaa gcuuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2819
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2819
acacggagaa gaugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2820
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2820
ucuuccagaa ggucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2821
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2821
aaggcgagaa ggcuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2822
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2822
ucccagagaa gggaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2823
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2823
acuggaagaa guacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2824
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2824
caaagcagaa ggugaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2825
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2825
agucaaagaa gcggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2826
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2826
auguagagaa gcucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2827
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2827
gaauuaagaa ggggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2828
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2828
cuagucagaa gcacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2829
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2829
ucgacaagaa gcagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2830
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2830
cagcucagaa ggccaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2831
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2831
ggggggagaa gaguaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2832
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2832
gguuggagaa ggucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2833
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2833
gugcgcagaa gacaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2834
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2834
uuuucaagaa guucaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2835
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2835
ccguagagaa gacaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2836
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2836
ugaaugagaa gaggaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2837
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2837
cgcaagagaa guacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2838
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2838
ccuuggagaa guagaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2839
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2839
ggacgcagaa gggaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2840
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2840
aaguccagaa gggaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2841
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2841
cgaaccagaa ggacaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2842
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2842
gagacaagaa gugaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2843
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2843
gcacgaagaa ggcuaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2844
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2844
agcgggagaa ggcaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2845
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2845
uaaaccagaa ggguaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2846
＜211＞ 42
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Hairpin Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.
＜400＞ 2846
uuggggagaa gguaaccaga gaaacangua cauuaccugg ua 42
＜210＞ 2847
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2847
cccccgauug gggg 14
＜210＞ 2848
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2848
cuacugucuu cacg 14
＜210＞ 2849
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2849
gugcagccuc cagg 14
＜210＞ 2850
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2850
aacccgcuca augc 14
＜210＞ 2851
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2851
guacugccug auag 14
＜210＞ 2852
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2852
cuaccgccgc ccac 14
＜210＞ 2853
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2853
ccgccgccca cagg 14
＜210＞ 2854
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2854
ggucagaucg uugg 14
＜210＞ 2855
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2855
gaacggucgc aacc 14
＜210＞ 2856
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2856
ucgccgaccc gagg 14
＜210＞ 2857
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2857
gcucagccug ggua 14
＜210＞ 2858
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2858
ccgcggcucc cggc 14
＜210＞ 2859
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2859
ucccggccua guug 14
＜210＞ 2860
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2860
ccacggaccc ccgg 14
＜210＞ 2861
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2861
gugcggcuuc gccg 14
＜210＞ 2862
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2862
ucgccgaccu caug 14
＜210＞ 2863
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2863
auuccgcucg ucgg 14
＜210＞ 2864
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2864
gcccgguugc ucuu 14
＜210＞ 2865
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2865
gcccugcugu ccug 14
＜210＞ 2866
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2866
cugcuguccu guuu 14
＜210＞ 2867
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2867
guccuguuug acca 14
＜210＞ 2868
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2868
ucccagcuuc cgcu 14
＜210＞ 2869
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2869
cuuccgcuua ucag 14
＜210＞ 2870
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2870
ugacugcucc aacu 14
＜210＞ 2871
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2871
cucccguugu uggg 14
＜210＞ 2872
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2872
gggcggccgc uuuc 14
＜210＞ 2873
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2873
cggccgcuuu cugu 14
＜210＞ 2874
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2874
uuucuguucc gcca 14
＜210＞ 2875
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2875
cugcggaucc guuu 14
＜210＞ 2876
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2876
gauccguuuu ccuc 14
＜210＞ 2877
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2877
ucccaguugu ucac 14
＜210＞ 2878
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2878
caacagcccu agug 14
＜210＞ 2879
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2879
cuccggaucc caca 14
＜210＞ 2880
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2880
aagcugucgu ggau 14
＜210＞ 2881
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2881
ggccggccca gaga 14
＜210＞ 2882
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2882
auccagcuca uaaa 14
＜210＞ 2883
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2883
uggcagcugg caca 14
＜210＞ 2884
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2884
ggacugcccu gaac 14
＜210＞ 2885
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2885
gcacuguucu acgc 14
＜210＞ 2886
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2886
guccggaugc ccag 14
＜210＞ 2887
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2887
ggccagcugc agcu 14
＜210＞ 2888
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2888
cugcagcucc aucg 14
＜210＞ 2889
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2889
uuacugcugg cauu 14
＜210＞ 2890
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2890
guacuguuuc accc 14
＜210＞ 2891
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2891
gcccuguugu agug 14
＜210＞ 2892
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2892
cgaccgaucg gucc 14
＜210＞ 2893
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2893
gaucgguccg gugc 14
＜210＞ 2894
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2894
agacagaugu gcug 14
＜210＞ 2895
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2895
gugcugcuuc ucaa 14
＜210＞ 2896
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2896
acgcggccgc caca 14
＜210＞ 2897
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2897
gaccugcccc acgg 14
＜210＞ 2898
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2898
ccacggauug cuuu 14
＜210＞ 2899
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2899
ggacagaucg gagc 14
＜210＞ 2900
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2900
gcucagcccg cugc 14
＜210＞ 2901
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2901
agcccgcugc ugcu 14
＜210＞ 2902
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2902
ccgcugcugc uguc 14
＜210＞ 2903
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2903
cugcugcugu ccac 14
＜210＞ 2904
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2904
cugcugucca cgac 14
＜210＞ 2905
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2905
ucccuguucc uuca 14
＜210＞ 2906
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2906
uaccggcucu gucc 14
＜210＞ 2907
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2907
gcucugucca cugg 14
＜210＞ 2908
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2908
cagcgguugu cucc 14
＜210＞ 2909
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2909
uggcggacgc gcgc 14
＜210＞ 2910
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2910
ugccugcuug ugga 14
＜210＞ 2911
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2911
augcugcuga uagc 14
＜210＞ 2912
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2912
aggccgcccu agag 14
＜210＞ 2913
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2913
gagcggaugg cauu 14
＜210＞ 2914
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2914
gugccgccug guac 14
＜210＞ 2915
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2915
uggccgcugc uccu 14
＜210＞ 2916
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2916
ccgcugcucc ugcu 14
＜210＞ 2917
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2917
cuccugcucc ugcu 14
＜210＞ 2918
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2918
cuccugcugg cguu 14
＜210＞ 2919
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2919
gugcggccca ccca 14
＜210＞ 2920
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2920
cuccugcucg ccau 14
＜210＞ 2921
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2921
ucucgguccg cuca 14
＜210＞ 2922
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2922
gguccgcuca uggu 14
＜210＞ 2923
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2923
agcccgucgu cuuc 14
＜210＞ 2924
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2924
ggacugcccg ucuc 14
＜210＞ 2925
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2925
ugcccgucuc cgcc 14
＜210＞ 2926
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2926
ucuccgcccg aagg 14
＜210＞ 2927
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2927
gaccggccga uagc 14
＜210＞ 2928
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2928
ucacggccua cgcc 14
＜210＞ 2929
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2929
ggaccgucuu ccac 14
＜210＞ 2930
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2930
cgccggcuca aaga 14
＜210＞ 2931
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2931
agccggccca aaag 14
＜210＞ 2932
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2932
cgucggcugg caug 14
＜210＞ 2933
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2933
gcucggaccu cuau 14
＜210＞ 2934
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2934
augcugacgu cauu 14
＜210＞ 2935
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2935
gcgccgacgc ggug 14
＜210＞ 2936
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2936
ugacggucgg ggga 14
＜210＞ 2937
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2937
cuacuguccc ccag 14
＜210＞ 2938
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2938
ccccagaccc gucu 14
＜210＞ 2939
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2939
gacccgucuc cuau 14
＜210＞ 2940
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2940
ccacugcucu gccc 14
＜210＞ 2941
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2941
gcucugcccu ucgg 14
＜210＞ 2942
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2942
gggcugcugu gugc 14
＜210＞ 2943
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2943
uacccguuga gucu 14
＜210＞ 2944
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2944
augcgguccc cggu 14
＜210＞ 2945
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2945
ccccggucuu cacg 14
＜210＞ 2946
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2946
ccccggccgu accg 14
＜210＞ 2947
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2947
ugccggcugc guac 14
＜210＞ 2948
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2948
acgcagccca aggg 14
＜210＞ 2949
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2949
caucuguugc cgcc 14
＜210＞ 2950
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2950
guaccgaccc caac 14
＜210＞ 2951
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2951
uugccgacgg ugga 14
＜210＞ 2952
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2952
caacugacuc gacu 14
＜210＞ 2953
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2953
gcacaguccu ggac 14
＜210＞ 2954
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2954
agacggcugg agcg 14
＜210＞ 2955
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2955
gcgcggcucg ucgu 14
＜210＞ 2956
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2956
gcucugucca acac 14
＜210＞ 2957
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2957
auaccgacua gcgg 14
＜210＞ 2958
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2958
caacagacgc ucua 14
＜210＞ 2959
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2959
agacagucga uuuc 14
＜210＞ 2960
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2960
uuucagcuug gauc 14
＜210＞ 2961
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2961
gaacggcccu cggg 14
＜210＞ 2962
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2962
cuucgguccu gugu 14
＜210＞ 2963
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2963
cgcccgcuga gacu 14
＜210＞ 2964
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2964
ugcccgucug ccag 14
＜210＞ 2965
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2965
uuccuguccc aaac 14
＜210＞ 2966
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2966
auacggcuua aacc 14
＜210＞ 2967
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2967
ccccugcugu auag 14
＜210＞ 2968
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2968
gagccguuca aaau 14
＜210＞ 2969
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2969
ugucggccga ccug 14
＜210＞ 2970
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2970
cggccgaccu ggag 14
＜210＞ 2971
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2971
uugcagcucu ggcc 14
＜210＞ 2972
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2972
ggccggcugu uguu 14
＜210＞ 2973
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2973
cggcuguugu uccc 14
＜210＞ 2974
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2974
augcagcucg ccga 14
＜210＞ 2975
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2975
gagcaguuca agca 14
＜210＞ 2976
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2976
aggccgcugc uccc 14
＜210＞ 2977
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2977
ccgcugcucc cgug 14
＜210＞ 2978
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2978
acucugccug ggaa 14
＜210＞ 2979
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2979
ucacugaugg cauu 14
＜210＞ 2980
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2980
ucacagccuc uauc 14
＜210＞ 2981
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2981
caccaguccg cuca 14
＜210＞ 2982
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2982
aguccgcuca ccac 14
＜210＞ 2983
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2983
cuccuguuca acau 14
＜210＞ 2984
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2984
uggcugcuca acuc 14
＜210＞ 2985
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2985
gugcugcuuc ggcc 14
＜210＞ 2986
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2986
cuucggccuu cgug 14
＜210＞ 2987
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2987
ccuccgccga ggac 14
＜210＞ 2988
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2988
aaccggcuga uagc 14
＜210＞ 2989
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2989
acucagaucc ucuc 14
＜210＞ 2990
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2990
cuccagccuc acca 14
＜210＞ 2991
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2991
acucagcugc ugaa 14
＜210＞ 2992
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2992
cagcugcuga agag 14
＜210＞ 2993
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2993
ggacugcucc acgc 14
＜210＞ 2994
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2994
cuccggcucg uggc 14
＜210＞ 2995
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2995
ugacugacuu caag 14
＜210＞ 2996
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2996
cuccagucca agcu 14
＜210＞ 2997
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2997
cuccugccga aauu 14
＜210＞ 2998
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2998
caccugccca ugug 14
＜210＞ 2999
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 2999
aaacgguucc auga 14
＜210＞ 3000
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3000
uggcugcuga agag 14
＜210＞ 3001
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3001
ucccggcccc cgaa 14
＜210＞ 3002
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3002
gugcgguugc acag 14
＜210＞ 3003
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3003
gugcagaccu cucc 14
＜210＞ 3004
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3004
ucacagcucc caug 14
＜210＞ 3005
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3005
aaccggaugu ggca 14
＜210＞ 3006
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3006
ucaccgaccc cucc 14
＜210＞ 3007
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3007
ggccagcucu ucag 14
＜210＞ 3008
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3008
ccccggacgc ugac 14
＜210＞ 3009
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3009
acgcugaccu cauc 14
＜210＞ 3010
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3010
gacccgcuuc gagc 14
＜210＞ 3011
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3011
uauccguugc agca 14
＜210＞ 3012
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3012
gcccggauua caac 14
＜210＞ 3013
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3013
guccggacua cguc 14
＜210＞ 3014
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3014
uugccgccua ccac 14
＜210＞ 3015
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3015
auaccgccuc cacg 14
＜210＞ 3016
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3016
ggacgguugu ucug 14
＜210＞ 3017
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3017
cuucugccuu ggcg 14
＜210＞ 3018
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3018
cggcagcucc ggau 14
＜210＞ 3019
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3019
cuccggaucg ucgg 14
＜210＞ 3020
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3020
cgucggccgu ugac 14
＜210＞ 3021
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3021
cggccguuga cagc 14
＜210＞ 3022
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3022
cgaccgcccc uccc 14
＜210＞ 3023
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3023
cucccgauca gacc 14
＜210＞ 3024
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3024
gaucagaccu cuga 14
＜210＞ 3025
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3025
ccucugacga cggu 14
＜210＞ 3026
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3026
aaucugacgu ugag 14
＜210＞ 3027
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3027
acccugaucu cagc 14
＜210＞ 3028
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3028
cgucugcugc ucaa 14
＜210＞ 3029
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3029
cugcugcuca augu 14
＜210＞ 3030
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3030
gcccugauca cgcc 14
＜210＞ 3031
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3031
aagcugccca ucaa 14
＜210＞ 3032
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3032
ucucugcugc guca 14
＜210＞ 3033
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3033
ugacagacug caag 14
＜210＞ 3034
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3034
aagcugacgc cccc 14
＜210＞ 3035
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3035
cauccgcucc gugu 14
＜210＞ 3036
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3036
gaccugcugg aaga 14
＜210＞ 3037
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3037
agccagcucg ccuu 14
＜210＞ 3038
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3038
ucccagaccu ggga 14
＜210＞ 3039
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3039
guacggauuc cagu 14
＜210＞ 3040
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3040
cacccgcugc uuug 14
＜210＞ 3041
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3041
ccgcugcuuu gacu 14
＜210＞ 3042
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3042
gagcggcucu acau 14
＜210＞ 3043
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3043
ccccugacua auuc 14
＜210＞ 3044
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3044
gugcugacga cuag 14
＜210＞ 3045
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3045
cugcggccug ucga 14
＜210＞ 3046
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3046
ggccugucga gcug 14
＜210＞ 3047
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3047
acucugcccc cccc 14
＜210＞ 3048
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3048
gacccgcccc aacc 14
＜210＞ 3049
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3049
ugucggucgc gcac 14
＜210＞ 3050
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3050
gaacagcuug aaaa 14
＜210＞ 3051
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3051
ugucagaucu acgg 14
＜210＞ 3052
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3052
ccucagauca uuca 14
＜210＞ 3053
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3053
guaccgcccu ugcg 14
＜210＞ 3054
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3054
cuacuguccc aagg 14
＜210＞ 3055
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3055
ucccggccgc gucc 14
＜210＞ 3056
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3056
ucccagcugg acuu 14
＜210＞ 3057
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3057
guccagcugg uucg 14
＜210＞ 3058
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3058
ucacagccug ucuc 14
＜210＞ 3059
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3059
agccugucuc gugc 14
＜210＞ 3060
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3060
ugcccgaccc cgcu 14
＜210＞ 3061
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3061
accccgcugg uuua 14
＜210＞ 3062
＜211＞ 14
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3062
uaccugcucc ccaa 14
＜210＞ 3063
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3063
uuggugucug augagncgaa acguuug 27
＜210＞ 3064
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3064
ugugggccug augagncgaa acgguug 27
＜210＞ 3065
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3065
agguugucug augagncgaa accgcuc 27
＜210＞ 3066
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3066
aaaaaaacug augagncgaa aaaaaaa 27
＜210＞ 3067
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3067
uaagaugcug augagncgaa agccacc 27
＜210＞ 3068
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3068
gggcuaacug augagncgaa auggagc 27
＜210＞ 3069
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3069
uagggcucug augagncgaa agaugga 27
＜210＞ 3070
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3070
cuagggccug augagncgaa aagaugg 27
＜210＞ 3071
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3071
ccgugaccug augagncgaa agggcua 27
＜210＞ 3072
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3072
uagccgucug augagncgaa acuaggg 27
＜210＞ 3073
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3073
ucacagccug augagncgaa agccgug 27
＜210＞ 3074
＜211＞ 27
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme
＜220＞
＜223＞ The letter "n" represents the stem II region of a HH ribozyme.
＜400＞ 3074
gcucacgcug augagncgaa accuuuc 27
＜210＞ 3075
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3075
caaacguaac accaa 15
＜210＞ 3076
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3076
caaccgucgc ccaca 15
＜210＞ 3077
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3077
gagcggucac aaccu 15
＜210＞ 3078
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3078
uuuuuuuuuu uuuuu 15
＜210＞ 3079
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3079
gguggcucca ucuua 15
＜210＞ 3080
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3080
gcuccaucuu agccc 15
＜210＞ 3081
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3081
uccaucuuag cccua 15
＜210＞ 3082
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3082
ccaucuuagc ccuag 15
＜210＞ 3083
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3083
uagcccuagu cacgg 15
＜210＞ 3084
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3084
cccuagucac ggcua 15
＜210＞ 3085
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3085
cacggcuagc uguga 15
＜210＞ 3086
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3086
gaaagguccg ugagc 15
＜210＞ 3087
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3087
auccuugaug gcauacacua ugcgcgauga ucugca 36
＜210＞ 3088
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3088
acacuugaug gcaugcacua ugcgcgauac uaacgc 36
＜210＞ 3089
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3089
cacgaugaug gcaugcacua ugcgcgacuc auacua 36
＜210＞ 3090
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3090
ggcugugaug gcaugcacua ugcgcgacga cacuca 36
＜210＞ 3091
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3091
cccaaugaug gcaugcacua ugcgcgacua cucggc 36
＜210＞ 3092
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3092
uuucgugaug gcaugcacua ugcgcggacc caacac 36
＜210＞ 3093
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3093
ucaggugaug gcaugcacua ugcgcgagua ccacaa 36
＜210＞ 3094
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3094
gcacuugaug gcaugcacua ugcgcggcaa gcaccc 36
＜210＞ 3095
＜211＞ 32
＜212＞ RNA
＜213＞ Artificial Sequence ＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3095
auuccacnag ugaggcguua gccgauacgc ga 32
＜210＞ 3096
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜220＞
＜223＞ The letter "n" in position 9 represents 2'-C-Allyl-U;
The letter "n" in position 30 represents a ribo inosine.
＜400＞ 3096
uccucaccng augaggccgu uaggccgaan gggagu 36
＜210＞ 3097
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜220＞
＜223＞ The letter "n" in position 9 represents an 2'-C-Allyl-U;
The letter "n" in position 30 represents a ribo inosine.
＜400＞ 3097
guccuggcng augaggccgu uaggccgaan gcugca 36
＜210＞ 3098
＜211＞ 53
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3098
ggaaaggugu gcaaccggag gaaacucccu ucaaggacau cguccgggac ggc 53
＜210＞ 3099
＜211＞ 50
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3099
uuccgcagac ggaggaaacu cccuucaagg acgaaagucc gggacuaugg 50
＜210＞ 3100
＜211＞ 48
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3100
ccgcagacgg aggaaacucc cuucaaggac gaaaguccgg gacuaugg 48
＜210＞ 3101
＜211＞ 48
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3101
cagguaguac ggaggaaacu cccuucaagg acaucguccg ggacaagg 48
＜210＞ 3102
＜211＞ 48
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3102
gcacggucua ggaggaaacu cccuucaagg acaucguccg gggagacc 48
＜210＞ 3103
＜211＞ 47
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Ribozyme Motifs
＜400＞ 3103
guguacucac ggaggaaacu cccuucaagg acaucguccg gggguuc 47
＜210＞ 3104
＜211＞ 23
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized nucleic acid molecule
＜400＞ 3104
gaaaugcaaa guuccagaau cgg 23
＜210＞ 3105
＜211＞ 17
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized nucleic acid molecule
＜400＞ 3105
uccucgcugg ggcuaag 17
＜210＞ 3106
＜211＞ 13
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized nucleic acid molecule
＜220＞
＜223＞ The letter "n" stands for any base.
＜400＞ 3106
cugangagcg aaa 13
＜210＞ 3107
＜211＞ 15
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized nucleic acid molecule
＜220＞
＜223＞ The letter "n" stands for any base;
The letter "y" stands for c or u;
The letter "h" stands for a, c or u.
＜400＞ 3107
nnnnnnnyng hynnn 15
＜210＞ 3108
＜211＞ 47
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized nucleic acid molecule
＜220＞
＜223＞ The letter "n" stands for any base;
The letter "h" stands for a, c or u.
＜400＞ 3108
nnnngaagnn nnnnnnnnna aahannnnnn nacauuacnn nnnnnnn 47
＜210＞ 3109
＜211＞ 15
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3109
ggguccuuuc uugga 15
＜210＞ 3110
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 3110
uccaagacug augaggccgu uaggccgaaa ggaccc 36
＜210＞ 3111
＜211＞ 34
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 3111
uccaagacug augaggcguu agccgaaagg accc 34
＜210＞ 3112
＜211＞ 13
＜212＞ RNA
＜213＞ Hepatitis C Virus
＜400＞ 3112
gguccuuucu ugg 13
＜210＞ 3113
＜211＞ 34
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 3113
ccaagacuga ugaggccguu aggccgaaag gacc 34
＜210＞ 3114
＜211＞ 32
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized Hammerhead Ribozyme
＜400＞ 3114
ccaagacuga ugaggcguua gccgaaagga cc 32
＜210＞ 3115
＜211＞ 54
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized nucleic acid molecule
＜220＞
＜223＞ The letter "n" stands for any base
＜400＞ 3115
nnnnnnnnnn nnnnnnggag gaaacucccu ucaaggacga aaguccgggn nnnn 54
＜210＞ 3116
＜211＞ 18
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized nucleic acid molecule
＜220＞
＜223＞ The letter "n" stands for any base
＜400＞ 3116
nnnnngnnnn nnnnnnnn 18
＜210＞ 3117
＜211＞ 35
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized nucleic acid molecule
＜220＞
＜223＞ The letter "n" stands for any base
＜400＞ 3117
nnnnnnncug augagnnnga aannncgaan nnnnn 35
＜210＞ 3118
＜211＞ 36
＜212＞ RNA
＜213＞ Artificial Sequence
＜220＞
＜223＞ Synthesized nucleic acid molecule
＜220＞
＜223＞ The letter "n" stands for any base;
The letter "s" stands for c or g.
＜400＞ 3118
nnnnnnnuga usgggaugaa cuauccgcgn nnnnnn 36
본 특허 출원은 블랫(Blatt) 등의 1999년 2월 24일 출원된 미국 출원(번호 미지정), 블랫(Blatt) 등의 1998년 9월 18일 출원된 미국 특허 제 60/100,842호, 및 맥스위겐(McSwiggen) 등의 1998년 4월 27일 출원된 미국 특허 제 60/083,217호에 대하여 우선권을 주장하며, 이들 이전의 출원의 명칭은 모두 "C형 간염 바이러스성 감염과 관련된 질환의 효소적 핵산 치료제"이다. 이들 출원 각각은 도면을 포함한 전문이 본원에 참고문헌으로 삽입된다.
발명의 배경
본 발명은 C형 간염 바이러스성 감염과 관련된 질환의 치료 방법 및 치료제에 관한 것이다.
하기 설명은 본 발명보다 선행되는 것으로 인정되지 않는 관련 기술에 관한 검토이다.
1989년, HCV는 RNA 바이러스로 결정되었고 대부분의 비-A 비-B형 바이러스성 간염의 원인 인자로서 확인되었다[참조: Choo et al., Science. 1989; 244: 359-362]. HIV와 같은 레트로바이러스와는 달리, HCV는 DNA 복제기를 거치지 않으며 숙주 염색체에 혼입된 형태의 바이러스 게놈은 검출되지 않았다[참조: Houghton et al., Hepatology 1991; 14: 381-388]. 오히려, 코딩(+) 가닥의 복제는 (+) 가닥 HCV RNA의 수개의 복제물을 생성시키는 복제성(-) 가닥의 생성에 의해 매개된다. 게놈은 폴리단백질로 번역되는 단일의 거대한 개방 해독 구조로 구성된다[Kato et al., FEBS Letters. 1991; 280: 325-328]. 이 폴리단백질은 후속하여 번역후 절단을 거쳐 수개의 바이러스 단백질을 생성한다[참조: Leinbach et al., 1994: 204: 163-169].
HCV의 9.5 킬로베이스 게놈의 조사결과 바이러스 핵산은 고비율로 돌연변이할 수 있는 것으로 증명되었다[Smith et al., Mol. Evol. 1997 45: 238-246]. 이러한 돌연변이 비율은 약 70%의 서열 동일성을 공유하는 HCV의 수개의 상이한 제노타입의 진화를 초래하였다[참조: Simmonds et al., J. Gen. Virol. 1994; 75: 1053-1061]. 중요한 것은 이러한 서열이 진화론적으로 관계가 매우 멀다는 것이다. 예컨대, 인간과 침팬지와 같은 영장류 사이의 유전학적 동일성은 약 98%이다. 또한, 개개 환자에서 HCV 감염은 RNA 수준에서 98%의 동일성을 가지는 수개의 상이한 진화성 유사종으로 구성되는 것이 증명되었다. 따라서, HCV 게놈은 초가변성이고 연속적으로 변화한다. HCV 게놈이 초가변성일지라도, 고도로 보존되는 3개 영역의 게놈이 있다. 이들 보존되는 서열은 5' 및 3' 비코딩 영역 뿐만 아니라 5' 말단의 가운데 단백질 코딩 영역에 존재하고 HCV RNA 복제 뿐만 아니라 HCV 폴리단백질의 번역에 중요한 것으로 생각된다. 따라서, 이러한 보존되는 HCV 게놈 영역을 표적화하는 치료제는 광범위한 HCV 제노타입에 대하여 현저한 효과를 나타낼 수 있다. 또한, HCV 게놈의 보존 영역에 특이적인 리보자임에 있어서 약물 내성은 일어나지 않을 것 같다. 대조적으로, 바이러스 프로테아제 또는 헬리카제와 같은 효소의 저해를 표적화하는 치료 양식은 이러한 바이러스 엔코딩된 효소에 대한 RNA가 HCV 게놈의 초가변성 부분에 위치하기 때문에 약물 내성 균주에 대하여 선택성을 가져올 것이다.
HCV에 처음 노출된 후에, 환자는 간 효소의 일시적인 상승을 겪으며, 이는 염증 과정이 발생하고 있음을 시사한다[참조: Alter et al., IN: Seef LB, Lewis JH, eds. Current Perspectives in Hepatology. New York: Plenum Medical Book Co; 1989: 83-89]. 상기 간 효소의 상승은 최초 노출 4주 이상 후에 일어날 것이며 2개월까지 지속할 수 있다[참조: Farci et al., New England Journal of Medicine. 1991: 325: 98-104]. 간 효소의 상승 전에, RT-PCR 분석을 사용한 환자 혈청에서 HCV RNA를 검출하는 것이 가능하다[참조: Takahashi et al., American Journal of Gastroenterology. 1993: 88: 2: 240-243]. 상기 질환의 이 단계는 급성기라고 하며, HCV 감염으로 인한 급성 바이러스성 간염을 가진 환자의 75%가 무증상이기 때문에 일반적으로 검출되지 않는다. 이들 환자의 나머지 25%가 황달 또는 간염의 기타 증상을 나타낸다.
급성 HCV 감염은 양성 질환이지만, 급성 HCV 환자의 80%가 혈청 알라닌 아미노트랜스페라제(ALT) 수준의 지속적인 상승 및 순환 HCV RNA의 지속적인 존재로 나타나는 만성 간질환으로 진행한다[참조: Sherock, Lancet 1992; 339: 802]. 10 내지 20여년의 기간 동안 만성 HCV 감염의 자연적인 경과는 환자의 20 내지 50%에서 간경변으로 진행되며[참조: Davis et al., Infectious Agents and Disease 1993; 2: 150: 154], HCV 감염이 간세포성 암종으로 경과하는 것도 상당히 기록된 바 있다[참조: Liang et al., Hepatology. 1993; 18: 1326-1333; Tong et al., Western Journal of Medicine, 1994; Vol. 160, No. 2: 133-138]. 간경변 및/또는 간세포성 암종으로 진행될 가능성이 가장 큰 아집단을 결정하는 연구는 없었으며, 따라서, 모든 환자는 동등한 위험율의 진행성을 가진다.
중요한 것은 간세포성 암종으로 진단된 환자의 생존기간은 최초 진단으로부터 단지 0.9 내지 12.8개월이라는 점이다[참조: Takahashi et al., American Journal of Gastroenterology. 1993: 88: 2: 240-243]. 화학요법제를 사용한 간세포성 암종의 치료는 유효한 것으로 판명되지 않았고 단지 10%의 환자만이 종양의 광범위한 간 침윤에 기인한 수술로부터 이익이 있다[참조: Trinchet et al., Presse Medicine. 1994: 23: 831-833]. 원발성 간세포성 암종의 침윤성이 제공되는 경우, 수술에 대한 유일한 생존가능한 대체 치료는 간이식이다[참조: Pichlmayer et al., Hepatology. 1994: 20: 33S-40S].
간경변으로 진행시, 만성 HCV 감염을 가진 환자는 최초의 원인과 무관하게 임상적인 간경변에 통상적인 임상적 특징을 나타낸다[참조: D'Amico et al., Digestive Diseases and Sciences. 1986; 31: 5: 468-475]. 이러한 임상적 특징은 출혈성 식도 정맥류, 복수, 황달, 및 뇌질환을 포함할 수 있다[참조: Zakim D, Boyer TD. Hepatology a textbook of liver disease. Second Edition Volume 1. 1990 W. B. Saunders Company. Philadelphia]. 간경변의 초기에, 환자는 간 조직 손상이 일어날지라도, 환자의 간은 여전히 혈류중의 대사물질을 해독할 수 있다는 대상적 의미로서 분류된다. 또한, 대상성 간 질환을 가진 대부분의 환자는 무증상이며, 증상을 나타낸 소수는 소화불량 및 허약함과 같은 경증만을 나타낸다. 간경변의 보다 후기에서는, 환자는 혈류중의 대사물질의 해독능이 감소하는 대상적 의미로서 분류되며 이 시기에서는 상기 임상적 특징이 존재한다.
1986년, 다미코(D'Amico) 등은 알코올성 및 바이러스성 간경변을 모두 가진 1155명의 환자에서 임상 증후 및 생존율을 기술하였다[D'Amico supra]. 1155명의 환자 중에서, 70%가 본 시험의 초기에 무증상이었으나, 435명(37%)이 대상성 질환을 가졌다. 나머지 720명(63%)의 환자는 대상부전 질환을 가졌고, 그 78%가 복수, 31%가 황달, 17%가 출혈의 병력을 나타냈고 16%는 뇌질환이었다. 간세포성 암종은 대상 질환을 가진 6명의 환자(.5%) 및 대상부전 질환을 가진 30명의 환자(2.6%)에서 관찰되었다.
6년의 기간에 걸쳐, 대상성 간경변을 가진 환자는 해마다 10%의 비율로 비대상성 질환의 임상적 특징을 나타내었다. 대부분의 경우, 복수는 최초로 발현되는 대상부전이었다. 또한, 초기에 대상 질환을 가진 것으로 나타난 59명의 환자에서 6년의 시험 기간이 끝났을 때 간세포성 암종이 나타났다.
생존과 관련하여, 다미코(D'Amico)의 연구는 본 시험에서 모든 환자에 대한 5년간의 생존율은 단지 40%이었음을 나타냈다. 초기에 대상 간경변을 가진 환자에 대한 6년간의 생존율은 54%이었던 반면, 초기에 대상부전 질환을 가진 것으로 나타난 환자에 대한 6년간의 생존율은 단지 21%였다. 알코올성 간경변을 가진 환자 및 바이러스성 간경변을 가진 환자 사이의 생존율에 유의한 차이는 없었다. 다미코(D'Amico)의 연구에서 환자 사망의 주된 원인은 49%에서 간부전; 22%에서 간세포성 암종; 및 13%에서 출혈이었다(D'Amico supra).
만성 C형 간염은 10 내지 20년의 기간에 걸쳐 간경변, 간부전 및/또는 간세포성 암종을 초래할 수 있는 바이러스(HCV)에 의해 매개된 서서히 진행하는 간의 염증성 질환이다. 미국에서, HCV 감염은 매년 미국에서 새로운 50,000명의 급성 간염 환자의 원인인 것으로 예측된다[참조: NIH Consensus Development Conference Statement on Management of Hepatitis C March 1997]. 미국에서 HCV의 유행은 1.8%로 예측되고 CDC는 만성적으로 감염된 미국인의 수를 약 4.5백만명으로 평가한다. CDC는 또한 해마다 10,000명의 사인은 만성 HCV 감염에 기인하는 것으로 평가한다.
만성 HCV 감염의 치료에 인터페론(IFN-α)을 사용한 많은 대조 임상 시험 결과는 1주 3회 요법은 6개월의 치료가 끝날 때까지 약 50%의 환자(40 내지 70% 범위)에서 혈청 ALT 수치를 감소시킨 것으로 증명되었다[참조: Davis et al., New England Journal of Medicine 1989; 321: 1501-1506; Marcellin et al., Hepatology. 1991; 13: 393-397; Tong et al., Hepatology 1997; 26: 747-754; Tong et al., Hepatology 1997 26(6): 1640-1645]. 그러나, 인터페론 치료를 중지한 후에, 반응한 환자의 약 50%가 재발하였고, 그 결과 혈청 ALT 농도의 정상화로 평가되는 "영구성" 반응율은 약 20 내지 25%였다.
최근 수년간, 분지된 DNA 또는 역전사 효소 중합효소 연쇄 반응(RT-PCR) 분석의 사용하여 HCV RNA의 직접적인 측정이 가능해졌다. 일반적으로, RT-PCR 방법은 보다 감조가 높고 임상적 경과를 보다 정확하게 평가하도록 한다[참조: Tong et al., supra]. 임상적 종말점으로서 HCV RNA 수치의 변화를 사용하여 6개월간의 타입 1 인터페론 요법을 조사한 연구 결과 35% 이하의 환자가 치료가 끝났을 때 HCV RNA가 소실되는 것으로 증명되었다[참조: Marcellin et al., supra]. 그러나, ALT 종말점에서와 같이, 환자의 약 50%가 치료 중지후 6개월에 재발한 결과, 영구의 바이러스학적 반응은 단지 12%에 불과하였다[참조: Marcellin et al., supra]. 48주 요법을 조사한 연구 결과 유지된 바이러스학적 반응은 25% 이하인 것으로 증명되었다(NIH 조사 성명서: 1997). 따라서, 타입 1 인터페론을 사용한 만성 HCV 감염의 치료에 대한 관리 표준은 현재 효능의 1차적 평가로서 HCV RNA의 농도 변화를 사용한 48주간의 치료법이다[참조: Hoofnagle et al., New England Journal of Medicine 1997; 336(5) 347-356].
타입 1 인터페론을 사용한 치료에 기인한 부작용은 4개의 일반적 범주로 분류될 수 있으며, 이는 1. 인플루엔자형 증상; 2. 신경정신증; 3. 실험실검사 이상; 및 4. 기타 혼합을 포함한다[참조: Dusheiko et al., Journal of Viral Hepatitis. 1994: 1: 3-5]. 인플루엔자형 증상의 예로서 피로, 열, 근융통, 권태감, 식욕 상실, 빈맥, 경직, 두통 및 관절통을 포함한다. 인플루엔자형 증상은 일반적으로 일시적이며 투여 첫 4주 후에 감소되는 경항이 있다[참조: Dusheiko et al., supra]. 신경정신증적 부작용은 과민성, 무감동, 기분 변화, 불면증, 인식 변화 및 우울증을 포함한다. 이러한 신경정신증적 부작용중 가장 중요한 것은 우울증이며, 우울증의 병력이 있는 환자는 타입 1 인터페론을 투여받으면 안된다. 실험실검사 이상은 과립구, 혈소판을 포함한 골수 세포의 감소 및 적혈구수의 감소를 포함한다. 혈구수에서 이러한 변화는 어떠한 현저한 임상적 후유증을 거의 일으키지 못한다[참조: Dusheiko et al., supra]. 또한, 트리글리세라이드 농도의 증가 및 혈청 알라닌 및 아스파르테이트 아미노트랜스페라제 농도의 상승이 관찰되었다. 마지막으로, 갑상선 이상이 보고되었다. 이러한 갑상선 이상은 일반적으로 인터페론 요법의 중지후에 역전되며 치료중에 적당한 약물투여로 조절될 수 있다. 기타 혼합적인 부작용은 오심, 설사, 복통 및 요통, 소양증, 탈모, 및 콧물을 포함한다. 일반적으로 대부분의 부작용은 치료 4주 내지 8주 후에 감소된다[참조: Dusheiko et al., supra].
웰치(Welch) 등[참조: Gene Therapy 1996 3(11): 994-1001]은 C형 간염 바이러스를 표적으로 하는 2개의 벡터 발현된 헤어핀 리보자임에 있어서 시험관내 및 생체내 연구를 기술한다.
사카모토(Sakamoto) 등[참조: J. Clinical Investigation 1996 98(12): 2720-2728]은 특정한 벡터 발현된 해머헤드 리보자임에 의한 C형 간염 바이러스 RNA의 세포내 절단 및 바이러스 단백질 번역의 저해를 기술한다.
리이베(Lieber) 등[참조: J. Virology 1996 70(12): 8782-8791]은 아데노바이러스 매개의 특정 해머헤드 리보자임의 발현에 의한 감염된 인간 간세포에서 C형 간염 바이러스 RNA의 제거를 기술한다.
오카와(Ohkawa) 등[참조: 1997, J. Hepatology, 27; 78-84]은 특정한 시험관내 전사된 해머헤드 리보자임을 사용한 HCV RNA의 시험관내 절단 및 바이러스 단백질 번역의 저해를 기술한다.
바아버(Barber) 등[참조: 국제 PCT 공개 제 WO97/32018호]은 특정한 항-C형 간염 바이러스 헤어핀 리보자임을 발현하기 위한 아데노바이러스 벡터의 용도를 기술한다.
케이(Kay) 등[참조: 국제 PCT 공개 제 WO96/18419호]은 항-HCV 해머헤드 리보자임을 발현하기 위한 특정한 재조합 아데노바이러스 벡터를 기술한다.
야마다(Yamada) 등[참조: 일본 특허 출원 제 JP07231784호]은 HCV를 표적으로 하는 특정 폴리-(L)-리신 콘쥬게이션된 해머헤드 리보자임을 기술한다.
드래퍼(Draper)[참조: 미국 특허 제 5,610,054호]는 HCV의 복제를 저해할 수 있는 효소적 핵산 분자를 기술한다.
알트(Alt) 등[참조: Hepatology 1995 22(3): 707-717]은 특정한 안티센스 포스포로티오에이트 올리고데옥시누클레오티드에 의한 C형 간염 바이러스 유전자 발현의 특이적 저해를 기술한다.
발명의 개요
본 발명은 C형 간염 바이러스(HCV)의 RNA종을 절단하도록 되고/거나 HCV에 의해 엔코딩되는 리보자임 또는 효소적 핵산 분자에 관한 것이다. 특히, 출원인은 HCV RNA를 특이적으로 절단할 수 있는 리보자임의 선택 및 기능을 기술한다. 이러한 리보자임은 HCV 감염과 관련된 질환을 치료하기 위하여 사용될 수 있다.
HCV 게놈의 높은 서열 가변성 때문에, 광범위한 치료적 응용을 위한 리보자임의 선택은 HCV 게놈의 보존 영역과 관련될 것이다. 상세하게는, 본 발명은 HCV 게놈의 보존 영역에서 절단시키는 해머헤드 리보자임을 기술한다. HCV 게놈의 보존 영역(5'-비코딩 영역(NCR), 코아 단백질 코딩 영역의 5'-말단, 및 3'-NCR)으로부터 유래된 30개의 해머헤드 리보자임의 목록은 표 Ⅳ에 제시된다. 일반적으로, 본 출원인은 HCV 게놈의 5' 말단에 위치한 부위를 절단시키는 효소적 핵산 분자가 번역을 차단하는 반면, 상기 게놈의 3' 말단에 위치한 부위를 절단시키는 리보자임은 RNA 복제를 차단함을 발견하였다. 약 50개 HCV 분리물이 확인되었고 제노타입 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 5a, 및 6a로부터 이러한 분리물의 서열 정렬이 수행되었다. 본 출원인은 이러한 정렬을 사용하여 제노타입간에 고도로 보존된 영역내의 30개의 해머헤드 리보자임 부위를 확인하였다. 23개의 리보자임 부위는 보존 영역내의 최대의 상동성 영역에서 확인되었다. 따라서, 1개의 리보자임이 HCV의 모든 상이한 분리물을 절단하도록 예정될 수 있다. 본 출원인에 의하면, 다양한HCV 분리물의 보존 영역에 대항하도록 예정된 리보자임은 다양한 환자 집단에서 HCV 복제의 효율적 저해를 가능케 할 것이고 HCV 게놈의 비보존 영역에서 돌연변이에 기인하여 진화한 HCV 유사종에 대한 리보자임의 유효성을 보장할 수 있다.
"저해"는 HCV의 활성 또는 HCV 게놈에 의해 엔코딩된 RNA의 수준이 핵산의 부재하에서 관찰되는 것 미만으로 감소되고, 특히 리보자임을 사용한 저해는 mRNA의 동일한 부위와 결합할 수 있으나 상기 RNA를 절단시킬 수 없는 비활성 RNA 분자의 존재하에서 관찰된 수준 미만인 것을 의미한다.
"효소적 핵산"은 다른 핵산 분자의 부위 특이적 절단 및/또는 연결, 펩티드 및 아미드 결합의 절단, 및 트랜스-스플라이싱을 포함하지만 이에 한정되지 않는 촉매화 반응이 가능한 핵산 분자를 의미한다. 엔도누클레아제 활성을 가진 이러한 분자는 지정된 유전자 표적에 대한 기질 결합 영역에서 상보성을 가질 수 있고, 상기 표적에서 RNA 및 DNA를 특이적을 절단시키는 효소 활성을 가질 수도 있다. 즉, 엔도누클레아제 활성을 가진 핵산 분자는 분자내 또는 분자간에 RNA 또는 DNA를 절단시킬 수 있으므로 표적 RNA 또는 DNA 분자를 불활성화할 수 있다. 이러한 상보성은 효소적 RNA 분자를 표적 RNA 또는 DNA와 충분히 하이브리드화시켜 절단이 일어나도록 하는 기능을 한다. 100% 상보성이 바람직하지만, 50 내지 75%의 상보성도 본 발명에서 유용할 수 있다. 핵산은 염기, 당, 및/또는 인산기에서 변형될 수 있다. 효소적 핵산이라는 용어는 리보자임, 촉매적 RNA, 효소적 RNA, 촉매적 DNA, 촉매적 올리고누클레오티드, 누클레오자임, DNA자임, RNA 효소, 엔도리보누클레아제, 엔도누클레아제, 미니자임, 리드자임, 올리고자임 또는 DNA 효소와 같은 어구와 상호교환적으로 사용된다. 본원에서 기술된 특이적 효소적 핵산 분자는 본 발명에서 제한되지 않으며, 당업자는 본 발명의 효소적 핵산 분자가 하나 이상의 표적 핵산 영역에 상보적인 특이적 기질 결합 부위를 가지며, 분자에 핵산 절단 활성을 부여하는 기질 결합 부위 내 또는 주변의 누클레오티드 서열을 가지는 것이 중요하다는 것을 인지할 것이다.
"효소적 부분" 또는 "촉매적 도메인"은 핵산 기질의 절단에 필수적인 리보자임의 부분/영역을 의미한다(예컨대, 도 1 참조).
"기질 결합 아암(arm)" 또는 "기질 결합 도메인"은 기질의 부분에 상보적인(즉, 이와 염기쌍을 이룰 수 있는) 리보자임의 부분/영역을 의미한다. 일반적으로, 이러한 상보성은 100%이지만, 필요에 따라 보다 적을 수 있다. 예컨대, 14개 중 10개의 염기가 염기쌍을 이룰 수 있다. 이러한 아암(arm)은 일반적으로 도 1 및 3에 도시된다. 즉, 이러한 아암(arm)은 상보적 염기쌍 상호작용을 통하여 리보자임 및 표적 RNA를 짝짓도록 한 리보자임내의 서열을 함유한다. 본 발명의 리보자임은 인접 또는 비인접하고 다양한 길이일 수 있는 결합 아암(arm)을 가질 수 있다. 결합 아암(arm)의 길이는 바람직하게는 4개 누클레오티드 이상이다; 특히 12 내지 100개 누클레오티드; 보다 특별히 14 내지 24개 누클레오티드 길이이다. 2개의 결합 아암(arm)이 선택된 경우, 결합 아암(arm)의 길이가 대칭(즉, 각각의 결합 아암(arm)의 길이가 동일하다; 예컨대 5개 및 5개 누클레오티드, 6개 및 6개 누클레오티드 또는 7개 및 7개 누클레오티드 길이) 또는 비대칭(즉, 결합 아암(arm)의 길이가 상이하다; 예컨대, 6개 및 3개 누클레오티드; 3개 및 6개 누클레오티드 길이; 4개 및 5개 누클레오티드 길이; 4개 및 6개 누클레오티드 길이; 4개 및 7개 누클레오티드 길이; 등)이도록 설계된다.
본원에서 발명의 가장 바람직한 구현예중 하나에서, 효소적 핵산 분자는 해머헤드 또는 헤어핀 모티프로 형성되지만, 간염 d 바이러스, Ⅰ군 인트론, Ⅱ군 인트론 또는 RN아제P RNA(RNA 가이드 서열과 관련) 또는 뉴로스포라(Neyrospora) VS RNA의 모티프로 형성될 수도 있다. 이러한 해머헤드 모티프의 예는 문헌[Dreyfus, supra, Rossi et al., 1992, AIDS Research and Human Retroviruses 8, 183]에 기재되어 있고; 헤어핀 모티프의 예는 문헌[Hampel et al., EP036257, Hempel and Trittz, 1989 Biochemistry 28, 4929, Feldstein et al., 1989, Gene 82, 53, Haseloff and Gerlach, 1989, Gene, 82, 43, and Hempel et al., 1990 Nucleic Scids Res. 18, 299]에 기재되어 있으며; 간염 d 바이러스 모티프는 문헌[Perrotta and Been, 1992 Biochemistry 31, 16]에 기재되어 있고; RN아제P 모티프의 예는 문헌[Guerrier-Takeda et al., 1983 Cell 35, 849; Foster and Altman, 1990, Science 249, 783; Li and Altman, 1996, Nucleic Acids Res. 24, 835]에 기재되어 있으며; 뉴로스포라(Neurospora) VS RNA 리보자임 모티프의 예는 Collins의 문헌[Saville and Collins, 1990 Cell 61, 685-696; Saville and Collins, 1991 Proc. Natl. Acad. Sci. USA 88, 8826-8830; Collins and Olive, 1993 Biochemistry 32, 2795-2799; Guo and Collins, 1995, EMBO. J. 14, 363]에 기재되어 있고; Ⅱ군 인트론의 예는 문헌[Griffin et al., 1995, Chem. Biol. 2, 761; Michels and Pyle, 1995, Biochemistry 34, 2965; Pyle et al., International PCT Publication No. WO96/22689]에 기재되어 있으며; Ⅰ군 인트론의 예는 문헌[Cech et al., U.S. Patent 4,987,071]에 기재되어 있고; DNA자임 모티프의 예는 문헌[Chartrand et al., 1995, Nucleic Acids Research 23, 4092; Santoro et al., 1997, PNAS 94, 4262]에 기재되어 있다. 이러한 특이적 모티프는 본 발명에 한정되지 않으며 당업자는 본 발명의 효소적 핵산 분자가 하나 이상의 표적 유전자 RNA 영역에 상보적인 특이적 기질 결합 부위를 가지며, 상기 분자에 RNA 절단 활성을 부여하는 기질 결합 부위 내 또는 주변의 누클레오티드 서열을 가지는 것이 중요함을 인지할 것이다.
HCV에 대한 "동등한" RNA는 인간, 설치류, 영장류, 토끼 및 돼지를 포함한 다양한 동물에서 HCV 감염과 관련된 천연의 RNA 분자를 포함하는 것을 의미한다. 동등한 RNA 서열은 코딩 영역 뿐만 아니라 5'-비번역 영역, 3'-비번역 영역, 인트론, 인트론-엑손 접합부 등도 포함한다.
"상보성"은 전형적인 왓슨-크릭(Watson-Crick) 또는 기타 비전형적인 유형의 염기쌍 상호작용(예컨대, Hoogsteen형)에 의해 다른 DNA 서열과 수소 결합을 형성할 수 있는 핵산을 의미한다.
한 바람직한 구현예에서, 본 발명은 목적하는 표적의 RNA에 고도의 특이성을 나타내는 일종의 효소적 절단제를 제조하는 방법을 제공한다. 효소적 핵산 분자는 바람직하게는 HCV 단백질을 엔코딩하는 표적 mRNA의 고도의 보존 영역을 표적으로 하여 1개 또는 수개의 효소적 핵산으로 질병의 특이적 치료가 제공될 수 있다. 이러한 효소적 핵산 분자는 필요에 따라 특이적 세포에 외인성으로 전달될 수 있다. 대안적으로, 리보자임은 특이적 세포에 전달되는 DNA/RNA 벡터로부터 발현될 수 있다.
이러한 리보자임은 상기 질환, 및 세포 또는 조직에서 HCV 활성의 수준과 관련된 기타 질환의 예방에 유용하다.
"관련"이라 함은 HCV RNA의 저해 및 이렇게 이루어진 각각의 바이러스 활성 수준의 감소가 질병의 증상을 어느 정도 완화할 것임을 의미한다.
바람직한 구현예에서, 리보자임은 표 Ⅳ 내지 Ⅸ의 표적 서열과 상보적인 결합 아암(arm)을 가진다. 이러한 리보자임의 예는 또한 표 Ⅳ 내지 Ⅸ에 제시된다. 이러한 리보자임의 예는 이들 표에 정의된 서열을 필수적으로 포함한다. 이러한 절단을 방해하지 않은 기타 서열이 존재할 수 있다.
"주성분으로 포함한다"는 것은 활성 리보자임이 예시된 것과 동등한 효소 중심 또는 코아를 함유하고, 결합 아암(arm)이 mRNA와 결합하여 표적 부위에서 절단이 일어나도록 할 수 있다는 것을 의미한다.
따라서, 제 1의 측면에서, 본 발명은 유전자 발현 및/또는 바이러스 복제를 저해하는 리보자임을 특징으로 한다. 이러한 화학적 또는 효소적으로 합성된 RNA 분자는 표적 mRNA의 접근가능한 영역과 결합하는 기질 결합 도메인을 함유한다. 또한, RNA 분자는 RNA의 절단을 촉매하는 도메인을 함유한다. 바람직하게는, RNA 분자는 해머헤드 또는 헤어핀 모티프의 리보자임이다. 결합시에, 리보자임은 표적 mRNA를 절단시켜, 번역 및 단백질 축적을 방지한다. 표적 유전자 발현의 부재시에, HCV 유전자 발현 및/또는 복제는 저해된다.
한 바람직한 구현예에서, 리보자임은 표적 세포에 직접 첨가되거나, 양이온성 지질과 복합체를 형성하고, 리포좀내에 봉입되거나, 기타 다른 방법으로 표적 세포에 전달될 수 있다. 핵산 분자 또는 핵산 복합체는 생체고분자에 혼입 또는 혼입되지 않고 주사, 주입 펌프 또는 스텐트를 통하여 관련 조직으로 국소적으로 투여될 수 있다. 다른 바람직한 구현예에서, 리보자임은 적당한 리포좀 비히클내에서 HCV 활성의 부위(예컨대, 간세포)에 투여된다.
본 발명의 다른 측면에서, 표적 분자를 절단하고 HCV 활성을 저해하는 리보자임은 DNA 또는 RNA 벡터에 삽입된 전사 단위로부터 발현된다. 재조합 벡터는 바람직하게는, DNA 플라스미드 또는 바이러스 벡터이다. 리보자임을 발현하는 바이러스 벡터는 아데노관련 바이러스, 레트로바이러스, 아데노바이러스, 또는 알파바이러스를 기재로 하여 작제될 수 있으나, 이에 한정되지 않는다. 바람직하게는, 리보자임을 발현할 수 있는 재조합 벡터는 상기한 바와 같이 전달되어 표적 세포에 잔존한다. 대안적으로, 바이러스 벡터는 리보자임의 일시적 발현을 위해 사용될 수 있다. 이러한 벡터는 필요에 따라 반복적으로 투여될 수 있다. 일단 발현되면, 리보자임은 표적 mRNA를 절단시킨다. 리보자임 발현 벡터의 전달은, 예컨대 정맥내 투여 또는 근육내 투여, 환자로부터 외식된 표적 세포로 투여후 환자에 재도입하거나 목적하는 표적 세포로 도입하기 위하여 허용되는 기타 수단에 의해 에 의해 전신적으로 이루어질 수 있다[참조: Culture and Stinchcomb, 1996, TIG., 12, 510]. 본 발명의 다른 측면에서, 표적 분자를 절단시키고 바이러스 복제를 억제하는 리보자임은 DNA, RNA, 또는 바이러스 벡터에 삽입된 전사 단위로부터 발현된다. 바람직하게는, 리보자임을 발현할 수 있는 재조합 벡터는 상기한 바와 같이 국소적으로 전달되어 평활근 세포에 일시적으로 잔존한다. 그러나, RNA 발현을 지시하는 다른 포유동물 세포 벡터가 본 목적으로 사용될 수 있다.
"환자"는 외식된 세포의 공여자 또는 피이식자 또는 세포 그자체인 유기체를 의미한다. "환자"는 효소적 핵산 분자가 투여될 수 있는 유기체를 지칭하기도 한다. 바람직하게는, 환자는 포유동물 또는 포유동물 세포이다. 보다 바람직하게는, 환자는 인간 또는 인간 세포이다.
"벡터"는 목적하는 핵산을 전달시키기 위하여 사용되는 핵산 및/또는 바이러스를 기초로 한 기술을 의미한다.
이러한 리보자임은 개별적으로, 또는 다른 약물과 병용 또는 함께 상기 질환을 치료하기 위해 사용될 수 있다. 예컨대, HCV 수준과 관련된 질환을 치료하기 위하여, 당업자에게 자면한 바와 같이, 환자를 치료하거나, 다른 적당한 세포를 치료할수 있다.
본 발명의 다른 특징 및 장점은 바람직한 구현예의 하기 설명, 및 청구범위로부터 자명할 것이다.
바람직한 구현예의 설명
먼저, 도면을 간단하게 설명한다.
도면:
도 1은 몇가지 다른 종류의 효소적 핵산 분자에 대한 2차 구조 모델을 도시한다. 화살표는 절단 부위를 나타내고, 표적 서열을 나타낸다. 점으로 처리된 선은 3차 상호작용을 나타내고, 염기쌍 상호작용을 나타냄을 의미한다. Ⅰ군 인트론: P1 내지 P9은 다양한 스템-루프 구조를 나타낸다[참조: Cech et al., 1994, Nature Struc. Bio., 1, 273]. RN아제P(M1RNA): EGS는 외부 가이드 서열을 나타낸다[Forster et al., 1990, Science, 249, 783; Pace et al., 1990, J. Biol. Chem., 265, 3587]. Ⅱ군 인트론: 5'SS는 5'스플라이스 부위를 의미한다; 3'SS는 3'-스플라이스 부위를 의미한다; IBS는 인트론 결합 부위를 의미한다; EBS는 엑손 결합 부위를 의미한다[참조: Pyle et al., 1994, Biochemistry, 33, 2716]. VS RNA: Ⅰ내지 Ⅵ은 6개 스템-루프 구조를 나타내는 것을 의미한다; 차단된 영역은 3차 상호작용을 나태내는 것을 의미한다[참조: Collins, International PCT Publication No. WO 96/19577]. HDV 리보자임: Ⅰ내지 Ⅳ는 4개의 스템-루프 구조를 나타내는 것을 의미한다[참조: Been et al., US Patent No. 5,625,047] 해머헤드 리보자임: Ⅰ내지 Ⅲ은 3개의 스템-루프 구조를 나타내는 것을 의미한다; 스템 Ⅰ내지 Ⅲ은 임의의 길이일 수 있으며 대칭 또는 비대칭일 수 있다[참조: Usman et al., 1996, Curr. Op. Struct. Bio., 1, 527]. 헤어핀 리보자임: 헬릭스 1, 4 및 5는 임의의 길이일 수 있다; 헬릭스 2는 3 내지 8의 염기쌍 길이이다; Y는 피리미딘이다; 헬릭스 2(H2)는 4개 이상의 염기쌍(즉, n이 1, 2, 3 또는 4)을 가지고, 헬릭스 5는 임의적으로 2개 이상의 염기의 길이를 가질 수 있다(바람직하게는, 3 내지 20개 염기, 즉 m이 1 내지 20이상). 헬릭스 2 및 헬릭스 5는 하나 이상의 염기에 의해 공유적으로 결합될 수 있다(즉, r이 1개 염기). 헬릭스 1, 4 또는 5는 리보자임 구조를 안정화하기 위하여 2개 이상의 염기쌍으로 신장될 수 있고(즉, 4 내지 20개 염기쌍), 바람직하게는 단백질 결합 부위이다. 각각의 경우, 각 N 및 N'는 독립적으로 정상 또는 변형된 염기이고, 각 대시는 가능한 염기쌍 상호작용을 나타낸다. 이러한 누클레오티드는 당, 염기 또는 인산기에서 변형될 수 있다. 완전한 염기쌍 형성은 헬릭스에서 요구되지는 않으나, 바람직한 것이다. 헬릭스 1 및 4는 염기쌍 형성이 유지되는 한 임의의 크기일 수 있다(즉, o 및 p는 각각 독립적으로 0 내지 임의의 수, 예컨대 20이다). 필수적 염기는 구조에서 특이적 염기로 도시되어 있으나, 당업자는 하나 이상이 화학적으로 변형될 수 있거나(비염기성, 염기, 당 및/또는 인산기 변형) 현저한 효과 없이 다른 염기로 대체될 수 있음을 인지할 것이다. 헬릭스 4는 2개의 별개의 분자로부터, 즉 연결 루프없는 분자로부터 형성될 수 있다. 연결 루프가 존재하는 경우, 이는 그 염기, 당 또는 인산기에 변형이 있거나 없는 리보누클레오티드일 수 있다. "q"는 2개 염기이다. 또한, 연길 루프는 비누클레오티드 링커 분자로 대체될 수 있다. H는 염기 A, U, 또는 C를 지칭한다. Y는 피리미딘 염기를 지칭한다. "___"는 공유 결합을 지칭한다[참조: Burke et al., 1996, Nucleic Acids ＆ Mol. Biol., 10, 129; Chowrira et al., US Patent No. 5,631,359].
도 2는 수개의 제노타입으로부터 제조된 전사체를 절단하기 위하여 5' HCV UTR 보존 영역내의 다양한 부위를 표적화하는 리보자임의 능력을 나타내는 그래프이다.
도 3은 세포 배양에서 리보자임 매개된 루시페라제 활성의 감소를 설명하기 위하여 사용된 듀얼 리포터 시스템의 개략도이다.
도 4는 OST-7 세포에서 루시페라제 활성을 감소시키는 리보자임의 능력을 나타내는 그래프이다.
도 5는 비활성 대조와 비교하여, OST-7 세포에서 루시페라제 활성을 감소시키 위하여 표적 부위 HCV.5-313 및 HCV.5-318을 표적화하는 리보자임의 능력을 나타내는 그래프이다.
도 6 a는 HCV-폴리오 바이러스(PV) 복제에 대한 리보자임 처리의 효과를 설명하는 막대 그래프이다. 96-웰 플레이트의 HeLa 세포를 0.1의 다중 감염(MOI)으로 HCV-PV로 감염시켰다. 그 후, 바이러스 접종물을 5% 혈청 및 표시된 바와 같이 양이온성 지질과 복합체형성된 리보자임 또는 대조(200nM)를 함유한 배지로 대체시켰다. 24시간 후에, 세포를 동결/해동에 의해 3회 용해시켰고 바이러스를 플래크 검정에 의해 정량하였다. 스크램블링된 재조(SAC), 결합 대조(BAC), 3P=S 리보자임, 및 4P=S 리보자임이 표시된다. 플래크 형성 단위(pfu)/ml는 삼중 샘플의 평균+표준 편차(S.D.)로서 나타낸다.
도 6b는 야생형 PV 복제에 대한 리보자임 처리의 효과를 설명하는 막대 그래프이다. 96-웰의 HeLa 세포를 30분간 MOI=0.05에서 야생형 PV로 감염시켰다. 모든 리보자임은 (B)중에 4P=S를 함유하였다. 플래크 형성 단위(pfu)/ml는 삼중 샘플의 평균+표준 편차(S.D.)로서 나타낸다.
도 7은 HCV RNA에 대하여 표적화된 다양한 해머헤드 리보자임 작제물의 개략도이다.
도 8은 1회의 HCV-PV 감염에 대한 부위 183 리보자임 처리의 효과를 설명하는 그래프이다. 리보자임 또는 대조로 처리하기 전에 HeLa 세포를 30분간 MOI=5에서 HCV-PV로 감염시켰다. 세포를 6, 7, 또는 8시간후에 용해시켰고 바이러스를 플래크 검정에 의해 정량하였다. 리보자임 결합 아암(arm)/스템 Ⅱ 포맷(7/4, 7/3, 6/4, 6/3) 및 스크램블링된 대조(SAC, 7/4포맷)가 표시된다. 모두 4P=S 안정화를 함유하였다. 결과(pfu/ml)는 2중 샘플의 중간치±범위로 나타낸다.
도 9는 본원에서 기술된 3개의 리보자임 모티프의 2차 구조 모델을 나타낸다.
도 10은 인터페론과 병용한 항-HCV 리보자임의 활성을 나타낸다. 결과(pfu/ml)는 2중 샘플의 중간치±범위로 나타낸다. BAC는 결합 약화된 대조 분자; IF는 인터페론; Rz은 HCV 부위 183을 표적으로 하는 해머헤드 리보자임; pfu는 플래크 형성 단위이다.
리보자임
7개 기본 종류의 천연의 효소적 RNA는 현재 공지되어 있다. 또한, 포스포디에스테르 결합의 절단 및 결합을 촉매할 수 있는 새로운 핵산 촉매를 이끌어내기 위하여 몇가지 시험관내 선택성(진화) 전략[참조: Orgel, 1979, Proc. R. Soc. London, B 205, 435]이 사용되어 왔다[참조: Joyce, 1989, Gene, 82, 83-87; Beaudery et al., 1992, Science 257, 635-641; Joyce, 1992, Scientific American 267, 90-97; Breaker et al., 1994, TIBTECH 12, 268; Bartel et al., 1993, Science 261: 1411-1418; Szostak, 1993, TIBS 17, 89-93; Kumar et al., 1995, FASEB J., 9, 1183; Breaker, 1996, Curr. Op. Biotech., 7, 442; Santoro et al., 1997, Proc. Natl. Acad. Sci., 94, 4262; Tang et al., 1997, RNA 3, 914; Nakamaye ＆ Eckstein, 1994, supra; Long ＆ Uhlenbeck, 1994, supra; Ishizaka et al., 1995, supra; Vaish et al., 1997, Biochemistry 36, 6495; 상기 문헌은 모두 본원에 참고문헌으로 삽입된다]. 각각은 생리적 조건하에서 트랜스에서 포스포디에스테르 결합의 가수분해를 포함한 일련의 반응을 촉매할 수 있다. 표 Ⅰ은 이러한 몇가지 리보자임의 특성을 요약하고 있다. 일반적으로, 효소적 핵산은 먼저 표적 RNA와 결합함으로써 작용한다. 이러한 결합은 표적 RNA를 절단시키는 작용을 하는 분자의 효소적 부분에 매우 근접한 효소적 핵산의 표적 결합 부위를 통하여 일어난다. 따라서, 효소적 핵산은 먼저 표적 RNA를 인식한 후 상보적인 염기쌍 형성을 통하여 표적 RNA와 결합하고 일단 올바른 부위에 결합되면, 효소적으로 작용하여 표적 RNA를 절단한다. 이러한 표적 RNA의 전략적 절단은 그의 엔코딩된 단백질의 직접적인 합성 능력을 파괴할 것이다. 효소적 핵산은 RNA 표적과 결합하여 이를 절단시킨 후에, RNA로부터 유리되어 다른 표적을 찾아 반복적으로 새로운 표적과 결합하고 절단시킬 수 있다.
리보자임의 효소적 성질은 다른 기술에 비하여 장점이 있는데, 이는 치료에 영향을 주는데 필요한 리보자임의 농도가 보다 낮기 때문이다. 이러한 장점은 효소적으로 작용하는 리보자임의 능력을 반영하는 것이다. 따라서, 단일 리보자임 분자는 표적 RNA의 많은 분자를 절단시킬 수 있다. 또한, 리보자임은 고도로 특이적인 저해제이며, 그 저해의 특이성은 표적 RNA와의 결합의 염기쌍 형성 메카니즘 뿐만 아니라 표적 RNA 절단의 메카니즘에 의존한다. 절단 부위 근처에서 단일 미스매치, 또는 염기 치환은 리보자임의 효소적 활성을 완전히 제거하기 위하여 선택될 수 있다.
엔도누클레아제 효소 활성을 가진 핵산 분자는 누클레오티드 염기 서열 특이적 방식으로 다른 별개의 RNA 분자를 반복적으로 절단시킬 수 있다. 이러한 효소적 핵산 분자는 궁극적으로 임의의 RNA 전사체를 표적화하여 시험관내에서 효율적인 절단이 이루어질 수 있다[참조: Zaung et al., 324, Nature 429 1986; Uhlenbeck, 1987 Nature 328, 596; Kim et al., 84 Proc. Natl. Acad. Sci. USA 8788, 1987; Dreyfus, 1988, Einstein Quart. J. Bio. Med., 6, 92; Haeloff and Gerlach, 334 Nature 585, 1988; Cech, 260 JAMA 3030, 1988; and Jefferies et al., 17 Nucleic Acids Research 1371, 1989; Chartrand et al., 1995, Nucleic Acids Research 23, 4092; Santoro et al., 1997, Pnas 94, 4262].
서열 특이성 때문에, 트랜스-절단 리보자임은 인간 질병의 치료제로서 유망하다[참조: Usman ＆ McSwiggen, 1995 Ann. Rep. Med. Chem. 30, 285-294; Christoffersen and Marr, 1995 J. Med. Chem. 38, 2023-2037]. 리보자임은 세포 RNA의 배경 내에서 특이적 RNA 표적을 절단하도록 고안될 수 있다. 이러한 절단 이벤트는 RNA를 비기능적으로 만들고 RNA로부터 단백질 발현을 폐기시킨다. 이러한 방식으로, 질병과 관련된 단백질의 합성은 선택적으로 억제될 수 있다.
HCV RNA에서 명시된 부위를 절단하는 리보자임은 C형 간염 바이러스에 의한 감염의 새로운 치료적 접근법을 나타낸다. 본 출원인은 리보자임이 HCV의 활성을 억제할 수 있고 리보자임의 촉매적 활성은 이들의 억제 효과에 요구됨을 시사한다. 당법자는 HCV RNA를 절단시키는 기타 리보자임이 용이하게 고안될 수 있고 본 발명에 속하는 것이 기술된 실시예로부터 자명하다는 것을 알게 될 것이다.
표적 부위
유용한 리보자임을 위한 표적은 문헌[Draper et al., WO93/23569; Sullivan et al., WO93/23057; Thompson et al., WO94/02595; Draper et al., WO95/04818; McSwiggen et al., UC Patent 5,525,468, 모두 본원에 참고문헌으로 삽입됨]에 기재된 바에 따라 결정될 수 있다. 이들 문헌에 제공된 지침을 반복하기 보다 본원에서는 하기에 당해 분야에 국한되지 않는 이러한 방법의 특정 실시예를 제공한다. 이러한 표적에 대한 리보자임은 상기 출원에 기술된 바에 따라 고안 및 합성되어, 또한 기술된 바에 따라 시험관내 및 생체내에서 시험된다. 이러한 리보자임은 기술된 바에 따라 최적화되고 전달될 수도 있다.
HCV RNA의 서열은 컴퓨터 폴딩 알고리즘을 사용하여 최적의 리보자임 표적 부위에 대하여 스크리닝되었다. 해머헤드 또는 헤어핀 리보자임 절단 부위가 확인되었다. 이들 부위는 표 Ⅳ 내지 Ⅷ에 제시된다(표에서 모든 서열은 5' 에서 3'방향이다). 표에서 누클레오티드 염기 위치는 지정된 유형의 리보자임에 의해 절단되는 부위로서 표시된다. 표에서 누클레오티드 염기 위치는 지정된 유형의 리보자임에 의해 절단되는 부위로서 표시된다.
HCV RNA가 특정 영역에서 고도로 상동적이기 때문에, 몇가지 리보자임 표적 부위도 상동적이다(표 Ⅳ 내지 Ⅷ 참조). 이러한 경우에, 단일 리보자임은 상이한 종류의 HCV RNA를 표적화할 것이다. 수종의 HCV RNA를 표적화하는 1개의 리보자임의 장점은 특히 이러한 RNA 하나 이상이 질병 상태에 기여할 수 있는 경우에 특히 명백하다.
결합될 수 있고, 리보자임 서열이 적당한 2차 구조로 폴딩되는지를 평가하기 위하여 컴퓨터 폴딩에 의해 개별적으로 분석된 해머헤드 또는 헤어핀 리보자임을 고안하였다[참조: Jaeger et al., 1989 Proc. Natl. Sci. USA, 86, 7706]. 결합 아암(arm) 및 촉매 코아 사이에 불리한 분자내 상호작용을 갖는 리보자임은 고려의 대상에 제외하였다. 활성을 최적화하기 위하여 다양한 결합 아암(arm) 길이가 선택될 수 있다. 일반적으로, 각 아암(arm)에 5개 이상의 염기가 표적 RNA와 결합하거나 상호작용할 수 있다. 해머헤드 또는 헤어핀 모티프의 리보자임은 mRNA 메시지에서 다양한 부위에 어닐링되도록 고안되었다. 결합 아암(arm)은 상기 표적 부위 서열에 상보적이다.
리보자임 합성
100개 누클레오티드를 초과하는 길이의 핵산의 합성은 자동화된 방법을 사용하기 어렵고 이러한 분자의 치료적 비용은 고가이다. 본 발명에서, 작은 핵산 모티프(예컨대, 해머헤드 또는 헤어핀 리보자임)가 외인성 전달을 위하여 사용된다. 이러한 분자의 간단한 구조는 mRNA 구조의 표적화된 영역을 공격하는 핵산의 능력을 증가시킨다. 그러나, 이러한 핵산 분자는 진핵성 프로모터로부터 세포내에서 발현될 수도 있다[예컨대, Izant and Weintraub, 1985 Science 229, 345; McGarry and Lindquist, 1986 Proc. Natl. Acad. Sci. USA 83, 399; SullengerScanlon et al., 1991, Proc. Natl. Acad. Sci. USA, 88, 10591-5; Kashani-Sabet et al., 1991 J. Virol, 65, 5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et al., 1990 Science 247, 1222-1225; Thompson et al., 1995 Nucleic Acids Res. 23, 2259]. 당업자는 임의의 핵산이 적당한 DNA/RNA 프로모터로부터 진핵세포에서 발현될 수 있음을 알고 있다. 이러한 핵산의 활성은 리보자임으로부터의 1차 전사로부터의 유리에 의해 증강될 수 있다[참조: Draper et al., PCT WO93/23569, and Sullivan et al., PCT WO94/02595, 양자 모두 본원에서 참고문헌으로 삽입; Ohkawa et al., 1992 Nucleic Acids Symp. Ser. 27, 15-6; Taira et al., Nucleic Acids Res., 19, 5125-30; Venura et al., 1993 Nucleic Acids Res., 21, 3249-55; Chowrira et al., 1994 J. Biol. Chem. 269, 25856].
실시예에서 리보자임은 화학적으로 합성되었다. 사용된 합성 방법은 문헌[참조: Ulseman et al., 1987 J. Am. Chem. Soc. 109, 7845; Scaringe et al., 1990 Nucleic Acids Res., 18, 5433; and Wincott et al., 1995 Nucleic Acids Res., 23, 2677-2684]에 기재된 정상 RNA 합성 방법을 따르며, 5'-말단에서 디메톡시트리틸, 및 3'-말단에서 포스포르아미다이트와 같은 일반적인 핵산 보호 및 커플링기를 사용한다. 소규모의 합성을 알킬실릴 보호된 누클레오티드에 대한 5분 커플링 단계 및 2'-O-메틸화된 누클레오티드에 대하여 2.5분 커플링 단계를 가진 변형된 2.5μmol 규모 프로토콜을 사용하여 394 Applied Biosystems, Inc 합성기로 수행하였다. 표 Ⅱ는 합성 주기에서 사용된 시약의 양 및 접촉 시간을 기재한다. 중합체 결합된 5'-히드록실기에 대하여 6.5배 과량(0.1M 163μL=16.3μmol)의 포스포르아미다이트 및 24배 과량(0.25M 238μL=59.5μmol)의 S-에틸 테트라졸을 각 커플링 주기에서 사용하였다. 394 Applied Biosystems, Inc 합성기상에서 평균 커플링 수율은 트리틸 분획의 비색 정량에 의해 측정하여 97.5 내지 99%이었다. 394 Applied Biosystems, Inc 합성기용 기타 올리고누클레오티드 합성 시약: 탈트리틸화 용액은 메틸렌 클로라이드중의 2% TCA(ABI)이었고; 캡핑은 THF중의 16% N-메틸 이미다졸(ABI) 및 THF중의 10% 아세트산 무수물/10% 2,6-루티딘으로 수행하였으며; 산화 용액은 THF중의 16.9mM I2, 49mM 피리딘, 9% 물(Millipore)이었다. B ＆ J 합성 등급 아세토니트릴을 시약 병으로부터 직접 사용하였다. S-에틸 테트라졸 용액(아세토니트릴중 0.25M)을 American International Chemical, Inc로부터 구입한 고체로부터 제조하였다.
RNA의 탈보호는 하기와 같이 수행하였다. 중합체 결합된, 트리틸 제거된 올리고리보누클레오티드를 합성 컬럼으로부터 4mL 유리 스크류 상부 바이알로 옮겨서 65℃에서 10분간 메틸아민(MA) 용액에 현탁시켰다. -20℃ 이하로 냉각시킨 후에, 상청액을 중합체 지지체로부터 제거하였다. 지지체를 EtOH: MeCN:H2O/3:1:1의 1.0mL로 3회 세척하였고, 보르텍싱시킨 다음 상청액을 최초의 상청액에 첨가하였다. 올리고리보누클레오티드를 함유한 혼합된 상청액을 건조시켜 백색 분말로 하였다.
염기-탈보호된 올리고리보누클레오티드를 무수 TEA·HF/NMP 용액(1.4M HF 농도를 제공하기 위한 1.5mL N-메틸피롤리딘온, TEA 750μL 및 TEA·3HF 1.0mL의 용액 250μL)에 재현탁시켰고 1시간 30분 동안 65℃로 가열하였다. 생성된 완전히 탈보호된 올리고머를 음이온 교환 탈염 이전에 50mM TEAB(9mL)로 담금질하였다.
탈보호된 올리고머의 음이온 교환 탈염을 위하여 TEAB 용액을 50mM TEAB(10mL)로 미리 세척한 Qiagen 500음이온 교환 카트리지(Qiagen, Inc)에 로딩시켰다. 로딩된 카트리지를 50mM TEAB(10mL)로 세척한 후에, RNA를 2M TEAB(10mL)로 용리시켰고 건조시켜 백색 분말로 하였다.
비활성 해머헤드 리보자임을 G5A6의 순서를 바꾸어 치환하고 A14대신에 U로 치환함으로써 합성하였다[Hertel, K. J., et al., 1992, Nucleic Acids Res. 20, 3252로부터 번호매김]. 비활성 리보자임은 G5 대신에 U 그리고 A14 대신에 U로 치환함으로써 합성될 수도 있다. 몇가지 경우에, 기질 결합 아암(arm)의 서열을 무작위화시킨 반면, 전체적인 염기 조성은 유지하였다.
평균적인 단계식 커플링 수율은 98%를 초과하였다[참조: Wincott et al., 1995 Nucleic Acids Res. 23, 2677-2684].
헤어핀 리보자임은 2개 부분으로 합성되며 활성 리보자임을 재작제하기 위하여 어닐링된다[참조: Chowrira and Burke, 1992 Nucleic Acids Res. 20, 2835-2840]. 리보자임은 박테리오파지 T7 RNA 중합효소를 사용하여 DNA 주형으로부터 합성될 수도 있다[참조: Miligan and Uhlenbeck, 1989, Methods Enzymol. 180, 51].
리보자임은 안정성 및/또는 촉매활성을 증강시키기 위하여 누클레아제 내성 기, 예컨대 2'-아미노, 2'-C-알릴, 2'-플루오로, 2'-O-메틸, 2'-H를 사용한 변형, 누클레오티드 염기 변형에 의해 변형된다[참조: Usman and Cedergren, 1992 TIBS 17, 34; Usman et al., 1994 Nucleic Acids Symp. Ser. 31, 163; Burgin et al., 1996 Biochemistry 6, 14090].
리보자임은 일반적인 방법을 사용하는 겔 전기영동에 의해 정제되거나 고압 액체 크로마토그래피(HPLC: Stinchcomb et al., International PCT Publication No. WO95/23225 참조, 전문이 본원에 참고문헌으로 삽입)에 의해 정제되어 물에 재현탁된다.
본 연구에 유용한 화학적으로 합성된 리보자임의 서열은 표 Ⅳ 내지 Ⅸ에 제시된다. 당업자는 이러한 서열이 리보자임의 효소적 부분(결합 아암(arm)을 제외한 모두)이 활성에 영향을 미치도록 변형된 보다 많은 이러한 서열중에서 대표적인 것일 뿐이라는 것을 인지할 것이다. 예컨대, 해머헤드 리보자임의 스템-루프 Ⅱ 서열은 최소 2개의 염기쌍 형성된 스템 구조가 형성되는 경우 임의의 서열을 함유하도록 변화할 수 있다. 유사하게, 헤어핀 리보자임의 스템-루프 Ⅳ 서열은 최소 2개의 염기쌍 형성된 스템 구조가 형성되는 경우 임의의 서열을 함유하도록 변화할 수 있다(치환, 결실, 및/또는 삽입). 바람직하게는, 200개 이하의 염기가 이러한 위치에 삽입된다. 표 Ⅳ 내지 Ⅸ에 기재된 서열은 리보누클레오티드 또는 기타 누클레오티드 또는 비누클레오티드로 형성될 수 있다. 이러한 리보자임(효소적 활성을 가진)은 표에서 상세하게 기술한 리보자임과 동등하다.
리보자임 활성의 최적화
본 발명에서 기술된 리보자임의 촉매적 활성은 문헌[참조: Draper et al., supra]에 의해 기술된 바와 같이 최적화될 수 있다. 상세한 사항은 여기서 반복하지 않겠지만, 리보자임 결합 아암(arm) 길이의 변화, 또는 혈청 리보누클레아제에 의한 분해를 방지하고/거나 효소적 활성을 증강시키는 변형(염기, 당 및/또는 인산기)을 가진 리보자임을 화학적으로 합성하는 것을 포함한다[참조: Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990 Nature 344, 565; Pieken et al., 1991 Science 253, 314; Usman and Cedergren, 1992 Trends in Bioche. Sci. 17, 334; Usman et al., International Publication No. WO 93/15187; and Rossi et al., International Publication No. WO 91/03162; Sproat, US Patent No. 5,334,711; and Burgin et al., supura; 이들 모두는 효소적 RNA 분자의 염기, 인산 및/또는 당 부분에 이루어질 수 있는 다양한 화학적 변형을 기술한다]. 세포에서 그의 효능, 및 RNA 합성 시간을 단축하기 위하여 스템 루프 구조로부터 염기의 제거를 증강하고 화학적 요구조건을 감소시키는 변형이 바람직하다[이들 공보 모두는 본원에서 참고문헌으로 삽입된다].
촉매작용에 현저한 영향없이 그의 누클레아제 안정성 및 효능이 현저히 증강된 효소적 핵산 분자로 도입될 수 있는 당 및 인산 변형을 기술한 당해 분야의 몇가지 예가 있다. 리보자임은 안정성 및/또는 촉매적 활성을 증강시키기 위하여 슬한 증강 누클레아제 내성 기, 예컨대 2'-아미노, 2'-C-알릴, 2'-플루오로, 2'-O-메틸, 2'-H를 사용한 변형, 누클레오티드 염기 변형에 의해 변형된다[참조: Usman and Cedergren, 1992 TIBS 17, 34; Usman et al., 1994 Nucleic Acids Symp. Ser. 31, 163; Burgin et al., 1996 Biochemistry 6, 14090]. 효소적 핵산 분자의 당변형은 당해 분야에서 널리 기술되어 왔다[참조: Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990 Nature 344, 565-568; Pieken et al., Science 1991, 253, 314-317; Usman and Cedergren, 1992 Trends in Bioche. Sci. 1992, 17, 334-339; Usman et al., International Publication No. WO 93/15187; Sproat, US Patent No. 5,334,711; and Beigelman et al., 1995 J. Biol. Chem. 270, 25702; 이들 문헌 모두는 전문이 본원에서 참고문헌으로 삽입된다]. 이러한 간행물은 촉매작용의 저해없이 당, 염기 및/또는 인산기 변형 등의 리보자임내로의 혼입 위치를 결정하기 위한 일반적인 방법 및 전략을 기술하며, 본원에서 참고문헌으로 삽입된다. 이러한 교시의 관점에서, 본 발명의 핵산 촉매를 변형시키기 위하여 유사한 변형이 본원에서 기술된 바와 같이 사용될 수 있다.
효소족 활성을 유지 또는 증강시키는 화학적 변형을 가진 핵산 촉매가 제공된다. 이러한 핵산은 일반적으로 비변형된 핵산보다는 누클레아제에 대해 보다 내성이기도 하다. 따라서, 세포 및/또는 생체내에서 활성은 현저하게 감소되지 않을 수 있다. 본원에서 예시된 바와 같이, 이러한 리보자임은 활성이 전체적으로 10배 감소될지라도 세포 및/또는 생체내에서 유용하다[참조: Burgin et al., 1996, Biochemistr, 35, 14090]. 본원에서 이러한 리보자임은 모든 RNA 리보자임에 대한 효소적 활성을 "유지"하는 것으로 언급된다.
외인성으로 전달되는 치료적 리보자임은 표적 RNA의 번역이 불필요한 단백질의 수준을 감소시키기에 충분히 오랫동안 억제될 때까지 세포내에서 최적의 안정을 가져야 한다. 이러한 기간은 질병 상태에 따라 수시간 내지 수일로 변화한다. 분명히, 리보자임은 유효한 세포내 치료제로서 기능하기 위해서는 누클레아제에 내성이어야 한다. RNA의 화학적 합성에서의 개선[참조: Wincott et al., 1995 Nucleic Acids Res. 23, 2677; 본원에서 참고문헌으로 삽입]이 상기한 바와 같은 누클레아제 안정성을 증가시키기 위하여 누클레오티드 변형을 도입함으로써 리보자임을 변형시키는 가능성을 확대시켰다.
본원에서 사용된 "누클레오티드"는 당해 분야에서 잘 알려진 천연 염기(표준), 및 변형된 염기를 포함하는 것으로 당해 분야에서 인식되는 것이다. 이러한 염기는 일반적으로 당 부분의 1' 위치에 위치한다. 누클레오티드는 일반적으로 염기, 당 및 인산기를 포함한다. 누클레오티드는 당, 인산 및/또는 염기 부분에서 비변형되거나 변형될 수 있다(또한, 누클레오티드 유사체, 변형된 누클레오티드, 비천연 누클레오티드, 비표준형 누클레오티드 등과 상호교환적으로 언급되기도 한다; Usman and McSwiggen, supra; Eckstein et al., International Publication No. WO 92/07065; Usman et al., International Publication No. WO 93/15187; 모두 본원에서 참고문헌으로 삽입). 당해 분야에서 공지된 변형된 핵산 염기의 몇가지 예가 있으며, 최근 Limbach 등[1994, Nucleic Acids Res. 22, 2183]에 의해 요약되었다. 촉매적 활성에 현저한 영향을 미치지 않고 효소적 핵산에 도입될 수 있는 염기 변형의 비제한적인 예 몇가지는 이노신, 퓨린, 피리딘-4-온, 피리딘-2-온, 페닐, 슈도유라실, 2,4,6-트리메톡시 벤젠, 3-메틸 우라실, 디히드로우리딘, 나프틸, 아미노페닐, 5-알킬시티딘(예컨대, 5-메틸시티딘), 5-알킬우리딘(예컨대, 리보티미딘), 5-할로우리딘(에컨대, 5-브로모우리딘) 또는 6-아자피리미딘 또는 6-알킬피리미딘(에컨대,. 6-메틸우리딘) 및 기타를 포함한다[참조: Burgin et al., 1996, Biochemistr, 35, 14090]. 본 측면에서, "변형된 염기"는 1' 위치에서 아데닌, 구아닌, 시토신 및 우라실이외의 누클레오티드 염기 또는 이들의 균등물을 의미한다; 이러한 염기는 효소의 촉매 코아내에서 및/또는 기질 결합 영역에서 사용될 수 있다.
"비염기성(abasic)"은 염기 1개가 부족하거나 1' 위치에서 염기 대신 다른 화학적 기를 가진 당부분을 의미한다.
"비변형된 누클레오시드"는 β-D-리보푸라노오스의 1' 탄소에 결합된 아데닌, 시토신, 구아닌, 우라실 염기중 하나를 의미한다.
"변형된 누클레오시드"는 비변형된 누클레오티드 염기, 당 및/또는 인산의 화학 구조에 변형을 함유한 임의의 누클레오티드 염기를 의미한다.
리보자임의 유용성을 증가시키기 위하여 리보자임 구조에 대한 다양한 변형이 이루어질 수 있다. 이러한 변형은 저장기간, 생체내 반감기, 안정성 및 세포막 침투를 증가시키기 위한 표적 부위로의 이러한 리보자임의 도입의 용이성을 증가시킬 것이고, 표적 세포의 인식 및 결합 능력을 부여할 것이다.
리보자임의 투여
설리반(Sullivan) 등[참조: PCT WO 94/02595]은 효소적 RNA 분자의 전달을 위한 일반적인 방법을 기술한다. 리보자임은 리포좀으로의 캡슐화, 이온토포레시스, 또는 히드로겔, 시클로덱스티린, 생체분해성 나노입자, 및 생체부착성 마이크로스피어와 같은 기타 비히클에 혼입에 의한 방법을 포함하지만 이에 한정되지 않는 당업자에게 공지된 다양한 방법에 의해 세포에 투여될 수 있다. 몇가지 증후에 대하여, 리보자임은 상기 비히클와 함께 또는 없이 세포 또는 조직으로 생체외에서 직접 전달될 수 있다. 대안적으로, RNA/비히클 조합은 직접 주사 또는 카테테르, 주입 펌프 또는 스텐트를 사용하여 국소적으로 전달된다. 다른 전달 경로는 혈관내, 근육내, 피하 또는 관절 주사, 에어로솔 흡입, 경구(정제 또는 필의 형태), 국소, 전신, 안내, 복강내 및/또는 초내 전달을 포함하나, 이에 한정되지 않는다. 리보자임 전달 및 투여에 관한 보다 상세한 설명은 본원에 참고문헌으로 삽입된 문헌[Sullivan et at., supra and Draper et al., PCT WO93/23569]에 제공된다.
본 발명의 분자는 약제로서 사용될 수 있다. 약제는 환자에서 질병 상태의 발생을 예방, 억제하거나 치료(증상을 어느 정도, 바람직하게는 모두 완화)한다.
본 발명의 음으로 하전된 폴리누클레오티드는 약학 조성물을 형성하기 위하여 안정화제, 완충제 등을 함유 또는 함유하지 않는 임의의 표준 수단에 의해 환자에 투여(예컨대, RNA, DNA 또는 단백질) 및 도입될 수 있다. 지질 또는 리포좀 전달 메카니즘을 사용하도자 할 경우에는, 제형화를 위한 표준 프로토콜이 수반될 수 있다. 본 발명의 조성물은 경구용 정제, 캡슐 또는 엘릭시르; 직장 투여용 좌제; 주사 투여용 멸균 용액 및 현탁액 등으로 제형화되어 사용될 수도 있다.
본 발명은 또한 기술된 화합물의 약제학적으로 허용되는 제형을 포함한다. 이러한 제형은 상기 화합물의 염, 예컨대 산부가염, 예컨대 염산, 브롬화수소산, 아세트산, 및 벤젠술폰산의 염을 포함한다.
약학 조성물 또는 제형은, 예컨대 세포 또는 환자, 바람직하게는 사람에게 전신 투여에 적당한 형태의 조성물 또는 제형을 지칭한다. 적당한 형태는 부분적으로는 예컨대 경구, 경피, 또는 주사 투여와 같은 투여 경로에 의존한다. 이러한 형태는 조성물 또는 제형이 표적 세포(즉, 음으로 하전된 중합체가 전달되고자 하는 세포)에 전달하는 것을 방해해서는 안된다. 예컨대, 혈류로 주입된 약학 조성물은 가용성이어야 한다. 다른 인자들이 당해 분야에서 공지되어 있으며, 독성 및 조성물 또는 제형이 효과를 발휘하는 것을 방해하는 형태와 같은 고려사항을 포함한다.
"전신 투여"는 생체내에서 약물이 혈류중에 전신적으로 흡수 또는 축적된 후에 전신을 통하여 분포되는 것을 의미한다. 전신 흡수를 일으키는 투여 경로는 제한이 없이 정맥내, 피하, 복강내, 흡입, 경구, 폐내 및 근육내를 포함한다. 이들 투여 경로 각각은 목적하는 음으로 하전된 중합체, 예컨대 핵산을 접근가능한 질병 조직에 노출시킨다. 약물의 순환계로의 유입속도는 분자량 또는 크기의 함수인 것으로 증명되었다. 본 발명의 화합물을 포함한 리포좀 또는 기타 약물 담체의 사용은 잠재적으로 예컨대 세망내피계(RES)의 조직과 같은 특정 조직 유형으로 약물을 를 국재화시킬 수 있다. 림프구 및 마크로파지와 같은 세포의 표면과 약물의 결합을 촉진할 수 있는 리포좀 제형도 유용하다. 이러한 접근법은 마크로파지 및 림프구의 HCV 감염된 간세포와 같은 비정상 세포의 면역 인식의 특이성을 이용함으로써 표적 세포로 약물의 전달의 증가를 제공할 수 있다.
본 발명은 또한 폴리(에틸렌글리콜)지질을 함유하는 표면 변형된 리포좀(PEG-변형된, 또는 장기간 순환성 리포좀 또는 스텔쓰(stealth) 리포좀)을 포함하는 조성물의 용도를 특징으로 한다. 이러한 제형은 표적 조직에서 약물의 축적을 증가시키는 방법을 제공한다. 이러한 종류의 약물 담체는 단핵성 식세포계(MPS 또는 RES)에 의한 옵소닌화 및 제거를 방해하여, 혈류 순환 시간을 장기화하고 캡슐화된 약물에 대한 조직 노출을 증가시킬 수 있다[참조: Lasic et al., Chem. Rev. 1995, 95, 2601-2627; Ishigawa et al., Chem, Pham. Bull. 1995, 43, 1005-1011]. 이러한 리포좀은 종양에 선택적으로 축적되는 것으로 나타났고, 이는 혈관신생된 표적 조직으로 침윤 및 포획에 의한 것으로 추정된다[참조: Lasic et al., Chem. Rev. 1995, 267, 1275-1276; Oku et al., 1995, Biochem. Biophysis. Acta, 1238, 86-90]. 장기간 순환하는 리포좀은 MPS의 조직에 축적되는 것으로 공지된 종래의 양이온성 리포좀에 비교하여 특히 DNA 및RNA의 약물동력학 및 약물작용학을 증가시킨다[참조: Liu et al., J. Biol. Chem. 1995, 42, 24864-24870; Choi et al., International PCT Publication No. WO96/10390; Holland et al., International PCT Publication No. WO96/10392; 이들 모두는 본원에 참고문헌으로 삽입된다]. 이들 모두는 본원에 참고문헌으로 삽입된다.
또한, 다른 양이온성 분자는 분 발명의 분자를 전달시키기 위하여 이용될 수도 있다. 예컨대, 리보자임은 간으로 안티센스 놀리고누클레오티드의 국재화를 증가시키는 것으로 나타난 글리코실화된 폴리(L-리신)과 콘쥬게이션될 수 있다[참조: Nakazono et al., 1996, Hepatology 23, 1297-1303; Nahato et al., 1997, Biochem Pharm. 53, 887-895]. 글리코실화된 폴리(L-리신)은 효소적 핵산 분자와 공유적으로 결합하거나 정전기적 상호작용을 통하여 효소적 핵산과 결합될 수 있다.
본 발명은 약제학적으로 허용되는 담체 또는 희석제에 목적하는 화합물의 약학적 유효량을 포함하는 저장 또는 투여용으로 제조된 조성물도 포함한다. 치료적 용도로 허용되는 담체 또는 희석제는 약학 분야에서 잘 알려져 있고, 예컨대 본원에 참고문헌으로 삽입된 Remington's Pharmaceutical Sciences, Mack Publishing Co.(A.R. Gennaro edit. 1985)에 기술되어 있다. 예컨대, 보존제, 안정화제, 착색제 및 향료가 제공될 수 있다[Id. 1449]. 이들은 벤조산 나트륨, 소르브산 및 p-히드록시벤조산의 에스테르를 포함한다. 또한, 항산화제 및 현탁화제가 사용될 수 있다.
약학적 유효량은 질병 상태의 발생을 예방 및 억제하거나 치료(증상을 어느 정도, 바람직하게는 모두 완화)하는데 필요한 용량이다. 약학적 유효량은 질병의 유형, 사용된 조성물, 투여 경로, 치료받는 포유동물의 유형, 고려중인 특정 포유동물의 신체적 특성, 병용 약물, 및 의료 분야에서 당업자가 인지하는 기타 인자에 의존한다. 일반적으로, 음으로 하전된 중합체의 효능에 따라 활성 성분 1일 체중 kg당 0.1 내지 100mg의 양이 투여된다.
대안적으로, 본 발명의 효소적 핵산 분자는 진핵성 프로모터로부터 세포내에서 발현될 수 있다[예컨대 Izant and Weintraub, 1985 Science 229, 345; McGarry and Linquist, 1986 Proc. Natl. Acad. Sci. USA 83, 399; Scanlon et al., 1991, Proc. Natl. Acad. Sci. USA 88, 10591-5; Kashani-Sabet et a;., 1992 Antisense Res. Dev., 2, 2-15; Dropulic et al., 1992 J. Virol, 66, 1432-41; Weerasinghe et al., 1991 J. Virol, 65, 5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et al., 1990 Science 247, 1222-1225; Thompson et al., 1995 Nucleic Acids Res.,23, 2259; Good et al., 1997, Gene Therapy, 4, 45; 상기 문헌 모두 전문이 본원에 참고문헌으로 삽입된다]. 당업자는 핵산이 적당한 DNA/RNA 벡터로부터 진핵 세포에서 발현될 수 있음을 알고 있다. 이러한 핵산의 활성은 리보자임에 의한 최초의 전사로부터 유리에 의해 증강될 수 있다[참조: Draper et al., PCT WO93/23569, and Sullivan et al., PCT WO94/02595; Ohkawa et al., 1992 Nucleic Acids Symp. Ser., 27, 15-6; Taira et al., 1991, Nucleic Acids Res., 19, 5125-30; Ventura et al., 1993 Nucleic Acids Res., 21, 3249-55; Chowrira et al., 1994 J. Biol. Chem. 269, 25856; 상기 문헌 모두 전문이 본원에 참고문헌으로 삽입된다].
본 발명의 다른 측면에서, 표적 분자를 절단시키는 효소적 핵산 분자는 DNA 또는 RNA 벡터로 삽입된 전자 단위로부터 발현된다[참조: Couture et al., 1996, TIG., 12, 510]. 재조합 벡터는 바람직하게는 DNA 플라시미드 또는 바이러스 벡터이다. 리보자임 발현 바이러스 벡터는 아데노관련 바이러스, 레트로바이러스, 아데노바이러스, 또는 알파바이러스를 기재로 하여 작제될 수 있으나, 이에 한정되지 않는다. 바람직하게는, 리보자임을 발현할 수 있는 재조합 벡터는 상기한 바와 같이 전달되어 표적 세포에 잔존한다. 대안적으로, 바이러스 벡터는 리보자임의 일시적 발현을 위해 사용될 수 있다. 이러한 벡터는 필요에 따라 반복적으로 투여될 수 있다. 일단 발현되면, 리보자임은 표적 mRNA를 절단시킨다. 활성 리보자임은 예시된 것과 동등한 효소 중심 또는 코아를 함유하고, 결합 아암(arm)이 mRNA와 결합하여 표적 부위에서 절단이 일어나도록 할 수 있다. 이러한 절단을 방해하지 않는 기타 서열이 존재할 수 있다. 리보자임 발현 벡터의 전달은, 예컨대 정맥내 투여 또는 근육내 투여, 환자로부터 외식된 표적 세포로 투여후 환자에 재도입하거나 목적하는 표적 세포로 도입하기 위하여 허용되는 기타 수단에 의해 전신적으로 이루어질 수 있다[참조: Culture and Stinchcomb, 1996, TIG., 12, 510].
본 발명의 다른 측면에서, 본 발명의 하나 이상의 핵산 촉매를 엔코딩하는 핵산 서열을 포함하는 발현 벡터가 개시된다. 본 발명의 핵산 촉매를 엔코딩하는 핵산 서열은 핵산 분자의 발현을 허용하는 방식으로 작동적으로 결합된다.
다른 측면에서, 본 발명은 하기를 포함하는 발현 벡터를 특징으로 한다; a)전사 개시 영역(예컨대, 진핵성 폴 Ⅰ,Ⅱ 또는 Ⅲ 개시 영역); b) 전사 종결 영역(예컨대, 진핵성 폴 Ⅰ,Ⅱ 또는 Ⅲ 종결 영역); c) 본 발명의 하나 이상의 핵산 촉매를 엔코딩하는 유전자; 및 상기 유전자는 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역 및 종결 영역과 작동적으로 결합된다. 벡터는 임의적으로 본 발명의 핵산 촉매를 엔코딩하는 유전자의 5' 측면 또는 3' 측면에 작동적으로 결합된 단백질에 대한 개방 해독 프레임(ORF); 및/또는 인트론(개재 서열)을 포함할 수 있다.
리보자임 서열의 전사는 진핵성 RNA 중합효소 Ⅰ(폴Ⅰ), RNA 중합효소Ⅱ (폴Ⅱ), 또는 RNA 중합효소 Ⅲ(폴Ⅲ)에 대한 프로모터로부터 유도된다. 폴Ⅱ 또는 폴 Ⅲ 프로모터로부터의 전사는 모든 세포에서 높은 수준으로 발현될 것이다; 주어진 세포 유형에서 주어진 폴 프로모터의 수준은 근처에 존재하는 유전자 조절 서열의 성질(증강서열, 침묵서열 등)에 의존할 것이다. 원핵성 RNA 중합효소가 적당한 세포에서 발현되는 경우, 원핵성 RNA 중합효소 프로모터도 사용된다[참조: Elroy-Stein and Moss, 1990 Proc. Natl. Acad. Sci. USA 87, 6743-7; Gao and Huang 1993 Nucleic Acids Res.,21, 2867-72; Lieber et al., 1993 Methods Enzymol., 217, 47-66; Zhou et al., 1990 Mol. Cell. Biol., 10, 4529-37]. 몇몇 연구자들은 이러한 프로모터로부터 발현된 리보자임이 포유동물 세포에서 기능할 수 있는 것으로 설명하였다[예컨대, Kashani-Sabet et al., 1992 Antisense Res. Dev., 2, 3-15; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res 20, 4581-9; Yu et al., 1993 Proc. Natl. Acad. Sci. USA 90, 6340-4; L'Huillier et al., 1992 EMBO J. 11, 4411-8; Lisziewicz et al., 1993 Proc. Natl. Acad. Sci. USA 90, 8000-4; Thompson et al., 1995 Nucleic Acids Res.,23, 2259; Sullenger ＆ Cech, 1993, Science, 262, 1566]. 보다 상세하게는, U6 소핵(sn RNA), 운반 RNA(tRNA) 및 아데노바이러스 VA RNA를 엔코딩하는 유전자로부터 유도된 것과 같은 전사 단위는 세포에서 리보자임과 같은 고농도의 목적하는 RNA 분자를 생성시키는데 유용하다[Thomson et al., supra; Coutuer and Stinchcomb, 1996, supra; Noonberg et al., 1994, Nucleic Acids Res., 22, 2830; Noonberg et al., US Patent No. 5,624,803; Good et al., 1997, Gen Ther. 4, 45; Beigelman et al., International PCT Publication No. WO96/18736; 상기 간행물 모두 본원에서 참고문헌으로 삽입된다]. 상기 리보자임 전사 단위는 플라스미드 DNA 벡터, 바이러스 DNA 벡터(예컨대, 아데노바이러스 또는 아데노관련 바이러스 벡터), 또는 바이러스 RNA 벡터(예컨대, 레트로바이러스 또는 알파바이러스 벡터)를 포함하지만, 이에 한정되지 않는, 포유동물 세포로의 도입을 위한 다양한 벡터로 혼입될 수 있다[참조: Couture and Stinchcomb, 1996, supra].
또다른 측면에서, 본 발명은 핵산 분자의 발현을 허용하는 방식으로, 본 발명의 하나 이상의 촉매적 핵산 분자를 엔코딩하는 핵산 서열을 포함하는 발현 벡터를 특징으로 한다. 발현 벡터는 한 구현예에서 a) 전사 개시 영역; b) 전사 종결 영역; c) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하고, 상기 유전자는 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역 및 종결 영역과 작동적으로 결합하는 것을 특징으로 한다. 다른 바람직한 구현예에서, 발현 벡터는 a) 전사 개시 영역; b) 전사 종결 영역; c) 개방 해독 프레임; d) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하고, 상기 유전자는 개방 해독 프레임의 3' 말단과 작동적으로 결합하고 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역, 개방 해독 프레임 및 종결 영역과 작동적으로 결합하는 것을 특징으로 한다. 또다른 구현예에서, 발현 벡터는 a) 전사 개시 영역; b) 전사 종결 영역; c) 인트론; d) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하고, 상기 유전자는 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역, 인트론 및 종결 영역과 작동적으로 결합하는 것을 특징으로 한다. 다른 구현예에서, 발현 벡터는 a) 전사 개시 영역; b) 전사 종결 영역; c) 인트론; d) 개방 해독 프레임; e) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하고, 상기 유전자는 개방 해독 프레임의 3' 말단과 작동적으로 결합하고 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역, 인트론, 개방 해독 프레임 및 종결 영역과 작동적으로 결합하는 것을 특징으로 한다.
인터페론
타입 Ⅰ 인터페론(IFN)은 25개를 초과하는 IFN-α과[Pesta, 1986, Methods Enzymol. 119, 3-14] 뿐만 아니라 IFN-β, 및 IFN-ω를 포함한 천연의 사이토카인의 일종이다. 동일한 유전자로부터 진화론적으로 유도되었지만[Diaz et al., 1994, Genomics 22, 540-552], 이들 분자의 1차 서열에는 많은 차이점이 있으며, 이는 생물학적 활성에서 진화론적 다양성을 암시한다. 모든 타입 Ⅰ IFN은 IFN의 세포 표면 수용체 결합으로 시작하는 공통적인 페턴의 생물학적 효과를 공유한다[참조: Pfeffer ＆ Strulovici, 1992, Transmembrane secondary messengers for IFN-α/β, In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds 151-160). 결합후에 재너스(Janus) 티로신 키나제 및 STAT 단백질을 포함한 티로신 키나제가 활성화되어, 수개의 IFN-자극된 유전자 산물의 생성을 초래한다[참조: Johnson et al., 1994, Sci. Am. 270, 68-75]. IFN-자극된 유전자 산물은 항바이러스 효과, 항증식 효과, 및 면역조절 효과를 포함한 타입 Ⅰ IFN의 다면성(pleotropic) 생물학적 효과의 원인이 된다[참조: Pestka et al., 1987, Annu. Rev. Biochem. 56, 727]. IFN-자극된 유전자 산물의 예는 2-5-올리고아데닐레이트 합성효소(2-5 OAS), β2-마이크로글로불린, 네오프테린, p68 키나제, 및 Mx 단백질을 포함한다[참조: Chebath ＆ Revel, 1992, The 2-5 A system: 2-5 A synthetase, isospecies and functions. In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds pp 225-236; Samuel 1992, The RNA-dependent P1/eIF-2α protein kinase. In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds pp 237-250; Horisberger, 1992, MX protein: function and Mechanism of Action In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds pp 215-224]. 모든 타입 Ⅰ IFN이 유사한 생물학적 효과를 가지고 있지만, 각 타입 Ⅰ IFN이 모든 활성을 공유하는 것은 아니며, 많은 경우에 활성의 정도는 각 IFN 서브타입에 대하여 실질적으로 상당히 변화한다[참조: Fish et al., 1989, J. Interferon Res. 9, 97-114; Ozes et al., 1992, J. Interferon Res 12, 55-59]. 보다 상세하게는, 상이한 서브타입의 IFN-α의 성질 및 IFN-α의 분자 하이브리드는 약리학적 성질에서 차이를 나타내었다[참조: Rubinstein, 1987, J. Interferon Res. 7, 545-551]. 이러한 약리학적 차이는 3개의 아미노산 잔기 변화에 기인하는 것일 수 있다[Lee et al., 1982, Cancer Res. 42, 1312-1316].
85 내지 166개 아미노산이 공지된 IFN-α에서 보존된다. IFN-α 유사유전자를 제외하면, 약 25개의 공지된 상이한 IFN-α 서브타입이 있다. 이러한 비대립유전자 서브타입을 쌍끼리 비교하면 2 내지 23% 범위의 1차 서열의 차이를 나타낸다. 천연 IFN에 부가하여, 컨센서스 인터페론(CIFN)으로 공지된 천연 재조합 타입 Ⅰ 인터페론은 치료 화합물로서 합성되었다{참조: Tong et al., 1997, Hepatology 26, 747-754].
인터페론은 현재 감염성 질환 및 자가면역 질환 및 암을 포함한 12개 이상의 상이한 적응증에 대하여 사용된다[참조: Borden, 1992, N. Engl. J. Med. 326, 1491-1492]. 자가면역 질환에 대하여, IFN은 류마티스성 관절염, 다발성 경화증, 및 크론병의 치료에 사용되어 왔다. 암 치료에 대하여, IFN은 단독으로 또는 많은 상이한 화합물과 병용하여 사용되어 왔다. IFN이 사용되었던 특정 유형의 암은 편평상피 암종, 흑색종, 부신종, 혈관종, 모양세포성 백혈병, 및 카포시 육종을 포함한다. 감염성 질환의 치료에 있어서, IFN은 마크로파지의 식세포 활성 및 림프구의 세포독성을 증가시키고 세포성 병원체의 전파를 저해한다. IFN이 치료제로서 사용된 특정 적응증은 B형 간염, 인간 유두종바이러스 타입 6 및 11(즉, 생식기 사마귀)[참조: Leventhal et al., 1991, N. Engl. J. Med. 325, 613-617], 만성 과립구성 질환, 및 C형 바이러스성 간염을 포함한다.
만성 HCV 감염의 치료에서 IFN-α를 사용한 많은 대조 임상 시험결과는 주 3회 치료로 6개월의 치료기간이 끝났을 때 환자의 약 50%에서 혈청 ALT 수치가 감소됨이 증명되었다[참조: Davis et al., 1989, The New England Journal of Medicine 321, 1501-1506; Marcellin et al., 1991, Hepatology 13, 393-397; Tong et al., 1997, Hepatology 26 747-754; Tong et al., Hepatology 26 1640-1645]. 그러나, 인터페론 치료의 중지후에, 반응한 환자의 약 50%가 재발한 결과, 혈청 ALT 농도의 정상화로 평가한 "영구" 반응율은 약 20 내지 25%였다. 또한, 임상적 종말점으로서 HCV RNA 수치의 변화를 사용한 타입 1 인터페론 요법을 6개월간 조사한 연구에서 환자의 35% 이하가 치료의 종료시에 HCV RNA가 소실되는 것으로 나타났다[참조: Tong et al., 1997, supra]. 그러나, ALT 종말점에서와 같이, 약 50%의 환자가 치료 중지후 6개월에 재발한 결과 영구적 바이러스학적 반응은 단지 12%에 불과하였다(23). 48주 요법을 시험한 염구에서는 유지된 바이러스학적 반응은 25% 이하인 것으로 나타났다.
IFN과 병용한 리보자임은 HCV 또는 상기한 기타 어느 적응증의 치료 유효성을 개선시킬 가능성이 있다. 감염성 질환, 자가면역질환, 및 암과 같은 질환과 관련된 RNA를 표적화하는 리보자임은 단독으로 또는 증가된 효능을 얻기 위하여 IFN과 같은 기타 요법과 병용하여 사용될 수 있다.
실시예
다음은 본 발명의 효소적 핵산의 선택, 분리, 합성 및 활성을 나타내는 비한정적 실시예이다.
하기 실시예는 HCV RNA를 절단시키는 리보자임의 선택성을 나타낸다. 본원에 기술된 방법은 HCV 복제에 필요한 기타 RNA 표적을 절단시키는 리보자임이 유도되는 설계를 나타낸다.
실시예 1: HCV RNA에서 유효 리보자임의 확인
HCV RNA의 서열을 컴퓨터 폴딩 알고리즘을 사용하여 접근 가능 부위를 스크리닝하였다. 2차 폴딩 구조를 형성하지 않으며 유효 해머헤드 및/또는 헤어핀 리보자임 분해 부위를 함유하지 않는 mRNA 영역을 확인하였다. 이러한 분해 부위의 서열이 표 IV-VIII에 기재되어 있다.
실시예 2: HCV RNA에서 리보자임 절단 부위의 선택
컴퓨터 사용 RNA 폴딩 알고리즘에 의해 예상된 부위가 HCV RNA의 접근 가능 부위에 상응하는 지를 시험하기 위해, 20개의 해머헤드 부위를 분석용으로 선택하였다. 리보자임 표적 부위는 HCV의 게놈 서열(도입 서열 = HPCJTA(Acc#D11168 ＆ D01171))을 분석하고, 폴딩을 기초로 하여 상기 부위를 우선 순위로 하므로써 선택하였다. 해머헤드 리보자임은 각각의 표적물을 결합시킬 수 있도록(도 1 참조) 구성되었으며, 리보자임 서열이 적합한 2차 구조로 폴딩되었는지를 평가하기 위해 컴퓨터 폴딩(Chritoffersen et al., 1994 J. Mol. Struc. Theochem, 311, 273; Jaeger et al., 1989, Proc. Natl. Acad. Sci. USA, 86, 7706)에 의해 개별적으로 분석하였다. 결합 아암과 촉매적 코아간의 바람직하지 않은 분자내 상호작용을 갖는 리보자임은 고려 대상에서 탈락시켰다. 하기 기재되는 바와 같이, 활성을 최적화시키기 위해 결합 아암의 길이를 달리하여 선택할 수 있다. 일반적으로, 각 아암상에 5개 이상의 염기가 표적 RNA 결합할 수 있거나, 다르게는 표적 RNA와 상호작용한다.
리보자임 후보의 선택은 HCV 제노타입 1b에 감염된 환자로부터 유도된 HCV RNA 서열에서 모든 해머헤드 분해 부위를 스캐닝하므로써 개시하였다. 이 서열 분석 결과는 표 III에 기재된다. 표 III으로 알 수 있는 바와 같이, 상기 분석으로 1300개의 해머헤드 리보자임 부위가 확인되었다. 다음으로, HCV 게놈의 보존된 영역에서 절단될 수 있는 해머헤드 리보자임 후보를 확인하기 위해, 제노타입, 1a, 1b, 2a, 2b, 3a, 3b, 4a, 5a 및 6으로부터의 대략 50개의 HCV 단리물의 서열 배열을 완료하였다. 제노타입내에서 부위는 조사된 모든 단리물 간에 가장 큰 서열 동일성을 갖는 영역에 존재하는 것으로 확인되었다. 이러한 분석은 해머헤드 리보자임 후보를 약 23개로 감소시켰다(표 III).
HCV 게놈의 높은 서열 변이성으로 인해, 광범위한 치료 적용을 위한 리보자임의 선택은 HCV 게놈의 보존된 영역을 포함해야 할 것이다. HCV 게놈의 보존된 영역(5'-비코딩 영역(NCR), 5'-코아 단백질 코딩 영역의 말단, 및 3'-NCR)으로부터의 30개 해머헤드 리보자임의 리스트가 표 IV에 기재되어 있다. 일반적으로, HCV 게놈의 5' 말단 영역에 위치한 부위로 표적되는 리보자임은 번역을 차단해야 하고, 게놈의 3' 말단 영역에 위한 리보자임 절단 부위는 RNA 복제를 차단해야 한다.
실시예 3 : 리보자임의 화학적 합성 및 정제
해머헤드 또는 헤어핀 모티프의 리보자임을 RNA 메시지의 다양한 부위에 아닐링하도록 설계하였다. 결합되는 아암(arm)은 상기된 표적 부위 서열에 상보적이다. 그런 다음, 리보자임을 화학적으로 합성하였다. 사용된 합성 방법은 우스만(Usman) 등의 문헌[1987 J. Am. Chem. Soc., 109, 7845], 스카린지(Scaringe) 등의 문헌[1990 Nucleic Acids Res., 18, 5433] 및 윈코트(Wincott) 등의 문헌(상기)에 기술된 RNA 합성 방법을 따랐으며, 5'-말단에서 디메톡시트리틸 및 3'-말단에서 포스포르아미다이트와 같은 보통의 핵산 보호 및 커플링 그룹을 사용하였다. 평균적인 단계식 커플링 수율은 ＞98% 이었다.
G5A6의 순서를 바꾸고 A14대신에 U를 사용함으로써 불활성의 해머헤드 리보자임을 합성하였다(이러한 번호매김은 문헌[Hertel et al., 1992 Nucleic Acids Res., 20, 3252]을 참조). 헤어핀 리보자임을 2개 부분으로 합성하고 아닐링하여 활성 리보자임을 재구성하였다[참고문헌: Chowrira and Burke, 1992 Nucleic Acids Res., 20, 2835-2840]. 박테리오파아지 T7 RNA 폴리머라아제를 사용하여 DNA 템플레이트로부터도 리보자임을 합성하였다[참고문헌: Milligan and Uhlenbeck, 1989, Methods Enzymol. 180, 51]. 누클레아제 저항성 그룹, 예를 들어, 2'-아미노, 2'-C-알릴, 2'-플루오로, 2'-O-메틸, 2'-H에 의한 개질에 의해 안정도를 증대시키기 위해 리보자임을 개질시켰다[참고문헌: Usman and Cedergren, 1992 TIBS 17, 34]. 리보자임을 일반적인 방법을 사용하여 겔 전기영동법에 의해 정제하고 고압 액체 크로마토그래피 (HPLC: 본원에 참고문헌으로 인용된 윈코트 등의 문헌(상기) 참조)에 의해 정제하고 수중에 재현탁시켰다. 본 연구에서 사용된 화학적으로 합성된 리보자임의 서열은 하기 표 4-9에 수록되어 있다.
실시예 4 : 시험관내에서의 HCV RNA 표적의 리보자임 분열
HCV를 대상으로 한 리보자임을 상기한 바와 같이 설계하고 합성하였다. 이들 리보자임을, 예를 들어 다음 과정을 사용하여 시험관내 분열 활성에 대해 시험하였다. HCV내에서의 표적 서열 및 누클레오티드 위치는 표 4에 기재하였다.
분열 반응 : 리보자임 분열 검정을 위해 온길이 또는 부분 온길이, 내부 표지된 표적 RNA를 [α-32P]CTP의 존재하에 시험관내 전사에 의해 제조하고 스핀 크로마토그래피에 의해 G 50 세파덱스 칼럼을 통과시키고 추가의 정제 없이 기질 RNA로서 사용하였다. 대안적으로, 기질을 T4 폴리누클레오티드 키나아제 효소를 사용하여 5'-32P 말단 표지시켰다.
검정은 리보자임 절단 완충액(50 mM Tris-HCl, 37℃에서 pH 7.5, 10 mM MgCl2)중의 미리 데워진 2X 농도의 정제된 리보자임에 의해 수행하였으며 역시 미리 데워진 절단 완충액중에 있는 동일 부피의 기질 RNA(최대 1-5 nM)에 2X 리보자임 혼합물을 첨가함으로써 절단 반응을 개시시켰다. 초기 스크리닝과 같이, 검정을 최종 농도가 40 nM 또는 1 mM인 리보자임, 즉, 리보자임 초과량을 사용하여 37℃에서 1시간 동안 수행하였다. 샘플을 2분 동안 95℃로 가열시키고, 급냉시켜 변성 폴리아크릴아미드 겔에 로딩시킨 후에 동일 부피의 95% 포름아미드, 20 mM EDTA, 0.05% 브로모페놀 블루 및 0.05% 자일렌 시아놀을 첨가함으로써 켄칭시켰다. 리보자임 절단에 의해 생성된 기질 RNA 및 특이적인 RNA 절단 산물을 겔의 자동방사능사진상에 가시화시켰다. 절단 %를 본래 기질 및 절단 산물을 나타내는 밴드들의 포스포 이지저(Phosphor Imager: 등록상표) 정량에 의해 결정하였다.
실시예 5: 환자 혈청에서 HCV RNA를 절단하는 HCV 리보자임의 능력.
HCV RNA에서 리보자임 표적 부위를 핵산가수분해효소 저항성을 부여하는 개질을 사용하여 합성하였다[참조 : Beigelman, 1995, J. Biol. Chem. 270, 25702). 만성 C형 간염 환자로부터의 혈청이 평균 3 x 106copies/ml의 HCV RNA를 보유하고 있다는 것은 널리 알려져 있다. 리보자임 생산 후보물질을 추가로 선택하기 위해, 30 HCV 특이적 리보자임을 인자형 1b HCV 환자의 혈청으로부터 분리된 HCV RNA를 사용하여 HCV RNA 절단 활성에 대해 특징화하였다. HCV 인자형 1b 스크리닝으로부터의 가장 좋은 후보물질이 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 5a 및 6를 포함하는 HCV 인자형의 광위로부터의 분리체에 대해 스크리닝될 것이다. 그러므로, 다양한 범위의 HCV 인자형 및 유사종으로부터의 HCV RNA를 대체로 절단하는 이들의 능력에 기초한 추가 개발을 위해 리보자임 후보물질을 선택하는 것이 가능하다.
실시예 6: 시험관내에서 보존된 HCV RNA 표적 부위의 리보자임 절단
하나의 인자형 내에서 및 다른 인자형들에 걸쳐 고도로 보존되어 있는 게놈의 3 영역이 있다. 이들 보존 서열들은 5' 및 3' 코딩되지 않는 영역(NCR) 뿐만 아니라 코어 단백질 코딩 영역의 5'말단에 나타난다. 이 영역들은 HCV RNA 복제 및 번역을 위해 중요하다고 생각된다. 따라서, 이들 보존된 HCV 게놈 영역들을 표적으로 하는 치료제들은 넓은 범위의 HCV 인자형에 걸쳐 현저한 효과를 가질 수 있다. 유사종의 존재 및 하나 이상의 인자형에 의한 감염에 대한 가능성은 이것이 효과적인 치료의 중요한 특성이 되도록 하였다. 또한, 약물 내성을 유발시키는 것으로 제안되고 있는 돌연변이들은 전형적으로 이렇게 고도로 보존된 영역들내에서 발생하지 않기 때문에 약물 내성이 발생할 것 같지 않다. 다수의 유전자형을 표적화시키고 발달하는 약물 내성의 변화를 감소시키기 위해, 본 출원인은 앞서 언급된 보존 영역내의 동일 영역중에서 분할되는 리보자임을 고안하였다.
서열을 5' NCR, 코어 단백질 코딩 영역의 5' 단부 및 3'NCR에 대해서 정렬시켰다. 5' NCR에 있어서, 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 4f 및 5a를 나타내는 34개의 상이한 단리물을 정렬시켰다. 이러한 정렬은 기준 번호로서 보고된 서열 "HPCK1S1"을 사용하여, 누클레오티드 위치 1에서부터 누클레오티드 위치 350(개시인자 ATG 코돈 아래쪽의 18개의 누클레오티드)까지의 서열을 포함하였다. 코어 단백질 코딩 영역에 있어서, 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 4c, 4f, 5a 및 6a를 나타내는 44개의 상이한 단리물을 정렬시켰다. 이러한 정렬은 개시인자 ATG 코돈 앞쪽의 8개의 누클레오티드로부터 시작하여, 600개의 누클레오티드를 포함하였다. 기준 번호로서, 보고된 서열 "HPCCOPR"을 사용하였으며, 개시인자 코돈 ATG 앞쪽의 8개의 "C" 누클레오티드를 "1"로 지정하였다. 3' NCR 영역에 있어서, 유전자형 1b, 2a, 2b, 3a 및 3b를 나타내는 20개의 상이한 단리물을 정렬시켰다. 이러한 정렬은 게놈의 3' 말단 235개의 누클레오티드중의 서열을 포함하였고, 보고된 서열 "D85516"을 기준 번호로서 사용하였으며, 3' 단부로부터의 235번째 누클레오티드를 "1"로 지정하였다.
각 영역의 정렬의 분석 과정에서, 각각의 서열을 각각의 기준 서열(앞에서 확인됨)과 비교하였으며, 모든 단리물에 대한 동일 영역을 결정하였다. 모든 잠재적인 리보자임 부위를 기준 서열에서 확인하였다. 리보자임 부위를 선택하는데 있어서 가장 우선시되는 것은 부위가 분할 부위와 결합 아암 모두에의 모든 위치에서 정렬된 모든 단리물에 대해 100% 동일성을 가져야 하는 것이다. 이러한 기준을 충족시키는 리보자임 부위를 선택하였다. 또한, 다음과 같은 2가지 특이적인 참작이 이루어졌다: 1) 잠재적인 리보자임 부위가 하나 또는 2개의 누클레오티드 위치를 제외하고 100% 서열 동일성을 갖는 경우에, 그 위치에서의 실제 누클레오티드를 구별된 단리물(들)중에서 조사하였다. "G:U 위블(wobble)" 염기쌍을 허용하도록 디자인된 리보자임이 모든 단리물상에서 작용할 수 있도록 상기 누클레오티드가 존재하는 경우에, 상기 부위를 선택하였다. 2) 잠재적인 리보자임 부위가 하나 또는 두개의 누클레오티드 위치를 제외하고 100% 서열 동일성을 갖는 경우에, 구별되는 누클레오티드(들)을 함유하는 단리물의 유전자형을 조사하였다. 구별되는 단리물의 유전자형이 극히 드물게 보급되는 경우에, 그 부위를 또한 선택하였다.
하기에서 확인되고 참조된 리보자임 부위는 다음과 같이 명명된다: "부위가 존재하는 게놈 영역" 이어서 "절단 부위에 대한 누클레오티드 영역 5'"(앞서 언급된 기준 서열 및 번호에 따름)를 명명하였다. 예를 들어, 5' NCR에서 누클레오티드 위치 67에서의 리보자임 절단 부위를 "5-67"로 지정하였고, 코어 코딩 영역에서 위치 48에서의 리보자임 절단 부위는 "c48"로 지정하였다.
다수의 이러한 리보자임을 세포 배양 실험을 위한 적합한 리보자임 후보물질을 선택하기 위해 시험관내 HCV 절단 검정에서 스크리닝하였다. 스크리닝을 위해 선택된 리보자임은 HCV 번역에 필요한 5' UTR 영역을 표적화하였다. 이들 부위는 8개의 주요 HCV 유전자형 및 18개 서브타입 중에서 모두 보존되며, 상기 기술된 검정에 사용되었던 모든 HCV 단리물에서 고도의 상동성을 갖는다. 4개의 상이한 유전자형(1b, 2a, 4 및 5)의 HCV RNA를 사람 환자로부터 단리시키고, 5' HCV UTR 및 5' 코어 영역을 RT-PCR을 사용하여 증폭시켰다. 5' HCV UTR 영역의 런-오프(run-off) 전사체(750개 이하의 nt 전사체)를 T7 메가스크립트(Magascript) 전사 키트 및 제조업자 프로토콜(Ambion, Inc.)을 사용하여 T7 프로모터가 함유된 RT-PCR 생성물로부터 제조하였다. 혼입되지 않은 누클레오티드를 Bio-Gel P-60 수지(Bio-Rad)상에서 스핀 컬럼 여과에 의해 제거시켰다. 여과된 전사체를 폴리누클레오티드 키나아제(Boehringer/Mannheim)을 사용하여32P로, 효소 제조업자의 프로토콜을 이용하여 150μCi/㎕ 감마-32P-ATP(NEN)로, 5' 말단 표지화시켰다. 키나아제 처리된 전사체를 다시 스핀 정제시켜서, 혼입되지 않은 감마-32P-ATP를 제거하고, 5% 폴리아크릴아미드 겔상에서 정제시켰다.
표 IV로부터의 다양한 부위를 표적화하는 리보자임을 선택하고, RNA 분해의 효율을 시험하기 위해 5' HCV UTR 전사체 서열에 대해 시험하였다. 15개 리보자임을 공지된 바와 같이 합성하였다 (Wincott et al., supra).
검정을 리보자임 분해 완충액(50mM TRIS pH 7.5, 10mM MgCl2, 10 유닛 RNase 억제제(Boehringer/Mannheim), 10mM DTT, 0.5㎍ tRNA)에서 정제된 리보자임의 2X (2μM) 농도를 예비가온시킴으로써 수행하고, 절단 반응을 절단 완충액에서 또한 예비가온시킨 동 부피의 기질 RNA(17.46 pmole 최종 농도)에 2X 리보자임 혼합물을 첨가시킴으로써 개시시켰다. 검정을 1μM 리보자임의 최종 농도, 즉, 과량의 리보자임을 사용하여 37℃에서 24시간 동안 수행하였다. 반응을 동 부피의 95% 포름아미드, 20mM EDTA, 0.05% 브로모페놀 블루 및 0.05% 크실렌 시아놀을 첨가시킴으로써 켄칭(quenching)시킨 후, 샘플을 2분간 95℃로 가열하고, 급랭시키고, 변성 폴리아크릴아미드 겔상으로 로딩시켰다. 리보자임 절단에 의해 생성된 기질 RNA 및 특이적 RNA 분해 생성물을 겔의 자동방사선사진상에서 가시화시켰다. 분해의 퍼센트를 온전한 기질 및 절단 생성물을 나타내는 밴드의 포스포르 이미저(등록상표: Phosphor Imager) 정량에 의해 측정하였다.
겔로부터의 관찰된 절단 단편 크기를 RNA 마커와 비교하여 추정된 단편 크기와 상호관련시켰다. 예측된 절단 단편의 광학 밀도를 포스포르이미지 플레이트로부터 측정하고, 대부분의 절단 생성물을 나타내는 최고 밀도로부터 시험된 HCV 전사체의 각각의 유전자형의 최저치로 순위를 매겼다. 최고 3개의 절단 생성물(시험된 15개 리보자임 중에서)이 5의 순위 값으로 주어지고, 다음 3개의 최고 밀도가 4의 순위 값으로 주어지는 등, 시험된 모든 유전자형에 대해 등급이 주어진다. 각각의 리보자임에 대한 순위 값은 시험된 유전자형 사이에서 평균내어 진다. 개개의 리보자임 순위 값 및 평균값이 도시되고, 비교된다. 결과(도 2)는 다수의 이러한 시험된 리보자임이 유전자형에 관계없이 높은 수준의 절단을 제공할 수 있음을 나타낸다. 특히, 리보자임 표적화 부위 HCV.5-258, HCV.5-294, HCV.5-313(Sakamoto et al., J Clinical Investigation 1996 98(12):2720-2728), 및 HCV.5-318(표 IV)는 RNA 분해의 일관된 패턴을 나타내는 것으로 여겨진다.
실시예 7: OST7 세포내에서 HCV 표적화 리보자임을 사용하는 루시페라제 효소활성의 저해
리보자임이 HCV RNA을 내세포성으로 저해하는 능력을 반딧불 및 레닐라 루시페라제(도 3)을 사용하는 이중 수용기 시스템을 이용하여 시험했다. 5' HCV UTR 영역에 표적화된 리보자임은 절단된 경우에, 전사체가 루시페라제로 번역되지 못하게 하였다. OST-7 세포를 소 태아 혈청 10%, 펜/스트렙 1%, 및 L-글루타민을 함유하는 DMEM 배지내에서 암벽(blacked walled)의 96개의 웰 플레이트 (Packerd)중에 각 웰당 12,5000 세포로 플레이팅시키고, 37℃에서 하룻밤 배양시켰다. 5' HCV UTR을 발현하는 T7 프로모터 및 반딧불 루시페라제(T7C1-341(Wang et al., 1993, J. of Virol. 67, 3338-3344))를 함유하는 플라스미드를 pRLSV40 레닐라 조절 플라스미드(Promega Corporation)과 함께 혼합시킨 후, 리보자임, 및 양이온성 지방을 혼합시켜, 5X 농도의 시약(T7C1-341(4㎍/ml), pRLSV40 레닐라 루시페라제 조절제(6㎍/ml), 리보자임(250nM), 트랜스팩션 시약(28.5㎍/ml)를 제조했다.
상기 복합체 혼합물을 37℃에서 20분동안 배양시켰다. 세포로부터 배지를 제거하고, 옵티-멤(Opti-mem) 배지 120㎕를 웰에 가한 후, 상기 5배 복합체 혼합물 30㎕를 가했다. 상기 옵티-멤 150㎕를 미처리 세포를 지닌 웰에 가했다. 상기 복합체 혼합물을 허성(passive) 용해 완충액 (Promega Corporation)으로 용해시킨 OST-7 세포상에서 4시간 동안 배양시키고, 제조자의 지침(Promega Corporation)에 따라 Dual Luciferase Assay Kit를 사용하여 발광성 신호를 정량했다. 사용된 리보자임 서열을 표 Ⅳ에 나타냈다. 상기 사용된 리보자임은 해머헤드 (hammerhead) 모티프였다. 상기해머헤드 리보자임을 화학적으로 변형시켜 상기 리보자임을 5개의 부위에서 리보스 잔기로 구성되도록 하였다(예를 들어, 도 7 참조); 제 4 위치는 2'-C-알릴 또는 2'-아미노 변형을 가졌으며; 제 7 위치는 2'-아미노 변형 또는 2'-O-메틸 변형을 가졌고; 나머지 누클레오티드 위치는 2'-O--메틸 치환기를 함유하며; 5'-말단의 4개의 누클레오티드는 포스포로티오에이트 치환기를 함유했다. 또한, 리보자임의 3'-말단은 3'-3' 결합된 역위 비염기성 성분(비염기성 데옥시리보스; iH)을 포함한다. 상기 데이터(도 4)는 반딧불 및 레닐라 루시페라제 형광성 사이의 비율을 나타낸다. 5' HCV UTR을 표적화하는 모든 리보자임이 레닐라 루시페라제에 대한 반딧불 루시페라제 시그널을 감소시켰다.
실시예 9: OST-7 세포내에서 불활성 대조와 비교한 루시페라제 활성의 리보자임 매개 저해
상기 이중 수용기 시스템을 사용하여 불활성 대조와 비교한 리보자임에 의해 매개된 루시페라제 활성의 감소 수준을 측정했다. 상기 실시예에 기술한 화학적 조성물을 갖는, HCV 313 및 318(표 Ⅳ) 부위에 대한 리보자임 및 이들의 불활성 대조를 상기와 같이 합성했다. 상기 불활성 대조는 활성 리보자임과 동일한 누클레오티드 염기 조성을 가지나, 상기 누클레오티드 서열은 스크램블링되어 있었다. 조직 배양 및 루시페라제 검정을 위해 사용한 상기 규정을 실시예 8에 제시했으며, 실시예 8은 5배 복합체 혼합물중의 리보자임 농도가 1mM(세포상 최종 농도는 200nM)인 것을 제외하고는 상기 규정과 동일하였다.
그 결과를 도 5에 나타냈다. HCV.5-318을 표적화하는 리보자임은 미처리된 불활성의 대조와 비교하여 반딧불 루시페라제 활성을 현저하게 감소시켰다. 상기 HCV.5-313을 표적화하는 리보자임은 반딧불 루시페라제 활성을 불활성 대조와 비교해 다소 감소시킬 수 있었다.
실시예 10: 리보자임의 바이러스 복제 저해
HCV 감염중에, 바이러스성 RNA는 수개의 과정에서 리보자임 절단에 대한 잠재적 표적으로서 존재한다: 언코팅(uncoating), 번역, RNA 복제 및 패키징. 표적 RNA는 상기 단계들 중 어느 하나의 단계중에서 리보자임 절단에 대해 어느정도 접근할 수 있다. 비록, HCV 5'UTR/루시페라제 수용기 시스템(실시예 9)내에서 HCV 개시 라이보좀 유입 부위(IRES)와 번역 기관과의 결합이 흉내내어지나, 이들 다른 바이러스성 과정은 OST7 시스템에서 나타나지 았았다. 그 결과인 표적 바이러스성 RNA와 결합된 RNA/단백질 복합체는 또한 없었다. 또한, 이들 과정은 추가로 표적 RNA 접근성에 충격을 가할 수 있는 HCV-감염된 세포중에 결합될 수 있었다. 따라서, 본 발명자들은 HCV 5'UTR을 절단시키기 위해 설계한 리보자임이 복제 바이러스 시스템에 영향을 줄 수 있는지 여부를 시험했다.
최근에, 루(Lu)와 위머(Wimmer)가 HCV-폴리오바이러스 키메라를 특성화시켰으며, 여기서 폴리오바이러스 IRES가 HCV로부터의 IRES에 의해 치환되었다(Lu ＆ Wimmer, 1996, Proc. Natl. Acad. Sci. USA. 93, 1412-1417). 폴리오바이러스(PV)는 HCV와 같은 양성 외가닥 RNA 바이러스이나, HCV와는 달리 엔벨로핑되지 않았으며, 세포 배양액 중에서 효과적으로 복제한다. 상기 HCV-PV 키메라는 야생형 PV와 비교하여 안정적이고, 작은 플라크 표현형을 발현한다.
실험을 위해 하기 리보자임을 합성했다(표 Ⅷ): 리보자임 표적화 부위 183(3 5'-말단 포스포로티오에이트 결합), 183 부위에서 스크램블링된 대조, 318 부위(3 5'-말단 포스포로티오에이트 결합)에 대한 리보자임, 리보자임 표적화 부위 183(4 5'-말단 포스포로티오에이트 결합), 불활성 리보자임 부위 183(4 5'-말단 포스포로티오에이트). 헬라 세포를 HCV-PV 키메라를 사용하여 30분동안 감염시킨 직후에 리보자임으로 처리했다. 헬라세포를 U-바닥 96개의 웰 플레이트에 9000-10000 세포/웰의 밀도로 시딩하고, CO25%하에서 24시간 동안 37℃에서 배양시켰다. 리보자임(200nM)의 트랜스팩션을 10X 리보자임(2000nM)과 양이온성 지방(80㎍/㎖)을 DMEM(Gibco BRL)중에서 소 태아 혈청(FBS) 5%와 혼합시킴에 의해 수행했다. 리보자임/지방 복합체를 CO25%하에서 37℃에서 15분동안 배양시켰다. 세포로부터 배지를 제거하고, FBS 혈청 5%와 함께 DMEM(Gibco BRL) 80㎕로 치환시킨 다음, 10X 복합체 20㎕를 가했다.
처리한 세포로부터 HCV-PV의 수율(도 6a)을 플라크 분석으로 정량했다. 상기 플라크 분석은 바이러스 샘플을 혈청 부재의 DMEM(Gibco BRL)중에 희석시키고 100㎕를 6-웰 플레이트내의 헬라 세포 단층(~80% 융합체)에 30분동안 적용시켜 수행했다. 감염시킨 단층을 1.2% 한천(시그마) 3ml와 포개고, CO25%하 37℃에서 배양시켰다. 2-3일 후에, 상기 겹친층을 제거하고, 단층을 크리스탈 바이올렛트 1.2%로 염색시키고, 플라크 형성 단위를 계수했다. 상기 데이터를 도 6a네 나타냈다. 스크램블링된 대조와 비교하여, 부위 183에 대한 리보자임은 80% 초과(P ＜ 0.05)하여 HCV-PV 복제를 저해했다(도 6a의 최초 2개의 막대). 또한, 3 또는 4 포스포로티오에이트 안정화는 바이러스 복제의 저해중에 동등하게 효과적이었다 (P＜0.05 대 대조 각각)(도 6a에서 첫번째와 네번째 막대의 비교). 318 부위에 대한 리보자임은 바이러스 복제에 대해 통계적으로 상당한(P ＜ 0.05) 영향을 가졌다(도 6a에서 제 2와 제 3 막대의 비교).
리보자임 절단 메카니즘이 관찰된 HCV-PV 복제의 저해에 책임이 있음을 확인하기 위해, 결합 아암(arm) 서열을 유지하지만 촉매 코어에 돌연변이를 함유하여 절단 활성을 저하시킨 HCV-PV 감염된 세포를 부위 183에 대한 리보자임으로 처리했다. 이들 세포에서의 바이러스 복제는 스크램블링된 대조 라이보좀으로 처리한 세포와 비교할 경우에, 저해되지 않았으며(도 6a, 제4 및 제 5 막대), 이는 리보자임 절단 활성이 관찰된 HCV-PV 복제의 저해에 필요함을 지시한다. 또한, 리보자임 표적화 부위 183인 HCV 5' UTR은 야생형 PV 복제에 대해서는 아무런 영향이 없었다(도 6b). 이들 데이터는 HCV-PV 복제의 리보자임 매개 저해가 HCV 5' UTR 의존성이며, PV 복제의 일반적인 저해가 아니라는 데 대한 증거를 제공했다.
또한, 부위 183에 대한 리보자임을 헬라 세포에서 단일 감염 사이클중 HCV-PV 복제에 대한 저해력을 시험하기 위해 시험했다(도 8). 부위 183에 대한 리보자임으로 처리한 세포(7/4 포멧)는 스크램블링된 대조(감염 후 8시간째에 80% 초과의 저해, P ＜ 0.001)를 사용하여 처리한 세포보다 현저히 적은 양의 바이러스를 생성시켰다.
실시예 11: 리보자임 길이의 단축
상기 실시예 10에 기술한 모든 리보자임은 각각의 결합 아암에 7개 누클레오티드를 함유하였고, 4개의 염기쌍 스템 Ⅱ 성분(7/4 포멧)을 함유했다. 치료적 리보자임의 약제학적 제조를 위해, 가능하다면 서열의 길이를 최소화시키는 것이 유리하다. 이와 같이, 부위 183에 대한 리보자임을, 리보자임이 각각의 결합 아암에 6개의 누클레오티드를 가지며 스템 Ⅱ 영역이 4개의 염기쌍 길이(6/4 포멧)를 갖도록 외부의 대부분의 누클레오티드를 각각의 결합 아암으로부터 제거하고; 스템 Ⅱ 내의 하나의 염기쌍(2 누클레오티드)을 제거하여 3 염기쌍 스템 Ⅱ(7/3 포멧)를 만들거나; 또는 각각의 결합 아암으로부터 하나의 염기쌍을 제거하여 하나의 염기쌍만큼 스템 Ⅱ를 단축시킴으로써 단축시켰다. (각각의 이들 리보자임을 개략적으로 나타낸 도 7 참조). 7/4, 7/3, 및 6/3 포멧을 사용하여 시험한 모든 포멧에서의 리보자임이 8시간째에 거의 동일한 바이러스 복제의 저해를 가져왔다(모든 포멧에 대한 시간 경로를 거쳐 P ＜ 0.001). 시험한 것 중 가장 짧은 리보자임(6/3 포멧)이 7/4 리보자임(~80% 저해, P ＜ 0.001) 보다 약간 더 효과적이었다(＞ 90% 저해, P ＜ 0.001). 상기 6/3 리보자임은 HCV-PV 키메라중 부위 183에 대한 보다 더 큰 접근 가능성을 가질 수 있다.
실시예 12: HCV 리보자임과 인터페론의 조합 치료
헬라 세포(웰당 10,000 세포수)를 완전 배지(DMEM + 5% FBS)중의 인터페론 알파 12.5 Units/ml를 사용하거나, 완전 배지 단독으로 4시간 동안 예비 처리시킨 후, MOI=0.1 에서 30분동안 감염시켰다. 다음, 상기 바이러스 접종을 제거하고, 리보자임의 결합력을 극심하게 감소시키는 리보자임의 촉매 코어중의 돌연변이를 가지는, HCV 부위 183(Rz)에 대해 표적화시킨 리보자임 또는 결합력 감소된 대조 (BAC) 200nM를 완전배지에서 24시간 동안 양이온성 지방을 사용하여 전달했다. 바이러스 수율을 ml당 평균 플라크 형성 유니트로 (pfu/ml) + SEM으로 나타냈다. 상기 데이터를 도 10에 제시했다.
인터페론(IFN)을 사용한 예비처리가 대조 세포에서 바이러스 수율을 ~10-1가지 감소시켰다(BAC+IFN 대 BAC). 리보자임 처리한 세포는 대조 처리한 세포보다 2x10-1적게 생산하였다(Rz 대 BAc). Rz와 IFN 처리의 조합은 바이러스 수율에서 4x10-2의 상승적 감속를 가져왔다(Rz+IFN 대 BAC). 다른 부가의 효과는 단지 3x10-1감소만을 가져왔다(1x10-1+ 2x10-1).
실시예 13: 다른 리보자임 모티프를 사용한 간염 C 바이러스의 저해
많은 다양한 종류의 리보자임 모티프(RPI 모티프 1-3; 도 9)를 조직배양중 HCV 증식에 대한 저해력에 대해 시험했다. RPI 모티프 Ⅰ의 한 예는 문헌(Kore et al., 1998, Nucleic Acid Research 26, 4116-4120)에 기술되었으며, RPI 모티프 Ⅱ의 일예는 루드빅 및 스프로앳트(Ludwig ＆ Sproat)의 국제 특허출원 PCT 공개공보 WO 98/58058에 기술되었다. RPI 모티프 Ⅲ은 출원인이 최근에 개발한 신규한 리보자임 모티프이며, 상기 모티프의 한 예를 본원에서 시험했다.
OST7 세포를 10% 소 태아 혈청, L-글루타민(2mM), 및 페니실린/스트렙토마이신을 부가시킨 Dulbecco의 변형된 Eagle 배지중에 보유시켰다. 트랜스펙션을 위해, OST 세포를 암벽 96-웰 플레이트(Parkard Instrument)내에 12,500 세포/웰의 밀도로 시딩하고 5% CO2하 37℃에서 24시간 동안 배양시켰다. 표적 수용기 HCVT7C (0.8㎍/ml), 대조 수용기 pRLSV40(1.2㎍/ml), 및 리보자임(50-200nM)의 코트랜스펙션을 하기 방법에 따라 수행했다: HCVT7C(4㎍/ml) 5X 혼합물, pRLSV40(6㎍/ml), 리보자임(250-1000nM), 및 양이온성 지방(28.5㎍/ml)를 OPTI-MEM(GIBCO BRL) 마이너스 혈청 150㎕중에 제조했다. 수용기/리보자임/지방 복합체가 5% CO2하 37℃에서 20분동안 형성되도록 했다. OST7 세포로부터 배지를 제거하고 OPTI-MEM (GIBCO BRL) 마이너스 혈청 120㎕로 치환시킨 후, 즉시 5X 수용기/리보자임/ 지방 복합체 30㎕를 가했다. 세포를 5% CO2하 37℃에서 4시간 동안 배양했다. 실시예 7에따라 루시페라제를 분석했다. 데이터를 대조와 함께 각각의 모티프의 결과를 표 Ⅸ에 요약했다. 모든 리보자임 모티프는 어떠한 HCV에도 표적화시키지 않은 라이보좀(무관한 대조)과 비교하여, HCV 생성량을 감소시킬 수 있었다.
세포 배양 분석
세포 배양물중의 HCV 복제에 대한 보고서가 있으나(하기 참조), 이들 시스템은 복제하기 어렵고 신뢰성이 없는 것으로 밝혀졌다. 따라서, 다른 항-HCV 치료제예컨데, 인터페론 및 리바비린의 개발에서와 같이, 동물연구에서의 안정성을 입증한 후에 본 발명자들은 임상적 적용가능성에 대한 연구를 수행했다.
최근 수개의 보고서는 인간 세포주에서의 HCV의 시험관내 증식을 기술했다. 참고문헌:
HCV의 복제를 T 세포 및 B 세포, 및 인간 간세포로부터 유도한 세포주에서 입증했다. 복제의 입증을 RT-PCR 기초 검정 또는 b-DNA 검정을 사용하여 기록하였다. HCV 에 대한 대부분의 최근의 간행물이 6주이하 동안의 복제를 기록함은 주목할 만하다. HCV로 감염될 수 있는 세포주에 추가하여, 수개의 그룹이 전장 또는 부분적 HCV 게놈의 cDNA 클론을 사용한 세포주의 성공적인 형질전환을 보고했다. 참고문헌:
동물 모델
HCV 시스템에 대해 가장 잘 특성화된 동물 시스템은 침팬치이다. 또한, 침팬치 및 인간에서의 HCV의 감염에 의한 결과인 만성 간염은 매우 유사하다. 비록 임상적으로 관련되지만, 침팬치 모델은 이들 모델의 사용을 어렵게하는 수개의 실제적인 장애를 겪고 있다. 이러한 장애는 하기를 포함한다: 고비용, 오랜 양육기간의 필요성, 및 충분한 양의 동물의 부족. 이러한 요인들 때문에 많은 그룹에서 만성 간염 C 감염의 설치류 모델을 개발하고자 시도하였다. 직접적인 감염이 불가능한 반면에, 수개의 그룹은 일부 또는 전부의 HCV 게놈의 설치류에 대한 안정적인 트랜스팩션 대해 보고했다. 참고문헌:
또한, HCV로 감염된 인간의 간을 면역보충된 마우스로 이식함은 마우스의 혈액에서 HCV RNA의 검출을 연장시키는 결과를 가져왔다.
진단 용도
본 발명의 리보자임은 질환에 걸린 세포내에서 유전적 드리프트 및 돌연변이를 조사하기 위해 또는 세포내의 HCV의 존재를 검출하기 위한 도구로서 사용될 수 있다. 리보자임의 활성과 표적 RNA의 구조와의 밀접한 관련성은 분자내의 임의의 영역에서의 돌연변이를 검출하는 것이 가능하도록 하고, 이는 표적 RNA의 염기 쌍 및 3차원 구조를 변경시켰다. 본원에 기술된 다중 리보자임을 사용함에 의해, 시험관내, 세포 및 조직내에서 RNA의 구조 및 기능에 중요한 누클레오티드의 변화를 맵핑할 수 있다. 리보자임을 사용한 표적 RNAs의 절단은 유전자 발현을 저해하고 질환의 진행중 특정 유전자 생성물의 (주요) 역할을 규정하는데 사용될 수 있다. 이러한 방법으로, 다른 유전자 표적이 질환의 중요한 매개자로서 정의될 수 있다. 이들 실험은 조합 치료(예를 들어, 다른 유전자에 표적화된 다중 리보자임, 공지의 작은 분자 저해제와 결합된 리보자임, 또는 리보자임 및/또는 다른 화학적 또는 생물학적 분자의 조합을 이용한 단속적 치료)를 가능하게 함에 의해 질환의 경과의 보다 더 우수한 치료를 유도할 것이다. 본 발명의 리보자임의 다른 시험관내 용도가 당업계에 잘 알려졌으며, HCV 관련 조건과 연관된 mRNA의 존재의 검출을 포함한다. 이러한 RNA는, 표준 방법을 사용하여 리보자임으로 처리한 후의 절단 생성물의 존재를 결정함에 의해 측정될 수 있다.
특정 실시예에서, 표적 RNA의 단지 야생형 또는 돌연변이형만을 절단할 수 있는 리보자임을 분석에 사용했다. 제 1의 리보자임을 샘플내의 야생형 RNA의 존재를 동정하는데 사용하였고, 제 2의 리보자임을 샘플내의 돌연변이 RNA를 동정하는데 사용했다. 반응 대조로서, 야생형 및 돌연변이 RNA의 합성 기질을 리보자임 양자 모두를 사용하여 절단시킴에 의해 반응에서의 리보자임의 상대적 효율성 및 "비표적화"시킨 RNA 종의 절단의 부재를 입증했다. 합성 기질로부터의 상기 절단 생성물은 샘플에서의 야생형 및 돌연변이 RNAs의 분석을 위한 사이즈 마커를 생성시키는데 기여했다. 이와같이, 각각의 분석은 2개의 리보자임, 두개의 기질, 및 6개의 반응으로 결합되는 하나의 알려지지 않은 샘플을 필요로하였다. 상기 절단 생성물의 존재는 RNase 분석을 사용하여 측정할 수 있으며, 그 결과 각각의 RNA의 전장 및 절단 단편을 폴리아크릴아미드 겔의 하나의 레인중에 분석할 수 있었다. 돌연변이 RNAs의 발현 및 표적 세포내에서의 목적하는 표현형 변환의 잠재적 위험성에 대한 통찰을 얻기 위해 상기 결과를 정량화할 절대적 필요성이 있는 것은 아니다. 그의 단백질 생성물이 표현형(즉, HCV)의 개발중에 연관된 mRNA의 발현은 의험을 설정하는데 적절했다. 필적하는 특이적 활성의 프로우브를 전사체 양자 모두에 대해 사용하며, RNA 수준의 양적인 비교가 적절하여 초기 진단 비용을 절감시킬 것이다. 보다 더 큰 야생형에 대한 돌연변이형의 비율은 RNA 수준을 정량적으로 비교하든지 정성적으로 비교하든지간에 보다 더 높은 위험성과 상호 관련된다.
추가의 용도
본 발명의 서열 특이적 효소성 핵산 분자의 잠재적 유용성은 RNA의 연구에 있어서 DNA 엔도누클레아제 제한효소가 DNA의 연구에서 가지는 것과 많은 점에서 동일하다(Nathans et al., 1975 Ann. Rev. Biochem. 44:273). 예를 들어, 제한 단편의 패턴은 두개의 관련된 RNAs 사이의 서열 관련성을 설정하는데 사용될 수 있으며, 커다란 RNAs는 연구에 보다 더 유용한 크기의 단편으로 절단될 수 있다. 리보자임의 서열 특이성의 조작 가능성은 미지의 서열의 RNAs의 절단에 대해 적합하다.
다른 구체예는 하기 청구범위내에 있다.
표 1
천연 리보자임의 성질
Ⅰ군 인트론
- 크기: ∼150 내지 ＞1000 누클레오티드
- 절단 부위의 5' 직후 표적 서열에 U를 필요로 함.
- 절단 부위의 5' 측면에서 4 내지 6개 누클레오티드를 결합함.
- 반응 메카니즘: 구아노신의 3'-OH를 공격하여 3'-OH 및 5'-구아노신을 가진 절단 산물을 생성함.
- 어떤 경우에는 폴딩 및 활성 구조의 유지를 보조하기 위해 추가적 단백질 보조인자가 요구됨.
- 이 종류의 것으로 300여개가 공지됨. 테트라히메나 터모필라(Tetrahymena thermophila) RNA, 진균성 미토콘드리아, 엽록체, 파지 T4, 청-녹 조류 등에서 개재 서열이 발견됨 .
- 주된 구조적 특징은 주로 계통발생학적 비교, 변이형성, 및 생화학적 연구를 통하여 주로 확립됨[1,2].
- 하나의 리보자임에 대하여 완전한 속도론적 체계가 확립됨[3,4,5,6].
- 리보자임 폴딩 및 기질 도킹의 연구는 진행중임[7,8,9].
- 중요한 나머지의 화학적 변형 조사는 잘 확립되어 있음[10,11].
- 작은(4 내지 6nt) 결합 부위는 이러한 리보자임을 비특이적으로 만들어 표적 RNA를 절단할 수 없으나, 테트라히메나 Ⅰ군 인트론은 손상된 메시지로 새로운 β-갈락토시다제 서열의 결합에 의해 "손상된" β-갈락토시다제 메시지를 회복시키는데 사용되었다[12].
RN아제P RNA(M1 RNA)
- 크기: ∼290 내지 400개 누클레오티드
- 편재하는 리보누클레오티드 효소의 RNA 부분
- tRNA 전구체를 절단하여 성숙한 tRNA를 형성한다[13].
- 반응 메카니즘: M2+-OH에 의한 공격으로 3'-OH 및 5'-인산기를 가진 절단 생성물을 생성가능.
- RN아제P는 원핵생물 및 진핵생물을 통하여 발견된다. RNA 서브단위는 세균, 효모, 설치류, 및 영장류로부터 서열화되었다.
- 치료적 용도로 내인성 RN아제P의 사용은 외부 가이드 서열(EGS)과 표적 RNA의 하이브리드화를 통하여 가능하다[14, 15].
- 중요한 인산기 및 2'OH 접촉은 최근에 확인되었다[16,17]
Ⅱ군 인트론
- 크기: ＞1000누클레오티드
- 표적 RNA를 트랜스 절단하는 것으로 최근 증명되었다[18,19]
- 서열 조건은 완전히 결정되어 있지 않음
- 반응 메카니즘: 내부 아데노신의 2'-OH는 3'-5' 및 2'-5' 분지 지점을 함유한 "래리엇(lariet)" RNA 및 3'-OH를 가진 절단 산물을 생성한다.
- RNA 절단 및 결합 뿐만 아니라 DNA 절단[20,21]에 참여하는 것으로 증명된 유일한 천염 리보자임이다
- 주된 구조적 특징은 계통발생학적 비교를 통하여 주로 확립되어 있다[22]
- 중요한 2'OH 접촉이 초기에 확인됨[23]
- 속도론적 체계는 개발중임.
뉴로스포라(Neurospora) VS RNA
- 크기: ∼144 누클레오티드
- 표적 RNA를 트랜스 절단하는 것으로 최근 증명되었다[18,19]
- 서열 조건은 완전히 결정되어 있지 않음
- 반응 메카니즘: 절단가능 결합에 2'-OH 5' 공격으로 2',3'-사이클릭 인산 및 5'-OH 말단을 가진 절단 산물을 생성한다.
- 결합 부위 및 구조적 조건은 완전히 결정되어 있지 않음.
- 이러한 종류로서 1개만 공지되어 있음. 뉴로스포라(Neurospora) VS RNA에서 발견됨.
해머헤드 리보자임
(참고문헌 참조)
- 크기: ∼ 23 내지 40 누클레오티드
- 절단 부위의 5'직후에 표적 서열 UH를 필요로 한다.
- 절단 부위의 양쪽 측면에서 가변수의 누클레오티드와 결합한다
- 반응 메카니즘: 절단가능 결합에 2'-OH 5' 공격으로 2',3'-사이클릭 인산 및 5'-OH 말단을 가진 절단 산물을 생성한다.
- 이러한 종류로서 14개가 공지됨. 감염원으로서 RNA를 사용하는 많은 식물 병원체(바이러스형)에서 발견.
- 필수 구조적 특징은 2개의 결정 구조를 포함하여 정의되어 있음[26,27]
- 최소의 결합 활성이 증명됨(시험관내 선택을 통한 엔지니어링에 대하여)[28]
- 완전한 속도론적 체계는 2개 이상의 리보자임에 대하여 확립됨[29]
- 중요한 나머지의 화학적 변형 조사는 잘 확립되어 있음[30]
헤어핀 리보자임
- 크기: ∼50 누클레오티드
- 절단 부위 3'직후에 표적 서열 GUC를 필요로 한다.
- 절단 부위의 5' 측면에서 4 내지 6개 누클레오티드 및 가변수를 절단 부위의 3'측면과 결합한다.
- 반응 메카니즘: 절단가능 결합에 2'-OH 5' 공격으로 2',3'-사이클릭 인산 및 5'-OH 말단을 가진 절단 산물을 생성한다.
- 이 종류로서 3개가 공지되어 있음. 감염원으로서 RNA를 사용하는 3개의 식물 병원체(타바코 링스포트 바이러스(tabacco ringspot virus), 아라비스 모자이크 바이러스(arabis mosaic virus) 및 치코리 옐로우 모틀 바이러스(chicory yellow mottle virus)의 새틀라이트 RNA)에서 발견.
- 필수 구조적 특징은 정의되어 있음[31, 32,33,34]
- 결합 활성(절단 활성에 부가하여)은 리보자임이 시험관내 선택을 통한 엔지니어링될 수있도록 한다.
- 완전한 속도론적 체계는 1개의 리보자임에 대하여 확립됨[36]
- 중요한 나머지의 화학적 변형 조사가 시작되었다[37,38]
델타 간염 바이러스(HDV) 리보자임
- 크기: ∼60 누클레오티드
- 표적 RNA의 트랜스 절단이 증명됨[39]
- 절단 부위의 5' 서열이 요구되지 않지만, 결합 부위 및 구조적 조건은 완전히 결정되지 않음[40]
- 반응 메카니즘: 절단가능 결합에 2'-OH 5' 공격으로 2',3'-사이클릭 인산 및 5'-OH 말단을 가진 절단 산물을 생성한다.
- 이 종류로서 2개만이 공지됨, 인간 HDV에서 발견.
- HDV의 순환 형태는 활성이고 증가된 누클레아제 안정성을 나타낸다[41].
참고문헌
Claims (50)
- C형 간염 바이러스(HCV)로부터 유도된 RNA를 특이적으로 절단시키는 효소적 핵산 분자에 있어서, 상기 효소적 핵산 분자가 해머헤드 모티프상태이고, 효소적 핵산 분자의 결합 아암(arm)이 표 Ⅳ 내지 Ⅵ 및 Ⅷ에 정의된 기질 서열중 어느 하나에 상보적인 서열을 포함하는 효소적 핵산 분자.
- C형 간염 바이러스(HCV)로부터 유도된 RNA를 특이적으로 절단시키는 효소적 핵산 분자에 있어서, 상기 효소적 핵산 분자가 헤어핀 모티프상태이고, 효소적 핵산 분자의 결합 아암(arm)이 표 Ⅶ에 정의된 기질 서열중 어느 하나에 상보적인 서열을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항에 있어서, 효소적 핵산 분자가 2개 염기쌍 이상의 길이의 스템 Ⅱ 영역을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항 또는 제 2항에 있어서, 핵산이 RNA에 상보적인 12 내지 100개 염기를 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항 또는 제 2항에 있어서, 핵산이 mRNA에 상보적인 14 내지 24개 염기를 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 2항에 있어서, 효소적 핵산 분자가 3 내지 7개 염기쌍의 길이의 스템 Ⅱ 영역을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 2항에 있어서, 효소적 핵산 분자가 표 Ⅶ에 정의된 리보자임 서열중 너으 하나를 주성분으로 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항에 있어서, 효소적 핵산 분자가 표 Ⅳ 내지 Ⅵ 및 Ⅶ에 정의된 리보자임 서열중 어느 하나를 주성분으로 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항 또는 제 2항의 효소적 핵산 분자를 포함하는 약학 조성물.
- 제 1항 또는 제 2항중 어느 하나의 효소적 핵산 분자를 포함하는 포유동물 세포.
- 제 10항에 있어서, 포유동물 세포가 인간 세포인 것을 특징으로 하는 포유동물 세포.
- 제 1항 또는 제 2항의 효소적 핵산 분자 1개 이상을 엔코딩하는 핵산 서열을 포함하여, 효소적 핵산 분자의 발현을 허용하는 발현 벡터.
- 제 12항의 발현 벡터를 포함하는 포유동물 세포.
- 제 13항에 있어서, 포유동물 세포가 인간 세포인 것을 특징으로 하는 포유동물 세포.
- 치료에 적당한 조건하에서 제 1항 또는 제 2항의 효소적 핵산 분자를 환자에게 투여하는 단계를 포함하는, 간경변, 간 부전 또는 간세포 암종의 치료 방법.
- 치료에 적당한 조건하에서 제 1항 또는 제 2항의 발현 벡터를 환자에게 투여하는 단계를 포함하는, 간경변, 간 부전 및/또는 간세포 암종의 치료 방법.
- 환자의 세포를 제 1항 또는 제 2항의 핵산 분자와 접촉시키는 것을 포함하고, 치료에 적당한 조건하에서 하나 이상의 약물 요법을 사용하는 것을 추가로 포함하는, HCV와 관련된 질환을 가진 환자의 치료 방법.
- 제 1항에 있어서, 핵산이 5개 이상의 리보오스 잔기를 포함하고, 3개 이상의 5' 말단 누클레오티드에서 포스포로티오에이트 결합을 포함하며, 핵산의 4번 위치에서 2'-C-알릴 변형을 포함하고, 10개 이상의 2'-O-메틸 변형을 포함하며, 3'말단 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 18항에 있어서, 핵산 분자가 3'말단에서 3'-3' 결합된 역위된 비염기성 부분을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항에 있어서, 핵산 분자가 5개 이상의 리보오스 잔기를 포함하고, 3개 이상의 5' 말단 누클레오티드에서 포스포로티오에이트 결합을 포함하며, 핵산 분자의 4번 위치 및/또는 7번 위치에서 2'-아미노 변형을 포함하고, 10개 이상의 2'-O-메틸 변형을 포함하며, 3'말단 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항에 있어서, 핵산 분자가 5개 이상의 리보오스 잔기를 포함하고, 3개 이상의 5' 말단 누클레오티드에서 포스포로티오에이트 결합을 포함하며, 핵산 분자의 4번 위치 및/또는 7번 위치에서 비염기성 치환을 포함하고, 10개 이상의 2'-O-메틸 변형을 포함하며, 3'말단 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항에 있어서, 핵산 분자가 5개 이상의 리보오스 잔기를 포함하고, 3개 이상의 5' 말단 누클레오티드에서 포스포로티오에이트 결합을 포함하며, 핵산 분자의 4번 위치 및/또는 7번 위치에서 6-메틸 우리딘 치환을 포함하고, 10개 이상의 2'-O-메틸 변형을 포함하며, 3'말단 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 억제에 적당한 조건하에서 제 1항 또는 제 2항의 효소적 핵산 분자를 포유 동물 세포에 투여하는 단계를 포함하는 포유동물 세포에서 HCV 복제를 억제시키는 방법.
- 제 1항 또는 제 2항의 효소적 핵산 분자를, 별개의 RNA 분자의 절단에 적당한 조건하에서 별개의 RNA 분자와 접촉시키는 것을 포함하는 별개의 RNA 분자를 절단시키는 방법.
- 제 24항에 있어서, 절단이 2가 양이온의 존재하에서 수행되는 것을 특징으로 하는 방법.
- 제 25항에 있어서, 2가 양이온이 Mg2+인 것을 특징으로 하는 방법.
- 제 1항 또는 제 2항에 있어서, 핵산이 화학적으로 합성되는 것을 특징으로 하는 핵산 분자.
- 재 12항에 있어서, 벡터가a) 전사 개시 영역;b) 전사 종결 영역;c) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하며,상기 유전자는 개시 영역 및 종결 영역과 작동적으로 결합되어, 핵산 분자의 발현 및/또는 전달을 허용하는 것을 특징으로 하는 발현 벡터.
- 제 12항에 있어서, 벡터가a) 전사 개시 영역;b) 전사 종결 영역;c) 개방 해독 프레임;d) 상기 개방 해독 프레임의 3'-말단과 작동적으로 연결된, 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하며,상기 유전자는 개시 영역, 개방 해독 프레임 및 종결 영역과 작동적으로 결합되어, 핵산 분자의 발현 및/또는 전달을 허용하는 것을 특징으로 하는 발현 벡터.
- 제 12항에 있어서, 벡터가a) 전사 개시 영역;b) 전사 종결 영역;c) 인트론;d) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하며,상기 유전자는 개시 영역, 인트론 및 종결 영역과 작동적으로 결합되어, 핵산 분자의 발현 및/또는 전달을 허용하는 것을 특징으로 하는 발현 벡터.
- 제 12항에 있어서, 벡터가a) 전사 개시 영역;b) 전사 종결 영역;c) 인트론d) 개방 해독 프레임;e) 상기 개방 해독 프레임의 3'-말단과 작동적으로 연결된, 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하며,상기 유전자는 개시 영역, 인트론, 개방 해독 프레임 및 종결 영역과 작동적으로 결합되어, 핵산 분자의 발현 및/또는 전달을 허용하는 것을 특징으로 하는 발현 벡터.
- C형 간염 바이러스(HCV)로부터 유도된 RNA를 특이적으로 절단시키는 효소적 핵산 분자에 있어서, 효소적 핵산 분자가 DNA 효소인 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항, 제 2항 및 제 32항 중 어느 한 항에 있어서, 효소적 핵산 분자가 하나 이상의 2'-당 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항, 제 2항, 및 제 32항 중 어느 한 항에 있어서, 효소적 핵산이 하나 이상의 핵산 염기 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 1항, 제 2항, 및 제 32항 중 어느 한 항에 있어서, 효소적 핵산 분자이 하나 이상의 포스포로티오에이트 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.
- 제 17항에 있어서, 약물 요법이 타입 Ⅰ 인터페론인 것을 특징으로 하는 방법.
- 제 36항에 있어서, 타입 Ⅰ 인터페론 및 효소적 핵산 분자가 동시에 투여되는 것을 특징으로 하는 방법.
- 제 36항에 있어서, 타입 Ⅰ 인터페론 및 효소적 핵산 분자가 개별적으로 투여되는 것을 특징으로 하는 방법.
- 제 36항에 있어서, 타입 Ⅰ 인터페론이 인터페론 알파인 것을 특징으로 하는 방법.
- 제 36항에 있어서, 타입 Ⅰ 인터페론이 인터페론 베타인 것을 특징으로 하는 방법.
- 제 36항에 있어서, 타입 Ⅰ 인터페론이 인터페론 감마인 것을 특징으로 하는 방법.
- 제 36항에 있어서, 타입 Ⅰ 인터페론이 콘센서스 인터페론인 것을 특징으로 하는 방법.
- 환자의 세포를 제 32항의 핵산 분자와 접촉시키는 것을 포함하고, 치료에 적당한 조건하에서 하나 이상의 약물 요법을 사용하는 것을 추가로 포함하는, HCV와 관련된 질환을 가진 환자의 치료 방법.
- 제 43항에 있어서, 약물 요법이 타입 Ⅰ 인터페론인 것을 특징으로 하는 방법.
- 제 44항에 있어서, 타입 Ⅰ 인터페론 및 효소적 핵산 분자가 동시에 투여되는 것을 특징으로 하는 방법.
- 제 44항에 있어서, 타입 Ⅰ 인터페론 및 효소적 핵산 분자가 개별적으로 투여되는 것을 특징으로 하는 방법.
- 제 44항에 있어서, 타입 Ⅰ 인터페론이 인터페론 알파인 것을 특징으로 하는 방법.
- 제 44항에 있어서, 타입 Ⅰ 인터페론이 인터페론 베타인 것을 특징으로 하는 방법.
- 제 44항에 있어서, 타입 Ⅰ 인터페론이 인터페론 감마인 것을 특징으로 하는 방법.
- 제 44항에 있어서, 타입 Ⅰ 인터페론이 콘센서스 인터페론인 것을 특징으로 하는 방법.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8321798P | 1998-04-27 | 1998-04-27 | |
| US10084298P | 1998-09-18 | 1998-09-18 | |
| US25760899A | 1999-02-25 | 1999-02-25 | |
| US60/083,217 | 1999-03-23 | ||
| US60/100,842 | 1999-03-23 | ||
| US09/274,553 US20020082225A1 (en) | 1999-03-23 | 1999-03-23 | Enzymatic nucleic acid treatment of diseases or conditions related to hepatitis c virus infection |
| US09/274,553 | 1999-03-23 | ||
| US09/257,608 | 1999-03-23 | ||
| PCT/US1999/009027 WO1999055847A2 (en) | 1998-04-27 | 1999-04-26 | Enzymatic nucleic acids molecules which modulate the expressions and/or replication of hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010043111A true KR20010043111A (ko) | 2001-05-25 |
Family
ID=27491784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007011999A Withdrawn KR20010043111A (ko) | 1998-04-27 | 1999-04-26 | Ｃ형 간염 바이러스성 감염과 관련된 질환의 효소적 핵산치료제 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1075508A2 (ko) |
| JP (1) | JP2002512791A (ko) |
| KR (1) | KR20010043111A (ko) |
| CN (1) | CN1312856A (ko) |
| AU (1) | AU757034B2 (ko) |
| CA (1) | CA2326695A1 (ko) |
| ID (1) | ID28053A (ko) |
| WO (1) | WO1999055847A2 (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100490699B1 (ko) * | 2002-10-05 | 2005-05-19 | 제노프라 주식회사 | 씨형 간염 바이러스의 아이알이에스 발현 세포에서만 선택적으로 유전자 활성을 유도하는 트랜스-스플라이싱 리보자임 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745418B2 (en) | 2001-10-12 | 2010-06-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting viral replication |
| CA2480308C (en) * | 2002-03-27 | 2011-10-04 | Aegera Therapeutics Inc. | Antisense iap nucleobase oligomers and uses thereof |
| US7364854B2 (en) * | 2004-01-23 | 2008-04-29 | Biomerieux, Inc | Nucleotide mixture for improved nucleic acid amplification performance |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610054A (en) * | 1992-05-14 | 1997-03-11 | Ribozyme Pharmaceuticals, Inc. | Enzymatic RNA molecule targeted against Hepatitis C virus |
-
1999
- 1999-04-26 ID IDW20002466A patent/ID28053A/id unknown
- 1999-04-26 KR KR1020007011999A patent/KR20010043111A/ko not_active Withdrawn
- 1999-04-26 EP EP99918837A patent/EP1075508A2/en not_active Withdrawn
- 1999-04-26 CN CN99807262A patent/CN1312856A/zh active Pending
- 1999-04-26 CA CA002326695A patent/CA2326695A1/en not_active Abandoned
- 1999-04-26 AU AU36657/99A patent/AU757034B2/en not_active Ceased
- 1999-04-26 JP JP2000545991A patent/JP2002512791A/ja active Pending
- 1999-04-26 WO PCT/US1999/009027 patent/WO1999055847A2/en not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100490699B1 (ko) * | 2002-10-05 | 2005-05-19 | 제노프라 주식회사 | 씨형 간염 바이러스의 아이알이에스 발현 세포에서만 선택적으로 유전자 활성을 유도하는 트랜스-스플라이싱 리보자임 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1312856A (zh) | 2001-09-12 |
| ID28053A (id) | 2001-05-03 |
| CA2326695A1 (en) | 1999-11-04 |
| EP1075508A2 (en) | 2001-02-14 |
| AU3665799A (en) | 1999-11-16 |
| WO1999055847A2 (en) | 1999-11-04 |
| AU757034B2 (en) | 2003-01-30 |
| WO1999055847A3 (en) | 2000-06-15 |
| JP2002512791A (ja) | 2002-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20001027 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |