KR20010006146A - Ｈｉｖ 역전사 효소 억제제로서 유용한 4,4-이치환-3,4-디히드로-2(1ｈ)-퀴나졸리논 - Google Patents

Ｈｉｖ 역전사 효소 억제제로서 유용한 4,4-이치환-3,4-디히드로-2(1ｈ)-퀴나졸리논 Download PDF

Info

Publication number: KR20010006146A
Authority: KR; South Korea
Prior art keywords: dihydro; quinazolinone; trifluoromethyl; substituted; compound
Prior art date: 1997-04-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

KR1019997009225A

Other languages

English (en)

Korean (ko)

Inventor

제프리 더블유. 코베트

수 성 고

Original Assignee

블레어 큐. 퍼거슨

듀폰 파마슈티컬즈 컴퍼니

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-09

Filing date

1998-04-07

Publication date

2001-01-26

1998-04-07 Application filed by 블레어 큐. 퍼거슨, 듀폰 파마슈티컬즈 컴퍼니 filed Critical 블레어 큐. 퍼거슨

2001-01-26 Publication of KR20010006146A publication Critical patent/KR20010006146A/ko

Status Ceased legal-status Critical Current

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

KR1019997009225A 1997-04-09 1998-04-07 Ｈｉｖ 역전사 효소 억제제로서 유용한 4,4-이치환-3,4-디히드로-2(1ｈ)-퀴나졸리논 Ceased KR20010006146A (ko)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US83854097A	1997-04-09	1997-04-09
US7132298P	1998-01-14	1998-01-14
US08/838,540		1998-01-14
US60/071,322		1998-01-14

Publications (1)

Publication Number	Publication Date
KR20010006146A true KR20010006146A (ko)	2001-01-26

Family

ID=26752095

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1019997009225A Ceased KR20010006146A (ko)	1997-04-09	1998-04-07	Ｈｉｖ 역전사 효소 억제제로서 유용한 4,4-이치환-3,4-디히드로-2(1ｈ)-퀴나졸리논

Country Status (19)

Country	Link
EP (1)	EP0973753A2 (fr)
JP (1)	JP2002504095A (fr)
KR (1)	KR20010006146A (fr)
CN (1)	CN1252063A (fr)
AR (1)	AR012340A1 (fr)
AU (1)	AU734928B2 (fr)
BR (1)	BR9808513A (fr)
CA (1)	CA2284996A1 (fr)
EA (1)	EA001991B1 (fr)
EE (1)	EE9900452A (fr)
HR (1)	HRP980143A2 (fr)
HU (1)	HUP0001446A3 (fr)
IL (1)	IL132188A0 (fr)
NO (1)	NO314936B1 (fr)
NZ (1)	NZ500592A (fr)
PL (1)	PL336305A1 (fr)
SK (1)	SK137899A3 (fr)
TW (1)	TW587078B (fr)
WO (1)	WO1998045276A2 (fr)

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US7547287B2 (en)	2002-04-19	2009-06-16	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
EP1575583A1 (fr) *	2002-12-16	2005-09-21	Boehringer Ingelheim Pharmaceuticals Inc.	Traitement d'une infection par le vih par administration combinee de tipranavir et de capravirine
US8574895B2 (en)	2002-12-30	2013-11-05	Sanofi-Aventis Deutschland Gmbh	Method and apparatus using optical techniques to measure analyte levels
WO2006001797A1 (fr)	2004-06-14	2006-01-05	Pelikan Technologies, Inc.	Element penetrant peu douloureux
EP1671096A4 (fr)	2003-09-29	2009-09-16	Pelikan Technologies Inc	Procede et appareil permettant d'obtenir un dispositif de capture d'echantillons ameliore
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EP1706026B1 (fr)	2003-12-31	2017-03-01	Sanofi-Aventis Deutschland GmbH	Procédé et appareil permettant d'améliorer le flux fluidique et le prélèvement d'échantillons
EP1751546A2 (fr)	2004-05-20	2007-02-14	Albatros Technologies GmbH & Co. KG	Hydrogel imprimable pour biocapteurs
EP1765194A4 (fr)	2004-06-03	2010-09-29	Pelikan Technologies Inc	Procede et appareil pour la fabrication d'un dispositif d'echantillonnage de liquides
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WO2009126900A1 (fr)	2008-04-11	2009-10-15	Pelikan Technologies, Inc.	Procédé et appareil pour dispositif de détection d’analyte
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US8965476B2 (en)	2010-04-16	2015-02-24	Sanofi-Aventis Deutschland Gmbh	Tissue penetration device
CN102060786A (zh) *	2011-01-20	2011-05-18	天津大学	4-(取代-1,3-二炔基)-4-(三氟甲基)-3,4-二氢取代喹唑啉-2-酮类化合物及其制备方法和应用
MX343037B (es) *	2011-04-06	2016-10-20	Biovaxim Ltd	Composiciones farmaceuticas para evitar y/o tratar una enfermedad de vih en humanos.
CN104321325B (zh)	2012-05-24	2016-11-16	诺华股份有限公司	吡咯并吡咯烷酮化合物
US9403827B2 (en)	2013-01-22	2016-08-02	Novartis Ag	Substituted purinone compounds
US9556180B2 (en)	2013-01-22	2017-01-31	Novartis Ag	Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
EA029312B1 (ru)	2013-05-27	2018-03-30	Новартис Аг	Производные имидазопирролидинона и их применение при лечении заболеваний
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MX2015016421A (es)	2013-05-28	2016-03-03	Novartis Ag	Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades.
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1998
- 1998-03-19 HR HR60/071,322A patent/HRP980143A2/hr not_active Application Discontinuation
- 1998-04-06 AR ARP980101558A patent/AR012340A1/es not_active Application Discontinuation
- 1998-04-07 PL PL98336305A patent/PL336305A1/xx unknown
- 1998-04-07 JP JP54297198A patent/JP2002504095A/ja active Pending
- 1998-04-07 CA CA002284996A patent/CA2284996A1/fr not_active Abandoned
- 1998-04-07 EP EP98913401A patent/EP0973753A2/fr not_active Withdrawn
- 1998-04-07 KR KR1019997009225A patent/KR20010006146A/ko not_active Ceased
- 1998-04-07 WO PCT/US1998/006733 patent/WO1998045276A2/fr not_active Ceased
- 1998-04-07 CN CN98803974A patent/CN1252063A/zh active Pending
- 1998-04-07 IL IL13218898A patent/IL132188A0/xx unknown
- 1998-04-07 AU AU67960/98A patent/AU734928B2/en not_active Ceased
- 1998-04-07 SK SK1378-99A patent/SK137899A3/sk unknown
- 1998-04-07 EA EA199900907A patent/EA001991B1/ru not_active IP Right Cessation
- 1998-04-07 EE EEP199900452A patent/EE9900452A/xx unknown
- 1998-04-07 NZ NZ500592A patent/NZ500592A/en unknown
- 1998-04-07 BR BR9808513-1A patent/BR9808513A/pt not_active IP Right Cessation
- 1998-04-07 HU HU0001446A patent/HUP0001446A3/hu unknown
- 1998-04-15 TW TW087105365A patent/TW587078B/zh active
1999
- 1999-10-08 NO NO19994904A patent/NO314936B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU6796098A (en)	1998-10-30
NZ500592A (en)	2001-09-28
EE9900452A (et)	2000-04-17
HUP0001446A3 (en)	2001-11-28
PL336305A1 (en)	2000-06-19
BR9808513A (pt)	2000-05-23
CN1252063A (zh)	2000-05-03
HUP0001446A2 (hu)	2001-05-28
NO994904L (no)	1999-12-01
NO314936B1 (no)	2003-06-16
EA001991B1 (ru)	2001-10-22
WO1998045276A2 (fr)	1998-10-15
AR012340A1 (es)	2000-10-18
CA2284996A1 (fr)	1998-10-15
NO994904D0 (no)	1999-10-08
SK137899A3 (en)	2000-05-16
EP0973753A2 (fr)	2000-01-26
JP2002504095A (ja)	2002-02-05
IL132188A0 (en)	2001-03-19
AU734928B2 (en)	2001-06-28
EA199900907A1 (ru)	2000-04-24
TW587078B (en)	2004-05-11
WO1998045276A3 (fr)	1999-01-14
HRP980143A2 (en)	1999-02-28

Publication	Publication Date	Title
KR20010006146A (ko)	2001-01-26	Ｈｉｖ 역전사 효소 억제제로서 유용한 4,4-이치환-3,4-디히드로-2(1ｈ)-퀴나졸리논
US6423718B1 (en)	2002-07-23	4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones useful as HIV reverse transcriptase inhibitors
JP2005519910A (ja)	2005-07-07	逆転写酵素阻害剤として有用な３環ピリミドン化合物
US6127375A (en)	2000-10-03	4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinthiones useful as HIV reverse transcriptase inhibitors
US6204262B1 (en)	2001-03-20	1,3-Benzodiazepin-2-ones and 1,3-Benzoxazepin-2-ones useful as HIV reverse transcriptase inhibitors
US6946469B2 (en)	2005-09-20	Cyanamide, alkoxyamino, and urea derivatives of 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones as HIV reverse transcriptase inhibitors
CA2333643A1 (fr)	2000-01-06	Quinoline-2(1h)-ones substituees utiles comme inhibiteurs de la transcriptase inverse du vih
EP0937067B1 (fr)	2003-07-09	Urees 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cycliques utiles en tant qu'inhibiteurs de protease de vih
AU722489B2 (en)	2000-08-03	(4r,5s,6s,7r)-hexahydro-1- {5-(3-aminoinazole)methyl} -3-butyl-5,6-dihydr oxy-4,7-bis {phaenylmethyl} -2h-1,3-diazepin-2-one, its preparation and its use as HIV protease inhibitor
US6313110B1 (en)	2001-11-06	Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
US6462037B1 (en)	2002-10-08	1,4-benzodiazepin-2-ones useful as HIV reverse transcriptase inhibitors
WO2004013110A1 (fr)	2004-02-12	4,4-bisubstituees-3,4-dihydro-2(1h)-quinazoliniones utiles en tant qu'inhibiteurs de la transcriptase inverse du vih
US20010011088A1 (en)	2001-08-02	1-(3-aminoindazol-5-yl)-3-butyl-cyclic urea useful as a HIV protease inhibitor
US7015214B2 (en)	2006-03-21	Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazepine as HIV reverse transcriptase inhibitors
AU7371301A (en)	2002-02-07	4,4-disubstituted-3,4-dihydro-2-)1H)- quinazolinones useful as HIV reverse transcriptase inhibitors
US6265406B1 (en)	2001-07-24	Substituted quinolin-2 (1H) -ones useful as HIV reverse transcriptase inhibitors
CZ352499A3 (cs)	2000-02-16	4,4-Disubstituované-3,4-dihydro-2 (1H)- chinazolinony vhodné jako inhibitory HIV reverzní transkriptázy
MXPA99008909A (en)	2000-01-01	4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as hiv reverse transcriptase inhibitors
CA2330110A1 (fr)	2000-01-06	1,3-benzodiazepin-2-ones et 1,3-benzoxazepin-2-ones utilisees comme inhibiteurs de la reverse-transcriptase du vih
MXPA99004286A (en)	2000-01-01	1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors

Legal Events

Date	Code	Title	Description
1999-10-08	PA0105	International application	Patent event date: 19991008 Patent event code: PA01051R01D Comment text: International Patent Application
2001-01-26	PG1501	Laying open of application
2002-04-24	N231	Notification of change of applicant
2002-04-24	PN2301	Change of applicant	Patent event date: 20020424 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D
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2003-04-07	PA0201	Request for examination	Patent event code: PA02012R01D Patent event date: 20030407 Comment text: Request for Examination of Application
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2005-10-07	E601	Decision to refuse application
2005-10-07	PE0601	Decision on rejection of patent	Patent event date: 20051007 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20050414 Comment text: Notification of reason for refusal Patent event code: PE06011S01I