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JPS57169458A - Preparation of indole derivative - Google Patents

Preparation of indole derivative

Info

Publication number
JPS57169458A
JPS57169458A JP56054393A JP5439381A JPS57169458A JP S57169458 A JPS57169458 A JP S57169458A JP 56054393 A JP56054393 A JP 56054393A JP 5439381 A JP5439381 A JP 5439381A JP S57169458 A JPS57169458 A JP S57169458A
Authority
JP
Japan
Prior art keywords
formula
compound
indole derivative
derivative
alkyloxazolidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56054393A
Other languages
Japanese (ja)
Inventor
Kiyonori Yokogoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Original Assignee
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAAMAKEMU ASIA KK, Permachem Asia Ltd filed Critical PAAMAKEMU ASIA KK
Priority to JP56054393A priority Critical patent/JPS57169458A/en
Publication of JPS57169458A publication Critical patent/JPS57169458A/en
Pending legal-status Critical Current

Links

Landscapes

  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound which is a remedy for arrhythmia, etc. advantageously, by the condensation and ring closure of a specific formylamide compound or a reactive derivative thereof as a raw material in the presence of an alkali metallic compound e.g. CH3ONa, and neutralizing the resultant product.
CONSTITUTION: A 5-( 2-methyl-3-formylaminophenyl )-oxymethyl-3-alkyloxazolidin-2-one of formula V (Z is 5-methyl-alkyloxazolidin-2-one) or a reactive derivative thereof is subjected to the condensation and ring closure in the presence of a compound of the formula R1OM (R1 is alkyl, aryl or aralkyl; M is alkali metal), and the resultant 5-(4-indolyloxymethyl)-3-alkyloxazolidone-N1-alkali metallic salt of formula II' is neutralized with an acid to afford an indole derivative of formula II. The compound of formula II' is further hydrolyzed to afford a 4-(2-hydroxy-3-alkylaminopropoxy)indole derivative of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56054393A 1981-04-13 1981-04-13 Preparation of indole derivative Pending JPS57169458A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56054393A JPS57169458A (en) 1981-04-13 1981-04-13 Preparation of indole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56054393A JPS57169458A (en) 1981-04-13 1981-04-13 Preparation of indole derivative

Publications (1)

Publication Number Publication Date
JPS57169458A true JPS57169458A (en) 1982-10-19

Family

ID=12969433

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56054393A Pending JPS57169458A (en) 1981-04-13 1981-04-13 Preparation of indole derivative

Country Status (1)

Country Link
JP (1) JPS57169458A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399574A (en) * 1990-06-07 1995-03-21 Burroughs Wellcome Co. Indolyl tetrahydropyridines for treating migraine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399574A (en) * 1990-06-07 1995-03-21 Burroughs Wellcome Co. Indolyl tetrahydropyridines for treating migraine
US5466699A (en) * 1990-06-07 1995-11-14 Burroughs Wellcome Co. Indolyl compounds for treating migraine
US5863935A (en) * 1990-06-07 1999-01-26 Zeneca Limited Therapeutic heterocyclic compounds

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