JPS55153798A - Novel 2-substituted-adenosine 3',5'-cyclic phosphate and its preparation - Google Patents
Novel 2-substituted-adenosine 3',5'-cyclic phosphate and its preparationInfo
- Publication number
- JPS55153798A JPS55153798A JP6033779A JP6033779A JPS55153798A JP S55153798 A JPS55153798 A JP S55153798A JP 6033779 A JP6033779 A JP 6033779A JP 6033779 A JP6033779 A JP 6033779A JP S55153798 A JPS55153798 A JP S55153798A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- adenosine
- substituted
- cyclic phosphate
- carbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2-substituted-adenosine Chemical class 0.000 title abstract 4
- 229910019142 PO4 Inorganic materials 0.000 title abstract 3
- 239000010452 phosphate Substances 0.000 title abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 abstract 2
- 238000013019 agitation Methods 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002269 analeptic agent Substances 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2-substituted-adenosine 3',5'-cyclic phosphate of formula I (R is carbamoyl or carboxyl group).
USE: A medicine having an antiallergic, central nervous system stimulant, platelet aggregation, diuretic, circulatory (e.g. hypotensive and heart muscle depressant) and carcinostatic actions.
PROCESS: A 2-substituted-1, N6-etheno-adenosine 3',5'-cyclic phosphate of formula II (R' is cyano, carbamoyl or carboxyl group) is reacted with a halogenating agent, e.g. Br, Cl or N-bromosuccinimide, at 0W40°C for 1W60min under agitation to give the compound of formula I free from the etheno bridge. The addition of a basic substance, e.g. sodium hydroxide, to the system to make the pH 10W13 with agitation for several min to several hr after the reaction improves the yield of the compound of formula I remarkably.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6033779A JPS55153798A (en) | 1979-05-18 | 1979-05-18 | Novel 2-substituted-adenosine 3',5'-cyclic phosphate and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6033779A JPS55153798A (en) | 1979-05-18 | 1979-05-18 | Novel 2-substituted-adenosine 3',5'-cyclic phosphate and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55153798A true JPS55153798A (en) | 1980-11-29 |
| JPS635400B2 JPS635400B2 (en) | 1988-02-03 |
Family
ID=13139241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6033779A Granted JPS55153798A (en) | 1979-05-18 | 1979-05-18 | Novel 2-substituted-adenosine 3',5'-cyclic phosphate and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55153798A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0476584U (en) * | 1990-11-19 | 1992-07-03 | ||
| WO2000077018A3 (en) * | 1999-06-15 | 2001-12-06 | Pfizer Ltd | Purine derivatives |
-
1979
- 1979-05-18 JP JP6033779A patent/JPS55153798A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0476584U (en) * | 1990-11-19 | 1992-07-03 | ||
| WO2000077018A3 (en) * | 1999-06-15 | 2001-12-06 | Pfizer Ltd | Purine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS635400B2 (en) | 1988-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3572820D1 (en) | 1,4:3,6-dianhydro-hexite derivatives, process for their preparation and their use as medicaments | |
| JPS5587771A (en) | 1-phenylisoquinoline derivative | |
| ES472847A1 (en) | 2-Bromo-ergosine and its acid addition salts, method for its preparation and its application as a medicine. | |
| ATE41772T1 (en) | POLYMETHOXYBENZYL PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES. | |
| JPS55153798A (en) | Novel 2-substituted-adenosine 3',5'-cyclic phosphate and its preparation | |
| JPS5448798A (en) | 3-tetrazolyl-1-azaxanthone derivative and its preparation | |
| ES8801252A1 (en) | Substituted pyridazinones, method for their preparation, pharmaceutical preparation containing these compounds and their use. | |
| DE3264303D1 (en) | 1-furyl-3,4-dihydroisoquinolines, process for their preparation, their use and medicines containing them | |
| JPS5545648A (en) | 2-formyldibenzazepin derivative and its preparation | |
| JPS525755A (en) | Process for preparation of 3-amino-4-homotwistane and its acid salts | |
| JPS5651478A (en) | 3-carbamoyl-pyrazolo 1,5-a pyridine and its preparation | |
| JPS5649391A (en) | Novel bis- 8h-pyrrolo- 3,2-e -s-triazolo- 1,5-a - pyrimidinomethyl amine derivative | |
| JPS55111447A (en) | Novel 3-amino-4-homoisotwistane derivative | |
| JPS55141483A (en) | Pyridazinone derivative | |
| JPS5219647A (en) | Preparation of 3-aminomethyl-4- homoisotwistane and its acid addition salt | |
| JPS54154729A (en) | Aminobenzoic acid derivative and drug preparation containing the same | |
| ES8306729A1 (en) | Novel 2-isopropyl-pyrido[2,1-b]quinazolines and their non-toxic salts, process for their preparation and pharmaceutical compositions containing these compounds | |
| JPS5549381A (en) | 1-(3-hydroxypropyl)-3, 7-dimethylxanthine and its preparation | |
| JPS6463520A (en) | Prolactin secretion inhibitor | |
| JPS5612392A (en) | Novel camptothecin derivative and its preparation | |
| JPS57106668A (en) | Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine | |
| JPS57171983A (en) | Aminophenyltetrazole derivative and salt thereof | |
| JPS5414992A (en) | Novel cyclopropylmethylamine derivative and its preparation | |
| JPH0635435B2 (en) | Succinimide derivative | |
| JPS5579366A (en) | Preparation of 2-aminoindolenine |