JPH01280468A - Dialyzer - Google Patents

Abstract

PURPOSE:To dispense with a means to fetch an already processed dialysis liquid in the course of a sealing circuit by providing a difference between a capacity fluctuating quantity in a recovery room and a capacity fluctuating quantity in a supply room and causing it to coincide with an ultrafiltering quantity. CONSTITUTION:When a first sealing circuit 16 and a second sealing circuit 16' are simultaneously connected to a dialysis liquid room 4 of a dialyzer 1 and the fresh dialysis liquid is stably supplied from both sealing circuits 16 and 16' to the dialysis liquid room 4, the decrease of the capacity of a second variable capacity room 14', in the second sealing circuit 16' connected to the dialysis liquid room 4 of the dialyzer 1 formerly is stopped, and simultaneously, the capacity of a variable capacity room 14 in the first sealing circuit 16 connected to the dialysis liquid room 4 of the dialyzer 1 anew is gradually decreased in a fixed ratio. In such a way, by successively decreasing the capacity of the first variable capacity room 14 and the capacity of the second variable capacity room 14' in the fixed ratio, the fresh dialysis liquid can be stably supplied to the dialysis room 4 by both sealing circuits 16 and 16', and moreover, the ultrafiltering in the fixed ratio can be successively executed.

Description

DETAILED DESCRIPTION OF THE INVENTION "Field of Industrial Application" The present invention relates to a dialysis device that removes waste products and water from blood.

"Prior Art" Conventionally, in a dialysis device, the inside of a dialysate container is divided into a supply chamber and a collection chamber by a movable partition, one supply chamber is used as the inlet of the dialyzer, and the other collection chamber is used as the outlet of the dialyzer. are connected to each other to form a sealed circuit with the supply chamber, the dialyzer, and the recovery chamber, and the fresh dialysate introduced into the supply chamber is supplied to the dialyzer according to the volume reduction caused by the movement of the movable partition wall. , and at the same time, a dialyzer is known in which the treated dialysate discharged from the dialyzer is collected into the collection chamber in response to an increase in the volume of the collection chamber due to the movement of the movable partition. (
Special Publication No. 56-82).

In this type of dialysis machine, the amount of fresh dialysate supplied from the supply chamber to the dialyzer and the amount of treated dialysate collected from the dialyzer into the collection chamber can be precisely matched, so the sealing The amount of treated dialysate taken out from one part of the circuit matches the ultrafiltration rate, thus accurately controlling the amount of ultrafiltration from the amount of treated dialysate taken out of the closed circuit. be able to.

Incidentally, the fresh dialysate is usually a mixture of dilution water, a concentrated solution containing calcium ions, magnesium ions, etc., and a concentrated solution containing bicarbonate in a required ratio. Another known fresh dialysate is one in which dilution water and a concentrated solution containing acetate, etc. are mixed in a desired ratio.

Before being supplied to the supply chamber, these fresh dialysates are mixed at a predetermined ratio by the mixing device for the concentrated solution and dilution water, and then supplied from the mixing device to the supply chamber. It's full.

"Problem to be Solved by the Invention" However, in order to perform dialysis, it is necessary to discharge more treated dialysate from the dialyzer than the fresh dialysate supplied from the supply chamber to the dialyzer. In this dialysis machine, the amount of fresh dialysate supplied from the supply chamber to the dialyzer is the same as the amount of treated dialysate collected from the dialyzer into the collection chamber, so the amount of dialysate is limited to the middle of the closed circuit. A means is required to remove the treated dialysate corresponding to the amount of external filtration. In addition, in order to maintain the ultrafiltration amount per unit time stably for a long period of time, the means requires a high degree of reliability and durability, but in conventional methods, the ultrafiltration amount is based on dialysate. Since the dialysate is measured and taken out, there is a drawback that the measuring means is contaminated with the dialysate, resulting in an error in the measured value.

In addition, the mixing device for mixing and manufacturing fresh dialysate is equipped with a mixing tank to which the concentrated liquid and dilution water are supplied at a predetermined ratio, and a relatively large amount of fresh dialysate is manufactured at one time using this mixing tank. This has the disadvantage that the mixing device becomes large and requires a large amount of space.

[Means for Solving the Problems] In view of such circumstances, the present invention provides a dialysis apparatus as described above, in which a supply chamber having a movable partition is connected to the inlet of the dialyzer, and a collection chamber having a movable partition. is connected to the outlet of the dialyzer to form a sealed circuit with the supply chamber, the dialyzer, and the recovery chamber, and the fresh dialysate introduced into the supply chamber is supplied to the dialyzer as the volume of the supply chamber decreases. At the same time, the dialyzer is configured such that the treated dialysate discharged from the dialyzer is collected into the collection chamber according to an increase in the volume of the collection chamber, and the recovery chamber are separated by separate movable partitions, and the movable partition of the supply chamber and the movable partition of the recovery chamber increase or decrease the volume of the recovery chamber in accordance with the decrease or increase in the volume of the supply chamber. They are interlocked with each other via an interlocking means, and the interlocking means is provided with means for arbitrarily controlling the difference between the volume variation in the collection chamber and the volume variation in the supply chamber, and the supply chamber is provided with fresh water. The supply circuit that supplies dialysate is
A supply source of concentrated liquid connected to at least the supply chamber via a first on-off valve, and a supply source of diluted water connected to the supply chamber via a second on-off valve, When the dialysate is introduced, the movable partition of the supply chamber is moved to increase the volume of the supply chamber and the first
A dialysis device in which the on-off valve and the second on-off valve are opened alternately to sequentially introduce predetermined amounts of the concentrated liquid and dilution water into the supply chamber, thereby mixing and producing fresh dialysate within the supply chamber. It provides:

"Operation" According to the above configuration, the difference between the volume variation in the recovery chamber and the volume variation in the supply chamber can be made to match the ultraviolet source AN, so that the process can be performed in the middle of the sealed circuit as in the conventional case. No means for taking out the finished dialysate is required, making it easier to ensure reliability and durability compared to the case where such means is provided. Since the amount of ultrafiltration can be controlled by the magnitude of the difference in volume fluctuation, the amount of ultrafiltration can be controlled more reliably than when the treated dialysate is taken directly from the closed circuit. can.

Further, by alternately opening the first on-off valve and the second on-off valve, the concentrated liquid and the dilution water are sequentially introduced in predetermined amounts into the supply chamber, thereby mixing and producing fresh dialysate in the supply chamber. Therefore, there is no need to provide a separate mixing tank as in the conventional case, and the overall size of the apparatus can be reduced.

``Example'' The present invention will be described below with reference to the illustrated example. In FIG. Blood, which is a liquid to be treated, is introduced into the liquid chamber 3 through a supply path 5 and can be discharged to the outside through a discharge path 6.

In this embodiment, two first dialysate containers 10 and a second dialysate container lO' are arranged in parallel, and each dialysate container 10
110' alternately supplies and discharges fresh dialysate to and from the dialyzer 1 so that dialysis can be performed accordingly. The first dialysate container 1o and the second dialysate container 10'
Since they have substantially the same configuration, only the configuration of the first dialysate container 10 will be explained, and the configuration of the second dialysate container 1 will be explained.
1 for 0'. The same parts as the first dialysate container IO are indicated by adding "'" to the reference numerals used for the first dialysate container 10, and the explanation of the structure thereof will be omitted.

The inside of the first dialysate container IO is divided into three chambers by two diaphragms 11 and 12 as movable partitions, namely, a first supply chamber 13, a first variable volume chamber 14, and a first collection chamber. The fresh dialysate produced in the first supply chamber 13, which is divided into 15 compartments and formed on one side of the first dialysate container IO, is transferred to the dialysate chamber 4 of the dialyzer 1 through the first sealed circuit 16. A first collection chamber 1 is formed on the other side of the first dialysate container IO to supply the treated dialysate from inside the dialysate chamber 4.
We aim to collect the items within 5 days. Note that the diaphragms 11 and 12 do not need to be completely separate bodies, and may be partially connected together.

The first sealed circuit 16 connects the first supply chamber 13 to a first
It communicates with the dialysate chamber 4 through a supply path 17, a first supply valve 18, a filter 19, a common supply path 20, and a constant flow valve 21, and further includes a common recovery path 22, a pump 23, a deaerator 24, a first The first recovery chamber 15 is communicated with the first recovery chamber 15 through a recovery path 25 and a first recovery valve 26 .

A liquid 30 such as silicone oil is sealed in the central first variable volume chamber 14 formed in the first dialysate container IO, and when one diaphragm 11 moves, the liquid 30 The other diaphragm 12 can be displaced to follow the diaphragm 11 through the diaphragm 11. In this embodiment, therefore, the liquid 30 constitutes interlocking means for interlocking the two diaphragms 11,12.

゛The first variable volume chamber is communicated with the inside of the cylinder chamber 32 of the cylinder device 31, and by moving the piston 34 of the cylinder device 31 forward and backward by the servo motor 33, the inside of the first variable volume chamber 14 is communicated with the inside of the first variable volume chamber 14. The volume can be adjusted. This cylinder device 31 greatly controls the volume of the first variable volume chamber I4 when the diaphragm 11.12 moves to the right, and the diaphragm It,1
2 moves to the left, the volume of the first variable volume chamber 14 is controlled to be small.

As a result, the volume fluctuation (2) in the first recovery chamber 15 is larger than the volume fluctuation in the first supply chamber 13.
It increases by the volume variation of the first variable volume chamber 14 due to the change in the volume of the first variable volume chamber 14. Therefore, more processed dialysate can be collected into the first collection chamber 15 by the above-mentioned volume variation than the fresh dialysate supplied from the first supply chamber 13 to the dialyzer 1, and the volume variation is This corresponds to the amount of ultrafiltration by vessel 1.

By the way, the filter l9 provided in the first supply path 17 is designed to allow the flow of the dialysate but to block the flow of the liquid 30, and if the diaphragm 11 is damaged, the liquid 30 will flow into the first supply chamber. Even if it leaks into the dialyzer 13, it is prevented from being supplied to the dialyzer 1.

Further, a detection means 35 for detecting the liquid 30 is provided on the upstream side of the filter 19, for example, when colored silicone oil is used as the liquid 30, a phototube 35 is provided to detect that the dialysate has been colored by the silicone oil. By detecting this, it is possible to detect that the diaphragm 11 is damaged.

On the other hand, damage to the diaphragm 12 can be detected by detection of silicone oil by a blood leakage sensor 36, which will be described later.

Note that a filter 19' corresponding to the filter 19 described above is also provided in the second closed circuit 16' on the second dialysate container 10' side, and the diaphragm 11' of the second dialysate container 10' is damaged by the filter 19'. However, in order to simplify the configuration, only one filter may be provided in the common supply path 20.

Further, as the detection means 35, an appropriate one can be used in consideration of the liquid 30 to be used.An example of another detection means using the silicone oil as the liquid 30 is the detection means 35 on the upstream side of the filter 19. A transparent tube may be provided in part or all of the second supply path 17 so that the colored state caused by the silicone oil can be visually observed from the outside.

Next, the first supply chamber 13 and the second supply chamber 13 of the first dialysate container IO are
A supply circuit 40 for alternately supplying fresh salmon dialysate to the first supply chamber 13' of the dialysate container 10' has a dilution water supply source 41 and a concentrated liquid containing calcium ions, magnesium ions, etc. (hereinafter referred to as A). A supply source 42 of a bicarbonate-containing vA thickness a (hereinafter referred to as a B liquid) is provided.

The dilution water supply source 41 includes a common introduction path 44, a manual on-off valve 45, a heater 46, a pump 47, a deaerator 48, an electromagnetic diluent on-off valve 49, a first introduction path 50, and a first introduction valve 51. communicates with the first supply chamber 13 via the
It communicates with the second supply chamber 13' via a second introduction passage 50' branched and connected to the introduction passage 50 and a second introduction valve 51'.

Then, the outlet side of the pump 47 and the inlet side of the heater 46 are communicated via a bypass passage 52.
When the solenoid on-off valve 49 is closed while the
When the pressure on the discharge side of the pump 47 exceeds the set pressure of a relief valve 53 provided in the bypass path 52, dilution water can be circulated through the bypass path 52 and the relief valve 53. .

Further, the supply source 42 of the liquid A and the supply source 43 of the liquid B are as follows:
The diluent liquid on-off valve 49 and both introduction passages 50 and 50' are connected to the diluent liquid on-off valve 49 and both inlet passages 50 and 50' via electromagnetic type A liquid on-off valve 54 and B liquid on-off valve 55, respectively.
It is connected to a common introduction path 44 between the branch point and the branch point.

Further, a waste circuit 56 for discarding the treated dialysate from the first collection chamber 15 includes a first waste path 57 connected to the first recovery chamber 15, a first waste valve 58 provided therein, and a common waste path 59. The blood can then be disposed of into a collection tank (not shown) via the blood leakage sensor 36 mentioned above. Further, this waste circuit 56 is connected to the second recovery chamber 15' and a second waste path 57'.
Of course, the second waste valve 58' is also provided.

In addition, the opening and closing of each solenoid valve mentioned above and the servo motor 33.3
The rotation of 3' is controlled by a control device including a microcomputer (not shown).

In the above configuration, at a certain time Ta shown in FIG. 2, the first supply valve 18 and the first
Recovery valve 26 is closed, and first inlet valve 51 and first waste valve 58 are open. In contrast, the second sealed circuit 16
', contrary to the first sealed circuit 16, the second supply valve 1
8' and the second recovery valve 26' are opened, and the second inlet valve 5
1' and second waste valve 58' are closed. Therefore, in this state, the second closed circuit 16' is connected to the dialysate chamber 4 of the dialyzer 1, and the first closed circuit 16 is disconnected from the dialysate chamber 4.

In this state, a predetermined amount of liquid A and liquid B have already been introduced into the first supply chamber 13, the liquid A on-off valve 54 and the liquid B on-off valve 55 are closed, and the diluent liquid on-off valve 49 is closed. It is opened and the diluent is introduced into the first supply chamber 13, whereby fresh dialysate is being mixed and produced in the first supply chamber 13. As the diluent is introduced into the first supply chamber 13, the diaphragms 11 and 12 are moved together, thereby reducing the volume of the first collection chamber 15 and allowing the processed dialysate inside the chamber to decrease. or is discharged to the outside via a waste channel 59.

On the other hand, the fresh dialysate in the second supply chamber 13' is supplied to the constant flow valve 2.
1, the dialysate is supplied into the dialysate chamber 4 of the dialyzer 1 at a constant flow rate, and the processed dialysate from the dialysate chamber 4 is collected into the second recovery chamber 15'. At this time, the cylinder device 31' gradually reduces the volume of the second variable volume chamber 14' at a constant rate, so that the second supply chamber 13'
A larger amount of treated dialysate is gradually collected into the second collection chamber 15' than the amount of fresh dialysate supplied into the dialysate chamber 4 from ', and the difference becomes the ultrafiltration amount in the dialyzer 1. ing.

Supply time T1 for supplying fresh dialysate to the dialysate chamber 4 from within each supply chamber 13.13' in the first closed circuit 16 and the second closed circuit 16', that is, each supply valve 18.18
' and the time T1 for which the recovery valve 26, 26' is kept open.
is preset at a suitable time before the fresh dialysate in the supply chamber is completely consumed, based on the volume in each supply chamber I3.13' and the constant flow rate controlled by the constant flow valve 21. It is.

On the other hand, the introduction time T2. during which fresh dialysate is introduced into each supply chamber 13, 13' via the introduction channel 44. That is, the introduction valve 51
．． 36' and waste valves 58, 37' are kept open, T2 is set to be shorter than the supply time T1. Based on the difference between the placement times T1 and T2,
The first supply valve 18 and the second supply valve 18' are operated for a predetermined period T.
It is possible to open-i-by overlapping the two.

Next, when the predetermined introduction time T2 in the first sealed circuit 16 has elapsed at time Tb shown in FIG. 2, fresh dialysate has already been mixed and produced in the first supply chamber 13 and filled and the diaphragm 11.
12 is located at the right end. In this state, since the first supply chamber 13 is full, the dilution water from the pump 47 is circulated through the pump 47 via the bypass path 52 and the relief valve 53, and is further circulated through the first variable volume chamber 14. has the largest volume.

At the time Tb, the dilution water on-off valve 49 is closed, and each valve in the first sealed circuit 16 is switched simultaneously to open the first supply valve 18 and the first recovery valve 26, and the first introduction valve 49 is closed. Valve 51 and first waste valve 58 are closed. As a result, the first sealed circuit 16 as well as the second sealed circuit 16' are connected to the dialysate chamber 4 of the dialyzer 1, so that the fresh dialysate in the first supply chamber 13 and the second supply chamber 13' is supplied to the dialyzer 1. is supplied into the dialysate chamber 4 of the dialysate chamber 4.
The processed dialysate from the inside is transferred to the first collection chamber 15 and the second collection chamber 1.
It will be recovered within 5'. Note that even in this state, the fresh dialysate supplied into the dialysate chamber 4 of the dialyzer 1 is of course adjusted to a constant flow rate by the constant flow valve 21.

The first sealed circuit 16 and the second sealed circuit 16' are connected to the dialysate chamber 4 of the dialyzer 1 at the same time, so that the two dialysis circuits 16,'
When fresh dialysate is stably supplied from 16' to the dialysate chamber 4, at time Tc in FIG. '
At the same time, the volume of the first variable volume chamber 14 in the first sealed circuit 16 newly connected to the dialysate chamber 4 of the dialyzer 1 is kept constant. will be gradually reduced at a rate of .

In this way, by successively decreasing the volume of the first variable volume chamber 14 and the volume of the second variable volume chamber 14' at a constant rate, the dialysis fluid chamber is Coupled with the ability to stably supply fresh dialysate to 4, it is possible to continuously perform ultrafiltration at a constant rate.

Next, at time Td in FIG. 2, when the supply time T1 in the second sealed circuit 16' has elapsed, the second sealed circuit 16'
The second supply valve 18' and the second recovery valve 26' are closed, and the second inlet valve 51' is opened, but the second waste valve 58' remains closed. . Then, by closing the second supply valve 18' and the second recovery valve 26', the second closed circuit 16' and the dialysate chamber 4 of the dialyzer 1 are closed.
The first closed circuit 16 is connected to the dialysate chamber 4.
Fresh dialysate is supplied only from the

Then, at the above-mentioned time Td, when the second inlet valve 51' is opened while the second waste valve 58' is closed, the A liquid on-off valve 54 is first opened, and then the volume of the second variable volume chamber 14' is It is reduced to a predetermined amount. Then, since the diaphragm 12' cannot move because the second waste valve 58' is closed, only the diaphragm 11' operates to increase the volume inside the second supply chamber 13', thereby discharging liquid A. A predetermined amount of liquid A is sucked into the second supply chamber 13' from the supply source 42 through the liquid A on-off valve 54.

After introducing a predetermined amount of liquid A into the second supply chamber 13' in this way, at time Te, the liquid A on-off valve 54 is closed and the liquid B on-off valve 55 is opened. The volume of the second variable volume chamber 14' is reduced to a predetermined amount. This causes the second
A liquid B on-off valve 55 is connected to the liquid B supply source 43 in the supply chamber 13'.
A predetermined amount of liquid B is sucked and introduced through the .

Next, when predetermined amounts of liquid A and liquid B are introduced into the second supply chamber 13', the liquid B on-off valve 5 is opened at time Tf.
5 is closed and the dilution water on/off valve 49 is opened.
Furthermore, the second waste valve 58' is also opened.

Then, the diluent is forced into the second supply chamber 13' by the pump 47 via the dilution water on-off valve 49, and the diaphragms 11 and 12 are integrally moved to the right and the second recovery The treated dialysate in chamber 15' is transferred to waste channel 5.
It is discharged to the outside via 9. During this period, the cylinder device 31' rapidly returns the volume of the second variable volume chamber 14' from the aforementioned reduced state to the maximum state.

This state is a closed state in which the state of the first sealed circuit 16 and the state of the second sealed circuit 16' at the above-mentioned time Ta are reversed. The action is repeated. and each sealed circuit 16.
16' are alternately connected to the dialysate chamber 4 of the dialyzer 1 while overlapping for a predetermined time T, so that fresh dialysate can be stably and continuously supplied to the dialysate chamber 4, thereby achieving the above-mentioned effect. Continuous and smooth ultrafiltration can be performed.

In the above embodiment, the cylinder devices 31, 31' are controlled separately by the servo motors 33, 33', but the invention is not limited to this, and the driving sources for both cylinder devices 31, 31' can be controlled by an appropriate configuration. It is also possible to share.

Further, when mixing and manufacturing fresh dialysate, liquid A, liquid B, and diluted liquid are mixed in that order, but the method is not limited thereto. For example, first, the diluted liquid is introduced to approximately the intermediate amount by time management, then predetermined amounts of liquids A and B are sequentially introduced as in the above embodiment, and finally the diluted liquid is again introduced into the supply chamber 13.13. It is also possible to introduce the battery until it becomes full.

Furthermore, in the above embodiment, two types of concentrated liquid supply sources 42 and 43, liquid A and liquid B, are provided, but depending on the type of dialysate used, there may be one or three or more concentrated liquid sources. Of course it will.

Next, FIG. 3 shows another embodiment of the present invention, in which the first dialysate container 110 in this embodiment is constructed by replacing the first dialysate container in the above embodiment with a diaphragm lll, 11
The variable volume chambers 114, 114 formed in each container 170, 171 are communicated with each other via a conduit 17.2, and the conduit Cylinder device 13 at 172
1 cylinder chamber 132 is connected. Further, the second dialysate container 110' has a similar configuration, and the same parts as the first dialysate container 110 are indicated by the same reference numerals with a ``''' added thereto.

Furthermore, in this embodiment, each supply chamber 113, 113
Three-way switching valves 173, 173 are used in place of the supply valves 18, 18' and the inlet valves 51, 51', respectively, to connect the dialysate chamber 104 of the dialyzer 101 or the fresh dialysate supply circuit 140 respectively. Similarly, using recovery valve 2
Three-way valves 174, 174' are used in place of the waste valves 6.26' and 58.58'. Furthermore, in each supply chamber 113.11: l', liquid A and B/
In order to introduce &, an electromagnetic on-off valve 175 is provided in the waste circuit 156.

The rest of the structure is not substantially different from the embodiment described above, and the same parts as those of the embodiment described above are indicated by the same reference numerals plus 100. It is clear that the same effects as in the above embodiment can be obtained in this embodiment as well.

FIG. 4 shows another embodiment of the portion corresponding to each dialysate container described above, and the dialysate container 210 of this embodiment has a piston rod 282 interlocked with a piston 281 of a cylinder device 280 as a fulcrum. It is connected at a connecting point 285 to a swinging arm 284 that swings about 283, and
A piston rod 288 that is linked to a piston 287 of another cylinder device 286 is connected to the swing arm 284 at a connection point 289.

One connection point 289 is located farther from the fulcrum 283 than the other connection point 285, so that when the swing arm 284 swings, the cylinder multiplier device 2
By making the piston strokes of 80 and 286 different, the amount of volume fluctuation in the recovery chamber 215 formed in the cylinder device 286 by the piston 287 as a movable partition is changed by the piston 281 as a movable partition. The amount of variation in volume of the supply chamber 213 is set to be larger than the amount of variation in volume of the supply chamber 213 formed in the above.

Further, a two-stage actuation type cylinder device 290 is provided in the middle of the piston rod 282 on the side of the supply chamber 213, and when the swing arm 284 is fixed at a predetermined position by a stopper 291, the cylinder device 290 The first stage of operation sucks the liquid A into the supply chamber 213, and the second stage of operation successively sucks liquid B into the supply chamber 213. Furthermore, the connection point 285.2
At least one of the swing arms 89 is adjustable in position in the longitudinal direction of the swing arm 284, so that the difference in volume variation can be adjusted by warping.

It goes without saying that even if some of the dialysate containers in the embodiments described above are configured as shown in FIG. 4, the same effects as described above can be obtained.

"Effects of the Invention" As described above, the present invention makes it possible to make a difference between the volume variation in the collection chamber and the volume variation in the supply chamber and make it match the ultrafiltration rate, which is different from the conventional method. does not require a means to take out the treated dialysate in the middle of the closed circuit,
Therefore, reliability and durability can be ensured more easily than when such means are provided. In addition, if it is necessary to change the ultrafiltration rate, it can be adjusted by controlling the difference in volume fluctuation between the collection chamber and the supply chamber, so the ultrafiltration rate can be adjusted directly from the sealed circuit. Compared to the case where the dialysate is taken out, the effect that the amount of ultrafiltration can be easily and reliably controlled is obtained.

Further, by alternately opening the first on-off valve and the second on-off valve, a predetermined amount of concentrated fresh dialysate and diluted water are sequentially introduced into the supply chamber, thereby mixing the fresh dialysate in the supply chamber. Since it can be manufactured, there is no need to provide a separate mixing tank as in the conventional case, and the effect that the entire apparatus can be made smaller is achieved.

[Brief explanation of the drawing]

Fig. 1 is a system diagram showing one embodiment of the present invention, and Fig. 2 is a system diagram showing an embodiment of the present invention.
FIG. 3 is a system diagram showing another embodiment, and FIG. 4 is a schematic configuration diagram of main parts showing still another embodiment. 1.101...Dylyzer 10.10', 110,110', 210...
Dialysate containers 11.11', 12.12', I
ll, Ill', 112, 112'...Diaphragm (as far as rotation 13.13', 113, 113', 21:l...
・Supply chamber 15.15', 115,115', 2+
5... Collection chamber 16.16', 116, 116'.
... Sealed circuit 30.30', 130,130'...
-Liquid (interlocking means) 40.140...Supply circuit 41.141...Dilution water supply source 42.142...A liquid supply source 43.14:ll-...B liquid supply source 49 , 149... Dilution water on/off valve 54.154... A liquid on/off valve 55.155... B liquid on/off valve

Claims (1)

Claims: A supply chamber with a movable partition is connected to the inlet of the dialyzer, while a collection chamber with a movable partition is connected to the outlet of the dialyzer and sealed between the supply chamber, the dialyzer and the recovery chamber. A circuit is formed such that fresh dialysate introduced into the supply chamber is supplied to the dialyzer as the volume of the supply chamber decreases, and at the same time, treated dialysate discharged from the dialyzer is supplied to the recovery chamber. The dialysis device is configured to be recovered into the recovery chamber as the volume increases, and the supply chamber and the recovery chamber are separated by separate movable partitions, and the movable partition of the supply chamber and the recovery chamber are separated from each other by separate movable partitions. The movable partition wall is interlocked with each other via an interlocking means that increases or decreases the volume of the collection chamber in response to a decrease or increase in the volume of the supply chamber,
and the interlocking means is provided with means for arbitrarily controlling the difference between the volume variation in the collection chamber and the volume variation in the supply chamber, and a supply circuit for supplying fresh dialysate to the supply chamber,
A supply source of concentrated liquid connected to at least the supply chamber via a first on-off valve, and a supply source of diluted water connected to the supply chamber via a second on-off valve, When the dialysate is introduced, the movable partition wall of the supply chamber is moved to increase the volume of the supply chamber, and the first on-off valve and the second on-off valve are alternately opened so that the concentrated liquid and A dialysis apparatus characterized in that a predetermined amount of dilution water is sequentially introduced into a supply chamber, whereby fresh dialysate is mixed and manufactured within the supply chamber.