JPH09263513A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject preparation less prone to be discolored with light and useful as a cosmetic little in a foreign smell by stably compounding a beautifully whitening agent. SOLUTION: This preparation for external uses for skins contains one or more kinds of compounds selected from the group consisting of L-ascorbic acid and its derivative (e.g. a L-ascorbic acid alkyl ester), hydroquinone glycoside and its derivative (e.g. hydroquinone α-D-glucose), kojic acid and its derivative (e.g. a kojic acid alkyl ester), an UV light absorbent and dibutylhydroxytoluene. The further addition of one or more kinds of compounds selected from a metal ion-blocking agent, a divalent metal salt, a trivalent metal salt, sulfurous acid and its salt, hydrogen sulfite and its salt, thiosulfuric acid and its salt, pyrosulfurous acid and its salt to the preparation for the external uses furthermore improves the stability of the contained derivative.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin containing a whitening agent, more specifically, L- as a whitening agent.
The present invention relates to a skin external preparation containing ascorbic acid and a derivative thereof, hydroquinone glycoside and a derivative thereof, and kojic acid and a derivative thereof, which are stably blended and hardly discolored by light.

[0002]

2. Description of the Related Art Conventionally, L-ascorbic acid and its derivatives, hydroquinone glycosides and their derivatives, in order to have an excellent whitening effect in external preparations for skin,
Kojic acid and its derivatives are included. For example,
Ascorbic acid suppresses the biosynthesis of dopaquinone, which is a metabolic intermediate in the process of melanin production, to dopachrome, and also has the action of returning the produced dark-colored oxidized melanin to light-colored reduced melanin, whitening skin, stains, It is a compound effective for treating and improving freckles, melanosis, liver plaque, etc.

[0003]

However, the above-mentioned whitening agent is chemically unstable, and when it is mixed with an external skin preparation, it is decomposed over time or by light, and tends to cause coloration or odor. Therefore, it has been proposed to add an antioxidant or a reducing agent to the external preparation for the skin, but none of those having sufficient stability has been obtained.

The present invention has been made to solve such conventional problems, and L-ascorbic acid and its derivatives, hydroquinone glycosides and their derivatives,
An object is to provide an external preparation for skin in which kojic acid and its derivative are stably mixed.

[0005]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that L-ascorbic acid and its derivatives, hydroquinone glycosides and their derivatives, and kojic acid and its derivatives. The combined use of one or more selected from the group consisting of an ultraviolet absorber and dibutylhydroxytoluene in the external preparation for the skin suppresses the decomposition of the whitening agent due to light, and discolors or discolors the external preparation for the skin. The inventors have found that odor can be reduced, and have completed the present invention.

That is, the present invention provides one or more selected from the group consisting of L-ascorbic acid and its derivatives, hydroquinone glycosides and its derivatives, kojic acid and its derivatives, and an ultraviolet absorber. A skin external preparation characterized by being mixed with dibutylhydroxytoluene.

Hereinafter, the configuration of the present invention will be described in detail. The L-ascorbic acid used in the present invention is generally referred to as vitamin C, and due to its strong reducing action, has a cell respiration action, an enzyme activating action, a collagen forming action, and a melanin reducing action. Examples of the L-ascorbic acid derivative include L-ascorbic acid alkyl ester, L-ascorbic acid phosphoric acid ester, and L-ascorbic acid sulfuric acid ester. Specific examples include palmitic acid L-
Ascorbyl, L-ascorbyl isopalmitate, L-ascorbyl dipalmitate, L-isopalmitic acid L
-Ascorbyl, L-ascorbyl stearate, L-Ascorbyl isostearate, L-Ascorbyl distearate, L-Ascorbyl diisostearate, L-Ascorbyl myristate, L-Ascorbyl isomyristate, L-Ascorbyl dimyristate, Diisomyristin Acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbyl, dioleic acid L
-L-ascorbic acid alkyl ether such as ascorbyl, L-ascorbic acid-2-phosphate ester, L-ascorbic acid-3-phosphate ester, DL-α-tocopherol-2-L-ascorbic acid phosphate diester Examples thereof include L-ascorbic acid phosphoric acid ester, L-ascorbic acid-2-sulfuric acid ester, L-ascorbic acid-3-sulfuric acid ester, and other L-ascorbic acid sulfuric acid esters. In the present invention, these salts can also be used, and alkali metal salts such as sodium salt and potassium salt, and alkaline earth metal salts such as calcium salt and magnesium salt are preferably used. The above-mentioned L-ascorbic acid or its derivative is mainly obtained by a known synthetic method, but of course, those obtained by other methods can also be used, and a commercially available vitamin C derivative is used. It is possible.

Examples of the kojic acid derivative used in the present invention include kojic acid esters such as kojic acid alkyl ester and kojic acid ethers such as kojic acid alkyl ether.

Examples of hydroquinone glycosides used in the present invention include hydroquinone α-D-glucose, hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, and hydroquinone α-D. -Galactose, hydroquinone β-D-galactose, hydroquinone α-L-
Hexaglycoside glycosides such as galactose and hydroquinone β-L-galactose, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L
-Ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D
-Pentacarbon glycosides such as arabinose, hydroquinone α-L-arabinose and hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-
Glucosamine, hydroquinone β-L-glucosamine,
Amino acid glycosides such as hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuronic acid, Hydroquinone α-L-glucuronic acid, Hydroquinone β-L-
Glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L
Examples thereof include uronic acid glycosides such as galacturonic acid, and derivatives thereof include ester bodies such as acetylated products and ether bodies such as methylated products. Of these, hydroquinone β-D-glucose (generic name: arbutin, hereinafter referred to as arbutin) is preferably used from the viewpoints of whitening effect, easy availability, stability and the like. In carrying out the present invention, one kind or two or more kinds are appropriately selected and mixed from these.

L- compounded in the external preparation for skin according to the present invention
The amount of one or more selected from the group consisting of ascorbic acid and its derivatives, hydroquinone glycosides and their derivatives, kojic acid and its derivatives is not particularly limited, but generally it is based on the total skin external preparation. 0.0
It is preferably from 0 to 15.0% by weight, and is 0.0 in terms of whitening effect and no adverse effects such as stickiness as an external skin preparation.
1 to 10.0% by weight is particularly preferred.

As the ultraviolet absorber used in the present invention, para-aminobenzoic acid (hereinafter abbreviated as PABA),
PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PAB
A ethyl ester, N, N-dimethyl PABA methyl ester, N, N-dimethyl PABA ethyl ester,
N, N-dimethylbutyl ester, N, N-dimethyl P
Benzoic acid type UV absorbers such as ABA2-ethylhexyl ester, anthranilic acid type UV absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p. -Salicylic acid-based UV absorbers such as isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropyl cinnamate,
Methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,
4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2 -Ethoxyethyl-
p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-
Cinnamic acid-based UV absorbers such as phenylcinnamate and glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, 2,4-dihydroxybenzophenone,
2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2'4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2 -Hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4-phenyl-benzophenone-2-carboxylate, 2- Hydroxy-4-n
Benzophenone-based UV absorbers such as octoxybenzophenone and 4-hydroxy-3-carboxybenzophenone, 3- (4-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor, urocanic acid ethyl ester , 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-
5-methylphenylbenzotriazole, dibenzalacin, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3'dimethyl-
2-Norbornylidene) -3-pentan-2-one and the like can be used.

Among these ultraviolet absorbers, U is particularly preferable.
An ultraviolet absorber having an absorption ability for ultraviolet rays in the VA region, for example, 4-methoxy-4′-t-butyldibenzoylmethane, and an ultraviolet absorber having an absorption ability for ultraviolet rays in the UV-B region, For example, N, N-dimethyl PABA2-
The effect of the present invention is further improved by combining with ethylhexyl ester, 2-methoxyhexyl paramethoxycinnamate and the like. Similarly, 2-hydroxy-4-, which has absorption ability for ultraviolet rays in the UV-A and UV-B regions.
The effect is improved by using methoxybenzophenone-5-sulfonate or the like. The amount of the ultraviolet absorber compounded in the external preparation for skin is 0.01 to 1.
It is 0% by weight, more preferably 0.02 to 0.5% by weight. If it is less than 0.01% by weight, no stabilizing effect is observed,
Even if the amount is more than 1.0% by weight, no improvement in the effect is observed.

The dibutylhydroxytoluene (hereinafter referred to as BHT) used in the present invention is a fat-soluble antioxidant and is used as a stabilizer for vitamin A and the like. The content of BHT in the external preparation for skin is 0.0001 to 0.1% by weight, more preferably 0.001 to 0.01% by weight, based on the total amount of the external preparation for skin. If it is less than 0.0001% by weight, the stabilizing effect is not recognized, and if it exceeds 0.1% by weight, the effect is not improved.

In the present invention, (1) sequestering agent, (2) divalent and / or trivalent metal salt, (3) sulfurous acid and its salt, hydrogen sulfite and its salt, thiosulfuric acid and its salt, Stabilization against L-ascorbic acid and its derivatives, hydroquinone glycosides and their derivatives, kojic acid and its derivatives by further blending one or more selected from pyrosulfurous acid and its salts. The chemical effect can be further enhanced. Further, by using (1) and (3) or (2) and (3) together, the stabilizing effect becomes more excellent.

Examples of the sequestering agent used in the present invention include 1-hydroxyethane-1,1 diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, edetate disodium and edetate trihydrate. Examples thereof include sodium, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, and edetic acid. The amount of the sequestering agent added to the external preparation for skin is 0.001 to the total amount of the external preparation for skin.
It is 1.0% by weight, more preferably 0.005-0.5% by weight. Even if compounded in an amount of more than 1.0% by weight, no improvement in the stabilizing effect is observed.

Divalent and / or 3 used in the present invention
As the valent metal salt, any of those commonly used in cosmetics and pharmaceuticals may be used, and chlorides such as magnesium chloride, calcium chloride and zinc chloride, and sulfuric acid such as ferrous sulfate, magnesium sulfate and aluminum sulfate. Examples thereof include salt. The content of the polyvalent metal salt in the external preparation for skin is 0.0001 to 1.0% by weight in the total amount of the external preparation for skin,
It is more preferably 0.001 to 0.1% by weight. 1.
No improvement in the stabilizing effect is observed even if the content exceeds 0% by weight.

Sulfurous acid and salts thereof used in the present invention,
The compounding amount of hydrogen sulfite and its salt, thiosulfuric acid and its salt, pyrosulfurous acid and its salt is 0.
0001 to 1.0% by weight, more preferably 0.0
0.01 to 0.1% by weight. Even if compounded in an amount of more than 1.0% by weight, no improvement in the stabilizing effect is observed.

In the present invention, in addition to the above-mentioned essential components, if necessary, other components such as oil, surfactant,
Preservatives, moisturizers, thickeners, powders, fragrances and the like, which are usually used in cosmetics, can be appropriately added. The external preparation for skin of the present invention can be produced by a usual method, and can be applied, for example, as a basic cosmetic, a cosmeceutical, a pharmaceutical base for external use and the like.

[0019]

EXAMPLES Next, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples. All amounts are by weight.

Examples 1 to 8 and Comparative Examples 1 to 10 According to the formulations shown in Tables 1 to 3, lotions were produced by a conventional method, and the light stability was evaluated. The light stability test / evaluation method is as follows.

(Light Stability Test) Each sample was subjected to a sun exposure test for 10 days, and changes in color and odor with respect to a product stored at 0 ° C. were evaluated as follows.

(Color) A: No change ○: Very slightly discolored. Δ: Slightly discolored. X: Strongly discolored.

(Smell) ⊚: No change ◯: Slight odor. Δ: Slight odor. X: Strong odor.

[0024]

[Table 1] ─────────────────────────────────── Examples Comparative examples ─────── ──────── 1 2 1 2 3 3 ─────────────────────────────────── phosphoric acid -L-ascorbyl magnesium 1.0 1.0 1.0 1.0 1.0 (APM) 2-hydroxy-4-methoxy benzophenone-5-sulfonate 0.05 0.05 0.05 --- BHT 0.01 0.01-0.01-Trisodium edetate 0.01 ------ 1,3 -Butylene glycol 5.0 5.0 5.0 5.0 5.0 Ethanol 5.0 5.0 5.0 5.0 5.0 POE (15) oleyl alcohol ether 0.5 0.5 0.5 0.5 0.5 Citric acid 0.02 0.02 0.02 0.02 0.02 Sodium citrate 0.08 0.08 0.08 0.08 0.08 Preservative 0.1 0.1 0.1 0.1 0.1 Distilled water Residual Residual Residual Residual ────────────────────────── ────────── Color ◎ ○ × △ × Odor ◎ ◎ △ ○ △ ──────────────────────────── ───────

[0025]

[Table 2] ─────────────────────────────────── Example ────────── ────────── 3 4 5 6 7 8 ────────────────────────────────── ─ L-ascorbic acid-2-sulfate 2.0 2.0 2.0 2.0 − − Arbutin − − − − 5.0 − Kojic acid − − − − − 2.0 2-Hydroxy-4-methoxybenzophenone-5-sulfonate 0.05 0.05 0.05 0.05 0.05 0.05 BHT 0.01 0.01 0.01 0.01 0.01 0.01 1,3-butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 Ethanol 5.0 5.0 5.0 5.0 5.0 5.0 POE (15) oleyl alcohol ether 0.5 0.5 0.5 0.5 0.5 0.5 citric acid 0.02 0.02 0.02 0.02 0.02 0.02 citric acid Sodium 0.08 0.08 0.08 0.08 0.08 0.08 Trisodium edetate − 0.02 − 0.02 0.02 0.02 Preservative 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Sulfate No. Iron 0.0005 − − − − − Sodium pyrosulfite − − − 0.01 − − Distilled water Residual residue Residual residue Residual residue ─────────────────────────── ───────── Color ◎ ◎ ○ ◎ ○ ○ Odor ◎ ○ ○ ◎ ◎ ◎ ◎ ──────────────────────────── ────────

[0026]

[Table 3] ─────────────────────────────────── Comparative example ───────── ─────────── 4 5 6 7 8 9 10 ──────────────────────────────── ─── L-Ascorbic acid-2-sulfate 2.0 2.0 2.0 2.0 2.0 − − Arbutin − − − − − 5.0 − Kojic acid − − − − − − 2.0 2-Hydroxy-4-methoxybenzophenone 5-sulfonate 0.05 − − 0.05 − − − BHT − 0.01 − − 0.01 − − 1,3-Butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Ethanol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 POE (15) Oleyl alcohol ether 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Acid 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Sodium citrate 0.08 0.08 0.08 0.08 0.08 0.08 0.08 Trisodium edetate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Preservative 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Ferrous sulfate 0.0005 0.0005 − − − − − Sodium pyrosulfite − − − 0.01 0.01 − − Distilled water Residual Residual Residual Residual Residual Residual ─────────── ──────────────────────── Color × △ × × △ × × Odor △ ○ △ △ ○ ○ ○ ─────────── ─────────────────────────

As described above, the cosmetic of the present invention is excellent in light stability.

Example 9 Emulsion A Vaseline 1.0 wt% liquid paraffin 2.0 POE (20) oleic acid 1.0 glycerin monooleate 1.0 octyl-p-methoxycinnamate 0.05 4-methoxy-4 ′ -t-Butyldibenzoylmethane 0.05 BHT 0.01 Preservative 0.2 Perfume 0.1 B Propylene glycol 1.0 Kojic acid 1.0 Distilled water Residual (manufacturing method) Raw material of oil phase part belonging to A and B The raw materials of the water phase part belonging to (3) are heated to 70 ° C. and completely dissolved, and then the oil phase part is mixed with the water phase part and emulsified by an emulsifying machine. The emulsion is cooled with a heat exchanger to a final temperature of 30 ° C.

Example 10 Cream A Cetanol 2.0 wt% Vaseline 2.0 Squalane 20.0 Glycerin monofatty acid ester 2.0 Tween 60 3.0 (polyoxyethylene sorbitan monostearate (20EO)) Isopropyl myristate 6. 0 Stearyl glycyrrhetinate 0.5 Glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate 0.05 4-Methoxy-4'-t-butyldibenzoylmethane 0.05 BHT 0.01 Preservative 0.3 Perfume 0.2 B Glycerin 10.0 Propylene glycol 5.0 Arbutin 2.0 Distilled water Residue (Production method) The raw materials of the oil phase part belonging to A and the raw material of the aqueous phase part belonging to B are heated to 70 ° C. to be completely dissolved. After that, the oil phase part is mixed with the water phase part and emulsified by an emulsifying machine. The emulsion is cooled with a heat exchanger to a final temperature of 30 ° C.

Example 11 Pack Phosphate-L-ascorbyl magnesium (APM) 1.0 wt% 2-hydroxy-4-methoxybenzophenone-5-sulfonate 0.05 BHT 0.01 Polyvinyl alcohol 10.0 Polyethylene glycol 3.0 Propylene glycol 7.0 Ethanol 10.0 POE (15) oleyl alcohol ether 0.5 Preservative 0.05 Perfume 0.05 Distilled water Residual (production method) APM, polyethylene glycol in distilled water, 2
-Hydroxy-4-methoxybenzophenone-5-sulfonate and a preservative were added and dissolved with stirring. Next, polyvinyl alcohol was added and dissolved by heating, and BHT and POE (15) oleyl alcohol ether were added to propylene glycol and dissolved by heating. Finally, ethanol in which a fragrance was dissolved was added and dissolved by stirring to obtain a pack.

Example 12 Emulsion A Vaseline 1.0 wt% liquid paraffin 2.0 POE (20) oleic acid 1.0 jojoba oil 1.0 glycerin monooleate 1.0 octyl-p-methoxycinnamate 0.05 4 -Methoxy-4'-t-butyldibenzoylmethane 0.05 BHT 0.01 Preservative 0.2 Perfume 0.1 B Propylene glycol 1.0 Glycerin 2.0 Kojic acid 1.0 Magnesium chloride 0.01 Hyaluronic acid Sodium 0.01 Carboxyvinyl polymer 0.15 Caustic potash 0.05 Distilled water Residue (Production method) The raw materials of the oil phase part belonging to A and the raw materials of the water phase part belonging to B are each heated to 70 ° C. and completely dissolved. The oil phase part is mixed with the water phase part and emulsified by an emulsifying machine. The emulsion is cooled with a heat exchanger to a final temperature of 30 ° C.

Example 13 Cream A Cetanol 2.0% by weight Vaseline 2.0 Squalane 20.0 Glycerin monofatty acid ester 2.0 Monostearate POE (20) Glycerin 3.0 Isopropyl myristate 6.0 Stearyl glycyrrhetinate 0 .5 glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate 0.05 4-methoxy-4'-t-butyldibenzoylmethane 0.05 BHT 0.01 preservative 0.3 perfume 0.2 B glycerin 10.0 Propylene glycol 5.0 Arbutin 2.0 Dipotassium glycyrrhizinate 0.1 Calcium chloride 0.005 Distilled water Residual (manufacturing method) The oil phase raw material belonging to A and the water phase raw material belonging to B are each 70 ° C. After heating and completely dissolving, mix the oil phase part with the water phase part and Te emulsified processing. The emulsion is cooled with a heat exchanger to a final temperature of 30 ° C.

Example 14 Pack Phosphate-L-ascorbyl magnesium (APM) 1.0 wt% 2-hydroxy-4-methoxybenzophenone-5-sulfonate 0.05 BHT 0.01 Polyvinyl alcohol 10.0 Polyethylene glycol 3.0 Propylene glycol 7.0 Calcium hydroxide 0.1 Ethanol 10.0 POE (15) Oleyl alcohol ether 0.5 Preservative 0.05 Perfume 0.05 Distilled water Residual (production method) APM in distilled water, polyethylene glycol Two
-Hydroxy-4-methoxybenzophenone-5-sulfonate and a preservative were added and dissolved with stirring. Next, polyvinyl alcohol was added and dissolved by heating. Further, BHT, POE (15) oleyl alcohol ether and calcium hydroxide were added to propylene glycol and dissolved by heating and mixed. Finally, ethanol in which a fragrance was dissolved was added and dissolved by stirring to obtain a pack.

Example 15 Emulsion A Vaseline 1.0 wt% liquid paraffin 2.0 POE (20) oleic acid 1.0 jojoba oil 1.0 glycerin monooleate 1.0 octyl-p-methoxycinnamate 0.05 4 -Methoxy-4'-t-butyldibenzoylmethane 0.05 BHT 0.01 Preservative 0.2 Perfume 0.1 B Propylene glycol 1.0 Glycerin 2.0 Kojic acid 1.0 Sodium bisulfite 0.1 Hyalurone Sodium acid 0.01 Carboxyvinyl polymer 0.15 Caustic potash 0.05 Distilled water Residue (production method) The raw materials of the oil phase part belonging to A and the raw materials of the water phase part belonging to B are heated to 70 ° C. and completely dissolved. , The oil phase part is mixed with the water phase part and emulsified by an emulsifying machine. The emulsion is cooled with a heat exchanger to a final temperature of 30 ° C.

Example 16 Cream A Cetanol 2.0 wt% Vaseline 2.0 Squalane 20.0 Glycerin monofatty acid ester 2.0 POE (25) cetyl ether 3.0 Isopropyl myristate 6.0 Stearyl glycyrrhetinate 0.5 Glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate 0.05 4-methoxy-4'-t-butyldibenzoylmethane 0.05 BHT 0.01 Preservative 0.3 Perfume 0.2 B Glycerin 10. 0 Propylene glycol 5.0 Arbutin 2.0 Dipotassium glycyrrhizinate 0.1 Sodium sulfite 0.005 Distilled water Residue (manufacturing method) The raw material of the oil phase part belonging to A and the raw material of the aqueous phase part belonging to B are heated to 70 ° C., respectively. Then, after completely dissolving, the oil phase part is mixed with the water phase part and emulsified by an emulsifying machine. To. The emulsion is cooled with a heat exchanger to a final temperature of 30 ° C.

Example 17 Pack Phosphate-L-ascorbyl magnesium (APM) 1.0 wt% 2-hydroxy-4-methoxybenzophenone sodium sulfonate 0.05 BHT 0.01 Polyvinyl alcohol 10.0 Polyethylene glycol 3.0 Propylene glycol 7.0 Sodium pyrosulfite 0.001 Ethanol 10.0 POE (15) oleyl alcohol ether 0.5 Preservative 0.05 Perfume 0.05 Distilled water Residual (production method) APM, polyethylene glycol in distilled water, 2
Sodium 4-hydroxy-4-methoxybenzophenonesulfonate and a preservative were added and dissolved with stirring. Next, polyvinyl alcohol was added and dissolved by heating. Further, BHT, POE (15) oleyl alcohol ether, and sodium pyrosulfite were added to propylene glycol and dissolved by heating. Finally, ethanol in which a fragrance was dissolved was added and dissolved by stirring to obtain a pack.

The external preparations for skin of Examples 9 to 17 were all excellent in light stability.

[0038]

As described above, the external preparation for skin of the present invention stably contains L-ascorbic acid and its derivatives, hydroquinone glycosides and their derivatives, kojic acid and its derivatives, which are whitening agents, in the system. And can prevent discoloration with respect to light.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical indication location A61K 7/00 A61K 7/00 X 7/42 7/42 7/48 7/48 (72) Invention Person Tokue Watari, 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Within Shiseido Daiichi Research Center, Inc. (72) Inventor, Seiji Nishiyama 1050, Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Daiichi Research Center, Inc.

Claims (8)

[Claims] 1. L-ascorbic acid and its derivatives,
A skin external preparation characterized by comprising one or more selected from the group consisting of hydroquinone glycosides and derivatives thereof, kojic acid and derivatives thereof, an ultraviolet absorber and dibutylhydroxytoluene. 2. The external preparation for skin according to claim 1, further comprising a sequestering agent. 3. The external preparation for skin according to claim 1, further comprising a divalent and / or trivalent metal salt. 4. The method according to claim 1, further comprising one or more selected from sulfurous acid and salts thereof, hydrogen sulfite and salts thereof, thiosulfuric acid and salts thereof, pyrosulfurous acid and salts thereof. External skin preparation. 5. L-ascorbic acid and its derivatives,
The amount of one or more selected from the group consisting of hydroquinone glycosides and their derivatives, kojic acid and its derivatives is 0.001 to 15.0% by weight, and the amount of the ultraviolet absorber is 0. 0.01 to 1.0% by weight,
The compounding amount of dibutylhydroxytoluene is 0.0001-
The external preparation for skin according to any one of claims 1 to 4, which is 0.1% by weight. 6. The compounding amount of the sequestering agent is 0.001.
The external preparation for skin according to claim 2, which is about 1.0% by weight. 7. The external preparation for skin according to claim 3, wherein the compounding amount of the divalent and / or trivalent metal salt is 0.0001 to 1.0% by weight. 8. The compounding amount of one or more selected from sulfurous acid and its salt, hydrogen sulfite and its salt, thiosulfuric acid and its salt, pyrosulfurous acid and its salt is 0.00.
The external preparation for skin according to claim 4, which is from 01 to 1.0% by weight.