JP7675585B2 - Vascular Model - Google Patents

Description

The present invention relates to a vascular model that simulates blood vessels.

In recent years, interventions have been performed in which a medical elongated object such as a catheter or guidewire is inserted through the skin into a blood vessel and passed through the blood vessel to reach the desired location. Because interventions are performed through blood vessels that are complexly curved, the catheter is required to be able to reach the desired location. For this reason, for example, Patent Document 1 describes a blood vessel model that is used to test the operability, etc., of a medical elongated object.

JP 2001-343891 A

In prostate artery embolization as a treatment for benign prostatic hyperplasia, and liver artery embolization as a treatment for liver cancer, a microcatheter or guidewire is used to select a thin branch blood vessel that branches off at an acute angle from a thick main blood vessel, which can be difficult to select. In particular, when the main blood vessel is thick, the microcatheter is prone to bending, making it difficult to enter the branch blood vessel, or even if it does enter, the tip of the microcatheter may slip out. Furthermore, when the branch blood vessel forms an acute angle with the main blood vessel, the tip of the microcatheter is likely to slip out of the branch blood vessel, making selection even more difficult.

In prostate arterial embolization, the internal iliac artery, which is the main blood vessel, has an inner diameter of 2-8 mm, and the branch blood vessels have an inner diameter of about 1 mm. In liver arterial embolization, the main blood vessel has an inner diameter of 2-5 mm, and the branch blood vessels have an inner diameter of about 1 mm, and there may be further continuous branches. When the branch blood vessels have further continuous branches, it becomes even more difficult to select the branch blood vessels using a microcatheter or guidewire.

The vascular model described in Patent Document 1 makes it difficult to evaluate the selection performance of medical elongated objects such as microcatheters and guidewires in thin branching blood vessels that branch off at acute angles from the main blood vessel as described above.

In addition, a branched blood vessel may have multiple continuous meandering sections, and it may be necessary to insert a medical elongated object into such a branched blood vessel. However, conventional blood vessel models are not capable of evaluating a branched blood vessel that has such continuous meandering sections.

The present invention has been made to solve the above-mentioned problems, and aims to provide a blood vessel model that can evaluate the selection performance of a medical elongated object for a branched blood vessel having multiple continuous meandering sections.

The blood vessel model of the present invention, which achieves the above-mentioned object, is a blood vessel model that simulates a blood vessel, and has a main passage that simulates a main blood vessel, and a plurality of branch passages that are narrower than the main passage and simulate branch blood vessels branching off from the main blood vessel, the plurality of branch passages branch off in a certain direction from the same main blood vessel, each of the branch passages meanders so as to have three or more peaks that are convex on one side and the other side with respect to the branching direction from the main blood vessel, the plurality of peaks of the same branch passage are bent so as to have the same radius of curvature, and the peaks of the plurality of branch passages each have a different radius of curvature .

The blood vessel model constructed as described above can be used to evaluate the selectivity of the medical elongated object to a branch blood vessel having multiple continuous meandering sections. The blood vessel model can also evaluate the degree of passability of the medical elongated object through multiple paths with different radii of curvature.

The main passage may have a bend between the entrance and the branch passage closest to the entrance. This allows the medical elongated object to enter the branch passage while a bending load is applied, making it possible to evaluate the performance under conditions close to those found inside an actual living body.

It may also have a second main passageway with a meandering section that is convex on one side and the other side, and a straight bypass passageway that opens into and communicates with the inlet and outlet sides of the second main passageway. This allows the performance of the medical elongated body to be evaluated by arbitrarily combining meandering passageways and straight passageways.

The device may have a third main passage having a curved section that bends in one direction, an inner circumference side branch passage that branches toward the inner circumference side of the curved section, and an outer circumference side branch passage that branches toward the outer circumference side of the curved section. This makes it possible to evaluate the difference in torque required to advance the medical elongated object from the passage that bends in one direction into the passages that branch toward the inner circumference side and the outer circumference side, respectively.

The inner circumference side branch passage and the outer circumference side branch passage may each be configured to meander so as to have a convex mountain portion on one side and the other side in the branching direction from the curved portion. This makes it possible to evaluate the passability of the medical elongated body when the passages branching from the curved portion to the inner circumference side and the outer circumference side, respectively, are meandering.

FIG. 2 is a plan view showing a blood vessel model according to the embodiment. FIG. 2 is a side view showing a blood vessel model according to the embodiment. FIG. 2 is an enlarged view of the first main passage and the branch passage in FIG. 1 , showing a state in which a medical elongated object has been inserted into the first branch passage; FIG. 2 is an enlarged view of the vicinity of the second main passage in FIG. 1, showing a state in which an elongated medical object has been inserted into the second main passage; 2 is an enlarged view of the vicinity of the third main passage, the inner peripheral branch passage, and the outer peripheral branch passage in FIG. 1, showing a state in which a medical elongated object has entered the inner peripheral branch passage; FIG.

The following describes an embodiment of the present invention with reference to the drawings. Note that the dimensions in the drawings may be exaggerated for the sake of explanation and may differ from the actual dimensions. In addition, in this specification and the drawings, components having substantially the same functions are designated by the same reference numerals to avoid redundant explanation.

The vascular model 10 according to this embodiment is a model that simulates a blood vessel in order to evaluate the selectivity of branched blood vessels of a medical elongated body such as a microcatheter or a guidewire. Note that the use of the vascular model 10 is not limited to the use for evaluating a medical elongated body, and may be used, for example, for training in procedures.

1 and 2, the blood vessel model 10 includes two split simulation parts 11, two holding plates 12 sandwiching the split simulation parts 11, a plurality of connectors 13, and an insertion port 14. The two split simulation parts 11 are substantially rectangular flat plates with grooves simulating blood vessels formed on the opposing surfaces 15. The two split simulation parts 11 are formed in a plane-symmetrical shape. Therefore, by overlapping on the opposing surfaces 15, the grooves overlap to form a blood vessel simulation part 20 simulating a blood vessel with a substantially circular cross section. The split simulation part 11 is preferably transparent or semi-transparent so that the inside can be visually observed, and is preferably formed from a flexible material similar to actual biological tissue. The constituent material of the split simulation part 11 is not particularly limited, but may be, for example, silicone resin, various elastomer resins such as SEBS, polyolefin elastomer, polyamide elastomer, acrylic elastomer, and fluorine-containing elastomer. In this embodiment, the constituent material of the split simulation part 11 is silicone resin. The divided simulation portion 11 is preferably formed using a mold, but the formation method is not particularly limited and may be formed, for example, using a 3D printer.

The holding plate 12 is a member that sandwiches the two flexible split simulation parts 11 in order to hold the two flexible split simulation parts 11 in an overlapping state. Each holding plate 12 is a substantially rectangular flat plate that can cover the split simulation part 11. The holding plate 12 is preferably transparent or semi-transparent so that the inside can be visually observed, and is formed from a hard material that can hold the flexible split simulation part 11. The material of the holding plate 12 is not particularly limited, but may be, for example, acrylic resin, ABS resin, acrylic resin, methacrylic resin, polycarbonate, melamine resin, styrene resin, hard polyvinyl chloride resin, fluororesin, glass, etc. In this embodiment, the material of the holding plate 12 is acrylic resin.

The connector 13 is a member for holding the split simulation part 11 sandwiched between the holding plates 12. The connector 13 is, for example, composed of a bolt and a nut that can pass through through holes formed in the split simulation part 11 and the holding plates 12 and hold the two holding plates 12 together. The configuration of the connector 13 is not particularly limited, and may be, for example, a clamp.

The insertion port 14 is a portion through which the medical elongated body is inserted into the blood vessel model 10. The insertion port 14 is arranged on the side end faces of the two divided simulation sections 11 in communication with the grooves so as to be sandwiched between the opposing grooves. The insertion port 14 is, for example, configured with a hemostatic valve having a three-way stopcock or a Y connector, and is connected to a communication passage 21 of the blood vessel simulation section 20, which will be described later, as a portion through which the medical elongated body is inserted. The insertion port 14 equipped with a hemostatic valve or the like may also be arranged on an opening other than the communication passage 21 on the side end faces of the two divided simulation sections 11. This makes it easier to fill the inside of the blood vessel simulation section 20 with liquid, and the state of being filled with liquid can be maintained well.

The blood vessel model 10 is a model having a substantially planar structure. The thickness of the blood vessel model 10 having a substantially planar structure is 100 mm or less, preferably 50 mm or less, and more preferably 30 mm or less.

Next, the blood vessel simulation section 20 formed in the divided simulation section 11 will be described in detail. First, the lower half of the blood vessel simulation section 20 will be described. As shown in FIG. 1, the blood vessel simulation section 20 includes a communication passage 21 to which the insertion port 14 is connected, a main passage 30 that simulates the main blood vessel, a plurality of branch passages 40 that simulate branch blood vessels branching off from the main blood vessel, and an auxiliary passage 50 for removing air when filling the blood vessel simulation section 20 with liquid.

The main passage 30 has a first main passage 31 extending from the communication passage 21. As shown in FIG. 3, the first main passage 31 has a large-diameter linear large-diameter passage section 31a that communicates with the communication passage 21, a bent passage section 31b that bends in an S-shape at the distal side of the large-diameter passage section 31a, a straight passage section 31c that communicates with the distal side of the bent passage section 31b and extends between the communication passage 21 and the end of the blood vessel simulation section 20, and an introduction passage section 31d that branches off from the straight passage section 31c and bends in an L-shape. The distal side means the side of the passage that is away from the insertion port 14 (the side in the direction of travel of the medical elongated body to be inserted).

The first main passage 31 extends from the inlet of the communication passage 21 toward the peripheral side in the order of the large diameter passage section 31a, the bent passage section 31b, the straight passage section 31c, and the introduction passage section 31d, and has a bent section 31e that bends multiple times. The introduction passage section 31d has three branch passages 40 that branch in a certain direction. The branch passages 40 have the first branch passage 41, the second branch passage 42, and the third branch passage 43 along the inlet side to the peripheral side. The first branch passage 41, the second branch passage 42, and the third branch passage 43 each have three or more peaks 41a, 41b, and 41c that are convex on one side and the other side with respect to the branching direction from the introduction passage section 31d, which is the main passage 30. The first branch passage 41, the second branch passage 42, and the third branch passage 43 are all connected to the auxiliary passage 50 on the peripheral side.

The multiple peaks 41a of the first branch passage 41 are all bent to have the same radius of curvature. The multiple peaks 42a of the second branch passage 42 are all bent to have the same radius of curvature. The multiple peaks 43a of the third branch passage 43 are all bent to have the same radius of curvature. Furthermore, the peaks 41a of the first branch passage 41 have a larger radius of curvature than the peaks 42a of the second branch passage 42, and the peaks 42a of the second branch passage 42 have a larger radius of curvature than the peaks 43a of the third branch passage 43. That is, the peaks 41a, 42a, 43a of each branch passage have different radii of curvature.

The first branch passage 41, the second branch passage 42, and the third branch passage 43 all branch off from the straight portion of the introduction passage portion 31d. Therefore, the bent portion 31e of the first main passage 31 is disposed between the communication passage 21, which is the inlet of the first main passage 31, and the first branch passage 41 that is closest to the communication passage 21.

The diameters of the passages are, for example, as follows: large diameter passage section 31a is 8 mm, curved passage section 31b is 6 mm, straight passage section 32c is 5 mm, introduction passage section 31c is 3 mm, first branch passage 41 is 2.5 mm, second branch passage 42 is 2 mm, and third branch passage 43 is 1.5 mm. The radius of curvature of peak 41a of first branch passage 41 is 5 mm, the radius of curvature of peak 42a of second branch passage 42 is 4 mm, and the radius of curvature of peak 43a of third branch passage 43 is 3 mm.

As shown in FIG. 4, the main passage 30 has a second main passage 32 extending from the large diameter passage section 31a and the bent passage section 31b of the first main passage 31. The second main passage 32 has a first serpentine passage section 32a communicating with the large diameter passage section 31a, a straight passage section 32c communicating with the first serpentine passage section 32a, and a second serpentine passage section 32b communicating with the straight passage section 32c. The first serpentine passage section 32a branches off from the bent passage section 31b at an angle of less than 90°. The second serpentine passage section 32b branches off from the straight passage section 32c at an angle of less than 90°. The second main passage 32 has a first bypass passage 32d that linearly connects the large diameter passage 31a and the distal side of the first serpentine passage 32a, and a second bypass passage 32e that linearly connects the inlet side and the distal side of the second serpentine passage 32b. The first bypass passage 32d opens to the inlet side of the second main passage 32, and the second bypass passage 32e opens to the outlet side of the second main passage 32.

The diameter of each passage is, for example, as follows: the first serpentine passage section 32a is 3 to 5 mm, the straight passage section 32c is 3 to 4 mm, the second serpentine passage section 32b is 3 mm, the first bypass passage section 32d is 4 mm, and the second bypass passage section 32e is 3 mm.

As shown in FIG. 5, the main passage 30 has a third main passage 33 extending from the distal end of the second main passage 32. The third main passage 33 has a curved portion 33a that bends clockwise in a front view from the distal end of the second main passage 32 toward the distal side. From the curved portion 33a, an inner circumference side branch passage 44 branches toward the inner circumference side, and an outer circumference side branch passage 45 branches toward the outer circumference side.

The inner branch passage 44 has multiple peaks 44a that are convex on one side and on the other side in the branching direction from the curved section 33a. The outer branch passage 45 has multiple peaks 45a that are convex on one side and on the other side in the branching direction from the curved section 33a.

The diameter of each passage is, for example, as follows: the curved portion 33a is 3 mm, and the inner circumference side branch passage 44 and the outer circumference side branch passage 45 are 2 mm. The radius of curvature of the peak portion 44a of the inner circumference side branch passage 44 and the peak portion 45a of the outer circumference side branch passage 45 is 2.75 mm.

Next, the upper half of the blood vessel simulation section 20 will be described. As shown in FIG. 1, the upper half of the blood vessel simulation section 20 also has a main passage 60 and a branch passage 70. The main passage 60 has a fourth main passage 61 extending from the communication passage 21, and a fifth main passage 62 branching from the fourth main passage 61. The fourth main passage 61 extends linearly from the communication passage 21.

The fifth main passage 62 is a passage that branches off from the fourth main passage 61 at a predetermined branching angle. The fifth main passage 62 extends linearly from the fourth main passage 61.

The fourth main passage 61 and the fifth main passage 62 are connected to a number of branch passages 70 that are arranged in the extension direction of the main passage 60 and branch off from the main passage 60 at different branching angles.

Next, we will explain a method for evaluating a medical elongated object using the vascular model 10 according to this embodiment.

First, the tester performing the evaluation test determines the main passage 30 and the branch passage 40 into which the medical elongated body is to be inserted. For example, the tester determines to insert the medical elongated body 100 from the first main passage 31 into the first branch passage 41, as shown in FIG. 3. In this example, the medical elongated body 100 is a guidewire.

The tester injects water, saline, an aqueous solution containing a surfactant, or the like into the blood vessel model 10 through the insertion port 14. This causes water, saline, an aqueous solution containing a surfactant, or the like to flow into the inside of the blood vessel simulation part 20 of the blood vessel model 10. The air inside the blood vessel model 10 is discharged to the outside through an opening formed on the side end face of the blood vessel simulation part 20, the auxiliary passage 50, or the like. This causes the inside of the blood vessel simulation part 20 of the blood vessel model 10 to be filled with water, saline, an aqueous solution containing a surfactant, or the like. Alternatively, a surfactant or a lubricating polymer may be applied in advance to the inner surface of the blood vessel simulation part 20, or a hydrophilic lubricating polymer containing acrylamide or a hydrophobic lubricating polymer such as a fluororesin may be applied as the lubricating polymer.

Next, the tester inserts the medical elongated body 100 through the insertion port 14 that communicates with the communication passage 21, and allows the tip to reach the large diameter passage section 31a of the first main passage 31. Next, the tester moves the tip of the medical elongated body 100 from the large diameter passage section 31a through the bent passage section 31b and the straight passage section 31c, and into the introduction passage section 31d. Because the passage is bent in an S-shape from the bent passage section 31b to the introduction passage section 31d, a bending load can be applied to the medical elongated body 100 when the medical elongated body 100 is introduced into the branch passage 40. This allows the medical elongated body 100 to be tested under conditions close to those in an actual living body.

Then, the tester selects the first branch passage 41 with the tip of the medical elongated body 100 and attempts to push the medical elongated body 100 into the first branch passage 41. This allows the tester to evaluate, using the blood vessel model 10, whether or not the medical elongated body 100 has been able to select the first branch passage 41 from the first main passage 31.

In addition to the first branch passage 41, the branch passage 40 has a second branch passage 42 and a third branch passage 43, so the tester can select any one of these branch passages 40. The crest 42a of the second branch passage 42 has a smaller radius of curvature than the crest 41a of the first branch passage 41, so it is more difficult to pass the medical elongated body 100 through it. In addition, the crest 43a of the third branch passage 43 has a smaller radius of curvature than the crest 42a of the second branch passage 42, so it is even more difficult to pass the medical elongated body 100 through it. The tester can evaluate the passability of the medical elongated body 100 through the meandering section by sequentially selecting the first branch passage 41, the second branch passage 42, and the third branch passage 43 and attempting to enter the medical elongated body 100. In addition, because the medical elongated body 100 already meanders in the first main passage 31 before the branch passage 40, it is possible to appropriately evaluate the passability when entering a meandering branch blood vessel from a meandering main blood vessel.

Next, a case where the tester selects the second main passage 32 will be described. In this example, the medical elongated body 100 is a catheter. As shown in FIG. 4, the tester inserts a guiding catheter (not shown) from the insertion port 14 that communicates with the communication passage 21, and reaches the tip of the guiding catheter into the large diameter passage portion 31a of the first main passage 31, and inserts the medical elongated body 100 into it, and reaches it from the communication passage 21 to the entrance of the first serpentine passage portion 32a.

Next, the tester attempts to move the tip of the medical elongated body 100 from the first serpentine passage section 32a to the straight passage section 32c. After moving the tip of the medical elongated body 100 to the distal side of the straight passage section 32c, the tester attempts to move the tip of the medical elongated body 100 to the second serpentine passage section 32b. This allows the passability of the medical elongated body 100 to be evaluated for a pattern that combines serpentine and straight sections.

If the medical elongated body 100 buckles in the first serpentine passage section 32a and entry is difficult, the tester may attempt to guide the medical elongated body 100 from the large diameter passage section 31a through the first bypass passage section 32d to the straight passage section 32c, and then enter the medical elongated body 100 from the straight passage section 32c into the second serpentine passage section 32b. In this way, the combination of serpentine and straight sections may be changed according to the needs of the test and the skill of the tester, allowing for flexible testing.

Next, a case where the tester selects the third main passage 33 will be described. In this example, the medical elongated body 100 is a catheter. In this case, either the inner circumference side branch passage 44 or the outer circumference side branch passage 45 branching off from the third main passage 33 can be selected. In this example, it is assumed that the tester selects the inner circumference side branch passage 44. The tester inserts a guiding catheter (not shown) from the insertion port 14 communicating with the communication passage 21, and reaches the tip of the large diameter passage portion 31a of the first main passage 31, and inserts the medical elongated body 100 into it, and reaches the entrance of the third main passage 33 through the communication passage 21, the first bypass passage portion 32d, the straight passage portion 32c, and the second bypass passage portion 32e.

As shown in FIG. 5, the tester attempts to insert the tip of the medical elongated body 100 from the curved portion 33a of the third main passage 33 into the inner circumference side branch passage 44. The inner circumference side branch passage 44 is formed in a serpentine shape with multiple peaks 44a, so the tester can evaluate the passability of the path that bends from the curved portion 33a, which bends in one direction, to the inner circumference side and then becomes serpentine.

When the tester selects the outer periphery branch passage 45, the tester attempts to enter the tip of the medical elongated body 100 from the curved portion 33a of the third main passage 33 into the outer periphery branch passage 45. Since the outer periphery branch passage 45 is formed in a serpentine shape with multiple peaks 45a, the tester can evaluate the passability of the path that bends from the curved portion 33a, which bends in one direction, to the outer periphery and then ends in a serpentine shape.

When the medical elongated body 100 passes through the branch from the curved section 33a that bends in one direction, the torque required differs between the inner circumference side and the outer circumference side. Therefore, by being able to evaluate both the inner circumference side branch passage 44 and the outer circumference side branch passage 45, it is possible to carry out an appropriate evaluation of the medical elongated body 100.

The evaluation method for medical elongated objects may also be performed on a combination of a catheter and a guidewire.

The blood vessel model 10 may also be used upside down. For this reason, the large diameter passage portion 31a simulating the aorta is formed to be symmetrical up and down. In addition, assuming that the liver is on the left side as seen by the tester, the medical elongated body 100 can be inserted from any of the insertion ports 14 connected to the communication passage 21. In the state of FIG. 1, when the medical elongated body 100 is inserted from the upper insertion port 14, a radial approach is simulated, and when the medical elongated body 100 is inserted from the lower insertion port 14, a femoral approach is simulated. Alternatively, the blood vessel model 10 may be used upside down. For example, even when the medical elongated body 100 is inserted from the upper insertion port 14 to simulate a radial approach, by inverting the blood vessel model 10 upside down in advance, the insertion angle of the medical elongated body 100 relative to the auxiliary passage 50, for example, changes, so that the blood vessel branching angle, which varies among individuals in actual clinical practice, can be simulated.

As described above, the blood vessel model 10 according to this embodiment is a blood vessel model 10 that simulates a blood vessel, and has a main passage 30 that simulates a main blood vessel, and a plurality of branch passages 40 that are narrower than the main passage 30 and simulate branch blood vessels branching from the main blood vessel 30. The plurality of branch passages 40 branch off in a certain direction from the same main blood vessel 30, and each branch passage 40 meanders to have three or more peaks 41a that are convex on one side and the other side with respect to the branching direction from the main blood vessel 30. The blood vessel model 10 configured in this manner can evaluate the selection performance of the medical elongated body 100 to a branch blood vessel having a plurality of continuous meandering portions.

In addition, the multiple peaks 41a of the same branch passage 40 may be bent to have the same radius of curvature, and the multiple branch passages 40 may have peaks 41a, 42a, and 43a each having a different radius of curvature. This allows the degree of passability of the medical elongated body 100 to be evaluated using multiple paths with different radii of curvature.

The main passage 30 may also have a bend 31e between the entrance and the branch passage 41 closest to the entrance. This allows the medical elongated object to enter the branch passage 41 while a bending load is applied, making it possible to evaluate performance under conditions close to those found inside an actual living body.

In addition, the second main passage 32 may have a serpentine portion that is convex on one side and the other side, and linear bypass passages 32d, 32e that open to and communicate with the inlet and outlet sides of the second main passage 32, respectively. This allows the performance of the medical elongated body 100 to be evaluated by arbitrarily combining serpentine passages and linear passages.

Also, the third main passage 33 may have a curved section 33a that bends in one direction, an inner circumference side branch passage 44 that branches toward the inner circumference side of the curved section 33a, and an outer circumference side branch passage 45 that branches toward the outer circumference side of the curved section 33a. This makes it possible to evaluate the difference in torque required to advance the medical elongated body 100 from the passage that bends in one direction into the passages that branch toward the inner circumference side and the outer circumference side, respectively.

The inner circumference side branch passage 44 and the outer circumference side branch passage 45 may be made to meander so as to have peaks 44a, 45a that are convex on one side and the other side in the branching direction from the curved portion 33a. This makes it possible to evaluate the passability of the medical elongated body 100 when the passages branching from the curved portion 33a to the inner circumference side and the outer circumference side, respectively, are meandering.

The present invention is not limited to the above-described embodiment, and various modifications may be made by those skilled in the art within the technical concept of the present invention. In the blood vessel model 10, the arrangement, diameter, curvature radius, etc. of each branch passage can be set arbitrarily as necessary. In addition, the direction in which the branch passages face may be inverted upside down.

REFERENCE SIGNS LIST 10 Blood vessel model 11 Divided simulated portion 12 Holding plate 13 Connector 14 Insertion port 15 Opposing surface 20 Blood vessel simulated portion 21 Communication passage 30 Main passage 31 First main passage 31a Large diameter passage portion 31b Bent passage portion 31c Straight passage portion 31d Introduction passage portion 31e Bent portion 32 Second main passage 32a First meandering passage portion 32b Second meandering passage portion 32c Straight passage portion 32d First bypass passage portion 32e Second bypass passage portion 33 Third main passage 33a Curved portion 40 Branch passage 41 First branch passage 41a Ridge portion 42 Second branch passage 42a Ridge portion 43 Third branch passage 43a Ridge portion 44 Inner circumference side branch passage 44a Ridge portion 45 Outer circumference side branch passage 45a: mountain portion 50: auxiliary passage 100: long medical body

Claims (5)

A blood vessel model simulating a blood vessel,
The device has a main passageway simulating a main blood vessel, and a plurality of branch passageways simulating branch blood vessels branching from the main blood vessel and narrower than the main passageway,
The plurality of branch passages branch off from the same main passage in a certain direction,
each of the branch passages meanders to have three or more peaks that are convex on one side and on the other side with respect to a branching direction from the main passage ;
the plurality of peaks of the same branch passage are bent to have the same radius of curvature,
The blood vessel model has a plurality of branch passages, each of whose peaks has a different radius of curvature . 2. The blood vessel model according to claim 1 , wherein the main passage has a bend between an inlet and the branch passage closest to the inlet. a second main passage having a meandering portion that is convex on one side and a meandering portion on the other side;
3. The blood vessel model according to claim 1, further comprising a linear bypass passage that opens to and communicates with an inlet side and an outlet side of the second main passage, respectively. a third main passage having a curved portion that bends in one direction;
an inner periphery side branch passage branching toward an inner periphery side of the curved portion;
The blood vessel model according to claim 1 , further comprising: an outer periphery branch passage that branches out toward an outer periphery of the curved portion. 5. The blood vessel model according to claim 4 , wherein the inner circumference side branch passage and the outer circumference side branch passage are meandering so as to have convex mountain portions on one side and the other side in a branching direction from the curved portion.

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