JP7435995B2 - Method for producing lamellar liquid crystal emulsion composition - Google Patents
Method for producing lamellar liquid crystal emulsion composition Download PDFInfo
- Publication number
- JP7435995B2 JP7435995B2 JP2019114170A JP2019114170A JP7435995B2 JP 7435995 B2 JP7435995 B2 JP 7435995B2 JP 2019114170 A JP2019114170 A JP 2019114170A JP 2019114170 A JP2019114170 A JP 2019114170A JP 7435995 B2 JP7435995 B2 JP 7435995B2
- Authority
- JP
- Japan
- Prior art keywords
- liquid crystal
- emulsion composition
- group
- mass
- lamellar liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 91
- 239000004973 liquid crystal related substance Substances 0.000 title claims description 77
- 239000000839 emulsion Substances 0.000 title claims description 61
- 238000004519 manufacturing process Methods 0.000 title claims description 20
- -1 isostearyl group Chemical group 0.000 claims description 39
- 239000004094 surface-active agent Substances 0.000 claims description 31
- 238000002156 mixing Methods 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 15
- 150000005846 sugar alcohols Polymers 0.000 claims description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 8
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- 235000011187 glycerol Nutrition 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 6
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 claims description 5
- 229940105990 diglycerin Drugs 0.000 claims description 5
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 5
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- 238000009472 formulation Methods 0.000 claims description 5
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
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- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 239000001294 propane Substances 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
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- 238000000034 method Methods 0.000 description 8
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 5
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
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- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- BFZNCPXNOGIELB-UHFFFAOYSA-N propan-2-yl 10-[5,6-dihexyl-2-(8-oxo-8-propan-2-yloxyoctyl)cyclohex-3-en-1-yl]dec-9-enoate Chemical compound CCCCCCC1C=CC(CCCCCCCC(=O)OC(C)C)C(C=CCCCCCCCC(=O)OC(C)C)C1CCCCCC BFZNCPXNOGIELB-UHFFFAOYSA-N 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229940010310 propylene glycol dioleate Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
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- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
- 229960003656 ricinoleic acid Drugs 0.000 description 1
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 239000010667 rosehip oil Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
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- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
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- 239000003549 soybean oil Substances 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
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- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
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- 150000003751 zinc Chemical class 0.000 description 1
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Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Description
本発明は、ラメラ型液晶乳化組成物の製造方法に関し、特に、高圧乳化装置や酸化エチレン・酸化プロピレンを付加重合した乳化剤用いずに安定性が向上したラメラ型液晶構造の乳化組成物を製造する製造方法に関する。 The present invention relates to a method for producing a lamellar liquid crystal emulsion composition, and in particular, for producing an emulsion composition having a lamellar liquid crystal structure with improved stability without using a high-pressure emulsifier or an emulsifier made by addition polymerization of ethylene oxide and propylene oxide. Regarding the manufacturing method.
従来から、液晶化技術を用いた組成物は、その構造から皮膚への浸透性がよいなどの特徴があり、化粧品業界を中心に数多くの研究が行われている。 Conventionally, compositions using liquid crystal technology have characteristics such as good permeability into the skin due to their structure, and many studies have been conducted mainly in the cosmetics industry.
リン脂質を使用する方法として、例えば、特許文献１には、（Ａ）ホスファチジルコリンの含有量が５０質量％以上である水素添加リン脂質および水溶性多価アルコールとを主成分として含むゲル状混合物と、（Ｂ）ポリエチレングリコールの重合度が８０～１２０であるモノステアリン酸ポリエチレングリコールとを含み、平均乳化粒子径が１０μｍ以下であることを特徴とする水中油型乳化化粧料が、開示されている。また、特許文献２には、次の成分（ａ）、（ｂ）及び（ｃ）、（ａ）リン脂質、糖脂質又はスフィンゴ脂質の一種又は二種以上０．０１～４重量％、（ｂ）ステロール類０．０１～２重量％、（ｃ）高分子電解質０．０００１～０．０５重量％、多糖類生薬抽出物０．０００１～０．０５重量％又は低分子化合物０．０００１～１０重量％の一種又は二種以上、を含有する液晶組成物が、開示されている。 As a method of using phospholipids, for example, Patent Document 1 discloses that (A) a gel-like mixture containing as main components a hydrogenated phospholipid having a phosphatidylcholine content of 50% by mass or more and a water-soluble polyhydric alcohol; , (B) an oil-in-water emulsion cosmetic comprising polyethylene glycol monostearate having a degree of polymerization of polyethylene glycol of 80 to 120, and having an average emulsion particle size of 10 μm or less. . Furthermore, Patent Document 2 describes the following components (a), (b), and (c), (a) 0.01 to 4% by weight of one or more of phospholipids, glycolipids, or sphingolipids; ) 0.01-2% by weight of sterols, (c) 0.0001-0.05% by weight of polyelectrolytes, 0.0001-0.05% by weight of polysaccharide crude drug extracts, or 0.0001-10% by weight of low molecular weight compounds. Liquid crystal compositions are disclosed that contain one or more of the following:
また、ベタイン型両性界面活性剤を使用する方法として、例えば、特許文献３には、下記（Ａ）、（Ｂ）、（Ｃ）及び（Ｄ）成分で、（Ａ）炭素数８～２６の高級脂肪酸塩１５～４５質量％、（Ｂ）ベタイン型両性界面活性剤７～２５質量％、（Ｃ）非イオン性界面活性剤１～５質量％で、非イオン性界面活性剤が、ポリオキシエチレン（エチレンオキサイドの平均付加モル数１０～８０）グリセリル、グリセリン、又はポリオキシエチレン（エチレンオキサイドの平均付加モル数１０～８０）トリメチロールプロパンの３つの水酸基が、エステル化又はエーテル化された化合物であって、エステル化又はエーテル化部分は、炭素数７～２５の飽和又は不飽和、直鎖又は分岐鎖の一価炭化水素基であり、水素原子の一部が水酸基で置換されていてもよく、この水酸基に平均付加モル数が１０～８０のポリオキシエチレンが付加されていてもよい、ただし、非イオン性界面活性剤に付加されるポリオキシエチレンの総数は、平均付加モル数で１０～８０であり、（Ｄ）多価アルコール１５～３５質量％を含有し、２５℃において液晶状態であることを特徴とする皮膚洗浄剤組成物が、開示されている。さらに、高級アルコールを使用する方法として、例えば、特許文献４には、（Ａ）炭素数１６以上の高級アルコール１種または２種以上と、ポリオキシエチレンアルキルエーテル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、及びポリオキシエチレン脂肪酸グリセリルから選択される１種又は２種以上のＨＬＢ値が７～１７のである非イオン性界面活性剤が、３：２～５：１のモル比で混合された混合物、２０～８０質量％、及び、（Ｂ）ＩＯＢ値が１．５～３．５である水溶性溶媒１種または２種以上と、水が、４：６～８：２の質量比で混合された混合物、２０～８０質量％、からなり、５０－８０℃では、両連続マイクロエマルション相又はラメラ液晶が分散した両連続マイクロエマルション相からなる液体であり、室温では固体であること、を特徴とするαゲル中間体組成物が、開示されている。 Further, as a method of using a betaine type amphoteric surfactant, for example, Patent Document 3 describes the following components (A), (B), (C) and (D), (A) having 8 to 26 carbon atoms. 15 to 45% by mass of higher fatty acid salt, (B) 7 to 25% by mass of betaine type amphoteric surfactant, and 1 to 5% by mass of (C) nonionic surfactant. A compound in which the three hydroxyl groups of ethylene (average number of added moles of ethylene oxide 10 to 80) glyceryl, glycerin, or polyoxyethylene (average number of added moles of ethylene oxide 10 to 80) trimethylolpropane are esterified or etherified The esterification or etherification moiety is a saturated or unsaturated, linear or branched monovalent hydrocarbon group having 7 to 25 carbon atoms, even if some of the hydrogen atoms are substituted with hydroxyl groups. Often, polyoxyethylene having an average number of added moles of 10 to 80 may be added to this hydroxyl group, however, the total number of polyoxyethylenes added to the nonionic surfactant is 10 to 10 in terms of the average number of added moles. -80, contains (D) polyhydric alcohol 15-35% by mass, and is in a liquid crystal state at 25°C. Further, as a method of using higher alcohols, for example, Patent Document 4 describes (A) one or more higher alcohols having 16 or more carbon atoms, polyoxyethylene alkyl ether, polyethylene glycol fatty acid ester, polyoxyethylene One or more nonionic surfactants having an HLB value of 7 to 17 selected from hydrogenated castor oil and polyoxyethylene fatty acid glyceryl are mixed at a molar ratio of 3:2 to 5:1. and (B) one or more water-soluble solvents having an IOB value of 1.5 to 3.5 and water in a mass ratio of 4:6 to 8:2. 20 to 80% by mass of a mixture of 20 to 80% by mass, and at 50 to 80 ° C., it is a liquid consisting of a bicontinuous microemulsion phase or a bicontinuous microemulsion phase in which lamellar liquid crystals are dispersed, and is solid at room temperature; An alpha gel intermediate composition is disclosed.
また、ラメラ型液晶を製造する技術として、例えば、特許文献５には、（１）ポリオキシエチレン・ポリオキシプロピレン・アルキルエーテルの一般式、ＨＯ（Ｃ２Ｈ４Ｏ）ｎ－（Ｃ３Ｈ６Ｏ）ｍＲにおいて、ｎ＝１５～５０、ｍ＝４～１６、Ｒはアルキル基で炭素数がＣ１２～Ｃ２４より選ばれたＨＬＢ１０～２０の親水性界面活性剤（ａ）３～６重量部に、ポリオキシエチレン脂肪酸誘導体よりなり、且つポリオキシエチレン（Ｃ２Ｈ４Ｏ）ｎ、ｎ＝１５～５０、アルキル基の炭素数Ｃ１５～Ｃ２４、より選ばれたＨＬＢ１３以上の親水性界面活性剤（ｂ）の１種類又は２種類以上を３～６重量部を配合して得られた配合物に、（２）親油性界面活性剤（ｃ）２～５重量部を配合して得られた配合物８～１７重量部に、（３）油分（ｄ）５～２６重量部を混合して予め得られた配合物に対して、（４）水溶性多価アルコール（ｅ）４０～８０重量部と水（ｆ）８～４０重量部との混合物を加えて、（５）加熱し均一に混合して、（６）冷却することを特徴とする液晶乳化組成物の製造方法が、開示されている。さらに、特許文献６には、（１）下記一般式、一般式 ＨＯ（Ｃ２Ｈ４Ｏ）ｎ－（Ｃ３Ｈ６Ｏ）ｍＲ（式中、ｎは１５～５０、ｍは４～１６の整数、Ｒは、アルキル基で炭素数がＣ１２～Ｃ２４により選ばれる。）、のポリオキシエチレン・ポリオキシプロピレン・アルキルエーテルで、且つＨＬＢ１０～２０の親水性界面活性剤（ａ）３～８重量部と親油性界面活性剤（ｂ）２～６重量部とからなる混合物５～１４重量部に、（２）油分（Ｃ）５～３０重量部で、かつ油分：界面活性剤合計（(a)＋（ｂ））の混合比が１：１～３：１の範囲に混合して得られた混合物に対して、（３）水溶性多価アルコール（ｄ）４０～８０重量部を水（ｅ）８～４０重量部に混合して得られた混合物を加えて加熱し、均一に混合して、冷却することを特徴とする液晶構造を有する液晶乳化組成物の製造方法が、開示されている。 Further, as a technique for manufacturing a lamellar liquid crystal, for example, Patent Document 5 describes (1) the general formula of polyoxyethylene polyoxypropylene alkyl ether, HO(C 2 H 4 O) n -(C 3 H 6 O) m In R, n = 15 to 50, m = 4 to 16, R is an alkyl group, and a hydrophilic surfactant with an HLB of 10 to 20 selected from C 12 to C 24 (a) 3 to 6 parts by weight, polyoxyethylene (C 2 H 4 O) n, n = 15 to 50, an alkyl group having a carbon number of C 15 to C 24 , and an HLB of 13 or more selected from a polyoxyethylene fatty acid derivative; Adding 2 to 5 parts by weight of (2) lipophilic surfactant (c) to a mixture obtained by blending 3 to 6 parts by weight of one or more types of hydrophilic surfactant (b) (4) Water-soluble polyhydric alcohol (e ) 40 to 80 parts by weight of water (f) and 8 to 40 parts by weight of water (f) are added, (5) heated and mixed uniformly, and (6) produced a liquid crystal emulsion composition characterized by cooling. A method is disclosed. Further, Patent Document 6 describes (1) the following general formula, the general formula HO(C 2 H 4 O) n -(C 3 H 6 O) m R (where n is 15 to 50, m is 4 to 16 integer, R is an alkyl group and the number of carbon atoms is selected from C 12 to C 24 ), and a hydrophilic surfactant (a) with an HLB of 10 to 20. To 5 to 14 parts by weight of a mixture consisting of 3 to 8 parts by weight and 2 to 6 parts by weight of lipophilic surfactant (b), (2) 5 to 30 parts by weight of oil (C), and oil: surfactant. For the mixture obtained by mixing the total ((a) + (b)) at a mixing ratio of 1:1 to 3:1, (3) water-soluble polyhydric alcohol (d) 40 to 80% by weight A method for producing a liquid crystal emulsion composition having a liquid crystal structure, characterized in that the mixture obtained by mixing 1 part with 8 to 40 parts by weight of water (e) is added, heated, mixed uniformly, and cooled. , has been disclosed.
しかしながら、特許文献１～３に記載されている技術は、液晶組成物を製造することはできるものの、ラメラ型の液晶を製造することはできるものではなかった。 However, although the techniques described in Patent Documents 1 to 3 can produce liquid crystal compositions, they cannot produce lamellar liquid crystals.
さらに、特許文献４に記載されている技術は、ラメラ型の液晶を製造することはできるものの、安定性に優れたラメラ型液晶構造の乳化組成物を製造するためには高圧乳化装置等が必要であり、通常の撹拌では安定性に優れたラメラ型液晶構造の乳化組成物を製造できるものではなかった。また、特許文献５および６に記載されている技術は、塩による影響を考慮しておらず、ラメラ型液晶構造の乳化組成物の安定性には改良の余地があるものであった。 Furthermore, although the technology described in Patent Document 4 can produce a lamellar liquid crystal, a high-pressure emulsifying device or the like is required to produce an emulsion composition with a highly stable lamellar liquid crystal structure. Therefore, it has not been possible to produce an emulsion composition having a lamellar liquid crystal structure with excellent stability by ordinary stirring. Further, the techniques described in Patent Documents 5 and 6 do not take into account the influence of salt, and there is room for improvement in the stability of emulsion compositions having a lamellar liquid crystal structure.
そこで、本発明の目的は、前記の従来技術の問題点を解決し、高圧乳化装置や酸化エチレン・酸化プロピレンを付加重合した乳化剤用いずに安定性が向上したラメラ型液晶構造の乳化組成物を製造する製造方法を提供することにある。 Therefore, an object of the present invention is to solve the problems of the prior art described above, and to provide an emulsion composition with a lamellar liquid crystal structure that has improved stability without using a high-pressure emulsifier or an emulsifier made by addition polymerization of ethylene oxide and propylene oxide. The purpose is to provide a manufacturing method for manufacturing.
本発明者らは、前記課題を解決すべく鋭意検討を行った結果、特定の種類の界面活性剤を組合せ、さらに塩を配合することによって、前記目的を達成し得ることを見出し、本発明を完成するに至った。 The present inventors have conducted extensive studies to solve the above problems, and have discovered that the above objects can be achieved by combining specific types of surfactants and further adding salt, and have developed the present invention. It was completed.
即ち、本発明のラメラ型液晶乳化組成物の製造方法は、
（１）下記一般式（Ａ）、
（２）（Ｃ）親油性界面活性剤をラメラ型液晶乳化組成物全体に対して２～８質量％を配合して得られた配合物６～１８質量％に、
（３）（Ｄ）油性成分をラメラ型液晶乳化組成物全体に対して５～４０質量％を混合して得られた配合物に対して、
（４）（Ｅ）水溶性多価アルコールをラメラ型液晶乳化組成物全体に対して１５～４０質量％、（Ｆ）塩基性物質をラメラ型液晶乳化組成物全体に対して０．３～５質量％および（Ｇ）水をラメラ型液晶乳化組成物全体に対して８～４０質量％を混合して得られた配合物を加え、
（５）加熱して均一に混合した後に、
（６）冷却する、ラメラ型液晶乳化組成物の製造方法であり、
前記（Ａ）界面活性剤が、前記式（Ａ）中のＲ
１
がステアリル基、パルミチル基、ミリスチル基、ラウリル基またはイソステアリル基であり、これらの界面活性剤よりなる群から選ばれる１種類または２種類以上であり、
前記（Ｅ）水溶性多価アルコールが、グリセリン、１，３－ブチレングリコール、プロピレングリコール、３－メチル－１，３－ブタンジオール、１，３－プロパンジオール、２－メチル－１，３－プロパンジオール、トリメチロールプロパン、ペンタエリスリトール、ヘキシレングリコール、ジグリセリン、ジエチレングリコール、ジプロピレングリコール、ポリグリセリンおよびポリプロパンジオールからなる群から選ばれる１種類または２種類以上であり、
前記（Ｆ）塩基性物質が、水酸化ナトリウム、水酸化カリウム、クエン酸ナトリウムおよびトリエタノールアミンからなる群から選ばれる１種類または２種類以上であることを特徴とするものである。
That is, the method for producing the lamellar liquid crystal emulsion composition of the present invention is as follows:
(1) The following general formula (A),
(2) (C) Adding 2 to 8 mass % of the lipophilic surfactant to the entire lamellar liquid crystal emulsion composition to 6 to 18 mass % of the resulting mixture,
(3) (D) For a formulation obtained by mixing 5 to 40% by mass of the oily component to the entire lamellar liquid crystal emulsion composition ,
(4) (E) 15 to 40% by mass of water-soluble polyhydric alcohol based on the entire lamellar liquid crystal emulsion composition ; (F) 0.3 to 5 % of the basic substance based on the entire lamellar liquid crystal emulsion composition; % by mass and (G) a mixture obtained by mixing 8 to 40% by mass of water based on the entire lamellar liquid crystal emulsion composition ,
(5) After heating and mixing uniformly,
(6) A method for producing a lamellar liquid crystal emulsion composition, which comprises cooling,
The surfactant (A) is one type selected from the group consisting of these surfactants, wherein R 1 in the formula (A) is a stearyl group, a palmityl group, a myristyl group, a lauryl group, or an isostearyl group. or two or more types,
The water-soluble polyhydric alcohol (E) is glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propane. One or more types selected from the group consisting of diol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, diethylene glycol, dipropylene glycol, polyglycerin and polypropanediol,
The basic substance (F) is one or more selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium citrate, and triethanolamine .
さらに、本発明のラメラ型液晶乳化組成物の製造方法は、前記（Ｅ）水溶性多価アルコールが、グリセリン、１，３－ブチレングリコール、プロピレングリコール、３－メチル－１，３－ブタンジオール、１，３－プロパンジオール、２－メチル－１，３－プロパンジオール、トリメチロールプロパン、ペンタエリスリトール、ヘキシレングリコール、ジグリセリン、ジエチレングリコール、ジプロピレングリコール、ポリグリセリンおよびポリプロパンジオールからなる群から選ばれる１種類または２種類以上であることが好ましい。 Furthermore, in the method for producing a lamellar liquid crystal emulsion composition of the present invention, the water-soluble polyhydric alcohol (E) is glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, selected from the group consisting of 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, diethylene glycol, dipropylene glycol, polyglycerin and polypropanediol It is preferable to use one or more types.
さらにまた、本発明のラメラ型液晶乳化組成物の製造方法は、前記（Ｆ）塩基性物質が、水酸化ナトリウム、水酸化カリウム、クエン酸ナトリウムおよびトリエタノールアミンからなる群から選ばれる１種類または２種類以上であることが好ましい。
Furthermore, in the method for producing a lamellar liquid crystal emulsion composition of the present invention, the basic substance (F) is one selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium citrate , and triethanolamine; It is preferable that there are two or more types.
本発明によると、高圧乳化装置や酸化エチレン・酸化プロピレンを付加重合した乳化剤用いずに安定性が向上したラメラ型液晶構造の乳化組成物を製造する製造方法を提供することができる。 According to the present invention, it is possible to provide a production method for producing an emulsion composition having a lamellar liquid crystal structure with improved stability without using a high-pressure emulsification device or an emulsifier obtained by addition polymerization of ethylene oxide and propylene oxide.
以下、本発明のラメラ型液晶乳化組成物の製造方法について具体的に説明する。
本発明のラメラ型液晶乳化組成物の製造方法は、本発明のラメラ型液晶乳化組成物の製造方法は、
（１）下記一般式（Ａ）、
（２）（Ｃ）親油性界面活性剤２～８質量％を配合して得られた配合物６～１８質量％に、
（３）（Ｄ）油性成分５～４０質量％を混合して得られた配合物に対して、
（４）（Ｅ）水溶性多価アルコール１５～４０質量％、（Ｆ）塩基性物質０．３～５質量％および（Ｇ）水８～４０質量％を混合して得られた配合物を加え、
（５）加熱して均一に混合した後に、
（６）冷却することを特徴とするものである。また、（１）ＨＬＢが８以上の（Ｂ）非イオン界面活性剤が、ミリスチン酸ポリグリセリル－６、ラウリン酸ポリグリセリル－１０およびステアリン酸ポリグリセリル－１０よりなる群から選ばれる１種類または２種類以上をラメラ型液晶乳化組成物全体に対して４～１０質量％を配合して得られた配合物に、
（２）（Ｃ）親油性界面活性剤をラメラ型液晶乳化組成物全体に対して２～８質量％を配合して得られた配合物６～１８質量％に、
（３）（Ｄ）油性成分をラメラ型液晶乳化組成物全体に対して５～４０質量％を混合して得られた配合物に対して、
（４）（Ｅ）水溶性多価アルコールをラメラ型液晶乳化組成物全体に対して１５～４０質量％、（Ｆ）塩基性物質をラメラ型液晶乳化組成物全体に対して０．３～５質量％および（Ｇ）水をラメラ型液晶乳化組成物全体に対して８～４０質量％を混合して得られた配合物を加え、
（５）加熱して均一に混合した後に、
（６）冷却する、ラメラ型液晶乳化組成物の製造方法である。これにより、高圧乳化装置や酸化エチレン・酸化プロピレンを付加重合した乳化剤用いずに安定性が向上したラメラ型液晶構造の乳化組成物を製造することができる。マルタ十字等の液晶はその一部が液晶構造であり、皮膚に塗布した場合、壊れてしまい皮膚への浸透性等が悪いものであった。これに対して、本発明で製造されたラメラ型液晶乳化組成物は、全体がラメラ型液晶構造をとるため、細胞間脂質に似た性質を有し、皮膚に塗布した場合、皮膚上で伸びて皮膚との親和性がよいものである。
Hereinafter, the method for producing the lamellar liquid crystal emulsion composition of the present invention will be specifically explained.
The method for producing a lamellar liquid crystal emulsion composition of the present invention includes:
(1) The following general formula (A),
(2) (C) 6 to 18 mass % of the mixture obtained by blending 2 to 8 mass % of the lipophilic surfactant,
(3) (D) For the formulation obtained by mixing 5 to 40% by mass of the oily component,
(4) A mixture obtained by mixing (E) 15 to 40% by mass of a water-soluble polyhydric alcohol, (F) 0.3 to 5% by mass of a basic substance, and (G) 8 to 40% by mass of water. In addition,
(5) After heating and mixing uniformly,
(6) It is characterized by cooling. In addition, (1) the nonionic surfactant (B) having an HLB of 8 or more is one or more selected from the group consisting of polyglyceryl-6 myristate, polyglyceryl-10 laurate, and polyglyceryl-10 stearate. To the mixture obtained by blending 4 to 10% by mass with respect to the entire lamellar liquid crystal emulsion composition,
(2) (C) Adding 2 to 8 mass % of the lipophilic surfactant to the entire lamellar liquid crystal emulsion composition to 6 to 18 mass % of the resulting mixture,
(3) (D) For a formulation obtained by mixing 5 to 40% by mass of the oily component to the entire lamellar liquid crystal emulsion composition,
(4) (E) 15 to 40% by mass of water-soluble polyhydric alcohol based on the entire lamellar liquid crystal emulsion composition; (F) 0.3 to 5% of the basic substance based on the entire lamellar liquid crystal emulsion composition; % by mass and (G) a mixture obtained by mixing 8 to 40% by mass of water based on the entire lamellar liquid crystal emulsion composition,
(5) After heating and mixing uniformly,
(6) A method for producing a lamellar liquid crystal emulsion composition, which involves cooling. As a result, it is possible to produce an emulsified composition having a lamellar liquid crystal structure with improved stability without using a high-pressure emulsifying device or an emulsifier prepared by addition polymerization of ethylene oxide and propylene oxide. Liquid crystals such as the Maltese cross partially have a liquid crystal structure, and when applied to the skin, they break and have poor permeability into the skin. In contrast, the lamellar liquid crystal emulsion composition produced in the present invention has a lamellar liquid crystal structure as a whole, so it has properties similar to intercellular lipids, and when applied to the skin, it spreads on the skin. It has good affinity with the skin .
本発明において、下記一般式（Ａ）、
In the present invention, the following general formula (A),
また、前記（Ａ）界面活性剤としては、前記式（Ａ）中のＲ１がステアリル基、パルミチル基、ミリスチル基、ラウリル基またはイソステアリル基であり、これらの界面活性剤よりなる群から選ばれる１種類または２種類以上であることが好ましい。具体的には、例えば、理研ビタミン株式会社製のポエムＢ－３０（商品名）、ポエムＢ－１０（商品名）、花王株式会社製のステップＳＳ（商品名）等を使用することができる。 The surfactant (A) may be a surfactant in which R 1 in the formula (A) is a stearyl group, a palmityl group, a myristyl group, a lauryl group or an isostearyl group, and a surfactant selected from the group consisting of these surfactants. It is preferable that one type or two or more types are used. Specifically, for example, Poem B-30 (trade name), Poem B-10 (trade name) manufactured by Riken Vitamin Co., Ltd., Step SS (trade name) manufactured by Kao Corporation, etc. can be used.
本発明において、ＨＬＢが８以上の（Ｂ）非イオン界面活性剤は、ミリスチン酸ポリグリセリル－６、ラウリン酸ポリグリセリル－１０およびステアリン酸ポリグリセリル－１０よりなる群から選ばれる１種類または２種類以上であり、ＨＬＢが８以上の（Ｂ）非イオン界面活性剤としては、本発明の効果が得られれば、通常、化粧料等に使用できるものを使用することができる。かかる（Ｂ）非イオン界面活性剤としては、例えば、日光ケミカルズ株式会社製のＮＩＫＫＯＬ Ｈｅｘａｇｌｙｎ １-Ｍ（商品名）、ＮＩＫＫＯＬ ＤＥＣＡＧＬＹＮ １-５０ＳＶ（商品名）等、理研ビタミン株式会社製のポエム Ｊ－００２１（商品名）、ポエム Ｊ－００８１Ｈｖ（商品名）等を挙げることができる。
In the present invention , the nonionic surfactant (B) having an HLB of 8 or more is one or more selected from the group consisting of polyglyceryl-6 myristate, polyglyceryl-10 laurate, and polyglyceryl-10 stearate. As the nonionic surfactant (B) having an HLB of 8 or more, those that can be used in cosmetics and the like can be used as long as the effects of the present invention can be obtained . Examples of the nonionic surfactant (B) include NIKKOL Hexaglyn 1-M (trade name) manufactured by Nikko Chemicals Co., Ltd., NIKKOL DECAGLYN 1-50SV (trade name) manufactured by Riken Vitamin Co., Ltd., and Poem J- manufactured by Riken Vitamin Co., Ltd. 0021 (trade name), Poem J-0081Hv (trade name), etc.
さらに、本発明において、前記（Ｃ）親油性界面活性剤としては、本発明の効果が得られれば、通常、化粧料等に使用できるものを使用することができ、例えば、モノステアリン酸グリセリル、プロピレングリコール脂肪酸エステル、グリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ソルビトール脂肪酸エステル、ポリオキシエチレンソルビトール脂肪酸エステル、ポリエチレングリコール脂肪酸エステルから選ばれるＨＬＢ５以下のものを用いることができる。中でも、モノステアリン酸グリセリルが好ましく、他の界面活性剤を含んでいてもよい。具体的には、例えば、日光ケミカルズ株式会社製のＮＩＫＫＯＬ ＭＧＳ－ＢＶ２（商品名）、ＮＩＫＫＯＬ ＭＧＳ－ＢＳＥＶ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－ＡＶ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－Ｆ２０Ｖ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－Ｆ４０Ｖ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－Ｆ５０Ｖ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－Ｆ５０ＳＥＶ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－Ｆ７５Ｖ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－ＡＳＥＶ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－１５０Ｖ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－ＣＶ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－ＤＥＸＶ（商品名）、ＮＩＫＫＯＬ ＭＧＳ－ＴＧＶ（商品名）等を挙げることができる。 Furthermore, in the present invention, as the lipophilic surfactant (C), those that can be normally used in cosmetics etc. can be used as long as the effects of the present invention can be obtained, such as glyceryl monostearate, Those with an HLB of 5 or less selected from propylene glycol fatty acid ester, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, sorbitan fatty acid ester, sorbitol fatty acid ester, polyoxyethylene sorbitol fatty acid ester, and polyethylene glycol fatty acid ester can be used. Among these, glyceryl monostearate is preferred, and may contain other surfactants. Specifically, for example, NIKKOL MGS-BV2 (product name), NIKKOL MGS-BSEV (product name), NIKKOL MGS-AV (product name), NIKKOL MGS-F20V (product name), NIKKOL manufactured by Nikko Chemicals Co., Ltd. MGS-F40V (product name), NIKKOL MGS-F50V (product name), NIKKOL MGS-F50SEV (product name), NIKKOL MGS-F75V (product name), NIKKOL MGS-ASEV (product name), NIKKOL MGS-150V (product name) Examples include NIKKOL MGS-CV (product name), NIKKOL MGS-DEXV (product name), and NIKKOL MGS-TGV (product name).
さらにまた、本発明において、前記（Ｄ）油性成分としては、本発明の効果が得られれば、通常、化粧料等に使用できるものを使用することができ、例えば、流動パラフィン（ミネラルオイル）、重質流動イソパラフィン、軽質流動イソパラフィン、α－オレフィンオリゴマー、ポリイソブテン、水添ポリイソブテン、ポリブテン、スクワラン、オリーブ由来スクワラン、スクワレン、ワセリン、固型パラフィン等の炭化水素類、キャンデリラワックス、カルナウバワックス、ライスワックス、木ろう、みつろう、モンタンワックス、オゾケライト、セレシン、パラフィンワックス、マイクロクリスタリンワックス、ペトロラタム、フィッシャートロプシュワックス、ポリエチレンワックス、エチレン・プロピレンコポリマー等のワックス類、ヤシ油、パーム油、パーム核油、サフラワー油、オリーブ油、ヒマシ油、アボカド油、ゴマ油、茶油、月見草油、小麦胚芽油、マカデミアナッツ油、ヘーゼルナッツ油、ククイナッツ油、ローズヒップ油、メドウフォーム油、パーシック油、ティートリー油、ハッカ油、トウモロコシ油、ナタネ油、ヒマワリ油、小麦胚芽油、アマニ油、綿実油、大豆油、落花生油、コメヌカ油、カカオ脂、シア脂、水素添加ヤシ油、水素添加ヒマシ油、ホホバ油、水素添加ホホバ油等の植物油脂類、牛脂、乳脂、馬脂、卵黄油、ミンク油、タートル油等の動物性油脂類、鯨ロウ、ラノリン、オレンジラッフィー油等の動物性ロウ類、液状ラノリン、還元ラノリン、吸着精製ラノリン、酢酸ラノリン、酢酸液状ラノリン、ヒドロキシラノリン、ポリオキシエチレンラノリン、ラノリン脂肪酸、硬質ラノリン脂肪酸、ラノリンアルコール、酢酸ラノリンアルコール、酢酸（セチル・ラノリル）エステル等のラノリン類、レシチン、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、ホスファチジルグリセロール、ホスファチジルイノシトール、スフィンゴミエリン等のスフィンゴリン脂質、ホスファチジン酸、リゾレシチン等のリン脂質類、水素添加大豆リン脂質、部分水素添加大豆リン脂質、水素添加卵黄リン脂質、部分水素添加卵黄リン脂質等のリン脂質誘導体類、コレステロール、ジヒドロコレステロール、ラノステロール、ジヒドロラノステロール、フィトステロール、コール酸等のステロール類、サポゲニン類、サポニン類、酢酸コレステリル、ノナン酸コレステリル、ステアリン酸コレステリル、イソステアリン酸コレステリル、オレイン酸コレステリル、Ｎ－ラウロイル－Ｌ－グルタミン酸ジ（コレステリル／ベヘニル／オクチルドデシル）、Ｎ－ラウロイル－Ｌ－グルタミン酸ジ（コレステリル／オクチルドデシル）、Ｎ－ラウロイル－Ｌ－グルタミン酸ジ（フィトステリル／ベヘニル／オクチルドデシル）、Ｎ－ラウロイル－Ｌ－グルタミン酸ジ（フィトステリル／オクチルドデシル）、Ｎ－ラウロイルサルコシンイソプロピル等のアシルサルコシンアルキルエステル、１２－ヒドロキシステアリン酸コレステリル、マカデミアナッツ油脂肪酸コレステリル、マカデミアナッツ油脂肪酸フィトステリル、イソステアリン酸フィトステリル、軟質ラノリン脂肪酸コレステリル、硬質ラノリン脂肪酸コレステリル、長鎖分岐脂肪酸コレステリル、長鎖α－ヒドロキシ脂肪酸コレステリル等のステロールエステル類、リン脂質・コレステロール複合体、リン脂質・フィトステロール複合体等の脂質複合体、ミリスチン酸オクチルドデシル、ミリスチン酸ヘキシルデシル、イソステアリン酸オクチルドデシル、パリミチン酸セチル、パルミチン酸オクチルドデシル、オクタン酸セチル、オクタン酸ヘキシルデシル、イソノナン酸イソトリデシル、イソノナン酸イソノニル、イソノナン酸オクチル、イソノナン酸イソトリデシル、ネオペンタン酸イソデシル、ネオペンタン酸イソトリデシル、ネオペンタン酸イソステアリル、ネオデカン酸オクチルドデシル、オレイン酸オレイル、オレイン酸オクチルドデシル、リシノレイン酸オクチルドデシル、ラノリン脂肪酸オクチルドデシル、ジメチルオクタン酸ヘキシルデシル、エルカ酸オクチルドデシル、イソステアリン酸硬化ヒマシ油、オレイン酸エチル、アボカド油脂肪酸エチル、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、パルミチン酸オクチル、イソステアリン酸イソプロピル、ラノリン脂肪酸イソプロピル、ラウリン酸メチルヘプチル、ミリスチン酸メチルヘプチル、パルミチン酸メチルヘプチル、イソステアリン酸メチルヘプチル、セバシン酸ジエチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、アジピン酸ジイソプロピル、セバシン酸ジブチルオクチル、アジピン酸ジイソブチル、コハク酸ジオクチル、クエン酸トリエチル等のモノアルコールカルボン酸エステル類、乳酸セチル、リンゴ酸ジイソステアリル、モノイソステアリン酸水添ヒマシ油、γ－エルカラクトン等のオキシ酸エステル類、トリオクタン酸グリセリル、トリオレイン酸グリセリル、トリイソステアリン酸グリセリル、ジイソステアリン酸グリセリル、トリ（カプリル酸／カプリン酸）グリセリル、トリ（カプリル酸／カプリン酸／ミリスチン酸／ステアリン酸）グリセリル、水添ロジントリグリセリド（水素添加エステルガム）、ロジントリグリセリド（エステルガム）、ベヘン酸エイコサン二酸グリセリル、トリオクタン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、ジオクタン酸ネオペンチルグリコール、ジカプリン酸ネオペンチルグリコール、ジオクタン酸２－ブチル－２－エチル－１，３－プロパンジオール、ジオレイン酸プロピレングリコール、テトラオクタン酸ペンタエリスリチル、水素添加ロジンペンタエリスリチル、トリエチルヘキサン酸ジトリメチロールプロパン、（イソステアリン酸／セバシン酸）ジトリメチロールプロパン、トリエチルヘキサン酸ペンタエリスリチル、（ヒドロキシステアリン酸／ステアリン酸／ロジン酸）ジペンタエリスリチル、ジイソステアリン酸ジグリセリル、テトライソステアリン酸ポリグリセリル、ノナイソステアリン酸ポリグリセリル－１０、デカ（エルカ酸／イソステアリン酸／リシノレイン酸）ポリグリセリル－８、（ヘキシルデカン酸／セバシン酸）ジグリセリルオリゴエステル、ジステアリン酸グリコール（ジステアリン酸エチレングリコール）、ジネオペンタン酸３－メチル－１，５－ペンタンジオール、ジネオペンタン酸２，４－ジエチル－１，５－ペンタンジオール等の多価アルコール脂肪酸エステル類、ダイマージリノール酸ジイソプロピル、ダイマージリノール酸ジイソステアリル、ダイマージリノール酸ジ（イソステアリル／フィトステリル）、ダイマージリノール酸（フィトステリル／ベヘニル）、ダイマージリノール酸（フィトステリル／イソステアリル／セチル／ステアリル／ベヘニル）、ダイマージリノール酸ダイマージリノレイル、ジイソステアリン酸ダイマージリノレイル、ダイマージリノレイル水添ロジン縮合物、ダイマージリノール酸硬化ヒマシ油、ヒドロキシアルキルダイマージリノレイルエーテル等のダイマー酸若しくはダイマージオールの誘導体、セタノール、ミリスチルアルコール、オレイルアルコール、ラウリルアルコール、セトステアリルアルコール、ステアリルアルコール、アラキルアルコール、ベヘニルアルコール、ホホバアルコール、キミルアルコール、セラキルアルコール、バチルアルコール、ヘキシルデカノール、イソステアリルアルコール、２－オクチルドデカノール、ダイマージオール等の高級アルコール類、ベンジルアルコール等のアラルキルアルコール及び誘導体、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、イソステアリン酸、ベヘン酸、ウンデシレン酸、１２－ヒドロキシステアリン酸、パルミトオレイン酸、オレイン酸、リノール酸、リノレイン酸、エルカ酸、ドコサヘキサエン酸、エイコサペンタエン酸、イソヘキサデカン酸、アンテイソヘンイコサン酸、長鎖分岐脂肪酸、ダイマー酸、水素添加ダイマー酸等の高級脂肪酸類及びそのアルミニウム塩、カルシウム塩、マグネシウム塩、亜鉛塩、カリウム、ナトリウム塩等の金属石けん類、及びアミド等の含窒素誘導体類、ヤシ油脂肪酸モノエタノールアミド（コカミドＭＥＡ）、ヤシ油脂肪酸ジエタノールアミド（コカミドＤＥＡ）、ラウリン酸モノエタノールアミド（ラウラミドＭＥＡ）、ラウリン酸ジエタノールアミド（ラウラミドＤＥＡ）、ラウリン酸モノイソプロパノールアミド（ラウラミドＭＩＰＡ）、パルミチン酸モノエタノールアミド（パルタミドＭＥＡ）、パルミチン酸ジエタノールアミド（パルタミドＤＥＡ）、ヤシ油脂肪酸メチルエタノールアミド（コカミドメチルＭＥＡ）等の脂肪酸アルカノールアミド類、ジメチコン（ジメチルポリシロキサン）、高重合ジメチコン（高重合ジメチルポリシロキサン）、シクロメチコン（環状ジメチルシロキサン、デカメチルシクロペンタシロキサン）、フェニルトリメチコン、ジフェニルジメチコン、フェニルジメチコン、（アミノエチルアミノプロピルメチコン／ジメチコン）コポリマー、ジメチコノール、ジメチコノールクロスポリマー、シリコーン樹脂、シリコーンゴム、アミノプロピルジメチコン及びアモジメチコン等のアミノ変性シリコーン、カチオン変性シリコーン、ジメチコンコポリオール等のポリエーテル変性シリコーン、ポリグリセリン変性シリコーン、糖変性シリコーン、カルボン酸変性シリコーン、リン酸変性シリコーン、硫酸変性シリコーン、アルキル変性シリコーン、脂肪酸変性シリコーン、アルキルエーテル変性シリコーン、アミノ酸変性シリコーン、ペプチド変性シリコーン、フッ素変性シリコーン、カチオン変性及びポリエーテル変性シリコーン、アミノ変性及びポリエーテル変性シリコーン、アルキル変性及びポリエーテル変性シリコーン、アミドアルキル変性シリコーン、アミノグリコール変性シリコーン、アミノフェニル変性シリコーン、ポリシロキサン・オキシアルキレン共重合体等のシリコーン類、パーフルオロデカン、パーフルオロオクタン、パーフルオロポリエーテル等のフッ素系油剤類等を挙げることができ、特に、炭化水素類、ワックス類、植物油脂類、動物性ロウ類、ラノリン類、ジメチコン（ジメチルポリシロキサン）、高重合ジメチコン（高重合ジメチルポリシロキサン）、シクロメチコン（環状ジメチルシロキサン、デカメチルシクロペンタシロキサン）、フェニルトリメチコン、ジフェニルジメチコン、フェニルジメチコン、（アミノエチルアミノプロピルメチコン／ジメチコン）コポリマー、ジメチコノール、ジメチコノールクロスポリマー、シリコーン樹脂、シリコーンゴムであることが好ましい。 Furthermore, in the present invention, as the oily component (D), as long as the effects of the present invention can be obtained, those that can be normally used in cosmetics etc. can be used, such as liquid paraffin (mineral oil), Heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, vaseline, hydrocarbons such as solid paraffin, candelilla wax, carnauba wax, rice Waxes such as wax, Japanese wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer, coconut oil, palm oil, palm kernel oil, sugar Flower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn Oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, etc. vegetable oils and fats, animal fats and oils such as beef tallow, milk fat, horse tallow, egg yolk oil, mink oil, and turtle oil, animal waxes such as spermaceti, lanolin, and orange roughy oil, liquid lanolin, reduced lanolin, and adsorption. Purified lanolin, acetic acid lanolin, acetic acid liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, acetic acid lanolin alcohol, acetic acid (cetyl lanolyl) ester, lecithin, phosphatidylcholine, phosphatidyl ethanol Amine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phosphatidic acid, phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partial hydrogen Phospholipid derivatives such as added egg yolk phospholipid, cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, sterols such as cholic acid, sapogenins, saponins, cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate , cholesteryl oleate, N-lauroyl-L-glutamate di(cholesteryl/behenyl/octyldodecyl), N-lauroyl-L-glutamate di(cholesteryl/octyldodecyl), N-lauroyl-L-glutamate di(phytosteryl/behenyl/ octyldodecyl), di(phytosteryl/octyldodecyl) N-lauroyl-L-glutamate, acylsarcosine alkyl esters such as N-lauroylsarcosine isopropyl, cholesteryl 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid, phytosteryl macadamia nut oil fatty acid, isostearic acid Sterol esters such as phytosteryl, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl, lipid complexes such as phospholipid/cholesterol complexes, phospholipid/phytosterol complexes, Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octoate, hexyldecyl octoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, neopentane Isodecyl acid, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid curing Castor oil, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methyl isostearate Monoalcohol carboxylic acid esters such as heptyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate, cetyl lactate, diisomalate Stearyl, hydrogenated castor oil monoisostearate, oxyacid esters such as γ-ercalactone, glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri(caprylic/capric) glyceryl, (Caprylic acid/Capric acid/Myristic acid/Stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eicosanedioate behenate, trimethylolpropane trioctanoate, triisostearate triglyceride Methylolpropane, neopentyl glycol dioctoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl , ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearic acid/sebacic acid), pentaerythrityl triethylhexanoate, dipentaerythrityl (hydroxystearic acid/stearic acid/rosin acid), diglyceryl diisostearate, polyglyceryl tetraisostearate, nona Polyglyceryl isostearate-10, deca (erucic acid/isostearic acid/ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid/sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate), 3-methyl dineopentanoate-1 , 5-pentanediol, polyhydric alcohol fatty acid esters such as 2,4-diethyl-1,5-pentanediol dineopentanoate, diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, di(isostearyl dimer dilinoleate) stearyl/phytosteryl), dimer dilinoleic acid (phytosteryl/behenyl), dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl), dimer dilinoleyl diisostearate, dimer dilinoleyl diisostearate, dimer dilinoleyl diisostearate Linoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, derivatives of dimer acid or dimer diol such as hydroxyalkyl dimer dilinoleyl ether, cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol , higher alcohols such as aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, serakyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimer diol, aralkyl alcohols and derivatives such as benzyl alcohol, Lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid , isohexadecanoic acid, anteisoheneicosanoic acid, long-chain branched fatty acids, dimer acid, hydrogenated dimer acid, and other higher fatty acids, and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, and metal salts such as sodium salts. Soaps and nitrogen-containing derivatives such as amides, coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (Lauramide MEA), lauric acid diethanolamide (Lauramide DEA) ), fatty acid alkanolamides such as lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palutamide MEA), palmitic acid diethanolamide (palutamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA), dimethicone ( dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, (aminoethylaminopropylmethicone/dimethicone) copolymer , dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicone such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid Modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone, peptide modified silicone, fluorine modified silicone, cation modified and polyether modified silicone, amino modified and polyether Silicones such as modified silicone, alkyl-modified and polyether-modified silicone, amide alkyl-modified silicone, aminoglycol-modified silicone, aminophenyl-modified silicone, polysiloxane-oxyalkylene copolymer, perfluorodecane, perfluorooctane, perfluoropolymer Examples include fluorine-based oils such as ethers, and in particular, hydrocarbons, waxes, vegetable oils, animal waxes, lanolin, dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethyl polysiloxane), etc. siloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, (aminoethylaminopropyl methicone/dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber. It is preferable that there be.
また、本発明において、前記（Ｅ）水溶性多価アルコールとしては、本発明の効果が得られれば、通常、化粧料等に使用できるものを使用することができ、例えば、グリセリン、１，３－ブチレングリコール、プロピレングリコール、３－メチル－１，３－ブタンジオール、１，３－プロパンジオール、２－メチル－１，３－プロパンジオール、トリメチロールプロパン、ペンタエリスリトール、ヘキシレングリコール、ジグリセリン、ジエチレングリコール、ジプロピレングリコール、ポリグリセリンおよびポリプロパンジオールからなる群から選ばれる１種類または２種類以上であることが好ましく、中でも、グリセリン、ジグリセリン、ジエチレングリコールおよびジプロピレングリコールからなる群から選ばれる１種類または２種類以上であることよりが好ましい。さらに、特に、グリセリン等の３価のアルコールを使用することにより、より安定性が向上したラメラ型液晶構造の乳化組成物を製造することができる。 In addition, in the present invention, as the water-soluble polyhydric alcohol (E), those that can be normally used in cosmetics etc. can be used as long as the effects of the present invention can be obtained, such as glycerin, 1,3 -Butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, One or more types selected from the group consisting of diethylene glycol, dipropylene glycol, polyglycerin, and polypropanediol are preferable, and among them, one type selected from the group consisting of glycerin, diglycerin, diethylene glycol, and dipropylene glycol. Or it is more preferable that there are two or more types. Furthermore, especially by using a trihydric alcohol such as glycerin, it is possible to produce an emulsion composition having a lamellar liquid crystal structure with improved stability.
また、本発明において、前記（Ｆ）塩基性物質としては、本発明の効果が得られれば、通常、化粧料等に使用できるものを使用することができ、例えば、塩化ナトリウム、塩化カリウム、塩化マグネシウムおよび塩化カルシウム等の無機塩や、酢酸、プロピオン酸、グリコール酸、乳酸、リンゴ酸、酒石酸およびクエン酸等の有機酸のナトリウム塩、カリウム塩、マグネシウム塩およびカルシウム塩、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、イソプロパノールアミン、トリイソプロパノールアミン、２－アミノ－２－メチル－１，３ープロパンジオール、２－アミノ－２－ヒドロキシメチル－１，３－プロパンジオール、アンモニア水、炭酸アンモニウム等のアミン化合物を用いることができ、中でも水酸化ナトリウム、水酸化カリウム、クエン酸ナトリウムおよびトリエタノールアミンからなる群から選ばれる１種類または２種類以上であることが好ましい。一般に、（Ｆ）塩基性物質は乳化安定性を損なうために、例えば、特許第３９８７５５１号公報および特許第３９８７５５２号公報に記載の比較例のように前記（Ｆ）塩基性物質用いないことが通常であるが、本発明では、前記（Ｆ）塩基性物質を用いることでより安定性が向上したラメラ型液晶構造の乳化組成物を製造することができることを見出したものである。
In addition, in the present invention, as the basic substance (F), those that can be normally used in cosmetics etc. can be used as long as the effects of the present invention can be obtained. For example, sodium chloride, potassium chloride, chloride Inorganic salts such as magnesium and calcium chloride, sodium, potassium, magnesium and calcium salts of organic acids such as acetic acid, propionic acid, glycolic acid, lactic acid, malic acid, tartaric acid and citric acid, monoethanolamine, diethanolamine, Amines such as triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol , ammonia water, ammonium carbonate, etc. Among them, one or more compounds selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium citrate , and triethanolamine are preferred. In general, since the basic substance (F) impairs emulsion stability, it is usually not necessary to use the basic substance (F), for example, as in the comparative examples described in Japanese Patent No. 3987551 and Japanese Patent No. 3987552. However, in the present invention, it has been discovered that by using the basic substance (F), it is possible to produce an emulsion composition having a lamellar liquid crystal structure with improved stability.
さらに、本発明において、前記（Ｇ）水としては、本発明の効果が得られれば、通常、化粧料等に使用できるものを使用することができ、精製水等を使用することができる。 Further, in the present invention, as the water (G), any water that can be normally used in cosmetics etc. can be used, as long as the effects of the present invention can be obtained, and purified water etc. can be used.
さらに、本発明において、ラメラ型液晶乳化組成物の製造方法は、（１）前記一般式（Ａ）で表わされる（Ａ）界面活性剤と前記一般式（Ｂ）で表わされるＨＬＢが８以上の（Ｂ）非イオン界面活性剤とからなる群から選ばれる１種類または２種類以上を４～１０質量％を配合して得られた配合物に、（２）（Ｃ）親油性界面活性剤２～８質量％を配合して得られた配合物６～１８質量％に、（３）（Ｄ）油性成分５～４０質量％を混合して得られた配合物に対して、（４）（Ｅ）水溶性多価アルコール１５～４０質量％、（Ｆ）塩基性物質０．３～５質量％および（Ｇ）水８～４０質量％を混合して得られた配合物を加え、（５）加熱して均一に混合した後に、（６）冷却する、という工程を行えばよく、通常の化粧料の製造方法で製造することができ、加熱温度や撹拌条件等は、成分にあわせて調整して製造することができる。 Further, in the present invention, the method for producing a lamellar liquid crystal emulsion composition includes (1) a surfactant represented by the above general formula (A) and an HLB of 8 or more represented by the above general formula (B). (B) nonionic surfactant, and (2) (C) lipophilic surfactant 2. (4)( E) A mixture obtained by mixing 15 to 40% by mass of a water-soluble polyhydric alcohol, (F) 0.3 to 5% by mass of a basic substance, and (G) 8 to 40% by mass of water is added, and (5 ) After heating and mixing uniformly, (6) cooling can be performed, and the cosmetics can be manufactured using normal cosmetic manufacturing methods, with heating temperature, stirring conditions, etc. adjusted according to the ingredients. It can be manufactured by
また、本発明において、ラメラ型液晶乳化組成物の製造方法は、（１）前記一般式（Ａ）で表わされる（Ａ）界面活性剤と前記一般式（Ｂ）で表わされるＨＬＢが８以上の（Ｂ）非イオン界面活性剤とからなる群から選ばれる１種類または２種類以上を６～８質量％を配合して得られた配合物に、（２）（Ｃ）親油性界面活性剤４～５質量％を配合して得られた配合物１０～１３質量％に、（３）（Ｄ）油性成分２０～４０質量％を混合して得られた配合物に対して、（４）（Ｅ）水溶性多価アルコール２０～３０質量％、（Ｆ）塩基性物質０．３～５質量％および（Ｇ）水２０～４０質量％を混合して得られた配合物を加え、（５）加熱して均一に混合した後に、（６）冷却することが好ましい。これにより、より安定性が向上したラメラ型液晶構造の乳化組成物を製造することができる。 In addition, in the present invention, the method for producing a lamellar liquid crystal emulsion composition includes (1) a surfactant represented by the above general formula (A) and an HLB of 8 or more represented by the above general formula (B). (B) nonionic surfactant, and (2) (C) lipophilic surfactant 4 to a mixture obtained by blending 6 to 8% by mass of one or more selected from the group consisting of nonionic surfactant. (4)( E) A mixture obtained by mixing 20 to 30% by mass of a water-soluble polyhydric alcohol, (F) 0.3 to 5% by mass of a basic substance, and (G) 20 to 40% by mass of water is added, and (5 ) After heating and mixing uniformly, it is preferable to (6) cool the mixture. Thereby, an emulsion composition having a lamellar liquid crystal structure with improved stability can be produced.
また、本発明の用途としては化粧料に用いることができ、かかる化粧料は、人間の身体等に使用できるものであり、化粧品を主とするものであるが、医薬部外品、医薬品等の用途を排除するものではない。さらに、前記化粧品とは、基礎化粧品、メイクアップ化粧品、頭髪用化粧品、入浴剤等を含むものである。 In addition, the present invention can be used in cosmetics, which can be used on the human body, etc., and are mainly used for cosmetics, but can also be used for quasi-drugs, pharmaceuticals, etc. This does not exclude other uses. Further, the cosmetics include basic cosmetics, makeup cosmetics, hair cosmetics, bath additives, and the like.
さらに、本発明において、本発明の効果が損なわれない範囲で、適宜他の成分等を添加することもできる。質的、量的範囲で上記以外の任意の成分を配合することができ、化粧料等に通常配合される成分、例えば、保湿剤、酸化防止剤、防腐剤、香料、各種ビタミン剤、キレート剤、着色剤、紫外線吸収剤、薬効成分等を配合することができる。 Furthermore, in the present invention, other components may be added as appropriate to the extent that the effects of the present invention are not impaired. Any ingredient other than the above can be added qualitatively and quantitatively, and ingredients that are usually added to cosmetics, such as moisturizers, antioxidants, preservatives, fragrances, various vitamins, and chelating agents. , colorants, ultraviolet absorbers, medicinal ingredients, etc. can be added.
さらにまた、本発明において、液晶形成の確認は、液晶は光学異方性を有するので偏光顕微鏡により確認することができる。また、液晶以外の乳化粒子の生成は位相差顕微鏡により確認できる。偏光顕微鏡としては、例えば、オリンパス株式会社製のＣＸ４１（商品名）を使用することができ、位相差顕微鏡としては、例えば、オリンパス株式会社製のＣＫＸ５３－２２ＰＨＫ（商品名）を使用することができる。 Furthermore, in the present invention, the formation of liquid crystals can be confirmed using a polarizing microscope since liquid crystals have optical anisotropy. Furthermore, the formation of emulsified particles other than liquid crystal can be confirmed using a phase contrast microscope. As a polarizing microscope, for example, CX41 (trade name) manufactured by Olympus Corporation can be used, and as a phase contrast microscope, for example, CKX53-22PHK (trade name) manufactured by Olympus Corporation can be used. .
以下、本発明について、実施例を用いてさらに詳細に説明するが、本発明はこれらの実施例に限定されるものではない。また、以下、処方中の数値は質量％を示す。 EXAMPLES Hereinafter, the present invention will be explained in more detail using Examples, but the present invention is not limited to these Examples. Further, hereinafter, numerical values in the prescription indicate mass %.
（実施例１および比較例１）
下記表１記載の処方に従って、実施例１のラメラ型液晶乳化組成物および比較例１の乳化組成物を作製した。得られたラメラ型液晶乳化組成物および乳化組成物を、株式会社ハイロックス社製の顕微鏡ＲＨ-２０００（商品名）、３５０倍の際に用いたレンズ（ＭＸＢ-２５００ＲＥＺ（商品名））、７００倍の際に用いたレンズ（ＭＸＢ－１０Ｃ：ＯＬ－７００ＩＩ（商品名））および偏光アダプタ（ＡＤＢ－２５ｐ１（商品名））を使用して液晶の有無および２倍希釈したときの液晶の有無を観察した。
(Example 1 and Comparative Example 1)
A lamellar liquid crystal emulsion composition of Example 1 and an emulsion composition of Comparative Example 1 were prepared according to the formulations shown in Table 1 below. The obtained lamellar liquid crystal emulsion composition and emulsion composition were subjected to a microscope RH-2000 (trade name) manufactured by Hirox Co., Ltd., a lens used for 350x magnification (MXB-2500REZ (trade name)), 700x magnification. Using the lens (MXB-10C: OL-700II (product name)) and polarization adapter (ADB-25p1 (product name)) used for magnification, check the presence or absence of liquid crystal and the presence or absence of liquid crystal when diluted by 2 times. Observed.
図１は、実施例１のラメラ型液晶乳化組成物の顕微鏡写真であり、図２は、実施例１のラメラ型液晶乳化組成物の偏光顕微鏡写真であり、図３は、実施例１のラメラ型液晶乳化組成物を２倍希釈したときの顕微鏡写真であり、図４は、実施例１のラメラ型液晶乳化組成物を２倍希釈したときの偏光顕微鏡写真である。図１～図４に示すように、実施例１のラメラ型液晶乳化組成物は、２倍希釈してもラメラ型液晶構造を維持でき、安定性が向上したラメラ型液晶乳化組成物であった。一方、比較例１の乳化組成物は、一部に液晶構造は確認できたが、２倍希釈することで完全に液晶構造が崩れ、液晶構造を維持できない乳化組成物であった。
1 is a photomicrograph of the lamellar liquid crystal emulsion composition of Example 1, FIG. 2 is a polarized light micrograph of the lamellar liquid crystal emulsion composition of Example 1, and FIG. 3 is a photomicrograph of the lamellar liquid crystal emulsion composition of Example 1. FIG. 4 is a polarized light micrograph of the lamellar liquid crystal emulsion composition of Example 1 diluted two times. As shown in FIGS. 1 to 4, the lamellar liquid crystal emulsion composition of Example 1 was able to maintain the lamellar liquid crystal structure even when diluted 2 times, and was a lamellar liquid crystal emulsion composition with improved stability. . On the other hand, in the emulsion composition of Comparative Example 1, although a liquid crystal structure could be confirmed in part, the liquid crystal structure was completely destroyed by doubling dilution, and the emulsion composition was unable to maintain the liquid crystal structure.
Claims (1)
（２）（Ｃ）親油性界面活性剤をラメラ型液晶乳化組成物全体に対して２～８質量％を配合して得られた配合物６～１８質量％に、
（３）（Ｄ）油性成分をラメラ型液晶乳化組成物全体に対して５～４０質量％を混合して得られた配合物に対して、
（４）（Ｅ）水溶性多価アルコールをラメラ型液晶乳化組成物全体に対して１５～４０質量％、（Ｆ）塩基性物質をラメラ型液晶乳化組成物全体に対して０．３～５質量％および（Ｇ）水をラメラ型液晶乳化組成物全体に対して８～４０質量％を混合して得られた配合物を加え、
（５）加熱して均一に混合した後に、
（６）冷却する、ラメラ型液晶乳化組成物の製造方法であり、
前記（Ａ）界面活性剤が、前記式（Ａ）中のＲ １ がステアリル基、パルミチル基、ミリスチル基、ラウリル基またはイソステアリル基であり、これらの界面活性剤よりなる群から選ばれる１種類または２種類以上であり、
前記（Ｅ）水溶性多価アルコールが、グリセリン、１，３－ブチレングリコール、プロピレングリコール、３－メチル－１，３－ブタンジオール、１，３－プロパンジオール、２－メチル－１，３－プロパンジオール、トリメチロールプロパン、ペンタエリスリトール、ヘキシレングリコール、ジグリセリン、ジエチレングリコール、ジプロピレングリコール、ポリグリセリンおよびポリプロパンジオールからなる群から選ばれる１種類または２種類以上であり、
前記（Ｆ）塩基性物質が、水酸化ナトリウム、水酸化カリウム、クエン酸ナトリウムおよびトリエタノールアミンからなる群から選ばれる１種類または２種類以上であることを特徴とするラメラ型液晶乳化組成物の製造方法。 (1) The following general formula (A),
(2) (C) Adding 2 to 8 mass % of the lipophilic surfactant to the entire lamellar liquid crystal emulsion composition to 6 to 18 mass % of the resulting mixture,
(3) (D) For a formulation obtained by mixing 5 to 40% by mass of the oily component to the entire lamellar liquid crystal emulsion composition ,
(4) (E) 15 to 40% by mass of water-soluble polyhydric alcohol based on the entire lamellar liquid crystal emulsion composition ; (F) 0.3 to 5 % of the basic substance based on the entire lamellar liquid crystal emulsion composition; % by mass and (G) a mixture obtained by mixing 8 to 40% by mass of water based on the entire lamellar liquid crystal emulsion composition ,
(5) After heating and mixing uniformly,
(6) A method for producing a lamellar liquid crystal emulsion composition, which comprises cooling,
The surfactant (A) is one type selected from the group consisting of these surfactants, wherein R 1 in the formula (A) is a stearyl group, a palmityl group, a myristyl group, a lauryl group, or an isostearyl group. or two or more types,
The water-soluble polyhydric alcohol (E) is glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propane. One or more types selected from the group consisting of diol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, diethylene glycol, dipropylene glycol, polyglycerin and polypropanediol,
A lamellar liquid crystal emulsion composition, wherein the basic substance (F) is one or more selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium citrate, and triethanolamine. manufacturing method.
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| JP2019072211A (en) * | 2017-10-16 | 2019-05-16 | 株式会社三洋物産 | Game machine |
| JP2019072207A (en) * | 2017-10-16 | 2019-05-16 | 株式会社三洋物産 | Game machine |
| JP2019072210A (en) * | 2017-10-16 | 2019-05-16 | 株式会社三洋物産 | Game machine |
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| JP2019072204A (en) * | 2017-10-16 | 2019-05-16 | 株式会社三洋物産 | Game machine |
| JP2019072206A (en) * | 2017-10-16 | 2019-05-16 | 株式会社三洋物産 | Game machine |
| JP2019072203A (en) * | 2017-10-16 | 2019-05-16 | 株式会社三洋物産 | Game machine |
| JP2019072212A (en) * | 2017-10-16 | 2019-05-16 | 株式会社三洋物産 | Game machine |
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| KR102559008B1 (en) * | 2023-05-17 | 2023-07-25 | 주식회사 뉴앤뉴 | Liquid crystal cosmetic composition that forms a microcurrent and has excellent electrical conductivity |
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