JP7326817B2 - Adhesive backing film, laminate and adhesive - Google Patents

Description

TECHNICAL FIELD The present invention relates to a patch support film, a laminate, and a patch.

In general, plastic films have properties such as being lightweight, chemically stable, easy to process, flexible and strong, and mass-producible. Therefore, plastic films are used for various purposes. Applications of plastic films include, for example, packaging materials for packaging foodstuffs and pharmaceuticals, IV packs, shopping bags, posters, tapes, optical films used for liquid crystal televisions, protective films, window films to be laminated on windows, A wide variety of products such as vinyl houses and building materials. Appropriate plastic materials are selected for such applications depending on the application. Furthermore, a laminate is also made by stacking a plurality of types of plastic films. There is also a method of using a plurality of plastic materials mixed in one layer to compensate for the shortcomings of a single material. In many cases, appropriate film materials are selected from the viewpoint of heat resistance, mechanical strength, transparency, and the like.

In general, the mechanical properties and barrier properties of a plastic film are determined by the material and layer structure of the plastic film. For example, strength-oriented materials tend to have low extensibility. Therefore, there is a strong demand for a film material that can ensure sufficient elongation while having high strength. In addition, when barrier properties are required, it is necessary to limit the use of materials with good barrier properties, or to laminate a barrier layer in a separate process. may come.

By the way, a patch, which is typified by a patch to be stuck on the skin, contains a drug in an adhesive forming a surface to be stuck on the skin, and the drug is absorbed into the body through the skin. The support constituting the outer surface of the patch is usually composed of a laminate of film or non-woven fabric. Functions required for the backing of this patch include barrier properties against drugs (drug barrier properties) and elongation. Here, the term "drug barrier property" refers to the ability of the backing to prevent or hardly absorb the drug so that the drug can be efficiently absorbed through the skin. In addition, elongation is an important factor in suppressing the feeling of stiffness after sticking the patch to the skin and making it difficult for the pasted patch to come off during operation.

However, the current situation is that it is difficult to achieve both drug barrier properties and stretchability. In particular, materials for plastic films with chemical barrier properties are limited to some materials such as biaxially oriented PET (Polyethylene Terephthalate, polyethylene terephthalate), ethylene-vinyl alcohol copolymers, and cycloolefin copolymers. put away. These materials also have the drawback of low elongation due to their high strength.

For example, in Patent Document 1, a plastic film using a material such as PET or an ethylene-vinyl alcohol copolymer is used as a backing for an adhesive patch. There are drawbacks such as a stiff feeling and easy peeling during vigorous movement. Thus, conventionally, adhesive backing films have been required to have both drug barrier properties and elongation properties.
Further, as described in Patent Document 2, attempts have been made to achieve both drug barrier properties and elongation properties by bonding a barrier film and a soft film and forming the barrier film surface into a bellows structure. , there is a drawback that the manufacturing method is complicated.

Japanese Patent No. 6176846 JP-A-8-127531

The present invention has been made in view of the above points, and uses a patch support film as a support that has good drug barrier properties and elongation while suppressing labor and cost in manufacturing. An object of the present invention is to provide a laminate and an adhesive patch.

In order to solve the problem, the first aspect of the present invention is an adhesive patch backing film made of a resin having drug barrier properties, wherein the entire layer of the adhesive backing film has an undulating shape in the film thickness direction. By being configured as such, it has an uneven structure in which concave portions and convex portions are repeated along the surface, and in the uneven structure, the difference in height between the concave portions and the convex portions is greater than the thickness of the adhesive backing film. Largely, the bottom of the recess and the top of the projection are flat portions with a flat cross section, the film thickness of the flat portion is in the range of 5 μm or more and 150 μm or less, and a part of the flat portion is flat. The thickness of the first flat portion which is the portion is thinner than the thickness of the second flat portion which is the flat portion other than the first flat portion, and the total thickness of the adhesive backing film is 10 μm or more and 450 μm The gist is that the range is as follows.

According to an aspect of the present invention, an adhesive backing film that has a simple structure while suppressing labor and cost in manufacturing, and that has good drug barrier properties and elongation while ensuring strength as a backing, and It becomes possible to provide laminates and patches using this.

FIG. 2 is a schematic cross-sectional view showing an example of the adhesive backing film of the present embodiment. FIG. 4 is a cross-sectional schematic diagram showing an example of a modified cross-sectional shape of the adhesive backing film of the present embodiment. FIG. 4 is a cross-sectional schematic diagram showing an example of a modified cross-sectional shape of the adhesive backing film of the present embodiment. FIG. 4 is a cross-sectional schematic diagram showing an example of a modified cross-sectional shape of the adhesive backing film of the present embodiment. FIG. 4 is a cross-sectional schematic diagram showing an example of a modified cross-sectional shape of the adhesive backing film of the present embodiment. FIG. 3 is a schematic cross-sectional view for explaining the total thickness, the height difference of the uneven structure, the film thickness of the flat portions of the recesses and the protrusions, and the spacing of the uneven structure in the patch support film of the embodiment. FIG. 3 is a schematic bird's-eye view showing an example of the extending direction of the uneven structure in one section of the patch support film of the present embodiment. FIG. 4 is a schematic bird's-eye view showing another example of the extension direction of the concave-convex structure in one section of the patch support film of the present embodiment. FIG. 4 is a schematic bird's-eye view showing another example of the extension direction of the concave-convex structure in one section of the patch support film of the present embodiment. FIG. 4 is a schematic bird's-eye view showing another example of the extension direction of the concave-convex structure in one section of the patch support film of the present embodiment. FIG. 4 is a schematic bird's-eye view showing another example of the extension direction of the concave-convex structure in one section of the patch support film of the present embodiment. FIG. 4 is a schematic bird's-eye view showing an example of extending directions of the uneven structure when a plurality of sections are combined in the patch support film of the present embodiment. FIG. 4 is a schematic bird's-eye view showing another example of the extension direction of the uneven structure when a plurality of sections are combined in the patch support film of the present embodiment. It is a cross-sectional schematic diagram which shows the example of the laminated body of this embodiment. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic cross-sectional view showing an example of a patch using the patch support film of the present embodiment; It is a cross-sectional schematic diagram which shows an example of the patch using the laminated body of this embodiment. FIG. 2 is a schematic cross-sectional view showing an example of a patch using a conventional patch support film. 1 is a graph showing examples of elongation behavior of a support film according to an embodiment of the present invention and a conventional support film. FIG. 4 is a cross-sectional view showing a patch support film with a different cross-sectional shape. 2 is a graph showing the relationship between the total elongation of the film and the maximum value of local strain when the surface shape of the adhesive backing film is changed. FIG. 4 is a cross-sectional view showing a patch support film with a different cross-sectional shape.

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below with reference to the drawings.
Each figure is a schematic diagram, and the size, shape, etc. of each part are appropriately exaggerated for easy understanding. In order to simplify the explanation, the same reference numerals are given to the corresponding parts in each figure.

(Structure of adhesive backing film 1)
As shown in FIG. 1, the adhesive backing film 1 of the present embodiment is configured such that the entire layer is undulating in the film thickness direction (serpentine shape when viewed from the side). It has a concave-convex structure 4 in which concave portions 2A and convex portions 2B are repeated. The concave-convex structure 4 is formed so that the height difference between the concave portions 2A and the convex portions 2B is greater than the film thickness of the adhesive backing film 1 . The uneven structure 4 can be provided, for example, by processing the entire layer into a meandering shape along the surface direction.
The patch support film 1 can have an adhesive layer 6 containing a drug on one side 2 (top side in FIG. 1) or the other side 3 (bottom side in FIG. 1). FIG. 1 illustrates the case where the pressure-sensitive adhesive layer 6 is arranged on the surface 2 side. The patch support film 1 is made of a material having drug barrier properties against the drug contained in the adhesive layer 6 . The material of the patch support film 1 may be appropriately selected from known plastic materials having drug-barrier properties against drugs that are assumed to be used for the patch.

Materials for the patch support film 1 include, for example, polyethylene terephthalate, cycloolefin copolymers, cycloolefin polymers, polyacrylonitrile, ethylene-vinyl alcohol copolymers, and modified polymers thereof. When the patch is applied to the body, the medicinal ingredients contained in the adhesive layer 6 permeate the skin and act on the whole body through the blood. It is important that the adhesive backing film 1 used in such an adhesive patch serves as a barrier to the medicinal ingredients and does not adsorb or hardly adsorb them. The above material has good barrier properties (non-adsorption properties) to the medicinal ingredients, and functions as a support without reducing the medicinal ingredients of the patch. When the patch support film 1 is formed of such a material, it has drug barrier properties against drugs such as tulobuterol and rivastigmine.
Further, as shown in FIG. 14, on the side where the drug-containing pressure-sensitive adhesive layer 6 is not provided, it is possible to provide a functional layer 30 with or without drug-barrier properties along the concave-convex structure 4 . be. When a functional layer is provided on the side on which the drug-containing pressure-sensitive adhesive layer 6 is provided, the material of the functional layer 30 is also required to have drug barrier properties.

(Regarding uneven structure 4)
The concave-convex structure 4 has a structure in which concave portions 2A and convex portions 2B are repeated in a predetermined direction along the surface of the film. As shown in FIGS. 1 to 4, in the concave-convex structure 4 of the present embodiment, the bottoms of the concave portions 2A and the top portions of the convex portions 2B are flat portions having a flat cross-sectional shape. 1 to 4 illustrate the case where the flat portion formed by the bottom portion and the flat portion formed by the top portion are parallel to each other. Having flat surfaces parallel to each other on the bottoms of the concave portions 2A and the top portions of the convex portions 2B of the concave-convex structure is advantageous in terms of holding the drug-containing pressure-sensitive adhesive layer 6 and improving surface printability when used as an adhesive patch. becomes.
It is preferable that the plurality of flat portions forming the bottom portion are arranged on one and the same imaginary plane or the same imaginary curved surface. Similarly, the plurality of flat portions forming the apex are preferably arranged on one and the same imaginary plane or the same imaginary curved surface. The virtual curved surface consists of a smooth surface that does not have a steep curvature portion along which the radius of curvature becomes steep.
In addition, "flatness" refers to having a degree of flatness that is suitable for printing. The flatness of the patch support film is preferably, for example, an arithmetic mean roughness (Ra) of 0.3 μm or less when observed with a laser microscope at a magnification of 200.

Here, the flat part of the bottom is also described as a bottom flat part 2Aa. The top flat portion is also referred to as a top flat portion 2Ba. Moreover, the part which connects adjacent bottom flat part 2Aa and top flat part 2Ba is also described as pillar part 2C.
In the present embodiment, some of the plurality of flat portions including the bottom flat portion 2Aa and the top flat portion 2Ba are relatively thinner than the other flat portions. Hereinafter, the flat portion having a relatively thin film thickness is referred to as a first flat portion, and the other flat portion is referred to as a second flat portion.
That is, the film thickness of the first flat portion < the film thickness of the second flat portion.
The film thicknesses of the plurality of first flat portions are not necessarily equal to each other, but are preferably equal to each other. Similarly, the film thicknesses of the plurality of second flat portions are not necessarily equal to each other, but are preferably equal to each other.

The first flat portion is composed of, for example, either the bottom flat portion 2Aa or the top flat portion 2Ba.
FIG. 1 illustrates a case where the top flat portion 2Ba constitutes the first flat portion and the bottom flat portion 2Aa constitutes the second flat portion. In the case where the top flat portion 2Ba constitutes the first flat portion and the bottom flat portion 2Aa constitutes the second flat portion, not all of the top flat portions 2Ba need to be the first flat portions, but a plurality of At least 70% or more of the top flat portion 2Ba is preferably the first flat portion. Preferably 90% or more, more preferably 100% of the top flat portion 2Ba is the first flat portion.

FIG. 2 illustrates a case where the top flat portion 2Ba constitutes the second flat portion and the bottom flat portion 2Aa constitutes the first flat portion. In the case where the top flat portion 2Ba constitutes the second flat portion and the bottom flat portion 2Aa constitutes the first flat portion, it is not necessary that all of the bottom flat portions 2Aa constitute the first flat portion. At least 70% or more of the bottom flat portion 2Aa is preferably the first flat portion. Preferably 90% or more, more preferably 100% of the bottom flat portion 2Aa is the first flat portion.

Moreover, it is preferable that the number of the first flat portions is relatively larger on the central side than on the edge side of the film. When the first flat portion is relatively present on the central side of the film, when the film is pulled, the central side is relatively easier to stretch than the end portions.
Also, the first flat portion need not consist of either the bottom flat portion 2Aa or the top flat portion 2Ba. A configuration in which the first flat portion coexists in both the bottom flat portion 2Aa and the top flat portion 2Ba may be used.

FIG. 3 shows an example of a configuration in which the first flat portion is mixed with both the bottom flat portion 2Aa and the top flat portion 2Ba.
When the first flat portion exists in both the bottom flat portion 2Aa and the top flat portion 2Ba, the flat portion adjacent to the first flat portion is preferably the second flat portion. For example, the top flat portion 2Ba adjacent to the bottom flat portion 2Aa formed of the first flat portion is preferably formed of the second flat portion. The two adjacent flat portions consist of a bottom flat portion 2Aa and a top flat portion 2Ba.
At this time, the first flat portion is preferably 30% or more, preferably 40% or more of the flat portion composed of the bottom flat portion 2Aa and the top flat portion 2Ba.

In the concave-convex structure, the concave-convex positions are aligned on one surface 2 (upper surface side in FIG. 1) and the other surface 3 (lower surface side in FIG. 1) of the adhesive backing film 1, although not shown. Corners in the cross-sectional shape (positions of ridgelines 2D where flat portions and pillars 2C join) may be rounded.
Here, regarding the concave-convex structure 4, the interval D1 between the adjacent convex portions 2B and the interval D2 between the adjacent concave portions 2A (see FIG. 6) may be arranged with periodicity such as equal intervals. can be different. The intervals D1 and D2 can be appropriately set according to the desired stretched state required for the patch. Further, as shown in FIGS. 4 and 5, by combining a plurality of patterns of the length of the flat portion of the bottom or top of the uneven structure, it is possible to adjust so that a desired stretched state is exhibited. For example, the second flat portion is set to have the same length, and the length of the first flat portion is changed periodically or randomly in a predetermined pattern along the direction in which the concave portions 2A and the convex portions 2B are arranged. Also good.

In the concave-convex structure 4, the concave portions 2A and the convex portions 2B are arranged linearly as shown in FIGS. It may be configured with an extended concave-convex pattern. The concave portion 2A and the convex portion 2B may be configured to have the same width, or may be configured to have different widths. The width in the extending direction of the concave portion 2A and the convex portion 2B may be set to change. The plan view is a schematic diagram showing the extending directions of the concave portion 2A and the convex portion 2B.
FIG. 7 shows an example in which the region 10 for forming the concave-convex structure 4 has a rectangular shape bounded by sides 10a and 10b, and the extending directions of the concave portions 2A and the convex portions 2B are set so as to be parallel to the short side 10b. be. That is, this is an example in which the concave-convex structure 4 is formed such that the concave portions 2A and the convex portions 2B are arranged in the direction of the long side 10a of the region 10 along the surface direction.

FIG. 8 shows an example in which the region 10 for forming the uneven structure 4 is rectangular, and the extending directions of the concave portions 2A and the convex portions 2B are set to be inclined from both the short side 10b and the long side 10a.
In the uneven structure 4, the recesses 2A and the protrusions 2B are arranged in such a manner that the recesses 2A and the protrusions 2B are formed as shown in FIGS. At least a part of the extending direction of 2B may be configured with a concavo-convex pattern configured with curved lines. The concave portion 2A and the convex portion 2B may be configured to have the same width, or may be configured to have different widths.

FIG. 9 shows an example in which the region 10 for forming the concave-convex structure 4 has a rectangular shape, and the extending directions of the concave portions 2A and the convex portions 2B are set concentrically.
FIG. 10 shows an example in which the region 10 forming the concave-convex structure 4 is rectangular, and the extending directions of the concave portions 2A and the convex portions 2B are concentric and elliptical (similar elliptical shapes).
In FIG. 11, the area 10 for forming the uneven structure 4 is rectangular, and the extending directions of the concave portions 2A and the convex portions 2B are set to be parallel to the short sides, and meandering along the extending direction. This is an example of setting to the state.
In addition, the above uneven pattern is an example, and is not limited to these shapes.

For example, in one region 10, the basic extending directions of the concave portion 2A and the convex portion 2B are linear, and a portion extending along a curved line is provided. may be set to a mixed pattern shape.
Moreover, although the rectangular shape was illustrated also about the area|region 10 which forms the uneven|corrugated structure 4, the shape of the area|region 10 is not limited to rectangular shape. The contour of the region 10 may be circular or the like.
Moreover, it is not necessary to make the entire surface of the patch support film 1 the area 10 where the uneven structure 4 is provided. For example, there may be portions where the concave-convex structure 4 is not formed, such as the edge portions on both the left and right sides in FIG. In the case of FIG. 7, the stretchability is increased in the left-right direction, so if the stretchability is not constrained, even if the patch support film 1 partially lacks the uneven structure 4, No problem.

(Thickness of adhesive backing film 1, height of irregularities, etc.)
The total thickness T of the adhesive backing film 1 is 10 μm or more and 450 μm or less (see FIG. 6). The total thickness T is more preferably 10 μm or more and 300 μm or less. The film thickness of the adhesive backing film 1 does not necessarily have to be uniform. In the film after uneven shape processing, the thickness of the adhesive backing film 1 in the vicinity of the ridge line 2D (near the connecting portion of the two portions facing in different directions) is the same as the thickness of the adhesive backing film 1 in the other portions. It may be different from the thickness.

The film thickness of the adhesive backing film 1 is 5 μm or more and 150 μm or less. FIG. 6 illustrates a case where the top flat portion 2Ba is the first flat portion and the bottom flat portion 2Aa is the second flat portion. The difference between the film thickness t2 of the bottom flat portion 2Aa and the film thickness t1 of the top flat portion 2Ba is preferably 5% or more and 65% or less of the film thickness of the first flat portion. When the film thickness of the first flat portion has a predetermined range, the maximum value of the film thickness of the first flat portion is used as a reference.

If the thickness of the adhesive backing film is less than 5 μm, the required strength cannot be maintained, and there is a risk that the adhesive will be easily broken. If the thickness of the adhesive backing film is more than 150 μm, the stress required for deformation of the uneven structure will be too large, possibly deteriorating elongation. By providing a difference in film thickness between the bottom flat portion 2Aa and the top flat portion 2Ba of the uneven structure 4, that is, by providing a thick portion and a thin portion, the thin portion improves the extensibility and the thick portion reduces the strength. It is possible to obtain a patch support film that contributes to retention, is resistant to breakage, and exhibits good elongation.

The height difference H between the concave portions 2A and the convex portions 2B of the concave-convex structure 4 is preferably in the range of more than 5 μm and 300 μm or less. When the height difference H between the concave portion 2A and the convex portion 2B is 5 μm or less, it is difficult to obtain the effect of adjusting the strain. There is More preferably, the height difference H is within the range of 10 μm or more and 200 μm or less.
The film thickness t1 of the top flat portion 2Ba, the film thickness t2 of the bottom flat portion 2Aa, the total thickness T, and the height difference H were measured at five locations each in a cross section observed with an optical microscope with a CCD, and averaged. I decided to take a value.
The concave-convex structure 4 is preferably a periodic structure in which concave portions 2A and convex portions 2B are regularly arranged. By avoiding a random structure, it is easy to obtain the intended elongation, and at the same time, it is possible to simplify the design and manufacture of the concave-convex structure 4 . However, it is optional to randomly change the width of the uneven structure 4 or partially change the width of the uneven structure 4 .

(Effect and others)
In general, plastic films having drug barrier properties have relatively high strength but low elongation. Therefore, when the film is composed of the flat patch support film 1 without the concave-convex structure 4 as in the present embodiment, the elongation behavior of the film is as shown by reference numeral 20 in FIG. Elastic deformation occurs only in a short distance after the beginning of elongation, and the yield point is soon reached (hereafter, the starting point at which necking begins is called the yield point). After the yield point, plastic deformation accompanied by necking occurs, and when the breaking point is reached, the film breaks.

On the other hand, the patch support film 1 of the present embodiment is pulled, for example, in the left-right direction of FIG. In this case, the adhesive backing film 1 first undergoes shape deformation due to elastic deformation, and then undergoes plastic deformation in part of the shape deformation. If it continues to be pulled further, the tensile stress reduces the height difference of the concave-convex structure 4, and the uneven structure 4 becomes closer to being flat, so that the shape cannot be deformed. That is, the stage where the uneven structure is mainly crushed and spread (the area that stretches without applying much force) and the stage where the collapsed uneven structure is further stretched and becomes almost flat (the area that stretches when force is applied), and the yield point , and eventually necking occurs and breaks.

As shown in FIG. 18, the adhesive backing film 1 of the present embodiment undergoes such multi-stage shape deformation, resulting in a higher elongation than the conventional adhesive backing film until it reaches the yield point, as shown in FIG. Higher volume and less stress required for elongation. Therefore, the adhesive backing film 1 of the present embodiment has a large elongation until necking occurs, and has the property of being easily elongated. This indicates that the strength of the adhesive backing film 1 can be lowered.

In the present embodiment, the flat portion has a flat portion with a thick film thickness and a flat portion with a thin film thickness, so that the adhesive backing film exhibits excellent elongation and is difficult to break.
Here, the thinner the thickness of the adhesive backing film 1 is, the smaller the stress required when the uneven structure is deformed, that is, when the adhesive backing film 1 is stretched, and the stretchability is improved. lead to decline. Conversely, as the thickness of the adhesive backing film 1 increases, the strength improves, but the stress required for elongation of the adhesive backing film 1 increases, leading to deterioration in stretchability.
On the other hand, in the present embodiment, on the premise of the concave-convex structure 4 exhibiting extensibility by the action as described above, the bottom flat portion 2Aa and the top flat portion 2Ba of the concave-convex structure are provided with a film thickness difference. . That is, the film thickness of a part of the flat portions (first flat portion) among the plurality of flat portions is reduced.

In this case, the strength of the adhesive backing film is ensured by the second flat portion having a relatively thick film thickness, and the film thickness is partially thinned by the first flat portion so that the thin portion The stretchability of the adhesive backing film having the concave-convex structure is improved by having a portion where the concave-convex structure is easily deformed. In addition, by partially thinning the film thickness of a portion of the flat portion, the strength of the adhesive backing film is secured, while the flexibility of the adhesive backing film as a whole is improved. As a result, the adhesiveness of the adhesive backing film is improved.

Here, when the patch support film is pulled and the concave-convex structure is deformed, the ridge line 2D (joint position between the flat portion and the columnar portion 2C) where stress tends to concentrate is likely to be cut. At this time, even if a first flat portion having a relatively thin film thickness is provided, when the flat portion adjacent to the first flat portion is used as the second flat portion, the first flat portion and the second flat portion are formed. It becomes easy to adjust the film thickness of the columnar portion 2C connecting one flat portion and the adjacent second flat portion to the thickness corresponding to the second flat portion. In this case, even if the first flat portion is provided, the film thickness of the columnar portion 2C connected to the first flat portion is not so thin, so that the ridge line 2D is prevented from becoming easily cut. Even if the flat portion adjacent to the first flat portion is also the first flat portion, if the film thickness of the column portion 2C that connects the two is increased, it is possible to suppress the ease of cutting at the ridgeline 2D. It is possible to form easily by using one flat portion as the second flat portion as shown in FIG.

As described above, even if the adhesive backing film 1 is made of a material that is generally considered to have low extensibility, the adhesive backing film 1 can be made to have high extensibility by devising the shape. can be given. In other words, both strength and elongation of the adhesive backing film 1 having drug barrier properties can be achieved.
At this time, by appropriately controlling the cross-sectional shape of the patch support film 1, arbitrary elongation can be obtained. For example, when it is desired to stretch the film greatly without breaking it, the height difference H of the uneven structure 4 is increased, and the ridgeline 2D (corner), which is the connecting portion between the two portions facing in different directions, is rounded. It is better to make adjustments such as not to

The adhesive backing film 1 according to the present embodiment can improve extensibility by changing the shape of the adhesive backing film 1 at the initial stage of stretching. In other words, the film is not stretched by the material itself stretching from the initial stage of pulling, unlike the adhesive backing film 1 having a normal flat surface. When the adhesive backing film 1 according to the present embodiment is pulled in the direction in which the uneven structure 4 is arranged, local distortion (elongation or shrinkage) occurs in the uneven structure 4 of the adhesive backing film 1 at the beginning of the pulling. is generated, resulting in a change in shape, so that a large elongation can be obtained. Therefore, by appropriately setting the shape of the concave-convex structure 4, the elongation of the entire film can be freely adjusted.

(Relationship Between Elongation of Patch Backing Film 1 and Maximum Value of Local Strain)
FIG. 19 shows the relationship between the total elongation and the maximum value of local strain when the shape of the concave-convex structure 4 of the adhesive backing film 1 is changed. The vertical axis is the maximum value of local strain, and the horizontal axis is the elongation of the entire film. A comparative example is an adhesive patch support film that does not have the concave-convex structure 4 indicated by dotted lines (no shape).
FIG. 20 shows the cross-sectional shape of the adhesive backing film 1 having high extensibility used in the evaluation shown in FIG. Shape A shown in FIG. 20A has a relatively large height difference H between recesses 2A and protrusions 2B of the uneven structure 4, and shape B shown in FIG. The height difference H of 2B is relatively small. and. It can be seen that the relationship between the overall elongation and the maximum value of local strain varies greatly depending on the uneven structure 4 of the patch support film 1 having high elongation of the present embodiment.

For example, by making the height difference H between the concave portions 2A and the convex portions 2B of the concave-convex structure 4 relatively large as in the shape A in FIG. 20(a), as shown in FIG. can be smaller than the local distortion. In the patch support film 1 adopting the shape A, cracks such as rupture are less likely to occur in the film itself. In addition, for example, even if a hard functional layer is laminated on the surface (for example, deposition, hard coating, etc.) and pulled, the hard functional layer can be prevented from cracking. This is because the hard functional layer is loaded by the above-described local strain. In other words, by applying the patch support film 1 adopting the shape A to, for example, a laminate in which functional layers are laminated, breakage of the hard functional layers can be suppressed and extensibility can be imparted.

In shape B in FIG. 20(b), the height difference H between the concave portions 2A and the convex portions 2B of the concave-convex structure 4 is relatively small. In this case, as shown in FIG. In some cases, the local strain may be greater than the elongation of the However, the elongation of the film as a whole is large and exhibits high elongation compared to the unshaped film. These concave-convex structures 4 may be optimized in consideration of the desired extensibility and strength of the adhesive backing film 1, or the materials and forms of the functional layers to be laminated. For example, by optimizing using the general-purpose nonlinear finite element analysis solution Marc (registered trademark), it is possible to obtain the desired practical patch support film 1 .
Furthermore, in order to increase stretchability, the height difference H of the uneven structure 4 should be adjusted according to the film thickness of the patch support film 1 It is preferably larger than the average value of the film thickness t2 (see FIG. 6). By doing so, the cross section of the adhesive backing film 1 is less likely to become flat, and the effect of adjusting distortion can be effectively obtained.

(Characteristics of adhesive backing film 1)
In addition, the adhesive backing film 1 of the present embodiment, which has high elongation, has the effect of elongating when stress is applied, so it has high impact resistance, and also has high impact absorption when the uneven structure 4 is crushed. also have
Furthermore, when the uneven structure 4 is a one-dimensional structure as shown in FIG. 1, there is also a property that the flexural rigidity is high in the extension direction of the unevenness (in FIG. 1, the paper surface direction). Bending stiffness is determined by the integral of the product of the geometrical moment of inertia and Young's modulus. Since the adhesive backing film 1 of the present embodiment having high extensibility has a larger geometrical moment of inertia than a normal adhesive backing film 1 having the same amount of resin, the flexural rigidity is increased.

(Manufacturing method of adhesive backing film 1)
As for the method for producing the patch support film 1 having high extensibility of the present embodiment, for example, a production method by hot pressing or a production method by extrusion molding can be used.
In the hot press method, the film can be produced by passing the formed film between a pair of heating rolls having an uneven surface or through a pair of heated plate-like pressing machines. At this time, it is important that the upper and lower concave and convex shapes between a pair of heating rolls or a pair of flat plates are precisely aligned so that the surface of the film after hot pressing has a continuous uneven structure. becomes.
In the extrusion molding method, the resin is heated and melted, extruded from a T-die, and cooled while applying nip pressure using a cooling roll and a nip roll provided with an uneven shape in the cooling process for film formation. Thus, a continuous concave-convex structure can be provided on the front and back surfaces of the film. This method also requires precise alignment of the uneven shapes of the cooling roll and the nip roll.

Alternatively, in another method of extrusion molding, a multi-layer film having two or more layers can be obtained by coextrusion of multiple types of resins by a feed block method or a multi-manifold method using a plurality of extruders. In the cooling process for forming a film, a continuous uneven structure can be provided on the front and back surfaces of the film by cooling while applying nip pressure using a cooling roll having an uneven shape. Furthermore, at this time, when the height difference H of the uneven structure is large with respect to the film thickness t of the first resin layer in contact with the cooling roll, a similar uneven structure is formed at the interface between the first resin layer and the second resin layer. Therefore, by peeling off the second resin layer from the multilayer film after cooling, the first resin layer having the uneven structure on the front and back surfaces is obtained, and this can be used as the adhesive backing film 1 . .
In addition, it is possible to manufacture the patch support film 1 by appropriately selecting various methods such as casting molding, inflation molding, calender molding, etc., and the manufacturing method is not particularly limited.

(Laminate)
As shown in FIG. 14, the adhesive backing film 1 having high extensibility has a printing layer, a vapor deposition layer, a hard coat layer, and an antireflection layer on the surface 3 of the side on which the drug-containing pressure-sensitive adhesive layer is not provided in a post-process. It is also possible to form a laminate in which functional layers 30 such as the above are laminated.
FIG. 17 shows a schematic cross-sectional view of a common patch. In this general example, an adhesive layer 6 containing a drug is provided on one side of an adhesive backing film 8 , and a release liner 7 is provided on the surface of the adhesive layer 6 . When sticking to the skin, the release liner is peeled off and the pressure-sensitive adhesive layer 6 is stuck to the skin. Then, the drug contained in the adhesive layer 6 is absorbed through the skin and acts.
Such a general adhesive patch support film 8 lacks extensibility, and the adhesive patch may feel stiff after being applied to the skin. However, there is a problem that it may peel off.

On the other hand, by using the patch support film 1 or the laminate of the present embodiment, elasticity can be imparted, and the above-mentioned stiff feeling and peeling can be eliminated.
As an example, FIGS. 15 and 16 show cross-sectional views of a patch 9 using the patch support film 1 of the present embodiment. In this embodiment, by using a material with high drug barrier property, the effect of efficiently absorbing the drug into the skin is obtained. Extensible.

(Another embodiment of patch support film 1)
As shown in FIGS. 12 and 13, the patch support film 12 may have a plurality of areas 10, and each area 10 may have the uneven structure 4 formed in an individual uneven pattern.
12 and 13 show the case where a series of adhesive backing films 1 are divided into a plurality of sections to set a plurality of regions 10 (FIGS. 12 and 13 are examples of division into four regions 10). , and the extending direction of the uneven structure 4 is indicated by a solid line. Reference numeral 10c indicates the boundary between adjacent boundary lines 10. FIG.

In FIG. 12, the extending direction of the concave-convex structure 4 is parallel to the edge of each section and orthogonal to the extending direction of the concave-convex structure 4 in the adjacent section. A film with good elongation has the problem that the film stretches during processing, making it difficult to form a stable film. Then, by cutting or punching each section, it is possible to provide the patch support film 1 that extends in one desired direction. There may be no clear boundaries between adjacent sections, and the number and size of sections existing on the series of adhesive backing film 1 can be set arbitrarily. Further, regions 10 having no concave-convex structure 4 may exist between the regions 10 .

The cutting position can also be arbitrarily set. For example, in the arrangement shown in FIG. A partitioned patch carrier film 1 can be obtained. In this case, it is effective when one half of the film is to be fixed and only the other half is to be stretched or contracted. That is, it may be designed such that a plurality of regions 10 constitute one final product. In this case, when the patch is to be applied to the skin, it is also possible to first apply and fix the non-stretchable half of the film to the skin and stretch the remaining half to apply.

In the patch support film 1 shown in FIG. 13, the angled uneven structure 4 extends straight from one side of each region 10 to the other side that intersects with the region 10 . Other configurations are the same as those of the adhesive backing film 1 shown in FIG. The angle of the uneven structure 4 with respect to the boundary line 10c that divides the regions 12 is arbitrary, and the angle may be different for each region 10 .

(Effect of this embodiment)
(1) The adhesive backing film 1 of the present embodiment can have the drug-containing pressure-sensitive adhesive layer 6 disposed on one side 2, and the entire backing adhesive patch film 1 is configured in a undulating shape in the film thickness direction. As a result, it has an uneven structure 4 in which the concave portions 2A and the convex portions 2B are repeated along the surface. The bottom of the concave portion 2A and the top of the convex portion 2B are flat portions with a flat cross section, the film thickness of the flat portion is in the range of 5 μm or more and 150 μm or less, and a part of the flat portion is flat. The film thickness of the first flat portion that is the portion is thinner than the film thickness of the second flat portion that is the flat portion other than the first flat portion, and the total thickness of the adhesive backing film is 10 μm or more and 450 μm or less. Range.

According to this configuration, it is possible to provide the adhesive backing film 1 having a simple structure, ensuring the strength as a backing, and having both good drug barrier properties and extensibility, while suppressing labor and cost in manufacturing. .
For example, in the patch support film 1 of the present embodiment, even if the patch support film 1 is formed from a film having drug barrier properties, the provision of the concave-convex structure 4 can improve stretchability. At this time, a film thickness difference is provided between the film thickness t2 of the bottom flat portion 2Aa and the film thickness t1 of the top flat portion 2Ba of the concave-convex structure. Since the thick portion contributes to securing the strength, it is possible to impart the required strength to the adhesive backing film 1 while securing the above elongation.

(2) The patch support film 1 of the present embodiment is made of any one of polyethylene terephthalate, cycloolefin copolymer, cycloolefin polymer, polyacrylonitrile, ethylene-vinyl alcohol copolymer, and modified polymers thereof. Consists of selected resins.
According to this configuration, the adhesive backing film 1 can be provided with drug barrier properties.

(3) In the patch support film 1 of the present embodiment, the concave portions 2A and the convex portions 2B each extend linearly in plan view.
According to this configuration, the elongation in the direction in which the unevenness is arranged can be reliably increased, and the bending configuration in the extending direction of the unevenness can be set high.

(4) In the adhesive patch support film 1 of the present embodiment, at least a part of the extending direction of the concave portions 2A and the convex portions 2B is curved in plan view.
According to this configuration, the elongation in the direction in which the unevenness is arranged can be reliably increased, and the bending configuration in the extending direction of the unevenness can be set high.
In addition, by providing a curve in the extension direction in at least a part, for example, by forming a curve in consideration of the direction in which the body bends, it is possible to follow the change of the body at the position where it is attached. has the advantage of increasing

(5) In the patch support film 1 of the present embodiment, the height difference of the unevenness is more than 5 μm and 300 μm or less. According to this configuration, it is possible to reliably improve extensibility.
(6) In the patch support film 1 of the present embodiment, the irregularities are arranged periodically such as at regular intervals. According to this configuration, it becomes easier to set the extensibility.
(7) In the patch support film 1 of the present embodiment, the intervals between the irregularities are aperiodic.
According to this configuration, by narrowing the pitch of the portion that bends more and widening the pitch of the portion that bends less, it is possible to control the elongation of the patch in accordance with the movement of the body. There is an advantage that the followability is improved in the part where the feeling of unevenness of the body changes greatly, such as the vicinity of the shoulder blade.

(8) The patch support film 1 of the present embodiment has a plurality of regions 10, and each region 10 is formed with the uneven structure 4 in a separate uneven pattern.
In this configuration, when used as the original film of the final product, the elongation of each region 10 is offset to some extent, and excessive elongation is suppressed, and when the film is managed in a roll shape or the like, the adhesive patch is used. Handling of the support film 1 is facilitated.
In addition, when used as the adhesive backing film 1 of the final product, it becomes easy to set two or more directions in which it is easy to stretch.

(9) A laminate in which functional layers are laminated on both sides or one side of the patch support film 1 of the present embodiment may be used. According to this configuration, it is possible to provide a laminate having good extensibility.
(10) In the patch of the present embodiment, a pressure-sensitive adhesive layer 6 is laminated on one side of the support layer of the patch support film 1 or laminate, and a release liner 7 is laminated on the pressure-sensitive adhesive layer 6 . is formed. According to this configuration, it is possible to provide a patch having both good drug barrier property and elongation while ensuring strength as a backing with a simple structure while suppressing labor and cost in manufacturing.
Although the embodiments of the present invention have been exemplified above, it goes without saying that the present invention is not limited to the above embodiments. Moreover, it is arbitrary to combine and use the above embodiments.

EXAMPLES Examples based on the present invention will be described below, but the present invention is not limited to the following examples.
(Example 1)
As a material for the patch support film 1, ethylene-vinyl alcohol copolymer (EVOH) Soarnol D2908 (manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) was used.
The adhesive backing film 1 of Example 1 was provided with an embossed structure 4 having a trapezoidal bellows cross section as shown in FIG. At this time, the size of each part of the structure is: total thickness T=92 μm, length of top flat portion 2Ba=205 μm, film thickness of top flat portion 2Ba=30 μm, length of bottom flat portion 2Aa=224 μm, bottom flat portion 2Aa. The film thickness t2 was 32 μm, the pitch between the concave portion 2A and the convex portion 2B was 255 μm, and the height difference H was 60 μm.

(Example 2)
A patch support film 1 of Example 2 was produced in the same manner as in Example 1, except that the total thickness T was changed to 109 μm, the film thickness of the flat bottom portion 2Aa was changed to 49 μm, and the height difference H was changed to 60 μm.
(Example 3)
The size of each part of the uneven structure 4 is as follows: total thickness T = 31 µm, length of top flat portion 2Ba = 68 µm, film thickness t1 of top flat portion 2Ba = 10 µm, length of bottom flat portion 2Aa = 75 µm, length of bottom flat portion 2Aa. A patch support film 1 of Example 3 was produced in the same manner as in Example 1, except that the film thickness t2 was changed to 11 μm, the pitch between the concave portions 2A and the convex portions 2B was changed to 85 μm, and the height difference H was changed to 20 μm. .

(Example 4)
A patch support film 1 of Example 4 was produced in the same manner as in Example 3, except that the total thickness T was changed to 36 μm and the film thickness of the flat bottom portion 2Aa was changed to 16 μm.
(Example 5)
The size of each part of the uneven structure 4 is as follows: total thickness T = 355 µm, length of top flat portion 2Ba = 820 µm, film thickness t1 of top flat portion 2Ba = 90 µm, length of bottom flat portion 2Aa = 896 µm, length of bottom flat portion 2Aa. A patch support film 1 of Example 5 was produced in the same manner as in Example 1, except that the film thickness t2 was changed to 145 μm, the pitch between the concave portions 2A and the convex portions 2B was changed to 950 μm, and the height difference H was changed to 210 μm. .
(Example 6)
Example 6 was fabricated in the same manner as in Example 5 except that the total thickness T was changed to 390 μm, the film thickness t1 of the flat top portion 2Ba was 140 μm, the film thickness t2 of the flat bottom portion 2Aa was 147 μm, and the height difference H was changed to 243 μm. was prepared.

(Comparative example 1)
Using a mirror-finished roll having no irregularities during extrusion molding, a patch support film of Comparative Example 1 having no irregularities on the front and back surfaces was produced. The total film thickness was 30 μm.
(Comparative example 2)
The size of each part of the uneven structure 4 is as follows: total thickness T = 12 µm, length of top flat portion 2Ba = 27 µm, film thickness t1 of top flat portion 2Ba = 3 µm, length of bottom flat portion 2Aa = 30 µm, length of bottom flat portion 2Aa. A patch support film of Comparative Example 2 was prepared in the same manner as in Example 1, except that the film thickness t2 was 4 μm, the pitch was 34 μm, and the height difference H was 8 μm.

(Comparative Example 3)
The size of each part of the uneven structure 4 is as follows: total thickness T = 510 µm, length of top flat portion 2Ba = 513 µm, film thickness t1 of top flat portion 2Ba = 100 µm, length of bottom flat portion 2Aa = 560 µm, length of bottom flat portion 2Aa. A patch support film of Comparative Example 3 was prepared in the same manner as in Example 1, except that the film thickness t2 was 150 μm, the pitch between the concave portions 2A and the convex portions 2B was 637 μm, and the height difference H was 360 μm.
(Comparative Example 4)
A patch support film of Comparative Example 4 was prepared in the same manner as in Example 1, except that the total thickness T was 70 μm, the film thickness t1 of the flat top portion 2Ba was 10 μm, and the film thickness t2 of the flat bottom portion 2Aa was 10 μm. made.

(Comparative Example 5)
The size of each part of the uneven structure 4 is as follows: total thickness T = 250 µm, length of top flat portion 2Ba = 513 µm, film thickness t1 of top flat portion 2Ba = 100 µm, length of bottom flat portion 2Aa = 560 µm, length of bottom flat portion 2Aa. A patch support film of Comparative Example 5 was prepared in the same manner as in Example 1 except that the film thickness t2 was 100 μm, the pitch between the concave portions 2A and the convex portions 2B was 637 μm, and the height difference H was 150 μm.
(Comparative Example 6)
A patch support film of Comparative Example 6 was prepared in the same manner as in Example 1, except that the arrangement of the uneven structures 4 was non-parallel.
(Comparative Example 7)
A patch support film of Comparative Example 7 was prepared in the same manner as in Example 1 except that polylactic acid (PLA) Ingeo 3052D (manufactured by NatureWorks) was used as the material of patch support film 1 .

(Length measurement method)
The total thickness T, the film thickness t1 of the top flat portion 2Ba, the film thickness t2 of the bottom flat portion 2Aa, and the height difference H of each sample obtained were confirmed by length measurement by optical microscope observation. Specifically, by cutting the obtained adhesive backing film in directions parallel and perpendicular to the extending direction of the concave-convex structure 4, a small piece of 10 mm square is cut out, and the cross-section is observed with a microtome. Then, the size of each part was measured, and the average value of the five parts was obtained. A digital microscope VHX-1000 (manufactured by KEYENCE CORPORATION) equipped with a dual light high-magnification zoom lens VH-Z250R was used for cross-sectional observation and length measurement.
Also, the film thickness difference between the film thickness t1 of the top flat portion 2Ba and the film thickness t2 of the bottom flat portion 2Aa was obtained as a ratio to the film thickness t1 of the top flat portion 2Ba.

(Elongation evaluation method)
In order to evaluate the elongation performance of the adhesive backing film 1 of each example and comparative example, a tensile test evaluation was performed.
The elongation evaluation is based on JISK7127:1999, using a Tensilon universal material testing machine RTC-1250A (manufactured by A&D Co., Ltd.), while applying a tensile force from a zero state until the film breaks. The amount of elongation from the state to the yield point (hereinafter referred to as yield point elongation) and the breaking strength at the time of breakage were determined. As for the measurement conditions, the sample width was 15 mm, the distance between chucks was 50 mm, and the tensile speed was 100 mm/min.
For the evaluation, a breaking strength of 3 N or more was evaluated as "○", and a strength of less than 3 N was evaluated as "X".
In addition, the elongation at yield point of 20% or more was evaluated as "○", and less than that as "X".

(Drug adsorption evaluation method)
In order to evaluate the drug adsorption performance of the adhesive backing film 1 having high extensibility in each of Examples and Comparative Examples, an adsorption test evaluation was carried out.
After cutting each sample of Examples and Comparative Examples into 100 mm squares, a patch (Rivatouch patch 18 mg, manufactured by Ono Pharmaceutical Co., Ltd.) was applied to the center of each sample. It was sealed with aluminum foil so that the chemical would not volatilize and diffuse, and was stored in an environment of 40° C. and 75% for 6 months. Thereafter, the patch was peeled off from the film, the drug adsorbed on the film was extracted with methanol at 55°C for 3 hours or longer, and the amount of drug adsorbed was measured by high performance liquid chromatography (HPLC).
For the evaluation, the amount of drug adsorbed was rated as "O" if it was less than 10% of the drug amount of the original patch, and as "X" if it was more than that.
Tables 1 and 2 show the conditions and evaluation results in each example and comparative example.

(Evaluation results)
As can be seen from Table 1, Examples 1 to 6 based on the present invention exhibited good breaking strength, and the yield point elongation was also found to exhibit a large value compared to the flat film of Comparative Example 1. .
On the other hand, in Comparative Example 2, since the thickness of the film was too thin, the breaking strength was small and the requirements were not met together with the yield point elongation.
In Comparative Example 3, the film thickness of the bottom flat portion 2Aa (the thicker one of the flat portion film thicknesses of the concave portion 2A and the convex portion 2B) was too thick, resulting in poor elongation at yield point.
In Comparative Example 4, the film thickness of the flat portion is the same between the concave portion 2A and the convex portion 2B, and the breaking strength is small due to the thin film thickness, which does not satisfy the requirements.

In Comparative Example 5, the film thickness of the flat portions was the same between the concave portion 2A and the convex portion 2B, resulting in poor yield point elongation depending on the film thickness.
In Comparative Example 6, the extending directions of the irregularities were non-parallel, and the intersection of the structures hindered the elongation due to the deformation of the irregularities of the adhesive backing film 1, resulting in poor elongation at yield point.
In Comparative Example 7, the material of the backing layer exhibited drug adsorption properties, so the results did not satisfy the requirements for the patch backing film 1 .

In Tables 1 and 2, only the film thickness of the flat top portion 2Ba<the film thickness of the flat bottom portion 2Aa is described, but the film thickness of the flat bottom portion 2Aa<the film thickness of the flat top portion 2Ba and the flat top portion Even if there are portions where the film thickness of the portion 2Ba<the film thickness of the flat bottom portion 2Aa and the portion where the film thickness of the flat bottom portion 2Aa<the film thickness of the flat top portion 2Ba coexist, the film thickness of each portion is the predetermined film thickness. It has been confirmed that within the range, it was possible to obtain a patch support film that similarly exhibits good breaking strength and is also excellent in yield point elongation.

1 Adhesive backing film 2A Concave portion 2Aa Bottom flat portion 2B Convex portion 2Ba Flat top portion 2C Column portion 2D Edge line 4 Concavo-convex structure 6 Adhesive layer

Claims (13)

A patch support film made of a resin having drug barrier properties,
The patch support film has an uneven structure in which concave portions and convex portions are repeated along the surface by forming the entire layer in a undulating shape in the film thickness direction,
In the uneven structure, the height difference between the recesses and the protrusions is greater than the film thickness of the patch support film,
The bottom portion of the concave portion and the top portion of the convex portion are flat portions having a flat cross section, and the film thickness of the flat portion is in the range of 5 μm or more and 150 μm or less, and the flat portion is a part of the flat portion. the film thickness of a certain first flat portion is thinner than the film thickness of a second flat portion which is a flat portion other than the first flat portion;
The adhesive backing film has a total thickness of 10 μm or more and 450 μm or less,
The adhesive backing film , wherein the first flat portion is present in both the flat portion forming the bottom portion and the flat portion forming the top portion. 2. The patch support film according to claim 1, wherein a flat portion adjacent to the first flat portion in the direction in which the concave portions and the convex portions are arranged is the second flat portion. 2. A film thickness difference between the film thickness of the first flat portion and the film thickness of the second flat portion is 5% or more and 65% or less of the film thickness of the first flat portion. The adhesive backing film according to claim 2. The adhesive patch according to any one of claims 1 to 3, wherein the first flat portion is either the flat portion constituting the bottom portion or the flat portion constituting the top portion. support film. The resin having drug barrier properties is composed of a resin selected from polyethylene terephthalate, cycloolefin copolymer, cycloolefin polymer, polyacrylonitrile, ethylene-vinyl alcohol copolymer, and modified polymers thereof. The adhesive backing film according to any one of claims 1 to 4 , wherein 6. The concave portion and the convex portion each extend linearly and in parallel in a plan view on the surface side made of the resin having the drug-barrier properties. 1. The adhesive backing film according to item 1. In a plan view, the concave portion and the convex portion extend parallel to each other on the surface side made of the resin having the drug-barrier property, and at least a part of the extending direction is configured with a curved line. The adhesive backing film according to any one of claims 1 to 6 . The adhesive backing film according to any one of claims 1 to 7 , wherein the height difference is more than 5 µm and not more than 300 µm. 9. The patch support film according to any one of claims 1 to 8 , wherein the arrangement of the concave portions and the convex portions has periodicity. 9. The adhesive backing film according to any one of claims 1 to 8 , wherein the arrangement of the concave portions and the convex portions is aperiodic. 11. The adhesive backing film according to any one of claims 1 to 10 , which has a plurality of areas, each area being formed with an individual uneven pattern. A laminate obtained by laminating a functional layer on one or both sides of the patch support film according to any one of claims 1 to 11 . A drug-containing pressure-sensitive adhesive layer and a release liner are arranged in this order on the side of the drug-barrier resin layer of the adhesive backing film of any one of claims 1 to 11 or the laminate of claim 12 . Formed patch.

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