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JP7308034B2 - 最適化二重ヌクレアーゼ融合物および方法 - Google Patents

最適化二重ヌクレアーゼ融合物および方法 Download PDF

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JP7308034B2
JP7308034B2 JP2018569138A JP2018569138A JP7308034B2 JP 7308034 B2 JP7308034 B2 JP 7308034B2 JP 2018569138 A JP2018569138 A JP 2018569138A JP 2018569138 A JP2018569138 A JP 2018569138A JP 7308034 B2 JP7308034 B2 JP 7308034B2
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polypeptide
amino acid
domain
seq
acid sequence
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JP2019530430A5 (fr
JP2019530430A (ja
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ジェイムズ アーサー ポサダ，
サンジェイ パテル，
ウェイホン ユー，
クリス ガベル，
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リゾルブ セラピューティクス， エルエルシー
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Neurology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
JP2018569138A 2016-07-01 2017-06-30 最適化二重ヌクレアーゼ融合物および方法 Active JP7308034B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022122570A JP2022153588A (ja) 2016-07-01 2022-08-01 最適化二重ヌクレアーゼ融合物および方法
JP2023208402A JP2024026334A (ja) 2016-07-01 2023-12-11 最適化二重ヌクレアーゼ融合物および方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662357756P 2016-07-01 2016-07-01
US62/357,756 2016-07-01
PCT/US2017/040267 WO2018005954A2 (fr) 2016-07-01 2017-06-30 Fusions de binucléase optimisées.

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JP2022122570A Division JP2022153588A (ja) 2016-07-01 2022-08-01 最適化二重ヌクレアーゼ融合物および方法

Publications (3)

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JP2019530430A JP2019530430A (ja) 2019-10-24
JP2019530430A5 JP2019530430A5 (fr) 2020-08-06
JP7308034B2 true JP7308034B2 (ja) 2023-07-13

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JP2018569138A Active JP7308034B2 (ja) 2016-07-01 2017-06-30 最適化二重ヌクレアーゼ融合物および方法
JP2022122570A Pending JP2022153588A (ja) 2016-07-01 2022-08-01 最適化二重ヌクレアーゼ融合物および方法
JP2023208402A Pending JP2024026334A (ja) 2016-07-01 2023-12-11 最適化二重ヌクレアーゼ融合物および方法

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JP2022122570A Pending JP2022153588A (ja) 2016-07-01 2022-08-01 最適化二重ヌクレアーゼ融合物および方法
JP2023208402A Pending JP2024026334A (ja) 2016-07-01 2023-12-11 最適化二重ヌクレアーゼ融合物および方法

Country Status (10)

Country Link
US (4) US20190241878A1 (fr)
EP (2) EP3478830B1 (fr)
JP (3) JP7308034B2 (fr)
CN (2) CN119120423A (fr)
AU (2) AU2017290389B2 (fr)
CA (1) CA3029627A1 (fr)
DK (1) DK3478830T3 (fr)
HR (1) HRP20240603T1 (fr)
MA (1) MA45554A (fr)
WO (1) WO2018005954A2 (fr)

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SG10201912571XA (en) 2009-11-02 2020-02-27 Univ Washington Therapeutic nuclease compositions and methods
KR20250037576A (ko) 2011-04-29 2025-03-17 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 치료적 뉴클레아제 조성물 및 방법
WO2015066550A1 (fr) 2013-10-31 2015-05-07 Resolve Therapeutics, Llc Fusions nucléase-albumine à visée thérapeutique et procédés associés
US20190241878A1 (en) 2016-07-01 2019-08-08 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
CA3073537A1 (fr) 2017-08-22 2019-02-28 Sanabio, Llc Recepteurs d'interferon solubles et leurs utilisations
US20220089786A1 (en) * 2019-01-04 2022-03-24 Resolve Therapeutics, Llc Treatment of sjogren's disease with nuclease fusion proteins
US20230062096A1 (en) * 2020-01-11 2023-03-02 Yale University Compositions and methods for treating, ameliorating, and/or preventing diseases or disorders caused by or associated with dnase1 and/or dnase1l3 deficiency
AU2021288567A1 (en) * 2020-06-08 2023-02-09 Yale University Compositions and methods for treating and/or preventing coagulopathy and/or sepsis in patients suffering from bacterial and/or viral infections
CN112322607B (zh) * 2020-11-20 2023-03-28 江南大学 一种融合型腈水合酶及其应用
US12180521B2 (en) * 2021-02-19 2024-12-31 Theripion, Inc. Paraoxonase fusion polypeptides and related compositions and methods
WO2025147696A1 (fr) * 2024-01-05 2025-07-10 Resolve Therapeutics, Llc Traitement de symptômes associés à une infection virale au sars-cov ou à une infection virale au sars-cov antérieure avec des agents nucléasiques
US12416020B2 (en) 2024-02-20 2025-09-16 Wyvern Pharmaceuticals Inc. Plasmid encoding a TLR3 and Fc fusion protein

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JP2013509201A (ja) 2009-11-02 2013-03-14 ユニヴァーシティ オブ ワシントン 治療用ヌクレアーゼ組成物および方法
JP2014519809A (ja) 2011-04-29 2014-08-21 ユニヴァーシティ オブ ワシントン 治療用ヌクレアーゼ組成物および方法
JP2014533243A (ja) 2011-11-04 2014-12-11 ザイムワークス，インコーポレイテッド Ｆｃドメインにおける変異を有する安定なヘテロ二量体抗体デザイン
WO2015066550A1 (fr) 2013-10-31 2015-05-07 Resolve Therapeutics, Llc Fusions nucléase-albumine à visée thérapeutique et procédés associés

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AU2017290389B2 (en) 2024-09-26
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