JP7301291B2 - Catheter and oxygen partial pressure measurement method - Google Patents

Description

TECHNICAL FIELD The present invention relates to a catheter capable of measuring oxygen partial pressure and an oxygen partial pressure measuring method.

Acute Kidney Injury (AKI), which occurs in 30-50% of inpatients in the intensive care unit, has a negative impact on the prognosis of patients even if it is mild, making blood purification necessary. The mortality rate in cases is as high as 60%. In addition, transition to chronic renal failure is also a problem. Hypoxia in the renal medulla is one of the causes of AKI, and it is believed that the renal medulla oxygen partial pressure can be estimated by measuring the urinary oxygen partial pressure in the bladder. In order to measure the partial pressure of oxygen in urine in the bladder, a urinary catheter has been proposed in which an oxygen partial pressure measuring sensor protrudes from a side hole of the urinary catheter to measure the partial pressure of oxygen in the bladder or in the bladder wall. (See Patent Documents 1 and 2, for example).

Japanese Patent No. 2739880 WO2018/083487

However, in the above conventional urethral catheter, the oxygen partial pressure measuring sensor protrudes from the side of the catheter body. could not be measured properly.

In addition, since the path in the catheter body through which the oxygen partial pressure measurement sensor passes is bent near the tip of the catheter body, the oxygen partial pressure sensor is likely to be caught in this bent position, and the tip of the oxygen partial pressure sensor may be attached to the catheter body. It was difficult to protrude from the

In addition, even if the oxygen partial pressure measurement sensor is located on the tip side of the catheter body, if the opening hole at the tip of the catheter is only the side hole (horizontal hole), thrombus etc. may clog or urine may accumulate. It was difficult to measure the proper oxygen partial pressure.

SUMMARY OF THE INVENTION It is an object of the present invention to solve the above-described problems of the prior art and to provide a catheter capable of easily measuring oxygen partial pressure.

The present invention comprises a catheter body and a probe for measuring oxygen partial pressure, and the catheter body has a longitudinal hole (tipped hole) formed at its tip through which the probe can pass in the axial direction of the catheter body. characterized by being

In this case, the inner circumference of the longitudinal hole (tip hole) of the catheter may be the same as or shorter than the inner circumference of the channel of the catheter body. A lateral hole (side hole) may be formed in the vicinity of the distal end of the catheter body. The inner circumference of the longitudinal hole (tip hole) of the catheter body may be the same as or shorter than the inner circumference of the lateral hole (side hole).

Further, the present invention comprises a catheter body and a probe for measuring oxygen partial pressure, and the catheter body has a longitudinal hole at its tip through which the probe can pass in the axial direction of the catheter body. 1. A method for measuring partial pressure of oxygen using a catheter, comprising the steps of: inserting the catheter body into the bladder; and penetrating the probe through the longitudinal hole.

Further, the present invention comprises a catheter body and a probe for measuring the oxygen partial pressure, and the catheter body has a longitudinal hole at its tip through which the probe can pass in the axial direction of the catheter body. 1. A method for measuring oxygen partial pressure using a catheter, comprising the steps of: inserting into the bladder the catheter body in which the probe protrudes from the longitudinal hole; and measuring oxygen partial pressure in urine using the probe. , is characterized by having

Furthermore, the present invention comprises a catheter body and a probe for measuring the partial pressure of oxygen, and the catheter body has a longitudinal hole at its tip through which the probe can pass in the axial direction of the catheter body. Further, in the oxygen partial pressure measurement method using a catheter, the steps of inserting the catheter body into the bladder and measuring the oxygen partial pressure in urine flowing into the catheter body using the probe. characterized by having

The present invention can provide a catheter that can easily measure oxygen partial pressure.

FIG. 3 is a schematic diagram showing a state in which a urethral balloon catheter is inserted into the bladder; Fig. 2 is a front view showing the tip of the urethral balloon catheter; Fig. 2 is a cross-sectional view schematically showing the tip of a urethral balloon catheter; FIG. 10 is a schematic diagram showing a urethral balloon catheter according to a modification; FIG. 4 is a cross-sectional view schematically showing the tip of a urethral balloon catheter according to a modification;

A urethral balloon catheter according to one embodiment of the present invention will be described below with reference to the drawings.
FIG. 1 is a schematic diagram showing how a urethral balloon catheter is inserted into the bladder.

The urethral balloon catheter 100 includes a catheter body 10 and a probe 20, as shown in FIG.

The catheter main body 10 is formed in a tubular shape so that fluid can be circulated inside and the probe 20 can be passed through. Although the catheter body 10 according to the present embodiment is made of silicon rubber, it may be made of latex, natural rubber, isoprene rubber, thermoplastic resin such as PVC and urethane rubber, fluororubber and fluororesin. good. A balloon 12 is provided near the tip 11 of the catheter body 10 , and the catheter body is fixed in the bladder 30 by inflating the balloon 12 while being inserted into the bladder 30 .

The catheter body 10 is provided with a branch connector 17 . The branch connector 17 is made of silicone rubber, but may be made of latex, natural rubber, isoprene rubber, thermoplastic resin such as PVC and urethane rubber, fluororubber and fluororesin. Further, the branch connector 17 is provided with a conduit 17a through which the root portion of the probe 20 penetrates, a discharge conduit 17b for discharging urine 31 flowing from the bladder 30, and a gas or liquid such as air or sterilized water. A delivery line 17c is provided for delivery to inflate the balloon 12 . The delivery line may be equipped with a one-way valve to which a syringe can be connected. Further, the conduit through which the root portion of the probe 20 penetrates may have a function of adjusting the insertion depth of the probe 20 . As an adjustment function, for example, the depth of insertion of the probe 20 may be adjusted by a bellows type, a screw type (dial type), or by forming a circumferential rib on the pipeline.

The probe 20 incorporates a fluorescence optode (optical electrode) that measures the intensity of light emitted from a fluorescent dye that reacts with the urine 31 in the bladder 30, a dual fiber laser Doppler probe, and a temperature sensor. , the probe 20 is adapted to measure the partial pressure of oxygen in urine. Probe 20 may also be coated to reduce friction with the lumen of catheter body 10 . As the coating agent, any material that can reduce friction with the lumen of the catheter body 10, such as Teflon coat, parylene, or hydrophilic polymer, may be used. The lumen side of the catheter body 10 may be treated with the above-described coating agent.

The urethral balloon catheter 100 will be described in more detail below.
FIG. 2 is a front view showing the tip of the urethral balloon catheter, and FIG. 3 is a cross-sectional view showing the tip of the urethral balloon catheter. In FIG. 3, FIG. 3(a) shows how the probe 20 is housed in the catheter body 10, and FIG. 3(b) shows how the probe 20 protrudes from the catheter body.

As shown in FIG. 2, the catheter body 10 is constructed by combining a tube portion 10a and an insertion end 10b. As shown in FIG. 3, the catheter body 10 has a space near the tip 11, that is, between the tip 11 and the balloon 12 (see FIG. 1), for the urine 31 retained in the bladder 30 to flow. A pair of lateral holes (side holes) 13 are formed. The pair of lateral holes (side holes) 13 are positioned so as to face each other, and are formed to penetrate the wall portion 15 of the catheter main body 10 in a direction perpendicular to the axial direction Z, respectively. The pair of lateral holes (side holes) 13 are formed to have an elongated hole shape expanding in the axial direction Z. As shown in FIG. In addition, it is desirable that two lateral holes (side holes) 13 are formed, but this is not the only option.

A longitudinal hole (tip hole) 14 is formed in the distal end 11 of the catheter body 10 . This vertical hole (tip hole) 14 has a substantially perfect circular shape and is formed so as to pass through the tip 11 in the axial direction Z. As shown in FIG. That is, the longitudinal hole (tip hole) 14 penetrates the distal end 11 of the catheter body 10 in a direction perpendicular to the direction in which the pair of horizontal holes (side holes) 13 penetrate the catheter body 10 . This longitudinal hole (prepared hole) may be a tip portion having an obtuse angle by polishing the tip portion of the catheter body, or only the tip portion may be formed by molding and adhered to the catheter body. .

The inner circumference of the vertical hole (tip hole) 14 is formed to be the same as or shorter than the inner circumference of the flow path 16 passing through the inside of the catheter body 10 . That is, the opening area of the vertical hole (preliminary hole) 14 is the same as or smaller than the opening area of the channel 16 . In addition, the inner circumference of the vertical hole (tip hole) 14 is formed longer than the outer circumference of the probe 20 . Thereby, the probe 20 is slidable so as to pass through the vertical hole (tip hole) 14 . At this time, the catheter body 10 may have a vertical hole (tip hole) 14 having a substantially perfect circular shape and an inner circumference of the vertical hole (tip hole) 14 having substantially the same length as the outer circumference of the probe. Movement of the probe 20 in a direction perpendicular to the center direction Z can be prevented.

The insertion end 10b of the catheter body 10 has an inclined portion 18 having a conical inner peripheral surface. The inclined portion 18 is formed to form an acute angle with the axial direction Z compared to the outer peripheral surface of the insertion end 10b. As a result, when the probe 20 is pushed toward the distal end 11 , the probe 20 is guided by the inclined portion 18 and can easily pass through the vertical hole 14 .

Since a gap is formed between the channel 16 and the probe 20 in the catheter body 10, the urine 31 can flow through this gap. It should be noted that the flow path 16 and the probe 20 may be formed in separate channels within the catheter body 10 .

A procedure for measuring the oxygen partial pressure of urine 31 in bladder 30 using urethral balloon catheter 100 will be described below.

When measuring the oxygen partial pressure of the urine 31 in the bladder 30 using the urethral balloon catheter 100, first, the operator takes out the urethral balloon catheter 100 from a bag-like package (not shown). At this time, the urethral balloon catheter 100 is housed in a package with the probe 20 already incorporated in the catheter body 10 so that the probe 20 does not protrude from the distal end 11 of the catheter body 10 .

After removing the urethral balloon catheter 100 from the package, the operator inserts the distal end 11 of the urethral balloon catheter 100 through the urethra into the bladder 30 . At this time, the probe 20 is retracted within the catheter body 10 so that the probe 20 does not protrude outward from the distal end 11 of the urethral balloon catheter 100 through the longitudinal hole (tip hole) 14 .

After inserting the distal end 11 of the urethral balloon catheter 100 into the bladder 30 , the operator connects a syringe to the one-way valve 17 a connected to the branch connector 17 and inflates the balloon 12 . The urethral balloon catheter 100 is thereby fixed within the bladder 30 .

Once the urethral balloon catheter 100 is secured within the bladder 30, the operator pushes the root of the probe 20 into the branch connector 17, thereby sliding the probe 20 toward the distal end 11 of the catheter body 10 within the channel 16. It is moved so that the tip of the probe 20 penetrates through the vertical hole (tip hole) 14 .

When the tip of the probe 20 is passed through the longitudinal hole (tip hole) 14 , the probe 20 comes into contact with the urine 31 retained in the bladder 30 and can measure the oxygen partial pressure of the urine 31 . At this time, the urine 31 in the bladder 30 flows into the catheter body 10 through the pair of lateral holes (side holes) 13, flows through the gap between the channel 16 and the probe 20, and flows into the branch connector. It is designed to be stored in a connected urine bag (not shown).

However, as described above, the probe 20 may be installed inside the catheter body instead of penetrating the vertical hole (tip hole) 14, and the urine stored in the bladder 30 may pass through the vertical hole (tip hole) 14. Since it flows into the channel 16 of the catheter body 10 from the hole 14 or the side hole 13, the partial pressure of oxygen in urine can be measured.

A urethral balloon catheter 100 according to this embodiment includes a catheter body 10 and a probe 20 for measuring oxygen partial pressure. A longitudinal hole (tip hole) 14 is formed in the tip 11 . As a result, the operator can position the probe 20 at an appropriate position within the urine 31 inside the bladder 30 simply by sliding the probe 20 after inserting the catheter main body 10 into the bladder 30. Partial pressure can be easily measured.

Further, since the probe 20 protrudes from the longitudinal hole (tip hole) 14 of the catheter body 10 in the axial direction Z, the oxygen partial pressure of the urine 31 in the ureter 32 is measured by inserting the probe 20 into the ureter 32. You can also

Although one embodiment of the present invention has been described above, the above-described embodiment of the present invention is for facilitating understanding of the present invention, and does not limit the present invention. The present invention may be modified and improved without departing from its spirit, and the present invention includes equivalents thereof. For example, in the above embodiment, the urethral balloon catheter 100 inserted into the bladder 30 is described, but the present invention is not limited to this, and can be applied to catheters used in other sites, such as catheters inserted into the upper urinary tract. The present invention may be applied.

In the above embodiment, the user inserts the probe 20 through the vertical hole 14 to adjust the insertion depth of the probe 20, but the present invention is not limited to this. For example, the probe 20 may be housed in the package in advance while passing through the vertical hole 14 so that the user does not need to adjust the insertion depth.

Furthermore, in the above embodiment, the oxygen partial pressure of the urine 31 outside the urethral balloon catheter 100 is measured using the probe 20 passing through the vertical hole 14, but the present invention is not limited to this. For example, if the tip of the probe 20 is held within the catheter body 10 and the oxygen partial pressure in the urine 31 can be measured, the oxygen partial pressure of the urine 31 flowing into the catheter body 10 from the vertical hole 14 or the horizontal hole 13 can be measured. good too.

Furthermore, in the above-described embodiment, the branch connector 17 is integrated with the conduit 17a through which the probe 20 penetrates, the discharge conduit 17b for discharging the urine 31, and the delivery conduit 17c for delivering air or the like. provided, the invention is not so limited. For example, the branch connector is divided into two parts, and behind the part where the delivery conduit 17c is provided, the part where the conduit 17a through which the probe 20 penetrates and the discharge conduit 17b for discharging the urine 31 are provided. may be a branch connector in which

Moreover, in the above-described embodiment, the urethral balloon catheter 100 has the inclined portion 18 having a conical shape, but the present invention is not limited to this. For example, as shown in FIG. 5(a), the inner peripheral surface of the tip 11 is formed into a hemispherical inclined portion 19 with a uniform thickness, and as shown in FIG. 5(b), it has a hemispherical shape. It may be guided by the inclined surface 19 and passed through the vertical hole 14 .

DESCRIPTION OF SYMBOLS 10... Catheter main body 11... Tip 12... Balloon 13... Lateral hole (side hole)
14... Vertical hole (tip hole)
DESCRIPTION OF SYMBOLS 15... Wall part 16... Flow path 17... Branch connector 18... Inclined part 19... Inclined part 20... Probe 30... Bladder 31... Urine 32... Ureter 100... Urethral balloon catheter Z... Axial direction

Claims (4)

a catheter body;
a probe for measuring oxygen partial pressure,
A catheter according to claim 1, wherein said catheter body has a longitudinal hole formed at its distal end through which said probe can pass in the axial direction of said catheter body. 2. A catheter according to claim 1, wherein the inner circumference of the longitudinal bore (tip hole) of the catheter is the same as or shorter than the inner circumference of the channel of the catheter body. 3. The catheter according to claim 1, wherein said catheter body has a lateral hole near said tip. A catheter according to claim 3, wherein the inner circumference of the longitudinal bore of the catheter body is shorter than the inner circumference of the transverse bore.

Images