JP7039121B2 - Antiseptic antibacterial agent for cosmetics - Google Patents

Description

The present invention relates to an antiseptic and antibacterial agent for cosmetics. More specifically, the present invention relates to an antiseptic and antibacterial agent for cosmetics useful for skin cosmetics, external skin preparations, hair cosmetics and the like.

Conventionally, parabens, benzoic acid and its salts, salicylic acid and its salts and the like have been used as antiseptic and bactericidal agents in human body application compositions such as cosmetics, pharmaceuticals, quasi-drugs and foods.
However, the above-mentioned conventional preservatives and bactericides have a drawback that the range of concentration used is easily limited because they are highly irritating to the skin and have low safety. For example, the restricted concentration of paraben or benzoate is 1%. , The restricted concentration of benzoic acid and salicylic acid is 0.2%.
In addition, since the number of people who have an allergic reaction to these preservatives and fungicides has increased in recent years, the safety consciousness has increased, and makeup that does not contain any preservatives or fungicides or has a reduced amount of them. The demand for composition is increasing.
Therefore, various attempts have been made to overcome the drawbacks of conventional antiseptic and bactericidal agents, search for highly safe antibacterial substances, and reduce the amount of antiseptic and bactericidal agents used by increasing the efficacy of the antiseptic and bactericidal agents. .. For example, a technique using 1,2-alkanediol, which is safer for the human body (see Patent Document 1), a technique using a glycerol monoalkyl ether (see Patent Document 2), and a technique using ethyl 4-hydroxyphenylacetate (Patent Document). 3) etc. have been reported.

Japanese Unexamined Patent Publication No. 2010-13359 Special Table 2003-535116 Gazette Japanese Unexamined Patent Publication No. 2008-100923

As described above, conventional antiseptic and antibacterial agents such as 1,2-alkanediol, glycerol monoalkyl ether and 4-hydroxyphenylacetate have some antiseptic and antibacterial effects, but exhibit higher antiseptic and antibacterial effects. The development of antiseptic and antibacterial agents is desired.

The present invention has been made in view of the above situation, and an object of the present invention is to provide a preservative antibacterial agent for cosmetics, which exhibits a higher antiseptic antibacterial effect than conventional antiseptic antibacterial agents.

As a result of various studies on antiseptic and antibacterial agents for cosmetics, the present inventor has found that a structural unit (a) derived from an amino group-containing monomer (A) having a specific structure and a structural unit derived from a hydrophobic monomer (B) have a specific structure. It has been found that a copolymer having (b) and having a weight average molecular weight of 4000 to 200,000 exhibits a higher antiseptic and antibacterial effect than conventional antiseptic and antibacterial agents, and can solve the above-mentioned problems brilliantly. I came up with what I could do and arrived at the present invention.

（式（４）～（６）中、Ｒ^６～Ｒ^８は、同一又は異なって、水素原子又は炭素数１～５のアルキル基を表す。Ｘは、直接結合又は２価の連結基を表す。式（４）及び（５）中、Ｒ^１、Ｒ^２は、同一又は異なって、炭素数１～１２の炭化水素基を表す。式（６）中、Ｒ^３～Ｒ^５は、同一又は異なって、炭素数１～１２の炭化水素基を表す。Ｙ^－は、陰イオンを表す。）で表される構造である（但し、単量体成分からエチレン、及び、下記式；

（式中、Ｒ^１１は、水素原子又はメチル基を表す。Ｒ^１２は、水素原子又は炭素数１～２２のアルキル基又はアルケニル基を表す。ＡＯは、同一又は異なって、オキシエチレン基又はオキシプロピレン基を表す。ｐは、オキシアルキレン基の平均付加モル数を表し、１～５０の数である。）で表される単量体を除く。）共重合体を含む化粧料用防腐抗菌剤である。
以下に本発明を詳述する。
なお、以下において記載する本発明の個々の好ましい形態を２つ以上組み合わせたものもまた、本発明の好ましい形態である。 That is, the present invention has a structural unit (a) derived from the amino group-containing monomer (A) and a structural unit (b) derived from the hydrophobic monomer (B), and has a weight average molecular weight of 4000 to 200,000. And
The amino group-containing monomer (A) has the following formulas (4) to (6);

(In formulas (4) to (6), R ⁶ to R ⁸ represent the same or different alkyl groups having a hydrogen atom or 1 to 5 carbon atoms, and X represents a direct bond or a divalent linking group. In formulas (4) and (5), R ¹ and R ² represent the same or different hydrocarbon groups having 1 to 12 carbon atoms. In formula (6), R ³ to R ⁵ are the same or different. Differently, it represents a hydrocarbon group having 1 to 12 carbon atoms. Y ⁻ represents an anion. (However, from the monomer component to ethylene, and the following formula;

(In the formula, R ¹¹ represents a hydrogen atom or a methyl group. R ¹² represents a hydrogen atom or an alkyl group or an alkenyl group having 1 to 22 carbon atoms. AO represents the same or different oxyethylene group or oxy. It represents a propylene group. P represents the average number of moles of an oxyalkylene group added, and is a number from 1 to 50.) Excluding the monomers represented by. ) An antiseptic and antibacterial agent for cosmetics containing a copolymer.
The present invention will be described in detail below.
It should be noted that a combination of two or more of the individual preferred embodiments of the present invention described below is also a preferred embodiment of the present invention.

The cosmetics in the present invention mean cosmetics, pharmaceuticals, quasi-drugs that are directly applied to the skin of the human body, and the cosmetics include skin cosmetics, external skin preparations, hair cosmetics and the like.
The antiseptic and antibacterial agent for cosmetics in the present invention refers to an agent that is used for cosmetics and has antiseptic and / or antibacterial performance. Antiseptic performance is the performance to prevent the invasion, growth and proliferation of microorganisms to prevent rot and fermentation, and antibacterial performance is sterilization (killing microorganisms) and bacteriostatic (suppressing the growth of microorganisms). ) It has good performance such as sterilization, disinfection, sterilization, sterilization, and antifungal properties, and the target microorganisms are bacteria and fungi.

Examples of the above-mentioned bacteria include Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, Salmonella, Moraxella, and Regionella; and Gram-positive bacteria such as Staphylococcus aureus and Clostridium. Examples of the fungus include yeasts such as Candida, Rhodotorula, and baker's yeast; and molds such as red mold and black mold (Aspergillus niger, Aspergillus niger).

The antiseptic antibacterial agent for cosmetics of the present invention (hereinafter, also simply referred to as the antiseptic antibacterial agent of the present invention) has a co-weight having a structural unit derived from an amino group-containing monomer and a structural unit derived from a hydrophobic monomer. It includes coalescence. The reason why the antiseptic and antibacterial properties are exhibited by including such a copolymer is presumed as follows. When the antiseptic antibacterial agent for cosmetics of the present invention is allowed to act on a microorganism, the amino group derived from the amino group-containing monomer of the copolymer is adsorbed on the surface of the microorganism having a negative charge. Furthermore, the hydrophobic group of the copolymer exhibits affinity with the cell membrane portion and interacts with the cell membrane to disrupt the interaction between lipids and the like constituting the cell membrane and / or bind to the membrane. It is presumed that by inhibiting the function of a protein or the like, the cell is destroyed and / or the physiological activity of the cell is inhibited and the microorganism is killed.
Since the copolymer is a polymer, it is safer than the conventional one made of a small molecule compound, and since it is water-soluble, there are few restrictions on its incorporation into cosmetics.
Further, the antiseptic antibacterial agent for cosmetics of the present invention has an effect of emulsifying the cosmetic and an effect of increasing the viscosity of the cosmetic by being blended with the cosmetic, and also has an effect as an emulsifier and a thickener. Can be demonstrated.

The copolymer contained in the antiseptic antibacterial agent for cosmetics of the present invention has a structural unit (a) derived from the amino group-containing monomer (A). The amino group-containing monomer has an ethylenically unsaturated group and the following formula (1);

(In the formula, R ¹ and R ² are the same or different and represent a hydrogen atom and a hydrocarbon group having 1 to 12 carbon atoms.) The first to third-order amino groups or the first to third amino groups. It is a monomer having a neutralized product of a secondary amino group with an acid or a quaternary ammonium base.
The hydrocarbon group may have a chain structure or a ring structure, but a chain structure is preferable. When the hydrocarbon group has a chain structure, it may be linear or have a branch.
The hydrocarbon group is preferably an alkyl group, an alkenyl group or an aryl group, more preferably an alkyl group or an alkenyl group, and even more preferably an alkyl group.
The number of carbon atoms of the hydrocarbon group is preferably 1 to 10, more preferably 1 to 8, still more preferably 1 to 5, and particularly preferably 1 to 2.
At least one of R ¹ and R ² is preferably a hydrocarbon group having 1 to 12 carbon atoms, and more preferably both R ¹ and R ² are hydrocarbon groups. That is, among the primary to tertiary amino groups, a tertiary amino group is preferable.

The primary to tertiary amino groups include the following formula (2);

(In the formula, R ¹ and R ² represent the same or different hydrocarbon atoms or hydrocarbon groups having 1 to 12 carbon atoms. Y ⁻ represents an anion.) preferable. Specific examples and preferred forms of the hydrocarbon group are as described above.

As the quaternary ammonium base, the following formula (3);

(In the formula, R ³ to R ⁵ represent the same or different hydrocarbon groups having 1 to 12 carbon atoms. Y ⁻ represents an anion.) It is preferable that the structure is represented by. Specific examples and preferred forms of the hydrocarbon group are as described above.
The hydrocarbon group having 1 to 12 carbon atoms is preferably an alkyl group having 1 to 12 carbon atoms and an alkenyl group having 2 to 12 carbon atoms.
The number of carbon atoms of R ³ to R ⁵ is more preferably 1 to 10, still more preferably 1 to 7, and particularly preferably 1 to 5.
As the hydrocarbon group of R ³ to R ⁵ , a methyl group or an ethyl group is most preferable.

Y ⁻ in the above formulas (2) and (3) is not particularly limited, but is, for example, a halide ion such as a chlorine ion, a bromine ion or an iodine ion; an alkyl sulfate ion such as a methyl sulfate ion; an organic acid such as an acetate ion. Ions and the like can be mentioned.
For Y ⁻ in the above formula (2), an ion of an organic acid is preferable.
The Y ⁻ in the above formula (3) is preferably a halide ion or an alkyl sulfate ion.

The amino groups include the acids of the tertiary amino group and the tertiary amino group among the neutralized products of the primary to tertiary amino groups and the acids of the primary to tertiary amino groups and the quaternary ammonium bases. Neutralized or quaternary ammonium bases are preferred. As the neutralized product of the tertiary amino group or the tertiary amino group with an acid, a dimethylamino group, a diethylamino group or a neutralized product of these with an acid such as hydrochloric acid or acetic acid is preferable.

The amino group-containing monomer (A) includes the following formulas (4) to (6);

(In formulas (4) to (6), R ⁶ to R ⁸ represent the same or different alkyl groups having a hydrogen atom or 1 to 5 carbon atoms, and X represents a direct bond or a divalent linking group. In formulas (4) and (5), R ¹ and R ² represent the same or different hydrocarbon groups having 1 to 12 carbon atoms. In formula (6), R ³ to R ⁵ are the same or different. Differently, it represents a hydrocarbon group having 1 to 12 carbon atoms. Y ⁻ represents an anion.) It is preferable that the structure is represented by an anion.

The alkyl group having 1 to ⁵ carbon atoms in R8 is preferably a methyl group. The R ⁸ is preferably a hydrogen atom or a methyl group. From the viewpoint of antibacterial properties and hydrolysis resistance, a methyl group is more preferable as ^R8 .
It is preferable that R ⁶ and R ⁷ are hydrogen atoms.

The divalent linking group in the above formulas (4) and (5) is not particularly limited, but for example, the following formula (7);

(In the formula, m represents an integer from 0 to 12.), The following formula (8);

(In the formula, l represents an integer of 0 to 4) and the following formula (9);

(In the formula, k represents an integer of 1 to 10).

Examples of the divalent linking group in the above formula (6) include structures represented by the above formulas (7) to (9) and alkylene groups having 1 to 12 carbon atoms.
The m in the above formula (7) is preferably 1 to 8, and more preferably 1 to 5.
The k in the above formula (9) is preferably 1 to 8, and more preferably 1 to 5.

Specific examples of the amino group-containing monomer (A) include N, N-dimethylaminoethyl (meth) acrylate, N, N-diethylaminoethyl (meth) acrylate, and N, N-dimethylaminopropyl (meth). N, N-dialkylamino group-containing (meth) acrylates such as acrylates and N, N-diethylaminopropyl (meth) acrylates, monomers having a quaternizing agent added to the above monomers, or acids such as hydrochloric acid and acetic acid thereof. Neutralized products; N, N-dimethylaminoethyl (meth) acrylamide, N, N-diethylaminoethyl (meth) acrylamide, N, N-dimethylaminopropyl (meth) acrylamide, N, N-diethylaminopropyl (meth) acrylamide, etc. N, N-dialkylamino group-containing (meth) acrylamides and monomers obtained by adding a quaternizing agent to the above monomers or neutralized products of these with acids such as hydrochloric acid and acetic acid; monomethylaminoethyl (meth) acrylate, mono. Monoalkylamino group-containing (meth) acrylates such as ethylaminoethyl (meth) acrylate, monomethylaminopropyl (meth) acrylate, monoethylaminopropyl (meth) acrylate, 2- (tert-butylamino) ethyl (meth) acrylate. Kinds and neutralized products of these with acids such as hydrochloric acid and acetic acid; monomethylaminoethyl (meth) acrylamide, monoethylaminoethyl (meth) acrylamide, monomethylaminopropyl (meth) acrylamide, monoethylaminopropyl (meth) acrylamide, etc. Monoalkylamino group-containing (meth) acrylamides and neutralized products of these with acids such as hydrochloric acid and acetic acid; esters of (meth) acrylic acids such as (meth) acrylic acid-2-aminoethyl and alkanolamines and these. Neutralized product with acid such as hydrochloric acid and acetic acid; N, N-diallylmethylamine and monomer added with a quaternizing agent or neutralized product with acid such as hydrochloric acid and acetic acid; Allylamine and hydrochloric acid thereof. , Neutralized with acid such as acetic acid; 1-allyloxy-3-dibutylamino-2-ol, 1-allyloxy-3-diethanolamino-2-ol, etc. Examples thereof include an addition reaction product of a saturated monomer and an amine compound having 1 to 24 carbon atoms, a monomer having a quaternizing agent added thereto, or a neutralized product thereof with an acid such as hydrochloric acid or acetic acid.

The amine compound having 1 to 24 carbon atoms is not particularly limited as long as it can react with the cyclic ether structure of the unsaturated monomer having an amino group and having a cyclic ether-containing group having 2 to 8 carbon atoms. The carbon number of the amine compound having 1 to 24 carbon atoms is preferably 1 to 20 and more preferably 1 to 16. Examples of the amine compound having 1 to 24 carbon atoms include primary amines and secondary amines, for example, (di) alkylamines having 1 to 24 carbon atoms, (di) alkanolamines having 1 to 24 carbon atoms, and the like. Examples thereof include alkylalkanolamines having 1 to 24 carbon atoms.
Examples of the (di) alkylamine having 1 to 24 carbon atoms include methylamine, ethylamine, propylamine, butylamine, dimethylamine, diethylamine, dipropylamine, dibutylamine, pentylamine, dipentylamine, hexylamine, dihexylamine and heptylamine. , Diheptylamine, octylamine, dioctylamine, dodecylamine, didodecylamine and the like are preferable.
As the (di) alkanolamine having 1 to 24 carbon atoms, methanolamine, ethanolamine, propanolamine, butanolamine, diethanolamine, diethanolamine, dipropanolamine, dibutanolamine, hexanolamine and the like are preferable.
As the alkylalkanolamine having 1 to 24 carbon atoms, methylethanolamine or the like is preferable.

The amino group-containing monomer (A) preferably has a structure in which R8 ⁱⁿ the formulas (4) to (6) is a methyl group and X is a structure represented by the above formula (7).

As the amino group-containing monomer (A), N, N-dialkylamino group-containing (meth) acrylates, neutralized products of these with acids such as hydrochloric acid and acetic acid, and quaternizing agents are added thereto. Monomers, N, N-dialkylamino group-containing (meth) acrylamides and neutralized products of these with acids such as hydrochloric acid and acetic acid, and monomers with a quaternizing agent added to them, especially N, N-dimethylamino. Ethyl (meth) acrylate, N, N-diethylaminoethyl (meth) acrylate, N, N-dimethylaminopropyl (meth) acrylamide, neutralized products of these with acids such as hydrochloric acid and acetic acid, and quaternizing agents are added thereto. The neutralized monomer is more preferable.
The quaternizing agent is not particularly limited, but is an alkyl halide such as methyl chloride, ethyl chloride, methyl bromide, methyl iodide; dimethyl sulfate, diethyl sulfate, di-n-propyl sulfate and the like. Examples thereof include general alkylating agents such as alkyl sulfate.
The amino group-containing monomer may be a tertiary amine or a quaternary ammonium cation, but the tertiary amine exhibits higher antibacterial activity against Gram-negative bacteria and the quaternary ammonium cation against Gram-positive bacteria. become.

The copolymer of the present invention has a structural unit (b) derived from the hydrophobic monomer (B), and the hydrophobic monomer (B) is a homopolymer obtained by homopolymerization. The solubility parameter of (homopolymer) is 15 or less. Even if the solubility parameter is 15 or less, those having an amino group are included in the amino group-containing monomer (A).
Here, the solubility parameter is a value calculated by the method described on pages 147 to 154 of "POLYMER ENGINEERING AND SCIENCE" (1974, Vol. 14, No. 2).
The method is outlined below. The solubility parameter (δ) (cal / cm ³ ) ^1/2 of the homopolymer is as follows, based on the evaporation energy (Δei) and molar volume (Δvi) of the constituent units forming the polymer. It is calculated by the calculation method of.
δ = (△ ei / △ vi) ^1/2 (cal / cm ³ ) ^1/2

If the solubility parameter for the homopolymer obtained by polymerizing the hydrophobic monomer alone is 15 or less, the hydrophobicity in the copolymer of the present invention is sufficient, and the hydrophobicity of the microorganism is sufficient. By improving the affinity for the cell membrane and increasing the interaction with the cell membrane, the physiological activity of the cell membrane is damaged, so that the antibacterial performance is superior to that of the conventional polymer-type antibacterial agent. The solubility parameter is preferably 14 or less, more preferably 13 or less, and further preferably 12 or less. The solubility parameter is usually 5 or more.

The hydrophobic monomer (B) is not particularly limited as long as the solubility parameter in the homopolymer is 15 or less, but it is an ester of (meth) acrylic acid and an alcohol which may have a substituent. ((Meta) acrylates that may have substituents); unsaturated monocarboxylic acids such as (meth) acrylic acid, crotonic acid, α-allyloxyacrylic acid and salts thereof; aromatic vinyl such as styrene System monomers; Olefin-based monomers such as propylene; Esters of unsaturated alcohols such as vinyl acetate and carboxylic acids; Vinyl halides such as vinyl chloride; Alkyl vinyl ethers such as methyl vinyl ethers and ethyl vinyl ethers; 1-allyloxy Addition reaction product of unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms such as -3-butoxypropane-2-ol and alcohol having 1 to 20 carbon atoms; ethylene oxide adduct of allyl alcohol, meta. Ester adducts of unsaturated alcohols having 2 to 20 carbon atoms such as ethylene oxide adducts of lyl alcohols and ethylene oxide adducts of isoprenol and their terminal hydrophobic modified products; cyclic vinyl monomers such as N-vinylpyrrolidone are mentioned. Be done.
Among the hydrophobic monomers having a solubility parameter of 15 or less, those having an alkyl group having 2 or more carbon atoms are preferable. When the hydrophobic monomer has an alkyl group having 2 or more carbon atoms, the affinity with the cell membrane of the microorganism is increased, and the antibacterial property is further improved.

Examples of the unsaturated monocarboxylic acid salt include metal salts. Examples of the metal of the metal salt include alkali metals such as lithium, sodium and potassium.

Examples of the substituent in the (meth) acrylate include a hydroxyl group; an alkoxy group having 1 to 18 carbon atoms such as a methoxy group and an ethoxy group; an oxo group-containing group such as an oxyalkylene group, a sulfonic acid group and a phosphoric acid group; a fluoro group and the like. Harogeno group; epoxy group such as glycidyl group; carbonyl group such as aldehyde group and the like.

The (meth) acrylate which may have the above-mentioned substituent is not particularly limited, but the following general formula (10);

(In the formula, R ⁹ represents a hydrogen atom or a methyl group. R ¹⁰ represents a hydrocarbon group which may have a substituent.) It is preferably a compound represented by.
The hydrocarbon group which may have a substituent means a group in which one or two or more hydrogen atoms of the hydrocarbon group are substituted with a group other than the hydrocarbon group. When the hydrocarbon group has a substituent and the substituent has a (poly) oxyalkylene group, the number of carbon atoms of the hydrocarbon group is preferably 3 to 200. At least when the substituent does not have a (poly) oxyalkylene group, the hydrocarbon group which may have a substituent preferably has 1 to 30 carbon atoms. The number of carbon atoms of the hydrocarbon group which may have the above-mentioned substituent shall include the number of carbons contained in the substituent when the above-mentioned substituent is included in the above-mentioned carbon number.

The hydrocarbon group is not particularly limited, and examples thereof include a chain hydrocarbon group such as an alkyl group, an alkenyl group, and an alkynyl group, and a cyclic hydrocarbon group such as an aromatic hydrocarbon group, a cycloalkyl group, and a cycloalkenyl group. ..
Examples of the alkyl group include a methyl group, an ethyl group, a propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a pentyl group, an isopentyl group, a neopentyl group and a hexyl group. Heptyl group, octyl group, 2-ethylhexyl group, isooctyl group, nonyl group, 2,3,5-trimethylhexyl group, decyl group, undecyl group, 4-ethyl-5-methyloctyl group, dodecyl group, tridecyl group, tetradecyl Examples thereof include a linear or branched alkyl group such as a group, a pentadecyl group, a hexadecyl group, a heptadecyl group and an octadecyl group.
Examples of the alkenyl group include a vinyl group, an allyl group, a 1-butenyl group, a 2-butenyl group, a pentenyl group, a hexenyl group, a heptenyl group, an octenyl group, a nonenyl group, a decenyl group, a dodecenyl group, an octadecenyl group and an icosenyl group. And so on.
Examples of the alkynyl group include an ethynyl group, a 1-propynyl group, a 2-propynyl group, a butynyl group, a pentynyl group, a hexynyl group, a heptynyl group, an octynyl group, a nonynyl group, a decynyl group, a dodecynyl group, an octadecynyl group and an icocinyl group. And so on.

Examples of the aromatic hydrocarbon group include a phenyl group, a benzyl group, a tolyl group, an o-kisilyl group and the like.
Examples of the cycloalkyl group include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group and the like.
Examples of the cycloalkenyl group include a cyclopropenyl group, a cyclobutenyl group, a cyclopentenyl group, a cyclohexenyl group and the like.

Examples of the alkyl (meth) acrylate having no substituent as described above include methyl (meth) acrylate, ethyl (meth) acrylate, n-propyl (meth) acrylate, isopropyl (meth) acrylate, and n-butyl (meth) acrylate. ) Acrylate, Isobutyl (meth) acrylate, tert-butyl (meth) acrylate, sec-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, n-octyl (meth) acrylate, tridecyl (meth) acrylate, cyclohexyl (meth) ) Cycloalkyl (meth) acrylates such as acrylates, n-lauryl (meth) acrylates, dodecyl (meth) acrylates, stearyl (meth) acrylates, isobornyl methacrylates and the like.

Examples of the hydroxyl group-containing (meth) acrylate include 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, 3-hydroxypropyl (meth) acrylate, 2-hydroxybutyl (meth) acrylate, and 4-hydroxy. Examples thereof include hydroxyl group-containing (meth) acrylates having 1 to 18 carbon atoms in ester groups such as butyl (meth) acrylates.

Examples of the alkoxy group-containing (meth) acrylate include methoxyethyl (meth) acrylate, methoxypropyl (meth) acrylate, methoxybutyl (meth) acrylate, ethoxybutyl (meth) acrylate, and trimethylolpropane tripropoxy (meth) acrylate. Can be mentioned.

Examples of the oxo group-containing (meth) acrylate include sulfopropyl (meth) acrylate; (meth) acryloyloxyethyl phosphate and the like.

Examples of the fluorogroup-containing (meth) acrylate include a fluorogroup having 2 to 6 carbon atoms in an ester group such as trifluoroethyl (meth) acrylate, tetrafluoropropyl (meth) acrylate, and octafluoropentyl (meth) acrylate. Examples thereof include alkyl (meth) acrylate.

Examples of the epoxy group-containing (meth) acrylate include glycidyl (meth) acrylate and α-methylglycidyl (meth) acrylate.

Examples of the carbonyl group-containing (meth) acrylate include acetoxy (meth) acrylate, diacetone (meth) acrylate, 2-hydroxypropyl (meth) acrylate acetyl acetate, butanediol-1,4-acrylate acetyl acetate, and 2- (aceto). Examples thereof include acetoxy) ethyl (meth) acrylate and (meth) acryloyloxyalkylpropenal.

The hydrophobic monomer (B) preferably contains at least one (meth) acrylic acid ester.
The (meth) acrylic acid ester may be a compound represented by the above formula (10) and having a hydrocarbon group of R10 of the formula ( ¹⁰ ) having 1 to 20 carbon atoms. preferable.
The hydrocarbon group of R10 of the above formula ( ¹⁰ ) has more preferably 1 to 16 carbon atoms, further preferably 1 to 12 carbon atoms, particularly preferably 1 to 8 carbon atoms, and most preferably 2 to 8 carbon atoms. Is.
When the number of carbon atoms of the hydrocarbon group is 1 to 20, the water solubility and viscosity of the polymer can be in a suitable range, and the handling is excellent. When the hydrocarbon group has 1 to 12 carbon atoms, the polymer can be easily produced, and the safety is excellent in addition to the antibacterial property. Further, when the hydrocarbon group has 2 to 8 carbon atoms, not only the polymer can be easily produced, but also the safety is excellent, the affinity with the cell membrane of the microorganism is increased, and the antibacterial property is further improved. It becomes a thing.
The hydrocarbon group is preferably an alkyl group or an alkenyl group, and more preferably an alkyl group.
That is, the (meth) acrylic acid ester is preferably a (meth) acrylic acid alkyl ester (alkyl (meth) acrylate), and the hydrophobic monomer (B) is at least one (meth) acrylic acid alkyl ester. It is preferable to include it.

The alkyl (meth) acrylate is preferably methyl (meth) acrylate, ethyl (meth) acrylate, n-propyl (meth) acrylate, isopropyl (meth) acrylate, n-butyl (meth) acrylate, isobutyl (meth) acrylate, tert-. Butyl (meth) acrylate, sec-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, n-octyl (meth) acrylate, more preferably methyl (meth) acrylate, ethyl (meth) acrylate, n- With propyl (meth) acrylate, isopropyl (meth) acrylate, n-butyl (meth) acrylate, isobutyl (meth) acrylate, tert-butyl (meth) acrylate, sec-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate. be.

The copolymer contained in the antiseptic antibacterial agent of the present invention also has a structural unit derived from a (meth) acrylic acid alkyl ester as a hydrophobic monomer (B) and a solubility parameter of 15 or less, and is carboxyl. It preferably has a structural unit derived from a monomer having at least one functional group selected from the group consisting of a group, a hydroxyl group and an ether group. Copolymers having such structural units are also one of the preferred embodiments of the present invention.
The monomer having at least one functional group selected from the group consisting of a carboxyl group, a hydroxyl group and an ether group has a solubility parameter of 15 or less and has any functional group of a carboxyl group, a hydroxyl group and an ether group. It may have at least one functional group selected from the group consisting of a carboxyl group, a hydroxyl group and an ether group, even if it has a (meth) acrylic acid ester structure. It shall be classified as a monomer.
In the present invention, as the hydrophobic monomer (B), the above (meth) acrylic acid alkyl ester is copolymerized with a monomer having at least one functional group selected from the group consisting of a carboxyl group, a hydroxyl group and an ether group. By doing so, the water solubility of the obtained copolymer is improved, and the influences such as precipitation of the copolymer due to salt and pH and deterioration of antibacterial property can be more sufficiently mitigated. Therefore, in a wide pH range. A copolymer can be used, and it can be suitably used for cosmetic applications in which many are weakly acidic.
Examples of the monomer having at least one functional group selected from the group consisting of a carboxyl group, a hydroxyl group and an ether group include the above-mentioned unsaturated monocarboxylic acids; hydroxyl group-containing (meth) acrylates; alkyl vinyl ethers; 2 to 2 carbon atoms. Examples thereof include an alkylene oxide adduct of 20 unsaturated alcohols; an addition reaction product of an unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms and an alcohol having 1 to 20 carbon atoms.

Examples of the monomer having at least one functional group selected from the group consisting of a carboxyl group, a hydroxyl group and an ether group include unsaturated monocarboxylic acids; hydroxyl group-containing (meth) acrylates; and alkylenes of unsaturated alcohols having 2 to 20 carbon atoms. Oxide adduct; an addition reaction product of an unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms and an alcohol having 1 to 20 carbon atoms is preferable.
As the unsaturated monocarboxylic acids, (meth) acrylic acid and salts thereof are preferable.
As the hydroxyl group-containing (meth) acrylate, 2-hydroxyethyl (meth) acrylate is preferable.

The unsaturated alcohol having 2 to 20 carbon atoms preferably has 2 to 18 carbon atoms, and examples of the unsaturated alcohol having 2 to 20 carbon atoms include vinyl alcohol, allyl alcohol, and isoprenil alcohol (isoprenol). Can be mentioned.
The carbon number of the alkylene oxide in the unsaturated alcohol alkylene oxide adduct having 2 to 20 carbon atoms is preferably 2 to 20, more preferably 2 to 8, and further preferably 2 to 6. , Particularly preferably 2 to 4, and most preferably 2 to 3. Examples of the alkylene oxide include ethylene oxide, propylene oxide, butylene oxide, isobutylene oxide, 1-butene oxide, 2-butene oxide, and styrene oxide. Ethylene oxide, propylene oxide and butylene oxide are more preferable, and ethylene oxide and propylene oxide are more preferable.
The average number of moles of the alkylene oxide added is preferably 1 to 100. It is more preferably 1 to 80, still more preferably 1 to 70, and particularly preferably 1 to 50.
As the alkylene oxide adduct of the unsaturated alcohol having 2 to 20 carbon atoms, an ethylene oxide adduct of isoprenol is preferable.

Examples of the alcohol having 1 to 20 carbon atoms include alkyl alcohols such as methanol, ethanol, propanol, butanol, pentanol and hexanol. It is preferably an alkyl alcohol having 2 to 16 carbon atoms such as ethanol, propanol and butanol.
As the addition reaction product of the unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms and the alcohol having 1 to 20 carbon atoms, 1-allyloxy-3-butoxypropane-2-ol is preferable.

The copolymer of the present invention may have a structural unit derived from other monomers other than the amino group-containing monomer (A) and the hydrophobic monomer (B). The other monomer is not particularly limited as long as it does not have an amino group and can be copolymerized with the amino group-containing monomer and the hydrophobic monomer. The solubility parameter of the other monomer in the homopolymer may be 15 or less or more than 15. Regardless of whether the solubility parameter of the other monomer is 15 or less or more than 15, the hydrophobicity as a copolymer is as long as the above hydrophobic monomer is polymerized at a preferable ratio. It will be sufficiently maintained.
Further, from the viewpoint of adjusting the viscosity, a monomer having two or more ethylenically unsaturated groups may be contained regardless of the value of the solubility parameter. Examples of the monomer having two or more ethylenically unsaturated groups include ethylene glycol, propylene glycol, polyoxyethylene glycol, polyoxypropylene glycol, glycerin, polyglycerin, trimethylolpropane, pentaerythritol, saccharose, sorbitol, 1, Esters of 2-substituted or more hydroxyl groups of polyols such as 4-butanediol and (meth) acrylic acid; 2-substituted or more methacrylic acid esters of the above polyols; 2-substituted or more hydroxyl groups of the polyols and allyl alcohols, vinyl alcohols Ethers with unsaturated alcohols such as diallyl phthalate, triallyl phosphate, allyl methacrylate, tetraallyloxyetane, triallyl cyanurate, divinyl adipate, vinyl crotonate, 1,5-hexadiene, divinylbenzene, etc. Can be mentioned. These other monomers may be used alone or in combination of two or more.
From the viewpoint of improving the antibacterial property, the present invention may copolymerize a polymerizable metal salt as another monomer. Examples of the polymerizable metal salt include heavy metal salts of unsaturated carboxylic acids such as zinc acrylate, zinc methacrylate and zinc α-allyloxyacrylate.

In the copolymer of the present invention, the content ratio of the structural unit derived from the hydrophobic monomer (B) in the copolymer is the structural unit (a) 100 derived from the amino group-containing monomer (A) in the copolymer. It is preferably 0.1 to 99.9% by mass with respect to the mass%. It is more preferably 0.5 to 90% by mass, further preferably 1 to 80% by mass, still more preferably 2 to 70% by mass, still more preferably 3 to 64% by mass, and even more preferably 4 It is about 60% by mass, particularly preferably 5 to 50% by mass, still more preferably 5 to 40% by mass, and most preferably 5 to 30% by mass. When the content ratio of the structural unit derived from the hydrophobic monomer (B) in the copolymer of the present invention is within such a range, the antibacterial performance of the above-mentioned copolymer is improved, and in particular, Escherichia coli having an outer membrane and Escherichia coli. It tends to show high antibacterial performance against gram-negative bacteria such as Pseudomonas aeruginosa.

As described above, the copolymer of the present invention is selected as the hydrophobic monomer (B) from at least a group consisting of a structural unit derived from a (meth) acrylic acid alkyl ester and a carboxyl group, a hydroxyl group and an ether group. It may have a structural unit derived from a monomer having one kind of functional group, and may be derived from a monomer having at least one kind of functional group selected from the group consisting of a carboxyl group, a hydroxyl group and an ether group in the above copolymer. The ratio of the structural unit of is preferably 0 to 100% by mass with respect to 100% by mass of the structural unit derived from the (meth) acrylic acid alkyl ester. More preferably, it is 0 to 50% by mass.

The copolymer of the present invention contains 0.01 to 99.9 mass of the structural unit (a) derived from the amino group-containing monomer (A) with respect to 100% by mass of the total amount of the structural units forming the copolymer. It is preferable to have it in a ratio of%. It is more preferably 0.1 to 99% by mass, still more preferably 1 to 98% by mass, still more preferably 10 to 97% by mass, still more preferably 30 to 96% by mass, and even more preferably 36. It is ~ 96% by mass, particularly preferably 50 to 95% by mass, more preferably 60 to 95% by mass, and most preferably 70 to 95% by mass.
The copolymer of the present invention contains 0.01 to 90% by mass of the structural unit (b) derived from the hydrophobic monomer (B) with respect to 100% by mass of the total amount of the structural units forming the copolymer. It is preferable to have it in. It is more preferably 0.05 to 80% by mass, further preferably 0.1 to 70% by mass, still more preferably 0.2 to 64% by mass, and even more preferably 0.5 to 60% by mass. It is even more preferably 1 to 50% by mass, particularly preferably 3 to 50% by mass, even more preferably 4 to 40% by mass, and most preferably 5 to 30% by mass.

When the structural unit derived from the (meth) acrylic acid alkyl ester is used as the structural unit derived from the hydrophobic monomer (B) of the copolymer of the present invention, the total amount of the structural units forming the copolymer is 100% by mass. The ratio of the structural unit derived from the (meth) acrylic acid alkyl ester is preferably 0.01 to 60% by mass. It is more preferably 1 to 50% by mass, still more preferably 3 to 40% by mass.

In the antiseptic antibacterial agent of the present invention, the content ratio of the structural unit (e) derived from the other monomer (E) is 0 to 10% by mass with respect to the total amount of the structural unit forming the copolymer of 100% by mass. Is preferable. It is more preferably 0 to 8% by mass, still more preferably 0 to 5% by mass. Among other monomers, the content ratio of the structural unit derived from the monomer having two or more ethylenically unsaturated groups is 0 to 1% by mass with respect to the total amount of 100% by mass of the structural units forming the copolymer. It is preferably 0 to 0.5% by mass, more preferably 0 to 0.1% by mass.

The copolymer contained in the antiseptic antibacterial agent of the present invention comprises only the structural unit (a) derived from the amino group-containing monomer (A) and the structural unit (b) derived from the hydrophobic monomer (B). Copolymers are also one of the preferred forms. In this case, the total of the ratios of the structural units (a) and (b) is 100% by mass, and the ratio of the structural units (a) or (b) is from 100% by mass to the above-mentioned structural unit (b) or ( It is the value obtained by subtracting the ratio of a).

The weight average molecular weight of the copolymer contained in the antiseptic antibacterial agent for cosmetics of the present invention is 40 to 1 million. When the weight average molecular weight of the copolymer is in such a range, the adsorptivity of the antiseptic antibacterial agent to the material using the antiseptic antibacterial agent is improved. The antibacterial effect on the material is improved.
The weight average molecular weight is preferably 40,000 to 800,000, more preferably 5,000 to 600,000, still more preferably 6,000 to 400,000, still more preferably 7,000 to 200,000, and even more preferably 7,000 to 7,000. It is 100,000, particularly preferably 7,000 to 80,000. The weight average molecular weight of the copolymer can be measured by the method described in Examples.

Examples of the copolymer structure contained in the antiseptic antibacterial agent for cosmetics of the present invention include a random copolymer structure, a graft structure, a block copolymer structure, a gradient copolymer structure, a star-shaped structure, and a dendrimer structure. Any structure may be used.

<Method for producing copolymer>
The production of the copolymer of the present invention is not particularly limited, but it can be produced by polymerizing the monomer component, and specific examples and preferable examples of the monomer component are as described above. Further, the preferable content ratios of the monomers (A), (B) and (E) in the monomer component are the preferable ratios of the structural units (a), (b) and (e) in the above-mentioned copolymer. The same is true.

The copolymer is preferably produced by a method of polymerizing the monomer component in the presence of a polymerization initiator. When polymerizing the monomer component, a polymerization initiator can be appropriately used depending on the polymerization method. As the polymerization initiator, commonly used ones can be used, for example, hydrogen peroxide; persulfate such as sodium persulfate, ammonium persulfate; dimethyl 2,2'-azobis (2-methylpropionate). ), 2,2'-Azobis (isobutyronitrile), 2,2'-azobis (2-methylbutyronitrile), 2,2'-azobis (isobutyric acid) dimethyl, 4,4'-azobis (4) -Cyanovaleric acid), 2,2'-azobis (2-methylpropion amidine) dihydrochloride, 2,2'-azobis [N- (2-carboxyethyl) -2-methylpropion amidine] n hydrate, 2,2'-Azobisisobuty [2- (2-imidazolin-2-yl) propane] dihydrochloride, 2,2'-azobis [2- (2-imidazolin-2-yl) propane] disulfate dihydration Azobisisobuty, 1,1'-azobis (cyclohexane-1-carbonitrile), 2,2'-azobis [N- (2-propenyl) -2-methylpropionamide] and other azo compounds; benzoyl peroxide, peroxidation. Organic peroxides such as lauroyl, peracetic acid, and di-t-butyl peroxide are suitable. Of these polymerization initiators, azo compounds are preferable. The polymerization initiator is not limited to these examples. These polymerization initiators may be used alone or in combination of two or more.

The amount of the polymerization initiator used is not particularly limited as long as it can initiate the polymerization of the monomer component, but is usually 0.01 to 50 parts by mass with respect to 100 parts by mass of all the monomer components. It is preferably 0.05 to 30 parts by mass, more preferably 0.05 to 20 parts by mass.

As a method of using the amino group-containing monomer used in the present invention, it may be used as an acid neutralized product obtained by neutralizing them with an acid or as a quaternary ammonium salt quaternized with a quaternary agent. By quaternizing the amino group-containing monomer and using it, higher antibacterial performance is exhibited against gram-positive bacteria such as Staphylococcus aureus.
The acid used for neutralizing the amino group-containing monomer is not particularly limited, but is not limited to inorganic acids such as hydrochloric acid and sulfuric acid; acetic acid, citric acid, tartaric acid, toluenesulfonic acid, lactic acid, succinic acid and glycolic acid. Organic acids such as.
The quaternizing agent for the amino group-containing monomer is as described above.

When the acid or the quaternizing agent is used, the amount of these used is not particularly limited as long as a part or all of the amino group-containing monomer is neutralized or quaternized, but the polymerization reaction is not limited. The acid or quaternizing agent is preferably 0.1 to 1 mol with respect to 1 mol of the amino group-containing monomer used.

In the above-mentioned copolymerization method, as a method of adding the monomer component, the polymerization initiator, etc. to the reaction vessel, all the monomer components are charged in the reaction vessel, and the polymerization initiator is added into the reaction vessel. Method of performing polymerization: A part of the monomer component is charged in a reaction vessel, and the polymerization initiator and the remaining monomer component are added continuously or stepwise (preferably continuously) into the reaction vessel. Method of performing polymerization by the method; a method of charging a polymerization solvent in a reaction vessel and adding the entire amount of the monomer component and the polymerization initiator; Is preferable, and the polymerization initiator and the remaining monomer component are added into the reaction vessel (preferably continuously) to carry out the copolymerization. Even in such a method, since the molecular weight distribution of the obtained copolymer can be narrowed (sharpened), the copolymerization can be carried out by sequentially dropping the polymerization initiator and the monomer component into the reaction vessel. preferable.

The copolymerization method can be carried out by, for example, solution polymerization, bulk polymerization, suspension polymerization, emulsification polymerization, living polymerization, graft polymerization and the like, and is not particularly limited, but solution polymerization is preferable. The solvent that can be used at this time is preferably water. When only water is used, it is preferable in that the solvent removal step can be omitted.

The above-mentioned copolymerization method can be carried out by either a batch method or a continuous method. In addition, known solvents can be used as the solvent used in the copolymerization as needed, and water; monohydric alcohols such as methyl alcohol, ethyl alcohol, isopropyl alcohol, butanol, and THF (tetratetra); Polyhydric alcohols such as glycerin, (poly) ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol; aromatic or aliphatic hydrocarbons such as benzene, toluene, xylene, cyclohexane, n-heptane; acetic acid Esters such as ethyl; ketones such as acetone and methyl ethyl ketone; amides such as dimethylformamide; ethers such as diethyl ether and dioxane are suitable. These may be used alone or in combination of two or more. Among these, one or more solvents selected from the group consisting of water and lower alcohols having 1 to 4 carbon atoms may be used from the viewpoint of the solubility of the monomer component and the obtained copolymer. preferable. The solvent is relatively inexpensive, and the production method of the present invention is economically excellent. Further, in the above-mentioned copolymerization method, polyhydric alcohol solvent such as propylene glycol or ethylene glycol may be added to water for polymerization. When the polyhydric alcohol solvent is used in combination with water, the solubility of the polymer can be enhanced and soap-free polymerization can be suppressed more sufficiently. As a result, the formation of a polymer having poor water solubility can be more sufficiently suppressed, and the transparency of the solution can be further improved.
When the polyhydric alcohol solvent and water are used in combination, the ratio of the polyhydric alcohol solvent to 100% by mass of water is preferably 0 to 200% by mass.
In the method for producing a copolymer of the present invention, any chain transfer agent, pH adjuster, buffer, or the like can be used, if necessary.

The temperature at the time of polymerization is not particularly limited, but is usually 50 to 120 ° C, preferably 60 to 110 ° C. When the temperature at the time of polymerization is in the above range, the residual monomer component tends to decrease. It is not necessary to keep the temperature at the time of polymerization constant during the progress of the polymerization reaction. For example, the polymerization is started from room temperature and the temperature is raised to a set temperature at an appropriate temperature rise time or rate. After that, the set temperature may be maintained, or the polymerization temperature may be changed (increased or lowered) with time during the progress of the polymerization reaction depending on the dropping method of the monomer component, the initiator and the like. May be good. Further, when polymerizing the monomer component, it is preferable to appropriately stir the monomer component so that the monomer component is polymerized uniformly.

The polymerization time is not particularly limited and may be appropriately set according to the progress of the polymerization reaction, but is usually about 2 to 9 hours.
In the present invention, the "polymerization time" represents the time during which the monomer is heated and stirred before the dropping, the time during which the monomer is added, and the aging time after the dropping of the monomer.

The pressure in the reaction system may be normal pressure (atmospheric pressure), reduced pressure, or pressurized. The atmosphere in the reaction system may be either an air atmosphere or an inert atmosphere.

The solid content concentration in the aqueous solution (that is, the polymerized solid content concentration of the monomer) at the time when the polymerization reaction in the above polymerization reaction system is completed is preferably 20% by mass or more, more preferably 25 to 80% by mass. .. As described above, when the solid content concentration at the end of the polymerization reaction is as high as 20% by mass or more, the polymerization can be carried out at a high concentration and in one step. Therefore, an antiseptic antibacterial agent containing a copolymer can be efficiently obtained, for example, the concentration step which is necessary in some cases in the conventional production method can be omitted. Therefore, the production efficiency can be significantly increased, and as a result, the productivity of the antiseptic and antibacterial agent of the present invention can be significantly improved, and the increase in production cost can be suppressed.

In the method for producing a copolymer of the present invention, an aging step may be provided for the purpose of increasing the polymerization rate of the monomer after the addition of all the raw materials used is completed. The aging time is usually 1 to 240 minutes, preferably 1 to 180 minutes, and more preferably 1 to 120 minutes. If the aging time is less than 1 minute, the monomer component may remain due to insufficient aging, and toxicity and odor caused by the remaining monomer become a problem.

Further, the temperature of the polymer solution preferable in the aging step is in the same range as the above-mentioned polymerization temperature. Therefore, the temperature here may be maintained at a constant temperature (preferably the temperature at the time when the dropping is completed), or the temperature may be changed over time during aging.

The antiseptic antibacterial agent of the present invention may contain other components other than the copolymer of the present invention.
The other components are not particularly limited as long as they do not inhibit the antibacterial performance of the antiseptic antibacterial agent, and examples thereof include additives such as alkali adjusting agents, anionic surfactants, compatibilizers and stabilizers. ..
Further, the antiseptic antibacterial agent of the present invention may further contain a metal salt, a metal oxide, a metal hydroxide and the like from the viewpoint of improving the antibacterial property. As the metal in the metal salt, metal oxide, or metal hydroxide, heavy metals such as copper, zinc, and silver are preferable.
The content of the other components is not particularly limited as long as it does not inhibit the antibacterial performance of the antiseptic antibacterial agent, but is preferably 0 to 20% by mass with respect to 100% by mass of the copolymer.

The antiseptic and antibacterial agent of the present invention is preferably used for cosmetic applications such as skin cosmetics, external skin preparations, and hair (hair) cosmetics.
The skin cosmetics are not particularly limited, but for example, basic cosmetics such as lotion, cream, milky lotion, and beauty liquid; makeup cosmetics such as liquid foundation, base milky lotion, teak color, eye shadow, mascara, and lipstick; Cleaning cosmetics such as cleansing creams, facial cleansing foams, and liquid washing pigments; cosmetics such as sunscreen cosmetics (including non-medicinal products); bath cosmetics such as bathing agents. Examples of the external skin preparation include external medicines such as liniment agents, lotions and ointments.
The hair cosmetics are not particularly limited, and examples thereof include shampoos, conditioners, treatments, waxes, sprays, gels, and mists.

The present invention is also a cosmetic containing the antiseptic antibacterial agent for cosmetics of the present invention.
The content ratio of the antiseptic antibacterial agent in the above cosmetics is not particularly limited, but is 5% by mass or less, more preferably 3% by mass or less, still more preferably 1% by mass or less with respect to 100% by mass of the cosmetics.

In addition, the cosmetics and skin external preparations of the present invention include, if necessary, water and additive components generally added to cosmetics and skin external preparations, such as oily bases, moisturizers, feel enhancers, and surface activity. Agents, polymers, thickening / gelling agents, solvents, propellants, antioxidants, reducing agents, oxidizing agents, preservatives / antibacterial agents other than the antiseptic / antibacterial agents of the present invention, chelating agents, pH adjusters, acids, Alkali, powders, inorganic salts, UV absorbers, whitening agents, vitamins and their derivatives, anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging Agents, tightening agents, cooling sensitizers, warming agents, wound healing promoters, stimulants, painkillers, cell activators, plant / animal / microbial extracts, antipruritic agents, keratin exfoliating / dissolving agents, antiperspirants, refreshing agents Agents, astringents, enzymes, nucleic acids, fragrances, pigments, colorants, dyes, pigments, water and the like can be blended.

To exemplify these additive components, examples of the oily base include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, araquil alcohol, behenyl alcohol, jojoba alcohol, kimil alcohol, seraquil alcohol, and bacillus. Higher alcohols such as alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimerdiol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylene Acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eikosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long chain branched fatty acid, dimer acid , Higher fatty acids such as hydrogenated dimer acid and metal soaps such as aluminum salt, calcium salt, magnesium salt, zinc salt and potassium salt, and nitrogen-containing derivatives such as amide; liquid paraffin (mineral oil), heavy Carbides such as liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalane, vaseline, solid paraffin, hydrogenated polydecene; candelilla wax, carnauba wax. , Rice wax, wood wax, mitsuro, montan wax, ozokelite, ceresin, paraffin wax, microcrystallin wax, petrolatum, fisher tropsh wax, polyethylene wax, ethylene / propylene copolymer and other waxes; palm oil, palm oil, palm kernel oil , Saflower oil, olive oil, castor oil, avocado oil, sesame oil, brown oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rose hip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil , Corn oil, rapeseed oil, sunflower oil, wheat germ oil, flaxseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated hojoba Vegetable oils and fats such as oils; animal oils and fats such as beef oil, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; animal products such as whale wax, lanolin, and orange raffy oil. Rows;

Lanolins such as liquid lanolin, reduced lanolin, adsorption purified lanolin, acetate lanolin, acetate liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, acetate lanolin alcohol, acetic acid (cetyl lanolyl) ester, etc. Sphingo phospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogen Phosphorus derivatives such as added egg yolk phospholipids and partially hydrogenated egg yolk phospholipids; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and choleacid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, Cholesteryl stearate, Cholesteryl isostearate, Cholesteryl oleate, Di-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (cholesteryl / octyldodecyl), N-lauroyl-L- Acylsarcosine alkyl esters such as diglutamate (phytosteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl / octyldodecyl), N-lauroylsarcosin isopropyl, cholesteryl 12-hydroxystearate, fatty acid cholesteryl of macadamia nuts, Sterol esters such as macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; phospholipid-cholesterol complex, phospholipid-phytosterol complex Fatty acid complex such as body;

Octyldodecyl myristite, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanate, hexyldecyl octanoate, isotrideyl isononanoate, isononyl isononanoate, octyl isononanoate, isononenate Isodecyl acid, isotridecyl neopentate, isostearyl neopentate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, hexyldecyl dimethyloctanoate, octyldodecyl erucate, cured isostearate. Himasi oil, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, diethyl sebatate, diisopropyl sebatate, dioctyl sebatate, diisopropyl adipate, sebatic acid Monoalcohol carboxylic acid esters such as dibutyloctyl, diisobutyl adipate, dioctyl succinate, triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate;

Triethylhexanoin, glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (capric acid / capric acid) glyceryl, tri (capric acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated Rozine triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl dicosanate behenate, trimethylol propane trioctanoate, trimethylol propane triisostearate, neopentylglycol dioctanoate, neopentyl glycol dicaprate, dioctanoic acid 2-Butyl-2-ethyl-1,3-propanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylol (isostearic acid / sebacic acid) Propane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / logonic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) Polyhydric alcohol fatty acid esters such as polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate);

Diisopropyl dimergilinolate, diisostearyl dimergilinolate, dimersielyl dimergilinolate (isostearyl / phytosteryl), dimerjilinolic acid (phytosteryl / behenyl), dimerjilinol acid (phytosteryl / isostearyl / cetyl / stearyl /) Dimericicic acid or dimer such as behenyl), dimerjilinoleic acid dimergylinoleil, diisostearate dimergelinoleil, dimergylinoleil hydrogenated rosin condensate, dimerjilinol acid-cured castor oil, hydroxyalkyl dimergylinoleil ether, etc. Derivatives of diols; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramic acid monoisopropanolamide). Lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidemethyl MEA) and other fatty acid alkanolamides; dimethicone (dimethylpolysiloxane), highly polymerized dimethicone. (Highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol , Dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, polyether-modified silicone such as cation-modified silicone and dimethiconecopolypoly, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone. , Phosphate-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cationic-modified and polyether-modified silicone, amino-modified and polyether-modified silicone. , Alkyl-modified and polyether-modified silicone, silicones such as polysiloxane / oxyalkylene copolymer; perfluorodecane, pa -Fluorine-based oils such as fluorooctane and perfluoropolyether are preferable.

Examples of the moisturizing agent / feeling improving agent include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, and the like. Polypolymers such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and its polymers; diethylene glycol monoethyl ether Glycol alkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, martitol; glucose, fructose, galactose, mannose , Treose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and maltosylated, hydroxyalkyl. Modifications such as cyclodextrin), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer and other saccharides thereof. Derivatives; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronine sulfate, keratosulfate, dermatane sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; citric acid, tartrate, Organic acids such as lactic acid and salts thereof; urea; salts such as 2-pyrrolidext-5-carboxylic acid and sodium thereof;

Betain (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamate, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, Amino acids such as valine, tryptophan, histidine, taurine and salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptide, keratin-degrading peptide , Hydrolyzed keratin, conchiolin-degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl-hydrolyzed silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein-degrading peptide, acylated peptide Protein peptides and derivatives thereof; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mutin, etc. Hippotaurin, sesame lignan glycoside, glutathione, albumin, lactose; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract, hamamelis water, hechima water, chamomile extract, kanzo extract, confree extract, silk extract, Animal / plant extracts such as Izayoibara extract, Seiyo-no-kogiri-sou extract, Eucalyptus extract, Merilot extract, natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, sphingoglycolipids, ceramides and Ceramides such as sugar ceramide-containing extracts are preferred.

Preferred examples of the surfactant include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymer surfactants. The HLB of the surfactant is not particularly limited and can be used from a low HLB of about 1 to a high HLB of about 20, and it is also preferable to combine a low HLB and a high HLB.
Examples of preferred surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulphates such as sodium lauryl sulphate, triethanolamine lauryl sulphate and ammonium lauryl sulphate; laureth. Polyoxyethylene alkyl sulfates such as sodium sulphate, triethanolamine laures sulphate; sodium cocoylmethyl taurine, potassium cocoyl methyl taurine, sodium lauroyl methyl taurine, sodium myristylmethyl taurine, sodium lauroyl methyl alanine, sodium lauroyl sulcocin, sodium lauroyl sulcocin triethanol. Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine. Acylamino acid salts such as; polyoxyethylene alkyl ether acetates such as sodium laures acetate; succinic acid ester salts such as lauroyl monoethanolamide sodium succinate; fatty acid alkanolamide ether carboxylates; acyl lates; polyoxyethylene fatty amines. Sulfate; fatty acid alkanolamide sulfate; hardened coconut oil fatty acid fatty acid glyceride sulfate such as sodium glycerin sulfate; alkylbenzenepolyoxyethylene sulfate; olefin sulfonate such as α-olefin sulfonate sodium; lauryl lauryl sulfosuccinate disodium, sulfokohaku Alkyl sulfosuccinates such as sodium dioctyl sulphonate; alkyl ether sulfosuccinates such as laures disodium sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate sodium, sodium lauryl polypropylene glycol sulfosuccinate; sodium tetradecylbenzene sulfonate, tetra Alkylbenzene sulfonates such as decylbenzenesulfonic acid triethanolamine; Alkylnaphthalene sulfonates; Alcan sulfonates; Alkyl ether phosphates such as sodium acid, sodium dilaures phosphate, sodium trilaures phosphate, sodium monoolesphosphate; alkyl phosphates such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphate; fatty acid amide ether Phosphate; Phosphatidylglycerol, phosphatidylinositol, phosphatidic acid and other phospholipids; carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfate-modified silicone and other silicone-based anionic surfactants;

Nonionic surfactants include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steares (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), and isosteares (poly). Polyoxyethylene alkyl ethers with various polyoxyethylene additions such as oxyethylene isostearyl ethers), octyldodeces (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkylphenyl ethers; polyoxyethylene hydrogenated castor oil, poly Oxyethylene glycol oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid, etc. Polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholesterolol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / Polyoxyethylene / polyoxypropylene alkyl such as polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether, etc. Ether; Polyoxyethylene / Polyoxypropylene glycol; (Poly) glycerin such as PPG-9 diglyceryl Polyoxypropylene glycol; Glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid Glyceryl, monocotton oil fatty acid glycerin, monoerkaate glycerin, sesquioleate glycerin, α, α'-pyroglutamate oleate glycerin, monostearate glycerin apple acid and other glycerin fatty acid partial esters; polyglyceryl-2 stearate, 3, 4, 5, 6, 8, 10, Distearate Polyglyceryl-6, 10, Tristearate Polyglyceryl-2, Decastarate Polyglyceryl-10, Isostearate Polyglycerate Lil-2, 3, 4, 5, 5, 6, Polyglyceryl-2 diisostearate-2 (diglyceryl diisostearate), 3, 10, Polyglyceryl-2 triisostearate, Tetraisostearic acid. Polyglyceryl-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 6, 8, polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, decaurenic acid Polyglycerin fatty acid ester such as polyglyceryl-10; ethylene glycol monofatty acid ester such as ethylene glycol monostearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid ester; martitol moiety Fatty acid ester;

Multitoll ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, penta-2-ethylhexyl diglycerol sorbitan, tetra Sorbitan fatty acid ester such as -2-ethylhexyl diglycerol sorbitan; sugar derivative partial ester such as sucrose fatty acid ester, methyl glucoside fatty acid ester, undosilenic acid trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; lanolin alcohol; reduction Lanolin; Polyoxyethylene fatty acid mono and diesters such as polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxyethylene / propylene glycol fatty acid ester; poly Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as oxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, poly Polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol Polyoxyethylene sorbitol fatty acid esters such as pentaoleate and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol honeybees; Alkyl glyceryl ethers such as isostearyl glyceryl ether, kimil alcohol, seraquil alcohol, batyl alcohol; polyhydric alcohol alkyl ether; polyoxyethylene alkylamine; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensate; saponin , Sophorolipid and other natural surfactants; polyoxyethylene fat Acid amide; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide) MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA) and other fatty acid alkanolamides;

Alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxides; polyoxyethylene alkyl mercaptans; polyether-modified silicones such as dimethicone copolyol, polysiloxanes and oxyalkylenes. Silicone-based nonionic surfactants such as copolymers, polyglycerin-modified silicones, and sugar-modified silicones; among cationic surfactants, behentrimonium chloride, stealtrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride. Alkyltrimethylammonium chlorides such as; alkyltrimethylammonium bromides such as stearyltrimonium bromides; dialkyldimethylammonium chlorides such as distearyldimonium chlorides and dicocodimonium chlorides; fatty acid amide amines such as stealamidepropyldimethylamine and stearamideethyldiethylamine and The salt; an alkyl ether amine such as stearoxypropyl dimethylamine and its salt or a quaternary salt; ethyl sulfate long chain branched fatty acid (12-31) aminopropyl ethyldimethylammonium, ethyl sulfate lanolin fatty acid amino acid such as aminopropyl ethyldimethylammonium. Amido-type quaternary ammonium salt; polyoxyethylene alkylamine and its salt or quaternary salt; alkylamine salt; fatty acid amide guanidium salt; alkyl etheraminemonium salt; alkyltrialkylene glycol ammonium salt; benzalconium salt; benzethonium Salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmoriphonium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyldimethicone and amodimethicone, cation-modified silicones, cation-modified And silicone-based cationic surfactants such as polyether-modified silicones, amino-modified and polyether-modified silicones; for amphoteric surfactants, N-alkyl-N, N- such as lauryl betaine (lauryldimethylaminoacetic acid betaine). Dimethyl amino acid betaine; fatty acid amide alkyl-N, N-dimethylamino acid betaine such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaine such as sodium cocoamphoacetate and sodium lauroamphoacetate; Alkyl sulfobetaine such as ledimethyltaurin; Sulfate-type betaine such as alkyldimethylaminoethanol sulfate ester; Phospholipid-type betaine such as alkyldimethylaminoethanol phosphate ester; Sphingoline such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin Phospholipids such as lipids, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, and hydroxylated lecithin; silicone-based amphoteric surfactants, etc .; Examples of the activator include polyvinyl alcohol, sodium alginate, starch derivative, tragant gum, acrylic acid / alkyl methacrylic acid copolymer; and various silicone-based surfactants are preferable.

Examples of the polymer / thickener / gelling agent include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, farcerelan, karaya gum, trolley aoi, cara gum, tragant gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potatoes, wheat; xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid and its salts, zansan gum, purulan, gellan gum, chitin , Chitosan, agar, casso extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and salts such as sodium thereof, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethyl Ammium sulfate cellulose, crystalline cellulose, cellulose such as cellulose powder and derivatives thereof; starch-based polymers such as soluble starch, carboxymethyl starch, methyl hydroxypropyl starch, methyl starch, hydroxypropyltrimonium chloride starch, octenyl succinate corn starch aluminum, etc. Alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpidridone / vinyl alcohol copolymer, polyvinylmethyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene. Polyoxypropylene copolymer; (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (Acrylate / stearyl acrylate / ethylamine methacrylate) copolymer and other amphoteric methacrylic acid ester copolymers; (dimethicone / vinyldimethicone) cloth Polymers, (alkyl acrylate / diacetone acrylamide) copolymers, (alkyl acrylate / diacetone acrylamide) copolymers AMP; partially saponified polyvinyl acetates, maleic acid copolymers; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymers; Acrylic resin alkanolamine; polyester, water-dispersible polyester; polya Crylamide; polyacrylic acid ester copolymer such as ethyl polyacrylic acid, carboxyvinyl polymer, salt such as polyacrylic acid and sodium salt thereof, acrylic acid / methacrylic acid ester copolymer;

Acrylic acid / alkyl methacrylic acid copolymer; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaterium-22. , Polyquaternium-39 and other acrylic acid / diallyldimethylammonium chloride / acrylamide copolymers, acrylic acid / cationized methacrylic acid ester copolymers, acrylic acid / cationized methacrylic acid amide copolymers, polyquaterium-47 and the like. Acrylic acid / methyl acrylate / methacrylate propyltrimethylammonium chloride copolymer, choline chloride ester polymer; cationized oligosaccharides, cationized dextran, cationized polysaccharides such as guarhydroxypropyltrimonium chloride; polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and polymer with butyl methacrylate copolymer; acrylic resin emulsion, ethyl polyacrylate emulsion, polyacrylic alkyl ester emulsion, vinyl acetate Polymer emulsions such as resin emulsions, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; Polymers; 12-hydroxystearic acid and salts thereof; dextrin fatty acid esters such as dextrin palmitate and dextrin myristinate; silicic acid anhydride, fumigant silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal. Preferred examples include soap, dialkyl phosphate metal salt, bentonite, hectrite, organically modified clay mineral, sucrose fatty acid ester, and fructo-oligosaccharide fatty acid ester.

Examples of solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol and isopentyldiol. Kind: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate, ethylene glycol dissuccinate; benzyl Preferred examples include propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation freon; LPG, dimethyl ether, carbon dioxide gas and the like.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; asbestosic acid derivatives such as propyl bisulfate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; Sodium bisulfite and other sulfites; Sodium bisulfite and other sulfite hydrogen salts; Sodium bisulfite and other thiosulfates; Metahydrosulfite hydrogen salts; Thiotaurine, hypotaurine; Thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferred. Is mentioned as.
As the reducing agent, thioglycolic acid, cysteine, cysteamine and the like are preferable.
As the oxidizing agent, hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like are preferable.

Examples of the antiseptic / antibacterial agent other than the antiseptic / antibacterial agent of the present invention include hydroxybenzoic acids such as methylparaben, ethylparaben, propylparaben and butylparaben and salts thereof or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-. 1,2-diols such as pentandiol and 1,2-hexanediol; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; triclosan and the like. Halogenized bisphenols, acid amides, quaternary ammonium salts; trichlorocarbanide, zincpyrythion, benzalconium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophen, hinokithiol; phenol, isopropylphenol, Other phenols such as cresol, timole, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion are preferred.
Examples of the chelating agent include edetates (ethylenediamine tetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediamine triacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; ethidronic acid and the like. Phosphonic acid and salts such as sodium salts thereof; Sodium oxalate; Polypolyamino acids such as polyaspartic acid and polyglutamic acid; Sodium polyphosphate, sodium metaphosphate, phosphate; sodium citrate, citric acid, alanine, dihydroxyethylglycine , Gluconic acid, ascorbic acid, succinic acid, tartrate acid are preferred.
pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol. Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Preferred are sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate and ammonium carbonate.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, white mica, gold mica, synthetic mica, red mica, black mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, kei. Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal salt of tungsten acid, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (eg zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, dark blue, carbon black, titanium oxide, fine powder and ultrafine titanium oxide, zinc oxide , Fine particles and ultrafine zinc oxide, alumina, silica, fumigant silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine gold mica, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with silicones such as hydrogen silicone and cyclic hydrogen silicone or other surface treatment agents such as silane or titanium coupling agents to make them hydrophobic. Inorganic powder such as hydrophilized powder; starch, cellulose, nylon powder, polyethylene powder, polymethylmethacrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate -Polymethylmethacrylate laminated powder, polyethylene terephthalate, aluminum, epoxy laminated powder, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders and surface-treated powders of various sizes and shapes, organic and inorganic Composite powders are preferred.
Examples of inorganic salts include sodium chloride-containing salts such as salt, normal salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, ginger, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, etc. Aluminum / potassium sulfate (myoban), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphoric acid Potassiums, calcium phosphates and magnesium phosphates are preferred.

Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl. Anthranic acid-based UV absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl esters, N, N-dimethylparaaminobenzoic acid ethyl esters; Anthranilic acid-based UV absorbers such as homomentyl-N-acetylanthranilate; salicylic acid. And salicylic acid-based ultraviolet absorbers such as sodium salts, amilsalicylate, menthylsalicylate, homomentylsalicylate, octylsalicylate, phenylsalicylate, benzylsalicylate, p-isopropanolphenylsalicylate; octylcinnamate, ethyl-4-isopropylsinnate, methyl. -2,5-Diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy Synnamete, 2-Ethylhexyl p-methoxysinamate (octyl paramethoxysilicate), 2-ethoxyethyl-p-methoxysinamate (sinoxate), cyclohexyl-p-methoxysinamate, ethyl-α-cyano-β-phenyl Ceramic acid-based ultraviolet absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrine), glycerylmono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and its derivatives; 2, 4-Dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-Methoxybenzophenone (oxybenzon-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' -Benzophes such as phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Non-ultraviolet absorber; 3- (4'-methylbenziliden) -d, l-phenyl, 3-benziliden-d, l-phenyl; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy- 5-Methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoilmethane; 5- (3,3-Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octylriazone; urocanic acid such as urocanic acid and ethyl urocanate Derivatives; 2- (2'-hydroxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, dimethoxybenzilidendioxoimidazolidinepropion Preferred examples include hydrantin derivatives such as 2-ethylhexyl acid, phenylbenzimidazole sulfonic acid, terephthalylidenedicanfursulfonic acid, drometrizoletrisiloxane, methyl anthranilate, rutin and its derivatives, orizanol and its derivatives. ..

Examples of the whitening agent include hydroquinone glycosides such as arbutin and α-albutin and their esters; ascorbic acid, ascorbic acid phosphate ester salts such as ascorbic acid, ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, and ascorbic acid. Ascorbic acid fatty acid ester such as tetraisopalmitic acid ester, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid esters, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as; Etc. Plant extracts are preferred.

Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxin hydrochloride, pyridoxin dioctanoate, pyridoxin dipalmitate, and the like. Flavin adenine dinucleotide, cyanocobalamine, folic acid, nicotinic acids such as nicotinic acid amide and benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin E such as β, γ, δ-tocopherol; Other vitamins such as pantothenic acid and biotin; Ascorbic acid phosphate ester salt such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, ascorbic acid tetra Ascorbic acid fatty acid ester such as isopalmitic acid ester, ascorbic stearate, ascorbic palmitate, ascorbic dipalmitate, ascorbic acid alkyl ether such as ethyl ascorbic acid ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid ester. , Ascorbic acid derivatives such as tocopheryl phosphate ascorbic; vitamin derivatives such as tocopherol derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleic acid, tocopherol ferulate, tocopherol phosphate ester, tocotrienol, and other various vitamin derivatives are preferable. Is mentioned as.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokithiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednison, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract. , Plant extracts such as Honoha extract are preferred.

As hair growth agents, blood circulation promoters and stimulants, plant extracts and tinctures such as senburi extract, capsicum tincture, gypsum tincture, gypsum tincture, cantalis tincture; , Borneol, cyclanderate, cinnaridine, trazoline, acetylcholine, verapamil, cepharanthin, γ-orizanol, cepharanthin, vitamin E and derivatives such as tocopherol nicotinate / tocopherol acetate, γ-orizanol, nicotinic acid and nicotinic acid amide / benzyl nicotinate. Derivatives such as ester inositol hexanicotinate and nicotine alcohol, allantin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivative, stigmasterol or stigmasterol and its glycosyl, minoxydil are preferable. Is mentioned as.
As the hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like are preferable.

Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cold sensitizers, warming agents, wound healing promoters, stimulants, painkillers, cell activators, etc. include retinols, retinoic acids, retinoins. Tocopheryl acid; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, hydroxycapric acid, long-chain α-hydroxy fatty acid, long-chain α-hydroxy fatty acid cholesteryl and the like α-or β-Hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; creatin; ceramides, sphingosines; caffeine, xanthin and its derivatives; coenzyme Q10, carotene, lycopene, astaxanthin Antioxidants and active oxygen scavengers such as α-lipoic acid; catechins; flavones such as kelcetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamine, protoanthocyanidin, chlorogenic acid and apple polyphenols. Derivatives such as rutin and glycosides; Derivatives such as hesperidin and glycosides; Lignan glycosides; Perfume substances and derivatives thereof; capsaicin, vanillin and the like and derivatives; insect repellents such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred.

Plant / animal / microbial extracts include iris extract, asitaba extract, asnalo extract, asparagus extract, avocado extract, flaxseed extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract. , Inchkou extract, Uikyo extract, Ukon extract, Woolong tea extract, Uwaurushi extract, Agetsu extract, Echinashi leaf extract, Enmeisou extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otaneninjin extract, Otogirisou extract, Odorikosou extract, Ononis extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cucumber extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi Extract, crow wheat extract, karukade extract, kanzo extract, oil-soluble kanzo extract, kiwi extract, kiou extract, kikurage extract, kina extract, cucumber extract, kiri leaf extract, guanosine, guava extract, kujin extract, kuchinashi extract, kumazasa extract, clara extract, walnut Extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, quail extract, gentiana extract, gennoshoco extract, tea extract, yeast extract, koboku extract, coffee extract, gobo extract, rice extract, rice Fermented extract, fermented rice bran extract, rice germ oil, confree extract, collagen, kokemomo extract, saishin extract, psycho extract, saitai extract, saffron extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract, sansha extract, sansho Extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Jatoba extract, Shakuyaku extract, Shokyu extract, Shobu root extract, Shirakaba extract, White chrysanthemum extract, Sugina extract, Stevia extract, Stevia fermented product, Nishikawayanagi extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract, Seiyouhakka extract, Sage extract, Zeniaoi extract, Senkyu extract, Senburi extract, Souhakuhi extract, Daiou extract, Die Zu extract, Taisou extract, Thyme extract, Dandelion extract, Local clothing extract, Tea extract, Chouji extract, Chigaya extract, Chinpi extract, Tea tree oil, Jincha extract, Togarashi extract, Touki extract, Tokinsenka extract, Tounin extract, Tohi extract, Dokudami extract, Tomato Extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Hass extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietaria extract, Hikiokoshi extract, Bisabolol, Hinoki extract, Bifizus bacterium extract, Biwa extract, Fukitanpopo extract, Fukinotou extract, Bukuryo extract, Butcher bloom extract, Grape extract, Grape seed extract, Propolis, Hechima extract, Benibana extract, Peppermint extract, Bodaiju extract, Button extract, Hop extract, Maikaika extract, Pine extract, Maronie extract , Mizubasho extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Yuri extract, Yokuinin extract, Yomogi extract, Lavender extract, Green tea extract, Eggshell membrane extract, Apple extract, Louis Boss tea extract , Reishi extract, lettuce extract, lemon extract, lotus extract, lotus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, crackle extract and the like are preferable.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like.
Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like.
Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenolsulfonate and the like.
Examples of the refreshing agent include menthol and methyl salicylate.
Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like.
Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like.
Preferred examples of nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and disodium adenosine triphosphate.

As fragrances, acetylsedrene, amilcinnamaldehyde, allylamylglycolate, β-ionone, isoe super, isobutylquinoline, iris oil, iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragor, Eugenol, Oak Moss, Opoponax Resinoid, Orange Oil, Eugenol, Oranthiol, Galaxolid, Carbachlor, L-Carbon, Kamfer, Cannon, Carrot Seed Oil, Clove Oil, Methyl Caynate, Geraniol, Geranylnitrile , Isobornyl acetate, Geranyl acetate, Dimethylbenzylcarbyl acetate, Styralyl acetate, Sedrill acetate, Telepinel acetate, pt-butylcyclohexyl acetate, Vetiberyl acetate, benzyl acetate, Linaryl acetate, Isopentyl salicylate, benzyl salicylate, Sandalwood oil, Santa Roll, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citroneral, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, Stilax resinoid, cedarwood oil, sedren, sedrol, celery seed oil, thyme oil, damascon, damasenon, timol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinen, triplar, nerol, nonanar, 2,6-nonadienol, nonalactone , Pacholi alcohol, vanilla absolute, vanillin, basil oil, pachori oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil , Vetiberol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, millresinoid, muskketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthon, eucalyptus oil, β-yonon, Synthetic fragrances such as lime oil, lavender oil, D-lymonen, linalol, lylar, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils and natural Fragrances and various blended fragrances are preferred.

Dyes / colorants / dyes / pigments include brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, and blue 204. , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213. , Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1. , Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505. , Red 506, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1 , Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow Legal dyes such as No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14;

Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow5, HC Red 3, 4-hydoxypolythrinth (4-hydoxypoly- Pigment-2-it. Nitro dyes such as 2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (Bengala) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and ocher; Inorganic black pigments such as black iron oxide and lower titanium oxide; Inorganic purple pigments such as mango violet and cobalt violet; Inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; Inorganic blue pigments such as ultramarine and dark blue; Titanium oxide coated mica, Titanium oxide coated bismuth oxide, Titanium oxide coated talc, Colored titanium oxide coated mica, Pearl pigments such as bismuth oxychloride and fish scale foil; metal powder pigments such as aluminum powder, copper powder and gold; surface-treated inorganic and metal powder pigments; red 201, red 202, red 204, red 205, red 220 No., Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Organics such as zirconium, barium or aluminum lake such as red 230, red 401, red 505, orange 205, yellow 4, yellow 5, yellow 202, yellow 203, green 3 and blue 1. Pigments; Surface-treated organic pigments; Anthracinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsantine, chalcone, calsamine, quercetin, closin, chlorophyll, curcumin, cochineal, siconin and other naphthoquinones, bixins, flavones, etc. Natural pigments / dyes such as betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenedia Oxidation dye intermediates and couplers such as min, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and salts thereof; autoxidation dyes such as indoline; dihydroxyacetone is preferred. Can be mentioned.

As the water, in addition to normal water and purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytically acidic ionized water, ionized water, and cluster water are preferable.
In addition to these, cosmetic raw material standards, compounding ingredient standards by cosmetic type, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Handbook), non-pharmaceutical raw material standards, Japanese Pharmacy, pharmaceutical additives Ingredients described in standards, official standards for food additives, etc., and the international patent classification IPC is described in Japanese and foreign patent gazettes and patent publication gazettes (including published gazettes and republished gazettes) that belong to the A61K7 classification. It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc. in known combinations, blending ratios, and blending amounts.

The types of cosmetics and external skin preparations of the present invention will be described in more detail. Basic cosmetics include soft cosmetics, astringent cosmetics, cleaning cosmetics, multi-layered cosmetics and the like; emollient lotion, moisture. Lotion, Milky Lotion, Nourishing Lotion, Nourishing Milk, Skin Moisture, Moisture Emulsion, Massage Lotion, Cleansing Lotion, Protect Emulsion, Sun Protect, Sun Protector, UV Care Milk, Sun Screen, Makeup Lotion, Horny Smoother, Elbow Emulsion such as lotion, hand lotion, body lotion; emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, Creams such as suntan cream, hair removal cream, deodorant cream, shaving cream, and keratin softening cream; gels such as moisture gel; essences such as moisturizing essence, whitening essence, and UV protection essence; Kind: Peel-off pack, powder pack, washing pack, oil pack, cleansing mask, etc. Washing pigments; soaps such as cosmetic soaps, transparent soaps, medicated soaps, liquid soaps, shaving soaps, and synthetic cosmetic soaps are preferable.

Preferred makeup cosmetics include white powder / dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment.
Preferred fragrance cosmetics include perfumes, perfumes, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powders, perfume soaps, body lotions and bath oils.
Body cosmetics include body cleaning agents such as body shampoo; deodorant cosmetics such as deodorant lotion, deodorant powder, deodorant spray, and deodorant stick; depigmenting agents, depilatory / depilatory agents; bathing agents; insect repellent sprays, etc. Repellers are preferred.

Shampoos for hair include oil shampoos, cream shampoos, conditioning shampoos, indulgence shampoos, hair color shampoos, rinse-integrated shampoos, etc .; for rinses, treatments, hair packs, color lotions, split hair coats, permanent waves. Agents, straight perm agents, oxidative hair dyes, hair bleach, hair color pretreatment, hair color aftertreatment, perma pretreatment, perma aftertreatment, hair manicure, hair tonic, and hair restorer are preferred.

As the external skin preparation, it can also be used as a dosage form such as an ointment, a patch, a lotion, a liniment, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.
As the dosage form of the cosmetic or skin external preparation of the present invention, emulsification of oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type and the like. Type cosmetics, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste-like cosmetics, stick-like cosmetics, volatile oil-type cosmetics, powder-like cosmetics, jelly-like cosmetics, gel-like cosmetics, paste-like Formulation types such as cosmetics, emulsified polymer type cosmetics, sheet-like cosmetics, mist-like cosmetics, and spray-type cosmetics are preferable.

The antiseptic and antibacterial agent of the present invention has the above-mentioned constitution and can exhibit a higher antiseptic and antibacterial effect than the conventional antiseptic and antibacterial agents. It can be suitably used for skin external preparations such as, hair cosmetics and the like.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. Unless otherwise specified, "part" means "part by weight" and "%" means "mass%".

<Gel Permeation Chromatography (GPC)>
The weight average molecular weight (Mw) of the copolymer was measured by GPC (gel permeation chromatography).
The measurement conditions, equipment, etc. are as follows.
Equipment: Tosoh EcoSEC HLC-8320GPC
Detector: Differential Refractometer (RI) Detector Column: TSKgel α-M, α-2500 manufactured by Tosoh Corporation
Column temperature: 40 ° C
Flow velocity: 0.4 mL / min
Injection amount: 20 μL (sample concentration 0.4 wt% eluent preparation solution)
Calibration curve: Polyethylene glycol GPC software manufactured by GL Sciences: EcoSEC-WS manufactured by Tosoh Corporation
Eluent: 0.5M acetic acid + 0.2M Na nitrate / acetonitrile = 50/50 (v / v)

<Minimum inhibitory concentration (MIC)>
An aqueous solution containing an antiseptic antibacterial agent was sequentially diluted 2-fold in Mueller-Hinton medium to prepare a dilution series of the antiseptic antibacterial agent-containing medium. Then, 50 μL of a medium containing each concentration of antiseptic and antibacterial agent was added to a polystyrene 96-well plate. Next, Escherichia coli (NBRC-15304, NBRC-3972), Staphylococcus aureus, NBRC-15035, NBRC-13276 and Pseudomonas aeruginosa grown on Mueller-Hinton agar medium for 18 hours. , NBRC-13275) were suspended in butterfield buffer to prepare a bacterial solution of about 10 × 10 ⁸ cells / mL. The prepared bacterial solution was diluted to about 10 × 10 ⁶ cells / mL in Mueller-Hinton medium, and 50 μL was added to each dilution series prepared above. After standing at 35 ° C. for 20 hours, the minimum antiseptic antibacterial agent concentration (ppm) in the medium in which the bacteria did not grow was determined as the minimum inhibitory concentration (MIC). The presence or absence of bacterial growth was visually determined by whether the turbidity had increased.
The results are shown in Tables 1 and 2.

<Preservative test 1>
A potato dextrose agar (PDA) medium containing 2000 ppm of the copolymer (preservative antibacterial agent) synthesized in the following synthesis examples 1 to 5 was prepared.
A pre-cultured culture solution diluted with Aspergillus brasiliensis ATCC16404 (Aspergillus niger) to about ¹⁰⁷ cells / mL was prepared as a bacterial suspension, and the suspension was added to 15 ml of PDA medium containing the antiseptic antibacterial agent. .15 ml was mixed and statically cultured at 25 ° C. for 7 days, and the presence or absence of colony formation in the PDA medium after the culture was confirmed.
The results are shown in Table 3.

<Preservative test 2: (Challenge test using O / W cream sample and lotion sample (preservative efficacy test))>
The copolymers (preservatives and antibacterial agents) synthesized in Synthesis Examples 1 to 3 and other components were blended as shown in Table 4 to prepare a cream.
The copolymer (preservative antibacterial agent) synthesized in Synthesis Examples 4 and 5 and other components were blended as shown in Table 6 to prepare a cosmetic water.
The copolymer (preservative antibacterial agent) synthesized in Synthesis Examples 8 and 9 and other components were blended as shown in Table 8 to prepare a cosmetic water.
For the above cream and lotion, a challenge test was conducted by the following method to evaluate the antiseptic power.
For the following bacterial species, a pre-cultured culture solution diluted to about ¹⁰⁸ cells / mL for bacteria and Candida and to about ¹⁰⁷ cells / mL for Aspergillus niger was used as a bacterial suspension. The number of bacteria in the bacterial suspension was confirmed by the colony counting method.
Bacteria: Escherichia coli (NBRC-3972), Staphylococcus aureus (NBRC-13276), Pseudomonas aeruginosa, NBRC-13275)
Yeast: Candida (Candida albicans ATCC10231)
Mold: Aspergillus brasiliensis ATCC16404
20 g of the prepared cream or lotion was put in a dry sterilized glass container, 0.2 ml of the above bacterial suspension was inoculated, and the cells were cultured at 25 ° C. After 2, 7, 14, and 21 days, 1 g of each sample was taken out, diluted with physiological saline and mixed with agar medium, and bacteria and candida were cultured for 48 hours, and Aspergillus niger was cultured for 7 days, and the colony counting method was performed. The number of residual bacteria in the sample was calculated.
The results are shown in Tables 5, 7 and 9.

<Synthesis example 1>
90.0 g of pure water was placed in a glass separable flask equipped with a thermometer, a reflux condenser and a stirrer, and the temperature was raised to 90 ° C. under stirring. Then, under stirring, 2- (dimethylamino) ethyl methacrylate (N, N-dimethylaminoethyl methacrylate) (manufactured by Wako Pure Chemical Industries, Ltd., hereinafter referred to as DAM) 51 in a polymerization reaction system in a constant state at 90 ° C. Monomer solution 1 consisting of 0.3 g, 18.6 g of acetic acid and 8.56 g of ethyl methacrylate (hereinafter referred to as EMA); 2,2'-azobis (2-methylpropionamidine) dihydrochloride (Wako Pure Chemical Industries, Ltd.) ), Initiator aqueous solution consisting of 29.3 g of 2.5% aqueous solution; and monomer solution 2 composed of 25.7 g of DAM and 9.32 g of acetic acid were added dropwise from separate dropping nozzles.
Regarding the dropping start time, the monomer solution 1 and the initiator aqueous solution started dropping at the same time, the monomer solution 1 was dropped for 120 minutes, and the initiator aqueous solution was dropped for 210 minutes. The monomer solution 2 was dropped over 60 minutes after the completion of the dropping of the monomer solution 1. After the completion of all dropping, the reaction solution was kept at 90 ° C. for another 30 minutes and aged to complete the polymerization, and the copolymer 1 was obtained.
The solid content of the obtained copolymer was 36.8%, the pH was 6.41, and the weight average molecular weight was 44900.

<Synthesis example 2>
Polymerization was carried out in the same manner as in Synthesis Example 1 except that EMA was changed to butyl acrylate (hereinafter referred to as BA) to obtain a copolymer 2.
The solid content of the obtained copolymer 2 was 35.7%, the pH was 6.41, and the weight average molecular weight was 45200.

<Synthesis example 3>
50 g of pure water and 22 g of propylene glycol were placed in a glass separable flask equipped with a thermometer, a reflux condenser and a stirrer, and the temperature was raised to 90 ° C. under stirring. Then, under stirring, in a polymerization reaction system in a constant state at 90 ° C., a monomer solution 1 consisting of 63 g of DAM, 24.1 g of acetic acid and 22.5 g of BA; an initiator aqueous solution consisting of 31.9 g of a 5% aqueous solution of V-50; 18% acrylic. A monomer solution 2 composed of 25.6 g of an aqueous acid (hereinafter also referred to as AA) aqueous solution was dropped from separate dropping nozzles. With respect to the dropping start time, the monomer solution 1 was dropped for 180 minutes, and the initiator aqueous solution and the monomer solution 2 were dropped for 210 minutes.
After the completion of all dropping, the reaction solution was kept at 90 ° C. for another 30 minutes for aging to complete the polymerization, and the copolymer 3 was obtained.
The solid content of the obtained copolymer 3 was 34.9%, the pH was 6.15, and the weight average molecular weight was 49500.

<Synthesis example 4>
70 g of 1,3-butanediol was placed in a glass separable flask equipped with a thermometer, a reflux condenser, and a stirrer, and the temperature was raised to 90 ° C. under stirring. Then, under stirring, in a polymerization reaction system at a constant state of 90 ° C., a monomer solution consisting of 73.8 g of DAM and 13.5 g of EMA 1: an initiator aqueous solution consisting of 21.9 g of a 7% aqueous solution of V-50 and 18.3% acrylic acid. The monomer solution 2 composed of 14.7 g of the aqueous solution was dropped from each of the separate dropping nozzles.
Regarding the dropping start time, the monomer solutions 1 and 2 were dropped for 180 minutes, and the initiator aqueous solution and the monomer solution 2 were dropped for 210 minutes.
After the completion of all dropping, the reaction solution was kept at 90 ° C. for another 90 minutes and aged to complete the polymerization. 50 g of pure water was added to obtain a copolymer 4.
The solid content of the obtained copolymer 4 was 35.2%, the pH was 9.0, and the weight average molecular weight was 30500.

<Synthesis Example 5>
60 g of 1,3-butanediol was placed in a glass separable flask equipped with a thermometer, a reflux condenser, and a stirrer, and the temperature was raised to 90 ° C. under stirring. Then, under stirring, in a polymerization reaction system in a constant state at 90 ° C., a monomer solution consisting of 81 g of DEAM 1: an initiator aqueous solution consisting of 28.1 g of a 5% aqueous solution of V-50, and 21.3 g of a 42.4% acrylic acid aqueous solution. The monomer solution 2 was dropped from separate dropping nozzles.
Regarding the dropping start time, the monomer solutions 1 and 2 were dropped for 180 minutes, and the initiator aqueous solution and the monomer solution 2 were dropped for 210 minutes.
After the completion of all dropping, the reaction solution was kept at 90 ° C. for another 90 minutes and aged to complete the polymerization. 50 g of pure water was added to obtain a copolymer 5.
The solid content of the obtained copolymer 5 was 32.9%, the pH was 8.8, and the weight average molecular weight was 22000.

<Synthesis example 6>
24.0 g of pure water and 72 g of propylene glycol (hereinafter, also referred to as PG) were placed in a glass separable flask equipped with a thermometer, a reflux condenser and a stirrer, and the temperature was raised to 90 ° C. under stirring. Then, under stirring, in a polymerization reaction system in a constant state at 90 ° C., a monomer solution 1 consisting of 54 g of DAM and 20.6 g of acetic acid; an initiator aqueous solution consisting of 32.5 g of a 2.5% aqueous solution of V-50; butyl acrylate (BA). The monomer solution 2 consisting of 36 g was dropped from each of the separate dropping nozzles. Regarding the dropping time, the monomer solutions 1 and 2 and the initiator aqueous solution started dropping at the same time, the monomer solutions 1 and 2 were dropped for 180 minutes, and the initiator aqueous solution was dropped for 210 minutes. After the completion of all dropping, the reaction solution was kept at 90 ° C. for another 90 minutes and aged to complete the polymerization, and the copolymer 6 was obtained.
The solid content of the obtained copolymer 6 was 35.2%, and the weight average molecular weight was 22100.

<Synthesis example 7>
Polymerization was carried out in the same manner as in Synthesis Example 6 except that the BA of the monomer solution 2 of Synthesis Example 6 was changed to 2-ethylhexyl acrylate (2EHA) to obtain a copolymer 7. The solid content of the obtained copolymer 7 was 36.4%, and the weight average molecular weight was 70,700.

<Synthesis Example 8>
Instead of propylene glycol, 50 g of pure water and 30 g of 1,3-butanediol (1,3-BG) were charged, and the temperature was raised to 90 ° C. with stirring. Then, under stirring, a monomer solution consisting of 72 g of DAM, 27.52 g of acetic acid, and 18 g of butyl acrylate; an initiator aqueous solution consisting of 29.9 g of a 5% aqueous solution of V-50 was separately added dropwise to the polymerization reaction system at a constant state of 90 ° C. Dropped from the nozzle. The monomer solutions 1 and 2 were added dropwise for 180 minutes, and the initiator aqueous solution was added dropwise for 210 minutes. After the completion of all dropping, the reaction solution was kept at 90 ° C. for another 90 minutes for aging, and 50 g of pure water was added to complete the polymerization to obtain a copolymer 8. The solid content of the obtained copolymer 8 was 31.2%, and the weight average molecular weight was 24900.

<Synthesis example 9>
42.0 g of pure water and 28 g of 1,3-BG were placed in a glass separable flask equipped with a thermometer, a reflux condenser and a stirrer, and the temperature was raised to 90 ° C. under stirring. Then, under stirring, in a polymerization reaction system at a constant state of 90 ° C., a monomer solution consisting of 67.5 g of DAM, 25.8 g of acetic acid, and 18 g of ethyl methacrylate; an initiator aqueous solution consisting of 22.6 g of a 7% aqueous solution of V-50; 27. A monomer solution 2 composed of 16.5 g of a 0.3% AA aqueous solution was dropped from separate dropping nozzles. Regarding the dropping time, the monomer solutions 1 and 2 and the initiator aqueous solution started dropping at the same time, the monomer solutions 1 and 2 were dropped for 120 minutes, and the initiator aqueous solution was dropped for 150 minutes. After the completion of all dropping, the reaction solution was kept at 90 ° C. for another 90 minutes for aging, and 50 g of pure water was added to complete the polymerization to obtain a copolymer 9.
The solid content of the obtained copolymer 9 was 32%, and the weight average molecular weight was 30200.

<Examples 1 to 10 and Comparative Examples 1 and 2: MIC>
The MICs were evaluated for the copolymers 1 to 9 obtained in Synthesis Examples 1 to 9 and methylparaben and phenoxyethanol as comparative examples, and the evaluation results are shown in Tables 1 and 2.

<Examples 11 to 15 and Comparative Example 3: Antiseptic test 1>
Antiseptic test 1 was performed on the copolymers 1 to 5 obtained in Synthesis Examples 1 to 5, and the evaluation results are shown in Table 3. In Comparative Example 3, the same test was conducted without using an antiseptic and antibacterial agent. The evaluation results are shown in Table 3.

<Examples 16 to 18 and Comparative Examples 4 and 5: Antiseptic test 2>
The antiseptic test 2 was performed on the cream prepared as shown in Table 4, and the evaluation results are shown in Table 5.

<Examples 19 and 20 and Comparative Examples 6 and 7: Antiseptic test 2>
The antiseptic test 2 was performed on the lotion prepared as shown in Table 6, and the evaluation results are shown in Table 7.

<Examples 21 and 22 and Comparative Example 8: Antiseptic test 2>
The antiseptic test 2 was performed on the lotion prepared as shown in Table 8, and the evaluation results are shown in Table 9.

<Example 23 and Comparative Example 9: Emulsification performance test>
(Example 23)
5 g of olive oil, 44.4 g of water, and 0.66 g of the copolymer 2 obtained in Synthesis Example 2 were added, and the mixture was emulsified by stirring with a homomixer at a rotation speed of 8000 rpm for 10 minutes. The particle size of the emulsified liquid was measured by a particle size measuring device (concentrated analyzer FPAR-1000; manufactured by Otsuka Electronics Co., Ltd.) and found to be 210 nm.
(Comparative Example 9)
When the emulsification performance test was carried out in the same manner as in Example 16 except that 0.66 g of the copolymer 2 was changed to 0.25 g of the nonionic surfactant NC2305 (manufactured by Nippon Emulsifier), the particle size of the emulsion was found. It was 450 nm.
Further, when the state of the emulsified liquids of Example 23 and Comparative Example 9 left at room temperature for one week was observed, Comparative Example 9 was separated and the emulsified state was broken, whereas Example 23 was emulsified. It was in good condition. From the above, it was clarified that the material of the present invention can be finely dispersed as compared with the existing surfactant, and is also excellent in dispersion stability.

Tables 10 to 17 below show examples of prescription of the cosmetics of the present invention. When the antiseptic test 2 was carried out on the cosmetic composition of the present invention in these formulation examples, the antibacterial activity value (antibacterial activity value = log (number of viable bacteria at the time of inoculation) -log (7 days later) in any of the formulation examples. However, the viable cell count of Aspergillus niger (14 days later)) was 2.0 or more, and the evaluation was judged to be "good".

Prescription example 1-3 Whitening lotion

＊１ 加水分解卵隔膜水溶液（キューピー社製）
＊２ 酵母エキス（山川貿易社製）

* 1 Hydrolyzed egg diaphragm aqueous solution (manufactured by Kewpie)
* 2 Yeast extract (manufactured by Yamakawa Trading Co., Ltd.)

(Production method) The raw material belonging to A was heated to 70 ° C., completely dissolved, and then cooled to room temperature. Then, the raw materials belonging to B were mixed to obtain a whitening lotion.

Prescription example 4-6 milky lotion

(Production method) The raw material of the oil phase portion belonging to A and the raw material of the aqueous phase portion belonging to B were heated to 70 ° C. and completely dissolved, and then the oil phase portion was mixed with the aqueous phase portion and emulsified with a homomixer. The emulsion was cooled to 30 ° C. to obtain an emulsion.

Prescription example 7-9 Moisture cream

(Production method) The raw material of the oil phase portion belonging to A and the raw material of the aqueous phase portion belonging to B were heated to 70 ° C. and completely dissolved, and then the oil phase portion was mixed with the aqueous phase portion and emulsified with a homomixer. The emulsion was cooled to 30 ° C. to obtain a moisture cream.

Prescription example 10-12 Facial cleansing cream

(Manufacturing method) The raw material of the oil phase portion belonging to A and the raw material of the aqueous phase portion belonging to B are heated to 75 ° C. and melted, the aqueous phase portion is mixed with the oil phase portion, and then stirred, and then up to 30 ° C. Cooled to get a face wash cream.

Prescription example 13-15 Sunscreen cream

(Production method) The raw material of the oil phase portion belonging to A and the raw material of the aqueous phase portion belonging to B were heated to 75 ° C. to completely dissolve them, and then the oil phase portion was mixed with the aqueous phase portion and emulsified with a homomixer. The emulsion was cooled to 30 ° C. to give a sunscreen cream.

Prescription example 16-18 Liquid foundation (Shakewell type)

(Manufacturing method) The oil phase portion belonging to A is heated to 60 ° C. and then cooled to room temperature. The raw material of the oil phase portion belonging to A and the raw material of the aqueous phase portion belonging to B were mixed at room temperature and emulsified with a homomixer to obtain a shakewell type liquid foundation.

Prescription example 19-21 shampoo

(Production method) The oil phase portion belonging to A was heated to 80 ° C. and then cooled to room temperature to obtain a shampoo.

Prescription example 22-24 Conditioner

(Production method) The oil phase portions belonging to A and B were heated to 80 ° C., C heated to 80 ° C. was mixed at 80 ° C., and emulsified with a homomixer. The emulsion was cooled to room temperature to obtain a conditioner.

Claims (6)

An antiseptic and antibacterial agent for cosmetics containing a copolymer.
The copolymer has a structural unit (a) derived from the amino group-containing monomer (A) and a structural unit (b) derived from the hydrophobic monomer (B).
The weight average molecular weight is 4000-200,000,
The amino group-containing monomer (A) has the following formulas (4) and / or (5);

(In formulas (4) and (5), R ⁶ to R ⁸ represent the same or different alkyl groups having a hydrogen atom or 1 to 5 carbon atoms, and X represents a direct bond or a divalent linking group. R ¹ and R ² are the same or different and represent a hydrocarbon group having 1 to 12 carbon atoms. Y ⁻ represents an anion.) (However, from the monomer component. Ethylene and the following formula (11);

(In the formula, R ¹¹ represents a hydrogen atom or a methyl group. R ¹² represents a hydrogen atom or an alkyl group or an alkenyl group having 1 to 22 carbon atoms. AO represents the same or different oxyethylene group or oxy. Represents a propylene group. P represents the average number of moles of an oxyalkylene group added, which is a number from 1 to 50), a monomer represented by cetyl polyethoxylated methacrylate, cetearyl polyethoxylated methacrylate, and stearyl. Polyethoxylated acrylate (methacrylate), araxyl polyethoxylated acrylate (methacrylate), behenyl polyethoxylated methacrylate, lauryl polyethoxylated methacrylate, cellotyl polyethoxylated acrylate (methacrylate), montanyl polyethoxylated acrylate (methacrylate), Melicyl polyethoxylated acrylate (methacrylate), laceryl polyethoxylated acrylate (methacrylate), tristyrylphenol polyethoxylated methacrylate, hydrogenated castor oil polyethoxylated methacrylate, canola polyethoxylated acrylate (methacrylate), and cholesterol poly Ethanolylated methacrylate and the following formula (12);

(In the formula, R ¹³ and R ¹⁴ are the same or different, hydrogen atom, methyl group, -C (= O) OH, or -C (= O) OR ¹⁷ , and R ¹⁷ has 1 carbon atom. It is an alkyl group of about 30 and W is -CH ₂ C (= O) O-, -C (= O) O- , -O-, -CH ₂ O-, -NHC (= O) NH-, -C (= O) NH-, ^-Ar- (CR 182 ) _{t -} NHC (= O) O-, -Ar- (CR 182 ⁾ t _{- NHC} (= O) NH-, or -CH ₂ CH ₂ NHC (= O)-, Ar is a divalent aryl group, R ¹⁸ is a hydrogen atom or a methyl group, t is 0 or 1, and q is 0-30. An integer in the range, where r is 0 or 1 and
However, when q is 0, r is 0, and when q is in the range of 1 to 30, r is 1, and (R ¹⁵ O) _s is an oxyalkylene having 2 to 4 carbon atoms. A polyoxyalkylene group that is a homopolyma, random copolyma, or block copolyma of the unit, where R ¹⁵ is C ₂ H ₄ , C ₃ H ₆ , C ₄ H ₈ or a mixture thereof, where s is. It is an integer in the range of 5 to 250, where Z is -R 15 O-, -R ¹⁵ H- ^, -C (= O)-, -C (= O) NH-, -R ¹⁵ NHC (= O ). ) NH- or -C (= O) NHC (= O)-and R ¹⁶ is a linear alkyl group having 8 to 40 carbon atoms, a branched alkyl group having 8 to 40 carbon atoms, and carbon. Substitution selected from the group consisting of an alkyl ring group having 8 to 40 carbon atoms, an alkyl substituted phenyl group having 2 to 40 carbon atoms, an aryl substituted alkyl group having 2 to 40 carbon atoms, and a composite ester having 8 to 80 carbon atoms. Alternatively, it is an unsubstituted alkyl group, wherein the alkyl group of R ¹⁶ optionally comprises one or more substituents selected from the group consisting of hydroxy groups, alkoxy groups and halogens. ) Is excluded. ) An antiseptic and antibacterial agent for cosmetics. The antiseptic antibacterial agent for cosmetics according to claim 1, wherein the hydrophobic monomer (B) has a solubility parameter of 15 or less for the homopolymer. The antiseptic antibacterial agent for cosmetics according to claim 1 or 2, wherein the hydrophobic monomer (B) contains at least one (meth) acrylic acid alkyl ester. In the amino group-containing monomer (A), R8 ⁱⁿ the formulas (4) and / or (5) is a methyl group, and X is the following formula (7);

The antiseptic antibacterial agent for cosmetics according to any one of claims 1 to 3, wherein m represents an integer of 0 to 12 in the formula. The copolymer contains the structural unit (b) derived from the hydrophobic monomer (B) at a ratio of 0.01 to 90% by mass with respect to 100% by mass of the total amount of the structural units forming the copolymer. The antiseptic and antibacterial agent for cosmetics according to any one of claims 1 to 4, which is characterized by having. A cosmetic containing the antiseptic antibacterial agent for cosmetics according to any one of claims 1 to 5.