JP6948131B2 - Lumber for skin sticking and its manufacturing method - Google Patents

Description

The present invention relates to a sticking material for skin sticking and a method for producing the same.

Adhesive plasters, dressing films, taping tapes, and other adhesives to be attached to human skin are desired to have high air permeability.

In order to give the patch material such characteristics, it is necessary to increase the air permeability of the pressure-sensitive adhesive layer together with the support. Here, as the pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer, an emulsion-type pressure-sensitive adhesive using water as a medium is preferably used for environmental protection. As a means for foaming this emulsion-type pressure-sensitive adhesive in order to increase the air permeability of the pressure-sensitive adhesive layer, mechanical foaming (air mixing and stirring) is generally performed (for example, Patent Document 1).

Prior patent documents

Japanese Unexamined Patent Publication No. 2004-84138

However, the patch material described in Patent Document 1 has a problem that it tends to leave a residue when peeled from the skin. Therefore, an object of the present invention is to provide a means for preventing adhesive residue at the time of peeling from the skin while ensuring high air permeability, which is a basic characteristic of a sticking material for skin sticking.

The present invention (1) is a skin sticking material in which an adhesive layer is laminated on a support.
The pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer is an emulsion-type pressure-sensitive adhesive, and a large number of fine vertical through holes penetrating the pressure-sensitive adhesive layer in the thickness direction are formed over the entire surface of the pressure-sensitive adhesive layer. It is a characteristic pasting material.
The present invention (2) is the sticking material of the present invention (1), wherein the average pore diameter of the fine upper and lower through holes is 20 to 400 μm.
The present invention (3) is the sticking material of the invention (1) or (2), wherein the shape of the fine upper and lower through holes is columnar.
The present invention (4) is the patch material of the inventions (1) to (3), wherein the surface density of the fine upper and lower through holes on the surface of the pressure-sensitive adhesive layer in the pressure-sensitive adhesive layer is 2 to 100 pieces / mm ^2. be.
The present invention (5) is the patch material of the inventions (1) to (4), wherein the opening area ratio of the fine upper and lower through holes to the surface area of the pressure-sensitive adhesive layer is 3 to 40%.
The present invention (6) is the sticking material of the inventions (1) to (5), wherein the air permeability of the sticking material is 0.1 to 30 sec / 100 ml.
The present invention (7) is a skin-sticking material in which an adhesive layer is laminated on a support.
The pressure-sensitive adhesive layer has holes formed by decomposing the foaming agent in a state where an emulsion-type pressure-sensitive adhesive liquid containing a foaming agent is applied on a peelable sheet having a fine uneven shape. It is a characteristic pasting material.
According to the present invention (8), the peelable sheet has irregularities on the surface having an arithmetic mean roughness of 0.5 to 3.0 μm and an average length of a roughness curved surface element of 0.05 to 0.20 mm. It is a pasting material of 7).
The present invention (9) is a method for manufacturing a skin sticking material in which an adhesive layer is laminated on a support.
The production method is characterized by comprising a step of applying an emulsion-type pressure-sensitive adhesive liquid containing a foaming agent onto a peelable sheet having a fine concavo-convex shape and decomposing the foaming agent to form pores.
According to the present invention (10), the peelable sheet has irregularities on the surface having an arithmetic mean roughness of 0.5 to 3.0 μm and an average length of a roughness curved surface element of 0.05 to 0.20 mm. 9) The manufacturing method.
The present invention (11) is the production method of the invention (9) or (10), wherein the surface tension of the emulsion-type pressure-sensitive adhesive liquid is 35 mN / m or less.
The present invention (12) is the manufacturing method of the inventions (9) to (11), wherein the skin sticking material is the skin sticking material of the inventions (1) to (6).

According to the present invention, it is possible to provide a means for preventing adhesive residue at the time of peeling from the skin while ensuring high air permeability, which is a basic characteristic of a sticking material for skin sticking. Further, according to the more preferable invention, it is possible to ensure air permeability, sweat discharge property, water resistance, and drug administration to the affected part of the skin surface by applying a drug solution to the surface of the patch. In general, when the cohesive force is increased to prevent adhesive residue, the adhesive force is lowered and the adhesiveness to the skin is remarkably lowered. According to the present invention, this can also be prevented.

FIG. 1 is a perspective view of a sticking material for skin sticking according to the present invention (one example). FIG. 2 is a top view of a sticking material for skin sticking according to the present invention (one example). FIG. 3 is a cross-sectional view of a sticking material for skin sticking according to the present invention (one example). FIG. 4 is a surface state diagram of a peelable sheet having irregularities on its surface by a surface roughness measuring instrument when the adhesive material for skin attachment according to the present invention is manufactured (one example).

Hereinafter, the patch material for skin sticking according to the present invention will be described in the following order.
1. 1. Overall structure and physical properties of the patch material for skin patch 2. Each part 2-1. Adhesive layer 2-1-1. Structure of adhesive layer 2-1-2. Material of adhesive layer 2-1-3. Physical characteristics of the adhesive layer 2-2. Air permeable support 3. Manufacturing method of patch material for skin sticking 3-1. Raw materials / materials used 3-2. Process 4. How to use the sticking material for skin sticking (use)

≪1. Overall structure and physical properties of the adhesive material for skin application ≫
As shown in FIGS. 1 to 3, the skin sticking material 1 according to the present invention constitutes the pressure-sensitive adhesive layer 1A in a skin sticking material in which the pressure-sensitive adhesive layer 1A is laminated on the support 1B. The pressure-sensitive adhesive is an emulsion-type pressure-sensitive adhesive, and a large number of fine vertical through holes 1Aa penetrating the pressure-sensitive adhesive layer 1A in the thickness direction are formed over the entire surface of the pressure-sensitive adhesive layer 1A. It is a sticking material. Although not shown, the skin-adhesive patch 1 according to the present invention has a peeling layer on the surface of the pressure-sensitive adhesive layer 1A opposite to the contact surface with the air-permeable support 1B. (In addition, the peeling layer may be a peelable sheet used in the method for producing a patch material for skin sticking, which will be described below).

The air permeability of the adhesive material for skin application according to the present invention is preferably in the range of 0.1 to 30 sec / 100 ml, more preferably in the range of 0.1 to 20 sec / 100 ml, and is particularly preferable. Is in the range of 0.1 to 10 sec / 100 ml.

<2. Each part>
{2-1. Each part / adhesive layer}
(2-1-1. Structure of each part / adhesive layer / adhesive layer)
Hereinafter, the structure of the pressure-sensitive adhesive layer will be described with reference to FIGS. 1 to 3.

-Thickness First, the thickness of the pressure-sensitive adhesive layer 1A is preferably 5 to 100 μm, more preferably 10 to 80 μm, and particularly preferably 20 to 60 μm.

Fine upper and lower through holes In addition, a large number of fine upper and lower through holes 1Aa penetrating the pressure-sensitive adhesive layer 1A in the thickness direction are formed over the entire surface of the pressure-sensitive adhesive layer 1A. Here, the fine vertical through hole refers to a cylindrical hole formed in the vertical direction with reference to the thickness direction of the pressure-sensitive adhesive layer. Here, the average hole diameter of the fine upper and lower through holes 1Aa is preferably 20 to 400 μm, more preferably 30 to 300 μm, and particularly preferably 40 to 200 μm. Further, the shape of the through hole is preferably cylindrical. As described above, the fine vertical through holes are not particularly limited as long as they are tubular holes (through holes) formed in the vertical direction with reference to the thickness direction of the pressure-sensitive adhesive layer, and are present in, for example, the pressure-sensitive adhesive layer. It is not necessary that all the fine upper and lower through holes pass from the surface of the pressure-sensitive adhesive layer to the air-permeable support. Further, the surface density (foaming density) of the fine upper and lower through holes 1Aa on the surface of the pressure-sensitive adhesive layer is preferably 2 to 100 pieces / mm ² , more preferably 3 to 80 pieces / mm ² , and particularly 4 to 60 pieces / mm. ² is desirable. Further, the opening area ratio (opening ratio) of the fine upper and lower fine pores with respect to the surface area of the pressure-sensitive adhesive layer is preferably 3 to 40%, and more preferably 5 to 30%. Within these ranges, better adhesive air permeability and adhesive properties tend to be achieved. As described above, in order to ensure the basic characteristics (air permeability, etc.) of the adhesive for skin attachment, instead of generating spongy air bubbles by mechanical foaming (air mixing and stirring) in the prior art, the adhesive is used in the present invention. Fine upper and lower through holes are formed over the entire surface of the layer. By adopting such a configuration (in addition to this, the adoption of an emulsion type adhesive and the adoption of an air permeable support), the present inventors can not only realize the basic characteristics as before, but also when peeling from the skin. They found that the unexpected effect of significantly suppressing the adhesive residue could be achieved.

(2-1-2. Materials of each part / adhesive layer / adhesive layer)
As the emulsion type pressure-sensitive adhesive according to the present invention, an acrylic pressure-sensitive adhesive is preferably used. Hereinafter, an emulsion-type acrylic pressure-sensitive adhesive, which is a preferred embodiment, will be described in detail. In the following description, in addition to the description of the emulsion type acrylic pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer, the description of the emulsion-type pressure-sensitive adhesive liquid which is a raw material used for forming the pressure-sensitive adhesive layer is also included.

Suitable emulsion-type acrylic pressure-sensitive adhesives include (meth) acrylic acid alkyl esters having 4 to 12 carbon atoms in alkyl groups, 0.5 to 10% by weight of carboxyl group-containing monomers, and others. Emulsion type acrylic obtained by adding 0.3 to 12 parts by weight of a surfactant to 100 parts by weight of a mixed monomer containing 0 to 40% by weight of a copolymerizable monomer and emulsion polymerization in an aqueous medium. It is an adhesive. Hereinafter, each raw material and polymerization method will be described in detail.

First, the (meth) acrylic acid alkyl ester having an alkyl group having 4 to 12 carbon atoms is an ester of (meth) acrylic acid and an alcohol having 4 to 12 carbon atoms. Here, the alcohol may be linear or branched. Examples of this ester include butyl acrylate, -2-ethylhexyl acrylate, isooctyl acrylate, isononyl acrylate, and decyl acrylate. Further, one type or a combination of two or more types may be used.

Next, the carboxyl group-containing monomer is not particularly limited as long as it is a component having one or more carboxyl groups and a C = C double bond, and is, for example, (meth) acrylic acid, maleic acid, itaconic acid, acrylic acid. Examples thereof include carboxyl group-containing monomers such as 2-carboxyethyl, 2-acyloxyethyl succinic acid, and ω-carboxypolycaprolactone acrylic acid. Further, one type or a combination of two or more types may be used.

Other copolymerizable monomers include, for example, hydroxyl group-containing monomers such as 2-hydroxyethyl acrylate and 2-hydroxypropyl acrylate, amide-based monomers such as (meth) acrylamide and N-methylol acrylamide, styrene, vinyl acetate and the like. Vinyl-based monomers, epoxy group-containing monomers such as glycidyl (meth) acrylate, nitrile-based monomers such as (meth) acrylic nitrile, methyl acrylate, ethyl acrylate, isopropyl acrylate, stearyl acrylate, etc. Examples thereof include polyfunctional monomers such as meth) acrylic acid alkyl ester, triethylene glycol diacrylate, neopentyl glycol diacrylate, and trimethylolpropane triacrylate. This monomer may be used alone or in combination of two or more.

The surfactant as an emulsifier for emulsion polymerization is not particularly limited, and general surfactants can be adopted, specifically, polyoxyethylene alkylaryl ether, polyoxyethylene sorbitan fatty acid ester and the like. Nonionic surfactants, anionic surfactants such as fatty acid soaps, alkyl sulfonates, alkyl succinates, polyoxyethylene alkyl sulfates, alkyltrimethylammonium salts, dialkyldimethylammonium salts, benzalconium chloride Cationic surfactants such as, alkyldimethylaminoacetate betaine, alkyldimethylamine oxide, and amphoteric surfactants such as alkylcarboxymethylhydroxyethyl imidazolium betaine can be mentioned.

The emulsion polymerization is not particularly limited, and known methods, conditions and the like can be applied. For example, a mixed monomer, a polymerization initiator and the like are added to ion-exchanged water in which a surfactant is dissolved, dispersed and emulsified with a high-speed stirrer, and then kept at a constant temperature of 50 to 95 ° C. and copolymerized in an inert atmosphere. A method in which a part of the emulsion is polymerized and the rest is continuously or intermittently dropped to polymerize may be used. The concentration of the surfactant with respect to the entire emulsion-type pressure-sensitive adhesive liquid is preferably in the range of 0.3 to 12% by weight, and the concentration of all the monomers with respect to the entire emulsion-type pressure-sensitive adhesive liquid is preferably in the range of 30 to 70% by weight. do. Examples of the polymerization initiator include persulfates such as ammonium persulfate and potassium persulfate, and water-soluble azo compounds such as azobiscyanovaleric acid. As the polymerization initiator, 0.01 to 5 parts by weight is preferably used with respect to 100 parts by weight of all the monomers.

Additives such as defoamers, thickeners and preservatives, chain transfer agents such as butyl mercaptans and dodecyl mercaptans, tackifier resins and the like, as necessary, to the emulsion-type pressure-sensitive adhesive liquid prepared as described above. May be added. Further, the polyfunctional compound can be post-added to the emulsion type pressure-sensitive adhesive liquid as a cross-linking agent. Further, as the foaming agent added to the emulsion type pressure-sensitive adhesive liquid, a water-soluble foaming agent is used. Specifically, sodium hydrogen carbonate, ammonium hydrogen carbonate, ammonium carbonate and the like are preferably used. The final concentration of the solid content is preferably 30 to 70% by weight. The surface tension of the emulsion-type pressure-sensitive adhesive liquid is preferably 50 mN / m or less, more preferably 35 mN / m or less. As a means for adjusting the surface tension, it is preferable to use a wetting agent. Examples of the wetting agent include sodium polyoxyethylene lauryl ether acetate, polyoxyalkylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, sodium lauryl sulfate, sodium dioctyl sulfosuccinate and the like. Of these, sodium dioctyl sulfosuccinate is preferable. Examples of the cross-linking agent include an oxazoline group-containing water-soluble polymer, an oxazoline group-containing polymer emulsion, an epoxy group-containing resin emulsion, and a carbodiimide group-containing water-soluble polymer. As the thickener, a urethane association type, an acrylic acid polymer type, or the like is preferably used.

{2-2. Each part / support}
Hereinafter, the structure of the support B will be described with reference to FIGS. 1 to 3. The support of the patch material of the present invention is not particularly limited, but it is preferable that the support has good air permeability and / and moisture permeability. Here, the air permeability of the support is preferably in the range of 0.1 to 29 sec / 100 ml. The moisture permeability of the support (measured based on the JIS L 1099 A-1 method (calcium chloride method)) is 3,000 g / m ² · day or more, and 4,000 g / m ² · day or more. preferable. The upper limit of the moisture permeability of the support is not particularly limited, usually, about 10,000g ^/ m 2 · day or less, preferably less than about 8,000g ^/ m 2 · day. For example, a breathable base material such as a non-woven fabric or a felt-like fiber assembly, a perforated plastic film, a porous plastic film having microporous properties, and the like are used. Examples of the material of the non-woven fabric or the felt-like fiber assembly include natural fibers such as cotton, linen, silk, hair and rayon, and synthetic fibers such as polyamide, polyester, polyethylene, polypropropylene, polyacrylic and polyvinyl chloride. Further, as the perforated plastic film, for example, a plastic film (sheet) such as polyethylene, polypropylene, nylon, polyester, or polyvinyl chloride is provided with air permeability by forming small holes by needle, laser, electric discharge machining, or the like. Can be mentioned. At this time, a small hole of 0.1 μm to 10 μm is provided as the opening diameter, but the hole is not limited to this range and is set so as to obtain a predetermined air permeability. As the porous film, for example, an extrusion method is performed by blending a polyolefin resin such as polyethylene or polypropylene or a fluorine resin such as polytetrafluoroethylene with an inorganic filler such as calcium carbonate, particularly one having an average particle size of 30 μm or less. Examples thereof include a film formed by an appropriate method such as, etc., which is stretched by a uniaxial or biaxial method to form a porous film. Further, as the highly moisture permeable film, for example, a polyurethane film can be used as it is. In the case of a polyurethane film, the structure of the main chain may be a polyether type or a polyester type. In this case, it is difficult to administer the drug to the affected part of the skin surface by applying the drug solution to the surface, but a patch material having excellent moisture permeability can be obtained. When a non-woven fabric is used as the support, a weight having a basis weight (basis weight) of ^{about 10 to 200 g / m 2} is preferably used. When a plastic film is used, one having a thickness of about 10 to 200 μm is preferably used. Further, in the present invention, these supports can be used not only as a single layer but also a laminated body in which different air permeable supports are laminated.

<3. Manufacturing method of adhesive material for skin application>
(3-1. Raw materials / materials used)
Among the raw materials and members used in the production of the skin-attaching patch according to the present invention, the emulsion-type pressure-sensitive adhesive liquid and the air-permeable support have been described above, and therefore, the peelable sheet used will be described below. .. The peelable sheet is used in a manner as described in the following process. The peelable sheet is a base material surface-treated with a release agent (for example, silicone resin). Here, the peelable sheet needs to have an uneven surface. The unevenness preferably has an arithmetic mean roughness (Ra) of 0.5 to 3.0 μm, and more preferably 0.8 to 2.0 μm. The average length (RSm) of the roughness curved surface element is 0.05 to 0.20 mm, more preferably 0.07 to 0.18 mm. The base material is preferably made of paper. Of these, high-quality paper and glassine paper are preferable. Here, the wood-free paper refers to Western paper having a chemical pulp content of 100%. In the present invention, the woodfree paper is preferably of a type that can be directly treated with silicone and is surface-treated with clay, a resin emulsion, or polyvinyl alcohol (PVA). Further, the glassine paper is obtained by making a paper using a highly beaten chemical pulp as a raw material and further densifying it with a finishing facility such as a super calendar. Here, the reason why it is considered that fine vertical through holes extending in the thickness direction are formed by using the peelable sheet will be described. First, when the pressure-sensitive adhesive liquid is warmed on the peelable sheet, the foaming agent decomposes and small bubbles are generated. Here, in order to form a large through hole, it is necessary for the small bubbles to coalesce, but when a peelable sheet having moderate unevenness (Ra) is used, the bubbles are coalesced using the concave portion as a scaffold. It is understood to be one (union in the vertical direction). In addition, lateral coalescence (related to hole diameter) is understood to be related to RSm. In the case of medium Ra, it may not be possible to use the concave portion as a scaffolding well, but in this case, if the surface tension is lowered, the adhesive liquid easily infiltrates the concave portion and is easily affected by the unevenness. Therefore, it is understood that the coalescence of bubbles progresses. On the other hand, in the case of a peelable sheet having low Ra without undulations, since there is no scaffolding in the first place, it is presumed that even if the surface tension is lowered, the coalescence of bubbles does not proceed and a through hole cannot be formed.

(3-2. Process)
Hereinafter, an example of the manufacturing process of the patch material for skin sticking according to the present invention will be described. The coater (sheet feeding part, coater head, heat-drying part, and winding part are arranged linearly in this order, and further, the second sheet feeding part is held above the vicinity of the winding part, and the heating-drying part and the winding part are wound. The emulsion-type pressure-sensitive adhesive liquid polymerized on the releasable sheet (with a laminate roll between the parts) is applied to a predetermined thickness by a coater head, and then 80 to 130 ° C. is applied in a heat-drying part. A degree of hot air is blown onto the coated surface (and / or the back surface of the peelable sheet is brought into contact with a Yankee dryer) to dry it, and at the same time, the foaming agent is thermally decomposed to generate gas to form an adhesive layer having through holes. Next, the support sheet unwound from the second sheet feeding portion is attached to the adhesive surface via a laminate roll, and wound up at the winding portion. In this case, the support is previously treated with a release agent such as a silicone resin or a long-chain alkyl group-containing polymer on a surface different from the surface to be bonded with the adhesive, and the releaseable sheet is peeled off again after laminating to adhere. The support on which the agent is transferred and laminated may be wound as it is. The wound raw fabric is hung on a cutting machine to form a roll having an appropriate narrow width, or the unraveled sheet is cut into an appropriate shape to be used as a sticking material.

<4. How to use the sticking material for skin sticking (use)>
The method of using (use) of the sticking material for skin sticking according to the present invention will be described. The skin sticking material according to the present invention is used for sticking to human skin. Examples thereof include adhesive plasters, dressing films, taping tapes, transdermal preparations, and surgical tapes.

Hereinafter, the present invention will be specifically described with reference to Examples. The present invention is not limited to the following examples. Unless otherwise specified, parts and% mean parts by mass (parts by weight) and% by mass (% by weight).

≪Manufacturing example≫
<Example 1>
(Preparation of emulsion type adhesive liquid)
Ion-exchanged water and n-octyl-3-mercaptopropionate, which is a chain transfer agent, are charged in a temperature-adjustable reaction vessel equipped with a thermometer, condenser, nitrogen introduction tube, and stirrer, and stirred with a stirrer under a nitrogen stream. After raising the temperature to 66 ° C., a solution prepared by dissolving 0.25 part of ammonium persulfate as a polymerization initiator in ion-exchanged water was added dropwise, and after 10 minutes, it consisted of 98 parts of 2-ethylhexyl acrylate and 2 parts of acrylic acid. The monomer mixture was continuously added with 3 parts of polyoxyethylene alkyl sulfate and a monomer emulsion obtained by emulsifying and dispersing in ion-exchanged water for 3.5 hours, and the reaction was continued at 66 ° C. for 2 hours to carry out polymerization. After completion, it was cooled. The mixture was filtered through a wire mesh or the like to obtain an acrylic copolymer emulsion pressure-sensitive adhesive liquid (A) having a solid content of 50%. The other emulsified polymers used in this example and the comparative example were produced and used according to the production example.
(Coating process)
Add 5% by weight ammonium hydrogencarbonate, 0.75% by weight cross-linking agent, 1% by weight thickener, and 2% by weight neutralizer to the total amount of the monomer in the pressure-sensitive adhesive liquid (A), and stir. Then, it was used as a coating liquid. After that, a peelable sheet (K8 Shiro E (R0): Lintec Co., Ltd.) whose base material is PVA-treated high-quality paper is fed out from the first feeding portion by a coater, and the coating amount after drying is 38 g / by a comma coater. Apply the coating liquid to a certain thickness so that it becomes m ^2, and dry it in the heat-drying box of the next step. At the same time, decompose the foaming agent, generate gas, provide through holes in the adhesive layer, and dry. When the box is taken out, the polyester non-woven fabric (air permeability 0.2 seconds / 100 ml) unwound from the second feeding part is attached to the adhesive surface via a laminate roll, wound by the winding part, and supported / adhesive. An original winding sample consisting of three layers of agent / removable sheet was used.
(Preparation of pasting material)
The original winding sample was aged in an atmosphere of 40 ° C. for 3 days, cut into a constant size and shape, and subjected to each test.
<Example 2>
The patch material according to Example 2 was produced in the same manner as in Example 1 except that it was changed to a peelable sheet (78EVS (M): Oji F-Tex Co., Ltd.) having different Ra and RSm.
<Example 3>
The patch material according to Example 3 was produced in the same manner except that the base material of the peelable sheet was changed to glassine paper (64 GSM-L: Oji F-Tex Co., Ltd.) in Example 1.
<Example 4>
The patch material according to Example 4 was prepared in the same manner as in Example 3 except that 1% by weight of sodium dioctyl sulfosuccinate was added to the emulsion type pressure-sensitive adhesive liquid (A) and stirred. ..
<Comparative Examples 1 and 2>
Comparative Examples 1 and 2 are the same as in Example 4 except that the base material of the peelable sheet was changed to polylami woodfree paper (80EPS: Oji F-Tex Co., Ltd.) and polyester film (film binar: Fujimori Kogyo Co., Ltd.), respectively. It was produced in the same manner.
<Comparative example 3>
Comparative Example 3 was produced in the same manner as in Comparative Example 2 except that the foaming agent was not added to the emulsion type pressure-sensitive adhesive liquid (A) and the liquid was vigorously stirred with a homomixer to foam and then coated.

≪Evaluation≫
<Test method>
(A. Surface tension of adhesive liquid)
The surface tension was measured at normal temperature and pressure using a Wilhelmy automatic surface tension meter (manufactured by KRUSS).
(B. Detachable sheet)
1. 1. Arithmetic Mean Roughness (Ra: JIS B 0601)
The surface roughness was measured using a surf coder (manufactured by Kosaka Laboratory Co., Ltd.) under the condition of a Z magnification of 10000. The leveling was the least squares method, and the pitch was 10 μm.
2. Roughness Average length of curved surface elements (RSm: JIS B 0601)
From the data measured above, an arbitrary XZ plane was taken out, RSm was measured, 10 planes were measured in the Y direction, and the average value was obtained (see FIG. 4 for the X, Y, and Z axes).
(C. Through hole of adhesive layer)
1. 1. Average pore size An enlarged photograph of the surface of the adhesive was taken with an electron microscope, the diameters of the through holes in this image were read using image analysis software, and the average value of the diameters of all the through holes on the image was obtained. When the hole shape is not a perfect circle, the longest part is used as the diameter.
2. Foaming Density The number of through holes in a 1 mm × 1 mm square randomly selected in the above enlarged photograph was read.
3. 3. Perforation area ratio The above-mentioned enlarged photograph was read using image software, and the through-hole area / patching material area was determined.
(D. Support)
1. 1. Air permeability Same as the method described in E below (E. pasting material)
1. 1. The air permeability was measured using a Garley type densometer (manufactured by Tester Sangyo Co., Ltd.) based on JIS P 8117. A sample was prepared by cutting into a size of 50 mm × 50 mm and removing the peelable sheet, and attached to a tightening plate (base). The area that penetrates the tightening plate has an area of 642 mm ² . After pulling out the inner cylinder and setting it on the stopper, tighten the test piece between the tightening plates. The inner cylinder was gently lowered and the number of seconds (sec) through which 100 ml of air passed was measured. ⊚: 0.1 seconds or more and less than 10 seconds 〇: 10 seconds or more and less than 30 seconds ×: 30 seconds or more 2. A small amount of a drug-permeable drug (ointment and cream) was taken on the fingertips, and the sample piece was applied from the back side of the support while floating in the air, and the state and amount of the drug that permeated and came out were visually confirmed. Judgment was made according to the following criteria. ◯: Sufficiently transparent Δ: Somewhat transparent ×: Almost no transparency 3. Adhesive strength (water resistance)
A sample cut to 15 mm x 75 mm was pasted on the inner part of the forearm of the same person with 4 on the right arm and 3 on the left arm, and lived normally (including shower), and the pasted state was confirmed after 72 hours. Peeled at a speed of 100 mm / min and an angle of 90 °. ◯: There is no peeling or floating of the sample, and the adhesive strength is 0.5 N / 15 mm or more. ×: There is peeling or floating of the sample, and the adhesive strength is less than 0.5 N / 15 mm. At the time of measuring the adhesive strength of the adhesive residue, the presence or absence of adhesive residue after peeling to the skin as an adherend was determined visually and by finger tack.
<Evaluation result>
Table 1 shows the evaluation results.

Claims (9)

In a patch material for skin patch in which an adhesive layer is laminated on a support,
The pressure-sensitive adhesive layer has holes formed by decomposing the foaming agent in a state where an emulsion-type pressure-sensitive adhesive liquid containing a foaming agent is applied on a peelable sheet having a fine uneven shape.
The peelable sheet has irregularities on the surface having an arithmetic average roughness of 0.5 to 3.0 μm and an average length of a roughness curved surface element of 0.05 to 0.20 mm.
A sticking material characterized by that. The patch material according to claim 1, wherein the holes are fine vertical through holes that penetrate the pressure-sensitive adhesive layer in the thickness direction, and a large number of the holes are formed over the entire surface of the pressure-sensitive adhesive layer. The sticking material according to claim 2, wherein the average hole diameter of the fine upper and lower through holes is 20 to 400 μm. The patch material according to claim 2 or 3, wherein the shape of the fine upper and lower through holes is cylindrical. The surface density of the fine upper and lower through holes on the surface of the pressure-sensitive adhesive layer in the pressure-sensitive adhesive layer is 2 to 100 pieces / mm. ² The sticking material according to any one of claims 2 to 4. The patch according to any one of claims 2 to 5, wherein the opening area ratio of the fine upper and lower through holes to the surface area of the pressure-sensitive adhesive layer is 3 to 40%. The patch according to any one of claims 1 to 6, wherein the patch has an air permeability of 0.1 to 30 sec / 100 ml. In a method for manufacturing a patch material for skin application in which an adhesive layer is laminated on a support,
The emulsion type adhesive solution containing a foaming agent was applied on a release sheet having a fine uneven shape, it viewed including the steps of forming a hole by decomposing the foaming agent,
A manufacturing method , wherein the peelable sheet has irregularities on the surface having an arithmetic average roughness of 0.5 to 3.0 μm and an average length of a roughness curved surface element of 0.05 to 0.20 mm. The production method according to claim 8 , wherein the surface tension of the emulsion-type pressure-sensitive adhesive liquid is 35 mN / m or less.

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