JP6207005B2 - Cool sensation composition and external preparation for skin or hair - Google Patents
Cool sensation composition and external preparation for skin or hair Download PDFInfo
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- JP6207005B2 JP6207005B2 JP2013076682A JP2013076682A JP6207005B2 JP 6207005 B2 JP6207005 B2 JP 6207005B2 JP 2013076682 A JP2013076682 A JP 2013076682A JP 2013076682 A JP2013076682 A JP 2013076682A JP 6207005 B2 JP6207005 B2 JP 6207005B2
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- 238000002360 preparation method Methods 0.000 title claims description 38
- 239000000203 mixture Substances 0.000 title claims description 33
- 230000035807 sensation Effects 0.000 title claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 229940041616 menthol Drugs 0.000 claims description 9
- -1 1-menthyl Chemical group 0.000 claims description 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 7
- 239000000194 fatty acid Substances 0.000 claims description 7
- 229930195729 fatty acid Natural products 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 150000005846 sugar alcohols Chemical class 0.000 claims description 7
- 239000004386 Erythritol Substances 0.000 claims description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims description 3
- 235000019414 erythritol Nutrition 0.000 claims description 3
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 3
- 229940009714 erythritol Drugs 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000007764 o/w emulsion Substances 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000832 lactitol Substances 0.000 claims description 2
- 235000010448 lactitol Nutrition 0.000 claims description 2
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 2
- 229960003451 lactitol Drugs 0.000 claims description 2
- 239000000845 maltitol Substances 0.000 claims description 2
- 235000010449 maltitol Nutrition 0.000 claims description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 2
- 229940035436 maltitol Drugs 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 229960001855 mannitol Drugs 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 235000010356 sorbitol Nutrition 0.000 claims description 2
- 239000002826 coolant Substances 0.000 claims 2
- 239000000047 product Substances 0.000 description 11
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 10
- 238000001816 cooling Methods 0.000 description 8
- 239000006210 lotion Substances 0.000 description 8
- 239000008213 purified water Substances 0.000 description 8
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000003755 preservative agent Substances 0.000 description 6
- 230000002335 preservative effect Effects 0.000 description 6
- 229940058015 1,3-butylene glycol Drugs 0.000 description 5
- 235000019437 butane-1,3-diol Nutrition 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 238000012790 confirmation Methods 0.000 description 3
- 229960001484 edetic acid Drugs 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 210000000245 forearm Anatomy 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 210000004243 sweat Anatomy 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- NPTLAYTZMHJJDP-KTKRTIGZSA-N [3-[3-[3-[3-[3-[3-[3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)CO NPTLAYTZMHJJDP-KTKRTIGZSA-N 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 238000001931 thermography Methods 0.000 description 2
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 230000035597 cooling sensation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、メントール及び／又はメントール誘導体を含む油性成分を内相とした水中油型エマルションであり、エマルション径を微細にすることで、涼感成分配合量を多くすることなく、涼感効果を強くし、さらに塗布後、皮膚上で汗等の水分を得た場合に涼感効果を再び生じる涼感剤組成物に関するものである。 The present invention is an oil-in-water emulsion having an oily component containing menthol and / or a menthol derivative as an internal phase, and by making the emulsion diameter fine, the cool feeling effect is enhanced without increasing the amount of the cool feeling component. Furthermore, the present invention relates to a cool sensation agent composition that produces a cool feeling effect again when moisture such as sweat is obtained on the skin after application.
涼感成分を用いて皮膚に対して感覚的に清涼感を付与する場合、清涼感の強さや持続性は、化粧料における涼感成分の種類および配合量によって制御されている。しかし、清涼感を強くするために、涼感成分の配合量を高めると、涼感成分の種類によっては皮膚に塗布した場合に痛みなどの不快感を生じることがある。また、その不快感を生じさせないために、涼感成分の種類の変更および配合量を低くすると、清涼感およびその持続性が弱まることがある。これらのことから、清涼感を付与し、かつ持続性に優れた化粧料および外用剤の開発が望まれている。（特許文献１参照） When a refreshing sensation is imparted sensuously to the skin using a cool sensation component, the strength and persistence of the cool sensation are controlled by the type and amount of the cool sensation component in the cosmetic. However, if the amount of the cool sensation component is increased in order to enhance the refreshing sensation, discomfort such as pain may occur when applied to the skin depending on the type of the cool sensation component. Moreover, in order not to cause the unpleasant feeling, if the change of the kind and the compounding quantity of a cool feeling component are made low, a cool feeling and its sustainability may weaken. For these reasons, development of cosmetics and external preparations that impart a refreshing feeling and are excellent in sustainability is desired. (See Patent Document 1)
メントール及び／又はその誘導体と組み合わせることでより強く持続性がある涼感効果を生じる成分として、低級アルコールを配合することが報告されているが、油性成分をほとんど含まないローションでは低級アルコールを多く配合する必要があり、低級アルコールによる刺激性が懸念される。さらに多価アルコールを含有することが報告されているが、その化粧料は皮膚上で水分が蒸散した後に、汗等の水分を得た場合に、再び涼感を生じることについては言及されておらず、清涼感も満足いくものではなかった。（特許文献２、３参照） Although it has been reported that lower alcohol is added as a component that produces a stronger and lasting cool feeling effect by combining with menthol and / or its derivatives, lotion containing a lot of oily components contains a lot of lower alcohol. There is a concern that irritation caused by lower alcohols. Furthermore, although it is reported that polyhydric alcohol is contained, it is not mentioned that the cosmetic produces a cool feeling again when moisture such as sweat is obtained after the moisture has evaporated on the skin. The refreshing feeling was not satisfactory. (See Patent Documents 2 and 3)
本発明の目的は皮膚に対して清涼感を与え、汗をかいた時に清涼感を再び感じる涼感剤組成物およびこれを含有した皮膚または頭髪用外用剤を提供することにある。 An object of the present invention is to provide a cool sensation composition that gives a refreshing feeling to the skin and feels the refreshing feeling again when sweated, and an external preparation for skin or hair containing the same.
本発明者らは、本課題に対し、鋭意研究を行なった結果、（Ａ）糖アルコール、（Ｂ）メントール及び／又はその誘導体、（Ｃ）常温で液状の油性成分、（Ｄ）ポリグリセリン脂肪酸エステル、及び（Ｅ）水を含み、平均粒子径が４００ｎｍ以下である微細な水中油型エマルションであることを特徴とする涼感剤組成物およびこの涼感剤組成物を含有した皮膚または頭髪用外用剤とすることで、皮膚に対して清涼感を与え、汗をかいた時に清涼感を再び感じることができることを見出し、本発明を完成するに至った。
As a result of intensive studies on this problem, the present inventors have found that (A) sugar alcohol, (B) menthol and / or a derivative thereof, (C) an oily component that is liquid at room temperature, and (D) polyglycerin fatty acid. A cool sensation agent composition comprising an ester and (E) water and having an average particle size of 400 nm or less, and an external preparation for skin or hair containing the cool sensation agent composition As a result, it was found that a refreshing feeling can be given to the skin and a refreshing feeling can be felt again when sweating, and the present invention has been completed.
本発明により、皮膚に対して清涼感を与え、汗をかいた時に清涼感を再び感じる涼感剤組成物およびこれを含有した皮膚または頭髪用外用剤を提供することができる。
ADVANTAGE OF THE INVENTION By this invention, the refreshing agent composition which gives a refreshing feeling with respect to skin, and feels a refreshing feeling again when sweating, and the external preparation for skin or hair containing this can be provided.
以下、本発明の涼感剤組成物及びこれを配合した皮膚または頭髪用外用剤について詳述する。 Hereinafter, the cool sensation agent composition of the present invention and the external preparation for skin or hair containing the same will be described in detail.
本発明に用いる成分（Ａ）糖アルコールとしては、水溶解時の吸熱作用があるエリスリトール、キシリトール、ソルビトール、マンニトール、マルチトール、イソマルチトール、ラクチトール、ラクチュロール等が挙げられ、好ましくは特に溶解熱が大きいエリスリトール、キシリトールである。本発明においては、これらの１種または２種以上を用いることができる。涼感剤組成物中における配合量の質量比は、糖アルコール／水＝５／９５〜５０／５０であり、好ましくは１０／９０〜４０／６０、さらに好ましくは１５／８５〜３０／７０である。糖アルコール／水が、５／９５以上であれば、塗布後に汗等の水分を得た場合に十分満足な清涼感が得られ、５０／５０以下であれば低温においても析出等の問題が生じることもなく、使用性に問題はない。 Examples of the component (A) sugar alcohol used in the present invention include erythritol, xylitol, sorbitol, mannitol, maltitol, isomaltitol, lactitol, lactulol and the like, which have an endothermic action when dissolved in water, and preferably have a heat of dissolution. Great erythritol, xylitol. In the present invention, one or more of these can be used. The mass ratio of the blending amount in the cool sensation agent composition is sugar alcohol / water = 5/95 to 50/50, preferably 10/90 to 40/60, more preferably 15/85 to 30/70. . If the sugar alcohol / water is 5/95 or more, a sufficiently refreshing feeling can be obtained when moisture such as sweat is obtained after application, and if it is 50/50 or less, problems such as precipitation occur even at low temperatures. There is no problem in usability.
本発明に用いる成分（Ｂ）メントール及び／又はその誘導体としては、メンチルグリセリルエーテル、l−メンチルラクテート、１−メンチル−３−ヒドロキシブチレートなどが挙げられるが、特に好ましくは、ｌ‐メンチルラクテートである。涼感剤組成物中における配合量の質量比は、メントール及び／又はその誘導体／常温で液状の油性成分＝１／９９〜３０／７０が好ましく、より好ましくは３／９７〜２７．５／７２．５であり、さらに好ましくは５／９５〜２５／７５である。メントール及び／又はその誘導体／常温で液状の油性成分が、１／９９以上であれば、十分満足な清涼感が得られ、３０／７０以下であれば低温で析出等の問題を生じることもなく、使用性に問題はない。また、析出等を起こさせずに十分な清涼感が得られる量の成分（Ｂ）メントール及び／又はその誘導体を溶解させるためには、成分（Ｃ）常温で液状の油性成分が必要であるが、それらは、一般化粧品に使用される常温で液状の油性成分を用いることができ、油脂やエステル油などの極性油がより好ましい。 Examples of component (B) menthol and / or a derivative thereof used in the present invention include menthyl glyceryl ether, l-menthyl lactate, 1-menthyl-3-hydroxybutyrate, and the like. Particularly preferred is l-menthyl lactate. is there. The mass ratio of the blending amount in the cool sensation agent composition is preferably menthol and / or a derivative thereof / oil component which is liquid at normal temperature = 1/99 to 30/70, more preferably 3/97 to 27.5 / 72. 5, more preferably 5/95 to 25/75. Menthol and / or its derivatives / If the oily component that is liquid at room temperature is 1/99 or more, a sufficiently satisfactory refreshing feeling can be obtained, and if it is 30/70 or less, there is no problem such as precipitation at low temperatures. There is no problem in usability. In addition, in order to dissolve the component (B) menthol and / or its derivative in such an amount that a sufficient refreshing feeling can be obtained without causing precipitation or the like, the component (C) is an oily component that is liquid at room temperature. They can use oily components that are liquid at room temperature used in general cosmetics, and polar oils such as fats and oils are more preferred.
本発明に用いる成分（Ｄ）ポリグリセリン脂肪酸エステルは、ＨＬＢ１０以上であるポリグリセリン脂肪酸エステルから選ばれた１種以上が好ましく、より好ましくは炭素数１２〜２２の脂肪酸エステルでＨＬＢが１２〜１６のポリグリセリン脂肪酸エステルである。具体的には、モノラウリン酸ヘキサグリセリル、モノラウリン酸デカグリセリル、モノミリスチン酸ヘキサグリセリル、モノミリスチン酸デカグリセリル、モノパルミチン酸デカグリセリル、モノステアリン酸デカグリセリル、モノイソステアリン酸デカグリセリル、モノオレイン酸デカグリセリル、モノリノール酸デカグリセリルなどが挙げられる。本発明においては、これらの１種又は１種以上を用いることができる。これらのうち、より好ましいものは、モノラウリン酸デカグリセリル、モノミリスチン酸デカグリセリル、モノステアリン酸デカグリセリル、モノオレイン酸デカグリセリルである。 The component (D) polyglycerin fatty acid ester used in the present invention is preferably one or more selected from polyglycerin fatty acid esters having an HLB of 10 or more, more preferably a fatty acid ester having 12 to 22 carbon atoms and an HLB of 12 to 16. Polyglycerin fatty acid ester. Specifically, hexaglyceryl monolaurate, decaglyceryl monolaurate, hexaglyceryl monomyristate, decaglyceryl monomyristate, decaglyceryl monopalmitate, decaglyceryl monostearate, decaglyceryl monoisostearate, decaglyceryl monooleate And decaglyceryl monolinoleate. In the present invention, one or more of these can be used. Of these, more preferred are decaglyceryl monolaurate, decaglyceryl monomyristate, decaglyceryl monostearate, decaglyceryl monooleate.
本発明の涼感組成物は、微細な水中油型エマルションであり、平均粒子径が４００ｎｍ以下であり、好ましくは２００〜４００ｎｍである。平均粒子径を２００〜４００ｎｍの範囲とすることで、初期に感じる涼感効果をより高めることができる。 The cool sensation composition of the present invention is a fine oil-in-water emulsion and has an average particle size of 400 nm or less, preferably 200 to 400 nm. By setting the average particle size in the range of 200 to 400 nm, the cool feeling effect felt in the initial stage can be further enhanced.
本発明の涼感組成物の調製方法としては、特別な作業や特別な機械を使用することなく、ホモミキサーやパドルミキサー等の撹拌機能を有する通常の乳化機を用いて、通常の調製方法で調製することができる。 As a preparation method of the cool sensation composition of the present invention, it is prepared by a normal preparation method using a normal emulsifier having a stirring function such as a homomixer or a paddle mixer without using a special operation or a special machine. can do.
本発明の涼感組成物は、１〜５０質量％の範囲において、さらに好ましくは１０〜４０質量％の範囲にて、任意の皮膚外用剤や頭髪用外用剤に簡便に配合することが可能である。上記外用剤は、皮膚あるいは頭髪に適用する涼感外用剤であり、ローション、スプレーローション、シート含浸ローション、ミルクローション、ジェルローション、ジェルクリーム、クリーム、シャンプー、コンディショナー、ヘアセット剤などいかなる製剤においても簡便に配合することができ、特に限定されない。 The cool sensation composition of the present invention can be easily blended into any skin external preparation or hair external preparation in the range of 1 to 50% by mass, more preferably in the range of 10 to 40% by mass. . The above-mentioned external preparation is a cool sensation external preparation applied to the skin or hair, and can be easily used in any preparation such as lotion, spray lotion, sheet-impregnated lotion, milk lotion, gel lotion, gel cream, cream, shampoo, conditioner and hair set. There is no particular limitation.
以下に実施例を挙げて本発明を更に具体的に説明するが、本発明はこれらによって限定されるものではない。配合量は、質量％を表す。
The present invention will be described more specifically with reference to the following examples, but the present invention is not limited thereto. A compounding quantity represents the mass%.
涼感成分組成物の調製と評価 Preparation and evaluation of cool sensation component composition
（１）涼感成分組成物の調製
パドルミキサーおよび真空ポンプを装備した３リッターガラス製乳化機に、表１に示す各成分を、合計が１ｋｇになるように仕込み、乳化機内を２０〜３０ｍｍＨｇに減圧し、室温で１時間撹拌・混合を行い、均一な液体とした。
(1) Preparation of cool sensation component composition A 3 liter glass emulsifier equipped with a paddle mixer and a vacuum pump was charged with each component shown in Table 1 so that the total amount was 1 kg, and the inside of the emulsifier was reduced to 20-30 mmHg. The mixture was stirred and mixed at room temperature for 1 hour to obtain a uniform liquid.
（２）粒子径の測定
本発明の涼感組成物は、ベックマン・コールター（株）製のサブミクロン粒度分布測定装置（コールターＮ４ ＰＬＵＳ）を使用して平均粒子径（質量平均）を測定できる。
(2) Measurement of particle diameter The cool feeling composition of this invention can measure an average particle diameter (mass average) using the Beckman Coulter Co., Ltd. submicron particle size distribution measuring apparatus (Coulter N4 PLUS).
（３）安定性の測定
調製後、５℃恒温槽に静置し、２４時間後に析出物の有無を光学顕微鏡および目視により確認した。
◎：変化なし
○：やや不均一（使用には問題なし）
分離：２層に分離
(3) After measurement and preparation for stability, the sample was left in a 5 ° C. constant temperature bath, and after 24 hours, the presence or absence of precipitates was confirmed by an optical microscope and visual observation.
◎: No change ○: Slightly uneven (no problem in use)
Separation: separated into two layers
涼感成分組成物を含む外用剤の涼感効果 Cool effect of external preparation containing cool sensation component composition
（１）涼感組成物を含む外用剤の調製
パドルミキサーおよび真空ポンプを装備した３リッターガラス製乳化機に、表１で調製した涼感剤組成物および表２に示す各成分を、合計で１ｋｇになるように仕込み、乳化機内を２０〜３０ｍｍＨｇに減圧し、室温で１時間撹拌・混合を行い、均一な液体とした。表１で調製した比較例１は分離したため、外用剤の調製は実施しなかった。
(1) Preparation of external preparation containing cool sensation composition A 3 liter glass emulsifier equipped with a paddle mixer and a vacuum pump was mixed with the cool sensation agent composition prepared in Table 1 and each component shown in Table 2 to 1 kg in total. The pressure inside the emulsifier was reduced to 20-30 mmHg, and the mixture was stirred and mixed at room temperature for 1 hour to obtain a uniform liquid. Since Comparative Example 1 prepared in Table 1 was separated, preparation of the external preparation was not performed.
（２）初期の涼感の確認
１０名の被験者を用いて、表２に示した外用剤を被験者前腕に一定量塗布し、下記の通り官能評価を実施し、その平均点を涼感値とした。
５：涼感を強く感じる
４：涼感をやや感じる
３：涼感を少し感じる
２：涼感をほとんど感じない
１：涼感を全く感じない
(2) Confirmation of initial cool sensation Using 10 subjects, a certain amount of the external preparation shown in Table 2 was applied to the subject's forearm, sensory evaluation was performed as follows, and the average score was taken as the cool sensation value.
5: A strong feeling of coolness 4: A little feeling of cooling 3: A little feeling of cooling 2: A little feeling of cooling 1: A feeling of cooling not at all
（３）再涼感の確認（官能評価）
１０名の被験者を用いて、表２に示した外用剤を被験者前腕に一定量塗布し、乾燥後、一定量の水をスプレーにより塗布し、下記の通り官能評価を実施し、その平均点を涼感値とした。
５：涼感を強く感じる
４：涼感をやや感じる
３：涼感を少し感じる
２：涼感をほとんど感じない
１：涼感を全く感じない
(3) Confirmation of refreshing feeling (sensory evaluation)
Using 10 subjects, apply a certain amount of the external preparation shown in Table 2 to the subject's forearm, and after drying, apply a certain amount of water by spraying. The cool feeling value was used.
5: A strong feeling of coolness 4: A little feeling of cooling 3: A little feeling of cooling 2: A little feeling of cooling 1: A feeling of cooling not at all
（４）再涼感の確認（サーモグラフィー）
温度２５度、湿度５０％に設定した恒温恒湿室内において、被験者１名の洗浄タオルドライ後の前腕に表２に示した発明品１３〜２７および比較品４、５のそれぞれを比較品６と並べて一定量塗布した（２ｃｍ×２ｃｍ、０．２ｇ）。１０分間静置し、赤外線サーモグラフィ（ＦＬＩＲ Ｔ６００ フリアーシステムズジャパン株式会社製）を用いて両検体の表面温度が塗布前の状態に戻ったことを確認し、温度２５℃の精製水をスプレーにより一定量噴霧した。噴霧５分後のサーモグラフィ観察により、比較品６との表面温度差を涼感値とした。
In a constant temperature and humidity room set at a temperature of 25 ° C. and a humidity of 50%, each of the inventive products 13 to 27 and the comparative products 4 and 5 shown in Table 2 on the forearm after washing towel drying of one subject was compared with the comparative product 6. A fixed amount was applied side by side (2 cm × 2 cm, 0.2 g). Let stand for 10 minutes, use infrared thermography (FLIR T600 manufactured by FLIR Systems Japan Co., Ltd.) to confirm that the surface temperature of both specimens has returned to the state before application, and spray purified water at a temperature of 25 ° C by spraying. The amount was sprayed. The surface temperature difference from the comparative product 6 was defined as a cool feeling value by thermographic observation after 5 minutes of spraying.
以下に、本発明に係る涼感組成物を配合した皮膚および頭髪外用剤の応用例を挙げる。実施例３〜６で得られた応用品はいずれも涼感、再涼感効果が認められた。 Below, the application example of the skin and hair external preparation which mix | blended the cool feeling composition which concerns on this invention is given. All the applied products obtained in Examples 3 to 6 were found to have a cool feeling and a refreshing feeling effect.
涼感スプレーローション
１．１，３−ブチレングリコール ５．０
２．アクリル酸・メタクリル酸アルキル共重合体 ０．１
３．水酸化カリウム ０．０３
４．防腐剤 適量
５．精製水で１００．０質量％とする。
６．実施例１で得た本発明品６ ３０．０
（調製法） １〜５を均一に混合し、均一になったところで６を添加し、さらに撹拌し、均一になったところで終了する。
Cool feeling spray lotion 1.1,3-butylene glycol 5.0
2. Acrylic acid / alkyl methacrylate copolymer 0.1
3. Potassium hydroxide 0.03
4). Preservative appropriate amount 5. It is made 100.0 mass% with purified water.
6). Invention product 6 30.0 obtained in Example 1
(Preparation method) 1-5 are mixed uniformly, 6 will be added when it became uniform, and it will further stir, and will complete | finish when it becomes uniform.
涼感ジェル
１．アクリル酸・メタクリル酸アルキル共重合体 ０．３
２．１，３−ブチレングリコール ５．０
３．エデト酸２ナトリウム ０．０５
４．防腐剤 適量
５．精製水で１００．０質量％とする。
６．水酸化カリウム ０．１
７．精製水 ９．９
６．実施例１で得た本発明品１ ２０．０
（調製法）１〜５を均一に混合し、均一になったところで６，７を添加し、さらに撹拌し、均一になったところで８を添加し、さらに撹拌し均一になったところで終了する。
Cool gel 1 Acrylic acid / alkyl methacrylate copolymer 0.3
2. 1,3-butylene glycol 5.0
3. Edetic acid disodium 0.05
4). Preservative appropriate amount 5. It is made 100.0 mass% with purified water.
6). Potassium hydroxide 0.1
7). Purified water 9.9
6). Invention product 1 obtained in Example 1 20.0
(Preparation method) 1 to 5 are uniformly mixed. When the mixture becomes uniform, 6 and 7 are added, and the mixture is further stirred. When the mixture becomes uniform, 8 is added, and the mixture is further stirred and the mixture is finished.
涼感乳液
１．ヒドロキシエチルセルロース ０．３
２．キサンタンガム ０．２
３．ヒアルロン酸ナトリウム ０．０１
４．１，３−ブチレングリコール ３．０
５．グリセリン ２．０
６．エデト酸２ナトリウム ０．０５
７．防腐剤 適量
８．精製水で１００．０質量％とする。
９．実施例１で得た本発明品７ １０．０
（調製法）１〜８を混合し、均一になったところで９を添加し、さらに撹拌する。均一になったところで調製を終了する。
Cool emulsion 1 Hydroxyethyl cellulose 0.3
2. Xanthan gum 0.2
3. Sodium hyaluronate 0.01
4.1,3-Butylene glycol 3.0
5. Glycerin 2.0
6). Edetic acid disodium 0.05
7). Preservative appropriate amount 8. It is made 100.0 mass% with purified water.
9. Invention product 7 obtained in Example 1 10.0
(Preparation method) 1 to 8 are mixed, and when it becomes uniform, 9 is added and further stirred. When it becomes uniform, the preparation is finished.
シート含浸ローション
１．ヒドロキシエチルセルロース ０．３
２．ジプロピレングリコール ３．０
３．エデト酸２ナトリウム ０．０５
４．防腐剤 適量
５．精製水で１００．０質量％とする。
６．実施例１で得た本発明品１０ ４０．０
（調製法）１〜５を混合し、均一になったところで６を添加し、さらに撹拌する。均一になったところでシートに含浸させ充填し、調製を終了する。
Sheet impregnation lotion Hydroxyethyl cellulose 0.3
2. Dipropylene glycol 3.0
3. Edetic acid disodium 0.05
4). Preservative appropriate amount 5. It is made 100.0 mass% with purified water.
6). Invention product 10 obtained in Example 1 40.0
(Preparation method) 1 to 5 are mixed, and when uniform, 6 is added and further stirred. When uniform, the sheet is impregnated and filled, and the preparation is completed.
涼感シャンプー
１．ラウレス硫酸ナトリウム １０．０
２．コカミドプロピルベタイン ５．０
３．コカミドジエタノールアミド ３．０
４．１，３−ブチレングリコール ５．０
５．防腐剤 適量
６．精製水で１００．０質量％とする。
７．実施例１で得た本発明品１２ ２０．０
（調製法）１〜６を混合し、均一になったところで７を添加し、さらに撹拌する。均一になったところで調製を終了する。
Cool shampoo 1. Sodium laureth sulfate 10.0
2. Cocamidopropyl betaine 5.0
3. Cocamide diethanolamide 3.0
4.1,3-Butylene glycol 5.0
5. Preservative appropriate amount 6. It is made 100.0 mass% with purified water.
7). Invention product 12 obtained in Example 1 20.0
(Preparation method) 1 to 6 are mixed, and when uniform, 7 is added and further stirred. When it becomes uniform, the preparation is finished.
涼感コンディショナー
１．ポリオキシエチレンベヘニルエーテル ０．５
２．モノステアリン酸グリセリル １．０
３．塩化ステアリルトリメチルアンモニウム ０．５
４．セトステアリルアルコール ４．０
５．ミリスチン酸イソプロピル ３．０
６．ヒドロキシエチルセルロース ０．５
７．１，３−ブチレングリコール ５．０
８．防腐剤 適量
９．精製水で１００．０質量％とする。
１０．実施例１で得た本発明品１ １５．０
（調製法）８０度において１〜５、６〜９をそれぞれ均一にする。８０度において６〜９に１〜５を加え乳化し、撹拌冷却する。３５度になったところで１０を加え均一にし、調製を終了する。
Cool conditioner 1. Polyoxyethylene behenyl ether 0.5
2. Glyceryl monostearate 1.0
3. Stearyltrimethylammonium chloride 0.5
4). Cetostearyl alcohol 4.0
5. Isopropyl myristate 3.0
6). Hydroxyethyl cellulose 0.5
7.1,3-Butylene glycol 5.0
8). Preservative appropriate amount 9. It is made 100.0 mass% with purified water.
10. Invention product 1 obtained in Example 1 15.0
(Preparation method) 1 to 5 and 6 to 9 are made uniform at 80 degrees, respectively. Add 1-5 to 6-9 at 80 degrees, emulsify and cool with stirring. When the temperature reaches 35 degrees, 10 is added to make uniform, and the preparation is completed.
本発明の目的は皮膚に対して清涼感を与え、汗をかいた時に清涼感を再び感じる涼感剤組成物およびこれを含有した皮膚または頭髪用外用剤に関する。 The object of the present invention relates to a cooling sensation composition that gives a refreshing feeling to the skin and feels the refreshing feeling again when sweated, and an external preparation for skin or hair containing the same.
Claims (4)
（Ａ）キシリトール、エリスリトール、ソルビトール、マンニトール、マルチトール、ラクチトール、イソマルチトール、ラクチュロールから選ばれた１種以上の糖アルコール
（Ｂ）メントール及び／又はメンチルグリセリルエーテル、ｌ−メンチルラクテート、１−メンチル−３−ヒドロキシブチレートから選ばれる１種または２種以上の誘導体
（Ｃ）常温で液状の油性成分
（Ｄ）ポリグリセリン脂肪酸エステル
（Ｅ）水
上記（Ａ）〜（Ｅ）の成分の配合比が、成分（Ａ）糖アルコール／成分（Ｅ）水＝５／９５〜５０／５０、成分（Ｂ）メントール及び／又はその誘導体／成分（Ｃ）常温で液状の油性成分＝１／９９〜３０／７０であることを特徴とする微細な水中油型エマルションタイプの涼感剤組成物。 In the cooling agent composition blended in the external preparation for the purpose of imparting a cool feeling, the average particle size containing the following (A) to (E) as essential components is 400 nm or less,
(A) One or more sugar alcohols selected from xylitol, erythritol, sorbitol, mannitol, maltitol, lactitol, isomaltitol, lactulol (B) menthol and / or menthyl glyceryl ether, l-menthyl lactate, 1-menthyl One or more derivatives selected from -3-hydroxybutyrate (C) Oily component that is liquid at normal temperature (D) Polyglycerin fatty acid ester (E) Water Mixing ratio of components (A) to (E) above Component (A) sugar alcohol / component (E) water = 5 / 95-50 / 50, component (B) menthol and / or its derivative / component (C) oily component which is liquid at normal temperature = 1 / 99-30 A fine oil-in-water emulsion type cool sensation composition characterized by being / 70.
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| JP6999288B2 (en) * | 2016-04-20 | 2022-02-10 | 太陽化学株式会社 | Composition for hair cleanser |
| CN106038416B (en) * | 2016-07-19 | 2019-04-16 | 欧标（广州）化妆品有限公司 | A kind of cooling composition and drug and cosmetics containing cooling composition |
| JP7742627B2 (en) * | 2021-05-27 | 2025-09-22 | 株式会社日本色材工業研究所 | Two-layer separated cosmetics |
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| JP4584340B2 (en) * | 2009-04-27 | 2010-11-17 | 株式会社資生堂 | Oil-in-water emulsified hair cosmetic |
| JP5227467B2 (en) * | 2011-02-28 | 2013-07-03 | 株式会社 資生堂 | Transparent or translucent oil-in-water emulsified cosmetics |
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