JP3615001B2 - Skin cosmetics - Google Patents
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- JP3615001B2 JP3615001B2 JP30134996A JP30134996A JP3615001B2 JP 3615001 B2 JP3615001 B2 JP 3615001B2 JP 30134996 A JP30134996 A JP 30134996A JP 30134996 A JP30134996 A JP 30134996A JP 3615001 B2 JP3615001 B2 JP 3615001B2
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- birch
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- 239000002537 cosmetic Substances 0.000 title claims description 12
- 230000009759 skin aging Effects 0.000 claims description 9
- 235000003932 Betula Nutrition 0.000 claims description 6
- 241000219429 Betula Species 0.000 claims description 6
- 241000219495 Betulaceae Species 0.000 claims description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000419 plant extract Substances 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- DGMPVYSXXIOGJY-UHFFFAOYSA-N Fusaric acid Chemical compound CCCCC1=CC=C(C(O)=O)N=C1 DGMPVYSXXIOGJY-UHFFFAOYSA-N 0.000 claims 2
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims 2
- XZHWAGZSWOAEPI-UHFFFAOYSA-N C(C=CC1=CC(O)=C(O)C=C1)(=O)O.OC=1C=C(C=CC(=O)O)C=CC1O Chemical compound C(C=CC1=CC(O)=C(O)C=C1)(=O)O.OC=1C=C(C=CC(=O)O)C=CC1O XZHWAGZSWOAEPI-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940124277 aminobutyric acid Drugs 0.000 claims 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 description 19
- 210000003491 skin Anatomy 0.000 description 17
- 235000018185 Betula X alpestris Nutrition 0.000 description 9
- 235000018212 Betula X uliginosa Nutrition 0.000 description 9
- 239000000284 extract Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 239000006210 lotion Substances 0.000 description 5
- 235000002992 Betula pubescens Nutrition 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- 229940061720 alpha hydroxy acid Drugs 0.000 description 4
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000219496 Alnus Species 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 235000009109 Betula pendula Nutrition 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 230000037336 dry skin Effects 0.000 description 3
- 230000002500 effect on skin Effects 0.000 description 3
- 210000001339 epidermal cell Anatomy 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000007306 turnover Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 241001564262 Alnus hirsuta Species 0.000 description 2
- 244000274847 Betula papyrifera Species 0.000 description 2
- 235000009113 Betula papyrifera Nutrition 0.000 description 2
- 235000002359 Betula platyphylla var japonica Nutrition 0.000 description 2
- 241001606229 Betula platyphylla var. japonica Species 0.000 description 2
- 235000010928 Betula populifolia Nutrition 0.000 description 2
- 241001520764 Betula pubescens Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 240000000643 Alnus japonica Species 0.000 description 1
- 241001564389 Alnus matsumurae Species 0.000 description 1
- 241001350596 Alnus trabeculosa Species 0.000 description 1
- 235000018225 Asian white birch Nutrition 0.000 description 1
- 235000012283 Betula kenaica Nutrition 0.000 description 1
- 241000073353 Betula kenaica Species 0.000 description 1
- 241000219430 Betula pendula Species 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000008341 cosmetic lotion Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
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- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
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- 239000001630 malic acid Substances 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
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- -1 packs Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
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- Cosmetics (AREA)
Description
【０００１】
【発明の属する技術分野】
本発明は皮膚老化防止効果（表皮細胞の増殖、分化の促進、角質層のターンオーバー促進、角質改善、保湿効果、美肌効果など）に優れた化粧料に関する。
【０００２】
【従来の技術及び課題】
老化皮膚では、表皮及び真皮の細胞活性の低下が見られ、そのため角質層の機能低下による乾燥肌や真皮繊維芽細胞の機能低下による弾力性のない肌になる。このような、老化皮膚の活性を回復させるために、細胞賦活剤の探索が行われ、その結果、カバノキ科のカバノキ属に属するシラカンバ、ハンノキ属に属するハンノキの抽出エキスに表皮細胞の増殖を顕著に促進し、角質層の機能を改善する作用があることが開示されている。（特開平６−２６３６２７号公報）
また、特開平５−１３９９４７号公報には、α−ヒドロキシ酸類も表皮のターンオーバーを促進したり、皮膚柔軟性を向上させるなど老化症状の防止、改善や肌荒れ症状の防止、改善する作用があることが開示されているが、α−ヒドロキシ酸類の配合量を多くすると安定な製剤化が困難になったり、皮膚刺激性が出現するなどの問題がある。 従ってより有効で安全性の高い皮膚老化防止用化粧料の開発が望まれていた。
【０００３】
【課題を解決するための手段】
本発明者らは、皮膚老化防止効果を改善、向上させるべく鋭意研究を重ねたところ、遂に、カバノキ科のカバノキ属に属する植物、又はハンノキ属に属する植物の抽出エキスと炭素数が２〜４のα−ヒドロキシ酸およびその誘導体から選ばれる１種以上を配合することにより、皮膚老化防止効果（表皮細胞の増殖、分化の促進、角質層のターンオーバー促進、角質改善、保湿効果、美肌効果など）が相乗的に改善、向上することを見出し、本発明の完成に至った。
【０００４】
【発明の実施の形態】
本発明に用いるカバノキ科カバノキ属植物抽出物は、例えばシラカンバ（Ｂｅｔｕｌａ ｐｌａｔｙｐｈｙｌｌａ ｖａｒ．ｊａｐｏｎｉｃａ）、コウアンシラカンバ（Ｂｅｔｕｌａ ｐｌａｔｙｐｈｙｌｌａ ｖａｒ．ｐｌａｔｙｐｈｙｌｌａ）、シセンカンバ（Ｂｅｔｕｌａ ｐｌａｔｙｐｈｙｌｌａ ｖａｒ．ｓｚｅｃｈａｎｉｃａ）、ヨーロッパシラカンバ（Ｂｅｔｕｌａ ｐｅｎｄｕｌａ）、ケカンバ（Ｂｅｔｕｌａ ｐｕｂｅｓｃｅｎｓ）、トルトーサカンバ（Ｂｅｔｕｌａ ｐｕｂｅｓｃｅｎｓ ｖａｒ．ｔｏｒｔｕｏｓａ）、イベリアカンバ（Ｂｅｔｕｌａ ｃｅｒｔｉｂｅｒｉｃａ）、べトゥラ・パピリフィラ（Ｂｅｔｕｌａ ｐａｐｙｒｉｆｅｒａ）、べトゥラ・ケナイカ（Ｂｅｔｕｌａ ｋｅｎａｉｃａ）、べトゥラ・ポプリフォリア（Ｂｅｔｕｌａ ｐｏｐｕｌｉｆｐｌｉａ）等からの抽出物である。また、同科のハンノキ属植物抽出物は、例えばハンノキ（Ａｌｎｕｓ ｊａｐｏｎｉｃａ）、エゾハンノキ（ヤチハンノキ）（Ａｌｎｕｓ ｊａｐｏｎｉｃａ ｖａｒ．ａｒｇｕｔａ）、サクラバハンノキ（Ａｌｎｕｓ ｔｒａｂｅｃｕｌｏｓａ）、ネパールハンノキ（Ａｌｎｕｓ ｎｅｐａｌｅｎｓｉｓ）、ケヤマハンノキ（Ａｌｎｕｓ ｈｉｒｓｕｔａ）、ヤマハンノキ（Ａｌｎｕｓ ｈｉｒｓｕｔａ ｖａｒ．ｓｉｂｉｒｉｃａ）、ヤハズハンノキ（Ａｌｎｕｓ ｍａｔｓｕｍｕｒａｅ）、コバノヤマハンノキ（タニガワハンノキ）（Ａｌｎｕｓ ｉｎｏｋｕｍａｅ）、カワラハンノキ（Ａｌｎｕｓ ｓｅｒｒｕｌａｔｏｉｄｅｓ）等の抽出物である。これらの植物の内、特にシラカンバ（Ｂｅｔｕｌａ ｐｌａｔｙｐｈｙｌｌａ ｖａｒ．ｊａｐｏｎｉｃａ）、コウアンシラカンバ（Ｂｅｔｕｌａ ｐｌａｔｙｐｈｙｌｌａ ｖａｒ．ｐｌａｔｙｐｈｙｌｌａ）、ヨーロッパシラカンバ（Ｂｅｔｕｌａ ｐｅｎｄｕｌａ）が好ましい。
【０００５】
これらの抽出物は、該植物の葉、木部、樹皮等いずれの部位でも使用でき、中でも樹皮が好ましい。抽出溶媒は特に限定されないが、ベンゼン、エチルエーテル、クロロホルム、酢酸エチル、酢酸ブチル、アセトン、メタノール、エタノール又は１、３−ブチレングリコール、及び水等が例示でき、特にエタノール、水が好ましい。これらの抽出溶媒は１種又は２種以上の混合溶媒を用いることもできる。抽出操作は常法により行われ、抽出液をそのままで用いることができ、また抽出液を濃縮した軟エキス、さらに蒸発乾固した抽出末などの形状で配合できる。
【０００６】
これらの抽出物の配合量は、化粧料全量に対し０．００１〜１０重量％、特に０．０１〜５重量％が好ましい。配合量が０．００１重量％未満であると皮膚老化防止効果が充分に発揮できない。また、１０重量％を越えて配合しても、それ以上の皮膚老化防止効果の向上が認められない。
【０００７】
本発明に用いる炭素数２〜４のα−ヒドロキシ酸類は、グリコール酸、乳酸、リンゴ酸、酒石酸などが挙げられる。これらのαーヒドロキシ酸類は、その１種以上配合することができ、その配合量は化粧料全量に対して０．０１〜１５重量％である。配合量が０．０１重量％に満たないと老化防止効果が期待できず、また、１５重量％を超えて配合しても、それ以上の効果が期待出来ないばかりか、皮膚激が生じ好ましくない。
【０００８】
本発明の皮膚化粧料は、常法によりクリーム、化粧水、美容液、パック、洗浄料など通常の化粧料の形態で供することができ、特に化粧水、美容液などの非乳化製剤が好ましい。さらに、本発明では、それぞれの形態に応じて、本発明の効果を損なわない範囲において適宜公知の基剤、色素、香料、防腐剤、界面活性剤、抗酸化剤等を配合することができる。
【０００９】
【実施例】
以下、実施例及び比較例に基づいて本発明を詳細に説明するが、本発明はこれらに限定されるものではない。また、特に断らない限り［％］は［重量％］を示す。表１に示すローションを調製し、皮膚老化防止効果（保湿効果、美肌効果）を評価した。評価方法を示す。
【００１０】
１． 保湿効果試験
荒れ肌、小じわ、乾燥肌等を訴える中高年被験者２０人の頬部に実施例１〜２、比較例１〜３のローションを連続４週間塗布し、頬部の水分量をインピーダンスメーター（ＳＫＩＣＯＮ−２００：ＩＢＳ社製）を用いて測定し、下式により水分増加率を算出した。水分増加率が大きいほど有効である。
【００１１】
【数１】
２．美肌効果
荒れ肌、子じわ、乾燥肌等を訴える女子被験者（３０〜５０代）２０人に実施例１〜２、比較例１〜３のローションを１日２回（朝、夕）連続３ヶ月塗布して、３ヶ月後の効果を測定した。測定には、適用部位のレプリカを用いた画像解析法を用いた。
測定方法を示す。それぞれの被験者について、実施例（比較例）適用部位のレプリカを作成、これらをマイクロスコープ（ＨＩ−ＳＣＯＰＥ ＭＯＤＥＬ ＫＨ−２２００ ＭＤ２：ＨＩＲＯＸ製）により観察し、画像解析装置（ＡＶＩＯ ＥＸＣＥＬ：ＮＩＰＰＯＮ ＡＶＩＯＮＩＣＳ製）に取り込んだ画像を統計解析した。
美肌効果は、一定面積内のキメの数をラベリングしてあらわした。ここでは、一定面積内のキメ（画像上で皮溝に囲まれた領域）の増加率（％）が大きいほど美肌効果がある。
【００１３】
【数２】
【表１】
【００１６】
【００１７】
【００１８】
【００１９】
【発明の効果】
以上記載のように、本発明は保湿効果、美肌効果等を有し、皮膚機能を改善し、皮膚の老化防止に優れた効果を発揮する。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a cosmetic excellent in anti-aging effects on skin (such as proliferation of epidermal cells, promotion of differentiation, promotion of turnover of stratum corneum, improvement of keratin, moisturizing effect, skin beautifying effect, etc.).
[0002]
[Prior art and problems]
In aging skin, cell activity of the epidermis and dermis is reduced, and therefore, dry skin due to a decrease in the function of the stratum corneum and inelastic skin due to a decrease in the function of dermal fibroblasts. In order to restore the activity of aging skin, the search for cell activators was conducted, and as a result, the growth of epidermal cells was remarkable in the extract of birch belonging to the birch genus of the birch family, alder belonging to the genus Alder. It is disclosed that it has an action to promote and improve the function of stratum corneum. (JP-A-6-263627)
Further, in JP-A-5-139947, α-hydroxy acids also have an action of preventing and improving aging symptoms and preventing and improving rough skin symptoms such as promoting the turnover of the epidermis and improving skin flexibility. However, when the amount of α-hydroxy acids is increased, there is a problem that stable formulation becomes difficult and skin irritation appears. Therefore, development of a more effective and safer skin aging prevention cosmetic has been desired.
[0003]
[Means for Solving the Problems]
The inventors of the present invention have intensively studied to improve and improve the effect of preventing skin aging. Finally, an extract of a plant belonging to the genus Birch genus of the birch family or a plant belonging to the genus Alder has 2 to 4 carbon atoms. Skin aging prevention effect (proliferation of epidermal cells, promotion of differentiation, promotion of turnover of stratum corneum, improvement of keratin, moisturizing effect, skin beautifying effect, etc.) ) Synergistically improved and improved, and the present invention was completed.
[0004]
DETAILED DESCRIPTION OF THE INVENTION
For example, birch (Betula platyphylla var. Japonica), bivala phylla var. (Betula pubescens), Tortosa birch (Betula pubescens var.tortuosa), Iberian birch (Betula ceriveberica), Betula papyrifira (Betula puberifera), Betula kenaica (Betula kena) It is an extract from (Betula populiferia) and the like. In addition, the plant extracts of the same genus are, for example, Alnus japonica, Ezo alder tree (Alnus janeca var. Arguta), Alnus trabeculosa, Alnus ner al al nsalp. , Alnus hirsuta var. Sibirica, Alnus matsumurae, Alnus inokumae, Alnus serrato, etc. Among these plants, white birch (Betula platyphylla var. Japonica), white birch (Betula platyphylla var. Platyphylla), and European birch (Betula pendula) are particularly preferable.
[0005]
These extracts can be used at any site such as leaves, xylem and bark of the plant, and bark is preferable among them. The extraction solvent is not particularly limited, and examples thereof include benzene, ethyl ether, chloroform, ethyl acetate, butyl acetate, acetone, methanol, ethanol or 1,3-butylene glycol, and water, and ethanol and water are particularly preferable. These extraction solvents can also use 1 type, or 2 or more types of mixed solvents. The extraction operation is carried out by a conventional method, and the extract can be used as it is, and can also be blended in the form of a soft extract obtained by concentrating the extract and further evaporating to dryness.
[0006]
The blending amount of these extracts is preferably 0.001 to 10% by weight, particularly 0.01 to 5% by weight, based on the total amount of the cosmetic. If the blending amount is less than 0.001% by weight, the effect of preventing skin aging cannot be exhibited sufficiently. Moreover, even if it exceeds 10% by weight, no further improvement in the effect of preventing skin aging is observed.
[0007]
Examples of the α-hydroxy acids having 2 to 4 carbon atoms used in the present invention include glycolic acid, lactic acid, malic acid, and tartaric acid. One or more of these α-hydroxy acids can be blended, and the blending amount is 0.01 to 15% by weight based on the total amount of the cosmetic. If the blending amount is less than 0.01% by weight, an anti-aging effect cannot be expected, and if it exceeds 15% by weight, not only a further effect cannot be expected, but also skin irritation occurs, which is not preferable. .
[0008]
The skin cosmetics of the present invention can be provided in the form of ordinary cosmetics such as creams, lotions, cosmetic liquids, packs, and cleaning agents by conventional methods, and non-emulsifying preparations such as cosmetic lotions and cosmetic liquids are particularly preferred. Furthermore, in this invention, according to each form, in the range which does not impair the effect of this invention, a well-known base, a pigment | dye, a fragrance | flavor, antiseptic | preservative, surfactant, antioxidant etc. can be mix | blended suitably.
[0009]
【Example】
EXAMPLES Hereinafter, although this invention is demonstrated in detail based on an Example and a comparative example, this invention is not limited to these. Unless otherwise specified, [%] indicates [% by weight]. Lotions shown in Table 1 were prepared and evaluated for skin aging prevention effects (moisturizing effect, skin beautifying effect). The evaluation method is shown.
[0010]
1. Moisturizing effect test The lotions of Examples 1 and 2 and Comparative Examples 1 to 3 were applied to the cheeks of 20 middle-aged and elderly subjects complaining of rough skin, fine wrinkles, dry skin, etc., and the moisture content of the cheeks was measured with an impedance meter (SKICON) -200: manufactured by IBS), and the water increase rate was calculated by the following formula. The greater the moisture increase rate, the more effective.
[0011]
[Expression 1]
2. Beautiful skin effect 20 female subjects (30-30s) complaining of rough skin, wrinkles, dry skin etc. The lotions of Examples 1-2 and Comparative Examples 1-3 are given twice a day (morning and evening) for 3 consecutive months After application, the effect after 3 months was measured. For the measurement, an image analysis method using a replica of the application site was used.
The measurement method is shown. For each subject, a replica of the application site of the example (comparative example) was created, and these were observed with a microscope (HI-SCOPE MODEL KH-2200 MD2: manufactured by HIROX), and image analysis apparatus (AVIO EXCEL: manufactured by NIPPON AVIIONICS) Statistical analysis of the images taken in
The skin beautifying effect was expressed by labeling the number of textures within a certain area. Here, as the increase rate (%) of the texture (area surrounded by the skin groove on the image) within a certain area increases, the skin beautifying effect is obtained.
[0013]
[Expression 2]
[Table 1]
[0016]
[0017]
[0018]
[0019]
【The invention's effect】
As described above, the present invention has a moisturizing effect, a skin beautifying effect, etc., improves skin function, and exhibits excellent effects in preventing skin aging.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30134996A JP3615001B2 (en) | 1996-10-24 | 1996-10-24 | Skin cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30134996A JP3615001B2 (en) | 1996-10-24 | 1996-10-24 | Skin cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH10130133A JPH10130133A (en) | 1998-05-19 |
| JP3615001B2 true JP3615001B2 (en) | 2005-01-26 |
Family
ID=17895803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP30134996A Expired - Fee Related JP3615001B2 (en) | 1996-10-24 | 1996-10-24 | Skin cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3615001B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001072568A (en) * | 1999-09-07 | 2001-03-21 | Sunstar Inc | Skin cosmetic |
| JP3877914B2 (en) * | 1999-09-07 | 2007-02-07 | サンスター株式会社 | Skin cosmetics |
| JP5171097B2 (en) * | 2007-04-17 | 2013-03-27 | 花王株式会社 | Heparin-binding epidermal growth factor-like growth factor gene expression promoter containing plant extract |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH069370A (en) * | 1992-06-29 | 1994-01-18 | Tsumura & Co | Bathing agent composition |
| JPH07206665A (en) * | 1994-01-13 | 1995-08-08 | Lion Corp | Bath agent composition |
| FR2736263B1 (en) * | 1995-07-07 | 1997-09-26 | C3D Sarl | DEPIGMENTING DERMOCOSMETIC COMPOSITION AND ITS USE |
-
1996
- 1996-10-24 JP JP30134996A patent/JP3615001B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10130133A (en) | 1998-05-19 |
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