JP3282840B2 - Composition for improving long-distance running ability - Google Patents
Composition for improving long-distance running abilityInfo
- Publication number
- JP3282840B2 JP3282840B2 JP31411491A JP31411491A JP3282840B2 JP 3282840 B2 JP3282840 B2 JP 3282840B2 JP 31411491 A JP31411491 A JP 31411491A JP 31411491 A JP31411491 A JP 31411491A JP 3282840 B2 JP3282840 B2 JP 3282840B2
- Authority
- JP
- Japan
- Prior art keywords
- running
- distance
- composition
- extract
- reishi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims description 9
- 240000008397 Ganoderma lucidum Species 0.000 claims description 21
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims description 21
- 230000000694 effects Effects 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000008399 tap water Substances 0.000 description 7
- 235000020679 tap water Nutrition 0.000 description 7
- 241000222336 Ganoderma Species 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 238000007912 intraperitoneal administration Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 2
- 235000019152 folic acid Nutrition 0.000 description 2
- 239000011724 folic acid Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 150000002482 oligosaccharides Chemical class 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010049565 Muscle fatigue Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000005976 liver dysfunction Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は長距離走能力改善用組成
物に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for improving long-distance running ability.
【０００２】[0002]
【従来の技術】飲食品としての霊芝は、いわゆる「健康
食品」として、あるいは特定の医薬的目的、例えば高脂
血症時のコレステロール量の改善、動脈硬化の予防、血
圧降下作用、血圧上昇作用、糖尿病の改善、胆石の抑
制、大腸ガンの予防、老人性痴呆症の改善、肝機能障害
の改善などの目的で用いられてきた。2. Description of the Related Art Reishi as a food or drink is used as a so-called "health food" or for a specific medical purpose, for example, improvement of cholesterol level in hyperlipidemia, prevention of arteriosclerosis, hypotensive action, elevated blood pressure. It has been used for the purpose of action, improvement of diabetes, suppression of gallstones, prevention of colorectal cancer, improvement of senile dementia, improvement of liver dysfunction and the like.
【０００３】[0003]
【発明が解決しようとする課題】一方、本発明者らは、
かねてより長距離走能力の向上を体力科学的見地から検
討する手法を確立しており、特に、霊芝成分による長距
離走能力向上効果について種々の角度から検討を続けて
きた。従って本発明の目的は長距離走能力改善効果を有
する霊芝含有組成物を提供することにある。On the other hand, the present inventors have
A method has been established to study the improvement of long-distance running ability from a physical science point of view. In particular, the long-distance running ability improvement effect of Reishi components has been studied from various angles. Accordingly, an object of the present invention is to provide a reishi-containing composition having an effect of improving long-distance running ability.
【０００４】[0004]
【課題を解決するための手段】上記目的を達成した本発
明の長距離走能力改善用組成物は、霊芝の熱水抽出物を
含有するところに特徴がある。The composition for improving long-distance running ability of the present invention which achieves the above object is characterized by containing a hot water extract of Reishi.
【０００５】[0005]
【作用】本発明の組成物には、霊芝のエキスを配合した
ものの他、霊芝の破砕品を配合したものを包含し、霊芝
のどの部分、例えば傘部分のみを使用しているか子実体
全てを使用しているか否か、さらには液体状であるか固
体状であるか等を問うものではない。The composition of the present invention includes, in addition to those containing the extract of Ganoderma lucidum, those containing the crushed product of Ganoderma lucidum. It does not matter whether all the entities are used or not, whether they are liquid or solid.
【０００６】本発明者らは、霊芝による持久力向上効果
を調査するため、マウス及びラットを用いて自発的にあ
るいは強制的に走行させ、その走行可能距離が霊芝エキ
スを与えた場合（本発明例）と単に水道水を与えた場合
（対照）とで比較した。自発的に走行させる場合は回転
カゴに入れて１日当りの自由走行距離を測定した。強制
的に走行させる場合は、トレッドミル走行装置（回転す
るベルトの後方に電気ショックを与える装置を設けてあ
り、ベルト上の動物はベルトの動きに合わせて強制的に
走行させられる）を用いて試験動物が倒れる迄にどれだ
けの距離を走行したかを測定した。尚、後者の場合は各
試験動物群毎に霊芝エキス又は水道水を与えながら８週
間の走行トレーニングを積んだ後に試験を行った。後述
する実験例で示す様に、いずれの場合においても、霊芝
エキスを与えた群の方が、水道水を与えた群よりも走行
距離が長かった。また自由飲水投与でなく腹腔内投与や
胃内投与でも霊芝エキスを与えた群の方が生食水や水道
水を与えた群よりも走行距離を伸ばした。これらの結果
から霊芝エキスを投与することにより、筋肉労働におけ
る何らかの代謝が改善され、その結果として持久力が高
められるに至ったものであると考えられ、霊芝成分が持
久力を必要とする広義の有酸素運動に効力を示すことを
示している。[0006] The present inventors investigated the endurance-improving effect of Ganoderma lucidum by using mice and rats to run spontaneously or forcibly, and given the distance that the mosquitoes could be run with Ganoderma extract ( The present invention example) was compared with the case where tap water was simply provided (control). In the case of running spontaneously, the free running distance per day was measured in a rotating basket. In the case of forcibly running, a treadmill running device (a device for applying an electric shock behind the rotating belt is provided, and the animal on the belt is forcibly driven according to the movement of the belt) is used. The distance traveled before the test animal collapsed was measured. In the latter case, the test was carried out after running test for 8 weeks while giving a reishi extract or tap water to each test animal group. As shown in the experimental examples described later, in all cases, the group given the reishi extract had a longer running distance than the group given tap water. In addition, in the group administered with Ganoderma extract, the mileage was longer than that in the group administered with saline or tap water, not only by intraperitoneal administration or intragastric administration but also by free water administration. Based on these results, it is thought that administration of Ganoderma extract improved some metabolism in muscle labor, and as a result, increased endurance, and the Ganoderma component required endurance. It shows that it is effective for aerobic exercise in a broad sense.
【０００７】[0007]
【実施例】本発明に係る霊芝成分含有の持久力改善飲食
品は、霊芝エキス（例えば10% 熱水抽出品を使用する）
の他、還元麦芽糖、オリゴ糖、葉酸、ビタミンＣ、ビタ
ミンＢ12、鉄分等を含有することが可能で、もっとも代
表的なものはドリンクである。代表的な組成を示すと、
霊芝ドリンク１００ｍｌ中には、 霊芝エキス（10％熱水抽出） 75− 90ｍｌ 還元麦芽糖 ５− 5.5ｍｌ オリゴ糖 2.5− 3.5ｍｌ 葉酸 １− 2.5ｍｌ ビタミンＣ １− 2.5ｍｌ ビタミンＢ12 １− 2.5ｍｌ 鉄分 １− 2.5ｍｌ を含有している。EXAMPLE The endurance-improving food or drink containing a reishi component according to the present invention is a reishi extract (for example, using a 10% hot water extract).
In addition, it is possible to contain reduced maltose, oligosaccharides, folic acid, vitamin C, vitamin B 12 , iron, etc., and the most typical one is a drink. When showing a typical composition,
During ganoderma drink 100 ml, ganoderma extract (10% heat-water extract) 75- 90 ml reduced maltose 5-5.5 ml oligosaccharide 2.5- 3.5 ml folate 1-2.5 ml vitamin C 1-2.5 ml vitamin B 12 1-2.5 ml Contains 1-2.5 ml of iron.
【０００８】[0008]
実験例１ マウス及びラットを用いて回転カゴ中で自由走行させな
がら一定期間霊芝エキスまたは水道水を自由摂取させて
おき、該期間経過後の１日当りの平均走行距離を表１に
示した。表１の走行距離を見ればわかるように、いずれ
の試験条件でも霊芝投与の方が、水道水を与えた対照区
よりも１日当りの平均走行距離は長くなった。さらに投
与期間が長い程一日あたりの平均走行距離は長くなって
いる。また同じ投与期間で霊芝エキス濃度が0.25％と0.
5 ％と異なる場合を比較すると、マウスの雄で見られる
ように0.5 ％群の方が多少走行距離が延びており、対照
区との比も更に大きくなっている。ラットとマウスの間
には大きな差は見られなかった。Experimental Example 1 Using a mouse and a rat, the rats were allowed to freely ingest a Reishi extract or tap water for a certain period of time while freely running in a rotating basket, and the average running distance per day after the passage of the period is shown in Table 1. As can be seen from the mileage shown in Table 1, the average mileage per day was longer in the Lishiba administration than in the control group fed with tap water under any of the test conditions. Furthermore, the longer the administration period, the longer the average mileage per day. In the same administration period, the reishi extract concentration was 0.25% and 0.1%.
Compared with the case of 5%, the mileage was slightly longer in the 0.5% group, as seen in the male mice, and the ratio in the control group was even larger. No significant difference was seen between rats and mice.
【０００９】[0009]
【表１】 [Table 1]
【００１０】実験例２ ラットを用いて１％霊芝エキスの投与方法が異なる場合
の回転カゴ中での走行距離の比較をした。結果を表２に
示す。自由摂取，胃内投与，腹腔内投与の順に走行距離
は大きくなり、対照区との比を見ても明らかに腹腔内投
与が一番良かった。いずれにしても霊芝投与区は対照区
の1.2 〜1.3 倍の走行距離があり、自由摂取でも充分な
効果があることがわかった。EXPERIMENTAL EXAMPLE 2 Using rats, a comparison was made of the distance traveled in a rotating car when the administration method of 1% reishi extract was different. Table 2 shows the results. The running distance increased in the order of free intake, intragastric administration, and intraperitoneal administration. Intraperitoneal administration was clearly the best in comparison with the control group. In any case, the Lingzhi administration group had a mileage 1.2 to 1.3 times that of the control group, and it was found that free intake had a sufficient effect.
【００１１】[0011]
【表２】 [Table 2]
【００１２】実験例３ マウスを用いて霊芝エキスを一週間腹腔内投与し、その
後一週間無投与とした後の回転カゴ中の走行テストの結
果を表３に示した。霊芝エキス濃度は１％とした。その
結果対照区に対して約1.4 倍の走行距離を示した。これ
は霊芝を摂取した後、しばらく摂取しなくても持久力は
維持できていることを示している。Experimental Example 3 Table 3 shows the results of a running test in a rotating basket after intraperitoneal administration of a Ganoderma lucidum extract using a mouse for one week and no administration for one week thereafter. Reishi extract concentration was 1%. As a result, the traveling distance was about 1.4 times that of the control plot. This indicates that endurance can be maintained after taking Lingzhi without even taking it for a while.
【００１３】[0013]
【表３】 [Table 3]
【００１４】実験例４ 0.25％霊芝エキスを８週間にわたりラットに投与しつつ
毎日トレッドミルでトレーニングさせた。しかる後、ベ
ルト上を疲労困憊となるまで４５ｍ／分の速度で走行さ
せた時の走行距離を表４に示した。雌雄共に対照区の水
道水を摂取群に比べ１５〜１６％長く走ることができ
た。Experimental Example 4 Rats were trained daily on a treadmill while administering 0.25% Reishi extract for 8 weeks. Thereafter, the running distance when the belt was run at a speed of 45 m / min until exhaustion was shown in Table 4. Both males and females ran 15-16% longer than the control group with tap water in the control group.
【００１５】[0015]
【表４】 [Table 4]
【００１６】以上の実験結果をまとめると霊芝エキスを
投与した群では、自由走行、強制走行のいずれの場合で
も走行距離が増大した。また経口自由摂取でも充分な効
力が現れていた。さらにまた霊芝エキス摂取後しばらく
摂取を中断しても走行距離の増加が見られた。従って霊
芝成分を含有する組成物は、長距離走行能力を増大させ
る作用を有するとの結論が得られる。To summarize the above experimental results, in the group to which Reishi extract was administered, the running distance was increased in both free running and forced running. Sufficient efficacy was shown even with oral free intake. Furthermore, even if the ingestion was interrupted for a while after the ingestion of the reishi extract, the mileage increased. Therefore, it can be concluded that the composition containing the Reishi component has an effect of increasing long-distance running ability.
【００１７】本発明の霊芝含有組成物は以上の様に筋肉
の疲労の起こり方を軽減して有酸素運動等においてその
持久力を増大させる効力を有する。As described above, the reishi-containing composition of the present invention has the effect of reducing the occurrence of muscle fatigue and increasing the endurance in aerobic exercise and the like.
───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 平２−219547（ＪＰ，Ａ) 特開 平３−98546（ＪＰ，Ａ) 近畿大学薬学部久保道徳編「漢方薬医 学双書 別巻１ 霊芝」1985年11月15日 （株）三一書房発行 第58〜59頁 ────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-2-219547 (JP, A) JP-A-3-98546 (JP, A) Kinki University, Faculty of Pharmaceutical Sciences, Ed. November 15, 1985 Published by Sanichi Shobo Co., Ltd., pp. 58-59
Claims (1)
における走行距離増大作用を示すものであることを特徴
とする長距離走能力改善用組成物。1. A composition for improving long-distance running ability, comprising a hot water extract of Ganoderma lucidum and exhibiting the effect of increasing the running distance in long-distance running.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31411491A JP3282840B2 (en) | 1991-10-30 | 1991-10-30 | Composition for improving long-distance running ability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31411491A JP3282840B2 (en) | 1991-10-30 | 1991-10-30 | Composition for improving long-distance running ability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05123135A JPH05123135A (en) | 1993-05-21 |
| JP3282840B2 true JP3282840B2 (en) | 2002-05-20 |
Family
ID=18049417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP31411491A Expired - Lifetime JP3282840B2 (en) | 1991-10-30 | 1991-10-30 | Composition for improving long-distance running ability |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3282840B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070054965A1 (en) | 2005-09-05 | 2007-03-08 | Kao Corporation | AMPK activating agent |
| CN101296693B (en) | 2005-10-26 | 2012-07-04 | 花王株式会社 | Endurance improver |
| WO2012034534A1 (en) * | 2010-09-17 | 2012-03-22 | 江中药业股份有限公司 | Use of the traditional chinese medicine composition for manufacturing a health food or medicament for preventing and alleviating physical fatigue |
| JP7253764B2 (en) * | 2018-07-12 | 2023-04-07 | 日本メナード化粧品株式会社 | athletic performance enhancer |
-
1991
- 1991-10-30 JP JP31411491A patent/JP3282840B2/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 近畿大学薬学部久保道徳編「漢方薬医学双書 別巻１ 霊芝」１９８５年１１月１５日（株）三一書房発行 第５８〜５９頁 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05123135A (en) | 1993-05-21 |
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