JP3240345B2 - Oral hypnotics, hypnotic foods and drinks - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to an oral insomnia promoting agent and
The present invention relates to foods for promoting sleep and falling asleep . More specifically, the present invention is characterized by containing sandalwood essential oil as an active ingredient, and has the effect of promoting sleep and deep sleep for humans and animals who cannot obtain normal sleep due to stress or mental irritability. The present invention relates to an oral sleep promoting agent and food and drink.

[0002]

2. Description of the Related Art In recent years, the development of industry and the accompanying changes in the living environment have resulted in physical and psychological stimuli, that is, a lot of stress on animals, including humans and pets, as the term "stress society." ing. As society becomes more complicated, more and more humans have complained of insomnia, such as difficulty falling asleep or not being able to sleep, even though specific lesions such as organic lesions are not found. Is thought to be due to stress.

[0003] When this symptom is severe, that is, as a remedy for insomnia that requires hospital visits, sleep-inducing drugs such as tranquilizers are used. However, these drugs are dramatic and have many drawbacks in that they have many side effects. is there.

[0004] On the other hand, in aromatherapy which has been known for a long time mainly in the European region, a method of eliminating insomnia by various scents of essential oils has been widely reported ("practical aromatherapy": by Charli Price, Takayama Translated by Taro Hayashi, 1987
("Aromatherapy" by Robert Tisland, translated by Rintaro Takayama, 1985).
There have been many reports on the effects of scents on physiological and psychological states. For example, Koga reports on the effects of aromatherapy in terms of brain function (Chemical Technology, 1990
August) (Fragrance Journal, No.86, 1987)
) And a report on the relationship between scents and consciousness by torii gates (Fragrance Journal, No. 77, 16, 1986). It has also been reported that the fragrances of bitter orange essential oil, basil oil, jasmine oil and the like have a sleep-inducing or sleep-promoting effect (JP-A-4-128234, JP-A-4-128234).
149136).

[0005] However, the sedation and sleep-inducing effects of these conventional fragrance therapies are caused by the odor of each essential oil stimulating the olfaction of humans and animals, and the scent of the fragrance is smelled from the nose. Limited to how they are used. This is because it has been conventionally thought that a specific transmission pathway of the brain olfactory pathway is involved in the mechanism of action of the fragrance such as anti-stress and antidepression.

[0006] The limbic system is an organ responsible for controlling instinct, joy, sadness, anger, surprise and the like, and autonomic nervous function. While closely communicating with the hypothalamus, the emotion and related physical reactions are involved. Is deeply involved in The secondary nervous system of the olfactory tract emanating from the mitral cells of the olfactory bulb is directly input to the limbic system, and the stimulus (scent) received by the olfactory sense is related to the control of emotions and autonomic nervous functions. [Stress and aromatherapy, Yoshihiko Koga (Fragrance Journal, No.86, 1
987), Trial of treatment of depression by fragrance-Scientific verification and clinical application, Komori, Fujiwara et al. (Japanese Journal of Neuropsychopharmacology, Vo)
l. 15, 39-42, 1995)].

On the other hand, sensitivity to fragrance and "like
It is also true that there is a clear individual difference in tastes such as “dislike”. When you smell the smell you like, you can get emotional effects such as ease of mood, relief, concentration, etc. On the other hand, smelling the smell you hate may be frustrating or uncomfortable. In addition, it has been reported that emotional and psychological factors based on tastes are greatly related to changes in electroencephalograms centered on α-waves, autonomic nervous functions, etc. [Scent and clinical application of psychiatry and its problems-neuropsychiatry] Physiological studies, Takami Yagyu (FOOD & FOOD INGREDIENTS JOUR
NAL No.156, 1993), EEG topography, Norio Torii (Fragrance Journal, 15-19, 1992-10)].

Accordingly, a hypnotic effect can be stably expected without being affected by individual sensitivity or taste, etc., and unlike a tranquilizer used conventionally as a sleeping pill, a safe sleep-promoting agent having no side effects, The development of agents is desired.

[0009]

SUMMARY OF THE INVENTION An object of the present invention is to provide an oral sleep-inducing agent which contains sandalwood essential oil as an active ingredient and is used orally.

[0010] Another object of the present invention is to provide a food product for promoting sleep onset, characterized by containing sandalwood essential oil.

[0011]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above-mentioned conventional problems. Unexpectedly, a specific essential oil such as sandalwood essential oil has been used for the conventional olfactory and oral mucosa. It has been found that an excellent hypnotic effect is exhibited by absorption into the body through the gastrointestinal tract by oral ingestion rather than absorption from the lungs.

Although sandalwood essential oil is used for anxiety and antidepressant in the field of aromatherapy (aromatic therapy), it has been reported that its fragrance component can hardly be expected to have a good sleep promoting effect ( JP-A-4-14913
No. 6). Also, because of the aromatic nature of the incense, there is a strong individual difference between likes and dislikes.

[0013] Under these facts, the above findings by the present inventors were just surprising. The present invention has been developed based on this finding.

[0014] That is, the present invention is an oral sleep-inducing agent characterized by containing sandalwood essential oil as an active ingredient.

[0015] The present invention is also a food and drink for promoting sleep onset, characterized by containing sandalwood essential oil.

[0016]

[0017]

Oral sleep onset promoter oral sleep onset promoter present invention DETAILED DESCRIPTION OF THE INVENTION, and characterized by a one containing sandalwood essential oil as an active ingredient, it is intended to achieve the hypnotic effect used orally I do.

The sandalwood essential oil used in the present invention includes, for example, Santant from East India belonging to the sandalwood family.
alum album, Eucar from Australia
uya spicata (or Santalum s)
picatum), Santalum lanceol
atum, Eremophila mitchelli
Or East African Osyris tenuifol
ia and the like, and essential oils that can be obtained by chopping the roots and steam distillation, or equivalents thereof,
Usually, sesquiterpene alcohols containing α-sandalol and β-sandalol as main components are contained. Further, the origin and place of production are not particularly limited, and those of various places of production such as Timor, Celebes, Malay Archipelago and the like can be used.

The oral sleep abstinence enhancer of the present invention may be any one containing such sandalwood essential oil as an active ingredient.
The purity of the essential oil contained is not particularly limited.

As shown in the experimental examples described later, sleep onset of the present invention
Sandalwood essential oil, which is an active ingredient of the accelerator , exerts a significant hypnotic effect even when encapsulated in a capsule so as not to leak the fragrance of sandalwood essential oil and administered to a subject. That is, sandalwood essential oil, which is an active ingredient of the oral sleep-inducing agent of the present invention, is absorbed from the digestive tract such as the stomach and the small intestine, and exhibits a hypnotic effect. Therefore, the sleep attenuating agent of the present invention is prepared in a form in which sandalwood essential oil is absorbed from the gastrointestinal tract such as the stomach and the small intestine, that is, as a gastrointestinal absorption component, and is orally ingested. It is necessary.

The aroma component of sandalwood essential oil has a wide range of likes and dislikes, and some people may rather feel mental stress such as disgust. From this point of view, the oral sleep onset promoting agent of the present invention is very useful hypnotic agent in that it can expect stable hypnotic effect without being affected by the palatability of human.

The form of the sleep-inducing agent of the present invention is not particularly limited as long as it can be taken orally. Specifically, tablets, pills, granules, powders, capsules, microcapsules, and suspensions A turbid liquid, a liquid, a syrup, a jelly, and the like are exemplified, and can be appropriately selected depending on a use purpose, a use target, and the like. Preferably, capsules, microcapsules,
Granules, liquids, syrups and jellies.

The composition and preparation method of the sleep onset promoting agent of the present invention are not particularly limited as described above, and can be appropriately prepared according to the purpose. For example, with respect to the composition of the sleep onset promoting agent of the present invention, sandalwood essential oil itself may be used, or other excipients, disintegrants, binders, lubricants, flavoring agents, flavoring agents, sweeteners, stabilizers. And various oral additives that are pharmaceutically or food-sanitary acceptable such as vitamins and preservatives.

The oral sleep abstinence enhancer of the present invention contains a plant extract as an active ingredient and has a stimulating action at the beginning of administration and a stimulus to the stomach, as compared with conventional hypnotics such as barbituric acid and chloral hydrate. It has no side effects such as post-effects on the following day, has a mild effect, has a wide safe range, and has low tolerance and habit.

Therefore, it can be widely used not only as pharmaceuticals but also as pharmaceutical auxiliaries, food additives, food auxiliaries, feed and feed additives, and the like. That is, the oral sleep onset promoter of the present invention, sleep onset promoting agents, sleep onset promoting adjuvants, sleep onset promoting food additive, sleep onset promoting food supplements, ON
It widely covers sleep-promoting feeds and feed additives.

The content of the sandalwood essential oil of the oral sleep promoting agent of the present invention is not particularly limited, but is usually 0.0001 to 100 (w / w) in consideration of the dose per one dose described below.
w) It is appropriately selected from the range of%.

[0027] Oral sleep onset promoting agent of the present invention to the sleep onset accelerator <br/> agent itself may be administered to a human or animal, also pharmaceuticals, also be used by admixing the food or feed, etc. it can.

The amount of sandalwood essential oil contained in the sleep-inducing agent of the present invention is not fixed depending on the condition of the subject to which it is applied or on its dosage form, but is about 3 to 15,000 mg per oral unit per dosage unit. It is desirable that The sleep onset promoting agent of the present invention is usually used once or twice a day.
It is preferably taken 1 to 30 minutes before bedtime. The dose of the sleep onset promoting agent of the present invention at one time varies depending on the application target, the age, sex, symptoms, etc. of the human or animal, but it is usually 0.1 to 640 mg / kg body weight, preferably as sandalwood essential oil, preferably, 5-320
mg / kg body weight, more preferably 45-160 mg / k
It can be appropriately selected from the range of g weight.

[0029] The oral sleep-promoting agent of the present invention can be widely applied to sleep disorders, but especially for mental causes such as stress, anxiety, overwork, depression, and insomnia in a state of excitement. It is valid. In addition, the sleep onset promoting agent of the present invention has an effect of inducing physiological sleep (sleep inducing action) and an effect of continuously prolonging sleep time (continuous hypnotic action) .

The oral sleep abstinence promoting agent of the present invention can be used not only for humans,
It can be widely applied to warm-blooded animals. In particular, in recent years, stress in pets such as cats, dogs, rats, hamsters, and birds kept indoors has become a problem, and it can be effectively used to improve stress insomnia in such pets. In this case, the oral sleep onset promoting agent of the present invention may be administered directly as capsules and syrups, sleep onset promoting agent of the present invention may be administered to the pet in admixture with water or food, or the like.

Food and drink for promoting sleep onset As shown in the experimental examples described below, the hypnotic effect of sandalwood essential oil is exerted by its gastrointestinal absorption, and compared with hypnotics conventionally used as pharmaceuticals. It is safe with little adverse effects such as side effects and habits, and has a mild action and can be used on a daily basis. Therefore, by adding sandalwood essential oil to foods and drinks, it is possible to prepare foods and drinks for promoting sleep onset having a hypnotic effect.

The act of eating is one way to relieve mental stress, and everyone experiences that they cannot sleep or wake up due to hunger.

From this point of view, the present invention provides the effect of "eating" to alleviate mental stress and satisfy the feeling of hunger, and to promote sleep onset which has a hypnotic effect by absorbing sandalwood essential oil itself from the digestive tract. there is provided a use drink <br/> food.

That is, the present invention provides a food / drink for promoting sleep onset characterized by containing essential oil of sandalwood.

The essential oils of sandalwood include those described above.

The food and drink of the present invention may be in any form as long as sandalwood essential oil is absorbed from the digestive tract, that is, formulated and prepared as a gastrointestinal absorption component. Is not particularly limited.

For example, the types of foods and drinks targeted by the present invention are not particularly limited as long as the hypnotic effect of sandalwood essential oil is not impaired, and cookies, biscuits, jellies,
Sweets such as candy and marshmallows, foods such as yogurt and noodles, refreshing and carbonated drinks, milk, cocoa, tea, coffee,
A wide range of beverages or luxury items such as alcohols can be targeted.

Preferably, it is a diet food or drink.
Here, food and drink for diet refers to food and drink in consideration of nutrition and calories for weight control, specifically, the calorie per meal is usually 0 to 100 kcal, preferably 0 to 40 kcal, more preferably Is 0-3
It is in the kilocalorie range, and more specifically, cookies, biscuits, jellies, marshmallows, soft drinks or cocoa, etc. in this calorie range.

The diet and drink for promoting sleep onset of the present invention can be eaten without fear of obesity or guilt when obstruction is caused by mental depression or hunger caused by the diet. It is useful in that it can also exert a stress relieving effect by eating.

Further, according to the food and drink of the present invention, unlike drugs, even elderly people who suffer from insomnia (mild sleep disorder) can take it without resistance due to the decrease in sleep time with aging.

The method for preparing the food and drink of the present invention is not limited either, and confectioneries such as cookies and soft drinks may be prepared by blending sandalwood essential oil into a commonly used food or beverage composition. and, also milk, sandalwood essential oil itself or the above-mentioned oral entering the ready-made food, such as alcohols
It may be prepared by adding and blending a sleep promoting agent as a food additive or the like.

[0042] is a hypnotic component of sleep onset promoting food of the present invention sandalwood essential oil is absorbed from the gastrointestinal tract is intended that gradually achieve the effect, sleep onset promoting food of the present invention, prior to normal sleeping Preferably, it is taken 2 hours to 30 minutes before.

The form of essential oil contained in sandalwood is not particularly limited as long as it is absorbed in the digestive tract.
It can be appropriately selected depending on the type of food and drink. For example, the essential oil may be used as it is, or may be prepared in various forms such as powder, granule, microcapsule, and syrup. However, when the food and drink contain more than 0.5% by weight of sandalwood essential oil, the smell and taste of the essential oil are sealed so as to reduce the unpleasant odor and taste of sandalwood essential oil and not impair the taste of the food and drink itself. The form
Preferably, it is desirable to include them in the form of microcapsules.

As long as the essential oil of sandalwood is absorbed from the digestive tract, the aromaticity of the food and drink is not particularly limited, and it depends on the type of food and drink, its flavor and taste, and the taste of the subject. Can be selected as appropriate. Therefore, the food and drink of the present invention may or may not have an aroma derived from sandalwood essential oil.

The amount of sandalwood essential oil contained in the food for promoting sleep onset of the present invention varies depending on the type of food and the like.
Usually 0.005 to 20% by weight, preferably 0.01 to 1%
It is 2% by weight, more preferably 0.1 to 5% by weight.

The amount of intake varies depending on the age, sex, insomnia symptoms, etc. of the food and drink, but is usually 0.1 to 40 mg / kg body weight per serving as essential oil, preferably 1 to 2 mg / kg.
The range is 0 mg / kg.

Sleep-promoting feed The above-mentioned sandalwood essential oil can be applied to animal feed, expecting a hypnotic effect by oral administration.

That is, the present invention provides a sleep-promoting diet containing sandalwood essential oil.

The term "feed" generally refers to foods and drinks for growing and breeding animals, but the present invention is not limited to such purposes and broadly includes foods and drinks to be given to animals. Used for the purpose.

Also, the animal to which the diet of the present invention is directed is
It is not limited by the type of animal, but includes all warm-blooded animals, that is, birds and mammals, and specifically includes pets and livestock such as dogs, cats, monkeys, birds, rats, and hamsters. .

The feed of the present invention may be in a form in which sandalwood essential oil is absorbed from the gastrointestinal tract, in other words, as long as it contains a gastrointestinal absorption component.
The preparation method and the like are not particularly limited.

In general, it can be prepared by appropriately mixing with a commonly used feed / feed or feed / feed composition (regardless of whether it is a natural feed / feed or an artificial feed / feed). The content of sandalwood essential oil varies depending on the type, age, body weight, etc. of the animal, and can be appropriately selected and changed. Usually 40-65 as an essential oil per meal
The essential oil is selected in the range of 0.5 to 30% by weight, preferably 1 to 20% by weight per meal, so that 0 mg / kg, preferably 160 to 300 mg / kg is ingested.

Examples of the present invention and reference examples will be shown below.
These examples are merely for illustrating the present invention, and the present invention is not limited thereto.

[0054]

EXAMPLES Example 1 (Capsule) 5 g of gelatin heated to 40 to 60 ° C. is gradually added with stirring, and mixed and dissolved. After defoaming the mixed solution under reduced pressure, appropriate amounts of titanium oxide and a dye are added and further mixed. Then, after filling into a capsule type bottle and molding, the water content is reduced to 15
１８18% dried, filled with 200 mg of sandalwood essential oil in the body of the capsule, combined with the cap,
A capsule containing 200 mg of sandalwood essential oil was prepared.

Example 2 (microcapsules) 5 g of gelatin was added to 100 g of purified water heated to 40 ° C.
Is added slowly with stirring, and mixed and dissolved. afterwards,
Sandalwood essential oil 200mg, titanium oxide, glycerin,
An appropriate amount of dye is added and mixed to obtain a capsule. Thereafter, the capsule was cooled and dehydrated until the water content became 15 to 18%, and further dried until the water content became 8.2 to 16%. Thereafter, filtration was performed to prepare microcapsules containing sandalwood essential oil.

[0056]Example 3 (cookie) Contains sandalwood essential oil by the following method using the following amount
Cookies were prepared.  Soft flour 200g Unsalted butter 70g Sugar (granulated sugar) 80g 1 eggSandalwood essential oil 2 g First, stir the butter, then slowly add the sugar while stirring
Was added. After adding the cracked egg into this,
Dan essential oil was added, and the mixture was further stirred at a reduced speed. sufficient
When mixed, add the evenly sifted flour to this
After stirring at low speed, combine them into one. This is about 3
After lying in a low-temperature room for 0 minutes, spread it evenly with a thickness of about 1 cm.
Then, pull out with a 5 cm diameter circular mold. Next,
Arrange the key dough on the top plate and use a dough table to prevent evaporation of essential oils.
Apply olive oil on the surface and in an oven preheated at 170 ° C
Heat for 12-15 minutes and cook with sandalwood essential oil.
The key was prepared.

Example 4 (Soft drink) Soft drink was prepared according to the following formulation.

Fructose-glucose liquid sugar 6.0 parts by weight Sodium citrate 0.6 L-ascorbic acid 3.0 Sandalwood essential oil 0.5 water Suitable amount total amount 100 parts by weight Example 5 (tea) Black tea leaves 1.2 mg Is put in 100 ml of hot water (80 ° C.), sufficiently immersed, and then decanted to obtain a leachate. 5 g of sugar and 0.5 of sandalwood essential oil were added to this leachate.
g was added to make a total of 100 ml.

Example 6 (Jelly) After heating 50 ml of water to about 60 ° C., gelatin was added and stirred. After the gelatin was dissolved, the other ingredients were added with stirring, and after everything was dissolved, the mixture was poured into a container, cooled and solidified in a low-temperature room, and a jelly containing 0.5% by weight of sandalwood essential oil was prepared.

Sugar 22.0 parts by weight L-tartaric acid 0.1 sodium citrate 0.1 gelatin 1.1 citric acid 0.1 sandalwood essential oil 0.5 water suitable amount total amount 100 parts by weight Example 7 (alcohols) Neutral spirits 30.0 parts by weight Stepiosite 0.1 Fragrance 5.0 Sandalwood essential oil 0.3 Water Suitable amount total amount 100 parts by weight Example 8 (pet food) Sandalwood essential oil 60 weight by the same method as Example 2 % Microcapsules were prepared. Next, the microcapsules were blended at the following ratio to prepare a feed (pet food) containing 5.4% by weight of sandalwood essential oil.

[0061] Beef (20 × 20 × 20 mm soybean shaped cut) 80.0 parts by weight of coagulant (carrageenan) 2.0 saline 0.1 sandalwood essential oil-filled microcapsules 9.0 water appropriate amount Total 100.0 parts by weight

[0062]

[Experimental Examples] Experimental Example 1: Barbital sleep prolongation test -Experimental example A-As test essential oils, sandalwood, Marjorum, chamomile, rose (Ros)
e), Clary Sage, Velbena,
And dynyl acetate (Lynaryl Acetate) (each manufactured by Nagaoka Aroma Co., Ltd.) were orally administered to male ddy mice at a dose of 600 mg / kg each, and the sleep prolonging effect of these essential oils was compared.

The ddy male mouse animal (Japan SLC) used had a temperature of 21 to 25 ° C and a humidity of 48 to
Solid sample F-2 (Funabashi Farm) in a breeding room set under the conditions of 65%, lighting time 12 hours (7:00 to 19:00)
And tap water (conforming to tap water quality standards) was freely taken and bred. The mice were housed only with no abnormalities by observing their health condition with the naked eye, and preliminarily reared for 3 days or more from the time of arrival, and then used in more general condition.

The experiment was conducted at the age of 6 weeks (weight 27-32).
The mice in g) were used as 10 mice per group.

The experiment was conducted using a solvent (olive oil: control).
Alternatively, 30 minutes after oral administration of a test solution (test essential oil such as sandalwood essential oil), 45 mg / kg of pentobarbital (Nembutal: manufactured by Dainippon Pharmaceutical) was intraperitoneally administered, and before returning spontaneously from the lateral posture to the abdominal position. The time was measured as the anesthesia time.

Table 1 shows the results.

[0067]

[Table 1]

When the hypnotic effects of the essential oils were compared, a remarkable sleep-prolonging effect was observed in sandalwood essential oil, and there was almost no difference in effect due to individual differences. On the other hand, marjoram, chamomile, rose, and clary sage showed large individual differences, some of which exhibited prolonging action and those of which did not, so that the sleep prolonging action of essential oil could not be confirmed.

-Experimental Example B- Of the essential oils used in Experimental Example A, sandalwood essential oil having a remarkable hypnotic effect was 2.5 to 640 mg / k.
The same experiment as in Experimental Example A was performed except that the dose was changed within the range of g body weight.

Table 2 shows the results.

[0071]

[Table 2]

The sleep prolonging effect was remarkably recognized from the administration of sandalwood essential oil at a dose of 40 mg / kg or more.

EXPERIMENTAL EXAMPLE 2 Using the same system as in Experimental Example 1, the mice were treated with a test solution (sandalwood essential oil, 2.5 m / kg body weight).
g, 10 mg, 40 mg, 160 mg, and 640 mg) or as a control, 30 minutes after oral administration of a solvent (olive oil), and 45 mg / kg of pentobarbital (Nembutal: manufactured by Dainippon Pharmaceutical) intraperitoneally, followed by righting reflex. The time until disappearance was measured and evaluated as sleep onset time.

FIG. 1 shows the results.

From this experiment, it was confirmed that the administration of sandalwood essential oil significantly reduced the bedtime.

Experimental Example 3 Three adults were randomly selected from adults who were uncomfortable with falling asleep or complaining of insomnia, and these were used as subjects to take capsules containing the essential oil of sandalwood prepared with the following formulation and sleep. The effect on was examined.

The hypnotic effect was evaluated on the following evaluation items on a scale of 1 to 5 in comparison with the state before the experiment.

Evaluation items: (i) falling asleep, (ii) depth of sleep, (iii) awakening during sleep, (i)
v) Awake state ・ Evaluation: Compared to usual A: Good, B: Somewhat good, C: No change, D: Somewhat bad, E: Bad In addition, taking time is 30 minutes to 1 before bedtime They were instructed to avoid taking alcohol and other psychiatric drugs when taking the drug.

Capsules: An oral preparation containing essential oil of sandalwood was prepared by enclosing 200 mg of sandalwood essential oil in a hard capsule without leaking aroma.

Table 3 shows the results.

[0081]

[Table 3 ] Evaluation ABCDE (i) Sleeping 300 000 (number of people) (ii) Depth of sleep 300 000 (iii) Awakening during sleep 300 000 (iv) Awake state 2100 As is clear from Table 3, the hypnotic effect of the sandalwood essential oil-containing agent was observed for all of the subjects. One of the three patients took sandalwood essential oil three times every two days to check the state of sleep. As a result, all items were evaluated as A.

At the same time, a questionnaire was taken as to whether the following symptoms did not appear when the subject took it or on the following day.

Palpitations / vertigo / rash /
Fatigue / Headache / Nausea / Vomiting /
Diarrhea / Mouth thirst / The next day, I felt drowsy during the day /
The next day, fatigue remained.

As a result, none of the subjects corresponded to any of the items.

From this, it can be said that the sleep onset promoting agent of the present invention not only has a hypnotic effect (promoting sleep onset, maintaining hypnosis, and sleeping well) but is also safe without any side effects including post-action.

As a comparative experiment, capsules containing orange essential oil (20 capsules) were prepared in the same manner as in the administration of sandalwood essential oil.
0 mg / capsule) and prepare it for 30 minutes before bedtime.
The effect on sleep was examined by having the patient take the drug at time.
As a result, with respect to the state of falling asleep, the depth of sleep, and the state of awakening, the result was “no change” from before the experiment, and the result of waking up during sleep was “worse” than usual.

[Brief description of the drawings]

FIG. 1 is a view showing the results obtained by examining the sleep-inducing effect of sandalwood essential oil performed in Experimental Example 2.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification code FI A23L 1/307 A23L 1/307 2/00 A61K 9/48 A61K 9/48 A61P 25/20 A61P 25/20 C11B 9/00 A C11B 9/00 A23L 2/00 Z (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 35/78 A23G 3/00 A23L 1/30 A23L 2/00 A61K 9/48 C11B 9/00 BIOSIS (DIALOG) CA (STN)

Claims (6)

(57) [Claims] 1. An oral sleep abstinence promoting agent comprising sandalwood essential oil as an active ingredient. 2. The essential oil of sandalwood is used in an amount of 0.1 to 0.1 mg per administration.
The oral hypnotic agent according to claim 1, which is contained in a range of 640 mg / kg body weight. 3. A food or drink for promoting sleep onset, comprising essential oil of sandalwood. 4. The essential oil of sandalwood is 0.005 to 20% by weight.
The food / drink for promoting sleep onset according to claim 3, which is contained in the range of: 5. The food or drink for promoting sleep onset according to claim 3 or 4, wherein the food or drink is a food or drink for diet. 6. The food for promoting sleep onset according to any one of claims 3 to 5, wherein the food or drink is selected from cookies, biscuits, jellies, marshmallows, soft drinks and cocoa.