JP3063781B2 - Crystallized glass porous implant material - Google Patents
Crystallized glass porous implant materialInfo
- Publication number
- JP3063781B2 JP3063781B2 JP3024011A JP2401191A JP3063781B2 JP 3063781 B2 JP3063781 B2 JP 3063781B2 JP 3024011 A JP3024011 A JP 3024011A JP 2401191 A JP2401191 A JP 2401191A JP 3063781 B2 JP3063781 B2 JP 3063781B2
- Authority
- JP
- Japan
- Prior art keywords
- crystallized glass
- bone
- implant material
- porous
- promoting substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000011521 glass Substances 0.000 title claims description 32
- 239000000463 material Substances 0.000 title claims description 13
- 239000007943 implant Substances 0.000 title claims description 11
- 230000011164 ossification Effects 0.000 claims description 17
- 230000001737 promoting effect Effects 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 16
- 239000011148 porous material Substances 0.000 claims description 9
- 229910052586 apatite Inorganic materials 0.000 claims description 7
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 7
- NWXHSRDXUJENGJ-UHFFFAOYSA-N calcium;magnesium;dioxido(oxo)silane Chemical compound [Mg+2].[Ca+2].[O-][Si]([O-])=O.[O-][Si]([O-])=O NWXHSRDXUJENGJ-UHFFFAOYSA-N 0.000 claims description 6
- 229910052637 diopside Inorganic materials 0.000 claims description 6
- 229910052882 wollastonite Inorganic materials 0.000 claims description 6
- 239000010456 wollastonite Substances 0.000 claims description 6
- 210000000988 bone and bone Anatomy 0.000 description 26
- 239000000843 powder Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 230000004071 biological effect Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 229910004298 SiO 2 Inorganic materials 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000010304 firing Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000002188 osteogenic effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000003275 diaphysis Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C10/00—Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/062—Glass compositions containing silica with less than 40% silica by weight
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Geochemistry & Mineralogy (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Ceramic Engineering (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Glass Compositions (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、骨欠損部の補填等に使
用される結晶化ガラス製多孔質インプラント材に関する
ものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a porous implant made of crystallized glass used for filling a bone defect or the like.
【０００２】[0002]
【従来の技術】従来、欠損した骨の補填には、患者本人
の正常部位から採取した海綿状の自家骨、いわゆる海綿
骨が用いられていたが、この方法では、損傷箇所以外の
骨組織を切除するため患者の苦痛が大きいこと、またそ
の手術を行うにあたって多大な労力を要すること、自家
骨の採取量に限界があること等の問題を有している。2. Description of the Related Art Conventionally, spongy autogenous bones, or so-called trabecular bones, collected from a patient's normal site have been used to replace the missing bones. There are problems such as that the resection is painful for the patient, that the operation requires a great deal of labor, and that the amount of autologous bone collected is limited.
【０００３】このような事情から、自家骨の代替物とし
て種々の人工骨の使用が試みられている。特に、アパタ
イト、ウオラストナイト、ジオプサイド等の結晶を析出
するＳｉＯ2 −ＣａＯ−ＭｇＯ−Ｐ2 Ｏ5 系結晶化ガラ
スは、高い機械的強度を有し、しかも生体活性に優れて
いるため、人工骨材料として注目されている。[0003] Under such circumstances, use of various artificial bones as substitutes for autologous bones has been attempted. In particular, SiO 2 —CaO—MgO—P 2 O 5 -based crystallized glass that precipitates crystals such as apatite, wollastonite, and diopside has high mechanical strength and is excellent in bioactivity. It is attracting attention as a bone material.
【０００４】ところで近年、動物の骨由来の骨形成促進
物質を骨修復に使用することが提案されており、ＳｉＯ
2 −ＣａＯ−ＭｇＯ−Ｐ2 Ｏ5 系結晶化ガラス製の人工
骨に骨形成促進物質を付着又は含有させた骨修復材が特
開平２−２４９５５６号において開示されている。Recently, it has been proposed to use an osteogenesis-promoting substance derived from animal bone for bone repair.
2 -CaO-MgO-P 2 O 5 based crystallized glass bone repair material obtained by attaching or contain osteogenesis promoting substance to the artificial bone is disclosed in JP-A-2-249556.
【０００５】[0005]
【発明が解決しようとする課題】一般に、生体活性を有
する結晶化ガラスは、体液と接触することによってＣａ
2+イオンを溶出し、体液中のＨＰＯ4 2- イオンとともに
生体類似のアパタイト層をその外表面に形成するため、
生体骨と容易に結合する。Generally, crystallized glass having bioactivity is converted into Ca by contact with body fluid.
To elute 2+ ions and form a bio-like apatite layer on the outer surface together with HPO 4 2- ions in body fluids,
Combines easily with living bone.
【０００６】しかしながら、上記特開平２−２４９５５
６号に開示の骨修復材は、骨形成促進物質の付着によっ
て結晶化ガラスと体液の接触面積が小さくなるため、結
晶化ガラスからＣａ2+イオンが溶出しにくくなり、生体
活性が低下するおそれがある。またその一方で骨形成促
進物質がすぐに生体中に溶け出してしまい、十分な骨形
成促進効果を得ることが困難である。[0006] However, Japanese Patent Application Laid-Open No. 2-24955 discloses the above.
In the bone repair material disclosed in No. 6, since the contact area between the crystallized glass and the body fluid is reduced due to the attachment of the bone formation promoting substance, Ca 2+ ions are hardly eluted from the crystallized glass, and the biological activity may be reduced. There is. On the other hand, the bone formation promoting substance immediately dissolves into the living body, and it is difficult to obtain a sufficient bone formation promotion effect.
【０００７】本発明の目的は、十分な骨形成促進効果が
得られるために、早期に生体骨と結合、一体化するイン
プラント材を提供することである。[0007] An object of the present invention is to provide an implant material that can be combined and integrated with living bone at an early stage in order to obtain a sufficient bone formation promoting effect.
【０００８】[0008]
【課題を解決するための手段】本発明者等は、種々の研
究を行った結果、生体活性を有する結晶化ガラスの多孔
体を使用することにより、上記目的が達成できることを
見いだし、本発明として提案するものである。As a result of various studies, the present inventors have found that the above object can be achieved by using a porous body of crystallized glass having bioactivity. It is a suggestion.
【０００９】即ち、本発明の結晶化ガラス製多孔質イン
プラント材は、アパタイト、ウオラストナイト、及びジ
オプサイドの少なくとも１種を析出した三次元網状構造
を有する結晶化ガラス多孔体に、骨形成促進物質を付着
又は含浸させてなることを特徴とする。That is, the crystalline implanted porous implant material of the present invention has a three-dimensional network structure in which at least one of apatite, wollastonite and diopside is precipitated.
Characterized in that an osteogenesis promoting substance is attached or impregnated to a crystallized glass porous body having the following.
【００１０】[0010]
【作用】本発明の結晶化ガラス製多孔質インプラント材
は、表面積が非常に大きい多孔体を使用するために、骨
形成促進物質を付着させても結晶化ガラスの生体活性が
ほとんど低下しない。また、骨形成促進物質を多量に付
着、含浸させることができる。しかも骨形成促進物質が
多孔体の気孔内部に付着するため、短時間に生体中に溶
け出すことがない。さらに多孔体が三次元網状構造を有
しているため、新生骨が増生、侵入しやすいという特徴
がある。 The crystallized glass porous implant material of the present invention uses a porous material having a very large surface area, so that the biological activity of the crystallized glass hardly decreases even if an osteogenesis promoting substance is attached. In addition, a large amount of the bone formation promoting substance can be attached and impregnated. Moreover, since the bone formation promoting substance adheres to the inside of the pores of the porous body, it does not dissolve into the living body in a short time. Furthermore, the porous body has a three-dimensional network structure.
Feature that new bone grows easily and invades easily
There is.
【００１１】本発明において使用する結晶化ガラス多孔
体は、アパタイト、ウオラストナイト、及びジオプサイ
ドの少なくとも１種を析出し、生体活性を有するもので
ある。このような結晶化ガラスとしては、種々の組成を
有するものを使用することが可能であるが、特に、重量
百分率でＳｉＯ2 ２２〜５０％、Ｐ2 Ｏ5 ８〜３０％、
ＣａＯ ２０〜５３％、ＭｇＯ １〜１６％、Ｆ2 ０．
１〜２％、Ａｌ2 Ｏ3 ０〜９％、Ｂ2 Ｏ3 ０〜５％の組
成を有する結晶化ガラスを使用することが好ましい。The crystallized porous glass used in the present invention has at least one of apatite, wollastonite and diopside, and has biological activity. As such crystallized glass, those having various compositions can be used. In particular, SiO 2 22 to 50%, P 2 O 5 8 to 30% by weight percentage,
CaO 20-53%, MgO 1-16%, F 2 0.
1~2%, Al 2 O 3 0~9 %, it is preferable to use a crystallized glass having a composition of B 2 O 3 0~5%.
【００１２】また結晶化ガラス多孔体は、平均孔径が２
０〜２０００μｍ、気孔率が６６〜９５％であることが
好ましい。即ち、平均孔径が２０μｍより小さいと新生
骨が侵入できず、２０００μｍより大きいと十分な機械
的強度が得られない。気孔率が６６％より少ないと独立
気孔を含みやすくなり、体液に接する面積が小さくな
る。このため骨形成促進物質を付着させると生体活性が
著しく低下する。また十分な量の骨形成促進物質を付
着、含浸させることができなくなる。一方気孔率が９５
％より大きいと多孔体の骨格構造が崩れやすくなり、十
分な機械的強度が得られない。なお、三次元網状構造を
有する結晶化ガラス多孔体を作製するには、まず結晶性
ガラス粉末を水、バインダー（例えばポリビニルアルコ
ール）と混合してスラリーにし、次いでスラリーを三次
元網状構造を有する有機質多孔体（例えばウレタンフォ
ーム）に含浸させ、乾燥させる。その後、これらを加熱
して有機質多孔体及びバインダーを燃焼除去するととも
に、ガラス粉末を焼結し、結晶化させることにより、三
次元網状構造を有する多孔質結晶化ガラスを得ることが
できる。Further, the crystallized glass porous body has an average pore diameter of 2
0～2000Myuemu, it is preferable that a porosity of 66-95%. That is, if the average pore diameter is smaller than 20 μm, new bone cannot enter, and if it is larger than 2000 μm, sufficient mechanical strength cannot be obtained. If the porosity is less than 66%, the porosity tends to include independent pores, and the area in contact with the body fluid is reduced. For this reason, when an osteogenesis promoting substance is attached, the biological activity is significantly reduced. In addition, it becomes impossible to attach and impregnate a sufficient amount of the bone formation promoting substance. On the other hand, the porosity is 95
%, The skeletal structure of the porous body tends to collapse, and sufficient mechanical strength cannot be obtained. In order to produce a crystallized glass porous body having a three-dimensional network structure, first, a crystalline glass powder is mixed with water and a binder (eg, polyvinyl alcohol) to form a slurry, and then the slurry is mixed with an organic material having a three-dimensional network structure. The porous body (for example, urethane foam) is impregnated and dried. Thereafter, these are heated to burn and remove the organic porous material and the binder, and the glass powder is sintered and crystallized, whereby a porous crystallized glass having a three-dimensional network structure can be obtained.
【００１３】本発明において使用する骨形成促進物質
は、主に哺乳類等の脊椎動物の骨の灰分を除去した有機
基質の粉末である脱灰骨粉末や、それを精製して得られ
る骨形成因子のことである。この骨形成因子は、未分化
の間葉系細胞に対して細胞外から作用して、その遺伝形
質を軟骨細胞や骨芽細胞へと誘導し、骨組織を形成させ
る働きをする。The osteogenesis-promoting substance used in the present invention is mainly demineralized bone powder which is a powder of an organic matrix obtained by removing ash from bones of vertebrates such as mammals, and osteogenic factors obtained by purifying the same. That is. The osteogenic factor acts extracellularly on undifferentiated mesenchymal cells, induces its genetic traits to chondrocytes and osteoblasts, and functions to form bone tissue.
【００１４】なお、本発明の結晶化ガラス製多孔質イン
プラント材を作製するには、例えば骨形成促進物質を分
散させた生理食塩水に、先記したような方法で作製した
結晶化ガラス多孔体を浸せばよい。In order to prepare the crystallized glass porous implant material of the present invention, for example, a crystallized glass porous body prepared by a method as described above in a physiological saline in which an osteogenesis promoting substance is dispersed is used. Just soak it.
【００１５】[0015]
【実施例】以下、本発明の結晶化ガラス製多孔質インプ
ラント材を、実施例及び比較例に基づいて説明する。EXAMPLES The porous implant material made of crystallized glass of the present invention will be described below based on examples and comparative examples.
【００１６】表１は、本発明の実施例（試料No. １〜
３）及び比較例（試料No. ４）を示すものである。Table 1 shows examples of the present invention (samples No. 1 to No. 1).
3) and Comparative Example (Sample No. 4).
【００１７】[0017]
【表１】 [Table 1]
【００１８】（実施例）試料No. １〜３は次のようにし
て作製した。(Example) Sample Nos. 1 to 3 were produced as follows.
【００１９】まず、ＳｉＯ2 ３４．０％、Ｐ2 Ｏ5１
６．２％、ＣａＯ ４４．７％、ＭｇＯ ４．６％、Ｆ
2 ０．５％の組成になるようにガラス原料を調合し、白
金坩堝にいれて１４００〜１６００℃で３時間溶融し、
ロール成形した後、ボールミルにて粉砕し、２００メッ
シュの篩で分級した。このガラス粉末 1００重量％に対
して、水６０％、ポリビニルアルコール３％を混合して
スラリーとし、このスラリーを平均孔径の異なるウレタ
ンフォームにそれぞれ適当量含浸して乾燥させた。その
後、これらのウレタンフォームを１時間に３０〜３００
℃の速度で昇温し、１０００〜１２００℃で焼成するこ
とにより、三次元網状構造を有し、平均孔径１２０〜５
００μｍ、気孔率７０〜８５％の多孔体を得た。なお、
得られた多孔体はすべてアパタイト、ウオラストナイ
ト、及びジオプサイドを析出していた。[0019] First of all, SiO 2 34.0%, P 2 O 5 1
6.2%, CaO 44.7%, MgO 4.6%, F
2 Mix the glass raw materials so as to have a composition of 0.5%, put in a platinum crucible and melt at 1400-1600 ° C. for 3 hours,
After roll forming, the mixture was pulverized with a ball mill and classified with a 200-mesh sieve. To 100% by weight of this glass powder, 60% of water and 3% of polyvinyl alcohol were mixed to form a slurry, and the slurry was impregnated with urethane foams having different average pore sizes in appropriate amounts, and dried. Then, these urethane foams are added in an amount of 30 to 300 per hour.
By heating at a rate of 1000 ° C. and firing at 1000 to 1200 ° C., it has a three-dimensional network structure and an average pore diameter of 120 to 5
A porous body having a thickness of 00 µm and a porosity of 70 to 85% was obtained. In addition,
All of the obtained porous bodies had precipitated apatite, wollastonite, and diopside.
【００２０】また、家兎の長骨骨幹部を切断、粗砕し、
付着する軟組織及び骨髄を除去した後、冷却脱イオン水
で反復洗浄し、さらにエタノール及びジエチルエーテル
で反復洗浄した。次いでこの骨粗砕片を冷却、インパク
トミルで粉砕した後、ふるいにかけ、粒子径７５〜４５
０μｍの骨粉末を得た。さらにこの粉末を０．５モル塩
酸に３時間浸して脱灰した後、脱イオン水、エタノー
ル、ジエチルエーテルで反復洗浄し、凍結乾燥して骨形
成促進物質を得た。In addition, the long bone diaphysis of a rabbit is cut and crushed,
After removing the attached soft tissue and bone marrow, the cells were repeatedly washed with cold deionized water, and further repeatedly with ethanol and diethyl ether. Next, the coarse crushed bone fragments were cooled, pulverized by an impact mill, and then sieved to obtain a particle size of 75 to 45.
0 μm bone powder was obtained. The powder was further immersed in 0.5M hydrochloric acid for 3 hours to demineralize, then repeatedly washed with deionized water, ethanol and diethyl ether, and freeze-dried to obtain an osteogenesis promoting substance.
【００２１】次に、骨形成促進物質を生理食塩水に分散
させた後、１０×１５×２ｍｍの大きさに切断した結晶
化ガラス多孔体をこの生理食塩水に浸して試料を得た。Next, after the osteogenesis promoting substance was dispersed in physiological saline, the crystallized glass porous body cut into a size of 10 × 15 × 2 mm was immersed in this physiological saline to obtain a sample.
【００２２】（比較例）実施例と同一のガラス原料を実
施例と同様にして溶融し、１０×１５×２ｍｍの大きさ
に成形した後、１時間に３０〜３００℃の速度で昇温
し、１０５０℃で焼成することによって、アパタイト、
ウオラストナイト、及びジオプサイドが析出した結晶化
ガラス緻密体を作製した。(Comparative Example) The same glass raw material as in the example was melted in the same manner as in the example, formed into a size of 10 × 15 × 2 mm, and then heated at a rate of 30 to 300 ° C. per hour. Apatite by firing at 1050 ° C.
A dense crystallized glass body on which wollastonite and diopside were deposited was prepared.
【００２３】次いでこの緻密体を、骨形成促進物質を分
散させた生理食塩水に浸して試料No. ４を得た。Next, the dense body was immersed in a physiological saline in which an osteogenesis promoting substance was dispersed to obtain a sample No. 4.
【００２４】このようにして得られた各試料を、家兎の
けい骨に人為的に作製した欠損部（１０×１５×２ｍ
ｍ）に移植した後、２〜２４週間後に移植部分を摘出
し、生体骨との引き剥がし強度を測定した。なお表１中
の各数値は、成熟家兎１０例の平均値である。Each of the samples thus obtained was inserted into a trocar of a rabbit by artificially creating a defect (10 × 15 × 2 m).
After transplantation in m), the transplanted portion was excised 2 to 24 weeks later, and the peel strength from the living bone was measured. In addition, each numerical value in Table 1 is an average value of 10 mature rabbits.
【００２５】表１から明らかなように、実施例である試
料No. １〜３は、比較例である試料No. ４に比べ、早期
に生体骨と結合することがわかる。As is clear from Table 1, it can be seen that Sample Nos. 1 to 3 which are Examples are bonded to living bone earlier than Sample No. 4 which is a Comparative Example.
【００２６】なお、析出結晶はＸ線回折により求めた。The precipitated crystals were obtained by X-ray diffraction.
【００２７】[0027]
【発明の効果】以上説明したように、本発明の結晶化ガ
ラス製多孔質インプラント材は、結晶化ガラスの生体活
性をほとんど低下させることなく、十分な骨形成促進効
果を得ることができるために、生体骨と早期に結合する
ことが可能であり、骨欠損部等に使用するインプラント
材として好適である。As described above, the porous implant material made of crystallized glass according to the present invention can provide a sufficient bone formation promoting effect without substantially reducing the biological activity of the crystallized glass. It can be bonded to living bone at an early stage, and is suitable as an implant material used for a bone defect or the like.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.7，ＤＢ名) A61L 27/00 ──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int. Cl. 7 , DB name) A61L 27/00
Claims (2)
オプサイドの少なくとも１種を析出した三次元網状構造
を有する結晶化ガラス多孔体に、骨形成促進物質を付着
又は含浸させてなることを特徴とする結晶化ガラス製多
孔質インプラント材。1. A three-dimensional network structure in which at least one of apatite, wollastonite and diopside is precipitated.
A porous implant material made of crystallized glass, characterized by adhering or impregnating an osteogenesis promoting substance to a crystallized glass porous body having the following .
〜２０００μｍ、気孔率が６６〜９０体積％であること
を特徴とする請求項１の結晶化ガラス製多孔質インプラ
ント材。2. The crystallized glass porous body has an average pore diameter of 20.
～2000Myuemu, crystallized glass porous implant material of claim 1, porosity and wherein the 66 to 90 vol% der Turkey.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3024011A JP3063781B2 (en) | 1991-01-24 | 1991-01-24 | Crystallized glass porous implant material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3024011A JP3063781B2 (en) | 1991-01-24 | 1991-01-24 | Crystallized glass porous implant material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04240454A JPH04240454A (en) | 1992-08-27 |
| JP3063781B2 true JP3063781B2 (en) | 2000-07-12 |
Family
ID=12126612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3024011A Expired - Lifetime JP3063781B2 (en) | 1991-01-24 | 1991-01-24 | Crystallized glass porous implant material |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3063781B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003261747A1 (en) * | 2003-08-27 | 2005-03-29 | Makoto Ogiso | Structural body constituted of biocompatible material impregnated with fine bone dust and process for producing the same |
-
1991
- 1991-01-24 JP JP3024011A patent/JP3063781B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04240454A (en) | 1992-08-27 |
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