JP2994993B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic composition having excellent hair-growth effects, hair loss-preventing effects, feeling of use and safety.

[0002]

2. Description of the Related Art Conventionally, hair restoration cosmetics are known which contain blood circulation promoting substances such as pepper tincture and nicotinic acid derivatives, and amino acids and vitamins which are nutritional components of hair. Further, many medical hair restorers and cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003]

However, the blood circulation promoting substances used hitherto have the drawbacks that they are highly irritating to the skin, have a limited amount, and have a short duration of blood circulation promotion. In addition, there is also a problem that the hair nutrient has low permeability to the skin at a low concentration, and its effect is not sufficiently exhibited by itself.

[0004] By the way, male pattern baldness is said to be one of the causes of the excessive action of male hormones. However, phenomena such as poor circulation, decreased activity of hair matrix cells, hyperplasia of sebaceous glands, and fibrosis of the scalp, etc., have been reported. It is presumed that it is caused by complicated intertwining.

[0005] However, in order to suppress a decrease in the activity of the hair matrix and the enlargement of the sebaceous glands, which are said to be caused by the excessive action of male hormones, the hair growth action is exhibited even if a male hormone inhibitor or the like is simply used as a hair restorer. At present it does not reach. In addition, good results cannot be obtained even when the hair matrix activator or the blood circulation promoter is used alone.

As means for solving the above-mentioned problems, a number of hair-growth and hair-growing agents have been proposed, such as Japanese Patent Application Laid-Open Nos. 5-58850, 5-139936, and 5-170625. However, no remarkable hair-growth effect was found even when a substance that promotes peripheral blood flow and activates hair matrix cells was used alone.

Further, Japanese Patent Application Laid-Open No. 63-280009 discloses that an extract of tea leaves obtained by storing fresh tea leaves under anaerobic conditions and then performing a steam heat treatment and / or a dry heat treatment is used to obtain solid extracts of the tea leaves. A hair-growth cosmetic containing 0.1% by weight or more has been proposed, but if it is less than 0.1%, the hair-growth and hair-growth effects are not sufficiently exhibited, and moreover, 0.1% by weight or more is used. Even so, further improvement in the hair growth and hair growth effects has been required. In addition, the hair growth cosmetic composition containing the tea leaf extract also has a problem in that the tannin contained in the tea leaf extract causes a feeling of tingling on the hair.

Further, Japanese Patent Application Laid-Open No. Hei 2-121911 discloses that gentian extract is 18 to 21% by weight, carrot extract is 14 to 18% by weight, saffron extract is 5 to 7% by weight, and corn extract is 16 to 20% by weight. , Sensou extract 29-
A hair-growth cosmetic containing 46% by weight and 1-5% by weight of a placenta extract has been proposed. However, in order to obtain a hair-growth effect, the present invention incorporates each extract at a high concentration.
There was a peculiar off-flavor, stickiness and inferior usability, and skin irritation in some cases.

In view of such circumstances, the present inventors have conducted intensive studies on substances that promote peripheral blood flow in the scalp and activate hair matrix cells. The hair-growth cosmetic containing the tea leaf extract obtained by steam heat treatment and / or dry heat treatment after storage and the gentian extract is an object of the present invention due to the synergistic effect of each component. While exhibiting excellent hair-growing and hair-growing effects, there is no sticky feeling and no tingling sensation, and it has excellent usability and
The inventors found that there was no skin irritation, and completed the present invention.

[0010]

That is, the present invention contains an extract of tea leaves obtained by storing fresh tea leaves under anaerobic conditions and then performing a steam heat treatment and / or a dry heat treatment, and a gentian extract. The object of the present invention is achieved by a hair nourishing cosmetic.

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The extract of tea leaves used in the present invention is an extract obtained by easily extracting according to the method described in JP-A-63-280009, or an extract obtained by concentrating and drying the extract. It is an evaporation residue. Specifically, plucked tea [Thea sinensis L .; (Theaca
e)] After storing the leaves in a sealed container and completely replacing the air in the container with an inert gas such as carbon dioxide gas or nitrogen gas, at room temperature for 3 hours or more (preferably 5 hours or more, more preferably For at least 8 hours). Then, the tea leaves are taken out of the container and subjected to steam heating treatment for 10 to 30 minutes, or heating treatment at 80 ° C to 100 ° C, or both, as in the normal tea production process. The types of fresh tea leaves that are subjected to the above-described processing are
It can be applied to any varieties such as allies and the harvest time is not particularly limited. The method of extracting tea leaves is an ordinary method.For example, in an extractor equipped with a reflux device, tea leaves are mixed with a solvent such as water, a water-miscible organic liquid, or a mixture of a water-miscible organic liquid and water. Immersion in the solvent at a boiling point of 30 to
Extract for 60 minutes. This extract may be concentrated and dried under reduced pressure, or may be purified by activated clay, chromatography, or the like, if necessary.

The water-miscible organic liquid (hydrophilic organic liquid) in the above-mentioned solvent includes, for example, glycols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and glycerin. And polyhydric alcohols such as maltitols, lower monohydric alcohols such as ethyl alcohol, propyl alcohol and butyl alcohol, water-miscible ketones such as acetone and methyl ethyl ketone, and tetrahydrofuran.

The amount of the tea leaf extract used in the present invention is determined by examining the range showing the hair-growth effect, the hair loss-preventing effect, and the safety to the skin, which are the objects of the present invention. As a standard, 0.
0001 to 5.0% by weight (hereinafter abbreviated as wt%), more preferably 0.002 to 0.5% by weight.
However, it is preferable from the viewpoints of a hair growth effect, a hair loss preventing effect, and a feeling of use (there is no sticky feeling and no tingling).

The extract of gentian used in the present invention is gentian [Gentian lutea].
Linne (Gentianaceae)], water, ethanol, propylene glycol,
It is an extract obtained by extraction with 1,3-butylene glycol or a mixture thereof, or an evaporation residue obtained by concentrating and drying the extract.

The amount of the gentian extract used in the present invention was determined in consideration of the range of hair growth effect, hair loss prevention effect, and safety to the skin, which are the objects of the present invention. 0.0001 to 5.0% by weight (hereinafter referred to as wt%) in terms of the evaporation residue of the gentian extract on the basis of
Is abbreviated), more preferably 0.002 to
0.5 wt% is preferable from the viewpoints of a hair growth effect, a hair loss preventing effect, and a feeling of use (there is no sticky feeling and no tingling).

The hair nourishing cosmetic composition of the present invention can be used in a conventional manner, for example, for hair tonic, hair lotion, hair cream, hair conditioner, shampoo, rinse,
It can be manufactured and used in dosage forms such as hair gel, hair mist, and hair foam.

The hair restoration cosmetic composition of the present invention is applied or sprayed on a topical (scalp) intended for the purpose of hair restoration, hair growth and / or hair loss prevention according to the dosage form.

The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0020]

EXAMPLES The present invention will be described below in detail with reference to examples and the like, but the present invention is not limited to these examples. The test method used in the present invention is as follows.

(1) Mouse Hair Growth Promoting Effect Test Method The skin at the center of the back of a C3H mouse (male, 8 weeks old, average weight 35 g) was cut with an electric clipper, and the hair was completely removed with a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part once a day, 0.2 ml per animal. A group of 10 animals was used for one sample. In addition, the base alone (control product) was applied as a control group. On the 14th day after the start of the experiment, the animals were sacrificed and photographs of the skin of the test area were taken. Next, take the picture into the image analysis device,
First, the shaved area (A) and the hair growth area (B) were determined, and the hair growth rate (%) = [(B) / (A)] × 100 was calculated for each animal. Finally, the value obtained by dividing the average value of each group of the examples or comparative examples by the average value of the control group was used as a hair growth promoting effect in the determination.

(2) Human hair growth promoting effect test method Male test subject 1 in her 30s and 40s with reduced hair growth
The hair at the top of the head was shaved into a circular shape having a diameter of about 7 mm. One and three days after shaving, the method of Hayashi et al. (British Journal of Dermatology, 12
5, p. 123, 1991), the hair growth rate was determined for the hair at the target site (about 30 to 40 hairs), and the average value was calculated (A). Next, a sample of each of the examples, comparative examples, and the control product was placed twice daily in the morning and evening around the test site for each subject,
About 3 ml was applied and massaged well. The hair growth rate at the same site was measured in the same manner three months after the start of the test.
The average (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.

(3) Practical test method Twice in the morning and evening, 6 consecutive times on the heads of 20 male pattern baldness patients
The effect after applying the sample for a month was evaluated. The test results are for hair growth and hair loss prevention.
The number of respondents who answered "the hair has become bristle or has increased bristles" and "the hair loss has decreased" are shown.

(5) Tactile test method When each sample was applied to hair using panelists of 10 men, the results of questionnaires on stickiness and squeakiness were determined as follows.

[0025]

[Table 1]

The tea leaf extract and the gentian extract used in the following Examples and Comparative Examples were produced by the following production methods.

(1) Extract of tea leaves 10 kg of fresh tea leaves are put in a nitrogen stream for 4 hours, mashed, roasted in a kettle, and dried. Add purified water 3
Add 0 l, heat and extract for 2 hours, then cool and filter. The residue is treated twice with 20 l of purified water. The filtrates were combined, and 20 l of a synthetic adsorbent (Diaion HP-20, manufactured by Mitsubishi Kasei Co., Ltd.) was added thereto. The mixture was stirred at room temperature for about 2 hours, filtered, and the filtrate was concentrated under reduced pressure to about 1% of concentrated liquid. 0.0 kg was obtained. Add about 0.
After adding 4 kg, the mixture was allowed to stand in a cool place for 7 to 10 days, and the resulting deposits and precipitates were removed. A 30% by volume ethanol solution was added to obtain 1.5 kg of a product. The product was a brown transparent liquid with a slightly peculiar smell. The evaporation residue of this product was 5 to 10% by weight.

(2) Method for producing gentian extract 1000 g of dried root of "Gentian" of Japan was extracted with purified water by heating for about 12 hours, 400 g of propylene glycol was added as a stabilizer, and purified water was further added. Extract 1
000 g were obtained. This product was a light brown transparent liquid with a slightly peculiar smell. The evaporation residue of this product was 2 to 6% by weight.

Examples 1-5, Comparative Examples 1-6, Control (Heart Tonic) In the raw material composition shown in Table 2, an active ingredient was blended as shown in Table 3 to prepare a hair tonic, and the above-mentioned various tests were carried out. Was carried out.

[0030]

[Table 2]

[0031]

[Table 3]

(1) Preparation Method After dissolving the component (B) shown in Table 2 in the component (A), the component (C) was added, and the mixture was stirred, dispersed and filled into a container. At the time of use, the contents were uniformly shaken and used.

(2) Characteristics Table 3 shows the results of various tests of each hair tonic. As shown in Table 3, Comparative Examples 1 to 5 had low mouse hair growth promoting effects and human hair growth promoting effects, and were inferior in the results of practical tests and touch tests. On the other hand, the hair tonics of the present invention of Examples 1 to 5 exhibited high mouse hair growth promoting effect and human hair growth promoting effect, and the results of practical tests were also good. In addition, when the hair tonic of each example was used, there was no sticky feeling and no tingling at the time of use, and the feel at the time of use was excellent. Furthermore, inflammation in mice and humans,
No other symptoms considered to be side effects were exhibited, and it was clear that the hair tonic of the present invention was also excellent in safety. In addition, about the hair growth rate in the control product in Table 3, the comparative example 2, 3, 5, 6, and the hair tonic mouse of Example 2,
FIG. 1 shows the results obtained by examining the significant difference between the samples by the t-test.
As a result, the second embodiment control sample, with respect to Comparative Example 2, 3 and 5, that there is a closed position hair growth promoting effect at a 1% risk rate were either bright et <br/>.

[0034]

EFFECT OF THE INVENTION The hair-growing cosmetic composition of the present invention is excellent in hair-growth effect and hair loss-preventing effect, has no sticky feeling and no tingling feeling, is excellent in use feeling, and is also excellent in safety.

[Brief description of the drawings]

FIG. 1 is a diagram showing the hair growth rate in mice of Examples, Comparative Examples and Controls.

────────────────────────────────────────────────── ─── Continuation of front page (56) References JP-A-63-280009 (JP, A) JP-A-2-121911 (JP, A) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 7/06-7/135

Claims (1)

(57) [Claims] Claims 1. After storing fresh tea leaves under anaerobic conditions,
A hair growth cosmetic comprising an extract of tea leaves obtained by steam heat treatment and / or dry heat treatment, and an extract of gentian.