JP2814085B2 - Hair restoration - Google Patents

Description

The present invention relates to a novel and safe crude drug extract or a crude drug extract containing a surfactant and a surfactant.
The present invention relates to a hair nourishing material excellent in the effects of preventing hair loss, promoting hair growth, hair growth and the like.

[Prior Art] Conventionally, hair tonics containing various agents have been known. For example, vitamins such as vitamin B, amino acids such as methionine, vasodilators such as acetylcholine derivatives, anti-inflammatory agents such as purple root extract, female hormones such as estradiol, and skin function enhancers such as cepharanthin are compounded. It is used for the prevention and treatment of alopecia.

However, conventional hair restorations are said to be effective in preventing and improving dandruff, Kayumi, hair loss and the like, and to promote growth and hair growth, but none of them have yet obtained satisfactory effects.

[Problems to be Solved by the Invention] The present inventors have conducted intensive studies on hair restorations that are effective in preventing hair loss, hair growth, and the like, and have excellent safety. As a result, one or two or more specific crude drug extracts are obtained. Or found that this problem can be solved by containing one or more of these specific crude drug extracts and a specific surfactant,
The present invention has been completed.

[Means for Solving the Problems] That is, the invention according to claim 1 is characterized in that Aogiri, Ammaroku, Ubai, Nettle, Okucriharan, Ogi, Ouro, Cakkon, Gubak, Cahi, Gedokushi, Koso, Goshi, Kobushi, Sankyu, Teuchigurumi, Seiko,
A group consisting of the following: Is extracted with a solvent selected from hot water, alcohol and hydrous alcohol, or a concentrated hair product containing one or two or more concentrated extracts thereof.

According to a second aspect of the present invention, one or more of the crude extract extract or the concentrated and dried product thereof according to the first aspect, and a carboxylic acid group, a sulfonic acid group, a sulfate ester group, and a phosphate ester group are incorporated in the molecule. One or two or more anionic surfactants having one or more and an amphoteric surfactant having a nitrogen atom in the molecule, a semipolar surfactant, a nonionic surfactant, and a cationic surfactant. A hair tonic characterized by containing one or more kinds.

According to a third aspect of the present invention, there is provided one or more of the extract of the crude drug according to the first aspect or a concentrated and dried product thereof, and carboxybetaine, an imidazoline derivative, an aminocarboxylate, a sulfobetaine, an aminobetaine, and dimethyllaurylamine. Oxides, one or more of bis- (2-hydroxyethyl) laurylamine oxides, fatty acid alkanolamides, polyoxyethylene fatty acid amides,
A hair restorer comprising an alkanolamine ester and one or more polyoxyethylene alkylamines.

The invention according to claim 4 is based on Aogiri, Anmarok, Ubay,
Stinging nettle, giant cricket, giant gourd, greed, cuckoo, gubak, keihi, gedokushi, gokahi, koso, gomin, kobushi, konotegasiwa, sankyu, chimpi, teuchigurumi, seiuko, sansho, dokuyoishika,
The extract is selected from the group consisting of shobu, shobak, birch, elm, ryokyo, ryoyou, yoshishi, shikoku, tsuyou, syakugo, ren, mokusei, hanmyo, hakuhyou, makuwauri, hakuko, hange, hakusen, hakusho, hakuyou. And one or more of the above and the general formula (A) (Wherein R ₁ , R ₂ and R ₃ represent a linear or branched saturated or unsaturated hydrocarbon group having 1 to 2 carbon atoms, and at least one of R ₁ , R ₂ and R ₃ is Represents a straight-chain or branched, saturated or unsaturated hydrocarbon group having 8 or more carbon atoms.), A general formula (B) (Wherein R ₄ represents a straight-chain or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms) or the general formula (C) (Wherein R ₅ represents a linear or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms, and n represents an integer of 1 to 5). A hair restorer characterized by containing two or more types.

The invention according to claim 5 is the crude drug extract in claim, wherein the crude drug selected from the group is an extracted extract obtained by extracting with a solvent selected from hot water, alcohol, and hydrous alcohol, or a concentrated dried product thereof. A hair tonic characterized by the following.

 Hereinafter, the configuration of the present invention will be described in detail.

The crude drug extract according to claims 1 to 3 is an extract obtained by extracting the crude drug with a solvent selected from hot water, alcohol, and hydrous alcohol, or a concentrated dried product thereof.
The method for extracting the crude drug extract according to claim 4 is not particularly limited, but the above method is preferable. Examples of alcohols and hydrous alcohols include lower alcohols such as methanol and ethanol, hydrous lower alcohols, polyhydric alcohols such as propylene glycol and 1-3 butylene glycol, and hydrous polyhydric alcohols.

The amount of the crude drug extract in the present invention is 0.005 to 10% by weight, preferably 0.01 to
5% by weight. If the amount is less than 0.005% by weight, the effects of the present invention are not sufficiently exhibited, which is not preferable.

Examples of the anionic surfactant having one or two or more carboxylic acid groups, sulfonic acid groups, sulfate ester groups, and phosphate ester groups in the molecule according to claim 2 include the following. Examples of those having a carboxylic acid group include fatty acid soaps, ether carboxylic acids and salts thereof, and carboxylic acid salts such as condensates of amino acids and fatty acids. As those having a sulfonic acid group, alkyl sulfonates,
Examples include sulfosuccinic acid, ester sulfonate, alkyl allyl and alkyl naphthalene sulfonate, N-acyl sulfonate, and formalin condensed sulfonate. Examples of those having a sulfate group include sulfated oils, ester sulfates, alkyl sulfates, ether sulfates, alkyl allyl ether sulfates, and amide sulfates. As those having a phosphate group,
Alkyl phosphate, amide phosphate, ether phosphate, alkyl allyl ether phosphate and the like can be mentioned.
One or more of these are arbitrarily selected.

Examples of the amphoteric surfactant, semipolar surfactant, nonionic surfactant, and cationic surfactant having a nitrogen atom in the molecule according to claim 2 include the following. As the amphoteric surfactant, N, N-dimethyl-N-lauryl-N-carboxymethylammonium betaine, N, N-
Carboxybetaines such as dimethyl-N-oleyl-N-carboxymethylammonium betaine, 2-lauryl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethylimidazoli Imidazoline derivatives such as ammonium betaine; aminocarboxylates such as N-cocoalkyl-β-aminopropionic acid-sodium salt; N-cocoalkyl-β-iminodipropionic acid-di-soda salt; sulfobetaine; aminobetaine and the like. .
Examples of the semipolar surfactant include dimethyl lauryl amine oxide, bis- (2-hydroxyethyl) lauryl amine oxide, and the like. Examples of the nonionic surfactant include fatty acid alkanolamides, polyoxyethylene fatty acid amides, esters of alkanolamines, and polyoxyethylene alkylamines. Examples of the cationic surfactant include fatty acid amine salts, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridium salts, imidazolium salts and the like. One or more of these are arbitrarily selected.

As the carboxybetaine according to claim 3, N, N-
Dimethyl-N-lauryl-N-carboxymethylammonium betaine, N, N-dimethyl-N-oleyl-N-
Carboxymethyl ammonium betaine and the like,
Examples of the imidazoline derivative include 2-lauryl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-N-carboxymethyl-N-
Hydroxyethyl imidazolinium betaine and the like, and as the aminocarboxylate, N-cocoalkyl-
β-aminopropionic acid sodium salt, N-cocoalkyl-
β-iminodipropionic acid-di-soda salt and the like.

Specific examples of the amine oxide represented by the general formula (A) according to claim 4 include dimethyl lauryl amine oxide, dimethyl myristyl amine oxide, dimethyl cetyl amine oxide, dimethyl stearyl amine oxide, dimethyl oleyl amine oxide, and dimethyl behenyl amine oxide. And methyl dilauryl amine oxide.

In the invention according to claim 4, the general formula (A):
One or more of the amine oxides represented by (B) or (C) are arbitrarily selected and used.

The total amount of the anionic surfactant according to claim 2 and an amphoteric surfactant having a nitrogen atom in the molecule, a semipolar surfactant, a nonionic surfactant or a cationic surfactant, is a total amount of the hair restorer. The content is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight based on the total amount. In addition, the ratio of an anionic surfactant and an amphoteric surfactant having a nitrogen atom in the molecule, a semipolar surfactant, a nonionic surfactant or a cationic surfactant, in a molecular ratio of 20: 1 to 1:20 is preferred, and more preferably 10: 1 to 1:10.

The carboxybetaine, imidazoline derivative, aminocarboxylate, sulfobetaine, aminobetaine, dimethyllaurylamine oxide, bis- (2
-Hydroxyethyl) laurylamine oxide and one or more fatty acid alkanolamides, polyoxyethylene fatty acid amides, esters of alkanolamines, and one or more polyoxyethylene alkylamines, 0.001-10% by weight of total hair
And more preferably 0.01 to 5% by weight.
Further, one or more of carboxybetaine, imidazoline derivative, aminocarboxylate, sulfobetaine, aminobetaine, dimethyllaurylamine oxide, bis- (2-hydroxyethyl) laurylamine oxide, fatty acid alkanolamide, polyoxyethylene Fatty acid amide, ester of alkanolamine, the ratio with one or more of polyoxyethylene alkylamine is preferably 20: 1 to 1:20 in molecular ratio, more preferably
10: 1 to 1:10.

The compounding amount of the amine oxide represented by the general formula (A), (B) or (C) according to claim 4 is 0.000 of the total amount of the hair restorer.
01-20% by weight is preferred. If the amount is less than 0.0001% by weight, a sufficient hair-growth effect cannot be obtained, and if it exceeds 20% by weight, it is not preferable from the viewpoint of formulation and skin irritation.

The hair tonic charge according to the present invention, in addition to the above essential components, general purpose components usually used in hair revitalizing agents, such as vitamins B _6, vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhetinic acid And derivatives thereof, nicotinic acid esters such as benzyl nicotinate, cyclosporic acid, carpronium chloride, cepharanthin, oxendrone, diazoxide, minoxidil, ethinyl estradiol, etc., a hair growth agent or a hair growth assistant, hinokitiol, hexachlorophene, phenol, Antibacterial agents such as benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and bithionol; cooling agents such as menthol;
Drugs such as salicylic acid, zinc and derivatives thereof, lactic acid and alkyl esters thereof, organic acids such as citric acid, amino acids such as arginine, oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols, and glycerin , Polyhydric alcohols such as propylene glycol, fragrances, antioxidants, ultraviolet absorbers, pigments, alcohols such as ethanol, benzyl alcohol, isopropyl alcohol, water, humectants, thickeners and the like do not impair the effects of the present invention. It can be appropriately compounded within the range.

The hair restorer of the present invention may be any liquid form, emulsion, ointment, cream, gel, aerosol or any other dosage form applicable to the outer skin, and is used in the form of a tonic, conditioner, scalp treatment, shampoo, rinse, etc. .

[Examples] Next, the present invention will be described in detail with reference to examples.
The present invention is not limited to these. The compounding amount is% by weight.

Method for measuring hair growth effect (measurement of hair growth effect in mice) Using male C ₃ H mice (60 days after birth), the method of Ogawa et al. [N
ormal and Abnormal Epidermal Dif-ferentiation) M.
Seiji and IABernstein edited by the University of Tokyo Press]. That is, the back hair of a mouse is shaved to a size of about 2 × 4 cm, and a sample is applied once a day every day from the next day, and the change in the area ratio of the portion where hair regeneration has started is determined. A comparison was made. The sample was prepared by dissolving a dried product of each crude drug extract in 75% ethanol with stirring, adding a surfactant to the solution and dissolving it. The test used 75% ethanol as a control. Mouse 10 for each sample
The average value of the rate of change was determined for each animal. The results of the hair regeneration area after 20 days are shown in Table 1 in percentage.

Comparative Example 1 (1) 75% ethanol 100 Comparative Example 2 (1) 50% ethanol extract of dried assembly (0.2) (2) 75% ethanol Residue Comparative Example 3 (1) 70% ethanol extract of dried corn (dry) 0.2) (2) 75% ethanol residue Comparative Example 4 (1) Kuzin 50% ethanol extract (dried product) 0.2 (2) 75% ethanol residue Comparative Example 5 (1) 50% ethanol extract of ginseng ( (Dried product) 0.2 (2) 75% ethanol residue Example 1 (1) 50% ethanol extract of Aougiri (dried product) 0.2 (2) 75% ethanol residue Example 2 (1) 70% ethanol extract of Chinese cabbage ( (Dried product) 0.2 (2) 75% ethanol residue Example 3 (1) 50% ethanol extract of Mulberry (dry product) 0.2 (2) 75% ethanol residue Example 4 (1) Dimethyl laurylamine oxide 0.1 (2) 50% ethanol extract (dry matter) of Aougiri 0.1 (3) 75% ethanol residue Example 5 (1) Dimethyl stearylamine oxide 0.1 (2) Methanol extract of Chinese cabbage (dry matter) 0.1 (3) 75% ethanol residue Example 6 (1) Dimethyl lauryl amine oxide 0.1 (2) 50% ethanol extract of dried moss (dry matter) 0.1 (3) 75% ethanol Remaining Example 7 (1) Dimethyl stearyl amine oxide 0.1 (2) Stiletto 1 , 3-butylene glycol extract (dry) 0.1 (3) 75% ethanol residue Example 8 (1) dodecylbenzenesulfonate 0.05 (2) lauryl dimethylamine oxide 0.05 (3) 70% ethanol extract of Chinese cabbage (dry) ) 0.1 (4) 75% ethanol residue Example 9 (1) Sodium lauryl sulfate 0.04 (2) Dimethyl lauryl Amine oxide 0.06 (3) Ethyl extract of dried reed (dry matter) 0.1 (4) 75% ethanol residue Example 10 (1) Dimethylstearylamine oxide 0.075 (2) Sodium lauryl sulfate 0.025 (3) Hot water extract of birch (Dried product) 0.1 (4) 75% ethanol Residual Example 11 (1) Dimethylstearylamine oxide 0.15 (2) Monosodium lauryl phosphate 0.05 (3) 70% ethanol extract of calyx (dry product) 0.05 (4) 75% ethanol Residual Example 12 (1) Dimethylstearylamine oxide 0.03 (2) Sodium laurylmethyltaurine 0.02 (3) Methanol extract of eucrihalane (dry) 0.1 (4) Hot water extract of Ryokyo (dry) 0.05 (5) 75% ethanol residue Example 13 (1) Betaine laurylaminoacetate 0.03 (2) Uroyl diethanolamide 0.02 (3) 70% ethanol extract of hange (dry matter) 0.05 (4) Methanol extract of leopard (dry matter) 0.05 (5) Propanol extract of Teuchigurumi (dry matter) 0.05 (4) 75 % Ethanol Residual Example 14 (1) Dimethyl lauryl amine oxide 0.04 (2) Monosodium lauryl phosphate 0.01 (3) 70% ethanol extract of kebab (dry matter) 0.05 (4) Methanol extract of thympi (dry matter) 0.05 (5) Propanol extract of Gukahi (dry matter) 0.05 (6) 75% ethanol residue Example 15 (1) Dimethyllaurylamine oxide 0.03 (2) Sodium laurylmethyltaurine 0.02 (3) 70% ethanol extract of Ubay (Dried product) 0.05 (4) Methanol extract of anmarok (Dried product) 0.05 (5) Big propane Extract (dry) 0.05 (6) 75% ethanol residue Example 16 (1) betaine laurylaminoacetate 0.03 (2) lauroyl diethanolamide 0.02 (3) 75% ethanol extract of nettle (dry) 0.05 (4) ) Gedoxi methanol extract (dry) 0.05 (5) Hachsen propanol extract (dry) 0.05 (6) 75% ethanol residue Example 17 (1) Dimethyl oleylamine oxide 0.03 (2) Lauroyl diethanolamide 0.02 (3) ) 70% ethanol extract of makuwauri (dry product) 0.05 (4) Methanol extract of Chinese cabbage (dry product) 0.05 (5) Propanol extract of antelope (dry product) 0.05 (6) 75% ethanol residue Example 18 ( 1) Dimethyl lauryl amine oxide 0.05 (2) Sodium lauryl sulfate 0.01 (3) 70% ethanol of sankyu Extract (dry) 0.04 (4) Methanol extract of salmon (dry) 0.05 (5) Propanol extract of job (dry) 0.05 (6) 75% ethanol Residual Example 19 (1) Dimethyl oleylamine Oxide 0.06 (2) Monosodium lauryl glutamate 0.01 (3) 70% ethanol extract of corn (dry) 0.04 (4) Methanol extract of dry ginger (dry) 0.04 (5) Propanol extract of Konotegasiwa (dry) 0.05 (6) 75% ethanol residue As is clear from Table 1, the effect on hair regeneration was observed in each example.

Example 20 Hair tonic A tonic having the following composition was prepared, and its effect on symptoms such as dandruff, hair growth, and hair loss was examined in actual use.

20 men (aged) with symptoms such as dandruff, hair growth, and hair loss
24 to 60 years old) was applied once or twice a day in 1 to 5 ml portions for 4 months, and the results in Table 2 were obtained. It had excellent symptoms such as dandruff, hair growth and hair loss.

(1) Our 70% ethanol extract (dry product) 0.05 (2) 90% ethanol extract of cuckoo (dry product) 1.0 (3) Methanol extract of compost (dry product) 0.5 (4) Dimethyllaurylamine oxide 0.3 (5) Sodium lauryl sulfate 0.05 (6) Propylene glycol 5.0 (7) Sodium hyaluronate 0.01 (8) 75% ethanol Residue In Table 2 above, the effect was determined based on the following criteria.

1. Dandruff prevention effect test "Ineffective" means no improvement is seen despite treatment.

 "Effective" means that the occurrence of dandruff has been reduced.

 "Excellent effect" means that the occurrence of dandruff has stopped.

2. Hair growth test "Ineffective" means no improvement is seen despite treatment.

“Effective” means that hair growth is observed in more than 2/3 of the hair loss area.

 "Excellent effect" means that the hair has grown on the epilation area.

3. Hair loss effect test "Ineffective" means no improvement is seen despite treatment.

 "Effective" means that the progress of hair loss was reduced.

 "Effectiveness" means that hair loss has stopped.

Example 21 Hair Tonic (1) Methanol extract of Kobushi (dry matter) 0.05 (2) 80% ethanol extract of Konotesashiwa (dry matter) 0.05 (3) 1,3-butylene glycol extract of kosou (dry matter) 0.05 (4) 90% ethanol extract of Dried Bamboo (Dry) 0.05 (5) Hot water extract of Dokuyoishika (Dry) 0.05 (6) 70% ethanol extract of elm (Dry) 0.05 (7) Polyoxy Ethylene (8 mol) oleyl alcohol ether 0.05 (8) 1,3-butylene glycol 0.05 (9) 60% ethanol residue Example 22 Shampoo (1) Sodium cocoyl methyl taurine 6.0 (2) Lauryl dimethylamino acetate betaine 8.0 (3) Lauric acid diethanolamide 4.0 (4) Ethylene glycol fatty acid ester 1.5 (5) Propylene glycol 2.0 (6) Ryuyo 70% ethanol extract of crust (dry matter) 1.0 (7) 50% ethanol extract of ren (dry matter) 1.0 (8) Methanol extract of halibut (dry matter) 1.0 (9) Propylene glycol extract of blue gall ( (Dried product) 0.2 (10) Disodium edetate 0.1 (11) Appropriate amount of perfume (12) Purified water Remaining Example 23 Rinse (1) Stearyl trimethyl ammonium chloride 1.5 (2) Cetyl alcohol 2.0 (3) Silicon oil 3.0 (4) Polyoxyethylene (10 mol) oleyl alcohol ether 1.0 (5) Glycerin 5.0 (6) Mumbai extract of methanol (dry) 0.5 (7) Methanol extract of hakusen (dry) 0.5 (8) Hot water extraction of scallop (Dried product) 1.0 (9) 70% ethanol extract of leopard (Dried product) 1.0 (10) Purified water 84.0 (11) Preservative appropriate amount (12) UV absorber appropriate amount Example 24 Hair Cream (1) Beeswax 3.0 (2) Vaseline 15.0 (3) Liquid paraffin 42.0 (4) Polyoxyethylene (5 mol) stearic acid ester 3.0 (5) Polyoxyethylene (6 mol) oleyl alcohol ether 1.0 ( 6) 90% propanol extract of dried coconut (dry) 0.3 (7) 50% methanol extract of Ryokyo (dry) 0.2 (8) 70% ethanol extract of thyme (dry) 0.4 (9) Purified water 35.1 (10) Appropriate amount of fragrance (11) Preservative appropriate amount All of Examples 21 to 24 were excellent in hair-growth effect.

[Effects of the Invention] The hair restorer of the present invention contains a specific crude drug extract or a specific crude drug extract and a specific surfactant, so that various properties (e.g., For example, hair growth, hair growth, hair loss prevention effects, etc.).

──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Reiji Miyahara 1050 Nippa-cho, Kohoku-ku, Yokohama, Kanagawa Prefecture Inside Shiseido Research Laboratories (72) Inventor Keiichi Uchikawa 1050 Nippa-cho, Kohoku-ku, Yokohama, Kanagawa Shiseido Co., Ltd. In the laboratory (56) References JP-A-54-84038 (JP, A) JP-A-57-53401 (JP, A) JP-A-60-178805 (JP, A) JP-A-1-246211 (JP, A) JP-A-64-3125 (JP, A) JP-A-64-3126 (JP, A) Shanghai Science and Technology Publishing Company Shogakukan, edited by Chugakukan Dictionary (Vol. 3) (Showa 60-12-10). P. 1619-1621 Shanghai Science and Technology Publishing Company, Shogakukan Edition, “China Pharmaceutical Dictionary (Vol.4)” (Showa 60-12-10). 2420-2423 Extraordinary fragrance journal “Plant Science of Cosmetics: Development and Effective Utilization of Plant Ingredients” (Showa 61-5-1) Fragrance Journal 196 (58) Field surveyed (Int. Cl. ⁶ , DB name) A61K 7/00-7/50

Claims (5)

(57) [Claims] [Claim 1] Aogiri, Ammaroku, Ubai, Nettle, Okucriharan, Ogi, Ouro, Cuckon, Gubak, Keihi, Gedokushi, Kosou, Gomin, Kobushi, Sankyu, Teuchigurumi, Seiko, Sansho, Dokuyoishika, Shoubushi, Shobaku, Elm,
A crude drug selected from the group consisting of Ryokyo, Ryouyou, Yoshichi, Shikoku, Toyo, Hyakugo, Ren, Mokusei, Hanmyo, Fukyo, Makuwauri, Hakuko, Hange, Hakusho, Hakuyo, and a solvent selected from hot water, alcohol and hydrous alcohol A hair restorer comprising one or more of an extract or a concentrated dried product obtained by extracting the extract. 2. Aogiri, Amarok, Ubai, Nettle, Okucriharan, Ogi, Ouro, Cuckon, Gubak, Keihi, Gedokushi, Gokahi, Koso, Gomin, Kobushi, Konotegashiwa, Sankyu, Chimpi, Teuchigurumi, Seiko, Sansho, Dokuyo A group consisting of shobu, shobak, birch, elm, ryokyo, ryouyou, yoshishi, shikoku, tokyo, hakugo, ren, mokusei, hanmyo, hakuhyo, makuwauri, hakuko, hange, hakusen, hakusho, hakuyou. Water, alcohol, one or two or more extracted extracts obtained by extraction with a solvent selected from hydrous alcohols or concentrated and dried products thereof, and a carboxylic acid group, a sulfonic acid group, a sulfate group, and a phosphate group in the molecule Kind or One or more anionic surfactants having one or more species, and one or two or more amphoteric surfactants, semipolar surfactants, nonionic surfactants and cationic surfactants having a nitrogen atom in the molecule. Hair restorer characterized by containing at least one species. 3. Aogiri, Amarok, Ubai, Nettle, Okucriharan, Ogi, Oro, Cuckon, Gubak, Cahi, Gedokushi, Gokahi, Kosou, Gomin, Kobushi, Konotegashiwa, Sankyu, Chimpi, Teuchigurumi, Seiko, Sansho, Dokuyo A group consisting of shobu, shobak, birch, elm, ryokyo, ryouyou, yoshishi, shikoku, tokyo, hakugo, ren, mokusei, hanmyo, hakuhyo, makuwauri, hakuko, hange, hakusen, hakusho, hakuyou. Water, alcohol, one or two or more of an extract obtained by extraction with a solvent selected from hydrous alcohols or a concentrated dry product thereof, and carboxybetaine, an imidazoline derivative, an aminocarboxylate, a sulfobetaine, a Nobetain, dimethyl lauryl amine oxide, bis - (2-hydroxyethyl) and one or two or more of lauryl amine oxide, fatty acid alkanolamides, polyoxyethylene fatty acid amides,
A hair restorer comprising an alkanolamine ester and one or more polyoxyethylene alkylamines. 4. Aogiri, Ammaroku, Ubai, Nettle, Okucriharan, Ogi, Ouro, Cuckon, Gubak, Keihi, Gedokushi, Gokahi, Kosou, Gomin, Kobushi, Konotegashiwa, Sankyu, Chimpi, Teuchigurumi, Seiko, Sansho, Dokuyo A member selected from the group consisting of shobu, shobak, birch, elm, ryokyo, ryouyou, yoshishi, shikoku, tokyo, hiyakugo, ren, mokusei, hanmyo, hyohyo, makuwauri, hakuko, hange, hakusen, hakusho, hakuyou. One or more,
General formula (A) (Wherein R ₁ , R ₂ and R ₃ represent a linear or branched saturated or unsaturated hydrocarbon group having 1 to 2 carbon atoms, and at least one of R ₁ , R ₂ and R ₃ is Represents a straight-chain or branched, saturated or unsaturated hydrocarbon group having 8 or more carbon atoms.), A general formula (B) (Wherein R ₄ represents a straight-chain or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms) or the general formula (C) (Wherein R ₅ represents a linear or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms, and n represents an integer of 1 to 5). Hair restoration characterized by containing two or more kinds. 5. The crude drug extract is an extract obtained by extracting a crude drug selected from the group with a solvent selected from hot water, alcohol and hydrous alcohol, or a concentrated dried product thereof. The hair restorer according to claim 4.