JP2020511189A5 - - Google Patents

Claims (9)

A system (20) for heat-treating living tissue, the system (20) is:
An intermittent pulse energy source (22) that comprises less than 10 seconds, preferably less than 1 second, to create a first level of heat shock protein activation in the target tissue. Energy including wavelength or frequency, duty cycle, and pulse train duration to raise the temperature of the target tissue by up to 11 degrees Celsius, at least during the application of the pulse energy source to the target tissue over the first period. Equipped with an intermittent pulse energy source (22) with parameters ;
A means (28) for stopping the application of pulse energy to a target tissue for a time interval greater than the first period , the time interval being 3 seconds to 3 minutes, and most preferably 10 seconds. Means (28), including 90 seconds from
Means (28) for reapplying a pulsed energy source to the target tissue after the time interval, thereby causing heat shock protein activation in the target tissue without destroying or damaging the target tissue. It comprises means (28), which creates a second level of heat shock protein activation greater than the first level.
System (20) . The system of claim 1, wherein the parameters of the pulsed energy source are selected to raise the temperature of the target tissue from 6 degrees Celsius to 11 degrees Celsius. The system of claim 1 or 2, wherein the parameters of the pulsed energy source are selected to maintain an average temperature rise of the target tissue below 6 degrees Celsius over several minutes, or preferably below 1 degree Celsius over several minutes. The system according to any one of claims 1 to 3, wherein the pulse energy source includes a light beam, a microwave, a high frequency, or an ultrasonic wave. The system of claim 4, wherein the high frequency is about 3 to 6 MHz and has a duty cycle of about 2.5% to 5% and a pulse train duration of about 0.2 to 0.4 seconds. The system of claim 5, comprising a device for producing high frequencies having a coil radius of about 2-6 mm and a coil radius of about 13-57 amperes. The microwave frequency is about 10-20 GHz and has a pulse train duration of about 0.2-0.6 seconds, a duty cycle of about 2% -5%, and an average power of about 8-52 watts. The system according to claim 4. The light beam has a wavelength of about 530 nm to 1300 nm, a duty cycle of less than 10%, and a pulse train duration of about 0.1-0.6 seconds, and preferably the pulsed light beam is about 800 nm. The system of claim 4, having a wavelength of ~ 1000 nm and a power of about 0.5 ~ 74 watts. Ultrasound has a frequency of about 1 MHz to 5 MHz and a column duration of about 0.1 to 0.5 seconds.
The system of claim 4, which has a duty cycle of about 2% to 10% and a power of about 0.46 to 28.6 watts.