JP2018131417A - Anemia preventing/improving composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a novel anemia preventing/improving composition.SOLUTION: The present invention provides an anemia preventing/improving composition that contains a mineral component as an active ingredient, the composition to be administered in combination with a milk protein-containing composition. The composition may further contain a vitamin component and may be administered to a subject who is receiving exercise load.SELECTED DRAWING: None

Description

  The present invention relates to a composition for preventing or improving anemia.

  Anemia refers to a state in which the hemoglobin concentration falls below the lower limit of normal. Generally, when the hemoglobin concentration falls, the oxygen carrying capacity of the blood decreases, and various organs and tissues fall into an oxygen-deficient state. For this reason, in anemia patients, circulatory regulation such as increased heart rate and increased respiratory rate occurs to eliminate oxygen deficiency, causing slight fever, skin / mucosal pallor, increased heart rate, palpitation, shortness of breath, headache, tinnitus Various symptoms such as Anemia is prominent in women (especially young women) and is thought to be due to factors specific to women such as menstruation, pregnancy and excessive dieting. In other words, women are at higher risk of anemia than men.

  Typical measures for improving anemia include review of diet, intake of dietary supplements such as supplements, and treatment by drug administration. Since it is necessary to continue such effective measures against anemia, there is no concern about side effects even if taken for a long period of time, and it is expected to develop materials and intake plans that are safe and effective for anemia. Has been. As a food material for improving anemia, a whey protein concentrate composition containing iron (Patent Document 1) has been reported so far.

JP 2007-000094 A

  From the viewpoint of effectively improving anemia, the present inventors have conducted extensive research on food materials effective for anemia and their intake plans. As a result, it was found that the blood concentration and the reticulocyte count of somatomedin C, which is an index of hematopoiesis, increase by ingesting the mineral component-enriched composition and the milk protein-enriched composition together. The present inventors have also found that the combined intake of the mineral component-enhancing composition and the milk protein-enhancing composition suppresses the decrease in muscle mass such as skeletal muscle. The present invention is based on these findings.

  That is, an object of the present invention is to provide a novel composition for preventing or improving anemia.

According to the present invention, the following inventions are provided.
[1] A composition for preventing or ameliorating anemia, comprising a mineral component as an active ingredient, and ingested in combination with a milk protein-containing composition.
[2] The composition according to the above [1], further comprising a vitamin component.
[3] The above [1] or [2], wherein the mineral component is at least one selected from the group consisting of iron, sodium, potassium, calcium, magnesium, phosphorus, chlorine, zinc, copper and selenium. Composition.
[4] The vitamin component is at least one selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, folic acid, pantothenic acid, and biotin. The composition according to [2] or [3] above.
[5] The composition according to any one of the above [1] to [4], which is ingested by an exercised subject.
[6] The composition according to any one of [1] to [5], which is ingested by a woman at risk for anemia.
[7] The composition according to any one of [1] to [6], which suppresses a decrease in muscle mass.
[8] The composition according to any one of [1] to [7] above, for increasing the blood concentration of somatomedin C (IGF-1).
[9] The composition according to any one of the above [1] to [8] for increasing the reticulocyte count.
[10] The composition according to any one of [1] to [9], which is in a unit package form.
[11] The composition according to any one of [1] to [10] above, comprising 0.1 to 4.0 g of a mineral component as a daily intake.
[12] The composition according to any one of [1] to [11], wherein the milk protein-containing composition is in a unit package form.
[13] The composition according to any one of [1] to [12] above, wherein the milk protein-containing composition comprises 1 to 100 g of milk protein as a daily intake.
[14] The composition according to any one of [1] to [13], which is a food composition.
[15] A method for preventing or ameliorating anemia, which comprises ingesting or administering a mineral component-containing composition to a subject in combination with a milk protein-containing composition (excluding medical practice for humans).

  According to the present invention, there is provided a composition for preventing or improving anemia containing a mineral component as an active ingredient, which is taken together with a milk protein-containing composition. According to the present invention, it is advantageous in that it is possible to improve anemia and various symptoms without worrying about side effects.

Detailed description of the invention

  The composition of the present invention comprises a mineral component as an active ingredient. The mineral component can be one or more selected from the group consisting of iron, sodium, potassium, calcium, magnesium, phosphorus, chlorine, zinc, copper and selenium, preferably at least iron, zinc, copper and Those containing selenium, more preferably those containing at least iron and zinc, or those containing at least iron. In addition, in the composition of this invention, although a mineral component can be mix | blended as a raw material, the one part or all part may originate in other raw materials, such as vegetable juice and fruit juice mentioned later.

  The content ratio of the mineral component in the composition of the present invention is not particularly limited as long as the mineral component is contained in an effective amount for the prevention and improvement of anemia. For example, 0.04 to 3.2% by mass (Preferably, 0.08 to 1.6% by mass).

  The mineral component content in the composition of the present invention can be 0.1 to 4 g (preferably 0.2 to 2 g or 0.2 to 1 g) as the daily intake and dose for adults. In addition, the iron content in the composition of the present invention can be 2 to 55 mg (preferably 4 to 50 mg or 4 to 40 mg) as the daily intake and dose for adults.

  The composition of the present invention may further contain a vitamin component. The vitamin component is one or more selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, folic acid, pantothenic acid and biotin. Preferably, it contains at least vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid and biotin. In addition, in the composition of this invention, although a vitamin component can be mix | blended as a raw material, the one part or all part may originate in other raw materials, such as vegetable juice and fruit juice mentioned later.

  The content ratio of the vitamin component in the composition of the present invention can be, for example, 0.04 to 3.2% by mass (preferably 0.08 to 1.6% by mass). The vitamin component content in the composition of the present invention can be 0.1 to 4 g (preferably 0.2 to 2 g or 0.2 to 1 g) as the daily intake and dose for adults.

  The composition of the present invention may contain vegetable juice and fruit juice as raw materials, and may further contain food additives such as fragrances, sweeteners, emulsifiers, pH adjusters, and thickeners.

  The composition of the present invention is to be ingested or administered in combination with a milk protein-containing composition. In the present invention, the definition, classification, and production method of milk proteins can be referred to Japan Food Science July 1989, pages 42-48 and Milk General Dictionary (issued January 20, 1992, Asakura Shoten). In the present invention, milk protein is a group consisting of casein, milk protein concentrate (MPC), whey protein, whey protein concentrate (WPC), whey protein isolate (WPI), α-lactalbumin, β-lactoglobulin and lactoferrin. One or a plurality of species selected from the group consisting of at least MPC, preferably at least MPC, at least WPC, or at least casein and whey protein.

  The content ratio of the milk protein in the milk protein-containing composition can be, for example, 0.02 to 50% by mass (preferably 0.05 to 20% by mass). The milk protein content in the milk protein-containing composition can be, for example, 1 to 100 g (preferably 5 to 50 g or 5 to 25 g) as the daily intake and dosage for adults.

  The composition of the present invention and the milk protein-containing composition used in combination therewith can be provided in the form of a food or pharmaceutical composition. Here, “food” means health food, functional food, health functional food (for example, food for specified health use, nutritional functional food, functional label food), food for special use (for example, food for infants, food for pregnant women) , Food for sick persons). The form of “food” is not particularly limited, and may be, for example, a beverage form, a semi-liquid or gel form, or a solid form. The composition of the present invention may be a daily food (for example, a soft drink) or a food taken as a supplement, in which a mineral component and optionally a vitamin component are blended. The milk protein-containing composition to be used in combination with the composition of the present invention may be a daily ingested food containing milk protein (for example, a milk drink or a dairy product) or a food ingested as a supplement. Depending on the case, the food may further contain nutritional components such as calcium and vitamin B groups such as vitamin B6, or may be processed such as a low fat type.

  The composition of the present invention is for use in the prevention and improvement of anemia. Here, “anemia” means a state in which the blood hemoglobin concentration has dropped below the lower limit of normal (eg, healthy adult male: 13.0 g / dL, healthy adult female: 12.0 g / dL), and iron deficiency It shall be used in the meaning including sexual anemia. The composition of the present invention can also reduce or improve symptoms associated with anemia such as fatigue, fatigue, palpitation, shortness of breath, headache, and dizziness on standing. The composition of the present invention may be used for the treatment of anemia. In that case, the composition of the present invention can be carried out according to an aspect of prevention and improvement of anemia.

  The composition of the present invention can be ingested or administered to both men and women, but can preferably be ingested or administered to women at risk of anemia (for example, young women). Since the risk of anemia increases due to menstruation, pregnancy, childbirth, breastfeeding, excessive dieting, etc., the composition of the present invention is preferably suitable for women with high risk of such anemia (for example, women aged 18 to 45 years). Can be ingested or administered.

  The composition of the present invention can prevent and ameliorate anemia by using in combination with a milk protein-containing composition. However, the effect can be obtained by ingesting or administering the subject to an exercise load. It can be made to show more. Here, the exercise load means that the subject ingesting or administering the composition of the present invention continuously exercises, for example, one set of slow jogging (running at a slow speed for 1 minute, 30 seconds) Walking for 15 minutes) may be carried out 12 times a week (180 minutes / week). Slow jogging may also be performed over 12 sets per week. Slow jogging is preferably performed daily for 1 to 2 sets per day so as to be 12 sets per week, but may be performed for 3 to 6 days per week as long as 12 sets per week. In the present invention, instead of part or all of the above slow jogging, a motion with a momentum equivalent to that of the slow jogging (for example, running of about 6.4 km / hour) or a motion exceeding the momentum of the slow jogging is continuously performed. It goes without saying that you may go to.

  The amount of exercise corresponding to the slow jogging can be determined on the basis of MET (metabolic equivalent) which is an index representing energy consumption in physical activity. In other words, Mets is the energy consumption in physical activity divided by the energy consumption in the sitting resting state, and the sitting resting state is expressed by 1 Met (for example, the energy in the sitting resting state of a human with a body weight of 60 kg). Consumption is 1 Mets × 1 hour × 60 kg body weight = 60 kcal). According to the revised “Met of Physical Activity (METs)” (National Institute of Health and Nutrition, revised on April 11, 2012), energy consumption for slow jogging (code: 12010) is 6.0 mets. It is. Therefore, in the present invention, a subject who is exercising is subject to exercise with a momentum equivalent to or exceeding 6 Mets for a total of 3 hours per week (18 Met / week) or more (for example, 18 to 36 mets / week). As an exercise with a momentum equivalent to slow jogging (6.0 Mets), for example, running at about 6.4 km / hour (6.0 Mets, code: 12029) can be mentioned.

  In the present invention, the ingested or administered subject continuously exercises for a certain period (for example, at least 4 weeks, preferably at least 10 weeks) together with the combined intake or administration of the composition of the present invention and the milk protein-containing composition. The upper limit of the period is preferably not limited, and it is 20 weeks or 30 weeks if the upper limit is exemplified from the viewpoint of exercise continuity.

  The composition of the present invention can prevent and ameliorate anemia, and can suppress a decrease in muscle mass of an intake subject or administration subject (that is, maintain muscle mass). This effect can be more exerted by ingesting or administering the composition of the present invention to a subject who is exerting exercise load. Examples of muscles that can suppress the decrease include skeletal muscles. Specifically, it is possible to suppress a decrease in the muscle mass of the trunk and the muscle mass of both legs.

  The composition of the present invention can improve anemia, and the degree of improvement can be evaluated using the nutritional state associated with anemia as an index. Specifically, anemia occurs when the nutritional status associated with anemia after ingestion or administration of the compositions and milk protein-containing compositions of the present invention is better than the nutritional status associated with anemia prior to ingestion or administration. It can be determined that it has improved. Examples of blood nutritional status related to anemia that can serve as an indicator include somatomedin C (IGF-1) concentration, reticulocyte count, serum iron (Fe) content, hemoglobin (Hb) content, red blood cell count, erythropoietin concentration, IL -6 concentration, transferrin concentration, ferritin concentration, total iron binding ability (TIBC).

  When the blood concentration of somatomedin C is used as an indicator, the blood concentration of somatomedin C after the intake or administration of the composition of the present invention and the milk protein-containing composition is the blood concentration of somatomedin C before the intake or administration. Can be determined that anemia has improved (preferably, when the blood concentration of somatomedin C before ingestion or administration has increased by a factor of 1.1 or more). In addition, when the reticulocyte count in the blood was used as an index, the reticulocyte count after ingestion or administration of the composition of the present invention and the milk protein-containing composition increased from the reticulocyte count before ingestion or administration. In some cases (preferably, when the number of reticulocytes increases by 1.1 times or more before intake or administration), it can be determined that anemia has improved. That is, the composition of the present invention can be a composition for improving the nutritional state of iron in blood, and more specifically, a composition and network for increasing blood concentration of somatomedin C. It can be set as the composition for increasing a red blood cell count.

  The composition of the present invention can be provided as a composition comprising an intake or dose of a mineral component (and optionally a vitamin component) effective in preventing and ameliorating anemia. In this case, the composition of the present invention may be packaged so that a mineral component (and possibly a vitamin component) can be ingested in an effective intake or dose, as long as the effective intake or dose can be ingested. The form may be one package or a plurality of packages. Similarly, for milk protein-containing compositions used in combination with the composition of the present invention, as long as an effective intake or dose of milk protein for the prevention and improvement of anemia can be ingested or administered, the packaging form may be one package, Multiple packaging may be used.

  When the composition of the present invention and the milk protein-containing composition are provided in the form of a package, the description regarding the intake or dosage is made on the package so that the effective intake or dosage can be ingested or administered, or It is desirable to provide written documentation together. Moreover, when providing the effective intake or dose for one day with a plurality of packages, a plurality of packages for the effective intake or dose for one day can be provided as a set for convenience of intake.

  When the composition of the present invention and the milk protein-containing composition are provided in a package form, they can be provided in a unit package form for convenience of ingestion or administration, and are provided in a unit package form per serving. It is preferable. Here, “unit package form per meal” is a form in which the intake amount or dose per meal is determined in advance, for example, as a food or drink that can be orally ingested or administered a specific amount, Not only general foods but also beverages (including drinks), health supplements, health functional foods, supplements, and other forms are included.

  Even if the intake or dose per meal determined in advance in the unit package form is the effective intake or dose per day, the effective intake or dose per day is set twice or more (preferably May be taken in two or three times). Therefore, a mineral component (and possibly a vitamin component) can be blended in the above-mentioned daily intake or dosage for an adult in the unit package form of the composition of the present invention, or the above adult daily Mineral components (and vitamin components in some cases) can be blended in an amount that is one-half or one-third of the intake or dose of. Moreover, milk protein can be mix | blended with the intake or dosage per said adult in the unit packaging form of the milk protein containing composition used together with the composition of this invention, or said adult per day Milk protein can be blended in an amount that is one half or one third of the intake or dose of. The composition of the present invention and the milk-containing composition are in a “unit packaged form per meal” where the intake or dose per meal is the effective intake or dose per day for convenience of intake or administration. Preferably it is provided.

  The packaging form for providing the composition of the present invention is not particularly limited as long as it defines a certain amount. For example, packaging paper, bags, soft bags, paper containers, cans, bottles, capsules and the like can be accommodated. A container etc. are mentioned.

  The composition of the present invention is preferably ingested or administered continuously for 4 weeks or more together with the milk protein-containing composition in order to exert its effect more effectively, and the intake and administration period is more preferably 4 to 30 weeks, particularly preferably 10 to 20 weeks. As used herein, “continuously” means continuing to take or administer daily. When the composition of the present invention is provided in a packaged form, an effective intake or dose for a certain period (for example, one week) may be provided as a set for continuous intake or administration.

  According to the present invention, there is provided a method for preventing, treating or ameliorating anemia, which comprises ingesting or administering a mineral component-containing composition to a subject in combination with a milk protein-containing composition. The anemia prevention, treatment and amelioration methods of the present invention may be used in mammals including humans and are intended for both therapeutic and non-therapeutic uses. As used herein, “non-therapeutic” means not including the act of operating, treating, or diagnosing a human (that is, a medical act on a human), and specifically, receiving a doctor or doctor's instructions It means that the person does not include a method of performing surgery, treatment or diagnosis on humans. The method for preventing, treating and improving anemia of the present invention can be carried out according to the description of the composition of the present invention.

  The present invention will be described more specifically based on the following examples, but the present invention is not limited to these examples.

Example 1: Effects of vitamins, trace elements and milk protein on anemia (1) Test method Healthy female college students at risk of anemia were selected as test subjects. Thirty subjects were divided into three groups of 10 people. Table 1 shows the average values of the physique of each group at the start of the test.

  As test foods, vitamin / trace element enriched drinks and milk protein enriched drinks were used. The vitamin / trace element enriched beverage used in this example is a nutritional functional food (Maybalance (trade name) VitaZcs Vitajix, Meiji Co., Ltd.) containing trace elements such as iron, zinc, copper and selenium and 11 types of vitamins. Manufactured) (125 mL / book). Moreover, the milk protein enriched drink used in the present Example is a milk drink (Zavas (trade name) milk, manufactured by Meiji Co., Ltd.) (200 mL / book) containing 10.0 g of milk protein. The raw material names and nutritional components of these beverages are shown in Table 2.

  Analyzing 26 subjects excluding 4 subjects excluded from analysis, taking vitamin / trace element-enriched drinks, making group “I” (9 people) not exercising, and taking vitamin / trace element-enriched drinks The group that exercised was “Group II” (9 people), the group that ingested vitamin / trace element-enriched beverages, exercised, and further ingested milk protein-enriched beverages was “Group III” (8 people) ) Was evaluated by a parallel group comparison test.

  Exercise is slow jogging. Specifically, “Run at a slow speed for 1 minute and continue walking fast for 30 seconds for 15 minutes” as one set, 12 sets per week (180 minutes / week) ) In each group, the intake of the test food was 125 mL of the vitamin / trace element-enriched beverage and 200 mL of the milk protein-enriched beverage once a day for 12 weeks. The vitamin / trace element enriched beverage was ingested once a day at any time in Group I, Group II and Group III. The milk protein enriched drink was ingested at an arbitrary timing once a day in the group III.

  Blood was collected from the subjects on the ingestion start date (at the start of the study) and 12 weeks after the ingestion (at the end of the study). , 44 (4) pp. 383-391 (1996)), and the reticulocyte count was measured by flow-sentry method and microscopic method using a semiconductor laser. Masamitsu Kanai), pages 265-295, 2005). In addition, the subject's skeletal muscle mass, trunk muscle mass, right leg muscle mass, and left leg muscle mass were measured using the BIA method (bioelectrical impedance analysis, at the start of the test) and 12 weeks after the intake (at the end of the test). Impedance method) was measured using InBody430 (manufactured by Inbody Japan).

(2) Test results Table 3 shows the measurement results for somatomedin C (IGF-1) concentration and reticulocyte count.

  From the results shown in Table 3, in group III where vitamin / trace element-enriched beverage was administered and exercise was performed, and milk protein-enriched beverage was administered, somatomedin C concentration and reticulocyte count at the end of the test were compared with those at the start of the test. It was confirmed that it increased. On the other hand, in Group I and Group II, it was confirmed that the somatomedin C concentration at the end of the test was maintained or slightly increased compared to the start of the test, and the reticulocyte count was slightly decreasing.

Tables 4 and 5 show the measurement results for skeletal muscle mass, trunk muscle mass, right leg muscle mass, and left leg muscle mass.

From the results of Table 4 and Table 5, in group III where vitamin / trace element enriched beverage was administered and exercise was performed, and milk protein enriched beverage was administered, skeletal muscle mass, trunk muscle mass, right It was confirmed that the leg muscle mass and the left leg muscle mass were maintained at least as compared with those at the start of the test. On the other hand, in Group I and Group II, it was confirmed that the skeletal muscle mass, trunk muscle mass, right leg muscle mass, and left leg muscle mass at the end of the study were in a decreasing trend compared to the beginning of the study.

Claims (15)

  A composition for preventing or ameliorating anemia, comprising a mineral component as an active ingredient, which is ingested in combination with a milk protein-containing composition.   The composition of claim 1 further comprising a vitamin component.   The composition according to claim 1 or 2, wherein the mineral component is at least one selected from the group consisting of iron, sodium, potassium, calcium, magnesium, phosphorus, chlorine, zinc, copper and selenium.   The vitamin component is at least one selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, folic acid, pantothenic acid and biotin. Item 4. The composition according to Item 2 or 3.   The composition according to any one of claims 1 to 4, which is ingested by an exercised subject.   The composition according to any one of claims 1 to 5, which is taken by a woman at risk for anemia.   The composition according to any one of claims 1 to 6, which suppresses a decrease in muscle mass.   The composition according to any one of claims 1 to 7, for increasing blood concentration of somatomedin C (IGF-1).   The composition according to any one of claims 1 to 8, for increasing the reticulocyte count.   The composition as described in any one of Claims 1-9 which is a unit packaging form.   The composition as described in any one of Claims 1-10 which contains 0.1-4.0g as a daily intake of a mineral component.   The composition according to any one of claims 1 to 11, wherein the milk protein-containing composition is in a unit package form.   The composition according to any one of claims 1 to 12, wherein the milk protein-containing composition comprises 1 to 100 g of milk protein as a daily intake.   The composition according to any one of claims 1 to 13, which is a food composition. A method for preventing or ameliorating anemia comprising excluding or administering a mineral component-containing composition to a subject in combination with a milk protein-containing composition (except for medical practice for humans).