JP2018188368A - Wet wiper - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a wet wiper impregnated with a chemical solution containing a minimum amount of ethanol, which exhibits excellent sterilization performance. The present invention is a wet wiper in which a non-woven fabric is impregnated with a chemical solution, wherein the chemical solution contains quaternary ammonium salts, propynyl iodide butylcarbamate, and polyaminopropyl biguanide, and substantially contains ethanol. A wet wiper, which is an aqueous solution containing no mixture, is provided. According to the wet wiper of the present invention, stains containing proteins can be wiped cleanly, and sufficient sterilization performance can be exhibited even if ethanol is not substantially contained. [Selection diagram] None

Description

  The present invention relates to a wet wiper substantially free of ethanol.

  The wet wiper is generally used for removing dirt and germs on fingers and cleaning various instruments, and tends to be handled with bare hands. As a conventionally known wet wiper, for example, a wet wiper impregnated with a chemical solution containing paraoxybenzoic acid ester, ethanol, propylene glycol and the like is known (for example, see Patent Document 1).

  Here, a wet wiper impregnated with a chemical solution containing ethanol is known for the purpose of sterilization of the environment in a hospital, a table, a bed, and the like. Ethanol is known as a disinfectant that is effective against general live bacteria (gram-positive and gram-negative bacteria), tuberculosis bacteria, fungi, viruses, etc., and is highly safe for the human body. It is widely used as a disinfectant to be removed.

Japanese Patent Laid-Open No. 02-061000

  However, since ethanol has a function of coagulating dirt containing protein such as blood, it is difficult to clean and sterilize dirt containing protein with a wet wiper impregnated with a chemical solution containing ethanol. . On the other hand, when ethanol is not added to the chemical solution, there is a problem that the sterilization performance of the wet wiper impregnated with the chemical solution is insufficient. Accordingly, the present invention has been made in view of the above problems, and provides a wet wiper impregnated with a chemical solution with a minimum amount of ethanol blended and exhibiting excellent sterilization performance. The purpose is to do.

  The inventors of the present invention have conducted extensive research in view of the above problems. As a result, it has been found that a wet wiper containing a quaternary ammonium salt, propynyl iodide butylcarbamate, and polyaminopropyl biguanide and impregnated with an aqueous solution substantially free of ethanol can solve the above problems. The present invention has been completed. Specifically, the present invention provides the following.

  (1) A first aspect of the present invention is a wet wiper obtained by impregnating a nonwoven fabric with a chemical solution, wherein the chemical solution contains quaternary ammonium salts, propynyl butylcarbamate iodide, and polyaminopropyl biguanide, It is a wet wiper that is an aqueous solution that does not contain ethanol.

  (2) The second aspect of the present invention is the wet wiper according to (1), wherein the ethanol concentration in the chemical solution is less than 0.10% by mass.

  (3) A third aspect of the present invention is the wet wiper according to (1) or (2), wherein the quaternary ammonium salt is benzalkonium chloride.

  (4) A fourth aspect of the present invention is the wet wiper according to any one of (1) to (3), wherein the chemical solution includes a nonionic surfactant, and an anionic surfactant as the surfactant. It does not contain an agent.

  (5) A fifth aspect of the present invention is the wet wiper according to any one of (1) to (4), in which the chemical solution further includes benzoic acid, benzoates, chlorcresol, chlorobutanol, Salicylic acid, salicylic acid salts, sorbic acid, sorbic acid salts, dehydroacetic acid, dehydroacetic acid salts, trichlorohydroxydiphenyl ether, p-hydroxybenzoic acid ester, p-hydroxybenzoic acid sodium salt, phenoxyethanol, phenol, sodium lauryldiaminoethylglycine, resorcin, pantothenyl benzoate Ethyl ether, isopropylmethylphenol, cetylpyridinium chloride, chlorhexidine hydrochloride, orthophenylphenol, chlorhexidine gluconate, chlorxylenol, chlorhexidine, alkyl bromide Quinolinium, is to thymol, trichlorocarbanilide, halocarban, hinokitiol, characterized in that it contains at least one antimicrobial agent selected from the group consisting of zinc pyrithione, and silver ion antimicrobial agents.

  (6) A sixth aspect of the present invention is the wet wiper according to any one of (1) to (5), wherein a chemical solution of 25 parts by mass or more and 35 parts by mass or less is 10 parts by mass of the nonwoven fabric. It is impregnated.

  In the wet wiper of the present invention, since the chemical solution is an aqueous solution substantially free of ethanol, it is possible to clean away dirt containing protein. Further, the wet wiper of the present invention contains a quaternary ammonium salt, propynyl butyl carbamate, and polyaminopropyl biguanide, so that it can be sufficiently sterilized even if it does not substantially contain ethanol. Performance can be demonstrated.

  Hereinafter, embodiments for carrying out the present invention will be described in detail.

<Wet wiper>
The wet wiper of the present invention is a nonwoven fabric impregnated with a predetermined chemical solution.

[Nonwoven fabric]
Nonwoven fabrics include wood pulp fibers, regenerated fibers such as rayon, natural fibers such as cotton, synthetic fibers such as polyethylene, polypropylene, polyethylene terephthalate, chemical bond method, spunlace method, spunbond method, needle punch method, airlaid method In addition, those integrated by a known processing method such as a wet spunlace method or a melt bond method can be used. What is necessary is just to select suitably the ratio of each fiber used for a nonwoven fabric, and each processing method for unifying a nonwoven fabric according to the texture and mechanical strength which are requested | required of a wet wiper.

The wet wiper can also be provided as a roll body, but when manufacturing the wet wiper roll body, the nonwoven fabric is perforated at regular intervals perpendicular to the winding direction, and the nonwoven fabric is rolled. It is preferable to wind in the shape. The nonwoven fabric sheet may be folded in two or more by a fold line parallel to the length direction, and may not be folded. The total width of the nonwoven fabric sheet is preferably 90 mm or more and 400 mm or less, and is parallel to the length direction. The folding width when folding with a simple fold line is preferably 45 mm or more and 200 mm or less, the winding length of the nonwoven fabric is preferably 8 m or more and 100 m or less, and the basis weight of the nonwoven fabric is 20 g / m ² or more. It is preferable that it is 50 g / m ² or less. By setting the winding length and folding width of the nonwoven fabric within the above ranges, the wet wiper has a convenient size. Moreover, by setting the basis weight within the above range, the wet wiper has both an appropriate texture and strength.

  The wet wiper may be a single wafer as found in handy wet tissue. In that case, as for the dimension per wet wiper, the dimension in the length direction is preferably 140 mm or more and 400 mm or less, and the dimension in the width direction is preferably 140 mm or more and 400 mm or less. It is preferable that the wet wipers can be taken out one by one in a pop-up form, and the wet wipers stacked on the top and bottom are Z-folded or V-folded, and are stacked on each other. preferable.

[Medical solution]
In producing the wet wiper, the chemical solution impregnated into the nonwoven fabric is an aqueous solution containing at least quaternary ammonium salts, propynyl butylcarbamate iodide, and polyaminopropyl biguanide. By including these three kinds of components, even when ethanol is not substantially contained in the aqueous solution that is a chemical solution impregnated in the wet wiper, the wet wiper has excellent sterilization performance.

  The nonwoven fabric is preferably impregnated with 25 to 35 parts by mass of a chemical solution, more preferably 28 to 32 parts by mass with respect to 10 parts by mass of the nonwoven fabric. By setting the amount of the chemical within the above range, when removing dirt from fingers and various devices, the chemical does not become excessive and does not remain, and the nonwoven fabric has sufficient sterilization and antiseptic effects. In addition, it is possible to sufficiently remove dirt and germs with a small number of wiping operations.

(Quaternary ammonium salts)
The quaternary ammonium salt that can be blended in the chemical solution impregnated in the wet wiper of the present invention is not particularly limited as long as it is a quaternary ammonium salt having sterilizing performance, and is not particularly limited. Stearyltrimethylammonium, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, and the like can be mentioned. In the present invention, benzalkonium chloride is preferably used as the quaternary ammonium salt. This benzalkonium chloride is a drug mainly having an effect as a bactericidal agent against bacteria. The content of benzalkonium chloride in the chemical solution is preferably 0.001% by mass to 0.05% by mass, and more preferably 0.01% by mass to 0.05% by mass. By making the content of benzalkonium chloride within the above range, while suppressing the production cost to an appropriate range, it suppresses irritation to the skin, without causing a feeling of use such as stickiness or sliminess, The bactericidal and antifungal effects can be maintained well.

(Propynyl iodide butylcarbamate)
Propynyl iodobutylcarbamate is a drug that exerts an effect as a preservative mainly against fungi. The content of propynyl butylcarbamate in the chemical solution is preferably 0.001% by mass or more and 0.02% by mass or less, and more preferably 0.005% by mass or more and 0.02% by mass or less. The content of propynyl butylcarbamate iodide is within the above range, so that the production cost is kept within an appropriate range, and the occurrence of odor peculiar to propynyl iodide butylcarbamate is suppressed, and the bactericidal effect In addition, the antifungal effect can be maintained satisfactorily.

(Polyaminopropyl biguanide)
Polyaminopropyl biguanide is a drug that exhibits an effect as a preservative against various bacteria. The content of polyaminopropyl biguanide in the chemical solution is preferably 0.01% by mass or more and 0.1% by mass or less, and more preferably 0.05% by mass or more and 0.1% by mass or less. When the content of the polyaminopropyl biguanide is within the above range, the production cost can be suppressed to an appropriate range, and the bactericidal effect can be favorably maintained.

(ethanol)
The chemical liquid impregnated in the wet wiper of the present invention is an aqueous solution substantially free of ethanol, the ethanol concentration in the chemical liquid is preferably less than 0.10% by mass, more preferably less than 500 ppm, More preferably, it is 0%. Since the chemical liquid to be impregnated into the wet wiper does not substantially contain ethanol, ethanol in the chemical liquid has no possibility of coagulating protein dirt, and thus protein dirt such as blood can be suitably wiped off.

(Nonionic surfactant)
The chemical liquid impregnated in the wet wiper of the present invention preferably further contains a nonionic surfactant. Nonionic surfactants include polyoxyethylene alkyl ether, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene fatty acid ester, polyhydric alcohol fatty acid ester, polyoxyethylene alkyl ether Oxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene fatty acid amide, sorbitan mono fatty acid ester, sorbitan di fatty acid ester, sorbitan tri fatty acid ester, polyoxyethylene sorbitan mono fatty acid ester, polyoxyethylene sorbitan di fatty acid ester, polyoxyethylene sorbitan tri Fatty acid ester, polyoxyethylene sorbitol fatty acid ester, glycerin fatty acid ester, sucrose fatty acid ester Ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl amine, polyoxyethylene fatty acid amides. These nonionic surfactants may be used alone or in combination of two or more. The chemical liquid impregnated in the wet wiper of the present invention preferably contains polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene cetyl ether, and glycerin fatty acid ester among these nonionic surfactants.

  When the chemical liquid impregnated in the wet wiper of the present invention contains a nonionic surfactant, it is difficult to foam during wiping, and it does not impair the usability of the wet wiper, but general oil and fat stains can be easily wiped off. The content of the nonionic surfactant in the chemical solution is preferably 0.1% by mass or more and 1.0% by mass or less, and more preferably 0.2% by mass or more and 0.8% by mass or less.

(Anionic surfactant)
In addition, when an anionic surfactant is added to the chemical liquid to be impregnated into the wet wiper of the present invention, it is preferable that the chemical liquid does not contain an anionic surfactant because bubbles are easily generated during wiping and the feeling of use is reduced. .

(Other antibacterial agents)
It is preferable that the chemical | medical solution impregnated to the wet wiper of this invention contains various antibacterial agents other than each component demonstrated above. By including an additional antibacterial agent in the chemical solution, the long-term storage stability of the wet wiper is improved. Examples of such antibacterial agents include, but are not limited to, benzoic acid, benzoates, chlorcresol, chlorobutanol, salicylic acid, salicylates, sorbic acid, sorbic acid salts, dehydroacetic acid, dehydroacetates, trichloro Hydroxydiphenyl ether, p-hydroxybenzoate, p-oxybenzoic acid sodium salt, phenoxyethanol, phenol, sodium lauryldiaminoethylglycine, resorcin, benzoic acid pantothenylethyl ether, isopropylmethylphenol, cetylpyridinium chloride, chlorhexidine hydrochloride, orthophenylphenol, gluconic acid Chlorhexidine, chlorxylenol, chlorhexidine, alkylisoquinolinium bromide, thymol, trichlorocarbanilide, ha Calvin, mention may be made of hinokitiol, zinc pyrithione, and that at least one antimicrobial agent selected from the group consisting of silver ion antimicrobial agents. Among these, it is particularly preferable to use silver ion antibacterial agents, paraoxybenzoic acid esters, benzoates, and sorbates.

  Hereinafter, the present invention will be described in detail with reference to examples. In addition, this invention is not limited to the Example shown below at all.

<Examples 1 to 5, Comparative Examples 1 to 7>
According to the formulation shown in Table 1, 0.05 parts by mass of benzalkonium chloride, 0.02 parts by mass of propynyl butylcarbamate iodide, 0.1 parts by mass of polyaminopropyl biguanide, 100 parts by mass, based on 100 parts by mass of water 0.5 part by mass of a surfactant, 0.5 part by mass of an anionic surfactant, 0.02 part by mass of a water-soluble silver compound as a silver ion antibacterial agent, and 80 parts by mass of ethanol were appropriately added. The obtained chemical solution is impregnated into the nonwoven fabric at the impregnation rate shown in Table 1, easy removal of oil stains, easy removal of protein stains, effects on fungi, effects on gram-negative bacteria, effects on viruses, The ease of foaming, the ease of wiping off, and the remaining liquid were evaluated according to the following criteria.

(Ease of oil stains)
300 μL of castor oil was dropped onto a stainless steel plate and spread in a circle with a diameter of 30 mm to obtain a simulated oil stain. A wrap was wound around a melamine sponge having a bottom surface of 60 mm × 60 mm, and a wet wiper was wound on the outer layer in a single layer, and a load of 20.8 gf / cm ² was applied using a weight, and then wiped once. The oil stain after wiping was evaluated according to the following criteria.
○: Good dirt removal △: Somewhat bad dirt removal ×: Bad dirt removal

(Easy to remove protein stains)
300 μL of equine blood was dropped onto a stainless steel plate, spread in a circle with a diameter of 30 mm, dried at 50 ° C. for 5 minutes, and then the stainless steel plate was sufficiently dissipated to give a simulated protein stain. A wrap was wound around a melamine sponge having a bottom surface of 60 mm × 60 mm, and a wet wiper was wound around the outer layer in a single layer, and a load of 20.8 gf / cm ² was applied using a weight to wipe it in one direction. About the wiping off, in order to eliminate the difference by the cloth direction of a nonwoven fabric, it rotated rotating 90 degree every time it wiped off once.
○: Number of wipes 10 times or less △: Number of wipes 10 to 20 times ×: Number of wipes 20 times or more

(Effect on fungi)
The test bacteria Aspergillus niger was cultured in a potato dextrose agar medium, and then suspended in purified water to adjust the number of bacteria to a predetermined number to obtain a test bacterial solution. After squeezing the wet wiper to adjust the squeezed solution, inoculate 0.1 mL of a predetermined bacterial cell as a test bacterial solution into 10 mL of the solution, and let it act for a predetermined time from 30 seconds to 10 minutes at room temperature. The number of bacteria was measured using a dilution plate culture method (25 ° C., 5 days) on an SCDLP agar medium.

(Effect on Gram-positive and Gram-negative bacteria)
The test bacteria Escherichia coli and Pseudomonas aeruginosa are each cultured in a normal agar medium, then suspended in sterile physiological saline and adjusted so that the number of bacteria is about 10 ⁸ cells / mL, and used as a test bacterial solution. The squeezed solution was adjusted by squeezing the wet wiper, and 0.2 mL of Escherichia coli cells was ingested into 19.8 mL of the solution as a test microbial solution and allowed to act at 25 ° C. for 30 seconds to 10 minutes. Thereafter, 1 g of the solution was diluted with 9 mL of LP diluent. This was serially diluted and the viable cell count was measured using a pour plate culture method (30 ° C., 3 days) on an SCDLP agar medium.

(Effectiveness against viruses)
Test virus suspensions of feline calicivirus (F-9) and influenza A virus (H1N1) were prepared. To 10 mL of the test sample, 0.1 mL of the test virus suspension was added and left at 25 ° C. for 5 minutes. 0.5 mL of the mixture after standing was added to 4.5 mL of an inactivating agent (SXDLP medium) and mixed. The virus infectivity titer is measured by the plaque measurement method. When the infectious titre reduction rate is 99% or more, ◯, when the infectious titre reduction rate is 50% or more and less than 99%, Δ, when the infectious titre reduction rate is less than 50% It was.

(Ease of foaming)
A sensory evaluation was conducted on the ease of foaming of 30 panelists. In this evaluation, as a result of observation by visual observation, a sensory test was performed to select one of the evaluations with no foaming, slightly more, or more. The case where the evaluation of no foaming was 24 to 30 was rated as ◯, the case where the evaluation of no foaming was from 16 to 23 was evaluated as Δ, and the case where the evaluation of no foaming was from 0 to 15 was evaluated as ×.

(Ease of wiping)
A sensory evaluation was conducted on the ease of wiping the panel of 30 nursing staff. In this evaluation, a sensory test was performed to select one of the evaluations that are easy to wipe off, slightly difficult to wipe off, or difficult to wipe off. When the evaluation of easy wiping is from 24 to 30 people, ◯, when easy evaluation is from 16 to 23 people, Δ, and when easy evaluation is from 0 to 15 people, the evaluation is ×.

(Liquid remaining)
A sensory evaluation was conducted on the remaining liquid for 30 panelists. In this evaluation, a sensory test was performed to select one of the evaluations of no or little liquid residue, a little liquid residue, and a lot of liquid residue. ◯ when there is no or little liquid residue evaluation from 24 to 30 people, △ when there is no liquid remaining or little evaluation from 16 to 23 people, and evaluation from 0 to no or little liquid residue The case of 15 people was set as x.

<Evaluation results>
As is clear from the examples and comparative examples, the wet wiper of the example substantially impregnated with ethanol and impregnated with a chemical solution containing a quaternary ammonium salt, propynyl iodide butylcarbamate, polyaminopropyl biguanide, In addition to effectively removing protein stains, the antibacterial performance was exhibited.

Claims (6)

A wet wiper in which a nonwoven fabric is impregnated with a chemical solution,
The wet wiper, wherein the chemical solution is an aqueous solution containing a quaternary ammonium salt, propynyl iodide butylcarbamate, and polyaminopropyl biguanide and substantially free of ethanol.   The wet wiper according to claim 1, wherein the concentration of ethanol in the chemical solution is less than 0.10% by mass.   The wet wiper according to claim 1 or 2, wherein the quaternary ammonium salt is benzalkonium chloride.   The wet wiper according to any one of claims 1 to 3, wherein the chemical liquid contains a nonionic surfactant and does not contain an anionic surfactant as a surfactant.   The chemical solution is further benzoic acid, benzoates, chlorcresol, chlorobutanol, salicylic acid, salicylic acid salts, sorbic acid, sorbic acid salts, dehydroacetic acid, dehydroacetic acid salts, trichlorohydroxydiphenyl ether, paraoxybenzoic acid ester, paraoxybenzoic acid Sodium salt, phenoxyethanol, phenol, sodium lauryldiaminoethylglycine, resorcin, benzoic acid pantothenyl ethyl ether, isopropylmethylphenol, cetylpyridinium chloride, chlorhexidine hydrochloride, orthophenylphenol, chlorhexidine gluconate, chlorxylenol, chlorhexidine, alkyl isobromide Quinolinium, thymol, trichlorocarbanilide, halocarban, hinokitiol, pyrithio Zinc, and containing at least one antimicrobial agent selected from the group consisting of silver ion antimicrobial agents, wipes according to any one of claims 1 to 4.   The wet wiper according to any one of claims 1 to 5, wherein a chemical solution of 25 parts by mass or more and 35 parts by mass or less is impregnated with respect to 10 parts by mass of the nonwoven fabric.