JP2015066104A - Alveolar bone regeneration induction membrane - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an alveolar bone regeneration guiding membrane excellent in handleability.SOLUTION: An alveolar bone regeneration guiding membrane 1A comprises multiple through-holes 2 having extracellular fluid permeability and cellular tissue impermeability and is made of metallic foil having shape retaining properties and biocompatibility. At least one of both side edges of the alveolar bone regeneration guiding membrane 1A includes: a first side edge 51 that is located on a side of one end 5a thereof; a second side edge 52 that is located outside more than the first side edge 51 and is located on a side of another end 5b; and a third side edge 53 that is located between the first side edge 51 and the second side edge 52 and is inclined outward as it approaches the second side edge 52 from the first side edge 51.

Description

  The present invention relates to an alveolar bone regeneration-inducing membrane suitable for bone regeneration induction therapy.

  Guided bone regeneration method (hereinafter sometimes referred to as “GBR method”) is a treatment method that promotes bone regeneration. Often used together in cases where bone mass is insufficient. In the GBR method, in order to suppress living tissue other than bone tissue such as gums from entering the bone defect region, a specific film covering the bone defect region is usually used.

  The present applicant has previously developed a membrane (support) described in Patent Document 1 as a membrane suitable for the GBR method. In use, this film had to be cut into an appropriate size and processed into a desired shape. In order to perform the GBR method smoothly, it is desirable that the film has excellent handleability.

JP 2011-212209 A

  An object of the present invention is to provide an alveolar bone regeneration-inducing membrane that is excellent in handleability.

As a result of intensive studies to solve the above-mentioned problems, the present inventors have found a solution means having the following constitution and have completed the present invention.
(1) An alveolar bone regeneration-inducing membrane comprising a plurality of through-holes having extracellular fluid permeability and cell tissue impermeability, and comprising a metal foil having shape retention and biocompatibility, wherein the alveolar bone regeneration At least one of both side edges of the guiding film is located on the first side edge located on the one end side, and on the other end side outside the first side edge. It is located between the second side edge, the first side edge and the second side edge, and inclines outward as it approaches the second side edge from the first side edge. And an alveolar bone regeneration-inducing membrane.
(2) At least one of the both side edges further includes a fourth side edge that is connected to each of the first side edge and the third side edge and has an inwardly convex curved shape. The membrane for inducing alveolar bone regeneration according to (1) above.
(3) At least one of the both side edges further includes a fifth side edge that is connected to each of the second side edge and the third side edge and has an outwardly convex curved shape. The membrane for inducing alveolar bone regeneration according to (1) or (2).
(4) When the distance between the side edges on the first side edge side is W1, and the distance between the side edges on the second side edge side is W2, W1 and W2 are W1 The alveolar bone regeneration-inducing membrane according to any one of (1) to (3), which has a relationship of <W2.
(5) The alveolar bone regeneration-inducing membrane according to any one of (1) to (4), further comprising a slit extending from one side to the other of both end edges of the alveolar bone regeneration-inducing membrane. .
(6) The alveolar bone regeneration-inducing membrane according to (5), wherein the slit has a width that decreases with increasing distance from the one of the both edge portions.
(7) The alveolar bone regeneration-inducing membrane according to (5) or (6), wherein the slit extends along the one perpendicular bisector of the both end edges that are substantially straight.
(8) The alveolar bone regeneration-inducing membrane according to any one of (1) to (7), further including an auxiliary membrane that protrudes outward from the vicinity of the one end of at least one of the side edges.
(9) The apparatus further comprises at least one of an inner frame extending inward of the alveolar bone regeneration-inducing membrane and an edge frame extending along a peripheral edge of the alveolar bone regeneration-inducing membrane. ) To (8) Alveolar bone regeneration-inducing membrane.
(10) The alveolar bone regeneration-inducing membrane according to (9), wherein the plurality of through-holes have a diameter that decreases toward at least one of the inner frame and the edge frame.
(11) The alveolar bone regeneration-inducing membrane according to (9) or (10), wherein when the inner frame and the edge frame are provided, the inner frame is continuous with the edge frame.
(12) The alveolar bone regeneration-inducing membrane according to any one of (1) to (11), further comprising at least one fixing member insertion hole located in the vicinity of a peripheral edge of the alveolar bone regeneration-inducing membrane. .
(13) The apparatus according to (12), further including an edge frame extending along a peripheral edge of the alveolar bone regeneration-inducing film, wherein the at least one fixing member insertion hole is located in the edge frame. Membrane for inducing alveolar bone regeneration.
(14) Both end edges of the alveolar bone regeneration-inducing membrane are substantially linear, and are substantially bilaterally symmetrical with respect to a straight line passing through the midpoint of each of the both end edges, The membrane for alveolar bone regeneration induction according to any one of (13) to (13).
(15) The alveolar bone regeneration-inducing membrane according to any one of (1) to (14), wherein the membrane is for anterior tooth defect of the upper and lower jaws.

  According to the present invention, since it is configured in a specific shape in advance, there is no need for processing in use, or simple processing is required, so that it is excellent in handling and can perform the GBR method smoothly. There is an effect that can be done.

It is a top view which shows the alveolar bone regeneration induction film | membrane which concerns on 1st Embodiment of this invention. It is a top view which shows the film | membrane for alveolar bone regeneration induction which concerns on 2nd Embodiment of this invention. It is a top view which shows the film | membrane for alveolar bone regeneration induction which concerns on 3rd Embodiment of this invention. (A) And (b) is a schematic explanatory drawing which shows the dental implant implantation operation which concerns on one Embodiment of this invention.

<Alveolar bone regeneration induction membrane>
(First embodiment)
Hereinafter, the alveolar bone regeneration-inducing membrane (hereinafter sometimes referred to as “membrane”) according to the first embodiment of the present invention will be described in detail with reference to FIG.

  As shown in FIG. 1, the film 1 </ b> A of this embodiment includes a plurality of through holes 2. The plurality of through holes 2 of the present embodiment penetrate between the front surface 3 and the back surface 4 of the film 1A as shown in FIG.

  The plurality of through holes 2 of the present embodiment have extracellular fluid permeability and cellular tissue impermeability. Extracellular fluid means body fluid. Examples of the body fluid include blood and lymph. The cell tissue is a living tissue composed of a plurality of cells and an extracellular matrix, and means soft tissue and hard tissue. Examples of the soft tissue include gingival tissue, skin tissue, adipose tissue, muscle tissue, blood vessel and the like. Examples of the hard tissue include bone tissue.

  The plurality of through holes 2 of the present embodiment preferably have a diameter of 0.1 to 500 μm, and more preferably 10 to 200 μm. Thereby, the some through-hole 2 comes to have the extracellular fluid permeability | transmittance and cellular tissue impermeability which were mentioned above.

  The membrane 1A of the present embodiment including the above-described through hole 2 is made of a metal foil having shape retention and biocompatibility. As shown in FIG. 4, the shape retaining property means a property capable of retaining the shape when the film 1 </ b> A is bent or bent. In other words, shape retention means the property that enables formation of an alveolar bone regeneration induction space, that is, space making, by bending or bending the membrane 1A. In addition, biocompatibility means a property that is substantially harmless when in contact with a living tissue and is easily adapted to living tissue.

  Examples of the metal constituting the metal foil having such characteristics include pure titanium having a purity of 99% by mass or more, titanium alloy, stainless steel, cobalt-chromium alloy, cobalt-chromium-molybdenum alloy, tantalum, zirconium, gold, platinum. Of these metals, pure titanium is preferable. Moreover, it is preferable that the metal which comprises metal foil has a malleability.

The thickness of the metal foil, that is, the thickness of the film 1A is preferably 5 to 100 μm. Thereby, the film 1A can be easily bent or folded with fingers, and excellent handling properties can be exhibited.
In addition, the more detailed description of the metal foil which comprises the some through-hole 2 with which the film | membrane 1A is equipped, and the film | membrane 1A is described in the patent document 1 mentioned above.

  On the other hand, as shown in FIG. 1, the film 1A of the present embodiment is opposed to each other as one side edge portion 5 and the other side edge portion 6 that are located opposite to each other as both side edge portions, and as both edge portions. It further has one end edge 7 and the other end edge 8 positioned. In the present embodiment, in the surface view, the one side edge portion 5 and the other side edge portion 6 extend along the length direction of the film 1A indicated by the arrow A, and the one end edge portion 7 and the other end edge portion 8 are , Extending along the width direction of the film 1A indicated by the arrow B. The surface view means a state in which the film 1A is viewed from the surface 3 side.

  In the present embodiment, when viewed from the front, both the one end edge 7 and the other end edge 8 are substantially linear, and the film 1A has a midpoint M7 of the one end edge 7 and a midpoint of the other end edge 8. The straight line L1 passing through M8 is substantially symmetrical about the axis of symmetry. Therefore, in this embodiment, since each structure of the one side edge part 5 and the other side edge part 6 is mutually the same, unless the special description is required below, description about the one side edge part 5 is provided. It shall replace with description about the other side edge part 6.

  In the surface view, the one side edge portion 5 of the present embodiment includes a first side edge portion 51 located on the one end portion 5a side, an outer side than the first side edge portion 51, and the other end portion 5b side. Is located between the second side edge 52 and the first side edge 51 and the second side edge 52, and the outer side becomes closer to the second side edge 52 from the first side edge 51. And a third side edge portion 53 inclined toward the direction. According to such a configuration, the following excellent handling properties can be exhibited.

  That is, according to the above-described configuration, the first to third side edge portions 51 to 53 can wrap around the remaining tooth while avoiding the remaining tooth and cover the bone defect region 100 shown in FIG. 4 with the film 1A. . Moreover, when processing the one side edge part 5 according to the remaining tooth, the one side edge part 5 may be processed on the basis of the shape of the first to third side edge parts 51 to 53. Simple processing is enough. Further, as shown in FIG. 1, the region 521 corresponding to the second side edge portion 52 of the membrane 1 </ b> A is configured to have a shape that bulges outward and can be easily grasped by an instrument. The film 1 </ b> A can be easily held by, for example.

  In the present embodiment, the first to third side edge portions 51 to 53 are all substantially linear in surface view, and the first side edge portion 51 and the second side edge portion 52 are substantially parallel to each other. In addition, it is substantially parallel to the straight line L1 described above.

  Moreover, in this embodiment, the one end edge part 7 mentioned above is located in the 1st side edge part 51 side in surface view, and the other end edge part 8 is located in the 2nd side edge part 52 side. In the surface view, the one end edge portion 7 of the present embodiment is substantially orthogonal to the first side edge portion 51, and the intersecting portion 1a of the one end edge portion 7 and the first side edge portion 51 is an outwardly convex curve. It is chamfered into a shape. Similarly, in the surface view, the other end edge portion 8 of the present embodiment is substantially orthogonal to the second side edge portion 52, and the intersection portion 1b of the other end edge portion 8 and the second side edge portion 52 is outward. It is chamfered into a convex curve. Further, in the present embodiment, the length of the other end edge portion 8 is configured to be larger than the length of the one end edge portion 7 in the surface view.

  Incidentally, since the first side edge portion 51 is located inward of the film 1A than the second side edge portion 52, the first side edge portion 51 is a portion where it is easier to avoid the remaining tooth. In the present embodiment, since the length of the first side edge portion 51 is configured to be larger than the length of the second side edge portion 52 in the surface view, excellent avoidance performance is exerted on the remaining teeth. can do.

  Moreover, in this embodiment, while improving the avoidance property with respect to the remaining tooth, it has the following configurations from the viewpoint of suppressing the remaining tooth from being damaged when contacting the remaining tooth. That is, in the present embodiment, the first side edge portion 5 is connected to each of the first side edge portion 51 and the third side edge portion 53 in the surface view, and has a curved inwardly convex shape. It further has an edge 54. In the present embodiment, the first side edge portion 5 is connected to each of the second side edge portion 52 and the third side edge portion 53 in the surface view, and has a curved outward convex shape. It further has an edge 55. Note that the first side edge portion 51 and the third side edge portion 53 can be directly connected to each other, and the second side edge portion 52 and the third side edge portion 53 are also directly connected to each other depending on cases and the like. be able to.

  In the present embodiment, when the distance between both side edges on the first side edge 51 side is W1 and the distance between both side edges on the second side edge 52 side is W2 in the surface view, W1 and W2 are , W1 <W2. According to such a configuration, the bone defect region 100 can be reliably covered by the region between the side edges on the second side edge 52 side that is configured to be wide in the film 1A.

  On the other hand, in the surface view, the film 1 </ b> A of the present embodiment further includes a slit 9 extending from the other end edge 8 toward the one end edge 7. According to such a configuration, as shown in FIG. 4, when there is a small band 120 near the bone defect region 100, the bone defect region 100 can be covered with the membrane 1A while avoiding the small band 120 by the slit 9. it can. Therefore, it is preferable to use the membrane 1A of the present embodiment for the anterior tooth portion defect of the upper and lower jaws in order to increase the usefulness of the present embodiment. In addition, the slit 9 of this embodiment functions also as a site | part which avoids the location which becomes the disorder | damage | failure of the film | membrane 1A when covering not only the small band 120 mentioned above but the bone defect area | region 100. FIG.

  As shown in FIG. 1, the slit 9 of the present embodiment has the following configuration in the surface view. That is, the width W9 of the slit 9 of the present embodiment decreases as the distance from the other end edge 8 increases. Further, the slit 9 of the present embodiment has a tip 91 located in a region 521 corresponding to the second side edge 52. The slit 9 of the present embodiment extends along the vertical bisector L2 of the other end edge 8. In the present embodiment, the perpendicular bisector L2 of the other end edge 8 is on the same straight line as the straight line L1 passing through the midpoint M7 of the one end edge 7 and the midpoint M8 of the other end edge 8 described above. positioned.

  The film 1A of the present embodiment described above can be produced by, for example, appropriately combining masking and etching, or repeating them.

(Second Embodiment)
Next, the film | membrane which concerns on 2nd Embodiment of this invention is demonstrated in detail with reference to FIG. In FIG. 2, the same components as those in FIG. 1 described above may be denoted by the same reference numerals and description thereof may be omitted.

  As shown in FIG. 2, the present embodiment is different from the first embodiment described above in that an auxiliary membrane 10 and an inner frame 11 are further provided. Specifically, the membrane 1B of this embodiment further includes an auxiliary membrane 10 that protrudes outward from the vicinity of the one end portion 5a of the one side edge portion 5. According to such a configuration, when the bone defect region 100 is covered with the membrane 1B, the auxiliary membrane 10 can follow the surface shape of the alveolar bone 111 to fix the membrane 1B. As a result, the membrane 1B can be fixed. Can be improved (see FIG. 4B).

  In addition, in the surface view, the auxiliary film 10 of the present embodiment is configured in a substantially triangular shape, but is not limited to this. In the surface view, the auxiliary film 10 can be formed in a substantially rectangular shape, for example, as shown in FIG.

  The membrane 1B of the present embodiment further includes an inner frame 11 extending inwardly. The inner frame 11 is a part having greater rigidity than other parts. Specifically, the inner frame 11 does not have, for example, a plurality of through holes 2, or has a smaller number of through holes 2 than other parts other than the inner frame 11, or is less than other parts. It is a site | part comprised so that rigidity may become larger than another site | part by increasing thickness. The inner frame 11 of the present embodiment is configured such that the rigidity is greater than other parts by not having the plurality of through holes 2. When the membrane 1B further includes such an inner frame 11, the strength of the membrane 1B can be improved.

  The number of inner frames 11 may be one or plural. Further, in the front view, the inner frame 11 may be configured as follows. That is, the inner frame 11 may extend in a substantially linear shape or a curved shape. The inner frame 11 may include a substantially linear portion and a curved portion, or may be branched. The end of the inner frame 11 may be located inside the membrane 1B or may reach the peripheral edge 12 of the membrane 1B. When the number of the inner frames 11 is plural, the plurality of inner frames 11 may cross each other or may be located apart from each other.

The inner frame 11 provided in the membrane 1B of the present embodiment includes a first inner frame 11a located on the first side edge 51 side and a second side located on the second side edge 52 side. There are two inner frames 11b. In the present embodiment, the first and second inner frames 11a and 11b have the following configuration when viewed from the front. That is, both the first and second inner frames 11a and 11b are branched into a plurality and extend substantially linearly, and the end portions 11a1 and 11b1 reach the peripheral edge 12 of the membrane 1B. The first and second inner frames 11a and 11b are located away from each other.
Since other configurations are the same as those of the film 1A according to the first embodiment described above, the description thereof is omitted.

(Third embodiment)
Next, the film | membrane which concerns on 3rd Embodiment of this invention is demonstrated in detail with reference to FIG. In FIG. 3, the same components as those in FIGS. 1 and 2 described above may be denoted by the same reference numerals and description thereof may be omitted.

  As shown in FIG. 3, the present embodiment is different in configuration from the first and second embodiments described above in that it further includes an edge frame 13 and a fixing member insertion hole 14. More specifically, the membrane 1 </ b> C of the present embodiment further includes an edge frame 13 extending along the peripheral edge 12. According to such a configuration, the strength of the film 1 </ b> C can be improved similarly to the above-described inner frame 11.

  In the surface view, the edge frame 13 may extend continuously over the entire periphery of the peripheral edge portion 12 of the film 1C, or may extend intermittently. In the surface view, the edge frame 13 of the present embodiment continuously extends over the entire periphery of the peripheral edge portion 12 of the membrane 1C. Note that the other configuration of the edge frame 13 is the same as that of the inner frame 11, and thus the description thereof is omitted.

  When viewed from the front, the membrane 1 </ b> C of the present embodiment further includes a third inner frame 11 c that branches into three and extends substantially linearly as the inner frame 11. In the front view, in the present embodiment, the third inner frame 11 c is continuous with the edge frame 13. According to such a configuration, when the film 1C is bent or bent, the strength in the region between the third inner frame 11c and the edge frame 13 that is relatively easily loaded and easily damaged such as a crack is improved. Occurrence of damage can be suppressed.

  In front view, in the present embodiment, of the three end portions 11c1 to 11c3 of the third inner frame 11c, the end portion located on the one end edge 7 side that is relatively easily loaded and easily damaged. The third inner frame 11c continues to the edge frame 13 via 11c3. If necessary, the third inner frame 11c may be continuous with the edge frame 13 via the remaining two end portions 11c1 and 11c2.

  On the other hand, the plurality of through holes 2 described above preferably have a smaller diameter as they approach at least one of the third inner frame 11 c and the edge frame 13. According to such a configuration, since the region between the adjacent through holes 2 and 2 increases toward the third inner frame 11c and the edge frame 13, the vicinity of the third inner frame 11c and the edge frame The strength of the film 1 </ b> C in the vicinity of 13 is improved, and as a result, the effect of including the third inner frame 11 c and the edge frame 13 can be improved. From the same viewpoint, the number of through holes 2 may decrease as it approaches at least one of the third inner frame 11 c and the edge frame 13.

  The membrane 1 </ b> C of the present embodiment further includes at least one fixing member insertion hole 14 positioned in the vicinity of the peripheral edge portion 12. The fixing member insertion hole 14 penetrates between the front surface 3 and the back surface 4 of the film 1C and functions as a portion through which the fixing member is inserted. When the membrane 1C further includes such a fixing member insertion hole 14, when the bone defect region 100 is covered with the membrane 1C, the fixing member is inserted into the fixing member insertion hole 14 to fix the membrane 1C to the alveolar bone. Can do. Examples of the fixing member include a suture thread, a screw, a staple, and a nail.

  The number of the fixing member insertion holes 14 is not particularly limited as long as it is at least one, and a desired number can be adopted. The number of the fixing member insertion holes 14 in the present embodiment is four.

In the present embodiment, the four fixing member insertion holes 14 are all located in the edge frame 13 in the surface view. According to such a configuration, it is possible to reinforce the strength of the film 1 </ b> C that has been reduced by forming the fixing member insertion hole 14.
Since other configurations are the same as those of the films 1A and 1B according to the first and second embodiments described above, the description thereof is omitted.

<Dental implant implantation surgery>
Next, a dental implant implantation operation according to an embodiment of the present invention that uses the GBR method will be described in detail with reference to FIG. 4, taking as an example the case of using the film 1A according to the first embodiment described above. To do.

  First, a portion corresponding to the bone defect region 100 in the gingiva is incised to expose the bone defect region 100 in which a part of the alveolar bone 111 is lost in the jawbone 110. Next, the membrane 1A is curved or bent to cover the exposed bone defect region 100. At this time, the film 1A exhibits excellent handling properties for the reasons described above. Further, when several films having different sizes are prepared as the film 1A, even better handling properties can be exhibited.

  After a period of several months with the bone defect region 100 covered with the membrane 1A, the alveolar bone 111 is regenerated by filling the bone defect region 100 covered with the membrane 1A with bone tissue (GBR method). That is, in the bone defect region 100, a new alveolar bone 111 having substantially the same component as the alveolar bone 111 before the defect is formed.

  Finally, the gingiva is re-incised to remove the membrane 1A, the fixture is embedded and fixed in the alveolar bone 111, and after an unloading period of several weeks to several months, the abutment and artificial tooth are placed on the fixture Attach to dental implant and finish treatment.

  In the above-described embodiment, before the exposed bone defect region 100 is covered with the film 1A, the transplant material 130 can be filled into the bone defect region 100 as necessary. Examples of the transplant material 130 include autologous bone, artificial bone, bone filling material, bone morphogenetic protein, and platelet rich plasma. Examples of autologous bones include bones of patients collected from the jawbone, tibia, iliac bone, and the like. Examples of the artificial bone include β-TCP and hydroxyapatite. Examples of the bone filling material include collagen sponge. These exemplified graft materials 130 can be used alone or in combination of two or more.

  In the above-described embodiment, the fixture is embedded after the bone formation by the GBR method is completed. However, the bone formation by the GBR method can be performed simultaneously with the fixture insertion. That is, at the same time that the fixture is embedded in the alveolar bone 111, the bone 1D can be covered with the membrane 1A to perform bone formation.

  In the above-described embodiment, the case where the film 1A is used has been described as an example. However, the same effect can be obtained by using the films 1B and 1C instead of the film 1A.

  As mentioned above, although some embodiment which concerns on this invention was illustrated, this invention is not limited to embodiment mentioned above, It cannot be overemphasized that it can be made arbitrary, unless it deviates from the summary of this invention. .

  For example, in each of the above-described embodiments, the films 1A to 1C are configured to be substantially bilaterally symmetric, but instead, the films 1A to 1C can be configured to be bilaterally asymmetric. Specifically, for example, the positions of the first to third side edges 51 to 53 of the one side edge 5 and the first to first of the other side edge 6 so that the films 1A to 1C are left-right asymmetric. The position of the third side edge is shifted from each other, the other side edge 6 has no first to third side edges, and only one side edge 5 has the first to third side edges 51 to 53. It can be configured to have.

  In each of the embodiments described above, the slit 9 extends from the other end edge 8 toward the one end edge 7. Instead, the slit 9 extends from the one end edge 7 toward the other end edge 8. Can be configured to extend. That is, the slit 9 can extend from any one of the edge portions of the films 1A to 1C toward the other.

  In the above-described second and third embodiments, the inner frame 11 or the inner frame 11 and the edge frame 13 are provided. Instead, the structure includes only the edge frame 13. Can do.

1A to 1C Alveolar bone regeneration-inducing membrane 1a intersecting portion 1b intersecting portion 2 through-hole 3 surface 4 back surface 5 one side edge 5a one end 5b other end 51 first side edge 52 second side edge 521 region 53 first 3 side edge portion 54 4th side edge portion 55 5th side edge portion 6 other side edge portion 7 one end edge portion 8 other end edge portion 9 slit 91 tip portion 10 auxiliary film 11 inner frame 11a first inner frame 11a1 end Part 11b Second inner frame 11b1 End part 11c Third inner frame 11c1 to 11c3 End part 12 Peripheral part 13 Edge frame 14 Fixing member insertion hole 100 Bone defect region 110 Jaw bone 111 Alveolar bone 120 Small band 130 Implant

Claims (15)

An alveolar bone regeneration-inducing membrane comprising a plurality of through-holes having extracellular fluid permeability and cellular tissue impermeability, and comprising a metal foil having shape retention and biocompatibility,
At least one of both side edges of the alveolar bone regeneration-inducing membrane is a first side edge located on one end side, and on the other end side outward from the first side edge. The second side edge is positioned, and is located between the first side edge and the second side edge, and outwards from the first side edge toward the second side edge. An alveolar bone regeneration-inducing membrane having a third side edge portion inclined toward the front.   At least one of the both side edges further includes a fourth side edge that is connected to each of the first side edge and the third side edge and has an inwardly convex curved shape. 2. The alveolar bone regeneration-inducing membrane according to 1.   The at least one of the both side edges further includes a fifth side edge that is connected to each of the second side edge and the third side edge and has an outwardly convex curved shape. The membrane for inducing alveolar bone regeneration according to 1 or 2.   When the distance between the both side edges on the first side edge side is W1, and the distance between the both side edges on the second side edge side is W2, W1 and W2 satisfy W1 <W2. The membrane for inducing alveolar bone regeneration according to any one of claims 1 to 3, which has a relationship.   The alveolar bone regeneration-inducing membrane according to any one of claims 1 to 4, further comprising a slit extending from one end to the other of both edge portions of the alveolar bone regeneration-inducing membrane.   The alveolar bone regeneration-inducing membrane according to claim 5, wherein the slit has a width that decreases with increasing distance from the one of the both edge portions.   The alveolar bone regeneration-inducing membrane according to claim 5 or 6, wherein the slit extends along the one perpendicular bisector of the both end edges that are substantially straight.   The alveolar bone regeneration-inducing membrane according to any one of claims 1 to 7, further comprising an auxiliary membrane protruding outward from the vicinity of the one end of at least one of the side edges.   9. The apparatus according to claim 1, further comprising at least one of an inner frame extending inward of the alveolar bone regeneration-inducing membrane and an edge frame extending along a peripheral edge of the alveolar bone regeneration-inducing membrane. The alveolar bone regeneration-inducing membrane according to any one of the above.   The alveolar bone regeneration-inducing membrane according to claim 9, wherein the plurality of through-holes have a diameter that decreases toward at least one of the inner frame and the edge frame.   The alveolar bone regeneration-inducing membrane according to claim 9 or 10, wherein when the inner frame and the edge frame are provided, the inner frame is continuous with the edge frame.   The alveolar bone regeneration-inducing membrane according to any one of claims 1 to 11, further comprising at least one fixing member insertion hole located in the vicinity of a peripheral edge of the alveolar bone regeneration-inducing membrane. An edge frame extending along a peripheral edge of the alveolar bone regeneration-inducing membrane,
The alveolar bone regeneration-inducing membrane according to claim 12, wherein the at least one fixing member insertion hole is located in the edge frame. Both edge portions of the alveolar bone regeneration-inducing membrane are both substantially linear,
The alveolar bone regeneration-inducing membrane according to any one of claims 1 to 13, which is substantially bilaterally symmetric with respect to a straight line passing through the midpoint of each of the both edge portions.   The membrane for inducing alveolar bone regeneration according to any one of claims 1 to 14, wherein the membrane is for anterior tooth defect of upper and lower jaws.

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