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JP2014111664A5
JP2014111664A5 JP2014052426A JP2014052426A JP2014111664A5 JP 2014111664 A5 JP2014111664 A5 JP 2014111664A5 JP 2014052426 A JP2014052426 A JP 2014052426A JP 2014052426 A JP2014052426 A JP 2014052426A JP 2014111664 A5 JP2014111664 A5 JP 2014111664A5
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citrus
nobiletin
plant tissue
pharmaceutical product
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JP2014052426A
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JP5906267B2 (en
JP2014111664A (en
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乾燥植物組織１００重量％に対してノビレチンを０．３〜２．０重量％含有し、ナリルチンを０．４重量％以下含有し、タンゲレチンを０．１〜０．８重量％含有し、ヘスペリジンを０．４〜１２重量％含有し、ノビレチン／ナリルチンの含有重量比が１．０〜２３．０である柑橘類の乾燥植物組織と医薬的に許容される生薬成分とを１：５〜１：１０の重量比率で配合して得られる配合物から水抽出により得られる抽出物を含有する、学習・記憶障害における記憶の獲得能力の増強またはパーキンソン病におけるドーパミン合成能の促進、ドーパミン含量の上昇もしくはドーパミン分泌の促進のための医薬品であって、
柑橘類がシトラス・レチクラータ・ブランコ（ルタシー）、タチバナまたはオオベニミカンである、医薬品。 The nobiletin the dry plant tissue 100 wt% containing 0.3 to 2.0 wt%, containing 0.4 wt% or less Nariruchin, contain tangeretin 0.1-0.8 wt%, hesperidin A citrus dry plant tissue containing 0.4 to 12 % by weight and a nobiletin / nariltin weight ratio of 1.0 to 23.0 and a pharmaceutically acceptable herbal ingredient 1: 5 to 1:10 Containing an extract obtained by water extraction from a composition obtained by blending at a weight ratio of , enhancing the ability to acquire memory in learning / memory disorders or promoting the ability to synthesize dopamine in Parkinson's disease, increasing dopamine content or dopamine A pharmaceutical product for promoting secretion,
A pharmaceutical product wherein the citrus fruit is Citrus reticulata blanco (Lutacy), Tachibana or Giant orange. 柑橘類がタチバナまたはオオベニミカンである、請求項１記載の医薬品。   The pharmaceutical product according to claim 1, wherein the citrus fruit is Tachibana or Obenimikan. 記憶の獲得能力の増強のための、請求項１または２のいずれか記載の医薬品。   3. A pharmaceutical product according to claim 1 or 2 for enhancing the ability to acquire memory. ドーパミン合成能の促進、ドーパミン含量の上昇またはドーパミン分泌の促進のための、請求項１または２のいずれか記載の医薬品。   The pharmaceutical product according to any one of claims 1 and 2, for promoting dopamine synthesis ability, increasing dopamine content, or promoting dopamine secretion. 細粒剤、茶剤、煎剤、カプセル剤、錠剤、顆粒剤、ゼリー剤、散剤、液剤、シロップ剤またはエキス製剤の形態である、請求項１〜４のいずれか記載の医薬品。 The pharmaceutical product according to any one of claims 1 to 4 , which is in the form of a fine granule, tea, decoction, capsule, tablet, granule, jelly, powder, solution, syrup or extract. 生薬成分がイレイセン、ウヤク、エンゴサク、オウギ、オウゴン、オウバク、オンジ、カッコウ、カッコン、カンキョウ、カンゾウ、キキョウ、キクカ、キジツ、キョウニン、ケイヒ、コウカ、コウブシ、コウボク、ゴシツ、ゴシュユ、ゴミシ、サイコ、サンシシ、ジオウ、シャクヤク、ショウキョウ、ショウマ、シンキク、セッコウ、センキュウ、ゼンコ、ソウジュツ、ソボク、ソヨウ、ダイオウ、タイソウ、ダイフクヒ、タクシャ、チクジョ、チモ、チョウトウコウ、テンマ、テンモンドウ、トウキ、トウニン、ニンジン、バクガ、バクモンドウ、ハンゲ、ビャクシ、ビャクジュツ、ビンロウジ、ブクリョウ、ボウイ、ボウショウ、ボウフウ、ボタンピ、マオウ、モクツウ、モッコウ、ヤクモソウ、リュウタンおよびワキョウカツからなる群から選択される１以上の生薬成分である、請求項１〜５のいずれか記載の医薬品。 Herbal medicine ingredients are Ireisen, Uyaku, Engosaku, Ogi, Ogon, Oubak, Onji, Cuckoo, Cuckoo, Kyokyo, Kanzo, Kyoku, Kikuka, Kijitsu, Kyonin, Keihi, Koka, Koubushi, Kokuboku, Goshitsu, Goshiyu, Ganoderma , Jiou, peonies, ginger, ginger, ginkgo, gypsum, senkou, zenko, suzutsu, soboku, soyo, diou, taisou, daifukuhi, takusha, chikujo, chimo, butterfly, tenma, tenmondo, touki, tonin, carrot, cucumber , Bakumondou, Hange, Bakushi, Sandalwood, Betel Shrimp, Buckle, Bowie, Bowshaw, Bowfish, Buttonpi, Maou, Mokutsu, Mokko, Yakumosou, Ryutan and Wakakatsu Is one or more herbal ingredients selected from the group, medicament according to any one of claims 1 to 5. 生薬成分がカンゾウ、サイコ、センキュウ、チョウトウコウ、トウキ、ハンゲ、ビャクジュツおよびブクリョウの混合物である、請求項１〜６のいずれか記載の医薬品。The medicinal product according to any one of claims 1 to 6, wherein the herbal medicine component is a mixture of licorice, psycho, senkyu, butterfly, touki, hange, sandalwood, and broom. 乾燥植物組織１００重量％に対してノビレチンを０．３〜２．０重量％含有し、ナリルチンを０．４重量％以下含有し、タンゲレチンを０．１〜０．８重量％含有し、ヘスペリジンを０．４〜１２重量％含有し、ノビレチン／ナリルチンの含有重量比が１．０〜２３．０である柑橘類の乾燥植物組織から水抽出により得られる抽出物を含有する食品であって、  Contains nobiletin 0.3 to 2.0% by weight, 100% by weight of dry plant tissue, contains 0.4% by weight or less of naryltin, contains 0.1 to 0.8% by weight of tangeretin, and contains hesperidin. A food containing an extract obtained by water extraction from dried plant tissue of citrus fruits containing 0.4 to 12% by weight and a nobiletin / nariltin content weight ratio of 1.0 to 23.0,
柑橘類がシトラス・レチクラータ・ブランコ（ルタシー）、タチバナまたはオオベニミカンである、食品。  A food product wherein the citrus fruit is Citrus reticulata blanco (Lutacy), Tachibana or Giant orange. 植物組織抽出物１００重量％に対してノビレチンを０．６〜３．０重量％含有し、ナリルチンを０．４重量％以下含有し、タンゲレチンを０．１〜１．０重量％含有し、ヘスペリジンを１．８〜６．０重量％含有し、ノビレチン／ナリルチンの含有重量比が２．０〜１４．０である柑橘類の植物組織抽出物を含有する食品であって、
柑橘類がシトラス・レチクラータ・ブランコ（ルタシー）、タチバナまたはオオベニミカンである、食品。 Nobiletin is contained in an amount of 0.6 to 3.0% by weight, naryltin is contained in an amount of 0.4% by weight or less, tangeretin is contained in an amount of 0.1 to 1.0% by weight, and hesperidin is contained in 100% by weight of the plant tissue extract. the containing 1.8 to 6.0 wt%, a food product containing a weight ratio of nobiletin / Nariruchin contains citrus plant tissue extract is from 2.0 to 14.0,
A food product wherein the citrus fruit is Citrus reticulata blanco (Lutacy), Tachibana or Giant orange.
JP2014052426A 2010-02-26 2014-03-14 Dried plant tissue and plant tissue extract for improving central nervous degenerative diseases accompanied by learning / memory disorders and movement disorders, and pharmaceuticals and foods containing them Active JP5906267B2 (en)

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JP2010270578 2010-12-03
JP2014052426A JP5906267B2 (en) 2010-02-26 2014-03-14 Dried plant tissue and plant tissue extract for improving central nervous degenerative diseases accompanied by learning / memory disorders and movement disorders, and pharmaceuticals and foods containing them

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HK1199831A1 (en) * 2012-06-21 2015-07-24 小太郎汉方制药株式会社 Composition for improving and/or treating central nervous system degenerative disease
CN103479743B (en) * 2013-01-28 2015-07-08 钱昌美 Pharmaceutical composition for treating senile dementia and preparation method thereof
JP6179891B2 (en) * 2013-05-29 2017-08-16 要 有持 Production methods, processing methods, processed products and tea
JP2015053939A (en) * 2013-09-10 2015-03-23 久子 松野 Processed food of skin of orange
WO2015199118A1 (en) * 2014-06-26 2015-12-30 日本ゼオン株式会社 Method for promoting phosphorylation of erk or akt in cultured cell, cell culture method, and phosphorylation promoter
JP2016056149A (en) * 2014-09-11 2016-04-21 日油株式会社 Skin cosmetics
KR102005273B1 (en) * 2014-11-12 2019-07-30 주식회사 파마코렉스 Medicinal composition for preventing or improving dysuria, antagonist against dysuria-related receptor, and method for preventing or improving dysuria using medicinal composition or antagonist
JP6238089B1 (en) * 2016-06-01 2017-11-29 株式会社三協ホールディングス Pharmaceutical composition and food
JP6898628B2 (en) * 2016-06-15 2021-07-07 国立大学法人広島大学 Neurodegenerative disease therapeutic agent
CN107648349A (en) * 2017-10-30 2018-02-02 江西中医药大学 Bitter orange flower is preparing the application in improving sleep-disorder or improving failure of memory or treat Alzheimer disease drugs or health food
WO2019102602A1 (en) * 2017-11-27 2019-05-31 康 大泉 Screening method
KR101894491B1 (en) * 2018-04-30 2018-09-04 주식회사 뉴트라팜텍 A composition for improving memory or cognitive function comprising a aurantii fructus immaturus supercritical extract as an active ingredient
CN112402409A (en) * 2020-12-11 2021-02-26 江汉大学 Application of hesperetin in preparation of drugs for inhibiting beta-secretase activity
CN115886258B (en) * 2022-12-30 2024-07-05 上海交大昂立股份有限公司 Composite probiotic composition for improving physiological memory attenuation

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WO2002053152A1 (en) * 2001-01-08 2002-07-11 Imperial College Of Science, Technology & Medicine Composition containing flavonoids for treatment brain disorders
JP2008127325A (en) * 2006-11-20 2008-06-05 Tokyoto Koreisha Kenkyu Fukushi Shinko Zaidan Phosphorylated MBP production promoter

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