JP2012189909A - Vascular lesion model - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a vascular lesion model which approximates an actual lesion part in a living organism and can be suitably used for training of blood vessel extension technique.SOLUTION: The vascular lesion model is formed of a plurality of small lesion parts different in hardness. In the vascular lesion model, the plurality of small lesion parts include first and second small lesion parts extending along a center axis direction, and it is preferable that the first small lesion parts are surrounded with the second small lesion parts.

Description

The present invention relates to a vascular lesion model.

Conventionally, vasodilation or angioplasty (hereinafter, also simply referred to as vasodilation) is known in which blood flow is restored by dilating a stenotic or occluded blood vessel.

In percutaneous coronary angioplasty (hereinafter also simply referred to as PTCA), which is known as one of the vasodilation methods, for example, blood flow is restored as follows.
First, the tip of the guiding catheter is fixed to the coronary artery ostium.
Next, the guide wire is inserted into the lumen of the guiding catheter, and the guide wire is advanced to the lesioned part where the coronary artery is narrowed or occluded.
Then, the guide wire is passed through the lesion, and the balloon catheter is advanced to the lesion along the guide wire that has passed through the lesion.
Finally, the blood vessel wall is expanded by expanding the balloon to restore blood flow.

In this way, in vasodilation, passing the guide wire through the lesion greatly affects the success or failure of the surgery, but the lesion is formed of various layers with different hardness. Whether it can be passed or not depends largely on the skill of the technician. In particular, in the case of a chronic total occlusion lesion (hereinafter also simply referred to as “CTO”), not only a guide wire to be used but also a very advanced technique is required for procedures such as a guide wire rotation operation.

Therefore, various vascular lesion models imitating actual lesions have been proposed for the purpose of improving the skill of the operator.

For example, Patent Document 1 discloses a vascular lesion model in which a polymer such as polystyrene is filled in a cylindrical simulated blood vessel.
It is said that this vascular lesion model can be used for training such as coronary atherectomy.

JP 2010-178809 A

However, since the conventional vascular lesion model described in Patent Document 1 is formed of a single layer of polymer, the hardness is uniform, and it cannot be said that the above-mentioned actual lesion is sufficiently approximated. There is a problem.

As a result of intensive studies to solve the above problems, the present inventor has found that a lesion model can be approximated to an actual lesion by forming a lesion model from a plurality of small lesions having different hardnesses.
As a result of further investigation based on the findings of the present inventors, the vascular lesion model of the present invention, which approximates to an actual lesion and can be suitably used for vasodilation training, has been completed. .

That is, the vascular lesion model of the present invention is characterized in that it is formed of a plurality of small lesion portions having different hardnesses.

The vascular lesion model of the present invention approximates an actual lesion and can be suitably used for vasodilation training.
The configuration and effect of the vascular lesion model of the present invention will be described in detail below with reference to the drawings.

FIG. 1A is a perspective view schematically showing a vascular lesion model according to an embodiment of the present invention housed in a simulated blood vessel, and FIG. 1B is a blood vessel shown in FIG. It is a vertical sectional view schematically showing a cross section of a lesion model cut perpendicularly along the central axis direction.
FIG. 1C is a first end view of the vascular lesion model shown in FIG. 1A viewed from the first end face side (left end face side), and FIG. 1D is shown in FIG. It is the 2nd end view which looked at the vascular lesion model from the 2nd end surface side (right end surface side).

The vascular lesion model 1 of the present invention shown in FIGS. 1 (a), 1 (b), 1 (c) and 1 (d) is a first small lesion, which is a plurality of small lesions having different hardnesses A portion 2a, a second small lesion 2b, and a third small lesion 2c are formed.
1A, FIG. 1B, FIG. 1C, and FIG. 1D, three small lesions (first small lesion 2a, second small lesion 2b, and third Although the vascular lesion model formed from the small lesion part 2c) is illustrated, the number of the small lesion part is not limited to three as long as it is plural.
Moreover, although the 1st small lesion part 2a, the 2nd small lesion part 2b, and the 3rd small lesion part 2c block the lumen | bore of the tubular simulated blood vessel 3, the simulated blood vessel 3 does not need to be provided.

In the vascular lesion model 1 of the present invention having such a configuration, for example, it is possible to simulate a soft lesion by making the hardness of the first small lesion 2a the most, and the hardness of the second small lesion 2b. A moderate lesion can be simulated by setting the thickness to a medium level, and a fibrous lesion can be simulated by making the hardness of the third small lesion 2c the hardest.
Therefore, the vascular lesion model 1 of the present invention approximates an actual lesion.

By using the vascular lesion model 1 of the present invention for training of vasodilation, for example, the technique of the operator can be improved.
This will be described below.

First, in the actual procedure, if the guide wire is strayed into a harder lesion or fibrous lesion, the operator rotates or pushes the proximal portion of the guide wire to pass the guide wire. It is necessary to perform complicated operations such as pulling.

Here, when the vascular lesion model 1 of the present invention is used for training, the guide wire often enters the inside from the softest first small lesion 2a.
However, the guide wire may pass only through the first small lesion 2a due to the difference in properties such as the flexibility of the tip of the guide wire or the difference in the method of operating the guide wire by the operator. The guide wire may get into the second small lesion 2b or the third small lesion 2c.
When the guide wire enters the second small lesion part 2b or the third small lesion part 2c, the second small lesion part 2b and the third small lesion part 2c are harder. Need to do complex operations.
Since such a situation can also occur in the actual procedure described above, when the vascular lesion model 1 of the present invention is used for vasodilation training, it is possible to improve the technique of the operator.

In the vascular lesion model of the present invention, the plurality of small lesion portions include a first small lesion portion and a second small lesion portion extending along the central axis direction of the vascular lesion model, The first small lesion is preferably surrounded by the second small lesion.
In the present specification, the “center axis of the vascular lesion model” means that when the vascular lesion model according to the present invention is accommodated in the simulated blood vessel, it passes through the approximate center of the simulated blood vessel from the one end surface side to the other. A virtual axis that passes through to the end face side is assumed.

In the vascular lesion model of the present invention, it is desirable that the plurality of small lesion portions are formed of a transparent material, and at least one small lesion portion is colored among the plurality of small lesion portions.

In the vascular lesion model of the present invention, it is desirable that the plurality of small lesion portions be formed from a gel.

In the vascular lesion model of the present invention, the gel is preferably formed from a material containing a polysaccharide.

In the vascular lesion model of the present invention, the gel is preferably formed from a material containing agarose.

In the vascular lesion model of the present invention, a simulated blood vessel that accommodates the plurality of small lesion portions,
A stop that is disposed on at least one of the first end surface side and the second end surface side of the simulated blood vessel and protrudes from the lumen wall of the simulated blood vessel toward the central axis of the vascular lesion model And further having a member,
It is desirable that the stopping member is in contact with at least one small lesion portion among the plurality of small lesion portions.

FIG. 1A is a perspective view schematically showing a vascular lesion model according to an embodiment of the present invention housed in a simulated blood vessel, and FIG. 1B is a blood vessel shown in FIG. It is a vertical sectional view schematically showing a cross section of a lesion model cut perpendicularly along the central axis direction. FIG. 1C is a first end view of the vascular lesion model shown in FIG. 1A viewed from the first end face side (left end face side), and FIG. 1D is shown in FIG. It is the 2nd end view which looked at the vascular lesion model from the 2nd end surface side (right end surface side). FIG. 2 (a) is a vertical cross-sectional view schematically showing a cross section obtained by vertically cutting a vascular lesion model according to another embodiment of the present invention housed in a simulated blood vessel along its central axis direction, 2B is a first end view of the vascular lesion model shown in FIG. 2A viewed from the first end face side (left end face side), and FIG. 2C is shown in FIG. It is the 2nd end view which looked at the vascular lesion model from the 2nd end surface side (right end surface side).

(First embodiment)
Hereinafter, a first embodiment which is an embodiment of a vascular lesion model of the present invention will be described with reference to the drawings.
Since the vascular lesion model of this embodiment has the same configuration as the vascular lesion model of the present invention described above, in the following description, FIG. 1 (a), FIG. 1 (b), FIG. A description will be given with reference to FIG.
In addition, about the matter which overlaps with the description which concerns on the vascular lesion model of this invention, description is abbreviate | omitted.

The vascular lesion model 1 of the present embodiment shown in FIGS. 1 (a), 1 (b), 1 (c), and 1 (d) includes a columnar first small lesion 2a having different hardness from each other. The second small lesion 2b and the third small lesion 2c are formed.
The first small lesion 2a, the second small lesion 2b, and the third small lesion 2c are housed inside the tubular simulated blood vessel 3.

The first small lesion 2 a is cylindrical and extends along the direction of the central axis L of the vascular lesion model 1. The central axis L of the vascular lesion model 1 is a virtual axis as already described.

The second small lesion 2b has a cylindrical shape whose inner diameter is substantially the same as the outer diameter of the first small lesion 2a, and extends along the direction of the central axis L of the vascular lesion model 1.
The first small lesion 2a is accommodated inside the second small lesion 2b, and the first small lesion 2a is surrounded by the second small lesion 2b.

The third small lesion 2c has a cylindrical shape whose inner diameter is substantially the same as the outer diameter of the second small lesion 2b, and extends along the direction of the central axis L of the vascular lesion model 1.
The first small lesion 2a and the second small lesion 2b are accommodated inside the third small lesion 2c, and the first small lesion 2a and the second small lesion 2b are contained in the third small lesion 2c. It is surrounded by.
Further, the outer peripheral surface of the third small lesion 2 c is in contact with the lumen wall of the simulated blood vessel 3.

The first small lesion 2a, the second small lesion 2b, and the third small lesion 2c are preferably formed from a transparent material.
Specifically, the first small lesion 2a, the second small lesion 2b, and the third small lesion 2c are more preferably formed from a gel that is a transparent material.

Examples of the gel material include agarose, starch, chitosan, collagen, gelatin, polyacrylamide, sodium polyacrylate, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose. And cationized cellulose.
Among these, a material containing a polysaccharide (agarose, starch, chitosan, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, cationized cellulose) is more desirable.
In particular, the material for the gel is more preferably a material containing agarose.
The gel can be prepared by absorbing an appropriate amount of a solvent such as water or physiological saline in the material of the gel.

When the first small lesion 2a, the second small lesion 2b, and the third small lesion 2c are formed of gel, the hardness of the first small lesion 2a is 5000 to 6000 gf / cm ² , hardness of the two small lesions 2b is a 7000~8000gf / cm ^2, the hardness of the third small lesion 2c is desirably 9000~10000gf / cm ^2.
When the hardness of the first small lesion 2a, the second small lesion 2b and the third small lesion 2c formed from the gel is within the above range, the first small lesion 2a approximates a soft lesion, The second small lesion 2b approximates a moderate lesion and the third small lesion 2c approximates a fibrous lesion, and the vascular lesion model 1 is particularly preferably used for vasodilation training. it can.
In addition, in this specification, the hardness (gf / cm < ² >) of a gel shall show the value measured by JISK6503.

Examples of transparent materials other than gel include polystyrene-poly (ethylene / propylene) block copolymer, polystyrene-poly (ethylene / propylene) block-polystyrene copolymer, polystyrene-poly (ethylene / butylene) block- A polymer comprising one or a mixture of two or more copolymers selected from the group consisting of polystyrene copolymers, polystyrene-poly (ethylene-ethylene / propylene) block-polystyrene copolymers; What contains the softening agent to soften is mentioned.
As the softening agent, a rubber compounding oil can be preferably used, and a process oil can be particularly preferably used. The process oil is not particularly limited, and any of paraffinic, naphthenic, and aromatic oils may be used, or one or more of these may be used in combination.
In addition, silicone clay, rubber clay, resin clay, oil clay, and the like may be used.

Of the first small lesion 2a, the second small lesion 2b, and the third small lesion 2c, it is desirable that at least one small lesion is colored.
For example, the first small lesion 2a may be colored with a pigment or dye such as red or blue, and the second small lesion 2b and the third small lesion 2c may not be colored. The first small lesion part 2a and the second small lesion part 2b may be colored, and the third small lesion part 2c may not be colored. The embodiment in which 2b and the third small lesion part 2c are all colored may be used.
In addition, when two or more small lesions are colored, they may be colored with the same color or different colors.

The simulated blood vessel 3 that accommodates the first small lesion part 2a, the second small lesion part 2b, and the third small lesion part 2c is not necessarily provided, but when the simulated blood vessel 3 is provided, It can be approximated by an actual lesion.

Examples of the material of the simulated blood vessel 3 include silicone elastomer, silicone rubber such as silicone gel, polyurethane elastomer, silicone resin, epoxy resin, thermosetting resin such as phenol resin, polymethyl methacrylate, polyvinyl chloride, and polyethylene. These can be used, and one or more of these can be used in combination. The simulated blood vessel 3 formed from these materials is excellent in transparency and has properties such as flexibility that are close to those of an actual blood vessel (for example, coronary artery).
Among these materials, it is particularly preferable to use silicone rubber.

A stop member 4 is disposed on the second end surface 3b side of the simulated blood vessel 3 on the first end surface 3a side and the second end surface 3b side.
The stop member 4 has an outer diameter substantially the same as the inner diameter of the simulated blood vessel 3, and the inner diameter is a plurality of small lesions composed of a first small lesion 2a, a second small lesion 2b, and a third small lesion 2c. It is a ring shape slightly smaller than the outer diameter.
The stop member 4 fixed to the lumen wall of the simulated blood vessel 3 protrudes from the lumen wall of the simulated blood vessel 3 toward the central axis L of the vascular lesion model 1 and is in contact with the third small lesion portion 2c. .
The stop member 4 only needs to be in contact with at least one of the plurality of small lesions. For example, the stop member 4 is in contact with the second small lesion 2b or the third small lesion 2c. Also good.
The material of the stop member 4 may be a polymer such as polyethylene or a metal such as stainless steel.
Moreover, the stop member 4 may be arrange | positioned only at the 1st end surface 3a side, and may be arrange | positioned at the 1st end surface 3a side and the 2nd end surface 3b side. The stop member 4 is preferably disposed, but may not be disposed.

The vascular lesion model of this embodiment can be manufactured as follows, for example.
Here, a case where an agarose gel is used as a material for a small lesion will be described.

(1) Preparation of first small lesion part A predetermined amount of solvent (water, etc.) and a predetermined amount of agarose powder are mixed and heated so that the hardness of the first small lesion part after hardening becomes a desired hardness. While stirring uniformly, a mixture in which agarose is dispersed in a solvent is prepared. At this time, the mixture may be colored by adding a desired pigment or dye to the mixture.
The mixture is poured into a mold having a cylindrical lumen and cooled to produce a cylindrical first small lesion.

(2) Preparation of second small lesion part By changing the amount of solvent and the amount of agarose powder so that the hardness after curing is different from that of the first small lesion part, by going through the same process as step (1) Prepare the mixture. Separately, a mold having a larger lumen than the mold used in step (1) is prepared.
The first small lesion part produced in the step (1) is set in advance in the mold, and the mixture is poured into the mold so as to surround the outer periphery of the first small lesion part.
Thereafter, by cooling the mold, an intermediate composed of the first small lesion and the second small lesion surrounding the first small lesion is produced.

(3) Production of third small lesion part The same as step (1) except that the amount of solvent and the amount of agarose powder are changed so that the hardness after curing is different from the first small lesion part and the second small lesion part. A mixture is prepared by going through the following steps. Separately, a mold having a larger lumen than that used in step (2) is prepared.
The intermediate produced in the step (2) is set in advance in the mold, and the mixture is poured into the mold so as to surround the outer periphery of the intermediate.
Then, by cooling the mold, the first small lesion, the second small lesion surrounding the first small lesion, and the third small lesion surrounding the second small lesion, The vascular lesion model of this embodiment consisting of is manufactured.

The manufactured vascular lesion model may be inserted into a tubular simulated blood vessel whose outer diameter and inner diameter are substantially the same.
Moreover, you may arrange | position a stop member in the 2nd end surface side and / or 2nd end surface side of a simulated blood vessel as needed.

Hereinafter, effects of the vascular lesion model of the first embodiment will be listed.

(1) The vascular lesion model of the present embodiment is formed of a first small lesion, a second small lesion, and a third small lesion with different hardness, and extends along the central axis direction of the vascular lesion model. Because the existing first small lesion is surrounded by the second small lesion, it is more similar to the actual lesion in the living body. It can contribute sufficiently to the improvement.

(2) When the first small lesion part, the second small lesion part, and the third small lesion part are formed of a transparent material, it is easy to observe the vasodilation training from the outside.
In particular, when at least one small lesion is colored, it is easier to observe vasodilation training from the outside.

(3) When the first small lesion, the second small lesion, and the third small lesion are formed from gel, the hardness can be easily changed by adding a solvent such as water, The degree of freedom in designing the hardness is increased, and it is possible to closely approximate an actual lesion in a living body.
When the gel is formed from a material containing a polysaccharide, it is particularly easy to adjust the hardness by adding a solvent, and such an effect can be suitably enjoyed. Especially, when a gel is formed from the material containing agarose, the effect which concerns can be enjoyed more suitably.

(4) Since a stop member that protrudes inward of the simulated blood vessel is formed, the pushing force along the central axis direction with respect to the first small lesion, the second small lesion, and the third small lesion is Even when a tensile force is applied, the first small lesion part, the second small lesion part, and the third small lesion part are stopped by the stop member and are not easily displaced from the initial position.

(Second embodiment)
Hereinafter, a second embodiment which is an embodiment of the vascular lesion model of the present invention will be described with reference to the drawings.
In the vascular lesion model of the present embodiment, a conical cap member covering the end surface is formed on at least one end surface of the first end surface and the second end surface of the plurality of small lesion portions, It has the same configuration as the vascular lesion model described in the first embodiment of the present invention.
Therefore, the description overlapping with the description of the vascular lesion model of the first embodiment of the present invention is omitted.

FIG. 2 (a) is a vertical cross-sectional view schematically showing a cross section obtained by vertically cutting a vascular lesion model according to another embodiment of the present invention housed in a simulated blood vessel along its central axis direction, 2B is a first end view of the vascular lesion model shown in FIG. 2A viewed from the first end face side (left end face side), and FIG. 2C is shown in FIG. It is the 2nd end view which looked at the vascular lesion model from the 2nd end surface side (right end surface side).

The vascular lesion model 1 of this embodiment shown in FIGS. 2 (a) and 2 (b) is a cylindrical first small lesion 2a, second small lesion 2b, and third small lesion 2c having different hardness. The first small lesion 2a, the second small lesion 2b, and the third small lesion 2c are housed inside the tubular simulated blood vessel 3.
Detailed configurations of the first small lesion 2a, the second small lesion 2b, and the third small lesion 2c are the same as those of the vascular lesion model of the first embodiment.

At least one of the first end surface 2d and the second end surface 2e of the first small lesion 2a, the second small lesion 2b, and the third small lesion 2c has a conical cap that covers the end surface. A member 5 is formed. In the example shown in FIG. 2A and FIG. 2B, the first cap member 5a covers the first end surface 2d, and the second cap member 5b covers the second end surface 2e.

More specifically, the top of the first cap member 5a is in contact with the first end surface 2d of the first small lesion portion 2a, and the bottom surface of the first cap member 5a is the first end surface of the vascular lesion model 1. Is forming. The gaps between the first cap member 5a and the plurality of small lesions are filled with the first gap member 6a.

The apex of the second cap member 5b is in contact with the second end surface 2e of the first small lesion 2a, and the bottom surface of the second cap member 5b forms the second end surface of the vascular lesion model 1.
The gap between the second cap member 5b and the plurality of small lesions is filled with the second gap member 6b.

The material of the first cap member 5a, the second cap member 5b, the first gap member 6a, and the second gap member 6b is the same as the material of the small lesion part in the vascular lesion model of the first embodiment.

The hardness of the first cap member 5a and the second cap member 5b is the first small lesion 2a, the second small lesion 2b, the third small lesion 2c, the first cap member 5a, the second cap member 5b, It is the hardest of the first gap member 6a and the second gap member 6b.
For example, it is desirable that the hardness of the first cap member 5a and the second cap member 5b exceeds 10,000 gf / cm ² .

Also in the vascular lesion model of the present embodiment, it is desirable that at least one small lesion portion is colored as in the vascular lesion model of the first embodiment.
Moreover, you may have further the stop member arrange | positioned by the at least 1 end surface side of the 1st end surface side and 2nd end surface side of the simulated blood vessel.

The vascular lesion model of the present embodiment can be manufactured by continuing the following step (4) after the step (3) in the method of manufacturing the vascular lesion model of the first embodiment.

(4) Preparation of the first cap member and the second cap member The first end surface of the first small lesion part, the second small lesion part, and the third small lesion part are filled with a mixture that becomes the first gap member after curing, A separately prepared conical first cap member is fitted.
Similarly, the second end face of the first small lesion part, the second small lesion part, and the third small lesion part are filled with a mixture that becomes the second gap member after curing, and a conical second cap member produced separately. Fit.
Then, the blood vessel lesion model of this embodiment can be manufactured by cooling.
The first cap member and the second cap member can be produced by pouring the mixture described in the step (1) of the first embodiment into a mold having a predetermined shape and then cooling, but after curing. A mixture is used in which the amount of solvent and the amount of agarose powder are changed so that the hardness of is the hardest.
Moreover, about the mixture used as the 1st gap member after hardening, and the mixture used as the 2nd gap member after hardening, it is possible to use the mixture of the composition similar to the mixture demonstrated in the process (1) of 1st embodiment. it can.

Hereinafter, effects of the vascular lesion model of the second embodiment will be listed.
Even in the vascular lesion model of this embodiment, the effects (1) to (4) of the first embodiment described above can be exhibited.
Moreover, the following effect (5) can also be exhibited.

(5) The hardest first cap member and second cap member among the plurality of small lesions and the like cover the first end surface and the second end surface of the plurality of small lesions. Since such a vascular lesion model closely approximates an actual CTO lesion in a living body, the vascular lesion model of the present embodiment can be suitably used for vasodilation training for a CTO lesion.

(Other embodiments)
In the vascular lesion model of the present invention, the shape of each small lesion portion may be a shape extending along the central axis of the vascular lesion model, such as the above-described columnar shape or cylindrical shape, The shape may be a columnar shape or a cylindrical shape, and may have one or a plurality of side branches branched from the central axis of the vascular lesion model to the outside (simulated blood vessel side).
In addition, the shape of each small lesion part may extend linearly from the first end surface side to the second end surface side as shown in FIGS. 1 (b) and 2 (a), You may meander from the 1st end surface side toward the 2nd end surface side.
In addition, a substantially spherical hard portion or soft portion may be scattered inside the plurality of small lesion portions.
A vascular lesion model having a small lesion part of these shapes is preferable because it closely approximates an actual lesion part in a living body.

In the vascular lesion model of the present invention, the shape of the first end surfaces of the plurality of small lesion portions may be flat as shown in FIG. 1 (a), FIG. 1 (b) and FIG. 2 (a), The central portion of the first end surface may be recessed in a concave shape. Similarly, the shape of the second end surfaces of the plurality of small lesions may be flat, or the central portion of the second end surfaces may be recessed.
It is preferable to have a small lesion part having such a shape, because it closely approximates an actual lesion part in a living body.

In the vascular lesion model of the present invention, slits that extend toward the inside may be formed on the first end surface and / or the second end surface of the plurality of small lesion portions. Such a slit imitates a microchannel in a CTO lesion, and such a vascular lesion model closely approximates an actual CTO lesion in a living body. It can be preferably used.

1 Vascular lesion model 2a First small lesion 2b Second small lesion 2c Third small lesion

Claims (7)

A vascular lesion model characterized by being formed from a plurality of small lesions having different hardness. The plurality of small lesions include a first small lesion and a second small lesion extending along the direction of the central axis of the vascular lesion model,
The vascular lesion model according to claim 1, wherein the first small lesion part is surrounded by the second small lesion part. The plurality of small lesions are formed of a transparent material,
The vascular lesion model according to claim 1 or 2, wherein at least one small lesion portion among the plurality of small lesion portions is colored. The vascular lesion model according to claim 3, wherein the plurality of small lesion portions are formed of a gel. The vascular lesion model according to claim 4, wherein the gel is formed of a material containing a polysaccharide. The vascular lesion model according to claim 5, wherein the gel is formed of a material containing agarose. A simulated blood vessel containing the plurality of small lesions;
A stop that is disposed on at least one of the first end surface side and the second end surface side of the simulated blood vessel and protrudes from the lumen wall of the simulated blood vessel toward the central axis of the vascular lesion model And further having a member,
The vascular lesion model according to any one of claims 1 to 6, wherein the stop member is in contact with at least one small lesion portion among the plurality of small lesion portions.

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