JP2012036119A - Oil-in-water-type emulsified composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oil-in-water-type emulsified composition containing an amino acid, excellent in stability with time without getting malodorous and discolored and the like, and also free from sliminess and having fresh infiltrative feeling.SOLUTION: The oil-in-water-type emulsified composition includes: (A) a D-amino acid and/or a salt thereof; (B) a chelating agent; (C) a polyoxyethylene fatty acid sorbitan with its fatty acid moiety derived from a 14C-18C straight-chain saturated fatty acid; (D) an N-acyl methyl taurine salt; (E) a higher alcohol; (F) water; and (G) an oil fraction liquid at room temperature. This composition is such that: with the components (C) to (G), a gel having a transition temperature of 60°C or higher may be formed.

Description

  The present invention relates to an oil-in-water emulsion composition. More specifically, the present invention relates to an oil-in-water emulsified composition that contains an amino acid, is stable with no odor and discoloration, and has a fresh feeling of use without sliminess.

  The oil-in-water emulsion composition is widely used as a base for external preparations for skin including skin cosmetics because of its fresh feeling. However, it is known that emulsions (emulsions) are essentially unstable and cause phenomena such as creaming, aggregation or coalescence when left for a long period of time. In conventional emulsions and creams, stability over time has been ensured by incorporating a carboxyvinyl polymer, which is a general water-soluble thickener.

However, when a large amount of a water-soluble polymer such as carboxyvinyl polymer or polysaccharide is blended, it has been difficult to eliminate slime, spread weight, stickiness, and kinking during application.
For example, Patent Document 1 discloses an oil-in-water emulsified makeup that has no sliminess, freshness, and penetration, by combining polyoxyethylene fatty acid sorbitan, a highly hydrophilic surfactant, and a higher alcohol in specific ratios. It is described that a fee can be obtained.

  On the other hand, the present applicants have been studying the physiological activity of D-amino acids, but the salt-type D-amino acid is added to the oil-in-water emulsion composition containing a general water-soluble thickener. When a water-soluble thickener is added in order to maintain stability, a problem of usability such as stickiness occurs.

  In addition, amino acids have the property of reacting with other compounding ingredients and oxygen in the outside air to cause alteration and discoloration or odor over time, and perfume may be added to mask the odor. It was necessary. For example, in Patent Document 2, nitrogen-containing compounds such as guanidine carbonate, aminoguanidine hydrochloride, and semicarbazide hydrochloride are added to prevent odor and discoloration that occur in water-containing cosmetics in which amino acids and glycerin coexist. Is described.

  Patent Document 3 describes a method for preventing odor and discoloration in water-containing cosmetics containing amino acids and the like by adding a water-soluble reducing agent such as sulfite and / or a chelating agent such as ethylenediaminetetraacetic acid. Yes. In Patent Document 4, a skin external preparation containing a relatively high concentration (up to 12% in the Examples) of an amino acid or a derivative by using the chelating agent added in Patent Document 3 and pyridoxylserine in combination. It has been described that coloring and discoloration with time are suppressed.

  However, in the conventional techniques described in Patent Documents 2 to 4 above, there are cases where the odor change caused by the blending of specific amino acids cannot be completely suppressed, and the effect of suppressing the odor change or discoloration has been confirmed as L -Limited to formulations containing amino acids.

JP 2008-88129 A JP-A-9-136810 JP-A-8-231335 JP 2005-255634 A

  The present invention has been made in view of the problems of the prior art, and has an oil-in-water emulsion composition that has various advantageous effects due to amino acids and does not cause odor or discoloration over time, An object of the present invention is to provide a composition that does not feel slimy and has a fresh and penetrating feeling.

As a result of diligent research to solve the above-mentioned problems, the inventors have replaced a conventionally used L-amino acid with a D-amino acid and added a chelating agent to the odor and discoloration over time. It was found that an oil-in-water emulsion composition having all the desired properties can be obtained by combining with a base that can be suppressed and that forms an α-gel structure, and the present invention has been completed.
That is, the present invention includes (A) D-amino acid and / or a salt thereof, (B) a chelating agent, (C) a polyoxyethylene fatty acid sorbitan derived from a linear saturated fatty acid having 14 to 18 carbon atoms, ( D) N-acylmethyltaurine salt, (E) higher alcohol, (F) water, and (G) oil component that is liquid at room temperature, and having a transition temperature of 60 ° C. or higher with the components (C) to (F). Provided is an oil-in-water emulsion composition that forms a gel having the same.

  According to the present invention, not only has advantageous effects (barrier recovery, anti-oxidation, moisturizing effect, etc.) based on the blended D-amino acids, but the addition of chelating agents suppresses odor and discoloration, and further identification. By combining a base that forms an α-gel structure with the ingredients, there is no decrease in viscosity due to the incorporation of D-amino acids or chelating agents, and stability over time is eliminated, while there is no slimy feeling and a fresh feeling of use and penetration into the skin. An oil-in-water emulsion composition can be obtained.

  The emulsion composition of the present invention essentially contains D-amino acid or a salt thereof (component (A)). As is well known, amino acids include L-forms and D-forms as optical isomers, and natural proteins are those in which L-amino acids are peptide-bonded. With some exceptions such as bacterial cell walls, it has been considered that only L-amino acids exist in the body of mammals including humans, and living organisms use only L-amino acids. Therefore, until now, only L-amino acids have been studied with academic or industrial attention.

  Exceptionally, D-amino acids were used as follows: (1) When used as a raw material for antibiotics produced by bacteria, (2) L-amino acids and D-amino acids obtained in equivalent amounts when chemically synthesizing amino acids The case where it contains in the food additive mix | blended as it is as a DL-amino acid mixture in order to save the cost which fractionates only L-amino acid from an amino acid mixture (racemate) etc. is mentioned.

  Recently, in humans, it has been clarified that D-aspartic acid (D-Asp), which should not originally exist in the eye lens, brain, or skin, increases with aging, and onset of cataract and Alzheimer's disease. (Tadaaki Kinouchi et al., “Protein Nucleic Acid Enzyme”, Vol. 50, No. 5 (2005), pages 453-560). Also in skin, it has been found that D-Asp accumulates due to aging or ultraviolet irradiation, and it has been proposed to apply D-Asp as a molecular marker for knowing skin damage due to aging or ultraviolet light (Noriko Fujii, Cosmetology Research Report, No. 13 (2005) However, there are no known examples in which D-amino acids are actively used as physiologically active substances.

  The present applicant has been researching the physiological activity of D-amino acids, and so far, the antioxidant effect and collagen production promoting effect by D-aspartic acid, the laminin 332 production promoting effect and the collagen production promoting effect by D-alanine. , D-glutamic acid barrier recovery function, wrinkle formation reducing effect, and skin roughness reducing effect, D-hydroxyproline laminin 332 production promoting effect and melanin production inhibiting effect, and D-serine, D-cysteine, D-methionine and The effect of reducing UV damage by D-proline has been confirmed.

  In the present invention, due to the circumstances as described above, when D-amino acid, which has not been conventionally blended in cosmetics, in particular skin cosmetics and skin external preparations, is blended instead of L-amino acid, L-amino acid is blended. This is based on the new finding that the odor change and discoloration seen in the prepared preparation is suppressed, and the suppression effect is further improved by adding a chelating agent.

  The D-amino acid (component (A)) used in the present invention is preferably selected from D-glutamic acid, D-lysine or D-arginine. The D-amino acid in the present invention may be in the form of a free acid or a salt. Examples of the salt include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt, and ammonium salt. , Hydrochloride and the like.

  The D-amino acid and its salt used in the present invention may be synthesized or commercially available. As a method for producing a D-amino acid, for example, a method obtained by allowing a bacterium-derived D-aminoacylase to act on an acylated amino acid is known (see JP-A-11-113582). The D-amino acids or salts thereof of the present invention may be used alone or in combination of two or more.

  The amount of D-amino acid and / or salt thereof in the emulsion composition of the present invention is usually 0.001 to 30% by mass, preferably 0.001 to 10% by mass, more preferably 0.001 to 5% by mass. It is. If the blending amount is less than 0.001% by mass, the effect of the present invention is not sufficient, and even if blending exceeds 30% by mass, no further improvement in the effect is observed.

The oil-in-water emulsion composition of the present invention contains a chelating agent (component (B)) as an essential component in addition to the D-amino acid and / or salt thereof.
The chelating agent used in the present invention is not particularly limited as long as it is a raw material that can be blended in a skin external preparation or skin cosmetic. For example, ethylenediaminetetraacetic acid (EDTA or edetic acid), diethylenetriaminepentaacetic acid pentasodium, ethylenediaminehydroxyethyl triacetic acid trisodium, hydroxyethanedisulfonic acid, sodium gluconate, polyphosphoric acid, metaphosphoric acid and the like can be mentioned. These may be in the form of salts, such as sodium salts and potassium salts.

The chelating agent in this invention can use 1 type (s) or 2 or more types.
In particular, it is preferable to use one or more selected from ethylenediaminetetraacetic acid, hydroxyethanedisulfonic acid, or salts thereof.

  The blending amount of the chelating agent in the external preparation for skin of the present invention is appropriately selected depending on the type of chelating agent used, the type and blending amount of the D-amino acid used in combination, and is usually 0.001 to 20% by mass, preferably 0.005 to 5 mass%, more preferably 0.01 to 1 mass%

The emulsified composition of the present invention is a polyoxyethylene fatty acid sorbitan (component (C): hereinafter referred to as “component fatty acid (C)”), in addition to the D-amino acid or a salt thereof and a chelating agent, the fatty acid portion derived from a linear saturated fatty acid having 14 to 18 carbon atoms. (Also referred to as “POE fatty acid sorbitan”) as an essential component.
The POE fatty acid sorbitan in the present invention has a structure in which polyoxyethylene is bonded to a linear saturated fatty acid having 14 to 18 carbon atoms, for example, stearic acid, palmitic acid, myristic acid, etc., and even a synthesized one is commercially available. It may be what you have. Specific examples include POE (20) sorbitan stearate (eg, NIKKOL TS-10V, manufactured by Nikko Chemicals), POE (20) sorbitan myristic acid, POE (20) sorbitan palmitate (eg, NIKKOL TP-10V, Nikko Chemicals). And POE (6) sorbitan stearate (for example, NIKKOL TS-106V, manufactured by Nikko Chemicals), POE (6) sorbitan myristic acid, POE (6) sorbitan palmitate, and the like. is not. However, those derived from a fatty acid having a branch or a double bond in the fatty acid part are not preferred because they may be inferior in viscosity and stability under long-term storage.

  The compounding quantity of POE fatty acid sorbitan in the emulsion composition of this invention is 0.05-7 mass%, Preferably it is 0.1-5 mass%.

The oil-in-water emulsion composition of the present invention further contains an N-acylmethyl taurine salt (component (D)).
The N-acylmethyl taurine salt in the present invention is preferably an N-acyl taurine salt having an acyl group having 14 to 22 carbon atoms. Specific examples include N-stearoyl methyl taurine salt, N-palmitoyl methyl taurine salt, and N-myristol methyl taurine salt, and N-stearoyl methyl taurine salt is particularly preferable.

The oil-in-water emulsion composition of the present invention further contains a higher alcohol (component (E)).
The higher alcohol used in the present invention is preferably one or more aliphatic alcohols having a linear or branched alkyl group having 12 to 22 carbon atoms.
Specific examples include linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, hardened rapeseed oil alcohol, jojoba alcohol, batyl alcohol, 2-decyltetradecinol, Examples include branched chain alcohols such as lanolin alcohol, cholesterol, phytosterol, hexyl decanol, isostearyl alcohol, and octyldodecanol.
When a mixture of two or more fatty alcohols is used, it is preferable that the mixture has a melting point of 60 ° C. or higher. For example, the combination of stearyl alcohol and behenyl alcohol can be mentioned.

  Furthermore, the oil-in-water emulsion composition of the present invention contains water (component (F)) as an essential component, and the water forms the outer phase of the emulsion.

In the emulsified composition of the present invention, the amount of N-acylmethyl taurine salt (component (D)) forming the gel is preferably 0.1 to 1% by mass. If it is less than 0.1% by mass, the emulsion stability is lowered, and if it exceeds 1% by mass, stickiness may occur.
The blending amount of the higher alcohol (component (E)) in the emulsified composition of the present invention is an amount sufficient to form a gel according to the blending amount of the component (D).
In addition, it is preferable that the compounding ratio of the said (D) component and (E) component shall be 1: 3 by molar ratio.

  The gel in the present invention can be understood as an aggregate comprising a lamellar structure of (D) component and (E) component formed in the aqueous phase. It can be confirmed by DSC (Differential Scanning Calorimetry) that the (D) component and the (E) component form an aggregate. That is, the endothermic peak of the sample in which both the (D) component and the (E) component are mixed and dispersed in water is the endothermic peak obtained by the sample in which each of the (D) component and (E) component is dissolved or dispersed in water alone. A single endothermic peak is shown on the higher temperature side than the peak, but when the component ratio of component (E) is low (component (E) is insufficient), the temperature of the endothermic peak of the aggregate is low, and the temperature is After increasing the composition ratio of the component (E) and completing the aggregate structure, when the component (E) becomes excessive, it becomes constant and an excessive peak of the component (E) appears.

  Here, when the aggregate structure is completed, the (D) component is used when the aggregate is formed by the component (D) having a single alkyl chain and the component (E) having a single alkyl chain. It is known that there are 3 moles of component (E) per mole. In the present invention, an excess (E) component or an amphiphilic substance that does not participate in the formation of the gel may be further contained, and the content thereof is 0.5 to 5 with respect to the total amount of the oil-in-water emulsion composition. It is preferable to set it as 10 mass%.

The amphiphilic substance other than the component (E) is preferably an amphiphilic substance having a melting point of 55 ° C. or higher, more preferably 60 ° C. or higher. If the melting point of the amphiphilic substance to be blended is less than 55 ° C., the temperature stability of the system may be lowered depending on the formulation, and creaming may occur.
These amphiphiles are preferably those having surface activity but having a high hydrophobicity per se and less surface activity than general surfactants. For example, higher fatty acids, monoglycerides, glycerol monoalkyl ethers, monoalkyls. Examples include amines and sterols. Specific examples include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tolic acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), higher fatty acids such as docosahexaenoic acid (DHA); sterols such as cholesterol and phytosterol; monoglycerides, glycerol monoalkyl ethers, monoalkylamines, and the like, but are not limited to these examples.

  Furthermore, in the present invention, in addition to the essential components (C) and (D) that form a gel, a lipophilic nonionic surfactant, a cationic surfactant, an anionic surfactant, or an amphoteric interface An activator can be mix | blended unless the effect of this invention is impaired. In addition, (D) component which does not participate in formation of a gel may exist.

The oil component (component (G)) that is liquid at room temperature and blended in the oil-in-water emulsion composition of the present invention can be appropriately selected from those generally used in cosmetics in a range that does not impair the stability.
The blending amount of the liquid oil ((G) component) in the emulsion composition of the present invention can be appropriately selected according to the required properties, but is usually 1 to 50% by mass, preferably 3 to 30% by mass. . When the liquid oil content is too small, the gel is not sufficiently formed and the stability is lowered. When the liquid oil content is too large, stickiness or emulsification stability tends to be deteriorated.
The liquid oil (component (G)) in the present invention is preferably a nonpolar oil such as a hydrocarbon oil or a silicone oil. The nonpolar oil component means that the molecular structure does not contain a hydratable functional group such as an ether bond, an ester bond, an amide bond, a hydroxyl group or a carboxyl group.

As the hydrocarbon oil, liquid paraffin, squalane, squalene, paraffin, isoparaffin, ceresin and the like can be used.
Examples of silicone oils include chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; cyclic silicones such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; Examples thereof include silicone resin and silicone rubber forming a network structure.

In addition to the above, a small amount of polar oil can be blended within a range that does not impair the stability of the composition. Polar oils include liquid oils and ester oils.
Liquid oils include linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, large There are bean oil, peanut oil, triglycerin, glycerin trioctanoate, glycerin triisopalmitate and the like.
Ester oils include cetyl octanoate, hexyl laurate, isopropyl myristate, octyl palmitate, isocetyl stearate, isopropyl isostearate, octyl isopalmitate, isodecyl oleate, glyceryl tri-2-ethylhexanoate, tetra-2-ethyl There are pentaerythritol hexanoate, 2-ethylhexyl succinate, diethyl sebacate and the like.
In the present invention, the component (G) does not include the component (E), which is an essential component, and an amphiphilic substance.

In the oil-in-water emulsion composition of the present invention, a gel is formed with the components (C) to (G), and the gel transition temperature is 60 ° C or higher, preferably 65 ° C or higher. is required. If the gel transition temperature is less than 60 ° C., the temperature stability of the system is lowered, and creaming may occur at a high temperature.
This gel is composed of α-gel. An α-gel is an aggregate formed in water by a higher aliphatic alcohol and a hydrophilic surfactant. The α-structure (Shoji Fukushima, “Physical Chemistry of Cetyl Alcohol”, Fragrance Journal, 1992) Means a gel to take.

  In the oil-in-water emulsion composition of the present invention, since the component (D) to be blended is less than 1% by mass with respect to the total amount of the emulsion composition, the amount of gel formation is small, compared to conventional emulsions or creams. It has a refreshing and light feeling. That is, according to the present invention, when it contains a D-amino acid and a chelating agent that tend to reduce the viscosity of the composition, the stability with time is good despite a small amount of surfactant to be blended, and Thus, it is possible to provide an oil-in-water emulsion composition having good usability.

The oil-in-water emulsified composition of the present invention can produce oil-in-water emulsified compositions mainly used as a skin external preparation for cosmetics, pharmaceuticals, quasi-drugs and the like by a conventional method. It is preferably used as an external preparation for skin which takes the form of an oil-in-water cream form to be formed in principle.
In addition, in the external preparation for skin, depending on the specific purpose, optional components usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, powders, coloring materials, etc., as long as the desired effects of the present invention are not impaired. Water, alcohols, thickeners, silicones, antioxidants (antioxidants), UV absorbers, moisturizers, fragrances, various medicinal ingredients, preservatives, neutralizers, pH adjusters, etc. As long as it does not interfere with the effect, it can be blended as needed.

  Examples of the powder include mica, talc, kaolin, sericite (sericite), muscovite, phlogopite, synthetic mica, saucite, biotite, lithia mica, synthetic mica, calcium carbonate, magnesium carbonate, and anhydrous silicic acid ( Silica), aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, aluminum oxide, barium sulfate, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, oxide Zinc, titanium mica (titanium oxide coated mica), fish phosphorus foil, bismuth oxychloride, boron nitride, red 228, red 226, blue 404, polyethylene powder, polymethyl methacrylate powder, polyamide resin powder (nylon powder) , Cellulose powder, organopolysiloxane elastomer, aluminum Uda, mention may be made of a copper powder and the like.

  Examples of alcohols include lower alcohols such as methanol, ethanol, propanol and isopropanol; cholesterol, sitosterol, lanosterol and the like.

  Examples of thickeners include, for example, plant polymers such as gum arabic, tragacanth cam, galactan, carop gum, guar gum, carrageenan, pectin, agar, starch (corn, wheat, potato, rice), and microorganisms such as dextran and pullulan. Molecules, starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, animal-based polymers such as collagen, casein and gelatin, methylcellulose, nitrocellulose, ethylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, Cellulosic polymers such as crystalline cellulose, alginic acid polymers such as sodium alginate and propylene glycol alginate, polyvinyl methyl ester Vinyl polymer such as tellurium and carboxyvinyl polymer, POE polymer, POE polyoxypropylene copolymer polymer, acrylic polymer such as sodium polyacrylate and polyacrylamide, polyethyleneimine, cationic polymer, bentonite And water-soluble polymers such as inorganic water-soluble polymers such as magnesium aluminum silicate, laponite, hectorite, and silicic anhydride.

  Examples of the ultraviolet absorber include benzoic acid ultraviolet absorbers such as paraaminobenzoic acid; anthranilic acid ultraviolet absorbers such as methyl anthranilate; salicylic acid ultraviolet absorbers such as octyl salicylate; isopropyl paramethoxycinnamate, para Cinnamic acid UV absorbers such as octyl methoxycinnamate; UV absorbers such as urocanic acid and ethyl urocanate; benzophenone UV absorbers such as 2-hydroxy-4-methoxybenzophenone and dihydroxybenzophenone; benzotriazole UV Examples thereof include an absorbent and 2-phenylbenzimidazole-5-sulfonic acid.

  Examples of the humectant include polyethylene glycol (hereinafter referred to as PEG), propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, xylitol, maltitol, maltose, D-mannitol, glucose, Examples include fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, glucosamine, and cyclodextrin.

Examples of medicinal ingredients include vitamin A oil, retinol, retinol palmitate, pyridoxine hydrochloride, benzyl nicotinate, nicotinic acid amide, nicotinic acid dl-α-tocopherol, ascorbic acid magnesium phosphate, vitamin D ₂ , dl-α- Vitamins such as tocopherol, pantothenic acid and biotin; anti-inflammatory agents such as azulene and glycyrrhizin; whitening agents such as arbutin, 4-methoxysalicylic acid, tranexamic acid, ethylvitamin C and magnesium ascorbate, and hormones such as estradiol; Astringents such as zinc oxide and tannic acid; refreshing agents such as L-menthol and camphor; other lysozyme chloride, pyridoxine hydrochloride, sulfur and the like can be added. Furthermore, various extracts showing various medicinal effects can be blended. That is, there can be mentioned, for example, dokudami extract, apricot extract, licorice extract, peony extract, button pi extract, loofah extract, cypress extract, eucalyptus extract, clove extract, maronier extract, cornflower extract, seaweed extract, thyme extract and the like.

  Examples of preservatives include benzoic acid, salicylic acid, paraoxybenzoic acid esters (methylparaben, ethylparaben, butylparaben, etc.), sorbic acid, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide. , Photosensitive element, phenoxyethanol, and the like.

In addition to the above, neutralization of 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, potassium hydroxide, potassium hydroxide, triethanolamine, sodium carbonate, etc. Agents; pH adjusters such as lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, sodium hydrogen carbonate ammonium hydrogen carbonate; antioxidants such as ascorbic acid, α-tocopherol, carotenoids and the like can be blended.
In addition, the said component is an illustration and is not limited to these. Further, these components can be appropriately combined and blended in accordance with a prescription according to a desired form.

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited to these examples. Unless otherwise specified, all the amounts are mass%.
First, the evaluation method used in the present invention will be described.

(Evaluation methods)
An oil-in-water emulsion composition having the composition shown in Table 1 and Table 2 below was prepared, and a sensory test on the presence / absence of odor and discoloration and usability was conducted by a special panel (15 persons), and evaluation was performed according to the following evaluation criteria. The evaluation results are also shown in Tables 1 and 2.

Evaluation criteria for odor:
○: Thirteen or more of 15 people determined that there was no odor △: 10-12 of 15 people judged that there was no odor △: 7-9 of 15 people judged that there was no odor △: 15 people 4-6 of them are judged as having no odor xx: 3 or less of 15 people are judged as having no odor

Evaluation criteria for discoloration:
○: It is determined that 13 or more of 15 people are not discolored. Δ: 10 to 12 of 15 people are determined to be discolored. Δ: 7 to 9 of 15 people are determined to be discolored. Δ ×: 4 to 15 of 15 people are discolored. 6 people judged no discoloration XX: 3 out of 15 people judged no discoloration

Usability evaluation criteria:
○: 13 or more out of 15 people judged as “no sliminess / penetration” ○ △: 10-12 of 15 people judged as “no slimy / penetration” Δ: 7-9 out of 15 Name is judged as “no sliminess / penetration” Δ ×: 4 to 6 out of 15 people are judged as “no slimy / penetration” XX: Three or less of 15 people are “no sliminess” Determined to have a sense of penetration

Evaluation criteria for emulsion stability:
The appearance of the sample after standing for 1 month at 50 ° C. was visually observed and evaluated according to the following evaluation criteria.
(Evaluation criteria)
○: No separation was observed at all.
Δ: Little separation was observed.
X: Separation of the liquid phase (oil phase or water phase) occurred.

  As is clear from the results shown in Tables 1 and 2, the discoloration due to the incorporation of the L-amino acid could be improved by substituting the D-amino acid (Comparative Examples 1 and 2), but further a chelating agent The remarkable odor change and discoloration suppressing effect was obtained by blending (Examples 1 and 2). This effect was not sufficient when the amount of the chelating agent was too small (Comparative Example 3). Moreover, even if it contains a D-amino acid and a chelating agent, Comparative Example 4 in which no POE fatty acid sorbitan (component C) or N-acylmethyl tauric acid (component D) is blended has poor emulsification stability and improves it. Therefore, when a thickener was blended in a large amount, the usability deteriorated (Comparative Example 5).

Hereinafter, other examples of the present invention will be described.
In addition, when the same characteristic evaluation as described above was performed for the following examples, excellent results were obtained in all cases.

Example 3: emulsion component blending amount (mass%)
Purified water Residual ethanol 3
Glycerin 5
Dipropylene glycol 5
Xanthan gum 0.05
POE (20) sorbitan stearate 0.8
N-stearoyl sodium N-methyltaurine 0.15
Behenyl alcohol 0.5
Stearyl alcohol 0.5
Glyceryl tri-2-ethylhexanoate 2
Squalane 2
Dimethylpolysiloxane 2
D-lysine 0.5
Tranexamic acid 2
Citric acid 0.02
Sodium citrate 0.08
Edetate disodium 0.1
Phenoxyethanol 0.5
Perfume

Production method:
The oil-soluble component was dissolved in the oil and then heated to 70 ° C. (oil phase). On the other hand, the water-soluble component was dissolved in purified water and heated to 70 ° C. (aqueous phase). After adding the above-mentioned oil phase to this water phase and stirring and mixing, the mixture was cooled to room temperature to obtain an emulsion.

Example 4: Cream component blending amount (mass%)
Purified water Residual glycerin 10
Butylene glycol 5
POE (20) sorbitan stearate 2.5
N-stearoyl sodium N-methyltaurine 0.15
Behenyl alcohol 3.5
Stearyl alcohol 0.5
Cetyl 2-ethylhexanoate 8
Liquid paraffin 3
Methylphenylpolysiloxane 3
D-arginine hydrochloride 0.5
Potassium 4-methoxysalicylate 1
Dipotassium glycyrrhizinate 0.05
Sodium hexametaphosphate 0.15
Phenoxyethanol 0.5
Perfume

Production method:
The oil-soluble component was dissolved in the oil and then heated to 70 ° C. (oil phase). On the other hand, the water-soluble component was dissolved in purified water and heated to 70 ° C. (aqueous phase). The oil phase described above was added to the aqueous phase, mixed and stirred, and then cooled to room temperature to obtain a cream.

Example 5: Cosmetic liquid ingredient content (mass%)
Purified water Residual glycerin 10
Butylene glycol 5
POE (20) sorbitan stearate 0.8
N-stearoyl sodium N-methyltaurine 0.15
Behenyl alcohol 0.5
Stearyl alcohol 0.5
Cetyl 2-ethylhexanoate 5
Liquid paraffin 3
Dimethylpolysiloxane 3
Glyceryl diisostearate 1
Sodium D-glutamate 0.5
Carnosine 3
Vitamin E derivative 0.05
Edetate trisodium 0.1
Methylparaben 0.15
Perfume

Production method:
The oil-soluble component was dissolved in the oil and then heated to 70 ° C. (oil phase). On the other hand, the water-soluble component was dissolved in purified water and heated to 70 ° C. (aqueous phase). The oil phase described above was added to this water phase, and the mixture was stirred and mixed, and then cooled to room temperature to obtain a cosmetic liquid.

Claims (3)

(A) D-amino acid and / or a salt thereof, (B) a chelating agent, (C) a polyoxyethylene fatty acid sorbitan derived from a linear saturated fatty acid having 14 to 18 carbon atoms, (D) N-acyl A methyl taurine salt, (E) a higher alcohol, (F) water, and (G) an oil that is liquid at room temperature, and a gel having a transition temperature of 60 ° C. or higher is formed with the components (C) to (G). Oil-in-water emulsion composition. The composition according to claim 1, wherein the D-amino acid is selected from D-glutamic acid, D-lysine or D-arginine. The composition according to claim 1 or 2, wherein the chelating agent is one or more selected from ethylenediaminetetraacetic acid, hydroxyethanedisulfonic acid or a salt thereof.