JP2008163006A - Skin cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin cosmetic which is effective to prevent skin aging in a manner that it enhances the moisture holding function of the skin to make the skin less dry and improves rough skin and a skin barrier effect. <P>SOLUTION: The skin cosmetic comprises a hyaluronic acid oligosaccharide and/or a salt thereof, a 5-10C 1,2-alkanediol, desirably 1,2-octanediol, and optionally a collagen peptide, represented by formula (1): (Gly-X-Y)<SB>n</SB>(wherein Gly is a glycine residue; X and Y, which may be the same or different from each other, are each an amino acid residue; and n is an integer), desirably a collagen peptide of a weight-average molecular weight of 100-3,000. Desirably, the hyaluronic acid oligosaccharide is a hyaluronic acid oligosaccharide containing six or smaller constituent sugars. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a skin cosmetic. Specifically, the present invention relates to a skin cosmetic that is excellent in the effect of preventing skin aging.

  Aging skin is a dry, rough and rough skin condition, and in order to improve it, it is necessary to give the skin appropriate moisture and oil. For this reason, hydrophilic skin moisturizers and oily skin softeners have been used for skin cosmetics. However, hydrophilic skin moisturizers such as glycerin and propylene glycol sometimes absorb the moisture in the stratum corneum and cause loss of skin moisture. In addition, oily emollients such as liquid paraffin and petrolatum, when added in an amount that sufficiently suppresses the transpiration of water from the epidermis, may cause stickiness and may inhibit normal skin metabolism. It was.

  Therefore, skin cosmetics (see Patent Document 1) containing ceramides and acidic mucopolysaccharides such as hyaluronic acid having an average molecular weight of 100,000 to 5,000,000, high molecular weight hyaluronic acid having a molecular weight of 1 million or more, molecular weight of 100,000 or less Skin cosmetics containing low molecular weight hyaluronic acid, polyhydric alcohol and edetate (see Patent Document 2), skin cosmetics containing phytosterol, hyaluronic acid or ceramides (see Patent Document 3), γ-amino- Skin anti-aging cosmetics containing β-hydroxybutyric acid and collagen (see Patent Document 4) have been proposed. However, although these effects can improve skin aging prevention effects to some extent, they are still not satisfactory.

Japanese Examined Patent Publication No. 6-96514 Japanese Patent Laid-Open No. 1-190614 JP 2001-10946 A JP-A-6-256159

  The present invention has been made in view of the above-described prior art, and has an excellent skin aging prevention effect of improving dry skin and improving rough skin and skin barrier effect by enhancing the moisture retention function of the skin. It is an object to provide a skin cosmetic.

で表されるコラーゲンペプチドを含有することを特徴とする前記〔１〕又は〔２〕に記載の皮膚化粧料、
〔４〕前記コラーゲンペプチドの分子量が、重量平均分子量で１００〜３０００であることを特徴とする前記〔３〕に記載の皮膚化粧料、並びに
〔５〕１，２−アルカンジオールが、１，２−オクタンジオールであることを特徴とする前記〔１〕〜〔４〕のいずれかに記載の皮膚化粧料
に関する。 That is, the present invention
[1] A skin cosmetic comprising hyaluronic acid oligosaccharide and / or a salt thereof and a 1,2-alkanediol having 5 to 10 carbon atoms,
[2] The skin cosmetic according to [1], wherein the hyaluronic acid oligosaccharide is a hexasaccharide or less hyaluronic acid oligosaccharide,
[3] The following formula (1)

The skin cosmetic according to [1] or [2] above, comprising a collagen peptide represented by
[4] The skin cosmetic according to [3] above, wherein the molecular weight of the collagen peptide is 100 to 3000 in weight average molecular weight, and [5] 1,2-alkanediol is 1,2 -Octanediol It is related with the skin cosmetics in any one of said [1]-[4] characterized by the above-mentioned.

  The skin cosmetic of the present invention has the effect of preventing skin aging, which improves dry skin by enhancing the moisture retention function of the skin, thereby improving rough skin and the skin barrier effect.

  The skin cosmetic of the present invention contains hyaluronic acid oligosaccharide and / or a salt thereof and 1,2-alkanediol.

  The hyaluronic acid oligosaccharide used in the present invention is not particularly limited as long as it can be used in cosmetics. However, since hyaluronic acid has an excellent effect of preventing skin aging, hyaluronic acid having a basic unit of 10 units or less, that is, 20 sugars or less. It is preferable to use an acid oligosaccharide, and it is more preferable to use a hyaluronic acid oligosaccharide having a basic unit of hyaluronic acid of 5 units or less (that is, 10 sugars or less). Among them, it is more preferable to use a hyaluronic acid oligosaccharide having a basic unit of hyaluronic acid of 3 units or less (that is, 6 sugars or less). It is particularly preferable to use it. The basic unit of hyaluronic acid represents a disaccharide in which D-glucuronic acid and N-acetyl-D-glucosamine are glycosidically bonded.

  Hyaluronic acid oligosaccharides can be obtained by various known methods. For example, commercially available high molecular weight hyaluronic acid can be produced by enzymatic decomposition, acid decomposition, base decomposition, heat treatment, ultrasonic treatment or the like. Moreover, you may manufacture by chemical synthesis.

  For example, when hyaluronic acid oligosaccharides are produced by an enzymatic degradation method, the methods disclosed in International Publication No. 2002/4471 pamphlet and Glycobiology, 2002, Vol. 12, No. 7, pages 421-426 are used. It can be manufactured similarly. That is, high molecular weight hyaluronate is dissolved in a buffer solution (for example, 0.1 M phosphate buffer solution) so that the pH of the solution is around 5, and then hydrolyzed by adding hyaluronidase. The hydrolysis temperature is preferably around 37 ° C., and is allowed to react for about 1 to 24 hours, preferably about 5 to 15 hours. After the reaction, the supernatant can be recovered by centrifugation at about 10,000 rpm, and the supernatant can be obtained by fractionation using an ion exchange column or the like.

  When producing hyaluronic acid oligosaccharides by acid hydrolysis, for example, after reacting high molecular weight hyaluronate in a 50% aqueous solution of concentrated hydrochloric acid at 40 ° C. to reflux temperature for about 1 to 5 hours, an ion exchange column, etc. Can be obtained by fractionation. Moreover, it can also hydrolyze on the milder conditions heated using about 0.05-1M hydrochloric acid in solvents, such as DMSO.

  Examples of the hyaluronic acid oligosaccharide salt include sodium salt, potassium salt, triethanolamine salt and the like, but sodium salt is preferably used.

  The content of the hyaluronic acid oligosaccharide and / or salt thereof is not particularly limited as long as the effect of the present invention is exhibited, and is preferably 0.01% by weight or more in the cosmetic from the viewpoint of exerting the desired effect. Preferably it is 0.1 weight% or more. Further, in terms of good usability, the content in the cosmetic is preferably 10% by weight or less, more preferably 5% by weight or less. From these, 0.01-10 weight% is preferable and, as for content in skin cosmetics, 0.1-5 weight% is more preferable.

  As the 1,2-alkanediol used in the present invention, 1,2-alkanediol having 5 to 10 carbon atoms is used. Specific examples include 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, and 1,2-decanediol. Of these, it is preferable to use 1,2-octanediol. In the present invention, one of these may be used alone, or two or more may be used in appropriate combination.

  The content of 1,2-alkanediol is not particularly limited as long as the effects of the present invention are exhibited. From the viewpoint of exerting the desired effects, the content is preferably 0.05% by weight or more, more preferably 0. .1% by weight or more. Further, in terms of good usability, the content in the cosmetic is preferably 10% by weight or less, more preferably 5% by weight or less. From these, 0.05-10 weight% is preferable and, as for content in skin cosmetics, 0.1-5 weight% is more preferable.

で表されるペプチドである。なかでも、重量平均分子量が１００〜３０００のコラーゲンペプチドを用いるのが好ましく、重量平均分子量が５００〜２０００のコラーゲンペプチドを用いるのがより好ましい。 In the present invention, a collagen peptide can be contained in order to further improve the effect of preventing skin aging. The collagen peptide is composed of a collagen tripeptide represented by Gly-XY (wherein Gly represents a glycine residue and X and Y represent amino acid residues which may be the same or different from each other). The following formula (1)

It is a peptide represented by these. Especially, it is preferable to use the collagen peptide whose weight average molecular weight is 100-3000, and it is more preferable to use the collagen peptide whose weight average molecular weight is 500-2000.

  The origin of the collagen used as the raw material for the collagen peptide is not particularly limited, and examples thereof include animals, fish, shellfish, jellyfish, and sponges.

  Specifically, beef such as cattle and pigs; flounder, flatfish, skipjack, shark, ray, mackerel, saury, horse mackerel, sardine, salmon, tilapia, tuna, cod, halibut and other fish; mussel, pearl oyster, scallop, warbler Examples include shellfish such as oysters, oysters; jellyfishes such as moon jellyfish, octopus jellyfish, red jellyfish, jellyfish jellyfish, bizen jellyfish, northern jellyfish, echidella jellyfish; sponges such as common sponge, lime sponge, bone-bone sponge, and six-band sponge can do.

  Extraction of collagen is not particularly limited, and can be performed by a known method. For example, it can be obtained by chopping fish skin, fish bones, fish scales and the like and extracting them with ethanol, water, sodium chloride solution or the like.

  The collagen peptide can be prepared by allowing collagenase to act on collagen. The method for preparing the collagen peptide is not particularly limited, and can be performed by a known method. For example, collagenase immobilized on an immobilization carrier can be produced at a reaction temperature of 40 to 45 ° C. by a batch method, a column method, or a combination thereof. The collagenase used at this time is a glycine having an amino acid sequence unique to collagen [Gly-XY (where Gly represents a glycine residue, and X and Y represent amino acid residues which may be the same or different from each other)]. It is preferable to use a collagenase that specifically cleaves the amino terminal side of the residue.

  In order to obtain a collagen peptide having a specific average molecular weight, fractionation may be performed by a known fractionation method. For example, fractionation can be performed by gel filtration or chromatography.

  In addition, the collagen peptide can also utilize a commercial item as it is. Commercially available products that can be used in the present invention include, for example, trade name collagen tripeptide (manufactured by Miyagi Chemical Co., Ltd.), trade name collagen tripeptide (manufactured by Ihara Suisan Co., Ltd.), trade name Falconics CTP (BG) (Ichimaru Falcos) Etc.).

  The content of the collagen peptide is not particularly limited as long as the effects of the present invention are exhibited. From the viewpoint of exhibiting the desired effects, the content in the cosmetic is preferably 0.01% by weight or more, more preferably 0.1% by weight. That's it. Further, in terms of good usability, the content in the cosmetic is preferably 10% by weight or less, more preferably 5% by weight or less. From these, 0.01-10 weight% is preferable and, as for content in skin cosmetics, 0.1-5 weight% is more preferable.

  In the skin cosmetic of the present invention, as long as it does not impair the effects of the present invention, in addition to the above-described components, components usually used in cosmetics and quasi-drugs can be arbitrarily arbitrarily blended. For example, oily components such as fats and oils, waxes, hydrocarbons, silicones, fatty acid esters, higher alcohols, higher fatty acids, etc .; various types of nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants Surfactants; alcohols such as lower alcohols, polyhydric alcohols, saccharides and sterols; thickening polymers such as viscosity minerals and water-soluble polysaccharides; ultraviolet absorbers; humectants; antioxidants; sequestering agents; Examples include film forming polymer compounds, inorganic pigments, powders, pigments, pigments, dyes, vitamins, amino acids, astringents, whitening agents, animal and plant extracts, acids, alkalis, and the like; water and the like. it can.

  Specifically, examples of the oil component include oils and fats such as olive oil, camellia oil, macadamia nut oil and avocado oil; waxes such as carnauba wax, candelilla wax, jojoba oil, beeswax and lanolin; liquid paraffin, paraffin, petrolatum, Hydrocarbons such as ceresin, microcrystalline wax, squalene, squalane; methylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, octamethylcyclopentasiloxane, decamethylcyclopentasiloxane, methylhydrogenpoly Silicones such as siloxane; isopropyl myristate, 2-octyldodecyl myristate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, di-2-ethylhexane Neopentyl glycol, glycerol tri-2-ethylhexanoate, 2-octyldodecyl oleate, glycerol triisostearate, glycerol tri-2-ethylhexanoate, 2-octyldodecyl oleate, diisostearyl malate, triisostearic acid Fatty acid esters such as glycerol and 2-ethylhexanoic acid diglyceride; higher alcohols such as cetyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol, and oleyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid And higher fatty acids such as acid and oleic acid.

  Surfactants include sorbitan fatty acid ester, glycerin fatty acid ester, castor oil, hydrogenated castor oil, and alkylene oxide adducts thereof, polyglycerin fatty acid ester, polyoxyalkylene alkyl ether, polyoxyalkylene fatty acid ester, polyoxyalkylene alkylphenol. Nonionic surfactants such as polyoxyethylene sorbite fatty acid ester, polyoxyethylene alkylphenyl formaldehyde condensate, polyoxyethylene sterol and derivatives thereof, polyoxyethylene lanolin and derivatives thereof, polyoxyethylene beeswax derivatives and sugar esters; Higher fatty acid soap, alkyl sulfate ester salt, alkyl phosphate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl Phenyl ether sulfate, alkyl ether phosphate, alkyl ether carboxylate, acylmethyl taurate, N-acyl-N-methyl-β-alanine, N-acyl glycine, N-acyl glutamate, polyoxyethylene Anionic surfactants such as alkyl carboxylates, alkyl phenyl ether sulfonates, alkyl sulfosuccinic acids and salts thereof, N-acyl sarcosine and salts thereof, polyoxyethylene coconut oil fatty acid monoethanolamide sulfate; alkylamine salts; Alkyl 4 such as fatty acid amide amine salt, amine salt such as ester-containing tertiary amine salt, monoalkyl type quaternary ammonium salt, dialkyl type quaternary ammonium salt, trialkyl type quaternary ammonium salt, benzalkonium type quaternary ammonium salt Grade ammonium salt Cyclic quaternary ammonium salts such as alkylpyridinium salts, cationic surfactants such as benzethonium chloride; glycine types such as alkylglycine salts, carboxymethylglycine salts, N-acylaminoethyl-N-2-hydroxyethylglycine salts Amphoteric surfactants, aminopropionic acid type amphoteric surfactants such as alkylaminopropionate and alkyliminodipropionate, aminoacetic acid betaine type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine And amphoteric surfactants such as sulfobetaine-type amphoteric surfactants such as agents and alkylhydroxysulfobetaines.

  Examples of alcohols include lower alcohols such as ethanol, isopropanol, and butanol; polyhydric alcohols such as 1,3-butanediol, glycerin, polyglycerin, ethylene glycol, polyethylene glycol, and polypropylene glycol; sorbitol, mannitol, glucose, Examples thereof include saccharides such as sucrose, xylitol, lactose and trehalose; and sterols such as cholesterol and phytosterol.

  As the thickening polymer, for example, bentonite, smectite, beidellite-based, nontronite-based, saponite-based, hectorite-based, soconite-based, stevensite-based viscous minerals; carrageenan, guar gum, xanthan gum, gum arabic, Examples include karaya gum, tragacanth gum, dextran, amylose, amylopectin, agarose, pullulan, chondroitin sulfate, sodium pectate, alginic acid, methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and the like.

  Examples of the ultraviolet absorber include benzoic acid-based ultraviolet absorbers such as paraaminobenzoic acid and paraaminobenzoic acid monoglycerin ester; anthranilic acid-based ultraviolet absorbers such as methyl anthranilate and homomenthyl-N-acetylanthranilate; methyl salicylate Salicylic acid UV absorbers such as octyl paramethoxycinnamate and ethyl-4-isopropylcinnamate; benzophenone UV absorbers such as 2,4-dihydroxybenzophenone; amyl salicylate and menthyl Examples include salicylic acid ultraviolet absorbers such as salicylate and benzyl salicylate; urocanic acid ultraviolet absorbers such as urocanic acid and ethyl urocanate.

  Examples of the humectant include polyhydric alcohols such as ethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, 1,3-butylene glycol, glycerin and polyglycerin; glucose, maltose, maltitol, scroll, mannitol, sorbitol, Sugars such as xylitol; sugar derivatives such as polyoxyethylene methyl glucoside and polyoxypropylene methyl glucoside; polysaccharides such as dextrin and chondroitin sulfate; amino acids such as glycine, alanine, serine, arginine and glutamic acid; sodium citrate and sodium lactate And organic acid salts such as sodium malate.

  Examples of the antioxidant include α-tocopherol and its derivatives, ascorbic acid and its derivatives, erythorbic acid, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters, sulfurous acid, bisulfite, thiosulfuric acid, thiolactic acid, thioglycol An acid, L-cysteine, N-acetyl-L-cysteine, etc. can be mentioned.

  Examples of the sequestering agent include edetate, phosphoric acid, sodium polyphosphate, sodium metaphosphate, alanine, sodium oxalate, nitrilotriacetic acid, 1,2-diaminocyclohexane-tetraacetic acid, N-oxyethylethylenediamine- Triacetic acid, ethylene glycol bis-tetraacetic acid, ethylenediamine-tetrapropionic acid, 1-hydroxyhexane-1,1-diphosphonic acid, phosphonoacetic acid, diethylenetriaminepentaacetic acid, 1,2-cyclohexanediaminetetraacetic acid, ethylenediaminediacetic acid, triethylene Examples thereof include tetramine hexaacetic acid.

  The skin cosmetics of the present invention can be used as cosmetics such as cosmetics and quasi drugs. Specifically, it can be suitably used for lotion, milky lotion, skin cream, cosmetic liquid, facial cleanser, after-shave lotion and the like.

  EXAMPLES Hereinafter, although this invention is demonstrated further in detail based on an Example, this invention is not limited only to this Example. The content represents “% by weight” unless otherwise specified. POE is an abbreviation for polyoxyethylene, and the added mole number of POE is shown in parentheses.

(Sample preparation)
Hyaluronic acid oligosaccharide was prepared according to the method of International Publication No. 2002/4471 pamphlet. That is, 10 g of sodium hyaluronate was added to 450 mL of 100 mM phosphate buffer (pH 5.3), stirred, 80 mg of hyaluronidase was added, and enzymatic degradation was performed at a constant temperature of 37 ° C. for 24 hours. The supernatant of the obtained reaction solution was collected with a centrifuge (10000 rpm, 30 minutes), and sodium chloride was added to a column packed with strongly basic ion exchange resin type I (trade name Dowex 1 × 2, manufactured by Dow Chemical Co.). The aqueous solution was fractionated as an eluent. The desired fraction was desalted and lyophilized to obtain 1.6 g of hyaluronic acid oligosaccharide. As a result of analyzing the obtained hyaluronic acid oligosaccharide by gel filtration chromatography, as a hyaluronic acid oligosaccharide having a purity of about 80% as a hyaluronic acid oligosaccharide of 6 sugars or less and a hyaluronic acid oligosaccharide of 4 sugars or less from a relative peak area of 210 nm. The purity was about 60%.
Using the hyaluronic acid oligosaccharide obtained above, according to the composition described in Table 1, lotions of Examples and Comparative Examples were respectively prepared by conventional methods and subjected to the following evaluation. In addition, the compounding quantity in each table | surface is "weight%."

[Test Example 1; rough skin improvement effect test]
About 1 mL of each sample of Examples and Comparative Examples was applied twice a morning and evening to 10 subjects suffering from rough skin continuously for 4 weeks, and the effect of improving rough skin was evaluated with the naked eye based on the following evaluation criteria. In addition, the average value of each test subject was employ | adopted for the evaluation result. The results are also shown in Table 1.

<Evaluation criteria>
A: There was no desquamation, and the skin was improved.
○: Improved to almost normal skin.
Δ: Slightly improved.
X: Clearly there is desquamation and it has not been improved at all.

[Test Example 2: Skin moisturizing effect test]
The skin moisturizing effect of each sample of Examples and Comparative Examples was evaluated by 10 subjects. That is, the face of each subject was washed with warm water using a facial cleanser and allowed to rest in a constant temperature and humidity chamber at a temperature of 20 ° C. and a humidity of 50% for 15 minutes. It measured with the water | moisture content amount measuring apparatus (SKICON-200EX type; made by IB S). The measurement is to measure the initial value of the moisture content of the skin, and after 30 minutes, the samples of Examples and Comparative Examples are applied, and after 30 minutes, 3 hours and 6 hours after application, the moisture content of each skin is measured. The average value was adopted. The results are shown in FIG.

[Test Example 3: Skin barrier recovery effect test]
The skin barrier recovery effect of each sample of Examples and Comparative Examples was evaluated by 10 subjects. That is, the percutaneous moisture transpiration (TEWL) of the inner side of the forearm of the test subject was measured with a skin moisture transpiration measuring device (TEWAMETER TM210 type; manufactured by Curage + Khazaka electronic). The TEWL value (T ₁ ) was 100%. Next, the skin barrier was broken by tape stripping the inner part of the forearm, and TEWL was measured in the same manner. The TEWL value (T ₀ ) was set to 0%.

Thereafter, each sample of Examples and Comparative Examples was applied to the tape stripped part once a day after bathing, and continued for 14 days, and then TEWL was measured. The TEWL value (T ₂ ) was converted to a percentage, the TEWL recovery rate was determined from the following formula, and the average value was adopted. The results are also shown in Table 1.

TEWL recovery rate (%) = [(T ₂ −T ₀ ) / (T ₁ −T ₀ )] × 100

  From the results shown in Table 1 and FIG. 1, the skin cosmetic of the present invention improves the moisture retention function of the skin, improves rough skin and the stratum corneum, and keeps the skin in a healthy state, thereby exhibiting an effect of preventing skin aging. I understand that.

  Hereinafter, formulation examples of skin cosmetics according to the present invention will be shown. In addition, a compounding quantity is weight%.

(Formulation example 1; emollient lotion)
Vaseline 2.0
Squalane 5.0
Sorbitan sesquioleate 0.8
Polyoxyethylene oleyl ether (20E.O.) 1.5
1,2-octanediol 0.1
Collagen peptide (average molecular weight 1500) 1.0
Hyaluronic acid oligosaccharide (2-4 sugars) 1.0
Carboxyvinyl polymer 0.16
Potassium hydroxide 0.1
Methylparaben 0.3
Perfume appropriate amount UV absorber appropriate amount
Purified water residue Total 100.0

(Formulation example 2; emollient lotion)
Liquid paraffin 15.0
Beeswax 2.0
Lanolin 1.5
Sorbitan sesquioleate 2.5
Polyoxyethylene sorbitan monooleate 1.0
1,2-hexanediol 1.0
1,2-octanediol 0.05
Collagen peptide (average molecular weight 1500) 0.5
Hyaluronic acid oligosaccharide (2-4 sugars) 0.3
Propylene glycol 3.0
Perfume appropriate amount UV absorber appropriate amount
Purified water residue Total 100.0

(Formulation example 3; emollient cream)
Stearyl alcohol 5.0
Stearic acid 2.0
Vaseline 5.0
Squalane 5.0
Glyceryl tri-2-ethylhexanoate 1.0
Jojoba oil 1.0
Olive oil 1.0
Dipropylene glycol 4.0
1,2-pentanediol 3.0
1,2-octanediol 0.05
Collagen peptide (average molecular weight 3000) 1.0
Hyaluronic acid oligosaccharide (tetrasaccharide) 0.1
Propylene glycol monostearate 2.5
Polyoxyethylene cetyl ether 3.0
Triethanolamine 1.0
Methylparaben 0.15
Propylparaben 0.1
Perfume appropriate amount Antioxidant appropriate amount
Purified water residue Total 100.0

(Formulation example 4: massage cream)
Solid paraffin 5.0
Beeswah 8.0
Vaseline 8.0
Liquid paraffin 30.0
Glyceryl tri-2-ethylhexanoate 1.0
Jojoba oil 1.0
Olive oil 1.0
1,2-octanediol 0.15
Collagen peptide (average molecular weight 3000) 2.0
Hyaluronic acid oligosaccharide (average molecular weight 2-4 sugar) 0.1
Polyoxyethylene sorbitan monolaurate 2.0
Glyceryl monostearate 1.6
Methylparaben 0.15
Propylparaben 0.15
Perfume appropriate amount Antioxidant appropriate amount
Purified water residue Total 100.0

It is a figure showing the test result of a skin moisturizing effect.

Claims (5)

  A skin cosmetic comprising hyaluronic acid oligosaccharide and / or a salt thereof and 1,2-alkanediol having 5 to 10 carbon atoms.   The skin cosmetic according to claim 1, wherein the hyaluronic acid oligosaccharide is a hexasaccharide or less hyaluronic acid oligosaccharide. Following formula (1)

The skin cosmetic according to claim 1, comprising a collagen peptide represented by the formula:   The skin cosmetic according to claim 3, wherein the collagen peptide has a weight average molecular weight of 100 to 3,000.   The skin cosmetic according to any one of claims 1 to 4, wherein the 1,2-alkanediol is 1,2-octanediol.

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