JP2007039420A - Highly stable agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To improve the stability of a rodenticide by compounding an anticoagulant as an active component to cereal flour containing oil-and-fat such as wheat flour. <P>SOLUTION: The method for stabilizing an active component of a rodenticide comprises the addition of a stabilizing agent composed of 4 kinds of catechins consisting of epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate extracted from the tea prepared e.g. from the leaf of a plant of the family Theaceae and an antioxidant such as BHA. A rodenticide is prepared by using the stabilizing method. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

The present invention relates to a method for stabilizing an active ingredient of a rodenticide, and more particularly to a rodenticide prepared by blending and adjusting an anticoagulant as an active ingredient in a cereal powder containing fats and oils such as wheat flour.

The rodenticide is prepared as a poison that mixes the poisonous and deleterious substances, which are active ingredients, with the food of frogs, and is used to control rats.

There are agrochemicals used in agricultural land and quasi-drugs used in households and the like, depending on the range used.

In addition, there are various forms of preparations, such as powders, grains coated with active ingredients, hardened with wax, etc., flour and sugar kneaded with active ingredients and baked To do. Since these rodenticides are effective not only for mice but also for mammals including humans, it is stipulated by the law that pigments and anticorrosive agents are mixed for the purpose of preventing accidental eating.

Although the history of rodenticides has been long and once used to be quite toxic, the danger of misuse has been recognized and mild formulations with relatively low toxicity have come to be preferred.

There are various active ingredients used in rodenticides. Among them, the most widely used is an anticoagulant, that is, a rodenticide containing an organic compound with an anticoagulant or anticoagulant action. . Coumarin-based warfarin is the most famous among them, and mice die in about 10 days due to internal bleeding when they eat small amounts of a killer containing 0.1% of warfarin continuously. The problem with this component is that it does not die after a single ingestion, if it is not taken continuously, the days to death are increased, and a rat with resistance to warfarin is produced.

For this reason, research on new ingredients that are easy to accumulate in the body of a mouse with a small amount of ingestion and kill in a shorter time is underway, and ingredients such as coumatetralyl, chlorofacinone, difacsinone, bromadiolone, brodifacom are developed in each country, Have been used.

These active ingredients have been studied to have a lethal effect on rats at lower concentrations and in a shorter period of time. In particular, difacsinone, bromadiolone, brodiffacom, etc. have a 0.005% or 50 ppm content in the formulation. At least, rats will be killed in a shorter period of time than warfarin.

However, since the content in the preparation is extremely small, it is easily affected by physical and chemical influences of various factors and may lack stability in the preparation. Patent document 1 aims at stabilization of an active ingredient.

JP 2005-104861 A In the sense of stabilizing the active ingredient, there is naturally a stabilization technique based on the idea of coating the active ingredient. (Patent Documents 2 to 4) JP 63-192701 A JP-A-2002-149501 Special Japanese Showa 61-17801 However, as a general problem, productivity drops and product prices increase, rodents that don't eat rats don't play the role of rodents, even if you eat them, they aren't killed if they are discharged without being digested, etc. Can be given.

When manufacturing a rodenticide, the active ingredient which is an organic compound is added to the flour containing the fats and oils which a mouse likes, and it granulates, and what was formed into a product will decompose | disassemble an active ingredient with progress of time. Conventionally, an oxygen scavenger is used to withstand long-term storage and distribution. However, these conventional methods are still insufficient to withstand long-term storage, and a reduction in productivity cannot be avoided.

The present invention provides a drug in which an active ingredient is easily stabilized for a long period of time without causing a decrease in productivity, such as attaching an oxygen scavenger when filling a product as in the above method, and a method for producing the same.

As a result of earnest research and development on the method for producing the above-mentioned drug, the present inventors have formulated a combination of catechins and antioxidants when using cereal flour containing fats and oils. Gained the knowledge of keeping In other words, according to the regular method, when blending cereal flour and active ingredients, catechins and antioxidants are added and manufactured as a drug, which is 4-5 times compared to additive-free products or catechin-only products. During this period, the stability of the active ingredient can be maintained.

The active ingredient of the rodenticide that can be used in the present invention is a coumarin-based compound, for example, warfarin, coumarin, coumatetralyl, etc., and the indandione-based compound, for example, chlorofacinone, difacsinone, pindon, baron, etc., triaryl-based compounds Examples thereof include difetialone, diphenacum, brodiffacom, bromazirone, furocumafen and the like. These active ingredients can be blended in the preparation from 0.0001% to 1% depending on the use and type.

In the present invention, wheat flour, corn flour, soybean flour, raw nutka, crushed peanuts, peanuts, etc. can be used as cereal flour containing fats and oils, but cereal flour containing fats and oils can also be used. .

The catechins used in the present invention are catechins listed in the existing additive list of food additives, and any catechin can be used as long as it conforms to the standard. The component is a mixture of catechin, epigallocatechin, catechin gallate, epigallocatechin gallate. The catechins can be added in an amount of 0.006 to 0.020% by weight, preferably 0.008 to 0.013% by weight, in the preparation of the rodenticide.

In addition, as the antioxidant used in the present invention, any fat-soluble antioxidant used as a food additive can be used, but butylhydroxyanisole (BHA) is particularly effective. Antioxidant (butylhydroxyanisole) is added to the preparation in an amount of 0.01 to 0.04% by weight, preferably 0.02 to 0.03% by weight.

The rodenticide is blended with an eating agent, a binder, an antiseptic, a pigment, an anticorrosive agent, and the like. As a edible agent, saccharides, fish meal, starch, etc. can be added in addition to cereal flour containing fats and oils.

According to the present invention, the active ingredient can be prevented from being decomposed for a long period of time, and the manufacturing cost can be reduced, the product cycle can be extended, and the resources can be effectively used.

Hereinafter, the best mode for carrying out the present invention completed based on the above knowledge will be described. First, cereal powder containing fats and oils, active ingredients, catechins and antioxidants are charged into a kneader and stirred. Then add water and smelt. The kneaded product is formed into a plate shape by a rolling mill. Next, it is cut into granules using a cutter, dried by heating, filled into a suitable container, and sealed to obtain a finished product.

Examples are shown below, but are not limited thereto.
Add 62.38 kg of wheat flour, 5 kg of sugar, 32.375 kg of corn flour, 0.02 kg of sodium dehydroacetate, 0.005 kg of difacsinone (active ingredient), 0.01 kg of catechins, 0.02 kg of butylhydroxyanisole to the kneader. Stir and mix for a minute. Subsequently, 3 liters of water in which 0.2 kg of polyvinyl alcohol is dissolved is added and smelted for 20 minutes. Next, it is rolled, cut, dried at 150 ° C. for 30 minutes, filled into a suitable container, and sealed to obtain a finished product. Comparative formulations without the addition of stabilizers such as catechins and butylhydroxyanisole are produced in the same manner. Table 1 shows the residual ratio of the active ingredient over time when the drug (finished product and comparative prescription product) is left in an environment of 40 ° C. and 75% humidity.

本試験条件の１ヶ月間は室温に放置した際の１年間に相当する。

One month of this test condition corresponds to one year when left at room temperature.

Claims (4)

  Method for stabilizing active ingredient of rodenticide containing anticoagulant as active ingredient, and rodenticide using the stabilization method   The method for stabilizing an active ingredient according to claim 1 and a rodenticide using the method, wherein both a catechin and an antioxidant are added and mixed as a stabilizer.   The catechins according to claim 2 are extracted from tea made from leaves of Camellia sinensis O. KZE., And the components thereof are epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate. A rodenticide characterized by containing four species   An antioxidant according to claim 2, wherein the antioxidant is butylhydroxyanisole (BHA).