JP2007008847A - Cosmetics - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic material excellent in wrinkle improving effect.
The following components (A) and (B):
(A) General formula (1):
Fru-A-B-R (1)
(In the formula, Fru represents a fructosyl residue, A and B represent amino acid residues, and R represents a hydroxyl group in the C-terminal carboxyl group of the amino acid residue or a methyl esterified group thereof)
Fructosyl dipeptide represented by or salt thereof 0.00001-5 mass%,
(B) Antioxidant and / or anti-inflammatory substance 0.00001-30 mass%
Containing cosmetics.
[Selection figure] None

Description

  The present invention relates to a cosmetic excellent in wrinkle improvement effect.

Maintaining healthy and beautiful skin is a very interesting issue, especially for women. However, the skin condition is always influenced by factors such as humidity, ultraviolet rays, cosmetics, aging, illness, stress, and eating habits. As a result, various skin problems such as deterioration of skin functions and skin aging are caused. appear.
Among these, wrinkles are caused by skin aging due to aging, photoaging due to exposure to sunlight, and the like. That is, the number of cells (fibroblasts) that make dermal fibers becomes smaller and fewer due to exposure to sunlight and an increase in age. In particular, collagen fibers are greatly lost or affected by a decrease in tension, so the dermis is degenerated and the skin is aged due to a decrease in subcutaneous adipose tissue. It is said that it causes generation of elasticity and loss of elasticity.

Conventionally, various compositions and methods have been studied in order to suppress and treat wrinkles and improve skin firmness. For example, techniques for growing dermal tissue using retinoids, retinoic acid, etc. to improve wrinkles are known (Patent Document 1, Patent Document 2, Patent Document 3, etc.). In addition, attempts to improve wrinkles have been made by blending collagen or hyaluronic acid (Patent Document 4, Patent Document 5, etc.), ascorbic acid derivatives (Patent Document 6, etc.), vitamin E (Patent Document 7, etc.). Attempts have also been made to improve wrinkles with compounds such as γ-aminobutyric acid derivatives (Patent Document 8, etc.). However, in these compositions, the effect of improving elasticity and wrinkles is not sufficient, and a higher effect has been desired.
Japanese Unexamined Patent Publication No. 62-185005 JP-A-2-288822 Japanese Patent Laid-Open No. 6-24958 Japanese Patent Publication No.33-500 Japanese Patent Publication No. 4-65047 JP 61-30510 A Japanese Patent Laid-Open No. 62-19511 JP-A-62-255405

  The objective of this invention is providing the cosmetics excellent in the effect which improves the wrinkle of skin.

  The present inventors have found that a cosmetic having an excellent wrinkle improving effect can be obtained by using a fructosyl dipeptide derivative in combination with an antioxidant or an anti-inflammatory substance.

The present invention includes the following components (A) and (B):
(A) General formula (1):
Fru-A-B-R (1)
(In the formula, Fru represents a fructosyl residue, A and B represent amino acid residues, and R represents a hydroxyl group in the C-terminal carboxyl group of the amino acid residue or a methyl esterified group thereof)
Fructosyl dipeptide represented by or salt thereof 0.00001-5 mass%,
(B) Antioxidant and / or anti-inflammatory substance 0.00001-30 mass%
Is provided.

  The cosmetic of the present invention is excellent in the effect of improving wrinkles.

  The fructosyl dipeptide of component (A) used in the present invention is represented by the general formula (1). In the formula, the fructosyl residue represented by Fru may be D-form or L-form, α-form or β-form, and may be either furanose type or pyranose type. In the solution, the α-form, β-form, furanose type, and pyranose type are mutually converted, so that a mixture thereof is obtained.

A and B each represent an amino acid residue, A is a valine residue (Val) or isoleucine residue (Ile), B is a tyrosine residue (Tyr), a phenylalanine residue (Phe), a valine residue (Val) or isoleucine residue (Ile) is preferred. Furthermore, preferable combinations of AB include Val-Tyr, Ile-Tyr, Val-Phe, Ile-Val, Val-Ile and the like.
The steric configuration of each amino acid residue may be either D-form or L-form, but is preferably L-form.

Among the fructosyl dipeptides of component (A), the following are particularly preferable compounds.
Fru-Val-Tyr-OH (Compound A), Fru-Ile-Tyr-OH (Compound B), Fru-Val-Phe-OH (Compound C), Fru-Val-Tyr-OCH3 (Compound D), Fru- Ile-Val-OH (Compound E), Fru-Val-Ile-OH (Compound F).

Examples of the salt of fructosyl dipeptide include alkali metal salts, alkaline earth metal salts, amine salts, amino acid salts, acid addition salts, and the like, preferably alkali metal salts or amino acid salts.
The fructosyl dipeptide or a salt thereof may be in the form of a hydrate.

The (A) fructosyl dipeptide or a salt thereof used in the present invention can be extracted and separated from ginger (Zingiber officinale Roscoe) of Zingiberaceae, and can also be produced by chemical synthesis.
Extraction and separation from ginger can be performed by separating and purifying an extract obtained by extracting ginger rhizomes with a chromatograph. Solvents used for extraction include water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as propylene glycol and butylene glycol; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; Chain and cyclic ethers such as tetrahydrofuran and diethyl ether; Halogenated hydrocarbons such as dichloromethane; Hydrocarbons such as hexane, cyclohexane and petroleum ether; Aromatic hydrocarbons such as toluene; Polyethers such as polyethylene glycol Pyridines and the like, and these can also be used as a mixture. In particular, water or water-containing alcohol is preferably used, and water-containing alcohol having an alcohol concentration of 70% (v / v) or less, particularly 30% (v / v) or less, and further 20% (v / v) is more preferable.

  Chromatographs used for separation and purification include adsorbents such as HP-20 manufactured by Mitsubishi Chemical, reverse phase chromatography such as ODS, normal phase chromatography such as silica gel, and gel filtration chromatographs such as Sephadex LH-20 manufactured by Pharmacia. And cation or anion exchange chromatography. These chromatographs may be combined or used alone.

Many methods for obtaining ginger extract from ginger have been known so far, but ginger extract obtained by a conventional production method (JP 2000-319189 A, etc.) has various color and odor-causing substances. It is a mixture of ingredients, the appearance is yellow to brown, and the smell is unique from ginger. Furthermore, since the color becomes darker with time and the odor deteriorates, it has been difficult to blend in large quantities as a raw material for a composition to be applied to the skin.
However, the fructosyl dipeptide isolated from ginger or a salt thereof used in the present invention is substantially free of odor-causing substances such as gingivalene, is colorless and odorless, and has extremely high solubility in water. It is possible to provide a composition having a high wrinkle-improving effect without any change in color and odor over time and without affecting the blendability of other components used in combination. In the present invention, when fructosyl dipeptide extracted or separated from ginger or a salt thereof is used, it is preferable to use one having a purity of 60% or more, particularly 95% or more.

  Moreover, when manufacturing fructosyl dipeptide by a synthesis | combination, it can manufacture by dehydrating-condensing a corresponding dipeptide and glucose on basic conditions.

  One or more kinds of the fructosyl dipeptide of the component (A) or a salt thereof can be used, and the total composition is 0.00001 to 5% by mass, preferably 0.0003 to 0.1% by mass, more preferably 0. .0003-0.01 mass% is contained.

  Among the components (B) used in the present invention, examples of the antioxidant include α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isozeaxanthin, rhodoxanthin, crocetin, 1 , 4-diazadichlorooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol , Tocotrienol, dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid and its derivatives, tannic acid, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, isoflavone, rutin, α-lipoic acid, ubiquinone, azulene , Β-glucan, caffeic acid, carnosic acid, ethyl vanillin, farnesol, folic acid, hesperidin, kinetin, kojic acid, linolenic acid, mannitol, phytic acid, pullulan, pycnogenol, pyridoxine hydrochloride, saponins, selenium, squalene, thiotaurine And thiazolidinecarboxylic acid.

  Moreover, as an antioxidant, plant extracts having an antioxidant action, for example, extracts of licorice, tomato, yukinoshita, juyu, horsetail, melissa, olive, grape and the like can be used. As these plant extracts, one or more of an extract extracted from each plant by a conventional method or a commercially available product can be used.

  Among the components (B), examples of the anti-inflammatory substance include allantoin, lysozyme chloride, guaiazulene, γ-oryzanol, glycyrrhetinic acid, stearyl glycyrrhetinic acid, glycyrrhizic acid and its salt, tranexamic acid and its derivative, epsilon aminocaproic acid and the like. It is done.

  Anti-inflammatory substances include plant extracts having anti-inflammatory effects, such as chamomile, peonies, peas, tea, toki, peach, amacha, asunaro, arnica, ginkgo, ginseng, turmeric, laurel, hypericum, Dutch mustard, kumazasa, Gentiana, Kojiso, Comfrey, Salvia, Hawthorn, Salamander, Perilla, Zujak, Achillea millefolium, Atlantic mint, Sawbowl, Thyme, Clove, Buttercup, Parsley, Hamamelis, Biwa, Butcherbloom, Bodaiju, Mannenrou, Buttonpi, Cornflower Extracts such as lavender, roman chamomile and dokudami can also be used. As these plant extracts, one or more of an extract extracted from each plant by a conventional method or a commercially available product can be used.

  As component (B), in particular, β-carotene, δ-tocopherol, ascorbic acid and its derivatives, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, α-lipoic acid, allantoin, stearyl glycyrrhetinate, Preference is given to dipotassium glycyrrhizinate, tranexamic acid and its derivatives, chamomile extract, tea extract and asunalo extract.

One or more components (B) can be used, and an antioxidant and an anti-inflammatory substance can be used in combination. The component (B) is preferably contained in the total composition in an amount of 0.00001 to 30% by mass, particularly 0.00001 to 5% by mass.
Moreover, when using a plant extract, it is preferable from points, such as a color and an odor, that 0.00001-5 mass%, especially 0.00001 1-3 mass% are contained as solid content in the whole composition.

  The cosmetic of the present invention contains, in addition to the above-mentioned components, general cosmetic ingredients such as oily ingredients, other ingredients and water, so that lotion, milky lotion, cream, cosmetic liquid, aqueous gel, pack It can be used as cosmetics. The dosage forms include emulsions, solubilized products, dispersions, gels and the like.

  Examples of oil components include hydrocarbon oils such as liquid paraffin and squalane; higher alcohols such as cetanol and stearyl alcohol; fatty acids such as palmitic acid and stearic acid; ester oils such as olive oil, jojoba oil, and neopentyl glycol dicaprate. Silicone oil such as methylpolysiloxane can be used, and the total composition can contain 0.001 to 50% by mass.

  Examples of the other components include water-soluble components such as water-soluble thickeners, water-soluble polyhydric alcohols, lower alcohols, pH adjusters, and surfactants.

Examples of the water-soluble thickener include carboxyvinyl polymer, xanthan gum, carrageenan, polyvinyl alcohol, polyacrylic acid, carboxymethylcellulose, gelatin, hyaluronic acid, tuberose polysaccharide, hydroxyethylcellulose and derivatives thereof. 001-3 mass% can be contained.
Examples of water-soluble polyhydric alcohols include glycerin, 1,3-butylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, and the like, and can be contained in an amount of 0.001 to 30% by mass in the entire composition.

Examples of the lower alcohols include ethanol and the like, and 0.001 to 60% by mass can be contained in the entire composition.
Examples of the pH adjuster include succinic acid, lactic acid, potassium hydroxide, sodium hydroxide and the like, and can be contained in an amount of 0.0001 to 2% by mass in the entire composition.
Moreover, 0.1-95 mass% of water can be contained in the whole composition.

  Furthermore, surfactants such as polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether can be contained in the total composition in an amount of 0.001 to 10% by mass.

  Moreover, it can also be set as dosage forms, such as a pop cosmetic, In that case, 1-30 mass% of bridge | crosslinking type polymers, such as polyacrylic acid and sodium polyacrylate, and salts, such as aluminum hydroxide, are 0.00. 0001 to 5 mass%, 0.001 to 60 mass% of a water-soluble polyhydric alcohol, 0.001 to 30 mass% of an oily base material, and 0.001 to 10 mass% of a surfactant can be contained.

  In addition to these, for example, moisturizers such as betaine, preservatives such as parabens, UV absorbers, dyes, fragrances, film-forming polymer compounds, powders and other feel-improving agents, chelating agents, extracts and vitamins And other physiologically active substances, medicinal agents and the like.

  The cosmetic of the present invention can be produced by a usual method, and is not limited to general skin cosmetics, but also includes medicinal cosmetics.

Production Example 1
The shrimp was chopped, and 1000 L of 20 volume% ethanol was added to 100 kg of the shredded, stirred and immersed at room temperature for 6 hours. This was filtered to obtain a ginger extract. The ginger extract was concentrated under reduced pressure to obtain 50.5 kg of a suspension. This suspension was filtered through celite to obtain 50.0 kg of a concentrate. Using 50 L of Diaion HP-20 manufactured by Mitsubishi Chemical Corporation, this concentrate was subjected to a water fraction (250 L), a 10% EtOH fraction (250 L), a 40% EtOH fraction (250 L), and an EtOH fraction (250 L). It was fractionated. The 10% EtOH fraction and the 40% EtOH fraction were respectively concentrated to obtain 562 g (A1) and 444 g (B1), respectively. Each was suspended in 25 L of ethanol and then filtered to obtain an ethanol-soluble material. This ethanol-soluble material was concentrated under reduced pressure to obtain 330 g (A2) and 315 g (B2), respectively. (B2) Divided into 3 portions, 105 g of silica gel 2.5 kg: eluent (ethyl acetate: methanol: water: acetic acid = 9: 1: 0: 0 → 3.5: 1: 0: 0 → 14: 4: 1 : 0.1 (B3) → 9: 5: 1.2: 0.12). (B3) was concentrated to obtain 75.1 g (B4). (B4) 2.5 kg ODS-A (60S-150) manufactured by YMC, eluent (0.1% TFA (trifluoroacetic acid) / 5% acetonitrile / H ₂ O → 0.1% TFA / 10% acetonitrile / H ₂ O → 0.1% TFA / 15% acetonitrile / H ₂ O → 0.1% TFA / 20% acetonitrile / H ₂ O). The fraction eluted with 0.1% TFA / 10% acetonitrile / H ₂ O was concentrated to obtain 22 g (B5). The fraction eluted with 0.1% TFA / 15% acetonitrile / H ₂ O was concentrated to obtain 35 g (C5). (B5) was purified with Sephadex LH-20 (Eluent 10% MeOH / H ₂ O) manufactured by Amersham Pharmacia and concentrated to obtain 2.5 g (B6). (B6) was purified with Sephadex LH-20 (eluent MeOH) manufactured by Amersham Pharmacia and concentrated to obtain 2.5 g (B6). (B6) is an ultrapack water based ODS (300/50 mm ID 40 mm) eluent 0.1% TFA / 8% CH ₃ CN / H ₂ O → 0.1% TFA / 20% CH ₃ CN / Fractionation with H ₂ O gave 11 mg (B7). (B7) was manufactured by YMC YMC-Pack Hydrosphere C18 SH-343250 / 20 mmD. Purification with 5 mm eluent 0.1% TFA / 8% acetonitrile / H ₂ O gave 6 mg of compound B (Fru-Ile-Tyr-OH). (C) was purified in the same manner as (B5) → (B6) → (B7) → B to obtain 5 mg of compound C (Fru-Val-Phe-OH). (A2) was purified in the same manner as B and C. Compound A (Fru-Val-Tyr-OH) 30 mg, Compound D (Fru-Val-Tyr-OCH ₃ ) 13 mg, Compound E (Fru-Ile-Val-OH) ) 4 mg and compound F (Fru-Val-Ile-OH) 5 mg were obtained.

Production Example 2
(1) Synthesis of Compound A:
L-valyl-L-tyrosine (manufactured by Kokusan Chemical) 1.01 g (3.6 mmol), glucose 9.08 g (50 mmol), sodium hydrogen carbonate 60 mg (0.7 mmol), and methanol 350 mL were placed in a 1 L eggplant flask for 2 hours. Heated to reflux. After the solvent was distilled off, azeotropic dehydration was performed with 100 mL of ethanol. To the dried solid, 350 mL of methanol was added and dissolved, and the mixture was further refluxed with heating for 2 hours. After distilling off the solvent, it was dissolved in 1000 mL of water. This solution was fractionated into a water fraction (5000 mL) and a 20% ethanol fraction (1000 mL) using 500 mL of Diaion HP-20 manufactured by Mitsubishi Chemical Corporation. The 20% ethanol fraction was concentrated to obtain Compound A (0.72 g).

(2) Synthesis of Compound B:
The compound A (L-valyl-L-tyrosine) was replaced with L-isoleucyl-L-tyrosine (manufactured by Kokusan Kagaku) and synthesized in the same manner to obtain compound B (0.36 g).

(3) Synthesis of Compound C:
The compound A (L-valyl-L-tyrosine) was replaced with L-valyl-L-phenylalanine (manufactured by Kokusan Kagaku) and synthesized in the same manner to obtain compound C (0.62 g).

(4) Synthesis of Compound E:
The compound A (L-valyl-L-tyrosine) was replaced with L-isoleucyl-L-valyl (manufactured by Kokusan Kagaku) and synthesized in the same manner to obtain compound E (1.10 g).

(5) Synthesis of compound F:
The compound A (L-valyl-L-tyrosine) was replaced with L-valyl-L-isoleucil (manufactured by Kokusan Kagaku) and synthesized in the same manner to obtain compound F (0.25 g).

(6) Synthesis of compound D:
20 mg of compound A was dissolved in 2 mL of methanol, 0.3 mL of trimethylsilyldiazomethane (manufactured by Tokyo Chemical Industry Co., Ltd.) was added, and the mixture was stirred at room temperature. After distilling off the solvent, YMC-Pack Hydrosphere C18 SH-343 250/20 mmI. D. Purification with 5 mm eluent 0.1% TFA / 8% acetonitrile / H ₂ O gave Compound D (13 mg).

Example 1
Gels having the compositions shown in Table 1 were produced and evaluated for wrinkle improvement effect, odor and color change. The results are also shown in Table 1.

(Manufacturing method)
Components (1) to (8) and (10) are added to component (11) and dissolved. To this, component (9) was added and neutralized, and then stirred to obtain a gel.

(Evaluation methods)
(1) Wrinkle improvement effect:
Paneled 60 healthy women aged 35 to 55 years, divided into 4 groups (15 each), and each person displayed the gel of the example or comparative example in the lower right eyelid region and the left lower eyelid region. One placebo product was applied at 0.1 mL each, twice a day for 10 weeks. The condition before the start of the test and after the application for 10 weeks was visually evaluated (score) based on the following criteria (J. Cosmet. Sci., 2000; 51: 127-139). The score before the test—the score after 10 weeks) was taken as the “wrinkle improvement effect value”, and the average value was determined (the “wrinkle improvement effect value of placebo” is the average value of 60 people in 4 groups).

(Evaluation criteria)
0: No wrinkles.
1: Faint.
2: Somewhat.
3: Yes.
4: There are quite a few.

(2) Odor change:
Each gel is filled in a glass container (volume: 50 mL) by 25 g, sealed and stored at 5 ° C. and 50 ° C. After storage for 1 month, samples at each storage temperature were taken out, left in a 25 ° C. water bath for 1 hour, then the storage container was opened, and the odor was subjected to sensory evaluation after approximately 30 seconds. Judgment was made according to the following criteria with a 5 ° C. product as a standard.
○: No change.
Δ: Slight change.
X: Clearly changed (unusable).

(3) Color change:
Each gel is filled in a glass container (capacity: 50 mL) by 50 g, sealed and stored at 5 ° C. and 50 ° C. After storage for 1 month, samples at each storage temperature were taken out and left in a 25 ° C. water bath for 1 hour, and then the color change was visually evaluated. Judgment was made according to the following criteria with a 5 ° C. product as a standard.
○: No change.
Δ: Slight change.
X: Clearly changed (unusable).

Example 2 (gel)
A gel having the following composition was produced.
(component)
(1) Ascorbic acid 2-glucoside 2 (mass%)
(2) Compound A of Production Example 2 0.0005
(3) Asunaro extract (manufactured by Ichimaru Falcos, Asunaro Liquid; solid content 0.25%) 1
(4) Carboxyvinyl polymer 0.5
(5) Polyoxyethylene methyl glucoside 10
(6) 86% glycerin 10
(7) N-amidino-L-proline 3
(8) Appropriate amount of succinic acid
(9) Potassium hydroxide 0.15
(10) Perfume appropriate amount
(11) Balance of purified water

(Manufacturing method)
Components (1) to (8) are added to component (11) and dissolved. To this, component (9) is added and neutralized, and then component (10) is added and stirred to obtain a gel.

Example 3 (milky lotion)
An emulsion having the composition shown below was produced.
(component)
(1) Palmitic acid 0.5 (mass%)
(2) Olive oil 2
(3) Cetanol 1
(4) Jojoba oil 5
(5) Sodium monohexadecyl phosphate 2
(6) Sorbitan monostearate 0.5
(7) Stearyl glycyrrhetinate 1
(8) Compound B of Production Example 1 0.0008
(9) 86% glycerin 15
(10) Ethanol 5
(11) Xanthan gum 0.1
(12) Balance of purified water

(Manufacturing method)
Components (1) to (7) are kept at 80 ° C. and uniformly dissolved to obtain an oil phase. Components (8) to (12) are dissolved, an oil phase is added with stirring, the mixture is treated with a homomixer, and then rapidly cooled to obtain an emulsion.

Example 4 (skin lotion)
A lotion having the following composition was produced.
(component)
(1) α-Lipoic acid 1 (mass%)
(2) Compound C of Production Example 2 0.0006
(3) Polyoxyethylene monolaurate (20) sorbitan 1
(4) 1,3-butylene glycol 3
(5) Sorbitol (70%) 2
(6) Sodium hyaluronate 0.05
(7) Ethanol 10
(8) Balance of purified water

(Manufacturing method)
Ingredients (1) to (8) are uniformly dissolved to obtain a skin lotion.

Example 5 (cream)
A cream having the following composition was produced.
(component)
(1) Allantoin 0.1 (mass%)
(2) Compound D of Production Example 1 0.0005
(3) Stearic acid 7.5
(4) cetostearyl alcohol 1.5
(5) Liquid paraffin 10
(6) Glycerin triisooctanoate 12
(7) Lanolin 3
(8) Cetyl palmitate 4
(9) Polyethylene glycol monostearate (40) 2
(10) Glycerol monostearate (self-emulsifying type) 5
(11) 1- (2-hydroxyethylamino) -3-
Isostearyloxy-2-propanol 0.2
(12) L-glutamic acid 0.1
(13) Alkyl-modified carboxyvinyl polymer 0.2
(14) Balance of purified water

(Manufacturing method)
Components (3) to (11) are kept at 80 ° C. and uniformly dissolved to obtain an oil phase. Ingredients (1), (2), (12) and (13) are added to (14) and dissolved, and the oil phase is added with stirring, treated with a homomixer, and then rapidly cooled to obtain a cream.

Example 6 (pack)
A pack having the following composition was produced.
(component)
(1) β-carotene 0.01 (mass%)
(2) Compound E of Production Example 2 0.0003
(3) Polyvinyl alcohol (molecular weight 98000) 13
(4) Ethanol 20
(5) Polyoxyethylene monolaurate (20) sorbitan 1
(6) Propylene glycol 3
(7) Glycerin 1
(8) Balance of purified water

(Manufacturing method)
Add components (3) and (5) to (7) to component (8) and dissolve. Thereafter, components (1) to (2) and (4) are added with stirring to obtain a pack.

Example 7 (a poultice)
A cataplasm having the composition shown below was produced.
(component)
(1) Epigallocatechin gallate 0.001 (mass%)
(2) Compound F 3 of Production Example 1
(3) 10% polyacrylic acid aqueous solution 35
(4) Sodium polyacrylate 7
(5) Glycerin 20
(6) Polyoxyethylene monolaurate (20) sorbitan 0.5
(7) Calcium chloride 20% aqueous solution 1
(8) Potash alum 10% aqueous solution 4
(9) Aluminum hydroxide 0.2
(10) Kaolin 4
(11) Balance of purified water

(Manufacturing method)
Components (3) to (5) are dissolved in a part of component (11), and components (1) to (2) and (6) to (9) are separately dissolved in the remainder of component (11) Is added to form an aqueous phase, and the component (10) is added with stirring to obtain a gel. This gel is uniformly coated on the nonwoven fabric to obtain a poultice.

  The cosmetics obtained in Examples 2 to 7 are all excellent in wrinkle improvement effect.

Claims (8)

The following components (A) and (B):
(A) General formula (1):
Fru-A-B-R (1)
(In the formula, Fru represents a fructosyl residue, A and B represent amino acid residues, and R represents a hydroxyl group in the C-terminal carboxyl group of the amino acid residue or a methyl esterified group thereof)
Fructosyl dipeptide represented by or salt thereof 0.00001-5 mass%,
(B) Antioxidant and / or anti-inflammatory substance 0.00001-30 mass%
Containing cosmetics.   Antioxidant of component (B) is α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, lutein, zeaxanthin, isozeaxanthin, rhodoxanthine, crocetin, 1,4-diazadichlorooctane, 2 , 5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, tocotrienol, dibutylhydroxytoluene, butylhydroxy Anisole, ascorbic acid and its derivatives, tannic acid, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, isoflavone, rutin, α-lipoic acid, ubiquinone, azulene, β-glucan, caffeic acid, calcic acid Selected from succinic acid, ethyl vanillin, farnesol, folic acid, hesperidin, kinetin, kojic acid, linolenic acid, mannitol, phytic acid, pullulan, pycnogenol, pyridoxine hydrochloride, saponins, selenium, squalene, thiotaurine and thiazolidinecarboxylic acid The cosmetic according to claim 1.   The cosmetic according to claim 1, wherein the antioxidant substance of component (B) is a plant extract having an antioxidant action.   The cosmetic according to claim 3, wherein the antioxidant substance of component (B) is selected from extracts of licorice, tomato, yukinoshita, juyu, horsetail, melissa, olive and grape.   The anti-inflammatory substance of component (B) is selected from allantoin, lysozyme chloride, guaiazulene, γ-oryzanol, glycyrrhetinic acid, stearyl glycyrrhetinate, glycyrrhizic acid and salts thereof, tranexamic acid and derivatives thereof, and epsilon aminocaproic acid Item 5. The cosmetic according to any one of Items 1 to 4.   The anti-inflammatory substance of component (B) is chamomile, peonies, lysins, tea, toki, peach, amacha, asunaro, arnica, ginkgo, inchinkou, turmeric, lauren, hypericum, dutch mustard, kumazasa, gentian, kojisou, confrey, Salvia, hawthorn, salamander, perilla, cypress, Atlantic millet, Atlantic mint, Sorax, thyme, clove, pearl millet, parsley, hamamelis, loquat, butcher bloom, bodaiju, mannenrou, buttonpi, cornflower, lavender, Roman chamomile The cosmetic according to any one of claims 1 to 4, wherein the cosmetic is selected from extracts.   A fructosyl dipeptide or a salt thereof in which component (A) is a valine residue or isoleucine residue and B is a tyrosine residue, phenylalanine residue, valine residue or isoleucine residue in the general formula (1) The cosmetic according to any one of claims 1 to 6.   Cosmetics of any one of Claims 1-7 which contain 0.0003-0.01 mass% of component (A), and 0.00001-3 mass% of components (B).