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JP2006518999A - チオレドキシン発現の改変のためのオリゴマー化合物 - Google Patents

チオレドキシン発現の改変のためのオリゴマー化合物 Download PDF

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Publication number
JP2006518999A
JP2006518999A JP2006501523A JP2006501523A JP2006518999A JP 2006518999 A JP2006518999 A JP 2006518999A JP 2006501523 A JP2006501523 A JP 2006501523A JP 2006501523 A JP2006501523 A JP 2006501523A JP 2006518999 A JP2006518999 A JP 2006518999A
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Prior art keywords
cancer
compound
seq
compound according
lna
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JP2006501523A
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Japanese (ja)
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JP2006518999A5 (fr
Inventor
ボー・ハンセン
シャルロッテ・アルベク・トゥルーエ
カミーレ・ドゥモング・ペーターセン
マイケン・ヴェスターゴー
マルギット・ヴィッセンバッハ
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Roche Innovation Center Copenhagen AS
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Santaris Pharma AS
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Withdrawn legal-status Critical Current

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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/341Gapmers, i.e. of the type ===---===
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    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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JP2006501523A 2003-02-10 2004-02-10 チオレドキシン発現の改変のためのオリゴマー化合物 Withdrawn JP2006518999A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200300188 2003-02-10
PCT/DK2004/000095 WO2004069990A2 (fr) 2003-02-10 2004-02-10 Composes oligomeres pour la modulation de l'expression de thioredoxine

Publications (2)

Publication Number Publication Date
JP2006518999A true JP2006518999A (ja) 2006-08-24
JP2006518999A5 JP2006518999A5 (fr) 2007-03-22

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ID=32842639

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JP2006501523A Withdrawn JP2006518999A (ja) 2003-02-10 2004-02-10 チオレドキシン発現の改変のためのオリゴマー化合物

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EP (1) EP1592794A2 (fr)
JP (1) JP2006518999A (fr)
AU (1) AU2004209597A1 (fr)
CA (1) CA2515554A1 (fr)
WO (1) WO2004069990A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015093853A (ja) * 2013-11-12 2015-05-18 学校法人東京理科大学 ボラノホスフェート化合物、及び核酸オリゴマー
JP2016105703A (ja) * 2007-11-26 2016-06-16 エンゾン ファーマシューティカルズ,インコーポレーテッド アンドロゲン受容体を標的化するlnaアンタゴニスト

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU760396B2 (en) * 1998-01-30 2003-05-15 Lorus Therapeutics Inc. Oligonucleotide sequences complementary to thioredoxin or thioredoxin reductase genes and methods of using same to modulate cell growth
WO2001048190A2 (fr) * 1999-12-23 2001-07-05 Exiqon A/S Utilisations therapeutiques d'oligonucleotides a lna modifie

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016105703A (ja) * 2007-11-26 2016-06-16 エンゾン ファーマシューティカルズ,インコーポレーテッド アンドロゲン受容体を標的化するlnaアンタゴニスト
JP2015093853A (ja) * 2013-11-12 2015-05-18 学校法人東京理科大学 ボラノホスフェート化合物、及び核酸オリゴマー

Also Published As

Publication number Publication date
EP1592794A2 (fr) 2005-11-09
CA2515554A1 (fr) 2004-08-19
WO2004069990A3 (fr) 2004-09-16
WO2004069990A2 (fr) 2004-08-19
AU2004209597A1 (en) 2004-08-19

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