JP2006130055A - Cryotherapy apparatus using Peltier module / element and cryotherapy temperature control method using Peltier module / element - Google Patents
Cryotherapy apparatus using Peltier module / element and cryotherapy temperature control method using Peltier module / element Download PDFInfo
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Abstract
【課題】 本発明は、ペルチェモジュールを用いて患部を急速冷却および急速加熱の温度制御をすることによって各種皮膚腫瘍、色素性病変等の病変部を壊死させ切除する凍結治療装置およびその温度制御方法を提供する
【解決手段】 本発明によれば、製作の難しいペルチェ素子に比べて製作が容易で安価な市販のペルチェモジュールを使用するので製作が容易で冷却面積が比較的大きい凍結治療装置が達成され、有効に皮膚の凍結治療を行うことが出来るという効果が得られる。また、凍結患部を解凍したり、再凍結を繰り返したりすることにより、皮膚患部の細胞壊死率を向上させる治療を効果的に行うことが出来る。また、ヒートシンクを液体窒素で冷却することによって、ペルチェモジュールの冷却速度を向上させると共に、二重容器隙間部に充填させた二酸化炭素を昇華させ真空断熱効果を得ることが出来、断熱厚さを減少できる効果がある。
【選択図】 図１PROBLEM TO BE SOLVED: To provide a cryotherapy apparatus and a temperature control method for necrotizing and excising lesions such as various skin tumors and pigmented lesions by using a Peltier module to perform temperature control of rapid cooling and rapid heating of the affected area According to the present invention, a cryotherapy apparatus that is easy to manufacture and has a relatively large cooling area can be achieved by using a commercially available Peltier module that is easier to manufacture and cheaper than a Peltier element that is difficult to manufacture. Thus, the effect of freezing skin can be effectively obtained. Moreover, the treatment which improves the cell necrosis rate of a skin affected part can be performed effectively by thawing | defrosting a frozen affected part or repeating refreezing. In addition, by cooling the heat sink with liquid nitrogen, the cooling rate of the Peltier module can be improved, and the carbon dioxide filled in the double container gap can be sublimated to obtain a vacuum insulation effect, reducing the insulation thickness. There is an effect that can be done.
[Selection] Figure 1
Description
本発明は、ペルチェモジュールを用いて患部を急速冷却および急速加熱の温度制御をすることによって皮膚癌または疣、痣、シミ等の病変部を壊死させ切除する凍結治療装置およびその温度制御方法に関する。 The present invention relates to a cryotherapy apparatus and a temperature control method for necrotizing and excising skin cancer or lesions such as hemorrhoids, wrinkles, and stains by performing temperature control of rapid cooling and rapid heating of an affected area using a Peltier module.
冷凍療法は、皮膚の種々の良性、悪性腫瘍、色素性病変に対して皮膚科外来で日常的に行われている治療である。冷凍療法は、患者に与える苦痛が少ない、液体窒素があれば容易に行えるなどの利点があるが、その反面、現在行われている冷凍療法は、外科的切除、レーザー療法と異なり、凍結範囲を３次元的に制御することは不可能で、もっぱら術者の経験と感により調節されている。従って、しばしば、不必要に周囲の正常組織を冷凍し結果的に水疱を形成して患者に苦痛を与えたり、また、治療が不十分で目的とする腫瘍の治療が不十分であったりする。そのため、この治療範囲を制御できる凍結療法の有用性は極めて大きい。 Cryotherapy is a treatment routinely performed at a dermatological outpatient for various benign, malignant tumors, and pigmented lesions of the skin. Cryotherapy has the advantages of less pain to the patient and easy to do with liquid nitrogen, but on the other hand, cryotherapy currently performed differs from surgical excision and laser therapy in that it has a freezing range. It is impossible to control in three dimensions, and it is adjusted exclusively by the experience and feeling of the surgeon. Therefore, often the surrounding normal tissue is unnecessarily frozen, resulting in blistering and suffering to the patient, or the treatment of the target tumor is inadequate due to insufficient treatment. Therefore, the usefulness of cryotherapy that can control this therapeutic range is extremely great.
かかる問題を解決するために、ｐ型とｎ型の単体のペルチェ半導体と電極で構成されるペルチェ素子を用いた微小温度制御装置が開発され、皮膚科治療に用いられようとしている。例えば、特許文献１では、電極とヒートシンクを一体化することによりコンパクトな凍結治療装置が達成され、特許文献２では、ペルチェ素子を用いた凍結治療装置先端の形状を変えることによってより小さな領域の温度制御を可能としている。さらに、非特許文献１では、冷媒に固形二酸化炭素つまりドライアイスを用いて、ペルチェ素子を用いた凍結治療装置のヒートシンクを冷却している。 In order to solve such a problem, a micro temperature control device using a Peltier element composed of a single P-type and n-type Peltier semiconductor and an electrode has been developed and is being used for dermatological treatment. For example, in Patent Document 1, a compact cryotherapy apparatus is achieved by integrating an electrode and a heat sink, and in Patent Document 2, a temperature in a smaller region is achieved by changing the shape of the tip of the cryotherapy apparatus using a Peltier element. Control is possible. Further, in Non-Patent Document 1, the heat sink of a cryotherapy apparatus using a Peltier device is cooled by using solid carbon dioxide, that is, dry ice as a refrigerant.
かかる技術では、微小領域の冷却制御が可能となったが、温度制御部にペルチェ半導体を組み込んだペルチェ素子を使用しているために、装置の製作が難しく、製品の価格も高い欠点があった。また、冷媒にドライアイス等を用いる場合、皮膚科の医院でドライアイスを保存するための経費がかかる欠点があった。
これまでの凍結療法は、綿球にしみこませた液体窒素、液体窒素で冷やした金属、あるいは、液体窒素のスプレーなどの凍結範囲を制御できない治療方法であった。そのため、過度な冷凍、また、不十分な冷凍による治療がしばしばなされている。また、術者の毎の個人差、また、同一術者でも治療毎の凍結強度の変化が避けられない。ペルチェ素子を用いた凍結装置は、電流の強さ、冷却時間を制御することにより凍結範囲を制御することが可能であり、また、この２つのパラメーターを一定にすることにより術者間の差、治療毎の差も生じない治療が可能となる。また、ペルチェ素子を用いた凍結治療装置は微小領域の冷凍治療には適しているが、装置の構造と製作が困難で装置価格が高価になる問題があった。 Conventional cryotherapy has been a treatment method in which the freezing range such as liquid nitrogen soaked in a cotton ball, metal cooled with liquid nitrogen, or spray of liquid nitrogen cannot be controlled. Therefore, treatment by excessive freezing or insufficient freezing is often performed. In addition, individual differences for each operator, and changes in the freezing strength for each treatment are unavoidable even for the same operator. The freezing device using the Peltier device can control the freezing range by controlling the current intensity and the cooling time, and by making these two parameters constant, Treatment that does not cause a difference between treatments is possible. Although a cryotherapy apparatus using a Peltier element is suitable for cryotherapy of a micro area, there is a problem that the structure and manufacture of the apparatus are difficult and the apparatus price is expensive.
一方、皮膚科治療においては、直径５ｍｍ程度の領域以上の冷凍治療を行う必要があり、必ずしも、極微細領域の冷凍治療が必要でない。 On the other hand, in dermatological treatment, it is necessary to perform cryotherapy over an area having a diameter of about 5 mm, and it is not always necessary to perform cryotherapy in an extremely fine area.
本発明は、従来のペルチェ素子を用いる凍結治療装置を簡便化し、市販のペルチェモジュールを使用した実用性の高い皮膚治療を目的とする凍結治療装置およびその温度制御方法を提供することを目的としている。 An object of the present invention is to simplify a cryotherapy apparatus using a conventional Peltier element, and to provide a cryotherapy apparatus aiming at highly practical skin treatment using a commercially available Peltier module and a temperature control method thereof. .
本発明によれば、少なくとも２つの面である第１１面と第１２面を持ち前記第１１面が凍結治療対象物に接触する先端チップと、少なくとも２つの面である第２１面と第２２面を持つペルチェモジュールと、前記ペルチェモジュールを低温に保つヒートシンクと、前記ペルチェモジュールの通電電流を逆転制御するパワーモジュールと、前記ペルチェモジュールの温度を制御する温度制御コンピュータ、とで構成され、前記第１２面と前記第２１面が接触し、前記第２２面と前記ヒートシンクとが接触するよう配置されることを特徴とする凍結治療装置が得られる。 According to the present invention, the tip has at least two surfaces, the eleventh surface and the twelfth surface, and the eleventh surface contacts the cryotherapy object, and the at least two surfaces, the twenty-first surface and the twenty-second surface. The Peltier module, a heat sink that keeps the Peltier module at a low temperature, a power module that reversely controls the energization current of the Peltier module, and a temperature control computer that controls the temperature of the Peltier module. A cryotherapy apparatus is obtained in which the surface and the twenty-first surface are in contact with each other, and the twenty-second surface and the heat sink are in contact with each other.
本発明によれば、前記温度制御コンピュータが前記パワーモジュールの通電電流逆転制御を複数回可逆的に制御できるよう構成したことを特徴とする凍結治療装置が得られる。 According to the present invention, it is possible to obtain a cryotherapy apparatus configured such that the temperature control computer can reversibly control energization current reversal control of the power module a plurality of times.
本発明によれば、少なくとも２つの面である第３１１面と第３１２面を持ち前記第３１１面が凍結治療対象物に接触する先端チップと、少なくとも２つの面である第３２１面と第３２２面を持つペルチェ素子と、前記ペルチェモジュールを低温に保つヒートシンク、と前記ペルチェ素子の通電電流を逆転制御するパワーモジュールと、前記ペルチェ素子の温度を制御する温度制御コンピュータ、とで構成され、前記第３１２面と前記第３２１面が接触し、前記第３２２面と前記ヒートシンクとが接触するよう配置されることを特徴とする凍結治療装置が得られる。 According to the present invention, there are at least two surfaces, a 311 surface and a 312 surface, the tip tip contacting the cryotherapy object, and the at least two surfaces, a 321 surface and a 322 surface. The Peltier element, a heat sink that keeps the Peltier module at a low temperature, a power module that reversely controls the energization current of the Peltier element, and a temperature control computer that controls the temperature of the Peltier element. A cryotherapy apparatus is provided in which a surface and the 321st surface are in contact with each other, and the 322th surface and the heat sink are in contact with each other.
本発明によれば、前記温度制御コンピュータが前記パワーモジュールの通電電流逆転制御を複数回可逆的に制御できるよう構成したことを特徴とする請求項３記載の凍結治療装置が得られる。 According to the present invention, the cryotherapy apparatus according to claim 3 is configured such that the temperature control computer can reversibly control the energization current reversal control of the power module a plurality of times.
本発明によれば、前記ヒートシンクの冷却を液体窒素で行う事を特徴とする請求項１乃至４の内一に記載の凍結治療装置が得られる。 According to the present invention, the cryotherapy apparatus according to any one of claims 1 to 4 is obtained, wherein the heat sink is cooled with liquid nitrogen.
本発明によれば、前記焼却装置全体を、密封容器による２重容器構造とし、２重容器隙間部に乾燥二酸化炭素を充填したことを特徴とする凍結治療装置が得られる。 According to the present invention, there is obtained a cryotherapy apparatus characterized in that the entire incinerator has a double-container structure with a sealed container, and the double container gap is filled with dry carbon dioxide.
本発明によれば、前記ペルチェモジュールによる凍結治療装置において、前記ペルチェモジュールを加熱状態に制御し、前記２１面および前記１２面を通して前記第１１面を常温に保つ第１ステップと、前記ペルチェモジュールの通電電流の流れを前記第１ステップと逆転させる第２ステップと、前記ヒートシンクの熱を前記第２２面と前記第２１面ならびに前記第１２面を介し前記第１１面に伝え、前期凍結治療対象物を急速冷却することを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in the cryotherapy apparatus using the Peltier module, the first step of controlling the Peltier module to a heated state and maintaining the eleventh surface at room temperature through the 21st surface and the 12th surface; A second step of reversing the flow of the energization current with the first step, and heat of the heat sink is transmitted to the eleventh surface via the twenty-second surface, the twenty-first surface and the twelfth surface, and a cryopreservation treatment object A cryotherapy temperature control method characterized by rapidly cooling the water is obtained.
本発明によれば、前記凍結治療対象物が人体の疾患であり、前記急速冷却は、人体の疾患の凍結であることを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, there is obtained a cryotherapy temperature control method, wherein the cryotherapy object is a human disease, and the rapid cooling is freezing of a human disease.
本発明によれば、前記ペルチェモジュールによる凍結治療装置において、第１１面を常温あるいは体温に保つ第１の状態と、次にヒートシンクの熱を第１１面に伝え第１１面をほぼヒートシンクの温度状態にする第２の状態、とを複数回繰り返すことを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in the cryotherapy apparatus using the Peltier module, the first state in which the eleventh surface is kept at room temperature or body temperature, and then the heat of the heat sink is transmitted to the eleventh surface, and the eleventh surface is substantially in the temperature state of the heat sink. Thus, a cryotherapy temperature control method characterized in that the second state is repeated a plurality of times.
本発明によれば、前記ペルチェモジュールによる凍結治療装置において前記人体の疾患が凍結した後で、前記第１１面の冷却時間と温度とを調節し、人体の凍結領域の大きさと深さを制御する事を特徴とする凍結治療温度制御方法が得られる。 According to the present invention, after the human disease is frozen in the cryotherapy apparatus using the Peltier module, the cooling time and temperature of the eleventh surface are adjusted to control the size and depth of the frozen region of the human body. A cryotherapy temperature control method characterized by this is obtained.
本発明によれば、前記第１１面を前記人体の疾患患部に接触させた状態で、前記第１の状態と前記第２の状態を複数回繰り返し患部細胞の壊死率を向上させることを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, the eleventh surface is brought into contact with the diseased affected part of the human body, and the first state and the second state are repeated a plurality of times to improve the necrosis rate of the affected part cell. A cryotherapy temperature control method is obtained.
本発明によれば、前記ペルチェ素子による凍結治療装置において、前記ペルチェ素子を加熱状態に制御し、前記３２２面および前記３１２面を通して前記第３１１面を常温に保つ第３１ステップと、前記ペルチェ素子の通電電流の流れを前記第３１ステップと逆転させる第３２ステップと、前記ヒートシンクの熱を前記第３２２面と前記第３２１面ならびに前記第３１２面を介し前記第３１１面に伝え、前期凍結治療対象物を急速冷却することを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in the cryotherapy apparatus using the Peltier element, the 31st step of controlling the Peltier element to a heated state and maintaining the 311 surface at room temperature through the 322 surface and the 312 surface, The 32nd step of reversing the flow of the energization current from the 31st step, and the heat of the heat sink is transmitted to the 311 surface via the 322 surface, the 321 surface and the 312 surface, and the first cryotherapy treatment object A cryotherapy temperature control method characterized by rapidly cooling the water is obtained.
本発明によれば、前記凍結治療対象物が人体の疾患であり、前記急速冷却は、人体の疾患の凍結であることを特徴とする請求項１２記載の凍結治療温度制御方法が得られる。
本発明によれば、前記ペルチェ素子による凍結治療装置において、第３１１面を常温あるいは体温に保つ第３１の状態と、次にヒートシンクの熱を第３１１面に伝える第３１１面をほぼヒートシンクの温度状態にする第３２の状態とを複数回繰り返すことを特徴とする凍結治療温度制御方法が得られる。
According to the present invention, the cryotherapy temperature control method according to claim 12, wherein the cryotherapy object is a human disease, and the rapid cooling is freezing of a human disease.
According to the present invention, in the cryotherapy apparatus using the Peltier device, the 31st state for keeping the 311 surface at room temperature or body temperature, and the 311 surface for transferring the heat of the heat sink to the 311 surface are substantially the temperature state of the heat sink. Thus, the cryotherapy temperature control method can be obtained in which the thirty-second state is repeated a plurality of times.
本発明によれば、前記ペルチェ素子による凍結治療装置において、前記人体の疾患が凍結した後で、前記第３１１面の冷却時間と温度とを調節し、人体の凍結領域の大きさと深さを制御する事を特徴とする凍結治療温度制御方法が得られる。
本発明によれば、前記第３１１面を前記人体の疾患患部に接触させた状態で、前記第３１の状態と前記第３２の状態を複数回繰り返し患部細胞の壊死率を向上させることを特徴とする凍結治療温度制御方法が得られる。
According to the present invention, in the cryotherapy apparatus using the Peltier element, after the human disease is frozen, the cooling time and temperature of the third surface are adjusted to control the size and depth of the frozen region of the human body. Thus, a cryotherapy temperature control method can be obtained.
According to the present invention, the 31st surface and the 32nd state are repeated a plurality of times in a state where the 311 surface is in contact with the diseased affected part of the human body, and the necrosis rate of the affected cell is improved. A cryotherapy temperature control method is obtained.
本発明によれば、前記第１１面あるいは第３１１面の近傍に温度センサーを設定し、当該面の温度をモニターしながら、前記温度制御コンピュータで前記パワーモジュールの制御を行う事を特徴とする凍結治療温度制御方法が得られる。 According to the present invention, the temperature module is set near the eleventh surface or the third surface, and the power module is controlled by the temperature control computer while monitoring the temperature of the surface. A therapeutic temperature control method is obtained.
本発明によれば、製作の難しいペルチェ素子に比べて製作が容易で安価な市販のペルチェモジュールを使用するので製作が容易で冷却面積が比較的大きい凍結治療装置が達成され、有効に皮膚の凍結治療を行うことが出来るという効果が得られる。また、凍結患部を解凍したり、再凍結を繰り返したりすることにより、標的病変における細胞壊死率を向上させることが可能となる。 According to the present invention, since a commercially available Peltier module that is easier to manufacture and cheaper than a Peltier element that is difficult to manufacture is used, a cryotherapy device that is easy to manufacture and has a relatively large cooling area is achieved, and effective skin freezing is achieved. An effect that treatment can be performed is obtained. Moreover, it becomes possible to improve the cell necrosis rate in the target lesion by thawing the frozen affected part or repeating refreezing.
また、ヒートシンクを液体窒素で冷却することによって、ペルチェモジュールの冷却速度を向上させるとともに、二重容器隙間部に充填させた二酸化炭素を昇華させ真空断熱効果を得ることが出来、断熱厚さを減少できる効果がある。 In addition, by cooling the heat sink with liquid nitrogen, the cooling rate of the Peltier module can be improved and the carbon dioxide filled in the gap between the double containers can be sublimated to obtain a vacuum insulation effect, reducing the insulation thickness. There is an effect that can be done.
以下、本発明の実施の形態について図面を参照しながら説明する。
図１は本発明の実施の形態による、通常断熱材を用いた凍結治療装置の概略構成を示す図である。図１を参照すると、ペルチェモジュール１が熱伝導生の良いアルミニウムや銅などで製作される先端チップ２と熱伝導の良い金属で製作されたヒートシンク５に挟まれている。ヒートシンク５は、液体窒素９を収納する内筒６にハンダ等で接着されている。ペルチェモジュール１と先端チップ２やヒートシンク５はシリコーンゴム接着剤や熱伝導性グリースなどで接着され、熱応力がかからない構造となっている。
Hereinafter, embodiments of the present invention will be described with reference to the drawings.
FIG. 1 is a diagram showing a schematic configuration of a cryotherapy apparatus using a normal heat insulating material according to an embodiment of the present invention. Referring to FIG. 1, a Peltier module 1 is sandwiched between a tip chip 2 made of aluminum, copper or the like having good heat conduction and a heat sink 5 made of metal having good heat conduction. The heat sink 5 is bonded to the inner cylinder 6 containing the liquid nitrogen 9 with solder or the like. The Peltier module 1, the tip chip 2, and the heat sink 5 are bonded with a silicone rubber adhesive, heat conductive grease, or the like, and have a structure in which no thermal stress is applied.
ペルチェモジュール１は一辺が６ｍｍから５０ｍｍの正方形または長方形であり、先端チップ２の皮膚と接触する被温度制御面３は直径３ｍｍから５０ｍｍである。前記先端チップ２は少なくとも２面（第１１面および第１２面、不図示）を持ち、前記被温度制御面３は第１１面に相当し、凍結治療対象物と接触する。またペルチェモジュール１も少なくとも２面（第２１面および第２２面、不図示）を持ち、前記第１２面と前記第２１面が接触する。そして、前記２２面と前記ヒートシンク５とが接触する構造となっている。 The Peltier module 1 is a square or rectangle having a side of 6 mm to 50 mm, and the temperature-controlled surface 3 that contacts the skin of the tip 2 has a diameter of 3 mm to 50 mm. The tip 2 has at least two surfaces (an eleventh surface and a twelfth surface, not shown), and the temperature-controlled surface 3 corresponds to an eleventh surface and is in contact with a cryotherapy object. The Peltier module 1 also has at least two surfaces (a 21st surface and a 22nd surface, not shown), and the 12th surface and the 21st surface are in contact with each other. The 22 surfaces and the heat sink 5 are in contact with each other.
これらの装置は金属またはプラスチック製の外筒７に覆われており、内筒６と外筒７の間を発泡ポリウレタンや発泡ポリスチレン等の断熱材１０が充填されている。その断熱層厚さは、大略１０ｍｍから３０ｍｍ程度である。 These apparatuses are covered with an outer cylinder 7 made of metal or plastic, and a space between the inner cylinder 6 and the outer cylinder 7 is filled with a heat insulating material 10 such as polyurethane foam or polystyrene foam. The thickness of the heat insulating layer is about 10 mm to 30 mm.
先端チップ２の被温度制御面３近傍に温度センサー４が装着され、温度制御コンピュータ１２ならびにパワーモジュール１３を介してペルチェモジュール１の温度制御を行う。 A temperature sensor 4 is mounted in the vicinity of the temperature control surface 3 of the tip 2 and performs temperature control of the Peltier module 1 via the temperature control computer 12 and the power module 13.
まず内筒６に液体窒素を入れてヒートシンク５を冷却するとき、ペルチェモジュール１は加熱モードで作動し、先端チップ２の温度を大略体温程度に保っている。凍結治療装置を皮膚腫瘍、色素性病変の患部に接触させてからペルチェモジュール１の電流を逆転させ急速冷却を行う。その時、温度センサー４の温度をモニターすることによって、皮膚組織の過冷却解除を関知し患部の組織の凍結開始をモニターし、冷却時間とペルチェモジュール１の通電電流を制御することにより、患部の凍結深さを制御し、皮下組織などの健康部位の凍結を防止する。 First, when liquid nitrogen is put into the inner cylinder 6 to cool the heat sink 5, the Peltier module 1 operates in a heating mode, and the temperature of the tip 2 is kept at about body temperature. After the cryotherapy apparatus is brought into contact with the affected area of the skin tumor or pigmented lesion, the current of the Peltier module 1 is reversed to perform rapid cooling. At that time, the temperature of the temperature sensor 4 is monitored to detect the release of supercooling of the skin tissue to monitor the start of freezing of the affected tissue, and by controlling the cooling time and the energization current of the Peltier module 1, Control depth and prevent freezing of healthy sites such as subcutaneous tissue.
さらに、ペルチェモジュール１の電流を逆転することにより、凍結患部を解凍し、患部の細胞壊死率を高めることも可能である。この制御を与えられたシークエンスに従って自動的に制御することも可能である。温度制御コンピュータ１２とパワーモジュール１３は一体化して装置に組み込むことも可能である。 Further, by reversing the current of the Peltier module 1, it is possible to thaw the frozen affected area and increase the cell necrosis rate of the affected area. It is also possible to automatically control this control according to a given sequence. The temperature control computer 12 and the power module 13 can be integrated into the apparatus.
また、本発明による温度制御法は、ペルチェモジュールを用いる本凍結治療装置に限定されるものではなく、ペルチェ素子を用いた温度制御法にも適用できる。本発明によるペルチェ素子を用いた凍結治療装置は図１あるいは図２においてペルチェモジュール４をペルチェ素子に置き代えたもので特に図示しない。ペルチェ素子を用いた凍結治療装置においても前記先端チップ２は少なくとも２面（第３１１面および第３１２面、不図示）を持ち、前記被温度制御面３は第３１１面に相当し、凍結治療対象物と接触する。またペルチェ素子１も少なくとも２面（第３２１面および第３２２面、不図示）を持ち、前記第３１２面と前記第３２１面が接触する。そして、前記３２２面と前記ヒートシンク５とが接触する構造となっている。 Further, the temperature control method according to the present invention is not limited to the present cryotherapy apparatus using the Peltier module, and can also be applied to a temperature control method using a Peltier element. The cryotherapy apparatus using the Peltier element according to the present invention is not particularly shown in FIG. 1 or FIG. 2 except that the Peltier module 4 is replaced with a Peltier element. Also in a cryotherapy apparatus using a Peltier element, the tip 2 has at least two surfaces (a 311th surface and a 312th surface, not shown), the temperature-controlled surface 3 corresponds to a 311 surface, and is a cryotherapy object. Contact with objects. The Peltier element 1 also has at least two surfaces (a 321st surface and a 322th surface, not shown), and the 312th surface and the 321st surface are in contact with each other. And it has the structure where the said 322 surface and the said heat sink 5 contact.
図２は、本発明の実施の形態による、二酸化炭素充填層を用いた凍結治療装置の概略構成を示す図である。図２を参照すると、内筒１７はベローズやフレキブルチューブで製作され、ヒートシンク５とハンダ等で接合されている。装置１，２，５，１７は気密性のある外筒１８に収納され、その隙間に大略大気圧程度の二酸化炭素ガスが充填されている。内筒１７と外筒１８はＯリング２０を介して接合され、内筒と外筒の隙間の気密を保っている。温度センサー４やペルチェモジュール１の導線は気密コネクタ２１を介して接続されている。本発明の形態によると、フレキシブルチューブの弾性で、ペルチェモジュール１と先端チップ２を圧着しているため、液体窒素を入れたときに容器が温度収縮してもペルチェモジュール１に適当な圧着力が作用する利点がある。 FIG. 2 is a diagram showing a schematic configuration of a cryotherapy apparatus using a carbon dioxide filled layer according to an embodiment of the present invention. Referring to FIG. 2, the inner cylinder 17 is made of a bellows or a flexible tube, and is joined to the heat sink 5 with solder or the like. The devices 1, 2, 5, and 17 are housed in an airtight outer cylinder 18, and the gap is filled with carbon dioxide gas at about atmospheric pressure. The inner cylinder 17 and the outer cylinder 18 are joined via an O-ring 20 to keep the gap between the inner cylinder and the outer cylinder airtight. Conductive wires of the temperature sensor 4 and the Peltier module 1 are connected via an airtight connector 21. According to the embodiment of the present invention, the Peltier module 1 and the tip chip 2 are pressure-bonded by the elasticity of the flexible tube. There are advantages to work.
本装置が作動していないとき、二酸化炭素は単なるガス層として熱を伝えるが、装置動作時に液体窒素９を内筒１７に充填すると内筒１７が極低温になり二酸化炭素１９がドライアイスとして内筒１７外壁に昇華付着する。この作用によって、隙間が真空状態となり、高性能断熱が達成される。 When the apparatus is not in operation, carbon dioxide transfers heat as a mere gas layer, but when the apparatus is in operation, filling the inner cylinder 17 with liquid nitrogen 9 causes the inner cylinder 17 to be at a very low temperature, so that the carbon dioxide 19 is contained as dry ice. Sublimation adheres to the outer wall of the cylinder 17. By this action, the gap is in a vacuum state, and high performance heat insulation is achieved.
本発明の作用によって、薄い断熱層厚さで液体窒素の断熱が可能となるので、装置がコンパクトになり医師の治療がしやすくなる。従来の真空断熱を使った極低温プローブは、高度な真空容器にしたり、常に真空ポンプで吸引したりして使用していた。本発明の断熱層によれば、装置を使用しないときは、この隙間は大気圧となっているので、高度な真空容器が必要とならない。この、真空断熱機構は、液体窒素等の極低温冷媒を使用する全ての真空断熱層に適用されるもので、本凍結治療装置に限定されるものではない。 The action of the present invention makes it possible to insulate liquid nitrogen with a thin insulating layer thickness, so that the apparatus is compact and easy for a doctor to treat. Conventional cryogenic probes using vacuum insulation have been used in advanced vacuum vessels or always with a vacuum pump. According to the heat-insulating layer of the present invention, when the apparatus is not used, this gap is at atmospheric pressure, so that an advanced vacuum vessel is not necessary. This vacuum heat insulation mechanism is applied to all vacuum heat insulation layers using a cryogenic refrigerant such as liquid nitrogen, and is not limited to the present cryotherapy apparatus.
本発明に係るペルチェモジュールによる凍結治療装置および温度制御方法は、各種皮膚腫瘍、色素性病変等冷凍凍結削除や、その他の人体部位の部分凍結や加熱を行う医療の様々な分野に広く適用できる。 The cryotherapy apparatus and the temperature control method using the Peltier module according to the present invention can be widely applied to various fields of medical treatment in which various types of skin tumors, pigmented lesions and the like are frozen and deleted, and other parts of the human body are partially frozen and heated.
特に、皮膚の疾患部位を、健常部位を切除することなく正確に取り除くことが出来る。また、冷凍治療は治癒後の組織快復が良好なので医療および美容外科等に広く用いることが出来る。 In particular, the diseased part of the skin can be accurately removed without excising the healthy part. In addition, the freezing treatment can be widely used for medical treatment and cosmetic surgery because the tissue recovery after healing is good.
１ ペルチェモジュール
２ 先端チップ
３ 被温度制御面
４ 温度センサー
５ ヒートシンク
６ 内筒
７ 外筒
８ スペーサー
９ 液体窒素
１０ 断熱材
１１ ふた
１２ 温度制御コンピュータ
１３ パワーモジュール
１４ 表皮
１５ 真皮
１６ 皮下組織
１７ フレキシブルチューブ製内筒
１８ 気密外筒
２０ Ｏリング
２１ 気密コネクタ
1 Peltier module 2 Tip tip 3 Temperature control surface
4 temperature sensor 5 heat sink 6 inner cylinder 7 outer cylinder 8 spacer 9 liquid nitrogen 10 heat insulating material 11 lid 12 temperature control computer 13 power module 14 epidermis 15 dermis 16 subcutaneous tissue 17 flexible tube inner cylinder 18 airtight outer cylinder 20 O-ring 21 airtight connector
Claims (17)
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| JP2004322309A JP4324673B2 (en) | 2004-11-05 | 2004-11-05 | Cryotherapy device with Peltier module |
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| JP2004322309A JP4324673B2 (en) | 2004-11-05 | 2004-11-05 | Cryotherapy device with Peltier module |
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|---|---|---|---|---|
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| US9155584B2 (en) | 2012-01-13 | 2015-10-13 | Myoscience, Inc. | Cryogenic probe filtration system |
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| US9241753B2 (en) | 2012-01-13 | 2016-01-26 | Myoscience, Inc. | Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments |
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| US9408745B2 (en) | 2007-08-21 | 2016-08-09 | Zeltiq Aesthetics, Inc. | Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue |
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| JP2017051645A (en) * | 2011-11-16 | 2017-03-16 | ザ ジェネラル ホスピタル コーポレイション | Method and apparatus for cryogenic treatment of skin tissue |
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| US9668800B2 (en) | 2013-03-15 | 2017-06-06 | Myoscience, Inc. | Methods and systems for treatment of spasticity |
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| CN107440783A (en) * | 2017-09-19 | 2017-12-08 | 杜忠海 | A kind of new insertion type probe for cold therapy of liver cancer |
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| US9861520B2 (en) | 2009-04-30 | 2018-01-09 | Zeltiq Aesthetics, Inc. | Device, system and method of removing heat from subcutaneous lipid-rich cells |
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| US10130409B2 (en) | 2013-11-05 | 2018-11-20 | Myoscience, Inc. | Secure cryosurgical treatment system |
| DE102017009433A1 (en) * | 2017-10-10 | 2019-04-11 | Reinhard Bollert | Pigmentfleckenvereiser |
| JP2019093200A (en) * | 2011-11-16 | 2019-06-20 | ザ ジェネラル ホスピタル コーポレイション | Method and apparatus for cryogenic treatment of skin tissue |
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| CN110461281A (en) * | 2017-05-30 | 2019-11-15 | 雷森斯医疗有限公司 | Medical cooling device and method |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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-
2004
- 2004-11-05 JP JP2004322309A patent/JP4324673B2/en not_active Expired - Lifetime
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| US10524956B2 (en) | 2016-01-07 | 2020-01-07 | Zeltiq Aesthetics, Inc. | Temperature-dependent adhesion between applicator and skin during cooling of tissue |
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| US10682297B2 (en) | 2016-05-10 | 2020-06-16 | Zeltiq Aesthetics, Inc. | Liposomes, emulsions, and methods for cryotherapy |
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| US12076069B2 (en) | 2016-05-13 | 2024-09-03 | Pacira Cryotech, Inc. | Methods and systems for locating and treating nerves with cold therapy |
| US11311327B2 (en) | 2016-05-13 | 2022-04-26 | Pacira Cryotech, Inc. | Methods and systems for locating and treating nerves with cold therapy |
| US11896821B2 (en) | 2016-05-23 | 2024-02-13 | Btl Healthcare Technologies A.S. | Systems and methods for tissue treatment |
| US11623083B2 (en) | 2016-05-23 | 2023-04-11 | Btl Healthcare Technologies A.S. | Systems and methods for tissue treatment |
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| US11878162B2 (en) | 2016-05-23 | 2024-01-23 | Btl Healthcare Technologies A.S. | Systems and methods for tissue treatment |
| US11185690B2 (en) | 2016-05-23 | 2021-11-30 | BTL Healthcare Technologies, a.s. | Systems and methods for tissue treatment |
| US10596386B2 (en) | 2016-07-01 | 2020-03-24 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
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| US11076879B2 (en) | 2017-04-26 | 2021-08-03 | Zeltiq Aesthetics, Inc. | Shallow surface cryotherapy applicators and related technology |
| CN110461281A (en) * | 2017-05-30 | 2019-11-15 | 雷森斯医疗有限公司 | Medical cooling device and method |
| US11464669B2 (en) | 2017-05-30 | 2022-10-11 | Recensmedical, Inc. | Device and method for cooling living tissue |
| US11547602B2 (en) | 2017-05-30 | 2023-01-10 | Recensmedical, Inc. | Device and method for cooling living tissue |
| US12239571B2 (en) | 2017-05-30 | 2025-03-04 | Recensmedical, Inc. | Device and method for cooling living tissue |
| CN107440783B (en) * | 2017-09-19 | 2019-10-11 | 杜忠海 | A kind of insertion type probe for cold therapy of liver cancer |
| CN107440783A (en) * | 2017-09-19 | 2017-12-08 | 杜忠海 | A kind of new insertion type probe for cold therapy of liver cancer |
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| US11134998B2 (en) | 2017-11-15 | 2021-10-05 | Pacira Cryotech, Inc. | Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods |
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| US12102557B2 (en) | 2018-07-31 | 2024-10-01 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
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| US11247063B2 (en) | 2019-04-11 | 2022-02-15 | Btl Healthcare Technologies A.S. | Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy |
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