JP2004300119A - Oral cavity composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oral cavity composition excellent in an effect of cleaning the oral cavity, particularly the oral mucous membrane, the intraoral parenchymal tissue such as the tongue, and an interdental part. <P>SOLUTION: The oral cavity composition comprises a disintegrative gel to clean the intraoral parenchymal tissue or the interdental part. Preferably, the disintegrative gel is obtained by compounding at least one first gelling agent selected from the group consisting of agar, carrageenan, furcellaran, alginic acid, its salt, gellan gum, and pectin with at least one second gelling agent selected from the group consisting of glucomannan, native gellan gum, tara gum. locust bean gum, tamarind, celluloses and the like. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
TECHNICAL FIELD The present invention relates to an oral composition, and more particularly, to an oral composition having an excellent effect of cleaning oral soft tissues (oral mucosa, tongue, etc.) and interdental regions.
[0002]
[Prior art]
Plaques on the oral mucosa (eg, buccal mucosa) and on the tongue are known to cause various infections (eg, candidiasis) and bad breath. Currently, means for removing oral mucosal plaque include toothbrushes, tank cleaners and mouth washes.
[0003]
However, when using a toothbrush or tank cleaner, the buccal mucous membrane is damaged, or when trying to remove the tongue coating, the pharynx is stimulated, and a mouthwash has a poor cleaning effect.
[0004]
On the other hand, physical cleaning means such as an interdental brush and floss have been known for cleaning the interdental portion, but these have had a problem that it takes a long time to clean.
[0005]
An oral cavity cleaning composition using a gel for cleaning the interdental region and the like is known (Patent Document 1 (JP-A-2002-193776) and Patent Document 2 (JP-A-2002-255768)).
[0006]
However, Patent Literature 1 and Patent Literature 2 have problems in the physicochemical properties of the gel such as gel strength, and the cleaning effect is insufficient.
[0007]
An object of the present invention is to provide a composition for the oral cavity which is excellent in the effect of cleaning the oral cavity, particularly the oral soft tissue such as the oral mucosa and the tongue, and the interdental region.
[0008]
[Patent Document 1]
JP-A-2002-193776
[0009]
[Patent Document 2]
JP-A-2002-255768
[0010]
[Means for Solving the Problems]
The present inventors have found that gel strength and viscoelasticity (strain rate), particularly the balance thereof, and the selection / combination of a gelling agent are important for cleaning oral soft tissues and interdental regions.
[0011]
The present invention relates to the following oral compositions.
Item 1. An oral composition containing a disintegrating gel for cleaning oral soft tissues or interdental regions.
Item 2. Disintegrating gel, agar, carrageenan, furceleran, alginic acid and its salts, at least one first gelling agent selected from the group consisting of gellan gum and pectin and glucomannan, native gellan gum, tara gum, locust bean gum, tamarind, cellulose And at least one second gelling agent selected from the group consisting of xanthan gum, pullulan, guar gum, carboxymethylcellulose salt, starch phosphate, polyacrylate, gum arabic, curdlan, gati gum, and aeromonas gum. Item 2. The composition according to Item 1, which is compounded in combination.
[0012]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, the present invention will be described in more detail.
[0013]
The composition of the present invention is suitable for cleaning the oral cavity, particularly for cleaning oral soft tissues and / or interdental regions.
[0014]
Examples of the soft tissue in the oral cavity include the palate, buccal mucosa, tongue, and gums.
[0015]
In the cleaning of the soft tissue in the oral cavity, it is necessary to remove the disintegrable gel so as to come into contact with the soft tissue and wipe off dirt on the soft tissue surface, and the gel strength and the strain rate (viscoelasticity) of the disintegratable gel become important. If the gel strength and the strain rate are appropriate, the gel will come into contact with soft tissue with an appropriate strength, and the gel will be able to wipe off stains on the soft tissue while being distorted. If the gel strength is too high, the gel does not deform when contacting with soft tissue, but breaks, so that the effect of removing dirt becomes insufficient. On the other hand, if the gel strength is too low, it becomes sticky in the mouth, making it difficult to remove dirt. If the strain rate (viscoelasticity) is too small or too large, the power to wipe off dirt becomes insufficient.
[0016]
Similarly, when cleaning the interdental area, if the disintegrating gel is too soft or too brittle, the interdental area cannot be sufficiently cleaned. On the other hand, if the strain rate (viscoelasticity) of the collapsible gel is too strong, it becomes difficult to clean the interdental region. In order to clean the interdental region, the balance between the gel strength and the strain rate (viscoelasticity) of the collapsible gel is very important. When increasing the gel strength, the first gelling agent is suitable, but the strain rate (viscoelasticity) tends to be insufficient. On the other hand, the second gelling agent is suitable for increasing the strain rate (viscoelasticity), but the gel strength tends to be insufficient.
[0017]
Therefore, regardless of whether the interdental region or the oral soft tissue is to be cleaned, the gel strength and the strain rate (viscoelasticity) are within a predetermined range by using the first gelling agent and the second gelling agent together. It is preferable to prepare a disintegrable gel such that
[0018]
In the oral composition of the present invention, the preferred gel strength is 10 to 300 g, more preferably 30 to 250 g, and still more preferably 30 to 200 g.
[0019]
A preferred strain rate is 10 to 70%, more preferably 15 to 60%, and still more preferably 15 to 50%.
[0020]
The preferred gel index of the disintegratable gel of the present invention is 0.1 to 10, more preferably 0.3 to 8, and still more preferably 0.5 to 6.
[0021]
The gel strength, strain rate, and gel index can be measured as follows.
<Gel strength>
Measuring device: San Kagaku Co., Ltd. Total physical property measuring device (SUN RHCO METER CR-2000)
Measurement conditions: Pressure sensitive shaft No. for compression elasticity 1: Contact area φ10mm; Shape Circular sample stage moving speed 10mm / min
Measurement temperature 25 ℃
<Distortion rate>
When the gel strength was measured using the above instrument, the distance that the pressure-sensitive axis penetrated into the gel was measured.
[0022]
Strain rate (%) = 100 × (penetration distance in gel (mm)) / height of gel (mm)
<Gel index>
The gel index is calculated based on the following formula:
Gel index = Penetration distance in gel (mm) / strain rate (%)
Preferred combinations of gelling agents for producing the disintegrating gel of the present invention include agar, carrageenan, furceleran, alginic acid and salts thereof, at least one first gelling agent selected from the group consisting of gellan gum and pectin, Glucomannan, native gellan gum, cod gum, locust bean gum, tamarind, celluloses, xanthan gum, pullulan, guar gum, carboxymethyl cellulose salts, starch phosphate, polyacrylates, gum arabic, curdlan, gati gum and aeromonas gum And a combination with at least one second gelling agent selected from the group consisting of:
[0023]
The total amount of the gelling agent used is usually 0.05 to 3.0% by weight, preferably 0.1 to 1.7% by weight.
[0024]
When the first gelling agent and the second gelling agent are used in combination, the amount of the first gelling agent is 0.01 to 1.0% by weight, preferably 0.05 to 0.5% by weight, Preferably, it is 0.05 to 0.2% by weight, and the amount of the second gelling agent is 0.01 to 2.0% by weight, preferably 0.1 to 1.5% by weight.
[0025]
The first gelling agent: the second gelling agent = 1: 10 to 10: 1 (weight ratio), preferably 1: 5 to 5: 1 (weight ratio).
[0026]
Particularly preferred combinations of gelling agents are
Carrageenan / xanthan gum / locust bean gum;
Gellan gum / xanthan gum / locust bean gum;
Carrageenan / glucomannan;
Gellan gum / tamarind;
Carrageenan / tamarind / hydroxyethylcellulose.
[0027]
The disintegrable gel used in the composition of the present invention can be produced by dissolving the gelling agent in water by heating and cooling. The gelling agent solution can be gelled by adding a polyvalent cation such as a calcium ion, a magnesium ion or an aluminum ion, preferably an alkaline earth metal ion.
[0028]
The cation source is not particularly limited, but includes, for example, water-soluble polyvalent organic or inorganic acids such as calcium lactate, magnesium lactate, calcium gluconate, calcium glycerophosphate, magnesium chloride, calcium chloride, and magnesium sulfate. Metal salts are mentioned, among which salts of organic acids are preferred, and calcium lactate is particularly preferred.
[0029]
The combination of at least one of the above-mentioned gellan gum, pectin, sodium alginate and carrageenan and a polyvalent cation preferably includes, for example, gellan gum and calcium ions, pectin and calcium ions, and carrageenan and calcium ions.
[0030]
The amount of the water-soluble polyvalent metal salt as the cation source can be appropriately set according to the type and amount of at least one of gellan gum, pectin, sodium alginate, and carrageenan, and the desired gel hardness. Usually, it is preferably about 0.01 to 2% by weight, particularly preferably about 0.05 to 1% by weight based on the total amount of the composition. For example, when calcium lactate is used as a cation source, it may be about 0.01 to 1% by weight, preferably about 0.05 to 0.5% by weight, based on the total weight of the composition. . The amount used when another cation source is used can be appropriately set with reference to the above range.
[0031]
The amount of water used when preparing the gel of the composition of the present invention is not particularly limited as long as the desired effect can be obtained, and can be appropriately set, but is usually 30 to 99 based on the total weight of the gel. It is about 9.9% by weight, preferably about 50 to 99.5% by weight, and more preferably about 70 to 99.5%.
[0032]
The pH of the mouthwash composition of the present invention is preferably about 5.0 to 7.5, and more preferably about 5.5 to 7. Buffers can also be used to adjust the pH.
[0033]
The gel of the present invention can be blended with components that can be used in ordinary compositions for cleaning oral cavity.
[0034]
Specifically, examples of the wetting agent include ethanol, glycerin, sorbit, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, erythritol, palatinose, and palatinit.
[0035]
As dispersants, cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose and hydroxyethylcellulose; gums such as tragacanth gum, karaya gum, gum arabic, xanthan gum, locust bean gum; sodium polyacrylate, polyoxyethylene polyoxypropylene copolymer, polyvinyl Synthetic water-soluble polymers such as alcohols, carboxyvinyl polymers, and polyvinylpyrrolidone (usually in an amount of about 0.005 to 1% by weight), and the like.
[0036]
Examples of the surfactant include anionic surfactants such as sodium lauryl sulfate, sodium myristyl sulfate, N-lauroyl sarcosinate, lauroylmethyltaurine, and acyl amino acid salts; sucrose fatty acid esters, decaglyceryl laurate, diethanolamide myristate, Nonionic surfactants such as polyoxyethylene hydrogenated castor oil and the like (usually blended amount 0.05 to 10% by weight).
[0037]
Fluorine compounds such as sodium fluoride, sodium monofluorophosphate and stannous fluoride as active ingredients; enzymes such as dextranase, mutanase, protease and lysozyme; tranexamic acid, ε-aminocaproic acid, aluminum chlorohydroxyallantoin, Allantoin, dihydrocholesterol, glycyrrhizic acids, bisabolol, isopropylmethylphenol, glycerophosphoric acid, chlorophyll, copper gluconate, sodium chloride, water-soluble inorganic phosphate compound, chlorhexidine salts, triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride; Vitamins such as acetic acid-dl-α-tocopherol, pyridoxine acetate, ascorbic acid or a salt thereof; and plant extracts such as thyme and ogre.
[0038]
As a flavoring agent, saccharin sodium, acesulfame potassium, stevioside, glycyrrhizin and its salts, asparatyl phenylalanine methyl ester, menthol, anethole, carvone, eugenol, limonene, peppermint oil, spearmint oil, wintergreen, methyl salicylate, zionyl, thymol, Any flavoring agent such as clove oil, eucalyptus oil, rosemary oil, sage oil, lemon oil, orange oil, ocimene oil, citronellol, and methyl eugenol can be used without any particular limitation.
[0039]
As the colorant, known dyes and pigments can be used alone or in combination of two or more.
[0040]
Further, as a cleaning aid, sedimentable silica, zirconosilicate, aluminosilicate, calcium phosphate, calcium carbonate, aluminum hydroxide, aluminum oxide and the like can be blended (blending amount: 10% by weight or less).
[0041]
The amount of these optional components may be such that the effects of the present invention are not impaired, and may be such that they are usually incorporated into a composition intended to clean the oral cavity.
[0042]
The oral composition of the present invention may use the disintegrating gel obtained as described above as it is, for example, after gelation, stirring, or cut into an appropriate size by passing through a mesh, It may be a gel.
[0043]
In addition, a gel having fluidity can be obtained by discharging the gel from a pump container or by squeezing the gel out from a soft container having a narrow mouth. The composition of the present invention can be used in this way, and the fluid gel thus obtained is also included in the mouthwash composition of the present invention.
[0044]
As described above, the oral cavity cleaning composition of the present invention is to be punctured in the oral cavity, like a normal mouthwash, to wipe off dirt physically attached to the oral soft tissue and the interdental region. And is exhaled from the oral cavity after use.
[0045]
【The invention's effect】
The oral composition of the present invention cleans these parts / tissues while collapsing the gel by contacting the gel with the soft tissue in the oral cavity or by passing the gel through the interdental region, and adhered to the soft tissue. Slime and plaque can be effectively removed, and the interdental cleaning effect can prevent bad breath, caries, gingivitis, periodontitis, and the like.
[0046]
【Example】
Hereinafter, the present invention will be described specifically with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition,% in each example is all weight%.
Examples 1-6 and Comparative Examples 1-2
Using the components shown in Table 1 below, an oral composition of the present invention composed of a disintegrable gel was obtained.
[0047]
The composition for oral cavity was evaluated for gel strength (g), strain rate (%), gel index, ease of mouth washing, cleaning feeling of oral mucosa, and comprehensive evaluation. Table 1 also shows these results.
<Preparation of sample>
Water was added to the gelling agent, and the mixture was heated to about 80 ° C. while dispersing and stirring to dissolve. The other components were added thereto, and the mixture was stirred until it became uniform, and then cooled and solidified to obtain a collapsible gel.
<Gel strength><Strainrate><Gelindex>
The sample prepared by the above method was measured by the method described above.
<Sensory evaluation>
Sensory evaluation was performed by a specialized panel of 10 people.
[0048]
The gel preparation prepared by the above method was crushed to have an average particle size of 10 mm. About 10 ml was contained in the mouth, spread to all corners of the mouth, hit the buccal mucous membrane, the tongue, etc., washed the mouth while passing through the interdental region, and evaluated the feeling of use and the feeling of cleaning according to the following criteria.
* Easy to clean mouth 5; Easy 4; No discomfort 3; I do not understand 2; Somewhat uncomfortable 1; Difficult * Cleaning sensation 5; 2, not so much 1; not at all
[Table 1]

Claims (2)

An oral composition containing a disintegrating gel for cleaning oral soft tissues or interdental regions. Disintegrating gel, agar, carrageenan, furceleran, alginic acid and its salts, at least one first gelling agent selected from the group consisting of gellan gum and pectin and glucomannan, native gellan gum, tara gum, locust bean gum, tamarind, cellulose And at least one second gelling agent selected from the group consisting of xanthan gum, pullulan, guar gum, carboxymethyl cellulose salt, starch phosphate, polyacrylate, gum arabic, curdlan, gati gum, and aeromonas gum. The composition according to claim 1, wherein the composition is combined and combined.