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JP2003508107A - 液体塞栓組成物の注入制御装置 - Google Patents

液体塞栓組成物の注入制御装置

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Publication number
JP2003508107A
JP2003508107A JP2001519825A JP2001519825A JP2003508107A JP 2003508107 A JP2003508107 A JP 2003508107A JP 2001519825 A JP2001519825 A JP 2001519825A JP 2001519825 A JP2001519825 A JP 2001519825A JP 2003508107 A JP2003508107 A JP 2003508107A
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catheter
liquid
liquid embolic
delivery system
embolic composition
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JP2003508107A5 (ja
Inventor
アンドリュー・エイチ・クラッグ
ブレア・ディ・ウォーカー
ジョン・パール・Ｉｉ
マイケル・ジョーンズ
ジョージ・ロバート・グリーン
ジョージ・ウォレス
リチャード・ジェイ・グレフ
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マイクロ・セラピューティクス・インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
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    • A61B17/12177—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
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    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
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    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B2017/1205—Introduction devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12059—Joint of soluble material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12063—Details concerning the detachment of the occluding device from the introduction device electrolytically detachable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
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    • A61M2025/0036—Multi-lumen catheters with stationary elements with more than four lumina
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
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    • A61M25/0097—Catheters; Hollow probes characterised by the hub

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Abstract

(57)【要約】 本発明は、液体塞栓を塞栓領域以外で凝固することが防止されるように、注入される液体塞栓組成物を捕捉するための閉じ込め部材に関する。送込みシステムは、液体塞栓組成物をキャビティへ送り込むための管腔を有するカテーテルと、カテーテルの遠位端に位置する閉じ込め部材であって、カテーテルの管腔を介して送り込まれる液体塞栓組成物を捕捉するように形作られた閉じ込め部材とを備える。閉じ込め部材は、ブラシ、巣、スポンジ、綿棒、フレキシブル袋等の液体塞栓組成物が注入される形状に形成されている。液体塞栓組成物は、凝固中に閉じ込め部材を用いて捕捉され若しくは網で捕えられ、液体塞栓を包み、液体塞栓組成物が血液中に流れていくのが防止されている。

Description

【発明の詳細な説明】
【０００１】
【発明の属する技術分野】
本発明は、液体塞栓組成物の患者への注入を制御する装置に関するものであり
、特に、凝固中及び凝固後の液体塞栓組成物の閉じ込め及び束縛のための装置に
関するものである。制御注入装置は、制御された方法で塞栓組成物の送り込みに
使用されるカテーテルシステムに組み込まれてもよい。
【０００２】
【従来の技術及び発明が解決しようとする課題】
多くの臨床的状況において、出血の制御若しくは防止、組織への血液の供給の
防止、動静脈奇形（ＡＶＭｓ）の処置、及び、動脈瘤内の血液流の遮断等の種々
の目的で、血管を選択的に閉塞されるのは望ましい。所定のポリマー組成物、微
粒子、及び／又は、シリコーンバルーン、金属コイル、ＰＶＡ粒子、ゼラチン等
を含む硬化材料を使用することによって、血管の塞栓を実施し、血管中の血液の
流れを選択的に遮断してきた。しかしながら、これらの塞栓法は欠点を有する。
【０００３】 頭蓋内動脈瘤は血液が異常に詰め込まれた血管壁の膨張であり、このために、
多量の出血して血管が破裂したり、周囲の脳組織へ損傷若しくはその死へとつな
がる。従来、頭蓋内動脈瘤は、切り取られる動脈瘤のネックの回りに金属クリッ
プを取り付けて動脈瘤へ血液が流れ込むのを防止することによって、破裂の危険
を低減するように手術で切り取られてきた。しかしながら、動脈瘤の位置及び形
状に起因して、又は、患者の状態が頭蓋の手術を許さないため、多くの動脈瘤は
外科的に取り扱うことはできない。
【０００４】 動脈瘤が外科的に扱うことができないか、又は、手術が危険すぎるか若しくは
侵襲的過ぎるときには、動脈瘤はコイルを用いて血管内で処置してもよい。内部
聴診法によって動脈瘤のサイトにカテーテルを延ばし、かつ、白金、ステンレス
鋼若しくはタングステンのコイルのような単一の若しくは他の多重の金属コイル
をカテーテルを介して動脈瘤に通すことによって、コイルを動脈瘤に設置する。
動脈瘤内に設置されたコイルは、動脈瘤を塞ぐ血栓を形成し、血液が動脈瘤に流
れ込むのを防止する。コイルを用いて頭蓋内動脈瘤を処置することによって、動
脈瘤を動脈循環から孤立させ、破裂及び動脈瘤のの防止に役立つ。しかしながら
、頭蓋内動脈瘤を処置するために金属コイルを使用することは永久的な解決には
ならない。というのは、血液凝固機能の動的な性質のためにコイルの回りの血液
凝塊（クロット）は溶解若しくは分解するからである。一旦、血液凝塊が動脈瘤
溶解に置いてコイルの回りに形成されると、コイルはもはや動脈瘤を塞ぐ機能を
発揮し得ない。また、コイルは動脈瘤から除去され、移動し、又、患者の血液の
流れに入って、血管系内の他の位置で閉塞を生じさせてもよい。コイルは、望ま
ない塞栓の下流への流れを生ずる血液の流れへ延びるループも形成できる。
【０００５】 動脈瘤を塞ぐためのコイルの使用に関連する他の欠点は、コイルが長時間にわ
たり圧縮することが公知であり、その後の動脈瘤の成長のためのキャビティを残
る。また、その後の外科的なクリッピング処置が保証されると、コイルの塊の上
にクリップを配置することが難しくなり得る。
【０００６】 動脈瘤を処置する他の方法には、シリコーンバルーンで動脈瘤を閉塞すること
、あるいは、特別の材料で動脈瘤を充填することが含まれる。
【０００７】 大きなネックを有する動脈瘤は、外科的なクリッピングによって、又は、コイ
ルによって容易に処置されない。というのは、動脈瘤ネックは外科的に完全にク
リップすることができない形状を有するか、又は、ネックが特に大きいときには
コイルが動脈瘤から押しのけられる傾向があるからである。
【０００８】 外科的クリッピング及びコイル技術を用いて問題を扱う頭蓋内動脈瘤を処置す
る一の最小の侵襲性の方法には、動脈瘤を閉塞するために動脈瘤において凝固す
る液体塞栓組成物の血管内注入を含む。通常、液体塞栓組成物は生体適合性溶剤
で溶解する、水不溶性、生体適合性、非生物分解性のポリマーを含む。一旦、液
体塞栓組成物を動脈瘤に注入すると、生体適合性溶剤は血液に放散していき、ポ
リマーは凝固して動脈瘤を通る血流を押しのける。これらの液体塞栓組成物は、
内科医が蛍光透視法によって塞栓処置を見ることができる放射線不透過性材料を
含むことが好ましい。
【０００９】 液体塞栓組成物を動脈瘤に送り込む前に、動脈瘤及び送込み装置は、液体塞栓
組成物が重力によって動脈瘤へ送り込まれ、凝固し、動脈瘤に残るように配置さ
れるのが好ましい。これは、動脈瘤ネックを用いて動脈瘤を位置付けるために患
者の位置をしばしば操作することを意味する。液体塞栓組成物を動脈瘤に送り込
むと、溶剤はポリマー材料から放散し、血液の流れにおいて除去されて、それに
よって動脈瘤内においてポリマー材料が凝固することになる。
【００１０】 液体塞栓組成物が血管に注入される割合及び現在の血流の量に依存して、ポリ
マーは、溶剤が血液の流れの中に放散していく間のしばらくの間には液体のまま
であってもよい。また、注入点での溶剤の濃度は、凝固していないポリマー材料
の小糸（小ストリング）をポリマー塊から分離し、ポリマーが望まない血管位置
を閉塞し得る血液の流れに運び去られてもよい。
【００１１】 さらに、重力に依存しない位置にある動脈瘤が液体塞栓組成物を動脈瘤から血
液の流れの中に流すことなく充填することができるように、注入の間、ポリマー
材料の凝固を制御する装置又は方法を提供することは望ましい。ポリマーストリ
ングを血液の流れに運ばれることを防止することも望ましい。
【００１２】
【課題を解決するための手段】
本発明は、液体塞栓を塞栓領域以外で凝固することが防止されるように、注入
される液体塞栓組成物を捕捉するための閉じ込め部材に関する。
【００１３】 本発明の一態様では、液体塞栓送込みシステムは、液体塞栓組成物をキャビテ
ィへ送り込むための管腔を有するカテーテルと、カテーテルの遠位端に位置する
閉じ込め部材と、凝固した塞栓組成物の塊からカテーテルを分離するために、液
体塞栓組成物の凝固の後に、カテーテルから閉じ込め部材を完全に引き離す引き
離し部材と、を含む。閉じ込め部材は、カテーテルの管腔を介して送り込まれる
液体塞栓組成物を捕捉するように形作られている。
【００１４】 本発明の他の態様では、体内の塞栓サイトに液体塞栓組成物を閉じ込める方法
であって、カテーテルを用いて体内の塞栓サイトに液体塞栓組成物を送り込む段
階と、閉じ込め部材を用いて凝固の間に液体塞栓組成物を閉じ込める段階と、凝
固した塞栓組成物の塊からカテーテルを離すために、液体塞栓組成物の凝固の後
にカテーテルから閉じ込め部材を引き離す段階と、を備えている。
【００１５】
【発明の実施の形態】
本発明を、添付図面で図示した好適な実施形態を参照して説明する。
【００１６】 液体塞栓送込みシステムは管腔を有するカテーテルを含み、その管腔を通して
液体塞栓組成物を体内の塞栓サイトに送り込むものである。フレキシブル袋のよ
うな閉じ込め部材をカテーテルの遠位端（distal end）に配置させ、液体塞栓組
成物を閉じ込め部材に注入する。液体塞栓組成物は凝固（固化）中は閉じ込め部
材に捕捉されあるいは調和して、液体塞栓を含み、液体塞栓組成物が血液の流れ
に入るのが防止される。液体塞栓組成物を閉じ込め部材の好適な実施形態を、図
面を用いて以下に説明する。
【００１７】 本発明を説明する前に、以下の用語を詳細に定義する。
【００１８】 “液体塞栓組成物”は、塞栓サイトで注入されかつ固化して塞栓サイトを部分
的に若しくは全部を塞栓する流体組成物を称するものである。
【００１９】 “塞栓する”又は“塞栓”は、例えば動脈瘤の場合に動脈瘤への血流及び動脈
瘤における圧力がやむように動脈瘤サックを充填するか若しくは埋め込むか及び
／又は凝塊形成を促進し、かつ、動静脈奇形（ＡＶＭｓ）及び動静脈異常導管（
ＡＶＦｓ）の場合に血流を制御／新ルート変更して適当な組織灌流を可能とする
ように栓若しくは凝塊を形成する血管又は組織へ流体組成物を注入する工程を称
するものである。塞栓は、障害（例えば、器官出血、胃腸出血、血管出血、動脈
瘤に関わる出血）に起因する出血を防止し又は制御するのに用いてもよい。また
、塞栓は、血液供給を遮断することによって、病気の組織（例えば、腫瘍等）を
切除するの用いることが可能である。
【００２０】 本発明で使用する液体塞栓組成物は、体内で固化するいかなる生体適合性組成
物、例えば、エタノール、ジメチルスルホキシド（ＤＭＳＯ）、乳酸エチル、ア
セトン等の適当な生体適合性溶媒と組み合わせた生体適合性ポリマーであっても
よい。塞栓組成物の例としては、１９９７年９月１６日に特許された米国特許第
５，６６７，７６７号明細書、１９９６年１２月３日に特許された米国特許第５
，５８０，５６８号明細書、および、米国特許出願第０８／６８８，０５０号明
細書に記載され、それら明細書の内容の全てはここに組み込まれるものとする。
他の液体塞栓組成物には、ポリーマ（polyhma）ようなヒドロゲル、他のポリア
クリル酸塩、セルロシックス（cellulosics）、他の天然ポリマー及びプレポリ
マー、シアノアクリル酸塩、ウレタン、及び、シリコーンを含む。
【００２１】 使用される溶媒がＤＭＳＯである本発明の好適な実施形態では、溶媒に接触す
る送込みシステム要素はＤＭＳＯ互換である。ＤＭＳＯ互換カテーテル材料の例
は、ポリエチレン若しくはポリプロピレンのようなポリオレフィン、ＰＴＦＥ及
びＥＴＦＥのようなフルオロポリマー、及び、シリコーンを含む。
【００２２】 図１及び図２に示した液体塞栓送込みシステムは、細長フレキシブルカテーテ
ル１０とカテーテル内に配備された閉じ込めブラシ１２とを含んでいる。カテー
テル１０は、オーバー・ザ・ワイヤー・カテーテル（over the wire catheter）
、流れ指向カテーテル、又は液体塞栓組成物を塞栓サイトに送り込むことが可能
な他のタイプのカテーテルであってもよい。ブラシ１２は、患者の体内の外に延
びるカテーテルの近位端（proximal end）からブラシを操作するためのカテーテ
ル１０の管腔を通って延びる細長フレキシブルシャフト１４を含む。ブラシ１２
は、シャフト１４の遠位端から実質的に径方向に延びる複数のフィラメント１６
を含む。
【００２３】 使用の際には、ブラシが完全に若しくは実質的に管腔内に位置する図１で示し
たような引っ込み位置においてブラシ１２を用いて塞栓サイトにカテーテル１０
を送り込む。次いで、シャフト１４はカテーテル１０内で遠位端に移動し、カテ
ーテルの遠位端からブラシ１２を延ばす。ブラシ１２は、カテーテル１０の管腔
から出る液体塞栓組成物がブラシに捕捉されるように配置する。好ましくは、ブ
ラシは、カテーテルの遠位端から約0mmないし5mm、さらに好ましくは、約1mmか
ら4mmの位置に、特別の塞栓サイトに依存する正確な位置で配置する。
【００２４】 一旦、ブラシ１２が配置されると、ブラシ１２のシャフト１４が延びる同じ管
腔を介して、又は、カテーテルの第２の平行管腔を介して、液体塞栓組成物がカ
テーテル１０を介して注入される。液体塞栓組成物がカテーテルの下方へ送り込
まれると、カテーテルの遠位端を出る液体がブラシ１２の単繊維（filament）１
６に注入される。溶剤が液体塞栓組成物から散り始め、ポリマー材料はブラシの
毛に沈着し、調和する。その後の液体塞栓材料の注入は、塞栓サイトでブラシを
囲繞する固化された塞栓材料の質量を増加する。液体塞栓組成物の注入は、塞栓
サイトが完全に塞がれるまで続けられる。ブラシ１２は、沈着材料を含み捕捉す
るように作用し、重力及び血流の効果によって、ポリマー材料が塞栓サイトから
運び去られることになるのを防止する。
【００２５】 液体塞栓組成物がカテーテル１０を通って送り込まれ、ブラシ１２の回りに固
形物を形成した後、固形物が以下に記載するような機械的、電気的若しくは化学
的切り離しシステムのような切り離し機構によってカテーテル及びブラシシャフ
ト１４から切り離される。
【００２６】 ブラシ１２は、カテーテル１０の管腔を介して延びる細長フレキシブルシャフ
ト１４に取り付けられるように記載したが、ブラシは短いシャフトのような取付
部材によって直接カテーテルの遠位端に連結されてもよい。ブラシ１２がカテー
テル１０の端部に直接連結するとき、カテーテルとブラシとが一緒に単一のユニ
ットとしてカテーテル１０より大きな直径の独立導入カテーテルを介して導入さ
れてもよい。液体塞栓組成物の送り込みの後、ブラシ１２はカテーテル１０から
分離し又はカテーテルの全遠位端が分離可能でもよい。
【００２７】 ブラシ１２の単繊維１６は、ナイロン、ポリエチレン、ポリプロピレン、ポリ
エステル、ＰＴＦＥ、ダクロン（登録商標）等のような材料から形成されたフレ
キシブル部材であるのが好ましい。単繊維はソフトで、フレキシブルで、生体適
合性があり、ＤＭＳＯ互換であるのが好ましい。単繊維のサイズは応用に依存し
て変化してもよいが、適当な単繊維の一例としては、約75μｍから約500μｍ、
好適には約150μｍから約250μｍの直径、かつ、約1mmから約30mm、好適には約2
mmから約10mmの導管サイトの内径に依存した長さを有するものが挙げられる。
【００２８】 図３及び図４は、ワイヤ２０がカテーテル２２の遠位端を出るときにワイヤが
塞栓サイトで巣状構造を形成するものであって、ワイヤ２０がカテーテル２２の
管腔を介して送り込まれる液体塞栓送込みシステムの他の実施形態を示している
。ワイヤ２０は、ワイヤがカテーテル２２の遠位端から外へ送り込まれるときに
巣状部材２４を形成する曲率を有するように予備成形（プレフォーム）される。
巣状部材２４の形状は通常、塞栓サイトの形状に合致する。例えば、動脈瘤を処
置するときに巣状部材２４が動脈瘤の形状に合致する。液体塞栓組成物はその後
、カテーテル管腔を介して送り込まれ、ワイヤ巣状部材２４に捕捉され、その上
に沈殿（沈着）する。上述のような実施形態においては、塞栓の完了後、塞栓材
料の固形物及びワイヤ巣状部材２４がカテーテルから分離される。
【００２９】 ワイヤ２０は、巣状部材２４が特別に予め決められた形状をとるようになるよ
うに予備成形されてもよい。巣状部材形状の例としては、図４で示したランダム
に曲がったワイヤ形状、及び、コイル若しくはらせん形状を含む。ワイヤ２０は
、ステンレス鋼、白金、ニチノール（Nitinol：登録商標）、金、タングステン
等のような生体適合性材料から成ってもよい。また、ニチノールのような形状記
憶材料からワイヤ２０を形成するのに望ましい。
【００３０】 スポンジ用部材３０及びカテーテル３２を含む本発明の他の実施形態を図５及
び図６に示す。図５に示すように、スポンジ３０は、カテーテルを塞栓サイトに
送込む間、カテーテル３２の管腔内に圧縮されている。一旦、カテーテル３２の
遠位端を塞栓サイトに若しくは塞栓サイト近傍に配置すると、スポンジ３０はカ
テーテル管腔３２を介して延び、スポンジ３０に連結されたプランジャ若しくは
ロッド３４によってカテーテルから出てくる。一旦、スポンジ３０がカテーテル
３２から出ると、スポンジ３０は図６に示したような外形へと膨張する。膨張ス
ポンジ３０は、液体塞栓組成物が注入される複数の大きな穴３６及び小さめの孔
を含む。
【００３１】 図１及び図２の実施形態に示すように、図５及び図６のスポンジ３０は、プラ
ンジャ３４への代わりに、カテーテル３２の端部へ固定してもよく、カテーテル
及びスポンジ全システムは、導入カテーテルを介して塞栓サイトへ送り込んでも
よい。次いで、液体塞栓組成物をカテーテル３２によってスポンジの外部若しく
は内部へ送り込んでもよい。一旦、塞栓物がカテーテル管腔を介して液体塞栓組
成物を注入することによって、スポンジ３０の回りに形成されると、塞栓物はカ
テーテル３２から分離され、カテーテル除去後に塞栓サイト内に残る。カテーテ
ル３２及びロッド３４から固形化した塞栓物の分離は、以下に記載するように、
機械的、電気的若しくは化学的分離によって実施する。
【００３２】 図５及び図６の実施形態によるスポンジ部材３０は、高い多孔性を有する生体
適合性でかつ連続気泡性の圧縮材料、例えば、ポリエチレンスポンジ、ポリプロ
ピレンスポンジ、ポリウレタンスポンジ３０、ＰＶＡ、フルオロポリマー等から
成る。スポンジ３０の寸法及び形状は、特別な塞栓サイト内に適当に合うように
変更する。スポンジ材料は、動脈瘤を十分に充填する生体適合性でＤＭＳＯ互換
の無毒なソフト材料であるのが好ましい。スポンジの膨張率は、約５：１から２
０：１であるのが好ましく、約１０：１であればさらに好ましい。
【００３３】 図７及び図８は、液体塞栓組成物を捕捉する閉じ込め部材が繊維材料の綿棒形
状部材４０である本発明の他の実施形態に関するものである。綿棒形状部材４０
は、押し込み具若しくはロッド４４によってカテーテル４２の管腔内で圧縮され
該管腔から出てもよいし、又は、カテーテルの遠位端に永久的に固定し、導入カ
テーテルを介して挿入してもよい。カテーテル４２を介して送られる液体塞栓組
成物は、綿棒形状部材４０及びその回りに捕捉される。さらなる塞栓組成物は、
綿棒形状部材４０の傍に備えたコアの回りのシェルで凝固する。綿棒形状部材４
０に対する適切な材料は、ポリエステル、ＰＴＦＥ、絹、ダクロン（登録商標）
、ポリエチレン、ナイロン、フルオロポリマー、綿のような生体適合性材料を含
む。綿棒４０の形状及び寸法は、塞栓サイトの特別な形状と寸法に対応するよう
に変更してもよい。
【００３４】 図９及び図１０で示したように、液体塞栓送込みシステムの他の実施形態は、
カテーテル５２の管腔を介して送り込まれる液体塞栓組成物にアタックする帯電
部材又は磁石のようなノード５０を含む。ノード５０は、カテーテル管腔を介し
て延びるロッド５４によって、図９で示した引っ込み位置から図１０で示した延
びた位置まで可動であるのが好ましい。ポリマー組成物は、ノードにアタックす
る磁性粒子を含むのが好ましい。ノード５０は概して塞栓サイトの中心に位置し
、液体塞栓剤はノードの回りのシェルで凝固する。
【００３５】 図１１から図１３は、図３及び図４について上述したきたように、ワイヤネス
ト５４を有する液体塞栓送込みシステムを有する動脈瘤処置法を図示している。
図１１で示したように、カテーテル２２は動脈瘤６２のネック６０に若しくはネ
ックの近傍に位置し、動脈瘤内にワイヤネスト（ワイヤの巣）２４を形成するた
めにワイヤ２０はカテーテル２２の管腔を通っていく。次いで、液体塞栓材料は
カテーテル２２の管腔から注入され、凝固中ワイヤネスト２４によって捕捉され
る。動脈瘤６２が図１２に図示したような液体塊６４で完全に若しくは実質的に
充填されるまで、液体塞栓材料の注入は続く。次いで、化学的、機械的、若しく
は電気的引き離し手段によって動脈瘤内に液体塞栓材料の固化した塊６４からカ
テーテルを引き離す。例えば、ワイヤが液体塞栓塊に入る位置でワイヤを壊すた
めにカテーテル管腔内でワイヤ２０を近位に引く間、カテーテル２２を静止して
おくことによって、塞栓組成物の塊６４を引き離してもよい。次いで、液体塞栓
塊６４とワイヤネスト２４とを動脈瘤における塊内に埋め込まれたままにして、
カテーテル２２及びワイヤ２０を塞栓サイトから除去する。上述のように、壊れ
たワイヤ２０は、塞栓塊６４をカテーテル２２から分離するために、ワイヤ２０
を押し具として用いてもよい。動脈瘤を処置するこの方法は、他の塞栓処置に対
して用いてもよい。
【００３６】 液体塞栓組成物の注入によって、塞栓塊の寸法が増大するにつれて開始核から
連続的なシェルが形成されるように、本発明による液体塞栓組成物を構成しても
よい。また、外皮を最初に形成し、塞栓が塊内にさらに追加して外皮が膨張する
ように、液体塞栓は閉じ込め部材の中心から注入されてもよい。
【００３７】 図１４から図１６は、カテーテル７２の遠位端に固定されるフレキシブル袋７
０を含む液体塞栓送込みシステムを図示する。フレキシブル袋７０のエッジ７８
は、公知の方法でカテーテル遠位先端の外側に固定され、それによってフレキシ
ブル袋７０はカテーテルの出口を囲繞する。遠位端に固定されたフレキシブル袋
７０を有するカテーテル７２は、カテーテル７２より大きめの直径を有する導入
カテーテル７６を介して塞栓サイトに送られる。一旦フレキシブル袋７０を動脈
瘤内のような塞栓サイト内に配置すると、液体塞栓組成物をカテーテル管腔を介
して注入される。
【００３８】 フレキシブル袋７０は、液体塞栓組成物の沈殿物に対して実質的に不透過性の
膜若しくは織物材料から成り、一方、溶剤は透過可能であって溶剤はフレキシブ
ル袋に注入される液体塞栓組成物から散逸することができる。フレキシブル袋７
０を形成するのに用いてもよい生体適合性材料の例は、ポリエステル、ＰＴＦＥ
、ウレタン、ダクロン（登録商標）、ナイロン、ポリエチレン、フルオロポリマ
ー、シリコーン等を含む。実施形態では、フレキシブル袋は、塞栓組成物を注入
するほどバッグの径を増加することができる構造を有する網のバッグである。網
の材料は非弾性的であってもよく、また、弾性的でバルーンのように作用するも
のでもよい。網は溶剤をバッグの外へ放出させることができる一方、バッグの構
造は塞栓材料のフィンガ（指状のもの）若しくはストランドが塞栓サイトから出
ていくのを防止する。一旦、カテーテルが塞栓サイトから引き抜くことができる
ように塞栓が完了すると、フレキシブル袋７０はカテーテル７２の遠位端から取
り外し可能である。
【００３９】 本発明のカテーテルから上述のような一の閉じ込め部材を引き離す方法は、機
械的、電気的、又は化学的のいずれかであってもよい。機械的に引き離す方法の
一例には、カテーテルの管腔を介して延びるプランジャ部材を用いる等して、カ
テーテルの遠位先端から塞栓材料と閉じ込め部材を力学的に引き離すことが含ま
れる。また、外側カテーテルスリーブはカテーテルの遠位先端から塊を引き剥が
すように用いてもよい。機械的引き離しは、種々のインターロック、押し込み、
捻り、及び、施錠等の動きによって実施することもできる。
【００４０】 電気的引き離しは、閉じ込め部材とカテーテルとの間に連結部に形成するもの
であって、弱い部分電流の印加によって容易に蒸発可能な弱い部分を設けること
によって実施してもよい。例えば、９Ｖの電源によって引き離しのために約0.3
ｍＡの電流を流すものでもよい。電気的引き離し機構の一例は、参考文献として
本明細書に組み込まれている米国特許第５，９２８，２２６号明細書に記載され
ている。
【００４１】 化学的引き離し機構では、カテーテルと閉じ込め部材との間の送り込みシステ
ムに、又は、カテーテルの遠位端に可溶性引き離し部分を含む。可溶性引き離し
部分は、カテーテルを介して生体適合性薬品の注入によって、溶解（分解）し、
軟化し、膨張し、劣化し、若しくは他に変化する。化学的引き離しシステムの例
としては、ＤＭＳＯによって溶解するポリマー部分、フッ素化炭化水素によって
溶解するナイロン部分、食塩水若しくは上述の他の生体適合性溶剤によって溶解
される部分のような可溶性引き離し部分を含む。
【００４２】 図１７から図２０は、液体塞栓組成物の注入の制御を改善するために、動脈瘤
への若しくは動脈瘤からの血流を妨害する液体塞栓送込みシステムを図示してい
る。動脈瘤ネックを介して動脈瘤への若しくは動脈瘤からの血流の妨害によって
、動脈瘤内において弱い乱れ若しくは“平穏な”流れ環境が形成され、塞栓材料
による動脈瘤への充填を改良することが可能となる。
【００４３】 図１７で示したように、送込みシステム１００は、動脈瘤ネック９２を有する
動脈瘤９０のような塞栓サイトに設置する。送込みシステムは２つの管腔、すな
わち、液体塞栓組成物の送込み用の内側管腔１０２と動脈瘤ネック９２で血流を
分断させるために用いられる塩水等の流体の注入用の外側管腔１０４とを有する
。送込みシステム１００は、内側カテーテル１０６と、該内側カテーテル１０６
の周囲に同心で配置されかつ動脈瘤ネック９２に配置することができる複数の側
部ポート１１０を有する外側カテーテル１０８とから成る。外側カテーテル１０
８の遠位端は内側カテーテル１０６の外側部を用いて液密シールを形成する。外
側カテーテル１０８のこの遠位端は内側カテーテルに永久接続されてもよいし、
又は、バルブ部材を用いて若しくは用いないで内側カテーテルに対して滑動可能
であってもよい。内側カテーテル１０６及び外側カテーテル１０８は、それらカ
テーテルの位置を視覚化するために放射線不透過性マーカー１１２を備えてもよ
い。また、放射線不透過性マーカーは、外側カテーテル１０８の遠位端でのフュ
ーズ接合点の２つの管の間で挟んでもよい。
【００４４】 側部孔１１０は、外側カテーテル１０８の回りに離間して配置し、比較的短い
軸方向長の領域内に位置するのが好ましい。使用の際には、送込みシステム１０
０は、内側カテーテル管腔１０２をガイドワイヤ管腔として用いて、ガイドワイ
ヤにわたって動脈瘤にガイドされる。内側管腔の先端は動脈瘤のドーム内に配置
し、側部孔１１０は動脈瘤ネック９２近傍に位置する。次いで、ガイドワイヤを
除去し、分断流体（disruption fluid）が外側カテーテル１０８を介して注入さ
れ送込み装置の側部孔１１０から出てくる。分断流体は、塩水、造影剤、若しく
はそれらの混合物等のいずれかの生体適合性流体であってもよい。動脈瘤ネック
で血流の最適分断が生ずるように、分断流体の流れを視覚化し、調整する。次い
で、動脈瘤９０が充填され、塞栓組成物が凝固するまで、カテーテル１０６の中
心の管腔１０２を介して液体塞栓材料を注入する。
【００４５】 本発明の一実施形態では、内側カテーテル１０６は、液体塞栓組成物が注入さ
れる遠位端と混乱側部孔１１０との間の距離の調整ができるように、外側カテー
テル１０８に対して滑動可能である。このような送込みシステム１００を調整す
る能力は、動脈瘤の寸法が変化するので役に立つ。外側カテーテル１０８の遠位
端のバルブによって、流体の漏れなしで、外側カテーテルが内側カテーテルに対
して軸方向に容易に滑動することができる。
【００４６】 図１８から図２０は、分断流れのパターンをを制御できる送込みシステム１２
０の他の実施形態を図示している。多くの動脈瘤９０のネック９は非円形若しく
は楕円形断面を有するので、送込みシステムの周縁の回りの異なる側部孔からの
動脈瘤ネック分断流体の流量を変化させることが望ましい。言い替えると、楕円
ネックの長軸の方向に向いた側部孔での分断流体流を増加する一方、楕円ネック
の短軸のの方向に向いた側部孔での流れを減少するのが望ましい。
【００４７】 図１８は、楕円動脈瘤ネック９２を有する動脈瘤９０と液体塞栓組成物及び分
断流体を動脈瘤へ送り込むための送込みシステム１２０とを図示している。送込
みシステム１２０は、中央管腔１２４と複数の周囲管腔１２６とを有する細長カ
テーテル１２２を含む。周囲管腔１２６は中央管腔１２４の回りに配置し、それ
ぞれは分断流体の送込み用側部ポート１２８を含んでいる。図１９はＡ−Ａ線に
沿ったカテーテル１２２の断面であって、中央管腔１２４と複数の周囲管腔１２
６とを図示する。
【００４８】 カテーテル１２２の近位端では、中央管腔を液体塞栓組成物の源に連結するた
めにために流体連結１３０を備えている。複数の周囲管腔１２６を分断流体の源
に連結するために、流体連結１３２も備える。比較的変動し易い速度で異なる周
囲の管腔１２６への混乱の送り込みを制御するためにマニホルド１３４と複数の
バルブとを備える。マニホルド１３４とバルブとは、動脈瘤ネック９２での異な
る側部孔１２８から送られる流体が図２０で示したように注意深く制御すること
ができるように、流体の送り込みのための流れ規制手段を備える。
【００４９】 動脈瘤ネック混乱側部流を有する液体送込みの他の実施形態では、側部孔の一
又は二以上の列を備えてもよい。これらの側部孔の列は、動脈瘤のちょうど内側
若しくは外側に配置し、ネックを介した血流をさらに混乱させてもよい。
【００５０】 本発明を好適な実施形態を参照して詳細に説明してきたが、本発明を逸脱する
ことなく、種々の変更及び変形も可能であることは当業者には明らかである。
【図面の簡単な説明】
【図１】 引っ込んだ位置にあるマルチフィラメントブラシを有する液体
塞栓送込みシステムの第１の実施形態の側断面図である。
【図２】 延びた位置にあるマルチフィラメントブラシを有する図１の送
込みシステムの側断面図である。
【図３】 巣の形成前の第２の実施形態による送込みシステムの側断面図
である。
【図４】 形成された巣を有する図３の送込みシステムの側断面図である
。
【図５】 引っ込んだ位置にあるスポンジを有する第３の実施形態による
送込みシステムの側断面図である。
【図６】 延びた位置にあるスポンジを有する図５の送込みシステムの側
断面図である。
【図７】 引っ込んだ位置にある綿棒状部材を有する第４の実施形態によ
る送込みシステムの側断面図である。
【図８】 延びた位置にある綿棒状部材を有する図７の送込みシステムの
側断面図である。
【図９】 引っ込んだ位置にある磁性部材を有する第５の実施形態による
送込みシステムの側断面図である。
【図１０】 延びた位置にある磁性部材を有する図９の送込みシステムの
側断面図である。
【図１１】 図３及び図４の送込みシステムによって処置された動脈瘤の
側断面図である。
【図１２】 動脈瘤を充填する液体塞栓材料の塊を有する動脈瘤の側断面
図である。
【図１３】 送込みシステムが液体塞栓材料の塊から引き離された後、動
脈瘤の側断面図である。
【図１４】 引っ込んだ位置にあるフレキシブル袋を含む第６の実施形態
による送込みシステムの側断面図である。
【図１５】 延びた位置にあるフレキシブル袋を有する図１４の送込みシ
ステムの側断面図である。
【図１６】 液体塞栓組成物がフレキシブル袋内で凝固した図１４の送込
みシステムの側断面図である。
【図１７】 動脈瘤ネック流れ分断システムと共に示す動脈瘤の側断面図
である。
【図１８】 動脈瘤ネック流れ分断システムの他の実施形態を示す動脈瘤
の側断面図である。
【図１９】 図１８のＡ−Ａ線に沿った断面図である。
【図２０】 図１８のＢ−Ｂ線に沿った断面図である。
【符号の説明】
１０ カテーテル １２ 閉じ込めブラシ ２０ ワイヤ ２２ カテーテル ２４ ワイヤ巣状部材 ３０ スポンジ ３２ カテーテル ４０ 綿棒形状部材 ４２ カテーテル ６２ 動脈瘤 ６４ 塞栓組成物の塊 ７０ フレキシブル袋 ７２ カテーテル ７６ 導入カテーテル ９０ 動脈瘤 １００ 送込みシステム １０２ 内側管腔 １０４ 外側管腔 １０６ 内側カテーテル １０８ 外側カテーテル １１０ 側部孔 １１２ 放射線不透過性マーカー
───────────────────────────────────────────────────── フロントページの続き (72)発明者 ジョン・パール・ＩＩ アメリカ合衆国・オハイオ・44108・ブラ テナール・スリー・ウェンデン・コート （番地なし) (72)発明者 マイケル・ジョーンズ アメリカ合衆国・カリフォルニア・ 92624・カピストラノ・ビーチ・カミノ・ エル・モリーノ・34441 (72)発明者 ジョージ・ロバート・グリーン アメリカ合衆国・カリフォルニア・ 92626・コスタ・メサ・ジャバ・ロード・ 3019 (72)発明者 ジョージ・ウォレス アメリカ合衆国・カリフォルニア・ 92679・コート・デ・カーザ・テン・ブレ ンターノ・ドライヴ（番地なし) (72)発明者 リチャード・ジェイ・グレフ アメリカ合衆国・フロリダ・33706・セイ ント・ピート・ビーチ・アルトン・ドライ ヴ・2891 Ｆターム(参考） 4C060 DD03 DD48 MM25 4C081 AC08 AC10 CE03 CG05 DA06

Claims (19)

    【特許請求の範囲】
  1. 【請求項１】 液体塞栓組成物をキャビティへ送り込むための管腔を有す
    るカテーテルと； カテーテルの遠位端に位置する閉じ込め部材であって、カテーテルの管腔を介
    して送り込まれる液体塞栓組成物を捕捉するように形作られた閉じ込め部材と； 凝固した塞栓組成物の塊からカテーテルを分離するために、液体塞栓組成物の
    凝固の後に、カテーテルから閉じ込め部材を完全に引き離す引き離し部材と；を
    備えた液体塞栓送込みシステム。
  2. 【請求項２】 閉じ込め部材は、液体塞栓組成物で充填されるフレキシブ
    ル袋である請求項１に記載の液体塞栓送込みシステム。
  3. 【請求項３】 フレキシブル袋は管腔の遠位出口全体にわたって位置し、
    フレキシブル袋のネックはカテーテル管腔の開口の回りのカテーテルの遠位端に
    接続され、引き離し機構によってカテーテルの遠位端からフレキシブル袋を引き
    離される請求項２に記載の液体塞栓送込みシステム。
  4. 【請求項４】 フレキシブル袋は溶剤が袋を通過することができる網材料
    から成り、網材料は凝固する液体塞栓組成物を含んでいる請求項２に記載の液体
    塞栓送込みシステム。
  5. 【請求項５】 フレキシブル袋はカテーテルの遠位端全体にわたって弾性
    バルーンとして形成されている請求項２に記載の液体塞栓送込みシステム。
  6. 【請求項６】 閉じ込め部材はカテーテルの遠位端から延びる巣状部材で
    あり、液体塞栓組成物が凝固する際に液体塞栓組成物を捕捉するように配置した
    請求項１に記載の液体塞栓送込みシステム。
  7. 【請求項７】 巣状部材は、カテーテルを介して送られるワイヤから成り
    、管腔の遠位端を出る際にコイルを形成する請求項６に記載の液体塞栓送込みシ
    ステム。
  8. 【請求項８】 巣状部材はワイヤブラシ状である請求項６に記載の液体塞
    栓送込みシステム。
  9. 【請求項９】 巣状部材は綿棒状である請求項６に記載の液体塞栓送込み
    システム。
  10. 【請求項１０】 巣状部材はスポンジ状である請求項６に記載の液体塞栓
    送込みシステム。
  11. 【請求項１１】 巣状部材はフレキシブル袋である請求項６に記載の液体
    塞栓送込みシステム。
  12. 【請求項１２】 巣状部材は、カテーテルを介して送られるワイヤから成
    り、管腔の遠位端を出る際にランダムに形成された巣を形成する請求項６に記載
    の液体塞栓送込みシステム。
  13. 【請求項１３】 引き離し機構は、閉じ込め部材をカテーテルから引き離
    すために、閉じ込め部材とカテーテルとの間の点に電荷を送り込む手段を含む請
    求項１に記載の液体塞栓送込みシステム。
  14. 【請求項１４】 引き離し機構は、化学剤に溶解する、閉じ込め部材とカ
    テーテルとの間の化学的引き離し部分を含む請求項１に記載の液体塞栓送込みシ
    ステム。
  15. 【請求項１５】 体内の塞栓サイトに液体塞栓組成物を閉じ込める方法で
    あって： カテーテルを用いて体内の塞栓サイトに液体塞栓組成物を送り込む段階と； 閉じ込め部材を用いて凝固の間に液体塞栓組成物を閉じ込める段階と； 凝固した塞栓組成物の塊からカテーテルを離すために、液体塞栓組成物の凝固
    の後にカテーテルから閉じ込め部材を引き離す段階と；を備えた方法。
  16. 【請求項１６】 液体塞栓組成物が、凝固中に、巣状部材に塞栓組成物を
    捕捉することによって閉じ込められる請求項１５に記載の方法。
  17. 【請求項１７】 液体塞栓組成物がフレキシブル袋で閉じ込められ、溶剤
    が液体塞栓組成物の凝固中に袋を介して放散していく請求項１５に記載の方法。
  18. 【請求項１８】 カテーテルの管腔から閉じ込め部材を移動することによ
    って、液体塞栓組成物を送り込む前に、閉じ込め部材を塞栓サイトに配置する請
    求項１５に記載の方法。
  19. 【請求項１９】 閉じ込め部材とカテーテルとが、導入カテーテルを介し
    て塞栓サイトに送り込まれる請求項１５に記載の方法。
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010067463A1 (ja) * 2008-12-10 2010-06-17 株式会社カルディオ 大動脈弁置換手術用の組織片捕捉具および大動脈弁置換手術における組織片捕捉方法
JP2011519300A (ja) * 2008-05-01 2011-07-07 アニュクローズ エルエルシー 動脈瘤閉塞装置
JP2012100833A (ja) * 2010-11-09 2012-05-31 Goodman Co Ltd 医療用器具
JP2014030721A (ja) * 2012-08-06 2014-02-20 Covidien Lp 塞栓組成物を送達するための装置および方法
WO2016153072A1 (ja) * 2015-03-26 2016-09-29 国立大学法人信州大学 血液凝固剤溶液、血液凝固剤溶液の製造方法、および液体の血液塞栓性タンパク質固有組成物ｅ２ｐの製造方法
WO2023042909A1 (ja) * 2021-09-17 2023-03-23 テルモ株式会社 カテーテルおよび塞栓物装填済みカテーテル

Families Citing this family (744)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030195607A1 (en) * 2002-03-18 2003-10-16 Trout Hugh H. Method and apparatus to attach an unsupported surgical component
US7569066B2 (en) 1997-07-10 2009-08-04 Boston Scientific Scimed, Inc. Methods and devices for the treatment of aneurysms
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US7637948B2 (en) 1997-10-10 2009-12-29 Senorx, Inc. Tissue marking implant
US6511468B1 (en) 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US20090216118A1 (en) 2007-07-26 2009-08-27 Senorx, Inc. Polysaccharide markers
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US6725083B1 (en) 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US7651505B2 (en) 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US6575991B1 (en) 1999-06-17 2003-06-10 Inrad, Inc. Apparatus for the percutaneous marking of a lesion
US8048104B2 (en) 2000-10-30 2011-11-01 Dendron Gmbh Device for the implantation of occlusion spirals
AU2002239290A1 (en) 2000-11-20 2002-06-03 Senorx, Inc. Tissue site markers for in vivo imaging
US6603994B2 (en) 2000-12-28 2003-08-05 Scimed Life Systems, Inc. Apparatus and method for internally inducing a magnetic field in an aneurysm to embolize aneurysm with magnetically-controllable substance
US6540657B2 (en) 2000-12-28 2003-04-01 Scimed Life Systems, Inc. Apparatus and method for internally inducing a magnetic field in an aneurysm to embolize aneurysm with magnetically-controllable substance
US6626819B2 (en) 2001-01-12 2003-09-30 Scimed Life Systems, Inc. Permanent magnetic and electromagnetic apparatus for embolizing an aneurysm with magnetically controllable embolic and method
EP1258230A3 (en) 2001-03-29 2003-12-10 CardioSafe Ltd Balloon catheter device
US6602269B2 (en) * 2001-03-30 2003-08-05 Scimed Life Systems Embolic devices capable of in-situ reinforcement
US6855153B2 (en) * 2001-05-01 2005-02-15 Vahid Saadat Embolic balloon
US20040225279A1 (en) * 2001-06-01 2004-11-11 Jean Raymond Detachable tip microcatheter for use of liquid embolic agents
US20030045859A1 (en) * 2001-06-11 2003-03-06 Larry Dominguez Delivery system using balloon catheter
US20030028209A1 (en) * 2001-07-31 2003-02-06 Clifford Teoh Expandable body cavity liner device
GB0121980D0 (en) 2001-09-11 2001-10-31 Cathnet Science Holding As Expandable stent
US20060292206A1 (en) 2001-11-26 2006-12-28 Kim Steven W Devices and methods for treatment of vascular aneurysms
US7147656B2 (en) * 2001-12-03 2006-12-12 Xtent, Inc. Apparatus and methods for delivery of braided prostheses
US7309350B2 (en) * 2001-12-03 2007-12-18 Xtent, Inc. Apparatus and methods for deployment of vascular prostheses
US7270668B2 (en) * 2001-12-03 2007-09-18 Xtent, Inc. Apparatus and methods for delivering coiled prostheses
US7892273B2 (en) * 2001-12-03 2011-02-22 Xtent, Inc. Custom length stent apparatus
US8080048B2 (en) 2001-12-03 2011-12-20 Xtent, Inc. Stent delivery for bifurcated vessels
US7137993B2 (en) * 2001-12-03 2006-11-21 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7294146B2 (en) 2001-12-03 2007-11-13 Xtent, Inc. Apparatus and methods for delivery of variable length stents
US20030135266A1 (en) * 2001-12-03 2003-07-17 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7182779B2 (en) * 2001-12-03 2007-02-27 Xtent, Inc. Apparatus and methods for positioning prostheses for deployment from a catheter
US20040186551A1 (en) * 2003-01-17 2004-09-23 Xtent, Inc. Multiple independent nested stent structures and methods for their preparation and deployment
US7351255B2 (en) * 2001-12-03 2008-04-01 Xtent, Inc. Stent delivery apparatus and method
US20040006302A1 (en) * 2002-01-25 2004-01-08 Hassan Chaouk Coaxial delivery device
US7695488B2 (en) * 2002-03-27 2010-04-13 Boston Scientific Scimed, Inc. Expandable body cavity liner device
US20030195553A1 (en) 2002-04-12 2003-10-16 Scimed Life Systems, Inc. System and method for retaining vaso-occlusive devices within an aneurysm
US20030204246A1 (en) * 2002-04-25 2003-10-30 Jack Chu Aneurysm treatment system and method
US7771387B2 (en) 2002-05-17 2010-08-10 Boston Scientific Scimed, Inc. Liquid embolic composition delivery devices and methods
US7338511B2 (en) * 2002-05-24 2008-03-04 Boston Scientific-Scimed, Inc. Solid embolic material with variable expansion
US7481821B2 (en) 2002-11-12 2009-01-27 Thomas J. Fogarty Embolization device and a method of using the same
US20060036158A1 (en) 2003-11-17 2006-02-16 Inrad, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US20040260382A1 (en) 2003-02-12 2004-12-23 Fogarty Thomas J. Intravascular implants and methods of using the same
US20070084897A1 (en) 2003-05-20 2007-04-19 Shelton Frederick E Iv Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism
US9060770B2 (en) 2003-05-20 2015-06-23 Ethicon Endo-Surgery, Inc. Robotically-driven surgical instrument with E-beam driver
US7877133B2 (en) 2003-05-23 2011-01-25 Senorx, Inc. Marker or filler forming fluid
US7241308B2 (en) * 2003-06-09 2007-07-10 Xtent, Inc. Stent deployment systems and methods
US20050015110A1 (en) 2003-07-18 2005-01-20 Fogarty Thomas J. Embolization device and a method of using the same
US7371228B2 (en) * 2003-09-19 2008-05-13 Medtronic Vascular, Inc. Delivery of therapeutics to treat aneurysms
US7553324B2 (en) * 2003-10-14 2009-06-30 Xtent, Inc. Fixed stent delivery devices and methods
US20050080475A1 (en) * 2003-10-14 2005-04-14 Xtent, Inc. A Delaware Corporation Stent delivery devices and methods
US7192440B2 (en) * 2003-10-15 2007-03-20 Xtent, Inc. Implantable stent delivery devices and methods
US20050090804A1 (en) * 2003-10-22 2005-04-28 Trivascular, Inc. Endoluminal prosthesis endoleak management
US20050273002A1 (en) 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
US7403966B2 (en) * 2003-12-08 2008-07-22 Freescale Semiconductor, Inc. Hardware for performing an arithmetic function
US20070156225A1 (en) * 2003-12-23 2007-07-05 Xtent, Inc. Automated control mechanisms and methods for custom length stent apparatus
US7326236B2 (en) 2003-12-23 2008-02-05 Xtent, Inc. Devices and methods for controlling and indicating the length of an interventional element
DE102004003265A1 (de) 2004-01-21 2005-08-11 Dendron Gmbh Vorrichtung zur Implantation von elektrisch isolierten Okklusionswendeln
US20050228433A1 (en) * 2004-03-16 2005-10-13 Weenna Bucay-Couto In situ implant and method of forming same
US7959634B2 (en) * 2004-03-29 2011-06-14 Soteira Inc. Orthopedic surgery access devices
US7323006B2 (en) * 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
US20050228477A1 (en) * 2004-04-09 2005-10-13 Xtent, Inc. Topographic coatings and coating methods for medical devices
ES2357243T3 (es) * 2004-05-21 2011-04-20 Micro Therapeutics, Inc. Espirales metálicas entrelazadas con polímeros o fibras biológicos o biodegradables o sintéticos para la embolización de una cavidad corporal.
US8267985B2 (en) 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US20050288766A1 (en) * 2004-06-28 2005-12-29 Xtent, Inc. Devices and methods for controlling expandable prostheses during deployment
US8317859B2 (en) * 2004-06-28 2012-11-27 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US11896225B2 (en) 2004-07-28 2024-02-13 Cilag Gmbh International Staple cartridge comprising a pan
US9072535B2 (en) 2011-05-27 2015-07-07 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with rotatable staple deployment arrangements
US8215531B2 (en) 2004-07-28 2012-07-10 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having a medical substance dispenser
US11998198B2 (en) 2004-07-28 2024-06-04 Cilag Gmbh International Surgical stapling instrument incorporating a two-piece E-beam firing mechanism
US7879064B2 (en) * 2004-09-22 2011-02-01 Micro Therapeutics, Inc. Medical implant
US8845676B2 (en) * 2004-09-22 2014-09-30 Micro Therapeutics Micro-spiral implantation device
US20060069424A1 (en) * 2004-09-27 2006-03-30 Xtent, Inc. Self-constrained segmented stents and methods for their deployment
US8066732B2 (en) * 2004-12-30 2011-11-29 Cook Incorporated Inverting occlusion devices, methods, and systems
WO2006082493A2 (en) * 2005-02-04 2006-08-10 Zuli Holdings, Ltd. Device and methods for non-surgical clipping of aneurysms
US7402168B2 (en) * 2005-04-11 2008-07-22 Xtent, Inc. Custom-length stent delivery system with independently operable expansion elements
US10357328B2 (en) 2005-04-20 2019-07-23 Bard Peripheral Vascular, Inc. and Bard Shannon Limited Marking device with retractable cannula
US8740934B2 (en) * 2005-04-22 2014-06-03 Rex Medical, L.P. Closure device for left atrial appendage
DE102005019782A1 (de) * 2005-04-28 2006-11-09 Dendron Gmbh Vorrichtung zur Implantation von Okklusionswendeln mit innenliegendem Sicherungsmittel
US20090081122A1 (en) * 2005-05-23 2009-03-26 Universite De Geneve Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
EP1883371B1 (en) 2005-05-25 2015-10-07 Covidien LP System and method for delivering and deploying and occluding device within a vessel
US8273101B2 (en) 2005-05-25 2012-09-25 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8157851B2 (en) * 2005-06-08 2012-04-17 Xtent, Inc. Apparatus and methods for deployment of multiple custom-length prostheses
US7938851B2 (en) * 2005-06-08 2011-05-10 Xtent, Inc. Devices and methods for operating and controlling interventional apparatus
US7669746B2 (en) 2005-08-31 2010-03-02 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US10159482B2 (en) 2005-08-31 2018-12-25 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US7934630B2 (en) 2005-08-31 2011-05-03 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US8317070B2 (en) 2005-08-31 2012-11-27 Ethicon Endo-Surgery, Inc. Surgical stapling devices that produce formed staples having different lengths
US9237891B2 (en) 2005-08-31 2016-01-19 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US8800838B2 (en) 2005-08-31 2014-08-12 Ethicon Endo-Surgery, Inc. Robotically-controlled cable-based surgical end effectors
FR2891464B1 (fr) * 2005-10-05 2008-07-18 Balt Extrusion Sa Catheter de securite pour injection de fluide notamment embolique
CA2562580C (en) 2005-10-07 2014-04-29 Inrad, Inc. Drug-eluting tissue marker
US20070102472A1 (en) * 2005-11-04 2007-05-10 Ethicon Endo-Surgery, Inc. Electrosurgical stapling instrument with disposable severing / stapling unit
US7328828B2 (en) * 2005-11-04 2008-02-12 Ethicon Endo-Surgery, Inc, Lockout mechanisms and surgical instruments including same
US7607557B2 (en) * 2005-11-04 2009-10-27 Ethicon Endo-Surgery, Inc. Surgical stapling instruments structured for pump-assisted delivery of medical agents
US20070106317A1 (en) 2005-11-09 2007-05-10 Shelton Frederick E Iv Hydraulically and electrically actuated articulation joints for surgical instruments
US7670334B2 (en) * 2006-01-10 2010-03-02 Ethicon Endo-Surgery, Inc. Surgical instrument having an articulating end effector
US20070179587A1 (en) * 2006-01-30 2007-08-02 Xtent, Inc. Apparatus and methods for deployment of custom-length prostheses
US20120292367A1 (en) 2006-01-31 2012-11-22 Ethicon Endo-Surgery, Inc. Robotically-controlled end effector
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US8186555B2 (en) 2006-01-31 2012-05-29 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with mechanical closure system
US8763879B2 (en) * 2006-01-31 2014-07-01 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of surgical instrument
US7464846B2 (en) * 2006-01-31 2008-12-16 Ethicon Endo-Surgery, Inc. Surgical instrument having a removable battery
US7770775B2 (en) 2006-01-31 2010-08-10 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with adaptive user feedback
US9861359B2 (en) 2006-01-31 2018-01-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US20110024477A1 (en) 2009-02-06 2011-02-03 Hall Steven G Driven Surgical Stapler Improvements
US7845537B2 (en) 2006-01-31 2010-12-07 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
US8708213B2 (en) 2006-01-31 2014-04-29 Ethicon Endo-Surgery, Inc. Surgical instrument having a feedback system
US7575144B2 (en) 2006-01-31 2009-08-18 Ethicon Endo-Surgery, Inc. Surgical fastener and cutter with single cable actuator
US8161977B2 (en) 2006-01-31 2012-04-24 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US7416101B2 (en) * 2006-01-31 2008-08-26 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with loading force feedback
US7753904B2 (en) 2006-01-31 2010-07-13 Ethicon Endo-Surgery, Inc. Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US8820603B2 (en) 2006-01-31 2014-09-02 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US20110290856A1 (en) 2006-01-31 2011-12-01 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical instrument with force-feedback capabilities
US7766210B2 (en) * 2006-01-31 2010-08-03 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with user feedback system
US20110006101A1 (en) * 2009-02-06 2011-01-13 EthiconEndo-Surgery, Inc. Motor driven surgical fastener device with cutting member lockout arrangements
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US7568603B2 (en) * 2006-01-31 2009-08-04 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with articulatable end effector
US7464849B2 (en) * 2006-01-31 2008-12-16 Ethicon Endo-Surgery, Inc. Electro-mechanical surgical instrument with closure system and anvil alignment components
US7422139B2 (en) * 2006-01-31 2008-09-09 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting fastening instrument with tactile position feedback
WO2007109621A2 (en) 2006-03-20 2007-09-27 Xtent, Inc. Apparatus and methods for deployment of linked prosthetic segments
US8721630B2 (en) 2006-03-23 2014-05-13 Ethicon Endo-Surgery, Inc. Methods and devices for controlling articulation
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
US20070225562A1 (en) 2006-03-23 2007-09-27 Ethicon Endo-Surgery, Inc. Articulating endoscopic accessory channel
US20070237720A1 (en) * 2006-04-06 2007-10-11 Orlando Padilla Embolic prosthesis for treatment of vascular aneurysm
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
US8864790B2 (en) 2006-04-17 2014-10-21 Covidien Lp System and method for mechanically positioning intravascular implants
US20070281117A1 (en) * 2006-06-02 2007-12-06 Xtent, Inc. Use of plasma in formation of biodegradable stent coating
JP2010500917A (ja) 2006-06-15 2010-01-14 マイクロベンション， インコーポレイテッド 膨張性ポリマーで構成される塞栓形成デバイス
US8322455B2 (en) 2006-06-27 2012-12-04 Ethicon Endo-Surgery, Inc. Manually driven surgical cutting and fastening instrument
CA2660851A1 (en) * 2006-08-17 2008-02-21 Nfocus Neuromedical, Inc. Isolation devices for the treatment of aneurysms
US10130359B2 (en) 2006-09-29 2018-11-20 Ethicon Llc Method for forming a staple
US8360297B2 (en) 2006-09-29 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical cutting and stapling instrument with self adjusting anvil
US10568652B2 (en) 2006-09-29 2020-02-25 Ethicon Llc Surgical staples having attached drivers of different heights and stapling instruments for deploying the same
US11980366B2 (en) 2006-10-03 2024-05-14 Cilag Gmbh International Surgical instrument
ES2443526T3 (es) 2006-10-23 2014-02-19 C.R. Bard, Inc. Marcador mamario
US20080269774A1 (en) * 2006-10-26 2008-10-30 Chestnut Medical Technologies, Inc. Intracorporeal Grasping Device
EP3542748B1 (en) 2006-12-12 2023-08-16 C. R. Bard, Inc. Multiple imaging mode tissue marker
WO2008076330A1 (en) * 2006-12-15 2008-06-26 Soteira, Inc. Drills and methods for vertebrostenting
US9480485B2 (en) 2006-12-15 2016-11-01 Globus Medical, Inc. Devices and methods for vertebrostenting
WO2008076973A2 (en) 2006-12-18 2008-06-26 C.R.Bard Inc. Biopsy marker with in situ-generated imaging properties
US8652120B2 (en) 2007-01-10 2014-02-18 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US8459520B2 (en) 2007-01-10 2013-06-11 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and remote sensor
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US8840603B2 (en) 2007-01-10 2014-09-23 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US8684253B2 (en) 2007-01-10 2014-04-01 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US20080169332A1 (en) 2007-01-11 2008-07-17 Shelton Frederick E Surgical stapling device with a curved cutting member
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US20080199510A1 (en) * 2007-02-20 2008-08-21 Xtent, Inc. Thermo-mechanically controlled implants and methods of use
WO2008109228A2 (en) * 2007-03-05 2008-09-12 Boston Scientific Limited Deploying embolic coils
KR20100015520A (ko) 2007-03-13 2010-02-12 마이크로 테라퓨틱스 인코포레이티드 코일과 펴짐방지 부재를 포함하는 임플란트
KR20100015521A (ko) 2007-03-13 2010-02-12 마이크로 테라퓨틱스 인코포레이티드 임플란트, 맨드릴, 및 임플란트 형성방법
US20090001130A1 (en) * 2007-03-15 2009-01-01 Hess Christopher J Surgical procedure using a cutting and stapling instrument having releasable staple-forming pockets
US8486132B2 (en) 2007-03-22 2013-07-16 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US8893946B2 (en) 2007-03-28 2014-11-25 Ethicon Endo-Surgery, Inc. Laparoscopic tissue thickness and clamp load measuring devices
US11672531B2 (en) 2007-06-04 2023-06-13 Cilag Gmbh International Rotary drive systems for surgical instruments
US7905380B2 (en) * 2007-06-04 2011-03-15 Ethicon Endo-Surgery, Inc. Surgical instrument having a multiple rate directional switching mechanism
US8931682B2 (en) 2007-06-04 2015-01-13 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
US7832408B2 (en) 2007-06-04 2010-11-16 Ethicon Endo-Surgery, Inc. Surgical instrument having a directional switching mechanism
US8534528B2 (en) * 2007-06-04 2013-09-17 Ethicon Endo-Surgery, Inc. Surgical instrument having a multiple rate directional switching mechanism
WO2008151204A1 (en) 2007-06-04 2008-12-11 Sequent Medical Inc. Methods and devices for treatment of vascular defects
US7753245B2 (en) 2007-06-22 2010-07-13 Ethicon Endo-Surgery, Inc. Surgical stapling instruments
US20080319522A1 (en) * 2007-06-22 2008-12-25 Von Lehe Cathleen Aneurysm filler detacher
US8308040B2 (en) 2007-06-22 2012-11-13 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with an articulatable end effector
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US20090076584A1 (en) * 2007-09-19 2009-03-19 Xtent, Inc. Apparatus and methods for deployment of multiple custom-length prostheses
BRPI0821070B1 (pt) 2007-12-21 2018-10-23 Microvention Inc dispositivo para implantação e método para a preparação de um filamento de hidrogel para implantação em um animal
WO2009099767A2 (en) 2008-01-31 2009-08-13 C.R. Bard, Inc. Biopsy tissue marker
US8561870B2 (en) 2008-02-13 2013-10-22 Ethicon Endo-Surgery, Inc. Surgical stapling instrument
US7905381B2 (en) 2008-09-19 2011-03-15 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with cutting member arrangement
US8622274B2 (en) 2008-02-14 2014-01-07 Ethicon Endo-Surgery, Inc. Motorized cutting and fastening instrument having control circuit for optimizing battery usage
US7866527B2 (en) 2008-02-14 2011-01-11 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US8584919B2 (en) 2008-02-14 2013-11-19 Ethicon Endo-Sugery, Inc. Surgical stapling apparatus with load-sensitive firing mechanism
US8758391B2 (en) 2008-02-14 2014-06-24 Ethicon Endo-Surgery, Inc. Interchangeable tools for surgical instruments
US8459525B2 (en) 2008-02-14 2013-06-11 Ethicon Endo-Sugery, Inc. Motorized surgical cutting and fastening instrument having a magnetic drive train torque limiting device
BRPI0901282A2 (pt) 2008-02-14 2009-11-17 Ethicon Endo Surgery Inc instrumento cirúrgico de corte e fixação dotado de eletrodos de rf
US8573465B2 (en) 2008-02-14 2013-11-05 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical end effector system with rotary actuated closure systems
US8636736B2 (en) 2008-02-14 2014-01-28 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument
US8657174B2 (en) 2008-02-14 2014-02-25 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument having handle based power source
US8752749B2 (en) 2008-02-14 2014-06-17 Ethicon Endo-Surgery, Inc. Robotically-controlled disposable motor-driven loading unit
US7819298B2 (en) * 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
US9179912B2 (en) 2008-02-14 2015-11-10 Ethicon Endo-Surgery, Inc. Robotically-controlled motorized surgical cutting and fastening instrument
US7793812B2 (en) * 2008-02-14 2010-09-14 Ethicon Endo-Surgery, Inc. Disposable motor-driven loading unit for use with a surgical cutting and stapling apparatus
US11986183B2 (en) 2008-02-14 2024-05-21 Cilag Gmbh International Surgical cutting and fastening instrument comprising a plurality of sensors to measure an electrical parameter
US11272927B2 (en) 2008-02-15 2022-03-15 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US10390823B2 (en) 2008-02-15 2019-08-27 Ethicon Llc End effector comprising an adjunct
US9101503B2 (en) * 2008-03-06 2015-08-11 J.W. Medical Systems Ltd. Apparatus having variable strut length and methods of use
DK2265193T3 (da) * 2008-04-21 2012-01-23 Nfocus Neuromedical Inc Emboliske indretninger med flettet kugle og leveringssystemer
WO2009132141A1 (en) * 2008-04-22 2009-10-29 Coherex Medical, Inc. Device, system and method for aneurysm embolization
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
US11471163B2 (en) 2008-05-01 2022-10-18 Aneuclose Llc Intrasaccular aneurysm occlusion device with net or mesh expanded by string-of-pearls embolies
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
US11484322B2 (en) 2018-01-03 2022-11-01 Aneuclose Llc Aneurysm neck bridge with a closeable opening or lumen through which embolic material is inserted into the aneurysm sac
US11464518B2 (en) 2008-05-01 2022-10-11 Aneuclose Llc Proximal concave neck bridge with central lumen and distal net for occluding cerebral aneurysms
CN106974691A (zh) 2008-05-02 2017-07-25 斯昆特医疗公司 用于治疗血管缺损的丝状装置
US9675482B2 (en) * 2008-05-13 2017-06-13 Covidien Lp Braid implant delivery systems
WO2009155319A1 (en) * 2008-06-17 2009-12-23 Soteira, Inc. Devices and methods for fracture reduction
EP2341843A1 (en) * 2008-07-22 2011-07-13 Micro Therapeutics, Inc. Vascular remodeling device
AU2009282868B2 (en) 2008-08-19 2013-09-05 Covidien Lp Detachable tip microcatheter
PL3476312T3 (pl) 2008-09-19 2024-03-11 Ethicon Llc Stapler chirurgiczny z urządzeniem do dopasowania wysokości zszywek
US8210411B2 (en) 2008-09-23 2012-07-03 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
US9386983B2 (en) 2008-09-23 2016-07-12 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument
US9005230B2 (en) 2008-09-23 2015-04-14 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US9050083B2 (en) 2008-09-23 2015-06-09 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US11298252B2 (en) 2008-09-25 2022-04-12 Advanced Bifurcation Systems Inc. Stent alignment during treatment of a bifurcation
US8821562B2 (en) 2008-09-25 2014-09-02 Advanced Bifurcation Systems, Inc. Partially crimped stent
US8769796B2 (en) 2008-09-25 2014-07-08 Advanced Bifurcation Systems, Inc. Selective stent crimping
EP4147681A1 (en) 2008-09-25 2023-03-15 Advanced Bifurcation Systems Inc. Partially crimped stent
US12076258B2 (en) 2008-09-25 2024-09-03 Advanced Bifurcation Systems Inc. Selective stent crimping
US12324756B2 (en) 2008-09-25 2025-06-10 Advanced Bifurcation Systems Inc. System and methods for treating a bifurcation
US8608045B2 (en) 2008-10-10 2013-12-17 Ethicon Endo-Sugery, Inc. Powered surgical cutting and stapling apparatus with manually retractable firing system
BRPI0823399B8 (pt) 2008-12-30 2021-06-22 Bard Inc C R dispositivo de liberação de marcador para posicionamento de marcador de tecido
US8397971B2 (en) 2009-02-05 2013-03-19 Ethicon Endo-Surgery, Inc. Sterilizable surgical instrument
US8517239B2 (en) 2009-02-05 2013-08-27 Ethicon Endo-Surgery, Inc. Surgical stapling instrument comprising a magnetic element driver
US8414577B2 (en) * 2009-02-05 2013-04-09 Ethicon Endo-Surgery, Inc. Surgical instruments and components for use in sterile environments
EP2393430A1 (en) 2009-02-06 2011-12-14 Ethicon Endo-Surgery, Inc. Driven surgical stapler improvements
US8444036B2 (en) 2009-02-06 2013-05-21 Ethicon Endo-Surgery, Inc. Motor driven surgical fastener device with mechanisms for adjusting a tissue gap within the end effector
EP2424775B1 (en) 2009-04-30 2016-02-10 Technip France Spar mooring line sharing method and system
WO2011053555A1 (en) 2009-10-26 2011-05-05 Microvention, Inc. Embolization device constructed from expansile polymer
WO2011057002A2 (en) * 2009-11-05 2011-05-12 Sequent Medical Inc. Multiple layer filamentary devices or treatment of vascular defects
CA2779483C (en) * 2009-11-09 2018-03-13 Nfocus Neuromedical, Inc. Braid ball embolic device features
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
US8851354B2 (en) 2009-12-24 2014-10-07 Ethicon Endo-Surgery, Inc. Surgical cutting instrument that analyzes tissue thickness
US8220688B2 (en) 2009-12-24 2012-07-17 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument with electric actuator directional control assembly
JP4499831B1 (ja) * 2010-01-22 2010-07-07 規方 田熊 動脈瘤塞栓具
EP2528541B1 (en) * 2010-01-28 2016-05-18 Covidien LP Vascular remodeling device
CN102740799A (zh) * 2010-01-28 2012-10-17 泰科保健集团有限合伙公司 脉管重塑装置
CA2794064A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc. Methods and systems for treating a bifurcation with provisional side branch stenting
WO2011119884A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc System and methods for treating a bifurcation
EP2549951B1 (en) 2010-03-24 2017-05-10 Advanced Bifurcation Systems, Inc. Stent alignment during treatment of a bifurcation
US8783543B2 (en) 2010-07-30 2014-07-22 Ethicon Endo-Surgery, Inc. Tissue acquisition arrangements and methods for surgical stapling devices
US8998947B2 (en) 2010-09-10 2015-04-07 Medina Medical, Inc. Devices and methods for the treatment of vascular defects
JP6087281B2 (ja) 2010-09-10 2017-03-01 メディナ メディカル，インコーポレイテッド 血管異常を治療するデバイス及び方法
US9877720B2 (en) 2010-09-24 2018-01-30 Ethicon Llc Control features for articulating surgical device
US11812965B2 (en) 2010-09-30 2023-11-14 Cilag Gmbh International Layer of material for a surgical end effector
US8893949B2 (en) 2010-09-30 2014-11-25 Ethicon Endo-Surgery, Inc. Surgical stapler with floating anvil
US8740038B2 (en) 2010-09-30 2014-06-03 Ethicon Endo-Surgery, Inc. Staple cartridge comprising a releasable portion
US9364233B2 (en) 2010-09-30 2016-06-14 Ethicon Endo-Surgery, Llc Tissue thickness compensators for circular surgical staplers
US9232941B2 (en) 2010-09-30 2016-01-12 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a reservoir
US9216019B2 (en) 2011-09-23 2015-12-22 Ethicon Endo-Surgery, Inc. Surgical stapler with stationary staple drivers
US9301752B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising a plurality of capsules
US9220501B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensators
US9307989B2 (en) 2012-03-28 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorportating a hydrophobic agent
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US9351730B2 (en) 2011-04-29 2016-05-31 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising channels
US9314246B2 (en) 2010-09-30 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US10123798B2 (en) 2010-09-30 2018-11-13 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US9204880B2 (en) 2012-03-28 2015-12-08 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising capsules defining a low pressure environment
US9788834B2 (en) 2010-09-30 2017-10-17 Ethicon Llc Layer comprising deployable attachment members
EP2621356B1 (en) 2010-09-30 2018-03-07 Ethicon LLC Fastener system comprising a retention matrix and an alignment matrix
US9332974B2 (en) 2010-09-30 2016-05-10 Ethicon Endo-Surgery, Llc Layered tissue thickness compensator
US12213666B2 (en) 2010-09-30 2025-02-04 Cilag Gmbh International Tissue thickness compensator comprising layers
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US11849952B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US9386988B2 (en) 2010-09-30 2016-07-12 Ethicon End-Surgery, LLC Retainer assembly including a tissue thickness compensator
US8695866B2 (en) 2010-10-01 2014-04-15 Ethicon Endo-Surgery, Inc. Surgical instrument having a power control circuit
EP3777780B1 (en) 2011-02-08 2024-04-24 Advanced Bifurcation Systems Inc. System for treating a bifurcation with a fully crimped stent
CA2826760A1 (en) 2011-02-08 2012-08-16 Advanced Bifurcation Systems, Inc. Multi-stent and multi-balloon apparatus for treating bifurcations and methods of use
CN103442653B (zh) 2011-02-11 2016-06-01 柯惠有限合伙公司 两阶段展开动脉瘤栓塞装置
US20120245674A1 (en) 2011-03-25 2012-09-27 Tyco Healthcare Group Lp Vascular remodeling device
US9456823B2 (en) 2011-04-18 2016-10-04 Terumo Corporation Embolic devices
BR112013027794B1 (pt) 2011-04-29 2020-12-15 Ethicon Endo-Surgery, Inc Conjunto de cartucho de grampos
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
CN103732181B (zh) 2011-08-12 2016-05-04 W.L.戈尔及同仁股份有限公司 用于近似具有分支的脉管系统的横截面轮廓的装置
US20130204234A1 (en) * 2011-08-12 2013-08-08 Edward H. Cully Systems for the reduction of leakage around medical devices at a treatment site
US9050084B2 (en) 2011-09-23 2015-06-09 Ethicon Endo-Surgery, Inc. Staple cartridge including collapsible deck arrangement
WO2013049448A1 (en) 2011-09-29 2013-04-04 Covidien Lp Vascular remodeling device
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US20150141900A1 (en) * 2011-12-01 2015-05-21 The Johns Hopkins University Method and Device for Targeted Delivery of Fluid Therapeutics
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US9044230B2 (en) 2012-02-13 2015-06-02 Ethicon Endo-Surgery, Inc. Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
BR112014024194B1 (pt) 2012-03-28 2022-03-03 Ethicon Endo-Surgery, Inc Conjunto de cartucho de grampos para um grampeador cirúrgico
US9198662B2 (en) 2012-03-28 2015-12-01 Ethicon Endo-Surgery, Inc. Tissue thickness compensator having improved visibility
JP6305979B2 (ja) 2012-03-28 2018-04-04 エシコン・エンド−サージェリィ・インコーポレイテッドＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ，Ｉｎｃ． 複数の層を含む組織厚さコンペンセーター
CN104334098B (zh) 2012-03-28 2017-03-22 伊西康内外科公司 包括限定低压强环境的胶囊剂的组织厚度补偿件
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
EP3984556B8 (en) 2012-06-14 2025-07-09 Microvention, Inc. Polymeric treatment compositions
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
US10124087B2 (en) 2012-06-19 2018-11-13 Covidien Lp Detachable coupling for catheter
BR112014032776B1 (pt) 2012-06-28 2021-09-08 Ethicon Endo-Surgery, Inc Sistema de instrumento cirúrgico e kit cirúrgico para uso com um sistema de instrumento cirúrgico
BR112014032740A2 (pt) 2012-06-28 2020-02-27 Ethicon Endo Surgery Inc bloqueio de cartucho de clipes vazio
US9101385B2 (en) 2012-06-28 2015-08-11 Ethicon Endo-Surgery, Inc. Electrode connections for rotary driven surgical tools
US20140001231A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Firing system lockout arrangements for surgical instruments
US9226751B2 (en) 2012-06-28 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical instrument system including replaceable end effectors
US9125662B2 (en) 2012-06-28 2015-09-08 Ethicon Endo-Surgery, Inc. Multi-axis articulating and rotating surgical tools
US8747238B2 (en) 2012-06-28 2014-06-10 Ethicon Endo-Surgery, Inc. Rotary drive shaft assemblies for surgical instruments with articulatable end effectors
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US9649111B2 (en) 2012-06-28 2017-05-16 Ethicon Endo-Surgery, Llc Replaceable clip cartridge for a clip applier
US9204879B2 (en) 2012-06-28 2015-12-08 Ethicon Endo-Surgery, Inc. Flexible drive member
US9119657B2 (en) 2012-06-28 2015-09-01 Ethicon Endo-Surgery, Inc. Rotary actuatable closure arrangement for surgical end effector
US12383267B2 (en) 2012-06-28 2025-08-12 Cilag Gmbh International Robotically powered surgical device with manually-actuatable reversing system
US9072536B2 (en) 2012-06-28 2015-07-07 Ethicon Endo-Surgery, Inc. Differential locking arrangements for rotary powered surgical instruments
US9028494B2 (en) 2012-06-28 2015-05-12 Ethicon Endo-Surgery, Inc. Interchangeable end effector coupling arrangement
US9561038B2 (en) 2012-06-28 2017-02-07 Ethicon Endo-Surgery, Llc Interchangeable clip applier
US11202631B2 (en) 2012-06-28 2021-12-21 Cilag Gmbh International Stapling assembly comprising a firing lockout
US9155647B2 (en) 2012-07-18 2015-10-13 Covidien Lp Methods and apparatus for luminal stenting
US9326774B2 (en) 2012-08-03 2016-05-03 Covidien Lp Device for implantation of medical devices
CN104717983B (zh) 2012-10-15 2018-09-18 微仙美国有限公司 聚合治疗组合物
US9314248B2 (en) 2012-11-06 2016-04-19 Covidien Lp Multi-pivot thrombectomy device
KR20150084959A (ko) 2012-11-13 2015-07-22 코비디엔 엘피 폐색 장치
US9623178B2 (en) * 2013-01-10 2017-04-18 The Cleveland Clinic Foundation Deployable joint infection treatment system
US10342546B2 (en) * 2013-01-14 2019-07-09 Microvention, Inc. Occlusive device
US9295571B2 (en) 2013-01-17 2016-03-29 Covidien Lp Methods and apparatus for luminal stenting
US20140214071A1 (en) * 2013-01-28 2014-07-31 Neurodynamics, Llc. Embolic coil delivery system and method of using same
US9386984B2 (en) 2013-02-08 2016-07-12 Ethicon Endo-Surgery, Llc Staple cartridge comprising a releasable cover
US10092292B2 (en) 2013-02-28 2018-10-09 Ethicon Llc Staple forming features for surgical stapling instrument
US9782169B2 (en) 2013-03-01 2017-10-10 Ethicon Llc Rotary powered articulation joints for surgical instruments
MX364729B (es) 2013-03-01 2019-05-06 Ethicon Endo Surgery Inc Instrumento quirúrgico con una parada suave.
MX368026B (es) 2013-03-01 2019-09-12 Ethicon Endo Surgery Inc Instrumento quirúrgico articulable con vías conductoras para la comunicación de la señal.
US9345481B2 (en) 2013-03-13 2016-05-24 Ethicon Endo-Surgery, Llc Staple cartridge tissue thickness sensor system
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
US9463105B2 (en) 2013-03-14 2016-10-11 Covidien Lp Methods and apparatus for luminal stenting
US9351727B2 (en) 2013-03-14 2016-05-31 Ethicon Endo-Surgery, Llc Drive train control arrangements for modular surgical instruments
CN105142545B (zh) 2013-03-15 2018-04-06 柯惠有限合伙公司 闭塞装置
US10660645B2 (en) 2013-03-15 2020-05-26 Embo Medical Limited Embolization systems
CN105705100A (zh) * 2013-03-15 2016-06-22 恩波医疗有限公司 栓塞系统
US10675039B2 (en) 2013-03-15 2020-06-09 Embo Medical Limited Embolisation systems
US9332984B2 (en) 2013-03-27 2016-05-10 Ethicon Endo-Surgery, Llc Fastener cartridge assemblies
US9572577B2 (en) 2013-03-27 2017-02-21 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a tissue thickness compensator including openings therein
US9795384B2 (en) 2013-03-27 2017-10-24 Ethicon Llc Fastener cartridge comprising a tissue thickness compensator and a gap setting element
BR112015026109B1 (pt) 2013-04-16 2022-02-22 Ethicon Endo-Surgery, Inc Instrumento cirúrgico
US9826976B2 (en) 2013-04-16 2017-11-28 Ethicon Llc Motor driven surgical instruments with lockable dual drive shafts
US9574644B2 (en) 2013-05-30 2017-02-21 Ethicon Endo-Surgery, Llc Power module for use with a surgical instrument
US9078658B2 (en) 2013-08-16 2015-07-14 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US9955976B2 (en) 2013-08-16 2018-05-01 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
MX369362B (es) 2013-08-23 2019-11-06 Ethicon Endo Surgery Llc Dispositivos de retraccion de miembros de disparo para instrumentos quirurgicos electricos.
US9987006B2 (en) 2013-08-23 2018-06-05 Ethicon Llc Shroud retention arrangement for sterilizable surgical instruments
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
JP6338670B2 (ja) 2013-12-20 2018-06-06 マイクロベンション インコーポレイテッドＭｉｃｒｏｖｅｎｔｉｏｎ， Ｉｎｃ． カテーテルシステム
CN106456182B (zh) 2013-12-20 2021-04-09 泰尔茂株式会社 血管闭塞装置
US20150173756A1 (en) 2013-12-23 2015-06-25 Ethicon Endo-Surgery, Inc. Surgical cutting and stapling methods
US9724092B2 (en) 2013-12-23 2017-08-08 Ethicon Llc Modular surgical instruments
US9839428B2 (en) 2013-12-23 2017-12-12 Ethicon Llc Surgical cutting and stapling instruments with independent jaw control features
US9585662B2 (en) 2013-12-23 2017-03-07 Ethicon Endo-Surgery, Llc Fastener cartridge comprising an extendable firing member
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
BR112016019387B1 (pt) 2014-02-24 2022-11-29 Ethicon Endo-Surgery, Llc Sistema de instrumento cirúrgico e cartucho de prendedores para uso com um instrumento cirúrgico de fixação
US9757124B2 (en) 2014-02-24 2017-09-12 Ethicon Llc Implantable layer assemblies
US9826977B2 (en) 2014-03-26 2017-11-28 Ethicon Llc Sterilization verification circuit
US9913642B2 (en) 2014-03-26 2018-03-13 Ethicon Llc Surgical instrument comprising a sensor system
US12232723B2 (en) 2014-03-26 2025-02-25 Cilag Gmbh International Systems and methods for controlling a segmented circuit
US9750499B2 (en) 2014-03-26 2017-09-05 Ethicon Llc Surgical stapling instrument system
US20150272557A1 (en) 2014-03-26 2015-10-01 Ethicon Endo-Surgery, Inc. Modular surgical instrument system
BR112016021943B1 (pt) 2014-03-26 2022-06-14 Ethicon Endo-Surgery, Llc Instrumento cirúrgico para uso por um operador em um procedimento cirúrgico
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
US9629635B2 (en) 2014-04-14 2017-04-25 Sequent Medical, Inc. Devices for therapeutic vascular procedures
CN106456158B (zh) 2014-04-16 2019-02-05 伊西康内外科有限责任公司 包括非一致紧固件的紧固件仓
CN106456176B (zh) 2014-04-16 2019-06-28 伊西康内外科有限责任公司 包括具有不同构型的延伸部的紧固件仓
US10542988B2 (en) 2014-04-16 2020-01-28 Ethicon Llc End effector comprising an anvil including projections extending therefrom
CN106456159B (zh) 2014-04-16 2019-03-08 伊西康内外科有限责任公司 紧固件仓组件和钉保持器盖布置结构
US20150297222A1 (en) 2014-04-16 2015-10-22 Ethicon Endo-Surgery, Inc. Fastener cartridges including extensions having different configurations
US10426476B2 (en) 2014-09-26 2019-10-01 Ethicon Llc Circular fastener cartridges for applying radially expandable fastener lines
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
WO2015167752A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers including active agents
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
US10045781B2 (en) 2014-06-13 2018-08-14 Ethicon Llc Closure lockout systems for surgical instruments
WO2016014341A2 (en) * 2014-07-23 2016-01-28 Boston Scientific Scimed, Inc. Endoscopic closure device using sealants
US10575839B2 (en) * 2014-07-29 2020-03-03 University Of Kansas Solenoid occlusion device
US9808256B2 (en) 2014-08-08 2017-11-07 Covidien Lp Electrolytic detachment elements for implant delivery systems
US9814466B2 (en) 2014-08-08 2017-11-14 Covidien Lp Electrolytic and mechanical detachment for implant delivery systems
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US10016199B2 (en) 2014-09-05 2018-07-10 Ethicon Llc Polarity of hall magnet to identify cartridge type
BR112017004361B1 (pt) 2014-09-05 2023-04-11 Ethicon Llc Sistema eletrônico para um instrumento cirúrgico
US10105142B2 (en) 2014-09-18 2018-10-23 Ethicon Llc Surgical stapler with plurality of cutting elements
JP6648119B2 (ja) 2014-09-26 2020-02-14 エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ 外科ステープル留めバットレス及び付属物材料
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
US10076325B2 (en) 2014-10-13 2018-09-18 Ethicon Llc Surgical stapling apparatus comprising a tissue stop
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US10517594B2 (en) 2014-10-29 2019-12-31 Ethicon Llc Cartridge assemblies for surgical staplers
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
BR112017012996B1 (pt) 2014-12-18 2022-11-08 Ethicon Llc Instrumento cirúrgico com uma bigorna que é seletivamente móvel sobre um eixo geométrico imóvel distinto em relação a um cartucho de grampos
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10004501B2 (en) 2014-12-18 2018-06-26 Ethicon Llc Surgical instruments with improved closure arrangements
US10117649B2 (en) 2014-12-18 2018-11-06 Ethicon Llc Surgical instrument assembly comprising a lockable articulation system
US10188385B2 (en) 2014-12-18 2019-01-29 Ethicon Llc Surgical instrument system comprising lockable systems
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US10180463B2 (en) 2015-02-27 2019-01-15 Ethicon Llc Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band
US10226250B2 (en) 2015-02-27 2019-03-12 Ethicon Llc Modular stapling assembly
US10182816B2 (en) 2015-02-27 2019-01-22 Ethicon Llc Charging system that enables emergency resolutions for charging a battery
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US10548504B2 (en) 2015-03-06 2020-02-04 Ethicon Llc Overlaid multi sensor radio frequency (RF) electrode system to measure tissue compression
US9808246B2 (en) 2015-03-06 2017-11-07 Ethicon Endo-Surgery, Llc Method of operating a powered surgical instrument
US9901342B2 (en) 2015-03-06 2018-02-27 Ethicon Endo-Surgery, Llc Signal and power communication system positioned on a rotatable shaft
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US9895148B2 (en) 2015-03-06 2018-02-20 Ethicon Endo-Surgery, Llc Monitoring speed control and precision incrementing of motor for powered surgical instruments
US9375333B1 (en) 2015-03-06 2016-06-28 Covidien Lp Implantable device detachment systems and associated devices and methods
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
JP2020121162A (ja) 2015-03-06 2020-08-13 エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ 測定の安定性要素、クリープ要素、及び粘弾性要素を決定するためのセンサデータの時間依存性評価
US9924961B2 (en) 2015-03-06 2018-03-27 Ethicon Endo-Surgery, Llc Interactive feedback system for powered surgical instruments
US10441279B2 (en) 2015-03-06 2019-10-15 Ethicon Llc Multiple level thresholds to modify operation of powered surgical instruments
US10045776B2 (en) 2015-03-06 2018-08-14 Ethicon Llc Control techniques and sub-processor contained within modular shaft with select control processing from handle
US10213201B2 (en) 2015-03-31 2019-02-26 Ethicon Llc Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw
US10265078B2 (en) 2015-04-01 2019-04-23 Boston Scientific Scimed, Inc. Systems and methods for delivery of gel embolics
US9717503B2 (en) 2015-05-11 2017-08-01 Covidien Lp Electrolytic detachment for implant delivery systems
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
US10052102B2 (en) 2015-06-18 2018-08-21 Ethicon Llc Surgical end effectors with dual cam actuated jaw closing features
US11058425B2 (en) 2015-08-17 2021-07-13 Ethicon Llc Implantable layers for a surgical instrument
US10098642B2 (en) 2015-08-26 2018-10-16 Ethicon Llc Surgical staples comprising features for improved fastening of tissue
RU2725747C2 (ru) 2015-08-26 2020-07-03 ЭТИКОН ЭлЭлСи Узел кассеты со скобами, содержащий различные зазоры для сжатия ткани и зазоры для формирования скоб
CN108348233B (zh) 2015-08-26 2021-05-07 伊西康有限责任公司 用于允许改变钉特性并实现轻松仓加载的外科钉条
MX2022009705A (es) 2015-08-26 2022-11-07 Ethicon Llc Metodo para formar una grapa contra un yunque de un instrumento de engrapado quirurgico.
US10238390B2 (en) 2015-09-02 2019-03-26 Ethicon Llc Surgical staple cartridges with driver arrangements for establishing herringbone staple patterns
MX2022006192A (es) 2015-09-02 2022-06-16 Ethicon Llc Configuraciones de grapas quirurgicas con superficies de leva situadas entre porciones que soportan grapas quirurgicas.
US10085751B2 (en) 2015-09-23 2018-10-02 Ethicon Llc Surgical stapler having temperature-based motor control
US10478194B2 (en) 2015-09-23 2019-11-19 Covidien Lp Occlusive devices
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US10076326B2 (en) 2015-09-23 2018-09-18 Ethicon Llc Surgical stapler having current mirror-based motor control
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US10363036B2 (en) 2015-09-23 2019-07-30 Ethicon Llc Surgical stapler having force-based motor control
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US10433846B2 (en) 2015-09-30 2019-10-08 Ethicon Llc Compressible adjunct with crossing spacer fibers
US11890015B2 (en) 2015-09-30 2024-02-06 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10478188B2 (en) 2015-09-30 2019-11-19 Ethicon Llc Implantable layer comprising a constricted configuration
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
CN108882932B (zh) 2016-02-09 2021-07-23 伊西康有限责任公司 具有非对称关节运动构造的外科器械
US10245030B2 (en) 2016-02-09 2019-04-02 Ethicon Llc Surgical instruments with tensioning arrangements for cable driven articulation systems
CA3014316C (en) 2016-02-10 2025-08-12 Microvention, Inc. Devices for vascular occlusion
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10448948B2 (en) 2016-02-12 2019-10-22 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10258331B2 (en) 2016-02-12 2019-04-16 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US10485542B2 (en) 2016-04-01 2019-11-26 Ethicon Llc Surgical stapling instrument comprising multiple lockouts
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US10492783B2 (en) 2016-04-15 2019-12-03 Ethicon, Llc Surgical instrument with improved stop/start control during a firing motion
US10828028B2 (en) 2016-04-15 2020-11-10 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US10405859B2 (en) 2016-04-15 2019-09-10 Ethicon Llc Surgical instrument with adjustable stop/start control during a firing motion
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US20170296173A1 (en) 2016-04-18 2017-10-19 Ethicon Endo-Surgery, Llc Method for operating a surgical instrument
US10368867B2 (en) 2016-04-18 2019-08-06 Ethicon Llc Surgical instrument comprising a lockout
BR112018076831B1 (pt) 2016-06-24 2023-01-31 Ethicon Llc Sistema de grampeamento cirúrgico
USD847989S1 (en) 2016-06-24 2019-05-07 Ethicon Llc Surgical fastener cartridge
US10675024B2 (en) 2016-06-24 2020-06-09 Ethicon Llc Staple cartridge comprising overdriven staples
USD850617S1 (en) 2016-06-24 2019-06-04 Ethicon Llc Surgical fastener cartridge
USD826405S1 (en) 2016-06-24 2018-08-21 Ethicon Llc Surgical fastener
CN109310431B (zh) 2016-06-24 2022-03-04 伊西康有限责任公司 包括线材钉和冲压钉的钉仓
US10828039B2 (en) 2016-06-27 2020-11-10 Covidien Lp Electrolytic detachment for implantable devices
US10828037B2 (en) 2016-06-27 2020-11-10 Covidien Lp Electrolytic detachment with fluid electrical connection
US11051822B2 (en) 2016-06-28 2021-07-06 Covidien Lp Implant detachment with thermal activation
US10779906B2 (en) 2016-07-13 2020-09-22 Cygnus Medical, Llc Cleaning device with microfiber tails
US10478195B2 (en) 2016-08-04 2019-11-19 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
US10500000B2 (en) 2016-08-16 2019-12-10 Ethicon Llc Surgical tool with manual control of end effector jaws
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
WO2018055433A1 (en) 2016-09-21 2018-03-29 Peter Law Autonomously controllable pull wire injection catheter, robotic system comprising said catheter and method for operating the same
US10576099B2 (en) 2016-10-21 2020-03-03 Covidien Lp Injectable scaffold for treatment of intracranial aneurysms and related technology
CN107970053B (zh) * 2016-10-21 2022-01-28 上海佐心医疗科技有限公司 左心耳封堵装置
JP7010956B2 (ja) 2016-12-21 2022-01-26 エシコン エルエルシー 組織をステープル留めする方法
US10499914B2 (en) 2016-12-21 2019-12-10 Ethicon Llc Staple forming pocket arrangements
US10687809B2 (en) 2016-12-21 2020-06-23 Ethicon Llc Surgical staple cartridge with movable camming member configured to disengage firing member lockout features
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
CN110099619B (zh) 2016-12-21 2022-07-15 爱惜康有限责任公司 用于外科端部执行器和可替换工具组件的闭锁装置
US11090048B2 (en) 2016-12-21 2021-08-17 Cilag Gmbh International Method for resetting a fuse of a surgical instrument shaft
US10993715B2 (en) 2016-12-21 2021-05-04 Ethicon Llc Staple cartridge comprising staples with different clamping breadths
US11684367B2 (en) 2016-12-21 2023-06-27 Cilag Gmbh International Stepped assembly having and end-of-life indicator
US10667811B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Surgical stapling instruments and staple-forming anvils
US10813638B2 (en) 2016-12-21 2020-10-27 Ethicon Llc Surgical end effectors with expandable tissue stop arrangements
US10687810B2 (en) 2016-12-21 2020-06-23 Ethicon Llc Stepped staple cartridge with tissue retention and gap setting features
US20180168625A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Surgical stapling instruments with smart staple cartridges
US10973516B2 (en) 2016-12-21 2021-04-13 Ethicon Llc Surgical end effectors and adaptable firing members therefor
US10426471B2 (en) 2016-12-21 2019-10-01 Ethicon Llc Surgical instrument with multiple failure response modes
US10945727B2 (en) 2016-12-21 2021-03-16 Ethicon Llc Staple cartridge with deformable driver retention features
US10918385B2 (en) 2016-12-21 2021-02-16 Ethicon Llc Surgical system comprising a firing member rotatable into an articulation state to articulate an end effector of the surgical system
US10888322B2 (en) 2016-12-21 2021-01-12 Ethicon Llc Surgical instrument comprising a cutting member
US20180168615A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US10448950B2 (en) 2016-12-21 2019-10-22 Ethicon Llc Surgical staplers with independently actuatable closing and firing systems
US20180168647A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Surgical stapling instruments having end effectors with positive opening features
CN110087565A (zh) 2016-12-21 2019-08-02 爱惜康有限责任公司 外科缝合系统
JP7010957B2 (ja) 2016-12-21 2022-01-26 エシコン エルエルシー ロックアウトを備えるシャフトアセンブリ
JP2020501815A (ja) 2016-12-21 2020-01-23 エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ 外科用ステープル留めシステム
US10856868B2 (en) 2016-12-21 2020-12-08 Ethicon Llc Firing member pin configurations
US10667809B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Staple cartridge and staple cartridge channel comprising windows defined therein
MX2019007295A (es) 2016-12-21 2019-10-15 Ethicon Llc Sistema de instrumento quirúrgico que comprende un bloqueo del efector de extremo y un bloqueo de la unidad de disparo.
JP2020515592A (ja) * 2017-03-27 2020-05-28 ドン，ヨンファ 連鎖薬物構造およびその製造装置と保存装置
CN110996805B (zh) 2017-05-25 2024-03-19 泰尔茂株式会社 粘合封堵系统
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
US12490980B2 (en) 2017-06-20 2025-12-09 Cilag Gmbh International Surgical instrument having controllable articulation velocity
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10368864B2 (en) 2017-06-20 2019-08-06 Ethicon Llc Systems and methods for controlling displaying motor velocity for a surgical instrument
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
US10390841B2 (en) 2017-06-20 2019-08-27 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US10631859B2 (en) 2017-06-27 2020-04-28 Ethicon Llc Articulation systems for surgical instruments
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US10211586B2 (en) 2017-06-28 2019-02-19 Ethicon Llc Surgical shaft assemblies with watertight housings
US11083455B2 (en) 2017-06-28 2021-08-10 Cilag Gmbh International Surgical instrument comprising an articulation system ratio
USD851762S1 (en) 2017-06-28 2019-06-18 Ethicon Llc Anvil
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US10786253B2 (en) 2017-06-28 2020-09-29 Ethicon Llc Surgical end effectors with improved jaw aperture arrangements
USD854151S1 (en) 2017-06-28 2019-07-16 Ethicon Llc Surgical instrument shaft
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
EP4070740B1 (en) 2017-06-28 2025-03-26 Cilag GmbH International Surgical instrument comprising selectively actuatable rotatable couplers
USD869655S1 (en) 2017-06-28 2019-12-10 Ethicon Llc Surgical fastener cartridge
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
US10258418B2 (en) 2017-06-29 2019-04-16 Ethicon Llc System for controlling articulation forces
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US10398434B2 (en) 2017-06-29 2019-09-03 Ethicon Llc Closed loop velocity control of closure member for robotic surgical instrument
US11944300B2 (en) 2017-08-03 2024-04-02 Cilag Gmbh International Method for operating a surgical system bailout
US11974742B2 (en) 2017-08-03 2024-05-07 Cilag Gmbh International Surgical system comprising an articulation bailout
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
US10675036B2 (en) 2017-08-22 2020-06-09 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10729501B2 (en) 2017-09-29 2020-08-04 Ethicon Llc Systems and methods for language selection of a surgical instrument
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
US10796471B2 (en) 2017-09-29 2020-10-06 Ethicon Llc Systems and methods of displaying a knife position for a surgical instrument
CN111200976B (zh) 2017-10-09 2023-07-07 微仙美国有限公司 放射性液体栓塞
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US12336705B2 (en) 2017-12-21 2025-06-24 Cilag Gmbh International Continuous use self-propelled stapling instrument
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11369368B2 (en) 2017-12-21 2022-06-28 Cilag Gmbh International Surgical instrument comprising synchronized drive systems
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
US20200054321A1 (en) 2018-08-20 2020-02-20 Ethicon Llc Surgical instruments with progressive jaw closure arrangements
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US11272945B2 (en) 2018-10-10 2022-03-15 Innova Vascular, Inc. Device for removing an embolus
US11564692B2 (en) 2018-11-01 2023-01-31 Terumo Corporation Occlusion systems
US11678887B2 (en) 2018-12-17 2023-06-20 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
US11291453B2 (en) 2019-03-15 2022-04-05 Sequent Medical, Inc. Filamentary devices having a flexible joint for treatment of vascular defects
WO2020190639A1 (en) 2019-03-15 2020-09-24 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US11559309B2 (en) 2019-03-15 2023-01-24 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11752020B2 (en) * 2019-06-19 2023-09-12 Michael J. Spearman Tool for placement of degradable ostial stent
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11350938B2 (en) 2019-06-28 2022-06-07 Cilag Gmbh International Surgical instrument comprising an aligned rfid sensor
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
US12004740B2 (en) 2019-06-28 2024-06-11 Cilag Gmbh International Surgical stapling system having an information decryption protocol
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US11504816B2 (en) 2019-11-04 2022-11-22 Covidien Lp Systems and methods for treating aneurysms
US12324890B2 (en) 2019-12-03 2025-06-10 Boston Scientific Scimed, Inc. Medical delivery device and method of use
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
US11931033B2 (en) 2019-12-19 2024-03-19 Cilag Gmbh International Staple cartridge comprising a latch lockout
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US12035913B2 (en) 2019-12-19 2024-07-16 Cilag Gmbh International Staple cartridge comprising a deployable knife
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US12023034B2 (en) 2020-03-11 2024-07-02 Microvention, Inc. Devices for treatment of vascular defects
US20210282789A1 (en) 2020-03-11 2021-09-16 Microvention, Inc. Multiple layer devices for treatment of vascular defects
US12070220B2 (en) 2020-03-11 2024-08-27 Microvention, Inc. Devices having multiple permeable shells for treatment of vascular defects
WO2021222392A1 (en) 2020-04-28 2021-11-04 Terumo Corporation Occlusion systems
US11931041B2 (en) 2020-05-12 2024-03-19 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
US11826013B2 (en) 2020-07-28 2023-11-28 Cilag Gmbh International Surgical instruments with firing member closure features
US12053175B2 (en) 2020-10-29 2024-08-06 Cilag Gmbh International Surgical instrument comprising a stowed closure actuator stop
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11931025B2 (en) 2020-10-29 2024-03-19 Cilag Gmbh International Surgical instrument comprising a releasable closure drive lock
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US12471982B2 (en) 2020-12-02 2025-11-18 Cilag Gmbh International Method for tissue treatment by surgical instrument
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11944296B2 (en) 2020-12-02 2024-04-02 Cilag Gmbh International Powered surgical instruments with external connectors
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
AU2021420567A1 (en) * 2021-01-12 2023-07-13 Clearstream Technologies Limited Embolisation system for promoting blood clot formation
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US12108951B2 (en) 2021-02-26 2024-10-08 Cilag Gmbh International Staple cartridge comprising a sensing array and a temperature control system
US11950777B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Staple cartridge comprising an information access control system
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11950779B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Method of powering and communicating with a staple cartridge
US11925349B2 (en) 2021-02-26 2024-03-12 Cilag Gmbh International Adjustment to transfer parameters to improve available power
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US12324580B2 (en) 2021-02-26 2025-06-10 Cilag Gmbh International Method of powering and communicating with a staple cartridge
US11980362B2 (en) 2021-02-26 2024-05-14 Cilag Gmbh International Surgical instrument system comprising a power transfer coil
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US12102323B2 (en) 2021-03-24 2024-10-01 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising a floatable component
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11944336B2 (en) 2021-03-24 2024-04-02 Cilag Gmbh International Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US20220378426A1 (en) 2021-05-28 2022-12-01 Cilag Gmbh International Stapling instrument comprising a mounted shaft orientation sensor
US12446891B2 (en) 2021-08-30 2025-10-21 Microvention, Inc. Devices for treatment of vascular defects
US11980363B2 (en) 2021-10-18 2024-05-14 Cilag Gmbh International Row-to-row staple array variations
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
US12239317B2 (en) 2021-10-18 2025-03-04 Cilag Gmbh International Anvil comprising an arrangement of forming pockets proximal to tissue stop
US11957337B2 (en) 2021-10-18 2024-04-16 Cilag Gmbh International Surgical stapling assembly with offset ramped drive surfaces
US12089841B2 (en) 2021-10-28 2024-09-17 Cilag CmbH International Staple cartridge identification systems
US12432790B2 (en) 2021-10-28 2025-09-30 Cilag Gmbh International Method and device for transmitting UART communications over a security short range wireless communication
US11937816B2 (en) 2021-10-28 2024-03-26 Cilag Gmbh International Electrical lead arrangements for surgical instruments
CN114366212B (zh) * 2022-01-20 2024-03-12 苏州大学附属第一医院 一种用于临时性动脉栓塞的明胶海绵条输送系统
WO2025165348A1 (en) * 2024-01-30 2025-08-07 Clearstream Technologies Limited Embolization devices and methods thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364392A (en) * 1980-12-04 1982-12-21 Wisconsin Alumni Research Foundation Detachable balloon catheter
EP0375775A1 (en) * 1986-11-29 1990-07-04 Terumo Kabushiki Kaisha Catheter equipped with balloon
JPH0447416U (ja) * 1990-08-23 1992-04-22
WO1993016650A1 (en) * 1992-02-24 1993-09-02 Regents Of The University Of California Endovascular electrolytically detachable wire for thrombus formation
JPH07508909A (ja) * 1992-11-18 1995-10-05 ターゲット　セラピューティクス，インコーポレイテッド 超軟質の塞栓デバイスおよびその使用方法
WO1997027893A1 (en) * 1996-02-02 1997-08-07 Transvascular, Inc. Methods and apparatus for blocking flow through blood vessels
US5749894A (en) * 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
WO1999022651A1 (en) * 1997-10-30 1999-05-14 Kaneka Medix Corporation Medical device for disposing in vivo indwelling member and method of disposing the member
WO1999042038A1 (en) * 1998-02-18 1999-08-26 Boston Scientific Limited Vaso-occlusive member assembly with multiple detaching points

Family Cites Families (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2326159A (en) * 1940-11-01 1943-08-10 Mendel Alfred Finger stall, catheter, sheath, or the like
DE1875646U (de) 1959-04-21 1963-07-18 Willy Ruesch Katheter, insbesondere intratracheal-katheter.
US3058473A (en) 1959-11-27 1962-10-16 Alfred E Whitchead Remotely directing catheters and tools
SE336642B (ja) * 1969-10-28 1971-07-12 Astra Meditec Ab
US3656486A (en) * 1970-04-08 1972-04-18 Jack R Robertson Instrument for inserting a suprapubic catheter
US3656485A (en) * 1970-04-27 1972-04-18 Jack R Robertson Method of and apparatus for viewing the interior of the bladder through a suprapubic incision
SE383034B (sv) * 1974-04-08 1976-02-23 L I Brendling Slangventil
DE2541919A1 (de) 1975-09-19 1977-03-24 Hoffmann Klaus Intestinalsonde
US4346712A (en) * 1979-04-06 1982-08-31 Kuraray Company, Ltd. Releasable balloon catheter
SU889009A1 (ru) 1980-02-04 1981-12-15 Киевский научно-исследовательский институт клинической и экспериментальной хирургии Трубчатый наконечник дл проведени сосудистого шунта в ткан х
DE3010841A1 (de) * 1980-03-21 1981-10-08 Ulrich Dr.med. 6936 Haag Uthmann Katheder
US4395806A (en) * 1980-05-08 1983-08-02 Sorenson Research Co., Inc. Method of manufacturing a detachable balloon catheter assembly
US4468216A (en) 1982-05-20 1984-08-28 Rudolph Muto Irrigation suction catheter
US4545367A (en) 1982-07-16 1985-10-08 Cordis Corporation Detachable balloon catheter and method of use
US4631188A (en) 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
JPS60155774U (ja) 1984-03-28 1985-10-17 株式会社小松製作所 エンジンの燃料噴射装置
JPH0678460B2 (ja) * 1985-05-01 1994-10-05 株式会社バイオマテリアル・ユニバース 多孔質透明ポリビニルアルユールゲル
US4808155A (en) * 1986-02-27 1989-02-28 Mahurkar Sakharam D Simple double lumen catheter
US4698056A (en) 1986-03-21 1987-10-06 Medi-Tech, Inc. Enteric feeding device
US4739768B2 (en) * 1986-06-02 1995-10-24 Target Therapeutics Inc Catheter for guide-wire tracking
DE3632573C1 (en) 1986-09-25 1988-04-21 Sterimed Gmbh Probe with insertion aid
US4863442A (en) * 1987-08-14 1989-09-05 C. R. Bard, Inc. Soft tip catheter
US4819637A (en) * 1987-09-01 1989-04-11 Interventional Therapeutics Corporation System for artificial vessel embolization and devices for use therewith
CH673432A5 (ja) * 1987-09-23 1990-03-15 Fischer Ag Georg
US5041090A (en) * 1988-01-12 1991-08-20 Scheglov Viktor I Occluding device
US4884579A (en) 1988-04-18 1989-12-05 Target Therapeutics Catheter guide wire
US4936835A (en) * 1988-05-26 1990-06-26 Haaga John R Medical needle with bioabsorbable tip
US5080655A (en) * 1988-05-26 1992-01-14 Haaga John R Medical biopsy needle
US5092848A (en) * 1988-10-13 1992-03-03 Deciutiis Vincent L Intravenous catheter with built-in cutting tip and method for making the same
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
FR2641692A1 (fr) 1989-01-17 1990-07-20 Nippon Zeon Co Bouchon de fermeture d'une breche pour application medicale et dispositif pour bouchon de fermeture l'utilisant
US4932938A (en) * 1989-05-05 1990-06-12 Medical Engineering Corporation Urethral indwelling catheter with incontinence control
DE3916648C1 (ja) * 1989-05-22 1990-09-06 Fa. Carl Freudenberg, 6940 Weinheim, De
US5084063A (en) * 1989-09-27 1992-01-28 United States Surgical Corporation Surgical needle-suture attachment
JP2809765B2 (ja) 1989-11-28 1998-10-15 住友ベークライト株式会社 腸管内挿入カテーテル
US5092873A (en) 1990-02-28 1992-03-03 Devices For Vascular Intervention, Inc. Balloon configuration for atherectomy catheter
US6083220A (en) * 1990-03-13 2000-07-04 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5122136A (en) * 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
DE4008391C1 (ja) 1990-03-16 1991-10-17 Vygon Gmbh & Co Kg, 5100 Aachen, De
US5108407A (en) * 1990-06-08 1992-04-28 Rush-Presbyterian St. Luke's Medical Center Method and apparatus for placement of an embolic coil
US5221267A (en) * 1990-11-30 1993-06-22 Fresenius Usa, Inc. Breakable tubing coupling
US5167622A (en) 1990-12-07 1992-12-01 Smiths Industries Medical Systems, Inc. Triple conduit suction catheter
US5207648A (en) * 1990-12-14 1993-05-04 The Kendall Company Multilumen catheter
US6524274B1 (en) * 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5156596A (en) 1991-02-04 1992-10-20 Menlo Care, Inc. Catheter with changeable number of lumens
US5215530A (en) * 1991-07-11 1993-06-01 City Of Hope Sleeved extension and anchoring system for percutaneous catheters
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
JP3393383B2 (ja) * 1992-01-21 2003-04-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 中隔欠損閉鎖装置
DE9203077U1 (de) 1992-03-05 1992-07-30 Fuhrmann, Dörte, 14167 Berlin Flexibler Metallkatheter
FR2689388B1 (fr) 1992-04-07 1999-07-16 Celsa Lg Filtre sanguin perfectionne eventuellement resorbable.
US5263964A (en) 1992-05-06 1993-11-23 Coil Partners Ltd. Coaxial traction detachment apparatus and method
US5360418A (en) 1992-07-15 1994-11-01 Sherwood Medical Company Connector for a thoracic catheter
US5360414A (en) 1992-10-08 1994-11-01 Yarger Richard J Tube for draining body cavities, viscera and wounds
US5382260A (en) 1992-10-30 1995-01-17 Interventional Therapeutics Corp. Embolization device and apparatus including an introducer cartridge and method for delivering the same
US5443454A (en) * 1992-12-09 1995-08-22 Terumo Kabushiki Kaisha Catheter for embolectomy
WO1994023786A1 (en) 1993-04-13 1994-10-27 Boston Scientific Corporation Prosthesis delivery system
US5405339A (en) * 1993-09-03 1995-04-11 Medtronic, Inc. Medical connector and method for connecting medical tubing
DE4333070C2 (de) 1993-09-29 1995-08-31 Sterimed Gmbh Schlauchverbinder
US5395353A (en) * 1993-11-02 1995-03-07 Vascular Technologies, Inc. Guiding catheter with controllable perfusion ports
US5795331A (en) * 1994-01-24 1998-08-18 Micro Therapeutics, Inc. Balloon catheter for occluding aneurysms of branch vessels
JPH09510637A (ja) 1994-03-18 1997-10-28 クック インコーポレイティッド 螺旋状塞栓形成コイル
US5569221A (en) * 1994-07-07 1996-10-29 Ep Technologies, Inc. Catheter component bond and method
JPH10504210A (ja) 1994-08-17 1998-04-28 ボストン サイエンティフィック コーポレイション インプラント、移植方法、及び適用装置
DE69534233T2 (de) * 1994-09-16 2005-10-27 Ethicon Endo-Surgery, Inc., Cincinnati Vorrichtungen zum bestimmen und markieren von gewebe
US5570585A (en) 1994-10-03 1996-11-05 Vaynberg; Mikhail Universal cooling system automatically configured to operate in compound or single compressor mode
US5690671A (en) 1994-12-13 1997-11-25 Micro Interventional Systems, Inc. Embolic elements and methods and apparatus for their delivery
US5571168A (en) * 1995-04-05 1996-11-05 Scimed Lifesystems Inc Pull back stent delivery system
US6638291B1 (en) * 1995-04-20 2003-10-28 Micrus Corporation Three dimensional, low friction vasoocclusive coil, and method of manufacture
US6171326B1 (en) * 1998-08-27 2001-01-09 Micrus Corporation Three dimensional, low friction vasoocclusive coil, and method of manufacture
US5645558A (en) * 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
NO962336L (no) 1995-06-06 1996-12-09 Target Therapeutics Inc Vaso-okklusiv spiral
US5667767A (en) * 1995-07-27 1997-09-16 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US5580568A (en) * 1995-07-27 1996-12-03 Micro Therapeutics, Inc. Cellulose diacetate compositions for use in embolizing blood vessels
US5888546A (en) 1995-08-28 1999-03-30 The Regents Of The University Of California Embolic material for endovascular occlusion of abnormal vasculature and method for using the same
US5769882A (en) 1995-09-08 1998-06-23 Medtronic, Inc. Methods and apparatus for conformably sealing prostheses within body lumens
US5702361A (en) * 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
DE19610333A1 (de) * 1996-03-17 1997-09-18 M Dr Mausbach Verfahren und Vorrichtung zur Ablösung von Implantaten im menschlichen Körper mittels elektrischen Stroms
US5921954A (en) * 1996-07-10 1999-07-13 Mohr, Jr.; Lawrence G. Treating aneurysms by applying hardening/softening agents to hardenable/softenable substances
US5833644A (en) 1996-05-20 1998-11-10 Percusurge, Inc. Method for emboli containment
US6270477B1 (en) * 1996-05-20 2001-08-07 Percusurge, Inc. Catheter for emboli containment
WO1997045131A1 (en) 1996-05-31 1997-12-04 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US5782797A (en) * 1996-06-06 1998-07-21 Scimed Life Systems, Inc. Therapeutic infusion device
US5913848A (en) 1996-06-06 1999-06-22 Luther Medical Products, Inc. Hard tip over-the-needle catheter and method of manufacturing the same
US5728133A (en) * 1996-07-09 1998-03-17 Cardiologics, L.L.C. Anchoring device and method for sealing percutaneous punctures in vessels
US5695480A (en) * 1996-07-29 1997-12-09 Micro Therapeutics, Inc. Embolizing compositions
US5830178A (en) 1996-10-11 1998-11-03 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide
US5902310A (en) * 1996-08-12 1999-05-11 Ethicon Endo-Surgery, Inc. Apparatus and method for marking tissue
US5925683A (en) 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
US5958444A (en) 1997-06-13 1999-09-28 Micro Therapeutics, Inc. Method for treating urinary reflux
US5776097A (en) * 1996-12-19 1998-07-07 University Of California At Los Angeles Method and device for treating intracranial vascular aneurysms
US5791036A (en) * 1996-12-23 1998-08-11 Schneider (Usa) Inc Catheter transition system
US6258079B1 (en) * 1997-01-21 2001-07-10 Vasca, Inc. Method and systems for establishing vascular access
US5911737A (en) * 1997-02-28 1999-06-15 The Regents Of The University Of California Microfabricated therapeutic actuators
US5895378A (en) * 1997-05-29 1999-04-20 Target Therapeutics, Inc. Flow-directed catheter having multiple tapers and radio-opaque markers
US6139525A (en) * 1997-07-08 2000-10-31 Advanced Cardiovascular Systems, Inc. Fusion bonding of catheter components
US5951599A (en) * 1997-07-09 1999-09-14 Scimed Life Systems, Inc. Occlusion system for endovascular treatment of an aneurysm
US5928260A (en) * 1997-07-10 1999-07-27 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
US5984929A (en) * 1997-08-29 1999-11-16 Target Therapeutics, Inc. Fast detaching electronically isolated implant
US5895410A (en) * 1997-09-12 1999-04-20 B. Braun Medical, Inc. Introducer for an expandable vascular occlusion device
US6511468B1 (en) 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
US6146373A (en) * 1997-10-17 2000-11-14 Micro Therapeutics, Inc. Catheter system and method for injection of a liquid embolic composition and a solidification agent
US20040260333A1 (en) 1997-11-12 2004-12-23 Dubrul William R. Medical device and method
US6083967A (en) * 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6168570B1 (en) * 1997-12-05 2001-01-02 Micrus Corporation Micro-strand cable with enhanced radiopacity
US6136015A (en) * 1998-08-25 2000-10-24 Micrus Corporation Vasoocclusive coil
US6241691B1 (en) 1997-12-05 2001-06-05 Micrus Corporation Coated superelastic stent
NL1008178C2 (nl) 1998-02-02 1999-08-04 Cordis Europ Katheter en werkwijze voor het vervaardigen hiervan.
US6044845A (en) * 1998-02-03 2000-04-04 Salient Interventional Systems, Inc. Methods and systems for treating ischemia
ES2343228T3 (es) 1998-02-10 2010-07-26 Ethicon Endo-Surgery, Inc. Aparato de oclusion, de anclaje, de tensionado o de direccion por flujo.
US6022369A (en) * 1998-02-13 2000-02-08 Precision Vascular Systems, Inc. Wire device with detachable end
US6346091B1 (en) * 1998-02-13 2002-02-12 Stephen C. Jacobsen Detachable coil for aneurysm therapy
US6077260A (en) * 1998-02-19 2000-06-20 Target Therapeutics, Inc. Assembly containing an electrolytically severable joint for endovascular embolic devices
WO1999048548A1 (en) 1998-03-23 1999-09-30 Medtronic, Inc. Catheter having extruded radiopaque stripes embedded in soft tip and method of fabrication
US5957912A (en) * 1998-04-16 1999-09-28 Camino Neurocare, Inc. Catheter having distal stylet opening and connector
US6015424A (en) * 1998-04-28 2000-01-18 Microvention, Inc. Apparatus and method for vascular embolization
US6168615B1 (en) * 1998-05-04 2001-01-02 Micrus Corporation Method and apparatus for occlusion and reinforcement of aneurysms
DE29908453U1 (de) 1998-05-12 1999-09-23 Novartis Nutrition Ag, Bern Ostomie-Sondenplazierungsspitze
US6463317B1 (en) * 1998-05-19 2002-10-08 Regents Of The University Of Minnesota Device and method for the endovascular treatment of aneurysms
US6293960B1 (en) * 1998-05-22 2001-09-25 Micrus Corporation Catheter with shape memory polymer distal tip for deployment of therapeutic devices
US6051607A (en) * 1998-07-02 2000-04-18 Micro Therapeutics, Inc. Vascular embolizing compositions comprising ethyl lactate and methods for their use
US6165193A (en) 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
US6102917A (en) * 1998-07-15 2000-08-15 The Regents Of The University Of California Shape memory polymer (SMP) gripper with a release sensing system
US6093199A (en) * 1998-08-05 2000-07-25 Endovascular Technologies, Inc. Intra-luminal device for treatment of body cavities and lumens and method of use
US6179860B1 (en) * 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6224610B1 (en) * 1998-08-31 2001-05-01 Micrus Corporation Shape memory polymer intravascular delivery system with heat transfer medium
US6296622B1 (en) 1998-12-21 2001-10-02 Micrus Corporation Endoluminal device delivery system using axially recovering shape memory material
US6478773B1 (en) 1998-12-21 2002-11-12 Micrus Corporation Apparatus for deployment of micro-coil using a catheter
US6059769A (en) * 1998-10-02 2000-05-09 Medtronic, Inc. Medical catheter with grooved soft distal segment
US6277126B1 (en) * 1998-10-05 2001-08-21 Cordis Neurovascular Inc. Heated vascular occlusion coil development system
US6551340B1 (en) * 1998-10-09 2003-04-22 Board Of Regents The University Of Texas System Vasoocclusion coil device having a core therein
US6152144A (en) 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6245053B1 (en) * 1998-11-09 2001-06-12 Medtronic, Inc. Soft tip guiding catheter and method of fabrication
US6102932A (en) * 1998-12-15 2000-08-15 Micrus Corporation Intravascular device push wire delivery system
US6835185B2 (en) * 1998-12-21 2004-12-28 Micrus Corporation Intravascular device deployment mechanism incorporating mechanical detachment
US6203779B1 (en) * 1999-03-19 2001-03-20 Charlie Ricci Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
US6361528B1 (en) * 1999-04-05 2002-03-26 Acist Medical Systems, Inc. Dynamically compliant catheter
US6663607B2 (en) 1999-07-12 2003-12-16 Scimed Life Systems, Inc. Bioactive aneurysm closure device assembly and kit
US6368301B1 (en) * 1999-12-21 2002-04-09 Advanced Cardiovascular Systems, Inc. Catheter having a soft distal tip
AU2009282868B2 (en) 2008-08-19 2013-09-05 Covidien Lp Detachable tip microcatheter

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364392A (en) * 1980-12-04 1982-12-21 Wisconsin Alumni Research Foundation Detachable balloon catheter
EP0375775A1 (en) * 1986-11-29 1990-07-04 Terumo Kabushiki Kaisha Catheter equipped with balloon
JPH0447416U (ja) * 1990-08-23 1992-04-22
WO1993016650A1 (en) * 1992-02-24 1993-09-02 Regents Of The University Of California Endovascular electrolytically detachable wire for thrombus formation
JPH07508909A (ja) * 1992-11-18 1995-10-05 ターゲット　セラピューティクス，インコーポレイテッド 超軟質の塞栓デバイスおよびその使用方法
US5749894A (en) * 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
WO1997027893A1 (en) * 1996-02-02 1997-08-07 Transvascular, Inc. Methods and apparatus for blocking flow through blood vessels
WO1999022651A1 (en) * 1997-10-30 1999-05-14 Kaneka Medix Corporation Medical device for disposing in vivo indwelling member and method of disposing the member
WO1999042038A1 (en) * 1998-02-18 1999-08-26 Boston Scientific Limited Vaso-occlusive member assembly with multiple detaching points

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011519300A (ja) * 2008-05-01 2011-07-07 アニュクローズ エルエルシー 動脈瘤閉塞装置
US8974487B2 (en) 2008-05-01 2015-03-10 Aneuclose Llc Aneurysm occlusion device
WO2010067463A1 (ja) * 2008-12-10 2010-06-17 株式会社カルディオ 大動脈弁置換手術用の組織片捕捉具および大動脈弁置換手術における組織片捕捉方法
JP2012100833A (ja) * 2010-11-09 2012-05-31 Goodman Co Ltd 医療用器具
JP2014030721A (ja) * 2012-08-06 2014-02-20 Covidien Lp 塞栓組成物を送達するための装置および方法
KR20170003497A (ko) * 2012-08-06 2017-01-09 코비디엔 엘피 색전 조성물을 전달하기 위한 장치 및 방법
US10188396B2 (en) 2012-08-06 2019-01-29 Covidien Lp Apparatus and method for delivering an embolic composition
KR102154491B1 (ko) * 2012-08-06 2020-09-10 코비디엔 엘피 색전 조성물을 전달하기 위한 장치 및 방법
WO2016153072A1 (ja) * 2015-03-26 2016-09-29 国立大学法人信州大学 血液凝固剤溶液、血液凝固剤溶液の製造方法、および液体の血液塞栓性タンパク質固有組成物ｅ２ｐの製造方法
JP6047689B1 (ja) * 2015-03-26 2016-12-21 国立大学法人信州大学 血液凝固剤溶液、血液凝固剤溶液の製造方法、および液体の血液塞栓性タンパク質固有組成物ｅ２ｐの製造方法
WO2023042909A1 (ja) * 2021-09-17 2023-03-23 テルモ株式会社 カテーテルおよび塞栓物装填済みカテーテル

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US9358014B2 (en) 2016-06-07
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DE60014672D1 (de) 2004-11-11
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WO2001015608A1 (en) 2001-03-08
US6511468B1 (en) 2003-01-28
JP2012232166A (ja) 2012-11-29
ATE278359T1 (de) 2004-10-15
US8454649B2 (en) 2013-06-04
CA2379442A1 (en) 2001-03-08
US20110264073A1 (en) 2011-10-27
US20030040733A1 (en) 2003-02-27
US7976527B2 (en) 2011-07-12
JP2011019930A (ja) 2011-02-03

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