JP2003265613A - Method for controlling catheter with expander, blood specimen collection controller and catheter with expander - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for controlling a catheter with an expander which can implement a method of forming a blood specimen collection circuit and blood return circuit for extracorporeal circulation by inserting the catheter into a blood vessel from one point thereof with high efficiency of a blood cleaning effect without the occurrence of various failures occurring in the long-time oppression at a local point. <P>SOLUTION: The catheter with the expander has a lumen and a shaft section having the expander 14, in which the lumen has an external opening at the proximal portion of that shaft section and is connected to an extracorporeal circulation circuit at the proximal end of the shaft portion and the expander exists nearer the distal end side than the external opening 18 in the distal portion of the shaft section. The method for controlling the catheter with the expander for the case blood specimen collection and blood return are intermittently performed by inserting the distal portion of such catheter with the expander into the blood vessel in a manner as to allow its distal end to face upstream of the flow of the blood comprises putting the expander into a shrunk state when collecting the blood specimen from the blood vessel and putting the expander into an expanded state when returning ten blood to the blood vessel. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is used for hemodialysis therapy, emergency blood purification therapy, etc., and is for controlling a catheter with a dilator, which is used for extracorporeal circulation in which blood collection and blood return are performed from a single blood vessel. The present invention relates to a method, a blood collection control device, and a catheter with a dilator.

[0002]

2. Description of the Related Art Conventionally, in hemodialysis therapy, emergency blood purification therapy, etc., a blood sampling circuit for extracorporeal circulation is used by inserting a catheter from one place of a blood vessel in order to reduce the invasion of a patient and to perform prompt treatment. And a blood return circuit (single needle method) have been proposed (Japanese Patent Laid-Open No. 50-551).
No. 98, etc.) is actually implemented. However, in the above method, since the blood collection site and the blood return site are close to each other in the blood vessel, the blood purified by the extracorporeal circulation is collected from the blood collection site together with the unpurified blood immediately after being returned to the blood vessel. Therefore, there is a problem that the efficiency of blood purification by extracorporeal circulation is reduced.

For the purpose of solving this problem, Japanese Unexamined Patent Publication No. 8-131547 proposes a double lumen catheter with a balloon provided with a balloon between a blood collecting port and a blood returning port. This catheter is used by placing the tip opening of the catheter along the direction of blood flow in a vein and then supplying a pressurized fluid to the balloon. As a result, the outer wall of the balloon blocks the inner wall of the blood vessel and blocks the flow of blood to separate the blood collection port and the blood return port, making it possible to completely separate the blood before dialysis and the blood after dialysis. .

However, according to the description of the above publication,
If the balloon completely blocks the blood vessel, it may occur during blood purification therapy (for dialysis, for example,
3-4 hours), the inner wall of the blood vessel will continue to be compressed by the balloon. As a result, the cells on the inner wall are no longer supplied with nutrients, and the local area (the place where the balloon is pressed) is physically damaged, resulting in defects such as hematoma formation and blood vessel occlusion due to thrombus formation and eventually damage to the blood vessel wall. Get up. Also, due to deterioration of the balloon itself or bulging of the inner wall of the blood vessel, a gap is created between the balloon and the inner wall of the blood vessel, and blood bleeding into the blood purifier and blood flowing in from the blood purifier are mixed. Sometimes. In many cases, the efficiency of blood purifying action, which is considered to be caused by these, decreases.
Therefore, a method of forming a blood collection circuit and a blood return circuit for extracorporeal circulation by inserting a catheter from one location of a blood vessel is
Despite the advantage of requiring only one puncture, it has not been widely used in clinical practice.

[0005]

DISCLOSURE OF THE INVENTION The present invention provides a method for forming a blood collecting circuit and a blood returning circuit for extracorporeal circulation by inserting a catheter from one place of a blood vessel, with high blood processing efficiency.
Moreover, it is an object of the present invention to provide a method for controlling a catheter with an expandable body, a blood collection control device, and a catheter with an expandable body that can be implemented without causing various problems due to local long-term compression.

[0006]

The present invention includes the following (1).
~ (7) is provided.

(1) A shaft portion having a lumen and an expansion body capable of being in a contracted state and an expanded state, the lumen having an external opening at a distal portion of the shaft portion, and the shaft. Catheter with a dilator connected to an extracorporeal circulation circuit having a blood collection circuit and a blood return circuit in the proximal portion of the portion, and the dilator existing distally of the external opening in the distal portion of the shaft portion The method for controlling a catheter with an expandable body in the case where the distal end is inserted into a blood vessel so that the distal end faces upstream of the blood flow, and blood sampling and blood return are performed intermittently, A method of controlling a catheter with an expandable body, wherein the expandable body is in a contracted state when blood is collected from the blood vessel, and the expandable body is in an expanded state when blood is returned to the blood vessel (first aspect of the present invention).

(2) A shaft portion having a lumen and an expandable body capable of being in a contracted state and an expanded state, the lumen having an external opening at a distal portion of the shaft portion, and the shaft. A catheter with an expandable body connected to an extracorporeal circulation circuit having a blood collecting circuit and a blood returning circuit at a proximal portion of the shaft portion, wherein the expandable body is present at a distal end side of the external opening at a distal portion of the shaft portion. A method for controlling a catheter with an expandable body in the case where the distal portion is inserted into a blood vessel so that the distal end faces downstream of the blood flow, and blood sampling and blood returning are performed intermittently, A method for controlling a catheter with an expandable body, wherein the expandable body is in an expanded state when collecting blood from a blood vessel, and the expandable body is in a contracted state when returning blood to the blood vessel (second aspect of the present invention).

(3) First lumen, second lumen,
A blood sample having a shaft portion having an expanded body that can be in a contracted state and an expanded state, the first lumen having an external opening at a distal portion of the shaft portion, and a proximal portion of the shaft portion. Connected to the blood return circuit of an extracorporeal circulation circuit having a circuit and a blood return circuit, the expansion body is present on the distal end side of the outer opening in the distal portion of the shaft portion, and the second lumen is the An outer opening on the distal end side of the expansion body at the distal portion of the shaft portion, and
A catheter with a dilator connected to the blood collection circuit of the extracorporeal circulation circuit at the proximal portion of the shaft portion is inserted into the blood vessel so that the distal end faces upstream of blood flow. A method of controlling a catheter with a dilator when intermittently collecting blood and returning blood, wherein the dilator is in a contracted state when blood is collected from the blood vessel, and the dilator is expanded when blood is returned to the blood vessel. State,
A method for controlling a catheter with an expandable body (third aspect of the present invention).

(4) First lumen and second lumen
A blood sample having a shaft portion having an expanded body that can be in a contracted state and an expanded state, the first lumen having an external opening at a distal portion of the shaft portion, and a proximal portion of the shaft portion. Connected to the blood collection circuit of an extracorporeal circulation circuit having a circuit and a blood return circuit, the expansion body is present at a distal end side of the external opening in the distal portion of the shaft portion, and the second lumen is the shaft. An outer opening on the distal end side of the expansion body at the distal portion of the portion, and
A catheter with a dilator connected to the blood return circuit of the extracorporeal circulation circuit at the proximal portion of the shaft portion is inserted into the blood vessel so that the distal end faces downstream of blood flow. A method of controlling a catheter with an expander in the case of performing blood collection and blood return intermittently, wherein the blood expander is placed in an expanded state when blood is collected from the blood vessel, and the blood expander is returned when returning blood to the blood vessel. Contracted,
A method for controlling a catheter with an expander (fourth aspect of the present invention).

(5) An extracorporeal circulation circuit having a blood collecting circuit and a blood returning circuit, a lumen, and a shaft portion having an expander capable of being in a contracted state and an expanded state, the lumen being the shaft portion. The distal portion has an external opening, and the proximal portion of the shaft portion is connected to the extracorporeal circulation circuit, and the expansion body is located at the distal end side of the external opening in the distal portion of the shaft portion. A catheter with an expandable body for use in inserting the distal portion of the catheter with the expandable body into a blood vessel to intermittently perform blood collection and blood return, and the extracorporeal circulation circuit and the expandable body A blood collection control device for controlling an attached catheter; a flow path control means for controlling a flow path opening / closing means of the extracorporeal circulation circuit, and an expansion body control means for controlling an expansion body expansion / contraction means of the catheter with an expansion body An operation control means for controlling the flow path control means and the expansion body control means; the flow path control means drives the flow path opening / closing means in accordance with a command from the operation control means, When collecting blood from a blood vessel, blood is allowed to flow into the blood collecting circuit, and when returning blood to the blood vessel, blood is allowed to flow out from the blood returning circuit; the dilator control means, in response to a command from the operation control means, When the expansion body expansion / contraction means is driven and the distal end is inserted into the blood vessel so as to face the upstream of the blood flow, when the blood is collected from the blood vessel, the expansion body is brought into a contracted state, When the blood is returned to the expanded body, the expanded body is in an expanded state, and when the distal end is inserted into a blood vessel so as to face the downstream of the blood flow, when the blood is collected from the blood vessel, the expanded body is drawn. And an expanded state,
A blood collection control device (fifth aspect of the present invention) that brings the expansion body into a contracted state when returning blood to the blood vessel.

(6) A shaft portion having an extracorporeal circulation circuit having a blood collecting circuit and a blood returning circuit, a first lumen, a second lumen, and an expander capable of being in a contracted state and an expanded state, The first lumen has an external opening at the distal portion of the shaft portion, the expansion body is at the distal end side of the external opening at the distal portion of the shaft portion, and the second lumen is the shaft. In the case of having an external opening at the distal end side of the expansion body at the distal portion of the part and being inserted into a blood vessel so that the distal end faces upstream of blood flow, the second lumen is In the case where the blood vessel is connected to the blood collecting circuit, the first lumen is connected to the blood returning circuit, and the distal end is inserted into a blood vessel so as to face downstream of the blood flow, One lumen is the blood sampling circuit And a catheter with an expander connected to the second lumen and connected to the blood return circuit, the distal portion of the catheter with an expander is inserted into a blood vessel to collect blood and return blood. A blood sampling control device for controlling the extracorporeal circulation circuit and the catheter with an expander, which are used when performing intermittently; a flow channel control means for controlling a flow channel opening / closing means of the extracorporeal circulation circuit, and the expansion And a flow control means for controlling the flow path control means and the expansion body control means; and the flow path control means for controlling the movement. According to the command of the means, the flow path opening / closing means is driven so that blood is allowed to flow into the blood collecting circuit when collecting blood from the blood vessel, and blood is allowed to flow out from the blood returning circuit when returning to the blood vessel. However, in the case where the expansion body control means drives the expansion body expansion / contraction means in response to a command from the operation control means, and the distal end is inserted into the blood vessel so as to face upstream of the blood flow, ,
When the blood is collected from the blood vessel, the expansion body is in a contracted state, when the blood is returned to the blood vessel, the expansion body is in an expanded state, and the distal end is inserted into the blood vessel so as to face downstream of the blood flow. In the blood collection control device (6th aspect of the present invention), the dilatation body is in an expanded state when blood is collected from the blood vessel, and the dilation body is in a contracted state when blood is returned to the blood vessel.

(7) A shaft portion having a lumen and an expansion body capable of being in a contracted state and an expanded state, the lumen having at least one external opening at a distal portion of the shaft portion, and A distal end side of the at least one external opening that is connected to an extracorporeal circulation circuit having a blood collection circuit and a blood return circuit at a proximal portion of the shaft portion, And a catheter with an expandable body which is used by inserting the distal portion into a blood vessel (the seventh aspect of the present invention).

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, a method for controlling a catheter with an expandable body, a blood collection control device, and a catheter with an expandable body according to the present invention will be described in detail with reference to the preferred embodiments shown in the accompanying drawings. First, the catheter with an expandable body according to the seventh aspect of the present invention used in the method for controlling the catheter with an expandable body according to the first and second aspects of the present invention (hereinafter, also simply referred to as “the catheter of the present invention”). Will be described.

FIG. 1 is a schematic view showing an example of the distal portion of the catheter of the present invention. The catheter 10 of the present invention has a shaft portion 16 having a lumen 12 and an expansion body 14. Lumen 12 has at least one external opening 18 at the distal portion of shaft portion 16, as shown in FIG. Although there may be one external opening 18 as shown in FIG. 1, the lumen 12 may be branched to form two or more external openings.

The lumen 12 is used by being connected to an extracorporeal circulation circuit having a blood collecting circuit and a blood returning circuit in the proximal portion of the shaft portion 16. A blood processing device such as a hemodialyzer (dialyzer), a blood filter, and a plasma separator is usually provided between the blood collecting circuit and the blood returning circuit of the extracorporeal circulation circuit. Further, in the extracorporeal circulation circuit, a blood is usually provided in the blood collection circuit, the blood processing unit, and the blood return circuit in this order, so that a pump is usually provided in the blood collection circuit. Catheter 1 of the present invention
The extracorporeal circulation circuit to which 0 is connected is one in which the blood collection circuit and the blood return circuit merge at the portion connected to the catheter.
In other words, the portion connected to the catheter branches to form a blood collection circuit and a blood return circuit (see FIG. 5). Such an extracorporeal circulation circuit is disclosed in, for example, Japanese Patent Laid-Open No. 50-5.
The extracorporeal circulation circuit described in FIG. 1 of Japanese Unexamined Patent Publication No. 5198 and FIG. 2 in Japanese Unexamined Patent Publication No. 7-80063 can be used.

The expansion body 14 can be in a contracted state or an expanded state. The means is not particularly limited. In the illustrated example, the shaft portion 16 is provided with a fluid supply pipe 20, through which the fluid is expanded.
4 into the expanded state, and the fluid is expanded 14
It can be discharged from the inside and brought into a contracted state. The expandable body 14 has a distal end 2 with respect to all of the at least one external opening 18 at the distal portion of the shaft portion 16.
It exists on the second side. That is, when there are two or more external openings, the external opening existing closest to the distal end 22 is
The expansion body 14 exists on the distal end 22 side.

The material of each member of the catheter 10 of the present invention is not particularly limited. Examples of the material forming the expansion body 14 include polyurethane, polyvinyl chloride, polyethylene, polyamide, polyester, silicone resin,
Examples thereof include polystyrene-based thermoplastic elastomer, polyolefin-based thermoplastic elastomer, natural rubber, and various synthetic rubbers. Examples of the material forming the shaft portion 16 include polyvinyl chloride, polyethylene, polypropylene, polyester, and polyurethane.

The catheter of the present invention may have other members as long as it has the above-mentioned members. It is one of the preferable embodiments that the catheter of the present invention has a puncture needle. The puncture needle is not particularly limited, and a conventionally known one can be used.

FIG. 2 is a schematic sectional view showing an example of the catheter of the present invention having a puncture needle. The catheter 10 'of the present invention comprises a lumen 12', an expansion body 14 'and a puncture needle 1.
And a shaft portion 16 'having 5'. Lumen 1
2'is connected to an extracorporeal circulation circuit 38 described later at the proximal portion of the shaft portion 16 '.

In the catheter 10 'of the present invention, when the outer cylinder 16'a of the shaft portion 16' is fixed, the inner cylinder 16'b can slide in the direction of the arrow in FIG. 2 (a). It has become. In FIG. 2A, the shaft portion 1
The outer cylinder 16'a of 6'contains the expansion body 14 'inside. A lumen 12 'formed between the outer cylinder 16'a and the inner cylinder 16'b is closed at its distal end side by an expansion body 14'. When the inner cylinder 16'b of the shaft portion 16 'is slid from this state, as shown in FIG. 2 (b), at the distal portion of the shaft portion 16', the expansion body 14 'is exposed to the outside and at the same time. The expansion body 14 'and the outer cylinder 16'a are separated from each other, and an outer opening 18' is formed in the lumen 12 '. When using the catheter 10 'of the present invention, FIG.
Puncture is performed in a state where the expansion body 14 'as shown in (a) is stored, and blood collection and blood return are performed with the expansion body 14' as shown in FIG. 2 (b) being exposed. In the present invention,
Like the catheter 10 'of the present invention described above, the outer opening of the lumen may be formed by sliding the shaft portion.

The catheter 10 of the present invention is used by inserting the distal portion into a blood vessel. Hereinafter, regarding the control method of the catheter with an expandable body of the first and second aspects of the present invention,
The case of using the catheter 10 of the present invention will be described as an example.

As mentioned above, the catheter 10 of the present invention.
Is used by inserting the distal portion into a blood vessel. FIG. 3 is an explanatory diagram of an example of a method for controlling the catheter with an expandable body according to the first aspect of the present invention. In the first aspect of the present invention,
As shown in FIG. 3, the distal portion of the catheter 10 of the present invention is inserted into the blood vessel 2 with the distal end 22 pointing upstream of the blood flow. In this case, the blood vessel 2 is preferably an artery. Here, as shown in FIG. 3A, when the blood is collected from the blood vessel 2, the expandable body 14 is in a contracted state. Next, as shown in FIG. 3B, when the blood is returned to the blood vessel 2, the expandable body 14 is brought into an expanded state. Extension body 1
When 4 is in an expanded state, the blood that has passed through the extracorporeal circulation circuit (processed blood) does not reversely flow in the upstream direction or stay in the vicinity of the external opening 18 when returning, and the blood is rapidly Flow downstream. Next, as shown in FIG. 3A, when blood is collected from the blood vessel 2, the dilator 14
To the contracted state. At this point in time, the returned blood has already flowed to the downstream side, so blood that has flowed from the upstream side and has not passed through the extracorporeal circulation circuit (untreated blood) can be collected. Therefore, according to the method for controlling a catheter with a dilator according to the first aspect of the present invention, blood can be efficiently passed through the extracorporeal circulation circuit.

FIG. 4 is an explanatory view of an example of the method for controlling the catheter with an expandable body according to the second aspect of the present invention. In the second aspect of the present invention, as shown in FIG. 4, the distal portion of the catheter 10 of the present invention is inserted into the blood vessel 4 with the distal end 22 pointing downstream of the blood flow. In this case, the blood vessel 4 is preferably a vein. Here, FIG. 4 (a)
As shown in, when the blood is collected from the blood vessel 4, the expandable body 14 is kept in the expanded state. By placing the expandable body 14 in the expanded state, blood is blocked at the upstream side of the expandable body 14, and even if the blood vessel 4 is a blood vessel with a weak blood flow such as a vein, blood can be easily collected. Next, FIG.
As shown in (b), when returning blood to the blood vessel 4, the expansion body 14 is brought into a contracted state. When the expandable body 14 is in the contracted state, the blood that has passed through the extracorporeal circulation circuit flows downstream when the blood is returned. Next, as shown in FIG. 4A, when blood is collected from the blood vessel 4, the expandable body 14 is brought into the expanded state again. At this point in time, the returned blood has already flowed to the downstream side, so blood that has flowed from the upstream side and has not passed through the extracorporeal circulation circuit can be collected. Therefore, according to the method for controlling a catheter with a dilator according to the second aspect of the present invention, blood can be efficiently collected even in a blood vessel having a weak blood flow, and the blood can be efficiently passed through the extracorporeal circulation circuit. be able to.

Further, in the first and second aspects of the present invention, blood sampling and blood returning are performed intermittently. When blood sampling and blood returning are performed intermittently, the inner wall of the blood vessel does not continue to be pressed by the balloon, so that the cells on the inner wall are not supplied with nutrients, and the hematoma due to thrombus formation and damage to the blood vessel wall is not present. There are no problems such as formation and blood vessel obstruction. The cycle of repeating blood collection and blood return is not particularly limited, but it is preferable that both blood collection and blood return be 3 to 5 seconds.

In the first and second aspects of the present invention, as described above, it is preferable to use the catheter of the present invention because blood can be efficiently passed through the extracorporeal circulation circuit, but the present invention is not limited thereto. Alternatively, the expander can be used as long as it is a catheter located at the distal end side of at least one of the external openings in the distal portion of the shaft portion.

In the first and second aspects of the present invention, as described above, blood collection and blood return may be performed in conjunction with contraction and expansion of the expansion body 14, and its means is not particularly limited. It is preferable to use the blood collection control device of the fifth aspect of the present invention described below.

FIG. 5 is an explanatory diagram of an example of a blood processing system using the blood collection control device of the fifth aspect of the present invention. In FIG. 5, the catheter 10 of the present invention has been inserted into the blood vessel 2 with the distal end 22 pointing upstream of the blood flow. Further, the catheter 10 of the present invention has an expander expanding / contracting means 46 for expanding and contracting the expander 14 on the proximal end side. The expansion body expanding / contracting means 46 is not particularly limited, and a conventionally known one can be used. For example, when the expansion body 14 is in an expanded state or in a contracted state due to the introduction and discharge of a fluid as in the illustrated example, a fluid supply means such as a pump can be used.
Examples of the fluid in this case include gases such as air and carbon dioxide; liquids such as physiological saline and glycerin aqueous solution. In the illustrated example, the expansion body expanding / contracting means 46 introduces a fluid into the expansion body 14 through the fluid supply pipe 20 to bring the expansion body 14 into an expanded state, and discharges the fluid from the expansion body 14 to expand it. The body 14 is brought into a contracted state.

In the catheter 10 of the present invention, the blood collecting circuit 40 and the blood returning circuit 4 are provided in the proximal portion of the shaft portion 16.
And an extracorporeal circulation circuit 38 having a blood collection circuit 40 and a blood collection circuit 40. Between the blood collecting circuit 40 and the blood returning circuit 42 of the extracorporeal circulation circuit 38,
A blood processor 45 is provided.

In the illustrated example, the blood collection circuit 40 is provided with blood circulation means 41 for circulating blood in the extracorporeal circulation circuit 38. The blood circulation means 41 is not particularly limited, and any conventionally known one can be used. For example, a combination of a pump, a pressure reducing / pressurizing container and a one-way valve can be used. The blood circulation means 41 is the blood return circuit 4
2 may be provided, or the blood processing device 45 may be incorporated. Further, the blood circulation means 41 may be one that is continuously driven, or may be one that is repeatedly turned on and off at the timing of blood collection and blood return. In the latter case, the ON / OFF timing may be controlled by a command from the operation control means 36, or conversely, a command from the blood circulation means 41 may be used to control the flow path control means 32 of the operation control means 36 described later. The timing of the command to the expansion body control means 34 may be controlled.

The extracorporeal circulation circuit 38 has a flow passage opening / closing means 44. The flow path opening / closing means 44 is particularly limited as long as it allows blood to flow into the blood collecting circuit 40 when collecting blood from the blood vessel 2 and allows blood to flow out from the blood returning circuit 42 when returning blood to the blood vessel 2. Alternatively, the flow path opening / closing means 44a and 44b in the illustrated example may be provided in both the blood collecting circuit 40 and the blood returning circuit 42,
It may be provided on only one side, such as the device described in JP-A-58-25169. The flow path opening / closing means 44 can be, for example, a conventionally known flow path opening / closing means such as a clamp, a valve, or the blood circulation means itself. In the illustrated example, the blood collecting circuit 40 and the blood returning circuit 42 are provided with flow path opening / closing means 44a and 44b, respectively.
Is provided. Flow path opening / closing means 44a and 44b
Can take an open state and a closed state, respectively, the flow path opening / closing means 44a is open (the blood sampling circuit 40 is open), and the flow path opening / closing means 44b is closed (the blood return circuit 42).
Is in a closed state), blood is collected, the flow path opening / closing means 44a is closed (blood collection circuit 40 is closed), and the flow path opening / closing means 44b is open (blood return circuit 42 is open). In some cases, blood is returned.

Blood collection control device 30 of the fifth aspect of the present invention
Has a flow path control means 32, an expansion body control means 34, and an operation control means 36. The flow path control means 32 controls the flow path opening / closing means 44a and 44b of the extracorporeal circulation circuit 38 to open or close each of them. The expansion body control means 34 is the expansion body expansion / contraction means 4 of the catheter 10 of the present invention.
6 to control the fluid supply pipe 20 from the expansion body expansion / contraction means 46.
The fluid is introduced into the expansion body 14 through the expansion body 14 to bring the expansion body 14 into the expanded state, or the fluid is discharged from the inside of the expansion body 14 to the expansion body expanding / contracting means 46 so that the expansion body 14 is contracted.
The operation control means 36 controls the flow path control means 32 and the expansion body control means 34 in association with each other.

The operation of the blood collection control device 30 according to the fifth aspect of the present invention will be specifically described below. First, the time of collecting blood will be described. When collecting blood, the operation control means 36
The flow path control means 32 is instructed to drive the flow path opening / closing means 44a to open the blood sampling circuit 40, and to drive the flow path opening / closing means 44b to close the blood return circuit 42. In this state, the blood is collected from the blood vessel 2 through the lumen 12 and the confluence portion 43 by the action of the pump 41.
It flows into 0. In conjunction with this, the operation control means 36
The expansion body control means 34 is instructed to drive the expansion body expansion / contraction means 46 to discharge the fluid from the inside of the expansion body 14 through the fluid supply pipe 20 to bring the expansion body 14 into a contracted state. That is, the operation control unit 36 drives the flow channel control unit 32 to drive the flow channel opening / closing units 44a and 44b to open the blood collection circuit 40 and close the blood return circuit 42, thereby performing extracorporeal circulation. The circuit 38 is brought into a blood collecting state, and in conjunction with this, the expansion body control means 34 drives the expansion body expansion / contraction means 46 to bring the expansion body 14 into a contracted state.

Next, the time of returning blood will be described. At the time of returning blood, the operation control unit 36 commands the flow channel control unit 32 to drive the flow channel opening / closing unit 44a to drive the blood collection circuit 4.
0 is closed, and the flow path opening / closing means 44b is driven to open the blood return circuit 42. In this state, blood
The operation of the pump 41 causes the blood return circuit 42 to join the confluence section 43.
And through the lumen 12 to the blood vessel 2. In conjunction with this, the motion control means 36 controls the extension body control means 34.
To drive the expansion body expansion / contraction means 46 to introduce the fluid into the expansion body 14 through the fluid supply pipe 20.
The expansion body 14 is brought into an expanded state. That is, the operation control means 36
Means that the flow path control means 32 is connected to the flow path opening / closing means 44a and 44.
By driving b, the blood collection circuit 40 is closed and the blood return circuit 42 is opened to bring the extracorporeal circulation circuit 38 into the blood return state. In conjunction with this, the expansion body control means 34 The expansion body expansion / contraction means 46 is driven to move the expansion body 14
To the extended state.

As described above, in the blood collection control device of the fifth aspect of the present invention, when the distal end 22 is inserted into the blood vessel 2 so as to face the upstream of the blood flow, the flow path control means. By controlling the blood collection circuit 40 and the blood return circuit 42 and the expansion body 14 by the 32, the expansion body control means 34, and the operation control means 36, as shown in Table 1 below,
A method for controlling a catheter with an expandable body according to the first aspect of the present invention is realized.

[0036]

[Table 1]

The operation control means 36 controls the flow path control means 32 and the expansion body control means 34 by interlocking them at a predetermined timing, but the interlocking timing may be completely synchronized or the lumen. There may be a slight time difference in consideration of the amount of blood staying inside 12 and the expansion and / or contraction speed of expansion body 14.

Although not shown, contrary to FIG. 5,
When the distal end 22 is inserted into the blood vessel 4 so as to face downstream of the blood flow, the motion control means 36 controls the flow path control means 32 in the same manner as in FIG. The control means 34 is controlled in the opposite manner to the case of FIG. That is, the operation control means 36 drives the expansion body expansion / contraction means 46 at the time of blood collection, introduces the fluid into the expansion body 14 through the fluid supply tube 20, and puts the expansion body 14 in an expanded state.
At the time of returning blood, the expansion body expanding / contracting means 46 is driven to discharge the fluid from the inside of the expansion body 14 through the fluid supply pipe 20 to bring the expansion body 14 into a contracted state.

That is, in the blood collection control device according to the fifth aspect of the present invention, the blood vessel 4 is arranged so that the distal end 22 faces the downstream of the blood flow.
When it is inserted into the blood flow control circuit 32, the blood flow control means 32, the expansion body control means 34, and the operation control means 36, as shown in Table 2 below, the blood collection circuit 40 and the blood return circuit 42.
And the expansion body 14 are controlled to realize the method for controlling the catheter with the expansion body according to the second aspect of the present invention.

[0040]

[Table 2]

In FIG. 5, the flow path control means 32, the expansion body control means 34 and the operation control means 36 of the blood collection control device 30 of the fifth aspect of the present invention are shown as individual blocks, but these are shown. , May be integrally configured. Further, in the blood collection control device of the fifth aspect of the present invention, the individual means may be configured by hardware, may be configured by software, or both may be used together. It may be one.

For example, as the flow path control means 32 constituted by hardware, there is a solenoid having a magnetic force by energization and capable of opening and closing the flow path opening / closing means 44a and 44b. As the mechanism of the flow path control means 32 and the flow path opening / closing means 44,
For example, the mechanism described in Japanese Patent Application Laid-Open No. 7-80063 can be used.

Next, a catheter with an expandable body (hereinafter also referred to as a "second catheter") used in the method for controlling the catheter with an expandable body according to the third and fourth aspects of the present invention.
Will be described.

FIG. 6 is a schematic view showing an example of the distal portion of the second catheter. The second catheter 50 has a shaft portion 58 having a first lumen 52, a second lumen 54 and an expansion body 56. The first lumen 52 has at least one external opening 60 at the distal portion of the shaft portion 58, as shown in FIG. The number of the external openings 60 may be one as shown in FIG. 6, but the first lumen 52 may be branched to form two or more external openings.

The first lumen 52 is used by being connected to an extracorporeal circulation circuit having a blood collecting circuit and a blood returning circuit in the proximal portion of the shaft portion 58. An extracorporeal circulation circuit having a blood collection circuit and a blood return circuit may be the same as that of the catheter 10 of the present invention.
In the extracorporeal circulation circuit to which is connected, the blood collecting circuit and the blood returning circuit are separately connected to different lumens of the catheter (see FIG. 10). Therefore, it differs from the extracorporeal circulation circuit used for the catheter 10 of the present invention in that the blood collecting circuit and the blood returning circuit are not joined at the portion connected to the catheter.

Here, the first lumen 52 has a distal end 66.
Is inserted into the blood vessel so as to face upstream of the blood flow, it is connected to the blood return circuit, and when distal end 66 is inserted into the blood vessel so as to face downstream of the blood flow. , Connected with blood sampling circuit.

The second lumen 54 has an external opening 62 on the distal end side of the expansion body 56 at the distal portion of the shaft portion 58. Although the number of the external openings 62 may be one as shown in FIG. 6, the second lumen 54 may be branched to form two or more external openings. The second lumen 54 is
The first lumen 5 of the blood collecting circuit and the blood returning circuit of the extracorporeal circulation circuit at the proximal portion of the shaft portion 58.
2 is used by connecting to the one not connected.

In the illustrated example, the first lumen 52 and the second lumen 54 are independent of each other, but may be composed of a double tube. That is, the inner space of the inner pipe of the double pipe is one of the first lumen and the second lumen, and the space between the inner pipe and the outer pipe of the double pipe is one of the first lumen and the second lumen. It may be configured to be the other. In this case, at the distal portion of the second catheter 50, the outer opening of the first lumen and the outer opening of the second lumen are present on both sides (distal end side and proximal end side) of the dilation body. A structure in which the double pipe is branched may be used.

The expander 56 can be in a contracted state or an expanded state. The means is not particularly limited. In the illustrated example, the shaft portion 58 is provided with a fluid supply pipe 64, and the fluid is expanded through the fluid supply pipe 64.
6 into the expanded state, and the fluid is expanded 56
It can be discharged from the inside and brought into a contracted state. The expansion body 56 is located on the distal end 66 side of all of the at least one outer opening 60 of the first lumen 52 at the distal portion of the shaft portion 58, and at least one outer opening 62 of the second lumen 54. It is preferable that all of them are located on the proximal end side.

The material of each member of the second catheter 50 is
There is no particular limitation, and the same material as the catheter of the present invention can be used. The second catheter may have other members as long as it has the above members. It is one of the preferable embodiments that the second catheter has a puncture needle. The puncture needle is not particularly limited, and a conventionally known one can be used.

FIG. 7 is a schematic sectional view showing a state in which the puncture needle is removed from an example of the second catheter having the same puncture needle as that in FIG. The second catheter 50 'has a shaft portion 58' having a first lumen 52 ', a second lumen 54', an expander 56 'and a puncture needle. The puncture needle is not shown in FIG. 7 because it has been removed. The first lumen 52 'and the second lumen 54' are
The proximal portion of the shaft portion 58 'is connected to an extracorporeal circulation circuit 78 described later. In FIG. 7, the first lumen 52 ′ is connected to the blood return circuit 82 of the extracorporeal circulation circuit 78, and the second lumen 54 ′ is connected to the blood return circuit 80 of the extracorporeal circulation circuit 78.

In the second catheter 50 ', when the outer cylinder 58'a of the shaft portion 58' is fixed, the inner cylinder 5 '
8'b can slide in the direction of the arrow in FIG. 7 (a). In FIG. 7A, the shaft portion 58 '
The outer cylinder 58'a has the expansion body 56 'housed therein. The first lumen 52 'formed between the outer cylinder 58'a and the inner cylinder 58'b is closed at its distal end side by an expansion body 56'. When the inner cylinder 58′b of the shaft portion 58 ′ is slid from this state, as shown in FIG. 7 (b),
At the distal portion of the shaft portion 58 ', at the same time as the expansion body 56' is exposed to the outside, the expansion body 56 'and the outer cylinder 58'a are separated from each other, and an external opening 60' is formed in the first lumen 52 '. It When the second catheter 50 'is used, puncture is performed in a state in which the expansion body 56' as shown in FIG. 7 (a) is stored, and the expansion body 56 'as shown in FIG. 7 (b) is exposed. Blood is collected and returned in the state. In the present invention, like the second catheter 50 'described above, the external opening of the first lumen may be formed by sliding the shaft portion.

In the method for controlling a catheter with an expandable body according to the third and fourth aspects of the present invention, the second catheter 5
0 is used by inserting the distal portion into a blood vessel. Figure 8
It is explanatory drawing of an example of the control method of the catheter with an expansion body of the 3rd aspect of this invention. In a third aspect of the invention, as shown in FIG. 8, the distal portion of the catheter 50 has a distal end 66 which is oriented toward the blood vessel 2 such that the distal end 66 faces upstream of the blood flow.
Inserted in. In this case, the blood vessel 2 is preferably an artery.

Although not shown, the first lumen 52 is connected to the blood return circuit of the extracorporeal circulation circuit and the second lumen 54 is connected to the blood collection circuit of the extracorporeal circulation circuit at the proximal portion of the shaft portion.

As shown in FIG. 8 (a), when blood is drawn from the blood vessel 2 through the external opening 62 of the second lumen 54, the expander 56 is kept in a contracted state. Next, FIG.
As shown in (b), when returning blood to the blood vessel 2 through the external opening 60 of the first lumen 52, the expansion body 56 is brought into an expanded state. When the expander 56 is in the expanded state, the blood that has passed through the extracorporeal circulation circuit does not backflow in the upstream direction or stay in the vicinity of the external opening 60 of the first lumen 52 when returning blood. , Immediately downstream. Then, as shown in FIG. 8A, when blood is drawn from the blood vessel 2 through the external opening 62 of the second lumen 54, the expandable body 56 is brought into a contracted state again. At this point, the returned blood has already flowed to the downstream side, so the blood that has flowed from the upstream side and has not passed through the extracorporeal circulation circuit can be opened 6
Blood can be collected from 2. Therefore, according to the method for controlling a catheter with a dilator according to the third aspect of the present invention, blood can efficiently pass through the extracorporeal circulation circuit.

FIG. 9 is an explanatory view of an example of a method for controlling the catheter with an expandable body according to the fourth aspect of the present invention. In the fourth aspect of the invention, as shown in FIG. 9, the distal portion of the catheter 50 is inserted into the blood vessel 4 with the distal end 66 pointing downstream of the blood flow. In this case, the blood vessel 4 is
It is preferably a vein.

Although not shown, the first lumen 52 is connected to the blood collecting circuit of the extracorporeal circulation circuit and the second lumen 54 is connected to the blood returning circuit of the extracorporeal circulation circuit in the proximal portion of the shaft portion.

As shown in FIG. 9A, when the blood is collected from the blood vessel 4 through the external opening 60 of the first lumen 52, the expander 56 is kept in the expanded state. By placing the expandable body 56 in the expanded state, blood is blocked at the upstream side of the expandable body 56, and blood can be easily collected even if the blood vessel 4 is a blood vessel having a weak blood flow such as a vein. Next, as shown in FIG. 9B, when returning blood to the blood vessel 4 through the external opening 62 of the second lumen 54, the expandable body 14 is brought into a contracted state. Next, as shown in FIG. 9A, when blood is collected from the blood vessel 4 through the external opening 60 of the first lumen 52, the expandable body 14 is brought into the expanded state again. At this point in time, the returned blood has already flowed to the downstream side, so blood that has flowed from the upstream side and has not passed through the extracorporeal circulation circuit can be collected through the external opening 60. Therefore, according to the method for controlling a catheter with a dilator according to the fourth aspect of the present invention, blood can be efficiently collected even in a blood vessel having a weak blood flow, and the blood can be efficiently passed through the extracorporeal circulation circuit. be able to.

In the third and fourth aspects of the present invention, blood collection and blood return are performed intermittently. When blood sampling and blood returning are performed intermittently, the inner wall of the blood vessel does not continue to be pressed by the balloon, so that the cells on the inner wall are not supplied with nutrients, and the hematoma due to thrombus formation and damage to the blood vessel wall is not present. There are no problems such as formation and blood vessel obstruction. The cycle of repeating blood collection and blood return is not particularly limited, but it is preferable that both blood collection and blood return be 3 to 5 seconds.

In the third and fourth aspects of the present invention, as described above, blood collection and blood return may be performed in conjunction with contraction and expansion of the expansion body 56, and the means therefor is not particularly limited. It is preferable to use the blood collection control device of the sixth aspect of the present invention described below.

FIG. 10 is an explanatory diagram of an example of a blood processing system using the blood collection control device according to the sixth aspect of the present invention.
In FIG. 10, the second catheter 50 has a distal end 66.
Are inserted into the blood vessel 2 so as to face upstream of the blood flow. Further, the second catheter 50 has an expansion body expanding / contracting means 86 for expanding and contracting the expansion body 56 on the proximal end side. The expansion body expansion / contraction unit 86 is not particularly limited, and the same expansion unit expansion / contraction unit 46 can be used. In the case of the illustrated example, the expansion body expanding / contracting means 86 introduces a fluid into the expansion body 56 through the fluid supply pipe 64 to bring the expansion body 56 into an expanded state, and also discharges the fluid from the inside of the expansion body 56 to expand it. The body 56 is contracted.

The second catheter 50 has a blood collecting circuit 80 and a blood returning circuit 82 in the proximal portion of the shaft portion 58.
Is connected to an extracorporeal circulation circuit 78 having a. Figure 10
The second lumen 54 is connected to the blood collection circuit 80 of the extracorporeal circuit 78 when the second catheter 50 is inserted into a blood vessel with the distal end 66 facing upstream of the blood flow, as shown in FIG. The first lumen 52 is connected to the blood return circuit 82 of the extracorporeal circulation circuit 78. Although not shown, when the second catheter 50 is inserted into the blood vessel so that the distal end 66 faces the downstream of the blood flow, the first lumen 52 is connected to the blood collecting circuit 80 of the extracorporeal circulation circuit 78. The second lumen 54 is connected to the blood return circuit 82 of the extracorporeal circulation circuit 78. Extracorporeal circulation circuit 7
A blood processor 85 is provided between the blood collecting circuit 80 and the blood returning circuit 82.

In the illustrated example, the blood sampling circuit 80 is provided with blood circulation means 81 for circulating blood in the extracorporeal circulation circuit 78. The blood circulation means 81 is not particularly limited, and the same one as the blood circulation means 41 can be used.

The extracorporeal circulation circuit 78 has a flow path opening / closing means 84. The flow path opening / closing means 84 is not particularly limited as long as it allows blood to flow into the blood collecting circuit 80 when collecting blood from the blood vessel 2 and allows blood to flow out from the blood returning circuit 82 when returning blood to the blood vessel 2. Not, the flow path opening / closing means 4
The same thing as 4 can be used. In the illustrated example, the blood collecting circuit 80 and the blood returning circuit 82 are provided with flow path opening / closing means 84a and 84b, respectively. The flow path opening / closing means 84a and 84b can take an open state and a closed state, respectively, the flow path opening / closing means 84a is open (the blood collecting circuit 80 is open), and the flow path opening / closing means 84b.
Is closed (the blood return circuit 82 is closed),
When blood is collected, the flow path opening / closing means 84a is closed (the blood collection circuit 80 is closed), and the flow path opening / closing means 84b is open (the blood return circuit 82 is open), blood is returned. .

Blood collection control device 70 of the sixth aspect of the present invention
Has a flow path control means 72, an expansion body control means 74, and an operation control means 76. The flow path control means 72 controls the flow path opening / closing means 84a and 84b of the extracorporeal circulation circuit 78 to open or close each of them. The expansion body control means 74 is the expansion body expansion / contraction means 8 of the catheter 10 of the present invention.
6 to control the fluid supply pipe 20 from the expansion body expansion / contraction means 86.
The fluid is introduced into the expansion body 14 through the to expand the expansion body 14 or the fluid is discharged from the inside of the expansion body 14 to the expansion body expanding / contracting means 86 to contract the expansion body 14.
The operation control means 76 controls the flow path control means 72 and the expansion body control means 74 in association with each other.

In the blood collection control device of the sixth aspect of the present invention, the catheter used is the second catheter 50,
And, the extracorporeal circulation circuit used is the extracorporeal circulation circuit 78 in which the blood collection circuit and the blood return circuit are separately connected to different lumens of the catheter, but is different from the blood collection control device of the fifth aspect of the present invention. Its action is essentially the same.
However, the blood collecting circuit 80 is used for the blood collecting circuit 40, the blood circulating means 81 is used for the blood circulating means 41, and the blood returning circuit 82 is used for the blood returning circuit 4.
2, the flow path opening / closing means 84 (84a and 84b) is connected to the flow path opening / closing means 44 (44a and 44b), and the blood treatment device 8
5 corresponds to the blood processing unit 45, and the expansion body expansion / contraction means 86 corresponds to the expansion body expansion / contraction means 46, respectively.

That is, the operations of the flow path control means 72, the expansion body control means 74 and the operation control means 76 are performed by the flow path control means 3
2. The operation is the same as that of the expansion body control means 34 and the motion control means 36. That is, at the time of collecting blood, the operation control means 76 causes the flow path control means 72 to drive the flow path opening / closing means 84a and 84b to open the blood collection circuit 80 and close the blood return circuit 82. As a result, the extracorporeal circulation circuit 78 is brought into a blood collecting state, and in conjunction with this, the expansion body control means 74 drives the expansion body expansion / contraction means 86 to bring the expansion body 56 into a contracted state. On the other hand, at the time of returning blood, the operation control means 76 causes the flow path control means 72 to open the flow path opening / closing means 8.
4a and 84b are driven to close the blood collection circuit 80 and open the blood return circuit 82 to bring the extracorporeal circulation circuit 78 into the blood return state, and in conjunction with this, control of the dilated body The expansion body expansion / contraction means 86 is driven by the means 74 to bring the expansion body 56 into the expanded state.

Therefore, in the blood collection control device of the sixth aspect of the present invention, when the distal end 66 is inserted into the blood vessel 2 so as to face the upstream of the blood flow, the flow path control means 7 is provided.
2 and the extension body control means 74 and the operation control means 76,
By controlling the blood collecting circuit 80 and the blood returning circuit 82, and the dilator 56, the method for controlling the catheter with the dilator according to the third aspect of the present invention is realized.

Although not shown, in contrast to FIG. 10, the blood vessel 4 is arranged so that the distal end 22 faces the downstream of the blood flow.
When it is inserted into the
Controls the flow path control means 72 in the same manner as in the case of FIG. 10, while controlling the expansion body control means 74 in the opposite manner to the case of FIG. That is, the operation control means 76 drives the expansion body expansion / contraction means 76 at the time of blood collection, introduces the fluid into the expansion body 56 through the fluid supply tube 64 to bring the expansion body 56 into an expanded state, and at the time of blood return. By driving the expansion body expansion / contraction means 76, the fluid is discharged from the inside of the expansion body 56 through the fluid supply pipe 64 to bring the expansion body 56 into a contracted state.

That is, in the blood collection control device according to the sixth aspect of the present invention, the blood vessel 4 is arranged so that the distal end 66 faces the downstream of the blood flow.
When inserted into the catheter, the flow path control means 72, the expansion body control means 74, and the operation control means 76 realize the method for controlling the catheter with an expansion body according to the fourth aspect of the present invention.

In FIG. 10, the flow path control means 72, the expansion body control means 74 and the operation control means 76 of the blood collection control device 70 of the fifth aspect of the present invention are shown as individual blocks, but these are shown. , May be integrally configured.
Further, in the blood collection control device of the fifth aspect of the present invention, the individual means may be configured by hardware,
It may be configured by software or may be a combination of both.

For example, as the flow path control means 72 constituted by hardware, there is a solenoid which has a magnetic force when energized and can open and close the flow path opening / closing means 84a and 84b. As the mechanism of the flow path control means 72 and the flow path opening / closing means 84,
For example, the mechanism described in Japanese Patent Application Laid-Open No. 7-80063 can be used.

Although the method for controlling the catheter with the expandable body, the blood collection control device, and the catheter with the expandable body according to the present invention have been described above based on the preferred embodiments shown in the accompanying drawings, the present invention is not limited thereto. Absent. For example, the configuration of each unit can be replaced with any configuration capable of exhibiting the same function.

[0074]

According to the method for controlling a catheter with a dilator according to the first to fourth aspects of the present invention, a catheter is inserted from one location of a blood vessel, and a blood collecting circuit and a blood returning circuit for extracorporeal circulation are provided. In the forming method, blood can be efficiently passed through the extracorporeal circulation circuit. In addition, various troubles caused by local compression for a long time are not caused.
The blood collection control devices of the fifth and sixth aspects of the present invention are suitably used for the method for controlling a catheter with an expandable body of the first to fourth aspects of the present invention. The catheter with an expandable body according to the seventh aspect of the present invention is suitably used for the method for controlling the catheter with an expandable body according to the first and second aspects of the present invention.

[Brief description of drawings]

FIG. 1 is a schematic view showing an example of a distal portion of a catheter of the present invention.

FIG. 2 is a schematic sectional view showing an example of a catheter of the present invention having a puncture needle. (A) shows a state in which the expansion body 14 'is housed in the outer cylinder 16'a of the shaft portion 16',
(B) shows a state in which the expansion body 14 'is exposed to the outside.

FIG. 3 is an explanatory diagram of an example of a method of controlling the catheter with an expandable body according to the first aspect of the present invention. (A) shows the time of blood collection, (b) shows the time of blood return.

FIG. 4 is an explanatory diagram showing an example of a method for controlling the catheter with an expandable body according to the second aspect of the present invention. (A) shows the time of blood collection, (b) shows the time of blood return.

FIG. 5 is an explanatory diagram of an example of a blood processing system using the blood collection control device according to the fifth aspect of the present invention.

FIG. 6 is a schematic view showing an example of a distal portion of a second catheter.

FIG. 7 is a schematic cross-sectional view showing a state in which a puncture needle is removed from an example of a second catheter having a puncture needle having the same shape as in FIG. (A) shows a state in which the expansion body 56 'is housed in the outer cylinder 58'a of the shaft portion 58', and (b) shows a state in which the expansion body 56 'is exposed to the outside.

FIG. 8 is an explanatory diagram of an example of a method of controlling the catheter with an expandable body according to the third aspect of the present invention. (A) shows the time of blood collection, (b) shows the time of blood return.

FIG. 9 is an explanatory diagram showing an example of a method of controlling the catheter with an expandable body according to the fourth aspect of the present invention. (A) shows the time of blood collection, (b) shows the time of blood return.

FIG. 10 is an explanatory diagram of an example of a blood processing system using the blood collection control device according to the sixth aspect of the present invention.

[Explanation of symbols]

Two or four blood vessels 10, 10'Catheter of the present invention 12,12 'lumen 14,14 ', 56,56' Expanded body 15 'puncture needle 16, 16 ', 58, 58' Shaft part 16'a, 56'a outer cylinder 16'b, 56'b inner cylinder 18, 18 ', 60, 60', 62 External opening 20, 64 Fluid supply pipe 22, 66 distal end 30, 70 Blood collection control device 32, 72 flow path control means 34,74 Extension body control means 36,76 Operation control means 38, 78 Extracorporeal circulation circuit 40, 80 blood sampling circuit 41, 81 Blood circulation means 42, 82 Blood return circuit 43 Confluence part 44, 84 flow path opening / closing means 45,85 blood processor 46,86 Expansion body expansion / contraction means 50, 50 'second catheter 52, 52 'First lumen 54, 54 'Second lumen

   ─────────────────────────────────────────────────── ─── Continued front page    F-term (reference) 4C077 AA05 AA12 BB01 BB02 DD20                       DD25 FF01 KK11 LL01 NN14                       PP08 PP12 PP14                 4C167 AA06 BB02 BB09 BB26 BB33                       BB38 BB40 CC08 CC29 DD03                       GG36 GG37 GG42

Claims (7)

[Claims] 1. A shaft portion having a lumen and an expander capable of being in a contracted state and an expanded state, the lumen having an external opening at a distal portion of the shaft portion, and the shaft portion. A catheter with an expandable body, which is connected to an extracorporeal circulation circuit having a blood collecting circuit and a blood returning circuit at a proximal portion thereof, and wherein the expandable body is present at a distal end side of the external opening at a distal portion of the shaft portion. A method for controlling a catheter with an expandable body in the case where the distal end is inserted into a blood vessel so that the distal end faces upstream of blood flow, and blood sampling and blood return are performed intermittently, A method for controlling a catheter with an expandable body, wherein the expandable body is in a contracted state when blood is collected from a blood vessel, and the expandable body is in an expanded state when blood is returned to the blood vessel. 2. A shaft portion having a lumen and an expander capable of being in a contracted state and an expanded state, the lumen having an external opening at a distal portion of the shaft portion, and the shaft portion. A catheter with an expandable body connected to an extracorporeal circulation circuit having a blood collecting circuit and a blood returning circuit at a proximal portion thereof, wherein the expandable body is present at a distal end side of the external opening at a distal portion of the shaft portion, A method for controlling a catheter with an expandable body, wherein the distal end is inserted into a blood vessel so that the distal end faces downstream of the blood flow, and blood sampling and blood return are performed intermittently. A method for controlling a catheter with an expandable body, wherein the expandable body is in an expanded state when blood is collected from the blood vessel, and the expandable body is in a contracted state when returning blood to the blood vessel. 3. A shaft portion having a first lumen, a second lumen, and an expansion body capable of being in a contracted state and an expanded state, wherein the first lumen has an external opening at a distal portion of the shaft portion. And is connected to the blood returning circuit of an extracorporeal circulation circuit having a blood collecting circuit and a blood returning circuit in the proximal portion of the shaft portion, and the expansion body is the external opening in the distal portion of the shaft portion. Exists on the distal end side,
The second lumen has an external opening on the distal end side of the expansion body at the distal portion of the shaft portion, and is connected to the blood sampling circuit of the extracorporeal circulation circuit at the proximal portion of the shaft portion. A method for controlling a catheter with an expandable body in the case where the distal portion of the catheter with an expandable body is inserted into a blood vessel so that the distal end faces upstream of blood flow, and blood sampling and blood return are performed intermittently A method for controlling a catheter with an expandable body, wherein the expandable body is in a contracted state when blood is collected from the blood vessel, and the expandable body is in an expanded state when blood is returned to the blood vessel. 4. A shaft portion having a first lumen, a second lumen, and an expansion body capable of being in a contracted state and an expanded state, the first lumen having an external opening at a distal portion of the shaft portion. And is connected to the blood collection circuit of an extracorporeal circulation circuit having a blood collection circuit and a blood return circuit at the proximal portion of the shaft portion, and the expansion body is located at the distal portion of the shaft portion from the external opening. Present on the distal end side,
The second lumen has an external opening at the distal portion of the shaft portion on the distal end side of the expansion body, and is connected to the blood return circuit of the extracorporeal circulation circuit at the proximal portion of the shaft portion. Control of a catheter with a dilator, by inserting the distal portion into a blood vessel so that the distal end faces the downstream of the blood flow, and performing blood collection and blood return intermittently A method for controlling a catheter with a dilator, wherein the dilator is in an expanded state when blood is collected from the blood vessel, and the dilator is in a contracted state when blood is returned to the blood vessel. 5. An extracorporeal circulation circuit having a blood sampling circuit and a blood returning circuit, a lumen having a lumen, and a shaft having an expander capable of being in a contracted state and an expanded state, the lumen being a distal portion of the shaft. Has an external opening at the proximal portion, and is connected to the extracorporeal circulation circuit at the proximal portion of the shaft portion,
Using the catheter with an expandable body in which the expandable body exists on the distal end side of the external opening at the distal portion of the shaft portion, the distal portion of the catheter with the expandable body is inserted into a blood vessel to collect blood. A blood sampling control device for controlling the extracorporeal circulation circuit and the catheter with a dilator, which is used when intermittently performing blood return and blood return; flow channel control for controlling flow channel opening / closing means of the extracorporeal circulation circuit Means and an expansion body control means for controlling the expansion body expansion / contraction means of the catheter with an expansion body,
The flow path control means and the extension body control means; and an operation control means for controlling the flow path control means; the flow path control means drives the flow path opening / closing means in accordance with a command from the operation control means,
When collecting blood from the blood vessel, blood is allowed to flow into the blood collecting circuit, and when returning to the blood vessel, blood is allowed to flow out from the blood returning circuit; In the case where the distal end is inserted into a blood vessel so that the distal end faces the upstream of the blood flow by driving the expansion body expanding / contracting means, when the blood is collected from the blood vessel, the expansion body is contracted, When the blood is returned to the blood vessel, the expansion body is in the expanded state, and when the distal end is inserted into the blood vessel so as to face the downstream of the blood flow, when the blood is collected from the blood vessel, the expansion body is in the expanded state. And a blood collection control device that brings the expansion body into a contracted state when returning blood to the blood vessel. 6. A shaft part having an extracorporeal circulation circuit having a blood sampling circuit and a blood returning circuit, a first lumen, a second lumen, and an expander capable of being in a contracted state and an expanded state, The first lumen has an external opening at the distal portion of the shaft portion, the expander is at the distal end side of the external opening at the distal portion of the shaft portion, and the second lumen is the shaft portion. In the case of having an external opening at the distal end side of the dilation body at the distal part of, and being inserted into a blood vessel so that the distal end faces upstream of blood flow,
The second lumen is connected to the blood collecting circuit, the first lumen is connected to the blood returning circuit, and the distal end is inserted into a blood vessel so as to face downstream of the blood flow. In the catheter with an expandable body in which the first lumen is connected to the blood collection circuit and the second lumen is connected to the blood return circuit, the distal portion of the catheter with the expandable body is used. A blood sampling control device for controlling the extracorporeal circulation circuit and the catheter with a dilator, which is used when intermittently collecting blood and returning blood by inserting it into a blood vessel; Flow path control means for controlling the means, expansion body control means for controlling the expansion body expansion and contraction means of the catheter with an expansion body,
The flow path control means and the extension body control means; and an operation control means for controlling the flow path control means; the flow path control means drives the flow path opening / closing means in accordance with a command from the operation control means,
When collecting blood from the blood vessel, blood is allowed to flow into the blood collecting circuit, and when returning to the blood vessel, blood is allowed to flow out from the blood returning circuit; In the case where the distal end is inserted into a blood vessel so that the distal end faces the upstream of the blood flow by driving the expansion body expanding / contracting means, when the blood is collected from the blood vessel, the expansion body is contracted, When the blood is returned to the blood vessel, the expansion body is in the expanded state, and when the distal end is inserted into the blood vessel so as to face the downstream of the blood flow, when the blood is collected from the blood vessel, the expansion body is in the expanded state. And a blood collection control device that brings the expansion body into a contracted state when returning blood to the blood vessel. 7. A shaft portion having a lumen and an expander capable of being in a contracted state and an expanded state, the lumen having at least one external opening at a distal portion of the shaft portion, and The proximal portion of the shaft portion is connected to an extracorporeal circulation circuit having a blood collection circuit and a blood return circuit, and the expansion body is distal to all of the at least one external opening in the distal portion of the shaft portion. A catheter with an expandable body that is present and is used by inserting the distal portion into a blood vessel.