JP2002068947A - Oral composition - Google Patents

Abstract

(57) Abstract: A following general formula _{(1) M n + 2 P} n O 3n + 1 (1) ( where, M represents a Na or K, n is an integer of 2 or more.) And one or more linear water-soluble polyphosphates having an average particle size of 50 to 1,0.
An oral composition for removing a colored pellicle, comprising particles having a particle size of 00 μm and a disintegration strength of 10 to 200 g / particle. The composition for oral cavity according to the present invention has an excellent effect of removing colored pellicles.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral composition for removing colored pellicles.

[0002]

2. Description of the Related Art
Various approaches have been considered to whiten teeth colored with tobacco tar or tea astringent. For example, development of abrasives with high cleaning properties, whitening with peroxides, dissolving of coloring matter with solvents such as polyethylene glycol, removal of iron ions and the like with chelating agents, smoothing of tooth surfaces by remineralization, etc. . However, the effect is insufficient except for the method using peroxide, and the method using peroxide has also been pointed out as a problem that organic substances on the enamel surface escape and the acid resistance is reduced. This is a procedure that can only be performed by a dentist.

[0003] From the above, effectively under mild conditions,
In addition, in order to easily keep the teeth white by themselves, it is necessary to efficiently remove the adhered dirt, and development of the composition has been awaited.

[0004]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to meet the above-mentioned demand, and as a result, have found that a linear water-soluble polyphosphate and an average particle size of 50 to 50 are obtained.
1,000 μm, and the collapse strength is 10 to 200 g
It has been found that the combined use of the particles with / particles significantly improves the effect of removing stains (colored pellicles) on the teeth colored by tobacco tar, tea astringent, and the like.

That is, it is known that a linear water-soluble polyphosphate such as sodium pyrophosphate has been conventionally used as a component for removing tooth stains (Japanese Patent Laid-Open No. 9-17 / 1997).
No. 5966, JP-A-10-182389, JP-T-Hei-7-
It is also known to incorporate the above particles into a composition for oral cavity (Japanese Patent Laid-Open No. 1-29).
No. 9211, JP-A-4-243816, JP-T-Hei10-
No. 505843), a linear water-soluble polyphosphate,
Even if each of the above particles is used alone, the colored pellicle removing effect is low, and even if the particles outside the range of the average particle size and the disintegration strength are used, the colored pellicle removing effect is similarly low. Regardless, it has been found that when a linear water-soluble polyphosphate is used in combination with particles having the above specific average particle size and disintegration strength, a remarkable colored pellicle removing effect can be obtained, and the present invention has been accomplished.

Hereinafter, the present invention will be described in more detail.
Linear water soluble polyphosphates for use in the oral compositions of the present invention is represented by the following general formula _{(1) M n + 2 P} n O 3n + 1 (1) ( where, M represents a Na or K , N is an integer of 2 or more.), Wherein sodium or potassium pyrophosphate having a polymerization degree of n = 2, sodium or potassium tripolyphosphate having n = 3, and tetrapolyphosphoric acid having n = 4 Sodium or potassium tetrapolyphosphate,
Examples thereof include sodium metaphosphate and potassium metaphosphate having a high degree of polymerization. One of these can be used alone, or two or more can be used in combination. Among these, sodium pyrophosphate is particularly preferred.

The compounding amount of the above polyphosphate is 0.1 to 10% (mass percentage, hereinafter the same) of the whole composition, especially 1 to 10%.
Preferably, it is 6%. If the amount is too small, an excellent effect of removing colored pellicles cannot be obtained, and if the amount is too large, the taste of the composition may deteriorate.

According to the present invention, the polyphosphate has an average particle size of 50 to 1,000 μm and a collapse strength of 10 to 20 μm.
0 g / particle is used in combination.

In this case, the particles may be formed in a granular form by using or not using a water-insoluble powder with a binder, and particularly, those without a binder are preferred.

Water-insoluble powders include dibasic calcium phosphate, tribasic calcium phosphate, insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, red iron oxide, calcium carbonate, calcium pyrophosphate, zeolite, aluminosilicate, magnesium carbonate,
Zirconosilicate, calcium sulfate, and the like, and mixtures thereof are fisted, and silica is particularly preferred.

As described above, the particles used in the present invention have an average particle size of 50 to 1,000 μm, preferably 100 to 700 μm, and more preferably 200 to 400 μm.
m. Further, the collapse strength is 10 to 200 g /
Pieces, preferably 30 to 100 g / piece, more preferably 5
0 to 80 g / piece. Particles having an average particle size of less than 50 μm and particles having a collapse strength of less than 10 g / piece are:
Excellent colored pellicle removal effect is not obtained, average particle size is larger than 1,000 μm, and disintegration strength is 200 g
Particles higher than / particles cause a foreign body sensation and discomfort in the oral cavity.

The disintegration strength was determined by immersing the particles in water for 60 seconds and then setting the plunger diameter to 10 mm and the compression rate to 10 mm / m.
Maximum stress value per piece when pressurized under conditions of "in" (g)
It is.

The amount of the above particles is 0.1% of the total composition.
It is preferably from 10 to 10%, particularly preferably from 1 to 5%. If the amount is too small, an excellent effect of removing colored pellicles cannot be obtained. If the amount is too large, the feeling in use may be reduced.

The oral composition of the present invention can be prepared and applied as dentifrice such as toothpaste and liquid dentifrice, dental cream, dental whitening pack, mouthwash, dental whitening solution, etc. The product can be blended with ordinary components according to its type. For example, in the case of a dentifrice, an abrasive, a binder, a thickener, a surfactant, a sweetener, a flavor, and the like can be blended in a usual amount.

For example, abrasives include calcium hydrogen phosphate dihydrate, tribasic calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, silicic anhydride, aluminum silicate, insoluble sodium metaphosphate, tertiary phosphorus Magnesium acid, magnesium carbonate,
Calcium sulfate, bentonite, zirconium silicate,
One or more of polymethyl methacrylate, other synthetic resins, and the like may be blended within a range that does not impair the effects of the present invention.

Examples of the binder include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose and hydroxyethylcellulose; alginic acid derivatives such as sodium alginate and propylene glycol alginate; gums such as xanthan gum, chelant gum, tragacanth gum and karaya gum; One or more kinds of synthetic binders such as polyvinyl alcohol, sodium polyacrylate, and carboxyvinyl polymer, and inorganic binders such as silica gel, veegum, and laponite may be blended.

As humectants, glycerin, sorbitol, propylene glycol, polyethylene glycol,
One or more polyhydric alcohols such as xylitol, maltitol and lactitol may be blended.

Examples of the surfactant include an anionic surfactant such as sodium lauryl sulfate, a nonionic surfactant such as decaglyceryl laurate and diethanolamide myristate, and an amphoteric surfactant such as betaine. .

The fragrance component includes menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, cineol, linalool, ethyl linalool, crocodile, thymol, peppermint oil, spearmint oil, wintergreen oil, T-shaped oil, fragrances such as eucalyptus oil can be blended alone or in combination, saccharin sodium,
Sweetening agents such as stevioside, glycyrrhizin, perillartin, thaumatin and the like can be added.

Further, in the present invention, cationic fungicides such as chlorhexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, decanium chloride, phenolic compounds such as triclosan, hinokitiol and biosol, dextranase, mutanase, lysozyme, amylase, protease, lytic enzymes, enzymes such as superoxide dismutase, vitamin E, vitamins such as vitamin B _6, sodium monofluorophosphate, alkali metal monofluorophosphate salts such as potassium monofluorophosphate, Sodium fluoride, fluorides such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid,
One or more known active ingredients such as aluminum chlorohydroxyl allantoin, dihydrocholestanol, glycyrrhizic acids, glycyrrhetinic acid, bisabolol, glycerophosphate, chlorophyll, sodium chloride, and a water-soluble inorganic phosphate compound can be blended.

[0021]

The oral composition according to the present invention has an excellent colored pellicle removing effect.

[0022]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass percentage.

[Comparative Examples 1 to 5, Example 1] Dentifrices containing the components shown in Table 1 were prepared, and the effect of removing colored pellicle from teeth was evaluated by the following method. The results are also shown in Table 1. <Test for removing tooth-colored pellicle> First, the color difference is measured using the color of hydroxyapatite pellets (hereinafter, referred to as HAP) as a reference value (L0). H measured
The AP is saliva treated at 37 ° C. for 30 minutes. 3 minutes later, HAP
Is rinsed with ion-exchanged water, and then water droplets on the HAP are removed. Next, HAP was added to a 0.5% aqueous albumin solution → 3%
Extracted aqueous solution of Japanese tea + 1% coffee + 1% black tea → 0.6
The solution was repeatedly immersed in each aqueous solution of 1% iron ammonium citrate for 1 hour, and this operation was continued for 50 cycles. Remove from coloring solution, dry at room temperature for 1 day, and lightly HAP in running water
Was brushed to remove weakly adhered colored matter, and then air-dried again, and the color difference of the produced colored HAP was measured (L1). A colored HA prepared by applying a dentifrice to a toothbrush
The color difference after the surface of P was brushed 1,000 times was measured (L2), and the effect of removing the colored pellicle was determined by the following equation. Colored pellicle removal effect = (L0-L1)-(L0-L
2)

[0024]

[Table 1] Particle A: average particle diameter 300 μm, collapse strength 60 g / particle, silica particles Particle B: average particle diameter 10 μm, collapse strength 60 g / particle, silica particles Particle C: average particle diameter 300 μm, collapse strength 6 g / particle, silica particles The collapse strength was measured as described below. Disintegration strength measurement method The colored pellicle-removed particles were immersed in water for 60 seconds. After 60 seconds, the particles were taken out of the water, and the maximum stress when the plunger was pressed under the conditions of a diameter of 10 mm and a compression speed of 10 mm / min was measured. .

From the results shown in Table 1, it was confirmed that by using particles having a mean particle size and a disintegration strength within the range of the present invention in combination with a polyphosphate, the colored pellicle of the tooth can be efficiently removed.

Hereinafter, a formulation example is shown. Example 2 Toothpaste Particle A 3.0% Sodium Tripolyphosphate 1.0 Calcium Dihydrogen Phosphate 45.0 Propylene Glycol 3.0 Carboxymethyl Cellulose 1.0 Carrageenan 0.2 Butyl Paraben 0.2 70% Sorbitol 22 0.0 Sodium benzoate 0.2 Sodium monofluorophosphate 0.7 Thickening silica 3 Titanium dioxide 1 Sodium lauryl sulfate 1.0 Fragrance 1.4 Purified water Balance meter 100.0%

Example 3 Toothpaste Particle D 5.0% (Average particle size 400 μm, disintegration strength 100 g / piece, calcium carbonate particles) Sodium pyrophosphate 1.0 Xanthan gum 0.4 Sodium alginate 0.6 Cetylpyridinium chloride 0.2 Aluminum hydroxide 40.0 70% Sorbitol 30.0 Propylene glycol 3.0 Sodium lauryl sulfate 0.8 Myristate diethanolamide 1.0 Saccharin sodium 0.2 Methyl paraben 0.1 Fragrance 1.0 Purified water Balance meter 100 0.0%

Example 4 Liquid Dentifrice Particles A 4.0% Sodium Pyrophosphate 3.0 Sodium Tripolyphosphate 4.0 Xanthan Gum 0.2 Sodium Polyacrylate 0.2 Butylparaben 0.1 70% Sorbitol 43.0 Precipitating silica 15.0 Propylene glycol 2.0 Glycerin 28.0 Sodium benzoate 0.2 Tranexamic acid 0.05 Sodium fluoride 0.21 Sodium lauryl sulfate 1.5 Fragrance 1.0 Purified water Balance meter 100.0%

Example 5 Mouthwash Particle A 1.0% Sodium pyrophosphate 4.0 Ethanol 5.0 Glycerin 10.0 Saccharin sodium 0.1 Polyoxyethylene hydrogenated castor oil 0.1 Sodium benzoate 0.3 Perfume 0.5 Purified water Balance meter 100.0%

Example 6 Mouth Freshener Particle D 3.0% Sodium Tetrapolyphosphate 1.0 Ethanol 30.0 Glycerin 15.0 Saccharin Sodium 0.3 Sucrose Fatty Acid Ester 3.0 Fragrance 1.0 Purified Water Balance 100.0% in total

Example 7 Chewing Gum Particle D 3.0% Sodium Pyrophosphate 1.0 Gum Base 41.0 Citric Acid 2.0 Maltitol 40.0 Glycerin 1.0 Reduced Maltose 10.0 Perfume 1.5 Purified Water Balance total 100.0%

[Example 8] Rayon / polypropylene tooth sticking sheet having the following gel composition as an adhesive layer (applying the sheet as it is to the tooth) Gel composition particles A 4.0% Sodium pyrophosphate 3.0 Sodium Lauryl Sulfate 2.0 Ethanol 8.0 Sorbit 30.0 Hydroxyethyl Cellulose 4.5 Sodium Alginate 2.5 Saccharin Sodium 0.02 Fragrance 1.0 5N Hydrochloric Acid (pH Adjuster) Appropriate Quantity Purified Water Balance Meter 100.0 %

Example 9 Combination of the following toothpaste-like composition and a silicone rubber mouse tray (the toothpaste-like composition is filled and chewed at the time of use) Toothpaste-like composition particles A1.0 % Sodium tripolyphosphate 5.0 Sodium pyrophosphate 5.0 N-lauroylmethyltaurine sodium 1.0 Sorvitol 15.0 Xylitol 10.0 Silicic anhydride 20.0 Xanthan gum 2.0 Carrageenan 0.5 Saccharin sodium 0.1 Fragrance 1 0.0 purified water balance meter 100.0%

Continued on front page F-term (reference) 4C083 AB172 AB222 AB242 AB281 AB282 AB332 AC102 AC122 AC132 AC302 AC312 AC432 AC482 AC622 AC642 AC782 AC852 AC862 AD092 AD212 AD222 AD272 AD282 AD302 AD352 BB21 CC41 DD12 DD22 EE34 EE35

Claims (2)

[Claims] 1. A linear chain represented by the following general formula (1): M _{n + 2} P _n O _{3n + 1} (1) (where M represents Na or K, and n is an integer of 2 or more). Contains one or more of water-soluble polyphosphates in the form of a powder, and has an average particle size of 50 to 1,0.
An oral composition for removing a colored pellicle, comprising particles having a particle size of 00 μm and a disintegration strength of 10 to 200 g / particle. 2. The oral composition according to claim 1, wherein the polyphosphate is sodium pyrophosphate.