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JP2001515039A - アミロイド症を治療するためのホスホノ−カルボキシレート化合物 - Google Patents

アミロイド症を治療するためのホスホノ−カルボキシレート化合物

Info

Publication number
JP2001515039A
JP2001515039A JP2000509424A JP2000509424A JP2001515039A JP 2001515039 A JP2001515039 A JP 2001515039A JP 2000509424 A JP2000509424 A JP 2000509424A JP 2000509424 A JP2000509424 A JP 2000509424A JP 2001515039 A JP2001515039 A JP 2001515039A
Authority
JP
Japan
Prior art keywords
group
compound
hydrogen
therapeutic compound
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000509424A
Other languages
English (en)
Japanese (ja)
Inventor
ウォルター エイ． スザレック
シャンギ コング
グレゴリー アール．ジェイ． サッチャー
ボリス ゴリン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Queens University at Kingston
Original Assignee
Queens University at Kingston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/912,574 external-priority patent/US5869469A/en
Application filed by Queens University at Kingston filed Critical Queens University at Kingston
Publication of JP2001515039A publication Critical patent/JP2001515039A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
    • C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2000509424A 1997-08-18 1998-04-10 アミロイド症を治療するためのホスホノ−カルボキシレート化合物 Withdrawn JP2001515039A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/912,574 1997-08-18
US08/912,574 US5869469A (en) 1997-08-18 1997-08-18 Phosphonocarboxylate compounds for treating amyloidosis
US7444598P 1998-02-11 1998-02-11
US60/074,445 1998-02-11
PCT/IB1998/000967 WO1999008685A1 (fr) 1997-08-18 1998-04-10 Composes de phosphono-carboxylate conçus pour le traitement de l'amylose

Publications (1)

Publication Number Publication Date
JP2001515039A true JP2001515039A (ja) 2001-09-18

Family

ID=26755679

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000509424A Withdrawn JP2001515039A (ja) 1997-08-18 1998-04-10 アミロイド症を治療するためのホスホノ−カルボキシレート化合物

Country Status (6)

Country Link
EP (1) EP1014994A1 (fr)
JP (1) JP2001515039A (fr)
CA (1) CA2300910C (fr)
IL (1) IL134619A0 (fr)
NZ (1) NZ550116A (fr)
WO (1) WO1999008685A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002515429A (ja) * 1998-05-15 2002-05-28 ネウロケム、インク ニューロン細胞死を調節する方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2437899A (en) * 1998-02-11 1999-08-30 Neurochem, Inc. Method for modulating macrophage activation
US6310073B1 (en) 1998-07-28 2001-10-30 Queen's University At Kingston Methods and compositions to treat glycosaminoglycan-associated molecular interactions
DE60042896D1 (de) * 1999-04-28 2009-10-15 Bellus Health Int Ltd Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten
US6562836B1 (en) * 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
CA2747954C (fr) * 1999-12-03 2014-02-25 The Regents Of The University Of California Composes de phosphonate
US6670399B2 (en) 1999-12-23 2003-12-30 Neurochem (International) Limited Compounds and methods for modulating cerebral amyloid angiopathy
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
WO2006085149A2 (fr) 2004-12-22 2006-08-17 Neurochem (International) Limited Methodes et compositions de traitement de maladies liees a l'amyloide
AU2006342958A1 (en) 2005-12-22 2007-11-08 Bellus Health (International) Limited Treatment of renal disorders, diabetic nephropathy and dyslipidemias
SI2089417T1 (sl) 2006-10-12 2015-04-30 Bhi Limited Partnership Metode, spojine, sestavki in vektorji za dostavo 3-amino-1-propansulfonske kisline
US8993542B2 (en) 2008-01-25 2015-03-31 Chimerix Inc. Methods of treating viral infections
AU2011216243B2 (en) 2010-02-12 2015-07-09 Chimerix, Inc. Nucleoside phosphonate salts
EP2563367A4 (fr) 2010-04-26 2013-12-04 Chimerix Inc Méthodes de traitement d'infections rétrovirales et régimes posologiques associés
EP4475846A1 (fr) * 2022-02-11 2024-12-18 Tzerma LLC Procédés de prévention de minéralisation cérébrale ectopique dans la maladie d'alzheimer et les démences

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1144937A (fr) * 1977-12-22 1983-04-19 Dke J.E. Helgstrand Derives aromatiques, composes pharmaceutiques et methode pour combattre les infections a virus
DE3940410A1 (de) * 1989-12-04 1991-06-06 Schering Ag Neue verwendung von nmda-rezeptor-antagonisten
CA2159326C (fr) * 1993-03-29 2000-05-30 Robert Kisilevsky Methode pour le traitement de l'amyloidose
AU6836394A (en) * 1993-06-01 1994-12-20 Cortex Pharmaceuticals, Inc. Use of metabotropic receptor agonists in progressive neurodegenerative deseases
US6043283A (en) * 1996-09-20 2000-03-28 Baylor College Of Medicine Tyramine compounds and their neuronal effects
EP1005348A1 (fr) * 1996-09-27 2000-06-07 Guilford Pharmaceuticals Inc. Compositions de naaladase et methodes de traitement des anomalies du glutamate et de suscitation d'une activite neuronale chez l'animal
SE9604582D0 (sv) * 1996-12-13 1996-12-13 Astra Ab Novel compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002515429A (ja) * 1998-05-15 2002-05-28 ネウロケム、インク ニューロン細胞死を調節する方法

Also Published As

Publication number Publication date
EP1014994A1 (fr) 2000-07-05
NZ550116A (en) 2008-03-28
IL134619A0 (en) 2001-04-30
CA2300910C (fr) 2008-02-26
CA2300910A1 (fr) 1999-02-25
WO1999008685A1 (fr) 1999-02-25

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