JP2001098000A5 - - Google Patents
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- JP2001098000A5 JP2001098000A5 JP1999276652A JP27665299A JP2001098000A5 JP 2001098000 A5 JP2001098000 A5 JP 2001098000A5 JP 1999276652 A JP1999276652 A JP 1999276652A JP 27665299 A JP27665299 A JP 27665299A JP 2001098000 A5 JP2001098000 A5 JP 2001098000A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- acid sequence
- present
- glucagon production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Description
【特許請求の範囲】
【請求項１】 配列表の配列番号１で示されるアミノ酸配列を有するペプチド又は該アミノ酸配列中の１若しくは複数のアミノ酸が置換し若しくは欠失し、若しくは該アミノ酸配列に１若しくは複数のアミノ酸が挿入され若しくは付加されたアミノ酸配列を有するペプチドであってグルカゴン産生促進効果を有するペプチド。
【請求項２】 配列番号１で示されるアミノ酸配列を有するペプチドを有効成分とする請求項１記載のペプチド。
【請求項３】 請求項１又は２記載のペプチドを有効成分として含有する医薬。
【請求項４】 グルカゴン産生促進剤である請求項３記載の医薬。
[Claims]
1. A peptide having an amino acid sequence represented by SEQ ID NO: 1 in the sequence listing, or one or more amino acids in the amino acid sequence are substituted or deleted, or one or more amino acids are inserted into the amino acid sequence. A peptide having an added or added amino acid sequence and having an effect of promoting glucagon production.
2. The peptide according to claim 1, which comprises a peptide having the amino acid sequence represented by SEQ ID NO: 1 as an active ingredient.
3. A pharmaceutical comprising the peptide according to claim 1 as an active ingredient.
4. The medicament according to claim 3, which is a glucagon production promoter.
【０００８】
【発明が解決しようとする課題】
従って、本発明の目的は、従来のものとは作用機序が全く異なる低血糖症治療薬として用いることができる新規な薬剤を提供することである。
[0008]
[Problems to be solved by the invention]
Accordingly, an object of the present invention is to provide a novel drug which can be used as a therapeutic agent for hypoglycemia, which has a completely different mechanism of action from conventional ones.
【０００９】
【課題を解決するための手段】
本願発明者は、鋭意研究の結果、特定のアミノ酸配列を有するペプチドが、優れたグルカゴン産生促進効果を有することを見出し本発明を完成した。
[0009]
[Means for Solving the Problems]
As a result of intensive studies, the present inventors have found that a peptide having a specific amino acid sequence has an excellent glucagon production promoting effect, and have completed the present invention.
すなわち、本発明は、配列表の配列番号１で示されるアミノ酸配列を有するペプチド又は該アミノ酸配列中の１若しくは複数のアミノ酸が置換し若しくは欠失し、若しくは該アミノ酸配列に１若しくは複数のアミノ酸が挿入され若しくは付加されたアミノ酸配列を有するペプチドであってグルカゴン産生促進効果を有するペプチド、及び該ペプチドを有効成分とする、グルカゴン産生促進剤のような医薬を提供する。 That is, the present invention provides a peptide having the amino acid sequence represented by SEQ ID NO: 1 in the sequence listing, or substitution or deletion of one or more amino acids in the amino acid sequence, or one or more amino acids in the amino acid sequence. Provided are a peptide having an inserted or added amino acid sequence and having an effect of promoting glucagon production, and a medicament containing the peptide as an active ingredient, such as a glucagon production promoting agent.
本発明のグルカゴン産生促進剤の有効成分であるペプチドは、市販のペプチド合成機を用いて容易に合成することができる。 The peptide which is an active ingredient of the glucagon production promoter of the present invention can be easily synthesized using a commercially available peptide synthesizer.
【００４８】
【発明の効果】
本発明により、従来のものとは作用機序が全く異なる低血糖症治療薬として用いることができる新規な薬剤が提供された。
[0048]
【The invention's effect】
According to the present invention, there has been provided a novel drug which can be used as a therapeutic agent for hypoglycemia having a completely different mechanism of action from conventional ones.
【００４９】
【配列表】
SEQUENCE LISTING
<110> Sakamoto, Kenji
Nakoshi, Hideo
<120> Novel peptides and medical use thereof
<130> 99617
<160> 1
[0049]
[Sequence list]
SEQUENCE LISTING
<110> Sakamoto, Kenji
Nakoshi, Hideo
<120> Novel peptides and medical use them
<130> 99617
<160> 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27665299A JP2001098000A (en) | 1999-09-29 | 1999-09-29 | New peptide and medicinal use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27665299A JP2001098000A (en) | 1999-09-29 | 1999-09-29 | New peptide and medicinal use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001098000A JP2001098000A (en) | 2001-04-10 |
| JP2001098000A5 true JP2001098000A5 (en) | 2006-11-02 |
Family
ID=17572448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP27665299A Pending JP2001098000A (en) | 1999-09-29 | 1999-09-29 | New peptide and medicinal use thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2001098000A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2003066672A1 (en) * | 2002-02-08 | 2005-06-09 | 坂本 賢二 | peptide |
| EP1849590B1 (en) | 2006-04-29 | 2013-05-15 | Fette GmbH | Press |
-
1999
- 1999-09-29 JP JP27665299A patent/JP2001098000A/en active Pending
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