JP2000273031A - Protection cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic safely usable even by a person of sensitive skin and giving excellent feeling by including a specific sugar-bonded polymer and an acrylic acid-alkyl methacrylate copolymer. SOLUTION: The objective cosmetic contains (A) a sugar-bonded polymer containing N-p-vinylbenzyl-D-cellobionamide, galactosyloxypropyl acrylate, etc., as constituent monomer and produced by bonding a group containing a sugar such as glucose or xylose to a polymer base such as polystyrene, poly(α- methylstyrene), polypropylene, polycarbonate, urethane resin or fluororesin through covalent bond and (B) an acrylic acid-(10-30C)alkyl methacrylate copolymer [e.g. Pemulen TR-1(R)]. The contents of the component A and the component B in the cosmetic are preferably 0.01-10 wt.% each.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic suitable for a person with sensitive skin.

[0002]

2. Description of the Related Art In recent society, various stresses fall on what lives there. For this reason, in modern society, many people are suffering from illness or physical disorder caused by stress. In recent years, even in the cosmetics world, people who are sensitive to various stimuli, so-called sensitive skin, have never experienced before. Is said to be. Since people with such sensitive skin also react sensitively to highly safe ingredients such as surfactants that can be used safely by ordinary people, cosmetics can hardly be used. It is the current situation. For this reason, inconvenience occurs in skin care and the like, and there has been a demand for the development of a cosmetic that can be used with peace of mind by such people. As a means for responding to such a situation, a technique which has been recently discovered includes a method of using a surfactant of an acrylic acid / alkyl methacrylate (C10-30) copolymer and / or a salt thereof as an emulsifier and a thickener. Techniques for reducing the content are mentioned. However, this has a drawback that the slimy feeling may become remarkable when it is contained sufficiently for emulsification, and it has been desired to reduce the content. The reduction of the weight was necessary not only from such a viewpoint but also for further reducing the irritating feeling in the usability.

On the other hand, a sugar-bonded polymer in which a group containing a saccharide in a structural unit is covalently bonded to a polymer substrate has been developed as a moisturizing material for cosmetics (JP-A-6-122609 and JP-A-5-43418). In recent years, it has been widely used in skin care cosmetics, etc., but it can be used with acrylic acid / alkyl methacrylate (C10-30) copolymers, and with such a combination, even people with sensitive skin can use it safely. It has not been known at all that it is possible to provide a cosmetic composition which is easy to use and has excellent usability.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and it is an object of the present invention to provide a cosmetic composition which can be used safely by people with sensitive skin and which has an excellent feeling in use. .

[0005]

SUMMARY OF THE INVENTION In view of such circumstances, the present inventors have made intensive research efforts in search of cosmetics that can be used safely by even people with sensitive skin and have excellent usability. 1) A saccharide-bonded polymer in which a group containing a saccharide as a constituent unit is covalently bonded to a polymer substrate, and 2) an acrylic acid / alkyl methacrylate (C10 to 30) copolymer and / or a salt thereof, Finding such properties in cosmetics,
The invention has been completed. Hereinafter, the present invention will be described in detail focusing on embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION (1) Sugar-bonded polymer in which a saccharide-containing group is covalently bonded to a polymer base which is an essential component of the cosmetic of the present invention. It is characterized by containing a sugar-binding polymer in which the group contained in the structural unit is covalently bonded. These sugar-binding polymers are compounds in which a group containing a sugar is covalently bonded to the base of the polymer, and are so-called pendant type polymers. It is already known that such a sugar-binding polymer is excellent in sustaining the excellent moisturizing action of sugar on the skin, and has an action of adhering between keratinocytes. As the polymer substrate of the sugar-bonded polymer, any generally used polymer can be used without particular limitation. Examples thereof include polystyrene, poly (-α-methylstyrene), polyvinyl chloride, and polyvinyl alcohol. , Polyacylvinyl, polyalkylvinyl, polyamide, polyester, polypropylene, polycarbonate, urethane resin, fluorine resin, silicone and acrylic resin. Among them, particularly preferred polymers are styrene resins such as polystyrene and poly (-α-methylstyrene) and polyacrylic acid, polymethacrylic acid,
Acrylic resins such as polyalkyl acid esters and polymethacrylic acid esters. Furthermore, the saccharide moiety of a group containing a saccharide structure covalently bonded to these polymers can be used without any particular limitation as long as the saccharide is present as a component of a normal living body. For example, glucose, arabinose, xylose, galactose, mannose, fructose, glucosamine, sialic acid and / or a salt thereof, muramic acid and / or a salt thereof,
Glucuronic acid and / or a salt thereof, galacturonic acid and / or
Or salts thereof, derivatives thereof, and the like. here,
A derivative is a derivative that can be easily derived based on the hydroxyl group of a sugar, and examples thereof include an acylated product such as an acetylated product, an alkylated product such as methyl ether, a sulfonic acid ester and / or a salt thereof. It can be preferably exemplified. These can be easily derived according to a conventional method. In addition, such a sugar moiety may be a plurality of kinds in one polymer, or may be only one kind. The sugar moiety can be directly covalently bonded to the polymer substrate, or may be covalently bonded via an intermediary group such as an oxy (C1-4) alkyl group which does not impair the effects of the present invention. Preferred constituent monomers of such a sugar-binding polymer include Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactonamide, Np-vinylbenzyl-D-maltonamide , N
-P-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, and a polymer containing one or more selected from these as a constituent monomer. Preferred polymers. Here, as the polymer of the present invention, in addition to these monomers having a group having a sugar structure, a monomer which is usually used in a polymer may be contained as a constituent monomer, and a copolymer may be used. It is also possible to use a polymer or copolymer of only a monomer having a saccharide structure, but more preferable is a polymer or copolymer of only a monomer having a saccharide structure. That is, in other words, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide,
-P-vinylbenzyl-D-maltonamide, Np-
One or more homopolymers or copolymers selected from vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, and mannosyloxyethyl methacrylate are particularly preferred. Among them, Np-vinylbenzyl-D-lactone amide homopolymer (PVLA)
And glucosyloxyethyl methacrylate homopolymer (PGEMA) are particularly preferred. These polymers are
The above-mentioned monomer alone or two or more kinds thereof may be easily added by adding a monomer having no arbitrary sugar structure in the presence of a polymerization initiator such as ammonium persulfate or azobisisobutyronitrile. Can be obtained. For a detailed production method of such a polymer, see JP-A-6-122.
609 and JP-A-5-43418.
In the cosmetic of the present invention, a group containing a saccharide as a constituent unit is covalently bonded to the polymer substrate obtained in this manner.
One or more selected from sugar-binding polymers are contained as essential components. These components, in the cosmetic of the present invention, exhibit an excellent moisturizing effect on the skin, and at the same time, exhibit an effect of suppressing the skin from causing an undesired reaction such as an allergic reaction. Furthermore, it has the effect of reducing the amount of an emulsifier, an acrylic acid / alkyl methacrylate (C10-30) copolymer and / or a salt thereof, and suppressing this slimy feeling. The content of these sugar-binding polymers in the cosmetic of the present invention is preferably 0.01 to 10% by weight, more preferably 0.05 to 1% by weight. This is because if the amount is too small, the above-mentioned effect may not be exhibited, and if the amount is too large, such an effect may reach a peak and a dosage form may be restricted.

(2) Acrylic acid / alkyl methacrylate (C10-30) copolymer and / or a salt thereof, which are essential components of the cosmetic of the present invention, are made of acrylic acid / methacrylic acid (C10
~ 30) It is characterized by containing a copolymer and / or a salt thereof. This can also be manufactured according to a conventional method. For example, a salt of methacrylic acid such as sodium methacrylate and a long-chain alkyl sodium alkoxide may be condensed to prepare a long-chain alkyl methacrylate, and this may be polymerized with acrylic acid. Like this
Adjusted ones can be used, but such copolymers are already commercially available and can also be used. Preferable examples of such commercially available products include Pemulen TR-1 and Pemulen TR-2, which are commercially available from Goodrich. These may contain only one kind, or may contain two or more kinds in combination. This emulsifies a system with little or no surfactant in the cosmetic of the present invention,
It has an effect of stabilizing the emulsification and preventing a person with sensitive skin from being stimulated. In the cosmetic of the present invention, the preferable content of the acrylic acid / alkyl methacrylate (C10-30) copolymer and / or a salt thereof is, in total,
0.01 to 10% by weight, more preferably 0.0 to 10% by weight.
5 to 5% by weight. If the amount is too large, the feeling of use or the stability of the system itself may be impaired. If the amount is too small, the above-mentioned effects may not be exhibited. In addition, as the salt, those usually used in cosmetics can be used without particular limitation, for example, alkali metal salts such as potassium and sodium, magnesium salts, and alkaline earth metal salts such as calcium. , Ammonium salts, organic amine salts such as triethanolamine and triethylamine, and basic amino acid salts such as lysine and arginine.

(3) Cosmetic of the Present Invention The cosmetic of the present invention is not particularly limited as long as it is a cosmetic that is usually used in the market, for example, basic cosmetics,
It can be applied to make-up cosmetics, hair cosmetics, cleansing cosmetics, etc., but preferred are skin cosmetics used by people with sensitive skin. The high safety attributed to the sugar-binding polymer of the cosmetic of the present invention can be used even by a person who is sensitive to an acrylic acid / alkyl methacrylate (C10-30) copolymer. Demonstrate.
Therefore, it is particularly preferable to apply the cosmetic of the present invention to cosmetics for sensitive skin. In the cosmetic of the present invention, in addition to the above-mentioned essential components, optional components usually used in cosmetics can be used as long as the effects of the cosmetic of the present invention are not impaired. Examples of such optional components include hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, and stearic acid. Fatty acids such as oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, ethanol, carbopol, etc. Viscous agent, preservative, UV absorber,
Preferred examples include antioxidants, dyes, and powders. The cosmetic of the present invention can be produced by treating these components according to a conventional method.

[0009]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited to these examples.

<Examples 1 and 2> Cosmetics of the present invention were prepared according to the following formulation. That is, the components (a), (b) and (c) are each heated to 80 ° C., (b) is neutralized by adding (b) to (a) and emulsified by adding (c) while gradually stirring the mixture. Then, an emulsion, which is the cosmetic of the present invention, was obtained. In addition, PGEMA is all Pemulen T
Comparative Example 1 substituted with R-2 and Pemulen TR-2 were all P
Comparative Example 2 in which GEMA was substituted was also prepared, but Comparative Example 2 was not emulsified and a sample could not be prepared. Their stability (40 ° C., 10 days) was also investigated. I Pemulen TR-2 * PGEMA (molecular weight 100,000) * Glycerin 3 parts by weight 1,3-butanediol 5 parts by weight Methyl paraben 0.1 parts by weight Water 50 parts by weight b Potassium hydroxide * Water * 5 parts by weight glycerin monooleyl Ether 2 parts by weight Cetanol 3 parts by weight * Details (parts by weight) are shown in Table 1.

[0011]

[Table 1]

<Example 3> With respect to the emulsions of Examples 1 and 2 and Comparative Example 1, the feeling of use was evaluated by an expert. The evaluation items were moist feeling and non-stickiness, and the evaluation criteria were ++: very good, +: good, ±: slightly good,-: bad. Table 2 shows the results. From this, it can be seen that the emulsions of Examples 1 and 2, which are the cosmetics of the present invention, are excellent in moist feeling, but have an excellent feeling of use without stickiness.

[0013]

[Table 2]

Example 4 A skin irritation test was performed on the emulsions of Examples 1 and 2 and Comparative Example 1 using guinea pig damaged skin. That is, the back of a group of six Hartley white guinea pigs (male, 300 to 400 g) was shaved,
After stripping the gum tape, the sample was closed patched for 48 hours. One hour after removal of the patch, the skin response was determined according to Draize criteria. That is, ++: reaction with edema, +: reaction with clear erythema, ±: reaction with weak erythema,-: no reaction. Table 3 shows the results. This indicates that the emulsion of the cosmetic of the present invention is extremely safe.

[0015]

[Table 3]

<Example 5> The samples of Examples 1 and 2 and Comparative Example 1 were examined for their allergy-inducing effect.
That is, 50 guinea pigs were subjected to four intradermal injections (in the presence of Freund's complete adjuvant) and two 48-hour closed patch treatments with a 0.5% aqueous formalin solution according to the maximization test method.
After sensitization and a 2-week rest period, the backs of seven animals that were positive with a closed patch of 0.05% aqueous formalin for 24 hours were shaved and four 2 cm × 2 cm sites were formed. 0.05 ml of sample and water in each part
Was administered. Thereafter, the entire site was covered with a patch bandage impregnated with a 0.1% formalin aqueous solution and closed for 24 hours. One hour after removal of the patch, the skin response was determined by Draise criteria. Table 4 shows the results. This indicates that the cosmetic of the present invention has an allergy-inducing effect. This indicates that the cosmetic of the present invention is suitable for applying to people who are sensitive to external stimuli such as atopic dermatitis.

[0017]

[Table 4]

<Examples 6 and 7> Cosmetics of the present invention were prepared according to the following formulation. That is, the components (a), (b) and (c) are each heated to 80 ° C., (b) is neutralized by adding (b) to (a) and emulsified by adding (c) while gradually stirring the mixture. Then, an emulsion, which is the cosmetic of the present invention, was obtained. In addition, all PVLA is Pemren TR
Comparative Example 1 and Pemulen TR-2 in which
Although Comparative Example 3 in which LA was substituted was also prepared, Comparative Example 3 was not emulsified and a sample could not be prepared. Their stability (40 ° C., 10 days) was also investigated. I Pemulen TR-2 ** PVLA (Molecular weight 20,000) ** Glycerin 3 parts by weight 1,3-butanediol 5 parts by weight Methylparaben 0.1 parts by weight Water 50 parts by weight b Potassium hydroxide ** Water ** HA Squalane 5 parts by weight Parts glycerin monooleyl ether 2 parts by weight Cetanol 3 parts by weight ** Details of contents (parts by weight) are shown in Table 5. The results evaluated in the same manner as in Example 3 are also shown. It can be seen that PVLA has the same effect as PGEMA.

[0019]

[Table 5]

Example 8 A cosmetic of the present invention was prepared according to the following formulation. That is, the components (a), (b) and (c) are each heated to 80 ° C., (b) is neutralized by adding (b) to (a) and emulsified by adding (c) while gradually stirring the mixture, homogenizing the particles with a homogenizer, and then stirring and cooling. Then, an emulsion, which is the cosmetic of the present invention, was obtained. Their stability (40 ° C, 10 days)
I found no problem at all. Further, the moist feeling and the sticky feeling were also ++. I Pemulen TR-1 0.2 parts by weight PVLA (molecular weight 20,000) 0.1 part by weight Glycerin 3 parts by weight 1,3-butanediol 5 parts by weight Methylparaben 0.1 parts by weight Water 50 parts by weight potassium hydroxide 0.2 Parts by weight water 31.4 parts by weight squalane 5 parts by weight glycerin monooleyl ether 2 parts by weight cetanol 3 parts by weight

Example 9 A cosmetic of the present invention was prepared according to the following formulation. That is, the components (a), (b) and (c) are each heated to 80 ° C., (b) is neutralized by adding (b) to (a) and emulsified by adding (c) while gradually stirring the mixture, homogenizing the particles with a homogenizer, and then stirring and cooling. Then, an emulsion, which is the cosmetic of the present invention, was obtained. Their stability (40 ° C, 10 days)
I found no problem at all. Further, the moist feeling and the sticky feeling were also ++. I Pemulen TR-1 0.2 parts by weight PGEMA (molecular weight 100,000) 0.1 part by weight Glycerin 3 parts by weight 1,3-butanediol 5 parts by weight Methylparaben 0.1 parts by weight Water 50 parts by weight potassium hydroxide 0.2 Parts by weight water 31.4 parts by weight squalane 5 parts by weight glycerin monooleyl ether 2 parts by weight cetanol 3 parts by weight

Example 10 According to the following formulation,
The cosmetic of the present invention was prepared. That is, the components (a), (b) and (c) are each heated to 80 ° C., (b) is neutralized by adding (b) to (a) and emulsified by adding (c) while gradually stirring the mixture. Then, an emulsion, which is the cosmetic of the present invention, was obtained. Their stability (40 ° C, 30 days)
I found no problem at all. Further, the moist feeling and the sticky feeling were also ++. I Pemulen TR-1 0.2 parts by weight PGEMA (molecular weight 50,000) 1 part by weight Glycerin 3 parts by weight 1,3-butanediol 5 parts by weight Methylparaben 0.1 parts by weight Water 50 parts by weight 0.2 parts by weight of potassium hydroxide Water 30.5 parts by weight Hassqualane 5 parts by weight Glycerin monooleyl ether 2 parts by weight Cetanol 3 parts by weight

[0023]

According to the present invention, it is possible to provide a cosmetic composition which can be used safely even by a person with sensitive skin and which has an excellent feeling upon use.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Nobuhiro Ando 560, Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture F-term in the Totsuka Research Laboratory 4C083 AB032 AC022 AC072 AC122 AC172 AC482 AD091 AD092 AD391 AD392 CC05 DD31 EE06 EE10

Claims (6)

[Claims] 1. Containing 1) a sugar-bonded polymer in which a group containing a saccharide is covalently bonded to a polymer substrate and 2) a copolymer of acrylic acid and alkyl methacrylate (C10-30) and / or a salt thereof. Cosmetics characterized by doing. 2. The method according to claim 1, wherein the polymer substrate is selected from polystyrene, poly (-α-methylstyrene), polyamide, polyester, polypropylene, polycarbonate, urethane resin, fluorine resin, silicone and acrylic resin. The cosmetic according to claim 1. 3. The saccharide is glucose, arabinose, xylose, galactose, mannose, fructose,
One or more selected from glucosamine, sialic acid and / or a salt thereof, muramic acid and / or a salt thereof, glucuronic acid and / or a salt thereof, galacturonic acid and / or a salt thereof, and derivatives thereof The cosmetic according to claim 1 or 2, characterized in that: 4. The method according to claim 1, wherein the sugar-binding polymer is Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-
One or more selected from D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, and mannosyloxyethyl methacrylate The cosmetic according to any one of claims 1 to 3, wherein the cosmetic is a homopolymer or a copolymer containing two or more kinds as constituent monomers. 5. The method according to claim 5, wherein the sugar-binding polymer is Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-
One or more selected from D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, and mannosyloxyethyl methacrylate The cosmetic according to any one of claims 1 to 4, wherein the cosmetic is at least two kinds of homopolymers or copolymers. 6. It is for a person with sensitive skin,
The cosmetic according to any one of claims 1 to 5.