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ITUB20153920A1 - Dispositivo optofluidico. - Google Patents

Dispositivo optofluidico.

Info

Publication number
ITUB20153920A1
ITUB20153920A1 ITUB2015A003920A ITUB20153920A ITUB20153920A1 IT UB20153920 A1 ITUB20153920 A1 IT UB20153920A1 IT UB2015A003920 A ITUB2015A003920 A IT UB2015A003920A IT UB20153920 A ITUB20153920 A IT UB20153920A IT UB20153920 A1 ITUB20153920 A1 IT UB20153920A1
Authority
IT
Italy
Prior art keywords
optofluidic device
optofluidic
Prior art date
Application number
ITUB2015A003920A
Other languages
English (en)
Inventor
Andrea Bassi
Petra Paie'
Roberto Osellame
Francesca Bragheri
Original Assignee
Milano Politecnico
Consiglio Nazionale Ricerche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Milano Politecnico, Consiglio Nazionale Ricerche filed Critical Milano Politecnico
Priority to ITUB2015A003920A priority Critical patent/ITUB20153920A1/it
Priority to EP16777950.3A priority patent/EP3356796B1/en
Priority to PCT/EP2016/073007 priority patent/WO2017055290A1/en
Priority to US15/763,742 priority patent/US10520425B2/en
Publication of ITUB20153920A1 publication Critical patent/ITUB20153920A1/it

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/06—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of fluids in transparent cells
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/12—Fluid-filled or evacuated lenses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/144—Imaging characterised by its optical setup
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G01N2021/0307—Insert part in cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
ITUB2015A003920A 2015-09-28 2015-09-28 Dispositivo optofluidico. ITUB20153920A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITUB2015A003920A ITUB20153920A1 (it) 2015-09-28 2015-09-28 Dispositivo optofluidico.
EP16777950.3A EP3356796B1 (en) 2015-09-28 2016-09-27 Optofluidic device
PCT/EP2016/073007 WO2017055290A1 (en) 2015-09-28 2016-09-27 Optofluidic device
US15/763,742 US10520425B2 (en) 2015-09-28 2016-09-27 Optofluidic device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUB2015A003920A ITUB20153920A1 (it) 2015-09-28 2015-09-28 Dispositivo optofluidico.

Publications (1)

Publication Number Publication Date
ITUB20153920A1 true ITUB20153920A1 (it) 2017-03-28

Family

ID=54844012

Family Applications (1)

Application Number Title Priority Date Filing Date
ITUB2015A003920A ITUB20153920A1 (it) 2015-09-28 2015-09-28 Dispositivo optofluidico.

Country Status (4)

Country Link
US (1) US10520425B2 (it)
EP (1) EP3356796B1 (it)
IT (1) ITUB20153920A1 (it)
WO (1) WO2017055290A1 (it)

Families Citing this family (16)

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JP2017191228A (ja) * 2016-04-14 2017-10-19 オリンパス株式会社 ライトシート顕微鏡およびサンプル観察方法
US11092535B2 (en) * 2017-04-28 2021-08-17 Sony Corporation Imaging target analysis device, flow channel structure, imaging member, imaging method, and imaging target analysis system
DE102017122718A1 (de) * 2017-09-29 2019-04-04 Carl Zeiss Microscopy Gmbh Verfahren und Vorrichtung zur optischen Untersuchung einer Vielzahl mikroskopischer Proben
EP3729052B1 (en) * 2017-12-22 2022-03-16 Imec VZW A device for illuminating a particle, and a system and a method for particle imaging
JP7202904B2 (ja) * 2019-01-24 2023-01-12 リオン株式会社 粒子計数器
JP7260308B2 (ja) 2019-01-24 2023-04-18 リオン株式会社 流体中浮遊物質測定用フローセル及び粒子計数装置
JP2022520085A (ja) * 2019-02-12 2022-03-28 ユニヴァーシティ オブ ワシントン 顕微鏡用試料ホルダのための装置、システム及び方法
CN110618131B (zh) * 2019-09-12 2022-03-18 西北工业大学深圳研究院 一种大视场超分辨流体显微成像系统及其实现方法
DE102020201112A1 (de) 2020-01-30 2021-08-05 Robert Bosch Gesellschaft mit beschränkter Haftung Optische Auslesung von Prozessen innerhalb einer mikrofluidischen Vorrichtung
GB2595520A (en) * 2020-05-29 2021-12-01 Oxford Nanoimaging Ltd A diagnostic device and method
CN111929298B (zh) * 2020-07-20 2023-04-07 广东工业大学 一种显微镜下微流体通道y,z方向同时聚焦的观测方法
GB2600719B (en) * 2020-11-05 2023-10-11 Oxford Nanoimaging Ltd Fluorescence assay
CN117098980A (zh) 2021-02-04 2023-11-21 贝克顿·迪金森公司 集成光询问模块及其使用方法
CN113484320B (zh) * 2021-07-01 2024-08-02 西北大学 一种远场光学超薄片层成像系统及方法
CN114236801B (zh) * 2021-10-25 2024-01-05 北京京东方技术开发有限公司 光片生成装置及具有其的显微镜系统
DE102023101475A1 (de) * 2023-01-20 2024-07-25 Testo bioAnalytics GmbH Verfahren und Messkanal zur optischen Aufzeichnung von Mikropartikeln in einem Partikelstrom

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20120293797A1 (en) * 2009-12-17 2012-11-22 Universiteit Gent Methods and systems for optical characterisation

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US7574089B1 (en) * 2006-04-10 2009-08-11 Ge Homeland Protection, Inc. Optofluidic devices and methods of using the same
US7817698B2 (en) * 2006-08-11 2010-10-19 California Institute Of Technology Mechanically tunable elastomeric optofluidic distributed feedback dye lasers
US9357202B2 (en) * 2010-02-23 2016-05-31 California Institute Of Technology High resolution imaging devices with wide field and extended focus
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Publication number Priority date Publication date Assignee Title
US20120293797A1 (en) * 2009-12-17 2012-11-22 Universiteit Gent Methods and systems for optical characterisation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FRANCESCA BRAGHERI ET AL: "Optofluidic chip for single cell trapping and stretching fabricated by a femtosecond laser", JOURNAL OF BIOPHOTONICS, vol. 3, no. 4, April 2010 (2010-04-01), DE, pages 234 - 243, XP055278461, ISSN: 1864-063X, DOI: 10.1002/jbio.201000011 *
HENDRIK DESCHOUT ET AL: "On-chip light sheet illumination enables diagnostic size and concentration measurements of membrane vesicles in biofluids", NANOSCALE, vol. 6, no. 3, January 2014 (2014-01-01), United Kingdom, pages 1741 - 1747, XP055278454, ISSN: 2040-3364, DOI: 10.1039/C3NR04432G *
PAIÈ PETRA ET AL: "Adaptable acylindrical microlenses fabricated by femtosecond laser micromachining", OPTOMECHATRONIC MICRO/NANO DEVICES AND COMPONENTS III : 8 - 10 OCTOBER 2007, LAUSANNE, SWITZERLAND; [PROCEEDINGS OF SPIE , ISSN 0277-786X], SPIE, BELLINGHAM, WASH, vol. 9355, 9 March 2015 (2015-03-09), pages 935516 - 935516, XP060049892, ISBN: 978-1-62841-730-2, DOI: 10.1117/12.2079654 *

Also Published As

Publication number Publication date
US10520425B2 (en) 2019-12-31
EP3356796B1 (en) 2020-06-24
WO2017055290A1 (en) 2017-04-06
EP3356796A1 (en) 2018-08-08
US20180275045A1 (en) 2018-09-27

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