[go: up one dir, main page]

ITMI20031292A0 - Derivati biciclici nk-2 antagonisti selettivi - Google Patents

Derivati biciclici nk-2 antagonisti selettivi

Info

Publication number
ITMI20031292A0
ITMI20031292A0 IT2003MI001292A ITMI20031292A ITMI20031292A0 IT MI20031292 A0 ITMI20031292 A0 IT MI20031292A0 IT 2003MI001292 A IT2003MI001292 A IT 2003MI001292A IT MI20031292 A ITMI20031292 A IT MI20031292A IT MI20031292 A0 ITMI20031292 A0 IT MI20031292A0
Authority
IT
Italy
Prior art keywords
selective antagonists
bicycle derivatives
derivatives selective
bicycle
antagonists
Prior art date
Application number
IT2003MI001292A
Other languages
English (en)
Inventor
Stefania Gagliardi
Giuseppe Arnaldo Mari Giardina
Original Assignee
Nikem Research Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikem Research Srl filed Critical Nikem Research Srl
Priority to IT001292A priority Critical patent/ITMI20031292A1/it
Publication of ITMI20031292A0 publication Critical patent/ITMI20031292A0/it
Priority to PCT/EP2004/051210 priority patent/WO2005000845A2/en
Publication of ITMI20031292A1 publication Critical patent/ITMI20031292A1/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT001292A 2003-06-25 2003-06-25 Derivati biciclici nk-2 antagonisti selettivi. ITMI20031292A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT001292A ITMI20031292A1 (it) 2003-06-25 2003-06-25 Derivati biciclici nk-2 antagonisti selettivi.
PCT/EP2004/051210 WO2005000845A2 (en) 2003-06-25 2004-06-23 Bicyclic derivatives as nk-1 and nk-2 antagonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001292A ITMI20031292A1 (it) 2003-06-25 2003-06-25 Derivati biciclici nk-2 antagonisti selettivi.

Publications (2)

Publication Number Publication Date
ITMI20031292A0 true ITMI20031292A0 (it) 2003-06-25
ITMI20031292A1 ITMI20031292A1 (it) 2004-12-26

Family

ID=30131291

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001292A ITMI20031292A1 (it) 2003-06-25 2003-06-25 Derivati biciclici nk-2 antagonisti selettivi.

Country Status (2)

Country Link
IT (1) ITMI20031292A1 (it)
WO (1) WO2005000845A2 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2125750B1 (en) 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
PL2300461T3 (pl) 2008-05-01 2013-09-30 Vitae Pharmaceuticals Inc Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1
JP5379160B2 (ja) 2008-07-25 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2393807B1 (en) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 1,3−オキサジナン−2−オン構造に基づく11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤
JP5749263B2 (ja) 2009-07-01 2015-07-15 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための11−β−HSD1のインヒビターとしてのアザスピロヘキサノン
WO2012059416A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
WO2002083664A1 (en) * 2001-04-11 2002-10-24 Glaxosmithkline S.P.A. 3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

Also Published As

Publication number Publication date
WO2005000845A3 (en) 2005-04-07
ITMI20031292A1 (it) 2004-12-26
WO2005000845A2 (en) 2005-01-06

Similar Documents

Publication Publication Date Title
DK1594840T3 (da) Piperidin-benzensulfonamid-derivater
EP1632428A4 (en) COAXIAL MOTORCYCLE
NO20055186D0 (no) Fjellbolt
ATE352550T1 (de) Chinazolinderivate
DK1682493T3 (da) Amidoacetonitrilderivater
ITTO20040641A1 (it) Motociclo
DK1725553T3 (da) Tetrahydropyridoindolderivater
MA28816B1 (fr) Nouveaux derives de 4-benzylidene-piperidine
ATE540935T1 (de) Chinazolinderivate
ATE395345T1 (de) Imidazol-4-yl-ethynyl-pyridin-derivate
ATE383361T1 (de) Pyrrazolopyrimidinderivate
IS8180A (is) Nýjar besímídasólafleiður
DE602004010752D1 (de) Motorroller
ATE417830T1 (de) Sulfonylbenzimidazolderivate
DE602004013390D1 (de) Motorrad
ITTO20040166A1 (it) Motociclo
ITMI20031292A0 (it) Derivati biciclici nk-2 antagonisti selettivi
DK1682129T3 (da) N-thiazol-2-ylbenzamidderivater
DE602004018557D1 (de) Motorrad
ATE430142T1 (de) Phenylpiperazin-methanon-derivate
ATE449064T1 (de) Amidoacetonitrilderivate
IS8045A (is) Púrín-6-ón-afleiður
ATE404542T1 (de) 4-phenylpyrimidin-2-carbonitrilderivate
ATE365731T1 (de) 4-amino-5-cyanopyrimidinderivate
DE602006000765D1 (de) Fahrradbeleuchtung