ITMI920367A1 - Processo per la separazione degli stereoisomeri dell'acido folinico - Google Patents
Processo per la separazione degli stereoisomeri dell'acido folinicoInfo
- Publication number
- ITMI920367A1 ITMI920367A1 IT000367A ITMI920367A ITMI920367A1 IT MI920367 A1 ITMI920367 A1 IT MI920367A1 IT 000367 A IT000367 A IT 000367A IT MI920367 A ITMI920367 A IT MI920367A IT MI920367 A1 ITMI920367 A1 IT MI920367A1
- Authority
- IT
- Italy
- Prior art keywords
- folinic acid
- separation
- acid stereoisomers
- stereoisomers
- folinic
- Prior art date
Links
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical class C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 abstract 2
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 abstract 2
- 235000008191 folinic acid Nutrition 0.000 abstract 2
- 239000011672 folinic acid Substances 0.000 abstract 2
- 229960001691 leucovorin Drugs 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 1
- 229920000768 polyamine Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010956 selective crystallization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI920367A IT1254635B (it) | 1992-02-20 | 1992-02-20 | Processo per la separazione degli stereoisomeri dell'acido folinico |
| KR1019940702846A KR100256929B1 (ko) | 1992-02-20 | 1993-02-16 | 폴린산의 입체 이성질체 분리 방법 |
| PCT/EP1993/000361 WO1993017022A1 (en) | 1992-02-20 | 1993-02-16 | Process for separating stereoisomers of folinic acid |
| DE69319420T DE69319420T2 (de) | 1992-02-20 | 1993-02-16 | Verfahren zur trennung von stereoisomere von folinsäure |
| DE0626965T DE626965T1 (de) | 1992-02-20 | 1993-02-16 | Verfahren zur Trennung von Stereoisomere von Fölinsäure. |
| ES93903973T ES2065299T1 (es) | 1992-02-20 | 1993-02-16 | Procedimiento para la separacion de estereoisomeros del acido folinico. |
| AT93903973T ATE167864T1 (de) | 1992-02-20 | 1993-02-16 | Verfahren zur trennung von stereoisomere von folinsäure |
| JP51450793A JP3162073B2 (ja) | 1992-02-20 | 1993-02-16 | ホリニン酸の立体異性体を分離する方法 |
| EP93903973A EP0626965B1 (en) | 1992-02-20 | 1993-02-16 | Process for separating stereoisomers of folinic acid |
| GR940300096T GR940300096T1 (en) | 1992-02-20 | 1995-01-31 | Process for separating stereoisomers of folinic acid. |
| US08/456,767 US5599931A (en) | 1992-02-20 | 1995-06-01 | Process for separating stereoisomers of folinic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI920367A IT1254635B (it) | 1992-02-20 | 1992-02-20 | Processo per la separazione degli stereoisomeri dell'acido folinico |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI920367A0 ITMI920367A0 (it) | 1992-02-20 |
| ITMI920367A1 true ITMI920367A1 (it) | 1993-08-20 |
| IT1254635B IT1254635B (it) | 1995-09-28 |
Family
ID=11362053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI920367A IT1254635B (it) | 1992-02-20 | 1992-02-20 | Processo per la separazione degli stereoisomeri dell'acido folinico |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0626965B1 (it) |
| JP (1) | JP3162073B2 (it) |
| KR (1) | KR100256929B1 (it) |
| AT (1) | ATE167864T1 (it) |
| DE (2) | DE69319420T2 (it) |
| ES (1) | ES2065299T1 (it) |
| GR (1) | GR940300096T1 (it) |
| IT (1) | IT1254635B (it) |
| WO (1) | WO1993017022A1 (it) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5599931A (en) * | 1992-02-20 | 1997-02-04 | Bracco S.P.A. | Process for separating stereoisomers of folinic acid |
| IT1270185B (it) * | 1994-06-08 | 1997-04-29 | Bracco Spa | Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico |
| US5710271A (en) * | 1994-06-08 | 1998-01-20 | Dibra S.P.A. | Process for the preparation and separation of diastereomeric salts of folinic acid |
| CH696717A5 (de) * | 2004-02-20 | 2007-10-31 | Cerbios Pharma Sa | Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt |
| EP2502625A1 (en) * | 2011-03-21 | 2012-09-26 | GMT Fine Chemicals SA | Process for the preparation of crystalline levofolinic acid |
| EP3461826A1 (en) | 2017-09-29 | 2019-04-03 | Aprofol AG | Multifunctional folate salts |
| EP3646873A1 (en) | 2018-10-31 | 2020-05-06 | Aprofol AG | Folate salts |
| KR102339433B1 (ko) * | 2018-11-29 | 2021-12-15 | 주식회사 경보제약 | 고순도 팔로노세트론 중간체 제조 방법 |
| CN113666931B (zh) * | 2021-09-07 | 2023-11-03 | 浙江大为药业有限公司 | 一种高纯左亚叶酸钙的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2688018A (en) * | 1952-06-28 | 1954-08-31 | American Cyanamid Co | Method of preparing alkaline earth metal salts of 1-leucovorin |
| GB8621268D0 (en) * | 1986-09-03 | 1986-10-08 | Univ Strathclyde | Separation of substances |
| CH673459A5 (it) * | 1987-05-15 | 1990-03-15 | Eprova Ag | |
| DE3821875C1 (it) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
| JPH0265787A (ja) * | 1988-08-30 | 1990-03-06 | Kyowa Hakko Kogyo Co Ltd | Ｌ（‐）‐テトラヒドロ葉酸の製造法 |
| CH676981A5 (it) * | 1988-11-11 | 1991-03-28 | Eprova Ag | |
| ES2090075T3 (es) * | 1989-12-11 | 1996-10-16 | American Cyanamid Co | Procedimiento para la preparacion de diastereoisomeros opticamente puros de compuestos de tetrahidrofolato. |
| FR2659330B1 (fr) * | 1990-03-09 | 1994-02-11 | Sapec Sa | Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits. |
| CH680731A5 (it) * | 1990-04-12 | 1992-10-30 | Sapec Fine Chemicals | |
| CH681303A5 (it) * | 1991-01-16 | 1993-02-26 | Eprova Ag |
-
1992
- 1992-02-20 IT ITMI920367A patent/IT1254635B/it active
-
1993
- 1993-02-16 EP EP93903973A patent/EP0626965B1/en not_active Expired - Lifetime
- 1993-02-16 ES ES93903973T patent/ES2065299T1/es active Pending
- 1993-02-16 JP JP51450793A patent/JP3162073B2/ja not_active Expired - Lifetime
- 1993-02-16 KR KR1019940702846A patent/KR100256929B1/ko not_active Expired - Lifetime
- 1993-02-16 DE DE69319420T patent/DE69319420T2/de not_active Expired - Lifetime
- 1993-02-16 AT AT93903973T patent/ATE167864T1/de not_active IP Right Cessation
- 1993-02-16 WO PCT/EP1993/000361 patent/WO1993017022A1/en not_active Ceased
- 1993-02-16 DE DE0626965T patent/DE626965T1/de active Pending
-
1995
- 1995-01-31 GR GR940300096T patent/GR940300096T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07506813A (ja) | 1995-07-27 |
| DE69319420D1 (de) | 1998-08-06 |
| ATE167864T1 (de) | 1998-07-15 |
| JP3162073B2 (ja) | 2001-04-25 |
| ITMI920367A0 (it) | 1992-02-20 |
| DE69319420T2 (de) | 1998-11-05 |
| EP0626965B1 (en) | 1998-07-01 |
| KR100256929B1 (ko) | 2000-05-15 |
| ES2065299T1 (es) | 1995-02-16 |
| DE626965T1 (de) | 1995-07-06 |
| GR940300096T1 (en) | 1995-01-31 |
| KR950700300A (ko) | 1995-01-16 |
| WO1993017022A1 (en) | 1993-09-02 |
| IT1254635B (it) | 1995-09-28 |
| EP0626965A1 (en) | 1994-12-07 |
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